Prevalence and demographics of asthma - COPD overlap (ACO) among asthma and COPD patients in the pulmonary clinic of the University of the Philippines - Philippine General Hospital
Conclusion: The hospital has a statistically higher prevalence rate of ACO compared to worldwide data. COPD patients are more likely to have ACO than asthmatic patients. The ACO group has a median of 23 pack-years while the COPD group has a higher median of 46 pack-years. TB is more common in COPD. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Jaen, A. M., Fernandez, L., Tan, I. R., Wang, A., Villalobos, R. E., Cunada, M. Tags: Monitoring airway disease Source Type: research

Characterization of patients with pneumonia and chronic structural lung disease admitted to an ICU
Conclusion: We observed a high rate of agent identification. P. aeruginosa, A. baumannii and S. aureus were the most common. In patients infected with P. aeruginosa, mortality was higher in the COPD/E group. Mortality was significantly lower in the presence of initial antibiotic susceptibility. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Goncalves, G., Leitao, M. I., Linhares, L., Baptista, J. P., Martins, P. Tags: Acute critical care Source Type: research

Postoperative morbidity and mortality after pneumonectomy (PE) in pulmonary tuberculosis (TB) patients: a 5-year experience
Conclusions: The overall 90-day mortality after PE in TB patients was 2.4%. The postoperative TMM were connected with age, comorbid COPD, low functional level, blood flow in the removing lung. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Kiryukhina, L., Serezvin, I., Kudriashov, G., Denisova, N., Nefedova, N., Kovaleva, S., Savchenko, E., Avetisyan, A., Sokolovich, E., Yablonskii, P. Tags: Thoracic surgery Source Type: research

Single-stage bilateral VATS lungs resection from the unilateral access in patients with pulmonary tuberculosis
Purpose of the Study: To compare the effectiveness of single-stage bilateral pulmonary resection (SBPR) from unilateral intercostal-mediastinal access with video-assisted thoracoscopy (VATS) and consecutive bilateral pulmonary resection (CBPR) in treatment of patients with destructive pulmonary tuberculosis (TB).Material and Methods: An open, randomized, controlled, prospective clinical trial of 189 patients with bilateral destructive TB was conducted. In the 1st group (n=91), the SBPR with the VATS was performed from unilateral intercostal-mediastinal access, in the 2ndgroup (n=98), the CBPR was performed.Despite specific...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Krasnov, D., Karnauhov, V., Felker, I. Tags: Thoracic surgery Source Type: research

Postoperative risks in septuagenarians undergoing VATS lobectomy
Conclusion: Advanced age is not an independent risk factor for VATS anatomic lung resection. Septuagenarians can undergo VATS lobectomy with acceptable postoperative risk. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Maslak, O., Zinchenko, E., Kovalenko, A., Pischik, V., Obornev, A. Tags: Thoracic surgery Source Type: research

Recovery process in lung tissue patients with XDR tuberculosis after preoperative intravenous laser blood irradiation
Conclusion: The use of VLBI in preoperative preparation promotes healing processes and leads to effective surgical treatment. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Aliev, V., Sadovnikova, S., Krasnikova, E., Lepekha, L., Bagirov, M. Tags: Thoracic surgery Source Type: research

Pulmonary non-tuberculous mycobacterial infection: 889 cases
Conclusions: We are making a decision to treat NTM in a low proportion of patients with NTM in culture. The success rates of NTM treatment are low. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Babalık, A., Kuyucu, T., Kutluhan, F., Isık, H. G., Koc, E. N., Dönmez, G. E., Ordu, E. N., Balıkcı, A., Köksalan, O. K. Tags: Respiratory infections Source Type: research

Tobacco smoking as a risk factor of active tuberculosis in HIV-infected patients
Background: Despite the measures taken, tuberculosis (TB) is still a leading cause of mortality among persons living with HIV in Russian Federation. At the same time, it is known that tobacco smoking among HIV patients is more common than in the general population.Aim of the study is to investigate the effect of smoking on the risk of active tuberculosis in patients with HIV infection.Methods: In a case-control study we investigated 171 patients: 85 people in the HIV group, 86 people in the HIV/tuberculosis group. The tobacco dependence was diagnosed according to the criteria of the WHO. The smoking index calculated as the...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Kulabukhova, E., Zimina, V. N., Kravtchenko, A. V., Degtyareva, S. Y., Beloborodova, E. N., Peregudova, A. B. Tags: Tuberculosis Source Type: research

