Early diagnosis of tuberculous peritonitis in peritoneal dialysis patients using the T-SPOT test
AbstractA 49-year-old man was admitted with peritonitis nine months after starting continuous ambulatory peritoneal dialysis (CAPD) for kidney failure. Ceftazidime and cefazolin were started. Peritoneal dialysate culture was negative for bacteria, but antibiotic treatment was continued because peritonitis improved. Twenty days later, the patient was discharged with no signs of peritonitis. However, 40-day culture of the original peritoneal dialysate detectedMycobacterium tuberculosis, and peritonitis recurred, leading to readmission. A T-SPOT test was performed and was positive in 4 days. Anti-tuberculosis therapy was st...
Source: CEN Case Reports - April 21, 2024 Category: Urology & Nephrology Source Type: research
Interpretable machine learning in predicting drug-induced liver injury among tuberculosis patients: model development and validation study
The objective of this research was to create and validate an interpretable prediction model for drug-induced liver injury (DILI) during tuberculosis (TB) treatment. (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - April 20, 2024 Category: Research Authors: Yue Xiao, Yanfei Chen, Ruijian Huang, Feng Jiang, Jifang Zhou and Tianchi Yang Tags: Research Source Type: research
GenoMycAnalyzer: a web-based tool for species and drug resistance prediction for Mycobacterium genomes
Drug-resistant tuberculosis (TB) is a major threat to global public health. Whole-genome sequencing (WGS) is a useful tool for species identification and drug resistance prediction, and many clinical laborator... (Source: BMC Genomics)
Source: BMC Genomics - April 20, 2024 Category: Genetics & Stem Cells Authors: Doyoung Kim, Jeong-Ih Shin, In Young Yoo, Sungjin Jo, Jiyon Chu, Woo Young Cho, Seung-Hun Shin, Yeun-Jun Chung, Yeon-Joon Park and Seung-Hyun Jung Tags: Software Source Type: research
Death after cure: mortality among pulmonary tuberculosis survivors in rural Uganda
This study aimed to determine the incidence and predictors of mortality among TB survivors at a rural tertiary hospital in Uganda. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 20, 2024 Category: Infectious Diseases Authors: Joseph Baruch Baluku, Brenda Namanda, Sharon Namiiro, Diana Karungi Rwabwera, Gloria Mwesigwa, Catherine Namaara, Bright Twinomugisha, Isabella Nyirazihawe, Edwin Nuwagira, Grace Kansiime, Enock Kizito, Mary G. Nabukenya-Mudiope, Moorine Penninah Sekadde, Tags: Short Communication Source Type: research
Transcriptional activation of the Mycobacterium tuberculosis virulence ‐associated small RNA MTS1338 by the response regulators DosR and PhoP
MTS1338 is an infection-induced small RNA found in pathogenic mycobacterial strains. It is highly accumulated in response to numerous stresses. Herein, we investigated how MTS1338 is regulated at the transcriptional level. Our findings reveal the interplay of DosR (a mycobacterial dormancy regulator) and PhoP (which regulates low pH-inducible genes) at the promoter region of theMTS1338 gene during transcriptional activation. MTS1338, a distinctive small RNA in pathogenic mycobacteria, plays a crucial role in host –pathogen interactions during infection. Mycobacterial cells encounter heterogeneous stresses in macrophages,...
Source: FEBS Letters - April 19, 2024 Category: Biochemistry Authors: Krishan Kumar,
Tanmay Dutta Tags: Research Letter Source Type: research
Genomic Interactions Between < em > Mycobacterium tuberculosis < /em > and Humans
Annu Rev Genomics Hum Genet. 2024 Apr 19. doi: 10.1146/annurev-genom-021623-101844. Online ahead of print.ABSTRACTMycobacterium tuberculosis is considered by many to be the deadliest microbe, with the estimated annual cases numbering more than 10 million. The bacteria, including Mycobacterium africanum, are classified into nine major lineages and hundreds of sublineages, each with different geographical distributions and levels of virulence. The phylogeographic patterns can be a result of recent and early human migrations as well as coevolution between the bacteria and various human populations, which may explain why many ...
Source: Annual Review of Genomics and Human Genetics - April 19, 2024 Category: Genetics & Stem Cells Authors: Prasit Palittapongarnpim Pornpen Tantivitayakul Pakorn Aiewsakun Surakameth Mahasirimongkol Bharkbhoom Jaemsai Source Type: research
Management of Constrictive Pericarditis : A study of 43 operated cases
Ann Cardiol Angeiol (Paris). 2024 Apr 18;73(3):101742. doi: 10.1016/j.ancard.2024.101742. Online ahead of print.ABSTRACTChronic constrictive pericarditis is a rare condition characterized by clinical signs of right heart failure, due to the symphysis of the two pericardial leaflets. Our study focused on a retrospective analysis of 43 CCP surgery observations collected over an 11-year period (2003-2013). The mean age of the patients was 32 years; 65% were male; exercise dyspnea (95%) was the most frequent sign. Two main etiologies were observed: tuberculosis 58% and idiopathic causes 42%. All of our patients received a subt...
Source: Annales de Cardiologie et d'Angeiologie - April 19, 2024 Category: Cardiology Authors: Hicham Wazaren Abdelmalik Idrissa Badre El Boussaadani Abderahmane Bakkali Source Type: research
Mincle as a potential intervention target for the prevention of inflammation and fibrosis (Review)
Mol Med Rep. 2024 Jun;29(6):103. doi: 10.3892/mmr.2024.13227. Epub 2024 Apr 19.ABSTRACTMacrophage‑inducible C‑type lectin receptor (Mincle) is predominantly found on antigen‑presenting cells. It can recognize specific ligands when stimulated by certain pathogens such as fungi and Mycobacterium tuberculosis. This recognition triggers the activation of the nuclear factor‑κB pathway, leading to the production of inflammatory factors and contributing to the innate immune response of the host. Moreover, Mincle identifies lipid damage‑related molecules discharged by injured cells, such as Sin3‑associated protein 130...
