In vitro  production of ergothioneine isotopologues.
We describe a general protocol for the production of ergothioneine isotopologues with programmable 2H, 15N 13C, 34S and 33S isotope labelling patterns. This enzyme-based approach makes efficient use of commercial isotope reagents and is also directly applicable for the synthesis of radio-isotopologues. PMID: 32996678 [PubMed - as supplied by publisher] (Source: Angewandte Chemie)
Source: Angewandte Chemie - September 29, 2020 Category: Chemistry Authors: Beliaeva MA, Burn R, Lim D, Seebeck FP Tags: Angew Chem Int Ed Engl Source Type: research

Three new p-coumaroylated sesquiterpenoids from Pilea cavaleriei.
Abstract Four p-coumaroylated sesquiterpenoids (1-4), including three new ones (1, 2, and 4), were isolated from the whole plants of Pilea cavaleriei. Their structures were established on the basis of comprehensive spectroscopic analysis and comparison with data reported in the literature. Compounds 1-4 were evaluated for their antimycobacterial activities, and 2 and 4 were active against Mycobacterium tuberculosis H37Rv with the MIC values of 19.6 ± 0.19 and 17.4 ± 0.12 μg/mL, respectively.[Formula: see text]. PMID: 32993365 [PubMed - as supplied by publish...
Source: Natural Product Research - September 29, 2020 Category: Biochemistry Authors: Zhou Y, Ren HC, Zhang QY, Liang H, Tu PF Tags: Nat Prod Res Source Type: research

In-hospital mortality and its predictors in a cohort of SLE from Northern India.
CONCLUSION: Infections are the most common cause of in-hospital mortality in SLE and TB still accounts for 15% of deaths related to infection. Vasculitis, myositis, cardiovascular and gastrointestinal involvement emerged as novel predictors of mortality in our cohort. PMID: 32998621 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - September 29, 2020 Category: Rheumatology Authors: Pattanaik SS, Muhammed H, Chatterjee R, Naveen R, Lawrence A, Agarwal V, Misra DP, Gupta L, Misra R, Aggarwal A Tags: Lupus Source Type: research

Cavitary Pulmonary Tuberculosis with COVID-19 coinfection
Publication date: Available online 28 September 2020Source: IDCasesAuthor(s): Zohaib Yousaf, Adeel A. Khan, Haseeb A. Chaudhary, Kamran Mushtaq, Jabeed Parengal, Mohamad Aboukamar, Muhammad Umair Khan, Mouhand F.H. Mohamed (Source: IDCases)
Source: IDCases - September 29, 2020 Category: Infectious Diseases Source Type: research

Incidence of and Risk Factors for Tuberculosis among Cancer Patients in Endemic Area: A Regional Cohort Study.
This study aimed to investigate risk factors for TB among cancer patients in an area with endemic TB infections. METHODS: We used the Khon Kaen population-based cancer registry and two TB databases to conduct a retrospective cohort study of cancer patients. From 2001 to 2015, we identified 40,948 eligible cancer patients. Following until 2017, we identified cases of TB diagnosed after cancer diagnosis and analyzed primary cancer site, staging, treatment, and demographic factors. Adjusted incidence rate ratios (adj. IRR) were computed to identify risk factors among a sub-set of cancer types (n = 9,733) using Poisson reg...
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Takayasu Arteritis Masquerading as Resistant Hypertension and Tuberculosis.
Authors: Dilip KR, Adhiti K Abstract We here report a case of Takayasu arteritis who came to us with uncontrolled hypertension, arm claudication and a history of Pott's spine (treated). She was treated with steroids which led to significant improvement in the patient's clinical profile. PMID: 32978929 [PubMed - in process] (Source: Journal of the Association of Physicians of India)
Source: Journal of the Association of Physicians of India - September 29, 2020 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