Characteristics of drug susceptibility testing for bedaquline and clofazimine of 178 drug-resistant Mycobacterium tuberculosis isolates in Japan
Conclusion: Our data suggested that DST for BDQ and CFZ might be necessary for MDR/XDR-TB before the treatment. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Takaki, A., Aono, A., Chikamatsu, K., Igarashi, Y., Shimomura, Y., Murase, Y., Yoshida, H., Tamura, Y., Nagai, T., Morishige, Y., Yamada, H., Mitarai, S. Tags: Tuberculosis Source Type: research

Bedaquiline containing regimens for the treatment of multi- and extensively drug-resistant tuberculosis at the programmatic level in Belarus. Prospective cohort study
Conclusions: The results of Belarus countrywide prospective cohort study of Bdq containing regimens used to treat M/XDR-TB showed satisfactory safety profile and good final treatment outcomes even in the cohort with a significant proportion of MDR-TB with advanced drug resistance profile (85% - XDR-TB and pre-XDR-TB). (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Skrahina, A., Hurevich, H., Setkina, S., Grankov, V., Solodovnikova, V., Viatushka, D., Kralko, V., Klimuk, D., Dara, M. Tags: Tuberculosis Source Type: research

Drug resistance-conferring mutations in Mycobacterium-tuberculosis isolated from retreated patients in Hanoi, Vietnam
Conclusions: In Hanoi city, drug resistance-conferring mutations are prevailing differently depending on MTB lineages and treatment history. Confirmation of sterilizing cure is important for better TB control. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Thi Le Hang, N., Hijikata, M., Maeda, S., Huu Thuong, P., Van Huan, H., Phuong Hoang, N., Matsushita, I., Keicho, N. Tags: Tuberculosis Source Type: research

Results of traditional and new regimens of MDR/XDR TB treatment: cohort analysis
Conclusion: The treatment regimen, based on the new approaches to their elaboration, are preferable in all groups of MDR/XDR TB patients. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Borisov, S. E., Filippov, A., Danilova, I., Kosenkov, S. Tags: Tuberculosis Source Type: research

Comorbidity clusters associated with length of hospital stay in patients with tuberculosis
Introduction: Tuberculosis (TB) is a global public health threat with significant burden to society and healthcare system. Outpatient treatment and shorter hospital stays may reduce costs. TB-associated length of hospital stay (LOS) is heterogeneous and it is of interest to better understand risk factors associated with longer LOS. The aim of this study was to investigate the relationship between comorbidities and LOS in patients hospitalized for TB.Methods: A Swiss-wide hospitalization database provided by the Swiss Federal Office for Statistics was used. Month and year of admission, gender, age, LOS and in-hospital morta...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Baty, F., Schoch, O., Tonko, S., Brutsche, M. Tags: Tuberculosis Source Type: research

High-dose rifampicin in tuberculosis: experiences from a Dutch tuberculosis centre
Conclusion: High-dose R, used in specific groups of patients in our clinical setting, is safe and well-tolerated for the whole treatment duration. Measurement of drug exposures could be used as a tool/guide to increase R dosage if a reduced medication absorption or a poor treatment outcome is suspected. Pending the results from clinical trials, we suggest to administer high-dose R to patients with severe manifestations of TB or low R exposure to improve treatment outcome. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Seijger, C., Hoefsloot, W., Bergsma, I., Van Ingen, J., Kuijpers, S., Te Brake, L., Van Crevel, R., Aarnoutse, R., Boeree, M., Magis-Escurra, C. Tags: Tuberculosis Source Type: research

