Hb Westport [ β121 (GH4) Glu & gt;Asp; HBB: c.366A & gt;C]: A novel β-globin variant interfering with HbA1c measurement
CONCLUSIONS: Hb Westport is a novel β-globin variant that interferes with HbA1c measurement by Bio-Rad D-100 cation exchange HPLC, giving a falsely elevated result. This was clinically significant for our subject because the erroneously elevated HbA1c value was above the diabetes diagnostic threshold. Alternative methods for diabetes assessment should be considered in subjects with Hb Westport.PMID:35580651 | DOI:10.1016/j.clinbiochem.2022.05.003 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - May 17, 2022 Category: Biochemistry Authors: Jordyn A Moore Bobby V Li Darrell Wang Becca Chan Richard I King Chris M Florkowski Source Type: research

Comparison of fecal calprotectin and pancreatic elastase assays based on proficiency testing results
CONCLUSIONS: Both calprotectin and pancreatic elastase assays could be improved by standardization efforts. Given the clinical utility and our data demonstrating high inter-manufacturer variability, calprotectin should be prioritized over pancreatic elastase in standardization efforts.PMID:35580652 | DOI:10.1016/j.clinbiochem.2022.05.002 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - May 17, 2022 Category: Biochemistry Authors: Lisa M Johnson Michael Spannagl Nathalie Wojtalewicz J ürgen Durner Source Type: research

Calculated small dense LDL-cholesterol and its correlation with the atherogenic index of plasma
Ann Clin Biochem. 2022 May 14:45632221102767. doi: 10.1177/00045632221102767. Online ahead of print.NO ABSTRACTPMID:35574637 | DOI:10.1177/00045632221102767 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - May 16, 2022 Category: Biochemistry Authors: Sojit Tomo Shrimanjunath Sankanagoudar Ravindra Shukla Praveen Sharma Source Type: research

Calculated small dense LDL-cholesterol and its correlation with the atherogenic index of plasma
Ann Clin Biochem. 2022 May 14:45632221102767. doi: 10.1177/00045632221102767. Online ahead of print.NO ABSTRACTPMID:35574637 | DOI:10.1177/00045632221102767 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - May 16, 2022 Category: Biochemistry Authors: Sojit Tomo Shrimanjunath Sankanagoudar Ravindra Shukla Praveen Sharma Source Type: research

Calculated small dense LDL-cholesterol and its correlation with the atherogenic index of plasma
Ann Clin Biochem. 2022 May 14:45632221102767. doi: 10.1177/00045632221102767. Online ahead of print.NO ABSTRACTPMID:35574637 | DOI:10.1177/00045632221102767 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - May 16, 2022 Category: Biochemistry Authors: Sojit Tomo Shrimanjunath Sankanagoudar Ravindra Shukla Praveen Sharma Source Type: research

Serum human epididymis secretory protein 4 correlates with sepsis associated acute respiratory distress syndrome and 28-day mortality in critically ill patients
CONCLUSIONS: The concentration of serum HE4 in patients with sepsis-related ARDS was markedly increased and was significantly correlated with mortality, which suggests that serum HE4 could be a promising diagnostic and prognostic biomarker for ARDS in sepsis patients.PMID:35549539 | DOI:10.1177/00045632221103805 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - May 13, 2022 Category: Biochemistry Authors: Jinmei Luo Jingjing Liang Shaofang Wang Shaoqiong Huang Laizhi Zhou Yunfeng Shi Jingcong Zhang Yanhong Wang Ben-Quan Wu Laisheng Li Source Type: research

Changes and roles of IL-17A, VEGF-A and TNF- α in patients with cerebral infarction during the acute phase and early stage of recovery
CONCLUSION: After cerebral infarction, VEGF-A from the acute phase and IL-17A from the early stage of recovery may be important for nerve protection and repair; TNF-α plays a complex role within 35 days.PMID:35550786 | DOI:10.1016/j.clinbiochem.2022.05.001 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - May 13, 2022 Category: Biochemistry Authors: Panpan Xu Shuting Zhang Xiuli Kan Xianshan Shen Jing Mao Chuanqin Fang Xiaosan Wu Ju Qiu Ping Qu Peijun Qian Mei Shao Tingting Wu Yongfeng Hong Source Type: research

Serum human epididymis secretory protein 4 correlates with sepsis associated acute respiratory distress syndrome and 28-day mortality in critically ill patients
CONCLUSIONS: The concentration of serum HE4 in patients with sepsis-related ARDS was markedly increased and was significantly correlated with mortality, which suggests that serum HE4 could be a promising diagnostic and prognostic biomarker for ARDS in sepsis patients.PMID:35549539 | DOI:10.1177/00045632221103805 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - May 13, 2022 Category: Biochemistry Authors: Jinmei Luo Jingjing Liang Shaofang Wang Shaoqiong Huang Laizhi Zhou Yunfeng Shi Jingcong Zhang Yanhong Wang Ben-Quan Wu Laisheng Li Source Type: research