Diagnostic accuracy of 3 urine lipoarabinomannan tuberculosis assays in HIV-negative outpatients
CONCLUSION Compared with AlereLAM, FujiLAM detected 5 times more patients with TB in HIV-negative participants, had a high positive predictive value, and has the potential to improve rapid diagnosis of TB at the point-of-care. EclLAM demonstrated that additional sensitivity gains are possible, which highlights LAM’s potential as a biomarker. Additional research is required to assess FujiLAM’s performance in prospective cohorts, its cost-effectiveness, and its impact in real-world clinical settings.FUNDING Global Health Innovative Technology Fund, the UK Department for International Development, the Dutch Minist...
Source: Journal of Clinical Investigation - September 29, 2020 Category: Biomedical Science Authors: Tobias Broger, Mark P. Nicol, George B. Sigal, Eduardo Gotuzzo, Alexandra J. Zimmer, Shireen Surtie, Tatiana Caceres-Nakiche, Anna Mantsoki, Elena Ivanova Reipold, Rita Székely, Michael Tsionsky, Judith van Heerden, Tatiana Plisova, Kinuyo Chikamatsu, To Source Type: research

Getting to the point in point-of-care diagnostics for tuberculosis
This study shows that FujiLAM has considerable potential to reshape the TB diagnostics landscape, making diagnosis and treatment in one office visit a reality for TB. (Source: Journal of Clinical Investigation)
Source: Journal of Clinical Investigation - September 29, 2020 Category: Biomedical Science Authors: Elisa H. Ignatius, Keira A. Cohen, William R. Bishai Source Type: research

Can natural language processing help differentiate inflammatory intestinal diseases in China? Models applying random forest and convolutional neural network approaches
Differentiating between ulcerative colitis (UC), Crohn ’s disease (CD) and intestinal tuberculosis (ITB) using endoscopy is challenging. We aimed to realize automatic differential diagnosis among these diseases... (Source: BMC Medical Informatics and Decision Making)
Source: BMC Medical Informatics and Decision Making - September 29, 2020 Category: Information Technology Authors: Yuanren Tong, Keming Lu, Yingyun Yang, Ji Li, Yucong Lin, Dong Wu, Aiming Yang, Yue Li, Sheng Yu and Jiaming Qian Tags: Research article Source Type: research

Hemophagocytic syndrome associated with Mycobacterium bovis in a patient with X-SCID: a case report
Mycobacterium bovis could infect patients with immunodeficiency or immunosuppressive conditions via Bacillus Calmette-Gu érin (BCG) vaccination. Tuberculosis-related hemophagocytic syndrome (HPS) is reported, but ... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - September 29, 2020 Category: Infectious Diseases Authors: Buyun Shi, Ming Chen, Zhi Xia, Shuna Xiao, Wen Tang, Chenguang Qin, Ying Cheng, Tao Huang, Chengjiao Huang, Yong Li and Hui Xu Tags: Case report Source Type: research

Epidemiological characterization of Mycobacterium caprae strains isolated from wildlife in the Bieszczady Mountains, on the border of Southeast Poland
The majority of animal tuberculosis (TB) cases reported in wildlife in Poland over the past 20 years have concerned the European bison inhabiting the Bieszczady Mountains in Southeast Poland: an area running a... (Source: BMC Veterinary Research)
Source: BMC Veterinary Research - September 29, 2020 Category: Veterinary Research Authors: Blanka Or łowska, Monika Krajewska-Wędzina, Ewa Augustynowicz-Kopeć, Monika Kozińska, Sylwia Brzezińska, Anna Zabost, Anna Didkowska, Mirosław Welz, Stanisław Kaczor, Piotr Żmuda and Krzysztof Anusz Tags: Research article Source Type: research

Mycobacterium tuberculosis-specific cytokine biomarkers to differentiate active TB and LTBI: A systematic review
It is estimated that one-quarter of the world's population is infected with Mycobacterium tuberculosis (MTB)1. Despite effective treatment being available for over 70 years, it continues to be the leading cause of death from a single infectious disease worldwide2. One of the main factors contributing to this toll is the limitations of current diagnostic tests. As a result, an estimated 3 million cases of tuberculosis (TB) each year are not diagnosed or notified3, 4. (Source: Journal of Infection)
Source: Journal of Infection - September 28, 2020 Category: Infectious Diseases Authors: Eva L. Sudbury, Vanessa Clifford, Nicole L. Messina, Rinn Song, Nigel Curtis Tags: Review Source Type: research