Prevention of drug-induced liver injury in patients with pulmonary tuberculosis and chronic hepatitis C
Conclusion: complex of essential phospholipids and glycyrrhizin is effective for preventing of liver damage and providing of uniterrupted ATT among TB patients with CHC. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Ivanova, D., Borisov, S., Kudlay, D., Nikolenko, N., Slogotskaya, L., Garmash, Y. Tags: Clinical Problems Source Type: research

Clinical manifestation of small fiber neuropathy in patients with sarcoidosis and tuberculosis
Introduction: Patients with sarcoidosis (SC) and tuberculosis (TB) can develop a small fiber neuropathy (SFN), that is worsening the prognosis.Aim: To investigate the clinical manifestation of SFN in patients with SC and TB.Materials and Methods: In 2018-19, patients with histologically verified pulmonary SC (17 men, 5 women, aged 33.4±8.5 years), 16 patients with pulmonary TB in the pre-treatment period (9 men, 10 women, aged 36.6±9.3 years) and 73 healthy subjects (HS, 43 men, 30 women, aged 53,5±13,92 years) were included. A complete neurological investigation was performed. The questionnaire "...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Basantsova, N., Zinchenko, Y., Shapkina, V., Dori, A., Starshinova, A., Yablonskiy, P. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

The role of salivary gland biopsy in the diagnosis of sarcoidosis
Conclusion: In our study, salivary gland biopsy was diagnostic in half of the cases, and in 13.8% of the cases was diagnosed without any other invasive procedure. Therefore, it can be used as a priority biopsy method in patients with clinical and radiological suspicion of sarcoidosis. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Okumus, G., Bingol, Z., Sarisoy, M., Cagatay, T., Kiyan, E., Kilicaslan, Z. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Closure of bronchopleural fistula with bronchoscopic placement of ventricular septal defect occluders
Conclusions: Bronchoscopic placement of VSD occluders for BPF closure is safe and effective. The VSD occluders could be placed either in the fistula or in the bronchus corresponding to the fistula. Compared with surgical operation, it is less expensive, less invasive and easier to perform, and therefore is promising in the management of BPF. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Jiang, J., Guo, S., Li, Y., Liu, X., Jin, X., Xiao, Y., Xiao, M. Tags: Interventional pulmonology Source Type: research

Comparison between the diagnostic yield of tissue Xpert MTB/Rif assay and culture in pleural tuberculosis patients
Conclusion: Usually multiple tests are required to diagnose pleural tuberculosis. This increases the cost per patient and often there is a delay in diagnosis. Sensitivity and specificity of Xpert MTB/Rif assay scores high, hence escalating speed of diagnosis and imparts significant impact on patients’ outcome as it also gives status of drug resistance early. Xpert MTB/Rif assay is a potential game changer in diagnosing pleural tuberculosis. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Akhter, N., Khan, K., Chawla, D., Rizvi, N. Tags: Interventional pulmonology Source Type: research

Level of expertise in TB diagnosis among general practitioners
Conclusions: There is a need for systematic training in modern approaches to TB diagnosis as part of the curriculum of the Medical universities and advanced training courses in phthisiology. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Jakimova, M. A., Punga, V., Komissarova, O. Tags: Medical education, web and internet Source Type: research

Clinico-pathological patterns of the thoracic endometriosis
Conclusion: Our data allow to determine following features of the TE: the predominantly right-side localization, the young age of the patients, the cyclic recurrence of the hemoptysis and pain in the chest, the recurrent right-side pneumothorax, the correlation of the onset and/or regression of the radiological symptoms with the beginning and/or end of the menstrual cycle, infertility, pelvic pain, algomenorrhea, and surgeries on the pelvic organs in the anamnesis. In most of our observations, the endometriosis affected the diaphragm and was accompanied by the pneumothorax.Thus, the clinical and morphological hypodiagnosti...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Dvorakovskaya, I. V., Ariel, B. M., Novikova, L. N., Yablonskiy, P. K. Tags: Rare ILD/DPLD Source Type: research