Changes and roles of IL-17A, VEGF-A and TNF- α in patients with cerebral infarction during the acute phase and early stage of recovery
CONCLUSION: After cerebral infarction, VEGF-A from the acute phase and IL-17A from the early stage of recovery may be important for nerve protection and repair; TNF-α plays a complex role within 35 days.PMID:35550786 | DOI:10.1016/j.clinbiochem.2022.05.001 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - May 13, 2022 Category: Biochemistry Authors: Panpan Xu Shuting Zhang Xiuli Kan Xianshan Shen Jing Mao Chuanqin Fang Xiaosan Wu Ju Qiu Ping Qu Peijun Qian Mei Shao Tingting Wu Yongfeng Hong Source Type: research

Serum human epididymis secretory protein 4 correlates with sepsis associated acute respiratory distress syndrome and 28-day mortality in critically ill patients
CONCLUSIONS: The concentration of serum HE4 in patients with sepsis-related ARDS was markedly increased and was significantly correlated with mortality, which suggests that serum HE4 could be a promising diagnostic and prognostic biomarker for ARDS in sepsis patients.PMID:35549539 | DOI:10.1177/00045632221103805 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - May 13, 2022 Category: Biochemistry Authors: Jinmei Luo Jingjing Liang Shaofang Wang Shaoqiong Huang Laizhi Zhou Yunfeng Shi Jingcong Zhang Yanhong Wang Ben-Quan Wu Laisheng Li Source Type: research

Comparison of blood collection tubes for 29 biochemical analytes in pediatric patients with central venous catheters
CONCLUSIONS: The use of LHTs for sample collection from pediatric patients with CVCs could be helpful for routine chemistry analyses. The results of potassium and total protein should be interpreted with consideration of the difference between serum and plasma samples.PMID:35545160 | DOI:10.1016/j.clinbiochem.2022.04.017 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - May 11, 2022 Category: Biochemistry Authors: Hyein Kang Hae Weon Cho John Hoon Rim Seung Min Hahn Jung Woo Han Sang-Guk Lee Chuhl Joo Lyu Jong-Baeck Lim Source Type: research

Comparison of blood collection tubes for 29 biochemical analytes in pediatric patients with central venous catheters
CONCLUSIONS: The use of LHTs for sample collection from pediatric patients with CVCs could be helpful for routine chemistry analyses. The results of potassium and total protein should be interpreted with consideration of the difference between serum and plasma samples.PMID:35545160 | DOI:10.1016/j.clinbiochem.2022.04.017 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - May 11, 2022 Category: Biochemistry Authors: Hyein Kang Hae Weon Cho John Hoon Rim Seung Min Hahn Jung Woo Han Sang-Guk Lee Chuhl Joo Lyu Jong-Baeck Lim Source Type: research

Rapid diagnostic strategies using high sensitivity troponin assays - what is the evidence and how should they be implemented?
Ann Clin Biochem. 2022 May 2:45632221100347. doi: 10.1177/00045632221100347. Online ahead of print.ABSTRACTThe introduction of high sensitivity measurement of cardiac troponin T (hs cTnT) and cardiac troponin I (hs cTnI) has given the laboratory the ability to measure very low levels of cardiac troponin. The limit of detection of these assays is well below the 99th percentile. These low levels can also be measured with small values of imprecision. A range of algorithms combining presentation measurement with very small repeat sample intervals, repeats at 1-2 hours have been developed. These are able to predict with accepta...
Source: Clinical Biochemistry - May 2, 2022 Category: Biochemistry Authors: Paul Collinson Ahmed Abdulmagid Dakshi Aleem Khand Source Type: research

A simple method modification to increase separation of 2- and 3-hydroxyglutaric acid by GC-MS for clinical urine organic acids analysis
Clin Biochem. 2022 Apr 30:S0009-9120(22)00119-9. doi: 10.1016/j.clinbiochem.2022.04.016. Online ahead of print.ABSTRACTUrine organic acids profiling by gas chromatography-mass spectrometry (GC-MS) is routinely performed in hospital biochemical genetics laboratories for the investigation of inborn errors of metabolism. In particular, accurate identification of urinary levels of 3-hydroxyglutaric acid (3-OHGA) is important for diagnosing glutaric aciduria type 1 (GA1), but can be challenging by routine GC-MS profiling analysis due to co-elution and spectral similarity with the isomer 2-hydroxyglutaric acid (2-OHGA). To impro...
Source: Clinical Biochemistry - May 2, 2022 Category: Biochemistry Authors: Joshua A Dubland Graham Sinclair Hilary Vallance Bojana Raki ć Source Type: research

Rapid diagnostic strategies using high sensitivity troponin assays - what is the evidence and how should they be implemented?
Ann Clin Biochem. 2022 May 2:45632221100347. doi: 10.1177/00045632221100347. Online ahead of print.ABSTRACTThe introduction of high sensitivity measurement of cardiac troponin T (hs cTnT) and cardiac troponin I (hs cTnI) has given the laboratory the ability to measure very low levels of cardiac troponin. The limit of detection of these assays is well below the 99th percentile. These low levels can also be measured with small values of imprecision. A range of algorithms combining presentation measurement with very small repeat sample intervals, repeats at 1-2 hours have been developed. These are able to predict with accepta...
Source: Clinical Biochemistry - May 2, 2022 Category: Biochemistry Authors: Paul Collinson Ahmed Abdulmagid Dakshi Aleem Khand Source Type: research