Emergence of Specific gyrA Mutations Associated High-Level Fluoroquinolone-Resistant Mycobacterium tuberculosis among Multidrug-Resistant Tuberculosis Cases in North India
Microbial Drug Resistance, Ahead of Print. (Source: Microbial Drug Resistance)
Source: Microbial Drug Resistance - September 28, 2020 Category: Microbiology Authors: Pravin Kumar Singh Urmila Singh Amita Jain Source Type: research

Depression and delayed tuberculosis treatment initiation among newly diagnosed patients in Botswana
. (Source: Global Public Health)
Source: Global Public Health - September 28, 2020 Category: International Medicine & Public Health Authors: Keneilwe Molebatsi Qiao Wang Mbatshi Dima Ari Ho-Foster Chawangwa Modongo Nicola Zetola Sanghyuk S. Shin Source Type: research

Andrographolide exerts anti-inflammatory effects in Mycobacterium tuberculosis-infected macrophages by regulating the Notch1/Akt/NF- κB axis.
Andrographolide exerts anti-inflammatory effects in Mycobacterium tuberculosis-infected macrophages by regulating the Notch1/Akt/NF-κB axis. J Leukoc Biol. 2020 Sep 29;: Authors: He W, Sun J, Zhang Q, Li Y, Fu Y, Zheng Y, Jiang X Abstract Tuberculosis is a serious public health problem aggravated by the slow progress in the development of new anti-tuberculosis drugs. The hyper-reactive TB patients have suffered from chronic inflammation which could cause deleterious effects on their bodies. Therefore, it is imperative to develop an adjunctive therapy based on inflammatory modulation du...
Source: Journal of Leukocyte Biology - September 28, 2020 Category: Hematology Authors: He W, Sun J, Zhang Q, Li Y, Fu Y, Zheng Y, Jiang X Tags: J Leukoc Biol Source Type: research

SLAMF1 signaling induces Mycobacterium tuberculosis uptake leading to endolysosomal maturation in human macrophages.
lli V Abstract Tuberculosis dates back to ancient times but it is not a problem of the past. Each year, millions of people die from tuberculosis. After inhalation of infectious droplet nuclei, Mycobacterium tuberculosis reaches the lungs where it can manipulate the immune system and survive within host macrophages, establishing a persistent infection. The signaling lymphocytic activation molecule family member 1 (SLAMF1) is a self-ligand receptor that can internalize gram-negative bacteria and regulate macrophages' phagosomal functions. In tuberculosis, SLAMF1 promotes Th1-protective responses. In this work, we st...
Source: Journal of Leukocyte Biology - September 28, 2020 Category: Hematology Authors: Barbero AM, Trotta A, Genoula M, Pino REHD, Estermann MA, Celano J, Fuentes F, García VE, Balboa L, Barrionuevo P, Pasquinelli V Tags: J Leukoc Biol Source Type: research

Sirtuin inhibits M. tuberculosis -induced apoptosis in macrophage through glycogen synthase kinase-3 β.
Sirtuin inhibits M. tuberculosis -induced apoptosis in macrophage through glycogen synthase kinase-3β. Arch Biochem Biophys. 2020 Sep 29;:108612 Authors: Yang H, Chen J, Chen Y, Jiang Y, Ge B, Hong L Abstract Apoptotic and inflammatory pathways play important roles in Mycobacterium tuberculosis-infected macrophages. Sirt1 is a member of the deacetylase family that is known to promote apoptosis resistance in mammalian cells and was recently reported to regulate mycobacterial immunopathogenesis via inflammatory responses. However, the apoptotic role of Sirt1 in the process of M. tuberculosis infect...
Source: Archives of Biochemistry and Biophysics - September 28, 2020 Category: Biochemistry Authors: Yang H, Chen J, Chen Y, Jiang Y, Ge B, Hong L Tags: Arch Biochem Biophys Source Type: research

Tuberculosis in Patients with Primary Myelofibrosis During Ruxolitinib Therapy: Case Series and Literature Review
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - September 28, 2020 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