Monocyte/neutrophil phagocytic activity ratio in differentiating tuberculosis from sarcoidosis
Clinical and pathological similarities between sarcoidosis (SA) and tuberculosis (TB) may cause a dangerous misdiagnosis. Therefore, there are searches for new biomarkers discriminating SA from TB. We revealed that genetically different SA or TB patients induce dissimilar immune responses to the same mycobacterial heat shock proteins, which are implicated in forming of immune complexes (CIs). The complexemia in both diseases may be a result of altered abilities of monocytes and/or neutrophils to phagocytosis/clearance CIs with following persistent antigenemia and granuloma formation. Therefore, we evaluated the phagocytic ...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Dubaniewicz, A., Rekawiecki, B., Piprek, M., Skotarczak, M., Dubaniewicz-Wybieralska, M. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Broncho-obstructive syndrome in patients with granulomatous pulmonary diseases
Conclusion: Bronchial obstruction was revealed in almost 1/3 of the patients with granulomatous pulmonary diseases. It is revealed more often in patients with hypersensitive pneumonitis (up to 59.6%). It needs treatment correction of bronchial obstructive syndrome. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Kuklina, G., Shmelev, E., Romanov, V. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Diagnosis of initial mild airway obstruction in the patients with pulmonary tuberculosis by the forced oscillation technique
Conclusion: Applying of FOT within the study of lung function can increase by 20% detection of airway obstruction at the initial stage of its development (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Zhukova, E. M., Vokhminova, L. Tags: Respiratory function technologists/scient. Source Type: research

Predicted versus observed respiratory parameters after lung resection in different postoperative periods in pulmonary tuberculosis patients
Conclusions: The applied formulae can be used in PT patients for predicting the respiratory parameters values in one month after SE and LE. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Denisova, N., Kiryukhina, L., Nefedova, N., Kudriashov, G., Sokolovich, E., Yablonskii, P. Tags: Thoracic surgery Source Type: research

Surgical management of pulmonary aspergillome: about 84 cases
Conclusion: Despite the advent of new medical treatments, surgery is still a standard in the management of pulmonary aspergilloma. Postoperative outcomes are highly influenced by the patient’s status and the complexity of the surgery. Intraoperative difficulties have to be kept in mind during management and the patient should be well prepared before surgery. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Hadj Dahmane, M., Zairi, S., Attia, M., Abdenadher, M., Zribi, H., Bouassida, I., Dridi, A., Ayadi, A., Brahem, A., Mestiri, T., Ben Miled, K., Mezni, F., Mrghli, A. Tags: Thoracic surgery Source Type: research

Analysis of early postoperative complications in patients underwent pneumonectomy for unilateral destructive pulmonary tuberculosis
Introduction: Often pneumonectomy remains the last chance to cure a patient with destructive pulmonary TB. The frequency of postoperative complications remains quite high.Objectives: Assess the frequency and structure of postoperative complications, identify the factors affecting them.Methods: Retrospective study. 69 patients, who had pneumonectomy for unilateral destructive pulmonary TB, years 2015 to 2017.Results: At the time of surgery sputum smear were positive in 46 (66,7%) patients, 23 (33,3%) were abacilated. The drug sensitivity of MTB was present in 16 (23,1%) patients. MDR - in 16 (23,2%), XDR - in 37 (53,6%). Si...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Serezvin, I., Vasilev, I., Avetisyan, A., Yablonskii, P. Tags: Thoracic surgery Source Type: research

Diagnostic of pleural effusion in HIV-positive patients
Conclusion: it is possible to consider thoracoscopy with biopsy as the only reliable method for diagnosing tuberculous pleurisy. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Sinitsyn, M., Abu Arqoub, T., Barsky, B., Plotkin, D., Reshetnikov, M. Tags: Thoracic surgery Source Type: research

Outpatient management of persistent air leak
Conclusions: The HV’s use not only is effective, but also generates an economic benefit and give autonomy to the patients. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Castillo Acosta, S., Castillo Acosta, J. C., Freixinet Gilart, J. L. Tags: Thoracic surgery Source Type: research