Source: Molecular Medicine Reports - April 19, 2024 Category: Molecular Biology Authors: Yuanxia Zou Jianchun Li Hongwei Su Nathupakorn Dechsupa Jian Liu Li Wang Source Type: research
Application of metagenomic next-generation sequencing in the diagnosis of Bartonella neuroretinitis: a case report and literature review
ConclusionmNGS, a fast and unbiased method, can be used to detectB. henselae (if present) in intraocular fluid samples.; however, the results should be interpreted together with the clinical symptoms and other auxiliary test results. (Source: Journal of Ophthalmic Inflammation and Infection)
Source: Journal of Ophthalmic Inflammation and Infection - April 19, 2024 Category: Opthalmology Source Type: research
Exploring the association between erythema multiforme and HIV infection: some mechanisms and implications
This article highlights the potential direct and indirect role that HIV infection may play in the development of EM and the clinical dilemma that arises in the management of HIV-infected patients with this condition. These patients may require additional medications to manage opportunistic infections, many of which can also trigger hypersensitivity reactions leading to EM.PMID:38637892 | PMC:PMC11027329 | DOI:10.1186/s12981-024-00607-6 (Source: Herpes)
Source: Herpes - April 18, 2024 Category: Infectious Diseases Authors: Shumani Charlotte Manenzhe Razia Abdool Gafaar Khammissa Sindisiwe Londiwe Shangase Mia Michaela Beetge Source Type: research
Exploring the association between erythema multiforme and HIV infection: some mechanisms and implications
This article highlights the potential direct and indirect role that HIV infection may play in the development of EM and the clinical dilemma that arises in the management of HIV-infected patients with this condition. These patients may require additional medications to manage opportunistic infections, many of which can also trigger hypersensitivity reactions leading to EM.PMID:38637892 | PMC:PMC11027329 | DOI:10.1186/s12981-024-00607-6 (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - April 18, 2024 Category: Infectious Diseases Authors: Shumani Charlotte Manenzhe Razia Abdool Gafaar Khammissa Sindisiwe Londiwe Shangase Mia Michaela Beetge Source Type: research
Modulators targeting protein-protein interactions in Mycobacterium tuberculosis
Microbiol Res. 2024 Mar 7;284:127675. doi: 10.1016/j.micres.2024.127675. Online ahead of print.ABSTRACTTuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (M. tuberculosis), mainly transmitted through droplets to infect the lungs, and seriously affecting patients' health and quality of life. Clinically, anti-TB drugs often entail side effects and lack efficacy against resistant strains. Thus, the exploration and development of novel targeted anti-TB medications are imperative. Currently, protein-protein interactions (PPIs) offer novel avenues for anti-TB drug development, and the study of...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Guofeng Luo Tianqi Ming Luchuan Yang Lei He Tao Tao Yanmei Wang Source Type: research
A robust computational quest: Discovering potential hits to improve the treatment of pyrazinamide-resistant Mycobacterium tuberculosis
This study utilizes a novel integration of computational techniques, including multiscale biomolecular and molecular dynamics simulations, physicochemical and medicinal chemistry predictions, quantum computations and virtual screening from the ZINC and Chembridge databases, to elucidate the resistance mechanism and identify lead compounds that have the potential to improve treatment outcomes for PZA-resistant MTB, namely ZINC15913786, ZINC20735155, Chem10269711, Chem10279789 and Chem10295790. These computational methods offer a cost-effective, rapid alternative to traditional drug trials by bypassing the need for organic s...
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Muhammad Shahab Gabriel Christian de Farias Morais Shopnil Akash Umberto Laino Fulco Jonas Ivan Nobre Oliveira Guojun Zheng Shahina Akter Source Type: research
In silico identification of phytochemical inhibitors for multidrug-resistant tuberculosis based on novel pharmacophore generation and molecular dynamics simulation studies
Multidrug-resistant tuberculosis (particularly resistant to pyrazinoic acid) is a life-threatening chronic pulmonary disease. Running a marketed regime specifically targets the ribosomal protein subunit-1 (Rps... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - April 18, 2024 Category: Chemistry Authors: Bader S. Alotaibi Tags: Research Source Type: research
Integrated single-cell transcriptome and T cell receptor profiling reveals defects of T cell exhaustion in pulmonary tuberculosis
Tuberculosis-affected lungs with chronic inflammation harbor abundant immunosuppressive immune cells but the nature of such inflammation is unclear. Dysfunction in T cell exhaustion, while implicated in chronic inflammatory diseases, remains unexplored in tuberculosis. Given that immunotherapy targeting exhaustion checkpoints exacerbates tuberculosis, we speculate that T cell exhaustion is dysfunctional in tuberculosis. Using integrated single-cell RNA sequencing and T cell receptor profiling we reported defects in exhaustion responses within inflamed tuberculosis-affected lungs. (Source: Journal of Infection)
Source: Journal of Infection - April 18, 2024 Category: Infectious Diseases Authors: Zilu Wen, Lin Wang, Hui Ma, Leilei Li, Laiyi Wan, Lei Shi, Hongwei Li, Hui Chen, Wentao Hao, Shu Song, Qinghua Xue, Yutong Wei, Feng Li, Jianqing Xu, Shulin Zhang, Ka-Wing Wong, Yanzheng Song Tags: Bacteria and Bacterial Diseases Source Type: research