Worsening CSF Parameters After the Start of Anti-tuberculosis Treatment Predicts Intracerebral Tuberculoma Development
(Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - September 27, 2020 Category: Infectious Diseases Authors: Yuying Lu, Zhongyang Hu, Fuyan Wang, Huan Yao, Haixia Zhu, Zhen Wang, Zhi Song, Ru Chen, Ding Liu Source Type: research

IJERPH, Vol. 17, Pages 7088: Tuberculosis and Other Airborne Microbes in Occupational Health and Safety
iacute;as Pilar Aparicio-Martínez Airborne pathogens and non-malignant infectious diseases such as tuberculosis are highly contagious and can have severe effects on healthcare workers. The symptoms of these diseases take time to manifest, which can prevent workers from noticing that they have been exposed until symptoms appear. The current paper sought to assess the occupational safety and preventative measures taken in laboratories in Spain, and to compare these measures with those reported by other studies worldwide. A cross-sectional study of workers (35–50 years old) was conducted using a web...
Source: International Journal of Environmental Research and Public Health - September 27, 2020 Category: Environmental Health Authors: Esther Vaquero- Álvarez Antonio Cubero-Atienza Pilar Ruiz-Mart ínez Manuel Vaquero-Abell án Mar ía Dolores Redel-Macías Pilar Aparicio-Mart ínez Tags: Article Source Type: research

Antigens of Mycobacterium tuberculosis Stimulate CXCR6+ Natural Killer Cells
Natural killer (NK) cells participate in immunity against several pathogens by exerting cytotoxic and cytokine-production activities. Some NK cell subsets also mediate recall responses that resemble memory of adaptive lymphocytes against antigenic and non-antigenic stimuli. The C-X-C motif chemokine receptor 6 (CXCR6) is crucial for the development and maintenance of memory-like responses in murine NK cells. In humans, several subsets of tissue-resident and circulating NK cells with different functional properties express CXCR6. However, the role of CXCR6+ NK cells in immunity against relevant human pathogens is unknown. H...
Source: Frontiers in Immunology - September 27, 2020 Category: Allergy & Immunology Source Type: research

A clinical decision tool for septic arthritis in children based on epidemiologic data of atraumatic swollen painful joints in South Africa
ConclusionsDespite insignificant differences in their clinical presentation compared with non-infectious arthidities, 15% of children were diagnosed with tissue-confirmed TB infection. Predictive values of clinical criteria are reduced in our population due to elevated levels of inflammatory markers in all patients. Synovial biopsy to rule out TB is recommended in all patients in a high-burden setting given clinical similarity to non-infectious aetiologies. (Source: International Orthopaedics)
Source: International Orthopaedics - September 27, 2020 Category: Orthopaedics Source Type: research

Distinct Risk Factors for Clinical and Bacteriologically Confirmed Tuberculosis among Child Household Contacts in a High-Burden Setting.
Abstract The identification and screening of children at high risk of tuberculosis is essential to the control and prevention of child tuberculosis (TB). BUTIMBA, an active case finding and household contact-tracing project implemented between 2013 and 2015 in Eswatini, evaluated 5,417 child household contacts of 1,568 index cases, of whom 82 (1.5%) were diagnosed with TB disease. We conducted univariate and multivariate clustered logistic regression analyses of risk factors for any TB diagnosis among child household contacts of TB cases. Children younger than 5 years and children with positive HIV status were mor...
Source: The American Journal of Tropical Medicine and Hygiene - September 27, 2020 Category: Tropical Medicine Authors: Sandoval M, Swamy P, Kay AW, Ustero P, Dube GS, Hlophe-Dlamini H, Mandalakas AM Tags: Am J Trop Med Hyg Source Type: research

Imaging in Tubercular Choroiditis: Current Concepts.
CONCLUSIONS: Fundus imaging plays a vital role in the diagnosis and management of patients with posterior uveitis due to tuberculosis. Fundus imaging may have a useful role in defining clinical endpoints for ocular tuberculosis in the future. PMID: 32976732 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 27, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Subretinal Hemorrhage Complicating Retinal Angiomatous Proliferation in Tubercular Retinal Vasculitis.
CONCLUSION: This case highlights that rare vascular alterations such as RAP can develop in subjects with ocular tuberculosis. PMID: 32976040 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 27, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