Extrapleural silicon plombage - a new opportunity of surgery for drug-resustant widespread pulmonary tuberculosis
Conclusions: Extrapleural silicon plombage expands the possibilities of surgery for patients with widespread distructive MDR anb XDR TB, who previously were considered inoperable. Moreover, ESP sussesful contributes to the maximum preservation of respiratory reserves and permits to avoid cosmetic demage. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Krasnikova, E., Popova, L., Aliev, V., Tarasov, R., Sadovnikova, S., Bagirov, M. Tags: Thoracic surgery Source Type: research

Lane Hamilton Syndrome without gastrointestinal symptoms
Discussion: Lane-Hamilton syndrome is very rare and it should be kept in mind in patients with pulmonary hemorrhage even without gastrointestinal symptoms. We gave gluten free diet and steroid to our patient because of active hemoptysis and respiratory symptoms and he was improved with the treatment. Although steroid treatment is controversial in the literature, it should be used in patients with active respiratory symptoms. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Sismanlar Eyuboglu, T., Sahin, G., Eroglu, N., Fettah, A., Akca Caglar, A., Yucel, H., Senel, S. Tags: Paediatric bronchology Source Type: research

Reversible Color Blindness due to Ethambutol in a Pediatric Patient with Pulmonary Tuberculosis
Discussion: Although it was reported that optic toxicity of ethambutol is very rare in patients who had lower dose of ethambutol treatment, it should be kept in mind in patient who received ethambutol treatment. Regular ophtalmological examination and questionning the patients in terms of ophtalmological complaints in every visit during tuberculosis treatment is very important for early detection of ophtalmological side effects of ethambutol. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Sismanlar Eyuboglu, T., Yasar Durmus, S., Sahin Karamert, S., Kaman, A., Teke, T., Oz, F. N., Tanır, G. Tags: Paediatric bronchology Source Type: research

Comparison of efficacy and safety of fixed-dose combination regimen versus separate drugs for treatment of tuberculosis
Conclusion: The reviewed studies showed that four-drug fixed-dose combination therapy provides greater patient comfort by reducing the number of pills as well as simplifying pharmaceutical management. However, the composition and dosage recommendations for fixed-dose combination formulations differ from those for separate formulations. Thus, questions about the effectiveness and side effects of combination formulations remain. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Boussoffara, L., Ammar, M., Boudawara, N., Bouchareb, S., Touil, I., Msakni, A., Knani, J. Tags: Paediatric bronchology Source Type: research

Clinical, microbiological profile and outcome of empyema thoracis in children: A retrospective study from a developing country
Conclusion: Empyema can be the initial manifestation of tuberculosis in children from the high endemic country. The duration of hospital stay was significantly prolonged in girl child, from rural area, emergency presentation, PICU admission, chest tube insertion and with BPF. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Kumar, P., Thakur, C., Singh, S., Goyal, J. Tags: Paediatric respiratory infection and immun. Source Type: research

Immunologic tests in diagnosis of tuberculosis infection in children of different age
Introduction: Early diagnosis of TB infection in children is complicated due to poor clinical signs, minor X-ray abnormalities, and absence of bacterial excression. Potential of Mantuox 2 TE test in population with common BCG vaccination is limited due to its low diagnostic specificity. Implementation of new immunologic tests allows improvement of early diagnosis of tuberculosis in children.Objective of the study: to compare revealing of latent tuberculosis infection (LTBI) and active tuberculosis in children with and without use of new immunologic tests (Diaskintest, T-SPOT).Material and Methods: We analized results of ex...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Starshinova, A., Dovgaliuk, I., Ovchinnikova, U., Starshinova, A., Yablonskiy, P. Tags: Paediatric respiratory infection and immun. Source Type: research

Vitamin D and LL-37 Levels In Childhood Tuberculosis Disease and Latent Tuberculosis Infection
Conclusions: Our study showed that vitamin D levels were significantly lower in patients with Tb disease; this is significantly more evident in the group where Tb was proven microbiologically. However the pathogenesis was not supported by LL-37 levels. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Yalcın, E., Emiralioglu, N., Tugcu, G., Eryılmaz, S., Hızal, M., Mete Yesil, A., Gönc, N., Dogru, D., Özcelik, U., Kiper, N. Tags: Paediatric respiratory infection and immun. Source Type: research