SFTPC genetic polymorphisms are associated with tuberculosis susceptibility and clinical phenotype in a Western Chinese Han population.
Authors: Zhao JW, Jiao L, Guo MM, Zheng L, Wang XB, Gao SH, Ying BW, Ming L Abstract Tuberculosis (TB) is one of the most common infectious diseases globally. The surfactant protein C (SFTPC), which is involved in innate immunity and surfactant function in the lung, may contribute toward the progression of TB. The aim of the present study was to preliminarily investigate the possible association of single nucleotide polymorphisms (SNPs) in the SFTPC gene with TB susceptibility and clinical phenotypes in a Western Chinese Han population. The improved multiplex ligation detection reaction method was used to genotype ...
Source: Experimental and Therapeutic Medicine - September 27, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Quantitative Proteomic Analysis of the Expression of SARS-CoV-2 Receptors in the Gut of Patients with Chronic Enterocolitis.
In conclusion, gut inflammation associated with chronic colitis does not mediate a further increase in the cellular entry of SARS-CoV-2. PMID: 32975064 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - September 27, 2020 Category: Universities & Medical Training Authors: Park J, Jeong D, Chung YW, Kim DH, Cheon JH, Ryu JH Tags: Yonsei Med J Source Type: research

A rare cutaneous tuberculosis form, erythema induratum of Bazin: 6 years' experience.
CONCLUSIONS: EIB's etiopathogenesis is unknown. In total, 75.0% of the patients receiving tuberculosis treatment and 87.5% of the patients without tuberculosis treatment recovered in our study. The role of tuberculous therapy in the management of EIB is controversial. The selection of appropriate treatment for EIB continues to be an area of debate, and further studies are needed. PMID: 32975298 [PubMed - in process] (Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica)
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - September 26, 2020 Category: Dermatology Tags: Acta Dermatovenerol Alp Pannonica Adriat Source Type: research

An evolving fungal infection: a case report of disseminated histoplasmosis
An 83-year-old Singaporean man presented to clinic for abdominal pain associated with loss of appetite and weight. He had a significant past medical history of hypertension, hyperlipidaemia, previously treated pulmonary tuberculosis, benign prostatic hyperplasia and peripheral vascular disease. His chronic medications included, aspirin, omeprazole, simvastatin and losartan. Otherwise, he did not have any fever, chills, vomiting, diarrhea, haematochezia, melena, change in bowel habits, cough, dyspnea, chest pain, headache, myalgia, joint pain, dizziness, odynophagia or dysphagia. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - September 26, 2020 Category: General Medicine Authors: Stephen Ching-Tung So Tags: Diagnostic Dilemma Source Type: research

TB47 and clofazimine form a highly synergistic sterilizing block in a second-line regimen for tuberculosis in mice
Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Wei Yu, Gift Chiwala, Yamin Gao, Zhiyong Liu, Sanjeep Sapkota, Zhili Lu, Lingmin Guo, Shahzad Akbar Khan, Nanshan Zhong, Tianyu Zhang (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - September 26, 2020 Category: Drugs & Pharmacology Source Type: research

In vitro and in vivo antimicrobial activities of a novel piperazine-containing benzothiazinones candidate TZY-5-84 against Mycobacterium tuberculosis
Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Shaochen Guo, Lei Fu, Bin Wang, Xi Chen, Jiaojie Zhao, Mingliang Liu, Yu Lu (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - September 26, 2020 Category: Drugs & Pharmacology Source Type: research

[Epidemiological profile of extensively drug-resistant tuberculosis in Peru, 2013-2015Perfil epidemiol ógico da tuberculose extremamente resistente no Peru, 2013-2015].
Conclusions: This study offers important details of the epidemiological profile of XDR-TB in Peru, where there has been an increase in cases of primary XDR-TB; that is, cases with no prior history of disease. Furthermore, this form of tuberculosis has spread to a greater number of departments in the country. PMID: 32973891 [PubMed] (Source: Pan American Journal of Public Health)
Source: Pan American Journal of Public Health - September 26, 2020 Category: International Medicine & Public Health Tags: Rev Panam Salud Publica Source Type: research

Optic Nerve Infiltration in Systemic Metastatic Retinal Lymphoma (SMRL): Multimodal Imaging and Challenges in Diagnosis.
CONCLUSION: Optic nerve infiltration in systemic metastatic retinal lymphoma may have initial occult signs but with profound visual loss. Ocular infections like CMV retinitis and tuberculosis may mask and delay the diagnosis in immunocompromised patients. PMID: 32967510 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 26, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

The seedbeds of Tuberculosis: is it time to target congregate settings and workplaces?
Countries where the incidence of Tuberculosis (TB) is low display a low transmission rate in the general population, and this rate has progressively declined in recent decades; however, TB epidemiology has shown a shift of the disease burden from the general population to specific populations at higher risk, such as vulnerable individuals and hard-to-reach groups. In low-incidence countries, preventive and therapeutic strategies must therefore be geared towards targeted interventions in these populations, with the priority being to promptly identify and treat latent tuberculosis infection (LTBI) rather than manage infectio...
Source: Journal of Preventive Medicine and Hygiene - September 26, 2020 Category: International Medicine & Public Health Authors: Montecucco Montecucco, Guglielmo Dini, Alborz Rahmani, Laura Sticchi, Paolo Durando Source Type: research

Comparative structural and mechanistic studies of 4-hydroxy-tetrahydrodipicolinate reductases from Mycobacterium tuberculosis and Vibrio vulnificus
Publication date: Available online 24 September 2020Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Swanandi Pote, Sangita Kachhap, Nicholas J. Mank, Leily Daneshian, Vincent Klapper, Sarah Pye, Amy K. Arnette, Linda S. Shimizu, Tomasz Borowski, Maksymilian Chruszcz (Source: Biochimica et Biophysica Acta (BBA) General Subjects)
Source: Biochimica et Biophysica Acta (BBA) General Subjects - September 25, 2020 Category: Biochemistry Source Type: research

Endobronchial Valve Placement for Pulmonary Tuberculosis-related Bronchocutaneous Fistula After Thoracoplasty
No abstract available (Source: Journal of Bronchology and Interventional Pulmonology)
Source: Journal of Bronchology and Interventional Pulmonology - September 25, 2020 Category: Respiratory Medicine Tags: Images in Interventional Pulmonology Source Type: research

Genomic analysis of Latin American-Mediterranean family of Mycobacterium tuberculosis clinical strains from Kazakhstan.
Abstract The human-adapted strains of the Mycobacterium tuberculosis complex (MTBC) comprise seven phylogenetic lineages originally associated with their geographical distribution. Here, we report the genomes of three drug-resistant clinical isolates of the Latin American-Mediterranean (LAM) family collected in Kazakhstan. We utilised whole-genome sequencing to study the distribution and drug resistance of these isolates. Phylogenetic analysis grouped the genomes described in this study with the sequences from Russia, Uzbekistan, and Kazakhstan belonging to the LAM family. One isolate has acquired extensive drug r...
Source: Memorias do Instituto Oswaldo Cruz - September 25, 2020 Category: Infectious Diseases Authors: Tarlykov P, Atavliyeva S, Alenova A, Ramankulov Y Tags: Mem Inst Oswaldo Cruz Source Type: research

Multidrug-resistant tuberculosis in children and adolescents: current strategies for prevention and treatment.
Authors: Seddon JA, Johnson S, Palmer M, van der Zalm MM, Lopez-Varela E, Hughes J, Schaaf HS Abstract Introduction An estimated 30,000 children develop multidrug-resistant (MDR) tuberculosis (TB) each year, with only a small proportion diagnosed and treated. This field has historically been neglected due to a perception that children with MDR-TB are challenging to diagnose and treat. Diagnostic and therapeutic developments in adults have improved paediatric management, yet further paediatric-specific research and wider implementation of evidence-based practices are required. Areas covered This review combines the ...
Source: Expert Review of Respiratory Medicine - September 25, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Risk of active tuberculosis among COPD patients treated with fixed combinations of long-acting beta2 agonists and inhaled corticosteroids
To investigate the incidence of active tuberculosis (TB) among COPD patients using fluticasone/salmeterol or budesonide/formoterol, and to identify any differences between these two groups of patients. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - September 25, 2020 Category: Infectious Diseases Authors: Tsan-Ming Huang, Kuan-Chih Kuo, Ya-Hui Wang, Cheng-Yi Wang, Chih-Cheng Lai, Hao-Chien Wang, Likwang Chen and Chong-Jen Yu Tags: Research article Source Type: research