Significance of low cost pulmonary rehabilitation programme in post-pulmonary tubercular sequelae in patients of low socio-economic marginalized communities in India:Microbiological cure is the beginning and not the end of their illness
Conclusion: Our study shows that there is significant physical and psychological impairment in PTS . Pulmonary rehabilitation may provide better quality of life by using local resources and little investment. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Saini, S., Sudan, D., Jain, A. Tags: Rehabilitation and chronic care Source Type: research

Incentive spirometry and pursed lips breathing on breathlessness symptom, lung function, and quality of life in sequelae pulmonary tuberculosis
Conclusion: Incentive spirometry is improving IC and QoL better than pursed lips breathing even not statistically different. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Aphridasari, J., Sondakh, E. W., Setijadi, A. R., Sutanto, Y. S. Tags: Rehabilitation and chronic care Source Type: research

Characterisation of children hospitalised with pneumonia in central Vietnam: A prospective study
Background: Pneumonia is the most common reason for paediatric hospital admission in Vietnam. Potential value of using WHO case management approach in Vietnam has not been documented.Aims and Objectives: Characterise disease profile and assess risk factors for an adverse outcome of children admitted with ‘pneumonia’.Methods: Prospective descriptive study of all children under 5 admitted with ‘pneumonia’ (per clinician assessment) to Da Nang Hospital for Women and Children. Disease profile was classified using WHO pneumonia criteria, with tachypnea or chest indrawing as defining clinical signs. Adver...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Nguyen Thi Kim, P., Tran, H., Fitzgerald, D., Tran, T., Graham, S., Marais, B. Tags: Paediatric respiratory epidemiology Source Type: research

Transbronchial forcep and cryobiopsy of peripheral cavitary lung lesion under R-EBUS guidance in tuberculous endemic setting
Conclusion: Significant amount of PCLL were malignant in nature with low AFB smear positive rate. R-EBUS guided transbronchial biopsy has high diagnostic yield for PCLL with good safety profile. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Kho, S. S., Chai, C. S., Tee, T. T., Chan, S. K., Tie, S. T. Tags: Interventional pulmonology Source Type: research

EBUS TBNA in the rapid microbiological diagnosis of drug resistant tuberculous mediastinal lymphadenopathy
Conclusion: Xpert MTB/RIF assay carried out on the EBUS-TBNA specimens provide a rapid diagnosis in most patients with TB. However, all EBUS-TBNA specimens should be sent for both Xpert MTB/RIF testing as well as culture-based DST, which not only detects resistance to drugs other than rifampicin, but also detects rifampicin resistance that may be missed by Xpert MTB/RIF testing. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Chhajed, P. N., Vaidya, P. J., Mandovra, N. P., Chavhan, V. B., Lele, T. T., Nair, R., Leuppi, J. D., Saha, A. Tags: Interventional pulmonology Source Type: research

Evaluation of IP-10 in blood serum for TB diagnosis in patients with late-stage HIV infection
Conclusions: 1) The level of chemokine IP-10 does not depend on TB dissemination (disseminated forms of TB: 2021.39 ± 465.9 pg/ml (CI±913.16 pg/ml), limited forms: 2616.25 ± 466.7 pg/ml (CI±914.7 pg/ml), p>0.05); 2) The level of IP-10 depends on sputum positivity (sputum positive patients: 2713.02 ± 498.15 pg/ml (CI±967.3 pg/ml), and sputum negative patients: 988.01 ± 319.28 pg/ml (CI±625.8 pg/ml), P=0.012103). (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Dudchenko, A., Karpina, N., Averbakh, M., Ergesho, A. Tags: Tuberculosis Source Type: research

Comparison of the change in QuantiFERON-TB Gold Plus and QuantiFERON-TB Gold In-Tube results after preventive therapy for latent tuberculosis infection
Conclusions: The change in the IFN- level before and after LTBI treatment measured using QFT-Plus assay showed a similar trend to that of QFT-GIT assay. Considering that QFT-GIT assay is not a useful biomarker of LTBI treatment response, QFT-Plus may also not be useful for this purpose. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Jo, K.-W., Kim, O.-H., Park, S., Jo, Y.-H., Kim, M.-N., Sung, H., Shim, T. S. Tags: Tuberculosis Source Type: research