Sudden death due to tension pneumothorax associated with pulmonary tuberculosis
AbstractA man in his seventies who lived alone was found dead in his home. Postmortem computed tomography (CT) performed prior to autopsy showed right-sided tension pneumothorax. Autopsy revealed an active pulmonary tuberculosis (TB) lesion. Macroscopic and histopathological findings showed pleural infiltration by TB lesions, suggesting that tension pneumothorax developed in association with TB infection. Routine postmortem CT performed prior to autopsy is useful in screening for TB because the presence of TB lesions can be confirmed from characteristic pulmonary findings. However, it may be difficult to identify tuberculo...
Source: Forensic Science, Medicine, and Pathology - September 24, 2020 Category: Forensic Medicine Source Type: research

Mycobacterium tuberculosis –Specific Antigen Rv3619c Effectively Alleviates Allergic Asthma in Mice
In this study, utilizing a Th1 delivery system to modulate the allergic airway inflammation in a Th2-driven model of asthma, we evaluated the efficacy of immunization with Mycobacterium tuberculosis-specific antigen Rv3619c, either alone or in combination with low dose dexamethasone. The rv3619c gene was cloned in an expression plasmid pGES-TH-1, expressed in Escherichia coli, and the recombinant protein Rv3619c was purified to homogeneity using affinity chromatography. Mice were immunized with the recombinant protein emulsified in Freund’s Incomplete Adjuvant (IFA) alone and in combination with low dose dexamethason...
Source: Frontiers in Pharmacology - September 24, 2020 Category: Drugs & Pharmacology Source Type: research

Complication of Mycobacterium tuberculosis treatment: Isoniazid-induced pneumonitis
A 33-year-old Central American migrant worker developed productive cough, fevers, night sweats, and weight loss over the course of 1 month. A chest X-ray showed a left upper lung zone opacity with cavitation. Computed tomography (CT) of the chest showed extensive, centrilobular tree-in-bud opacities primarily in the left upper lobe with small areas of cavitation (see Fig. 1a). A sputum culture was positive for Mycobacterium tuberculosis, pan-susceptible to minimum inhibitory concentrations of first-line medications for pulmonary tuberculosis. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - September 24, 2020 Category: Infectious Diseases Authors: Brian Cody Adkinson, Justin De La Fuente, Megan Ninneman, Zain Ahmad Chuadry, Brendan D. Adkinson, Laiqua Khalid Tags: Case Report Source Type: research

Label ‐free molecular detection of antibiotic susceptibility for Mycobacterium smegmatis using a low cost electrode format
This article is protected by copyright. All rights reserved (Source: Biotechnology and Applied Biochemistry)
Source: Biotechnology and Applied Biochemistry - September 24, 2020 Category: Biochemistry Authors: Fatma Dogan Guzel, Hamed Ghorbanpoor, Araz Norouz Dizaji, Iremnur Akcakoca, Yasin Ozturk, Tanil Kocagoz, Damion K Corrigan, Huseyin Avci Tags: Original Article Source Type: research

Calcium ATPase signaling: A must include mechanism in the Radar of therapeutics development against Tuberculosis
This article is protected by copyright. All rights reserved (Source: Biotechnology and Applied Biochemistry)
Source: Biotechnology and Applied Biochemistry - September 24, 2020 Category: Biochemistry Authors: Shivangi, Laxman S. Meena Tags: Review Article Source Type: research