The meaning of a high monocyte to lymphocyte ratio in tuberculosis
Conclusions: The ML ratio is an indicator of S+PTB, but does not reflect disease severity or prognosis. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Buttle, T., Bothamley, G. Tags: Tuberculosis Source Type: research

Utility of MPT64 antigen detection test for diagnosis of HIV coinfected extrapulmonary tuberculosis in Tanzania
Conclusions: The MPT64 test is better than routine tests for diagnosing EPTB. It performs well irrespective of HIV status. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Gronningen, E., Sviland, L., Ngadaya, E., Nanyaro, M., Muller, W., Torres, L., Mfinanga, S., Mustafa, T. Tags: Tuberculosis Source Type: research

Combined evaluation of TBAg/M, IL22 and IL17 to predict LTBI progression
Tuberculosis (TB) remains a major health issue worldwide, with 10 million new cases and 1.6 million deaths in 2017. According to WHO, about one third of the world’s population is infected with M. tuberculosis (MTV). The widely used interferon gamma-release assays (QFT,T-SPOT) do not differentiate between latent MTB infection (LTBI) and its active phase. Recently, multicytokine analysis, and TBAg/M ratio from T-SPOT were proposed to distinguish LTBI from active TB (ATB).Aim: To compare QFT TBAg/M, as well as IL17 and IL22 MTB-specific profiles in ATB and LTBI subjects.Materials and methods: Peripheral blood samples fr...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Todorova, Y., Emilova, R., Milanov, V., Bachiyska, E., Atanasova, Y., Varleva, T., Eneva, L., Nikolova, M. Tags: Tuberculosis Source Type: research

New guidelines for screening for tuberculosis and latent tuberculosis infection pre-immunosuppressive therapy in the Netherlands: a targeted and stratified approach
A considerable proportion of the world’s population is latently infected with Mycobacterium tuberculosis (MTB) complex (LTBI) but in low-incidence counties as the Netherlands (4.6 TB cases/100.000 /year) LTBI prevalence is predominantly found among the elder population and foreign-born residents. In resource-rich countries implementation of immunosuppressive therapies with "biologicals", show a rapid rise with increased risk of LTBI progressing to, often serious forms of, active TB. Worldwide it is advised to screen all candidates for of immunosuppressive therapies for TB with a chest X-ray and LTBI with at...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: van der Valk, p., Van Crevel, R., Jde Steenwinkel, J., Bakker, M., Vonkeman, H., Van Hest, R. Tags: Tuberculosis Source Type: research

Outcomes of new entrant TB screening in Bolton, UK
Conclusions: The majority of new entrants invited to our clinic attended (66%). A significant number (26%) of these patients are diagnosed with LTBI. The incidence of LBTI is greater in the patients referred by asylum team, noting that they were pre-screened with the Mantoux test. We aim to continue to monitor our new entrant screening service and clinic outcomes, and to compare with services in neighbouring regions.Reference:1. Collaborative TB Strategy for England 2015–2020: PHE2015, January (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Katzenberg, G., Ahmed, R. Tags: Tuberculosis Source Type: research

Prospective validation of a proposed severity-of-illness score in patients with tuberculosis requiring intensive care unit admission
We previously retrospectively validated a 6-point severity-of-illness score aimed at identifying patients at risk of dying of TB in ICU. The parameters used were septic shock, HIV with a CD4
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Koegelenberg, C. F. N., Lalla, U., Taljaard, J. J., Allwood, B. W., Irusen, E. M. Tags: Tuberculosis Source Type: research

Sensitivity and specificity of loop-mediated isothermal amplification assay for diagnosis of extra-pulmonary tuberculosis: A cross-sectional study
Conclusion: LAMP has good sensitivity & specificity in EPTB specimens. Further studies are required to establish utility of LAMP as a diagnostic tool for EPTB. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Singh, P., Kanade, S., Nataraj, G. Tags: Tuberculosis Source Type: research