Clinical Characteristics and Etiological Analysis of 133 Patients for Pulmonary Embolism Combined with Hemoptysis
AbstractBackgroundIn the patients with pulmonary embolism (PE), PE itself can cause hemoptysis and other reasons can also cause hemoptysis. Therefore, the clinical  characteristics and the causes of hemoptysis are lacking.MethodsA retrospective  analysis was performed that involved screening 583 PE patients and determining that hemoptysis occurred in 141 cases. Of these, 8 cases were omitted due to anticoagulation‐related hemoptysis or unavailable data, leaving 133 cases that were enrolled in final analysis (127 acute and 6 chronic cas e of PE). We classified the acute PE patients who combined with disease...
Source: The Clinical Respiratory Journal - September 24, 2020 Category: Respiratory Medicine Authors: YongWei Zou, Jun Duan, Xiao ‐Hui Wang, HuanHuan Yang, Jing Chi, Hong Chen Tags: ORIGINAL ARTICLE Source Type: research

Label ‐free molecular detection of antibiotic susceptibility for Mycobacterium smegmatis using a low cost electrode format
This article is protected by copyright. All rights reserved (Source: Biotechnology and Applied Biochemistry)
Source: Biotechnology and Applied Biochemistry - September 24, 2020 Category: Biochemistry Authors: Fatma Dogan Guzel, Hamed Ghorbanpoor, Araz Norouz Dizaji, Iremnur Akcakoca, Yasin Ozturk, Tanil Kocagoz, Damion K Corrigan, Huseyin Avci Tags: Original Article Source Type: research

Calcium ATPase signaling: A must include mechanism in the Radar of therapeutics development against Tuberculosis
This article is protected by copyright. All rights reserved (Source: Biotechnology and Applied Biochemistry)
Source: Biotechnology and Applied Biochemistry - September 24, 2020 Category: Biochemistry Authors: Shivangi, Laxman S. Meena Tags: Review Article Source Type: research

Case Report: Multidrug-Resistant Tuberculosis and COVID-19 Coinfection in Port-au-Prince, Haiti.
We describe a case of a patient with pulmonary MDR-TB and COVID-19 in Port-au-Prince, Haiti, and highlight the challenges and approach to managing a patient with both diseases. PMID: 32978934 [PubMed - as supplied by publisher] (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - September 24, 2020 Category: Infectious Diseases Authors: Vilbrun SC, Mathurin L, Pape JW, Fitzgerald D, Walsh KF Tags: Am J Trop Med Hyg Source Type: research

Biochemical characterization of ClpB protein from Mycobacterium tuberculosis and identification of its small-molecule inhibitors.
Abstract Tuberculosis, caused by pathogenic M. tuberculosis, remains a global health concern among various infectious diseases. Studies show that ClpB, a major disaggregase, protects the pathogen from various stresses encountered in the host environment. In the present study we have performed a detailed biophysical characterization of M. tuberculosis ClpB followed by a high throughput screening to identify small molecule inhibitors. The sedimentation velocity studies reveal that ClpB oligomerization varies with its concentration and presence of nucleotides. Further, using high throughput malachite green-based scre...
Source: International Journal of Biological Macromolecules - September 24, 2020 Category: Biochemistry Authors: Singh P, Khurana H, Yadav SP, Dhiman K, Singh P, Ashish, Singh R, Sharma D Tags: Int J Biol Macromol Source Type: research

Design and Synthesis of New Indanol-1,2,3-triazole Derivatives as Potent Antitubercular and Antimicrobial Agents.
Abstract In a search of new antitubercular agents, herein we have reported a series of new thirty-two indanol-1,2,3-triazole derivatives. The synthesized compounds were screened for their in vitro antitubercular and antimicrobial activities. Among the screened compounds, most of the compounds have displayed good antitubercular activity against Mycobacterium tuberculosis H37Rv. The compound 5g has been identified as potent antitubercular agent with MIC value 1.56 µM. The most active compounds of the series were further studied for their cytotoxicity against HEK 293 cells using MTT assay and found to be nontox...
Source: Bioorganic and Medicinal Chemistry Letters - September 24, 2020 Category: Chemistry Authors: Phatak PS, Bakale RD, Kulkarni RS, Dhumal ST, Dixit PP, Siva Krishna V, Sriram D, Khedkar VM, Haval KP Tags: Bioorg Med Chem Lett Source Type: research