Mechanisms of Drug-Induced Tolerance in Mycobacterium tuberculosis.
Abstract SUMMARYSuccessful treatment of tuberculosis (TB) can be hampered by Mycobacterium tuberculosis populations that are temporarily able to survive antibiotic pressure in the absence of drug resistance-conferring mutations, a phenomenon termed drug tolerance. We summarize findings on M. tuberculosis tolerance published in the past 20 years. Key M. tuberculosis responses to drug pressure are reduced growth rates, metabolic shifting, and the promotion of efflux pump activity. Metabolic shifts upon drug pressure mainly occur in M. tuberculosis's lipid metabolism and redox homeostasis, with reduced tricarb...
Source: Clinical Microbiology Reviews - October 20, 2020 Category: Microbiology Authors: Goossens SN, Sampson SL, Van Rie A Tags: Clin Microbiol Rev Source Type: research

Peritoneal tuberculosis: A case report on a rare cause of tumor marker elevation
Publication date: Available online 20 October 2020Source: Case Reports in Women's HealthAuthor(s): Dilek Sen, Joshua Brunton, Landon Melchior, David Klein, Gillian H. Levy, Booth Wainscoat, Linus Chuang (Source: Case Reports in Womens Health)
Source: Case Reports in Womens Health - October 20, 2020 Category: OBGYN Source Type: research

Spontaneous Intestinal Perforation in Pregnancy from a Pre-Existing Postoperative Adhesion: A Case Report.
CONCLUSION: This case demonstrates that adhesions between the bowel and uterus from prior surgery may lead to spontaneous intestinal perforation as the uterus enlarges during pregnancy. As this diagnosis can be difficult because of imaging limitations and physiologic changes of pregnancy, it should be considered in cases of unremitting abdominal pain and vomiting. PMID: 33051169 [PubMed - as supplied by publisher] (Source: Journal of Obstetrics and Gynaecology Canada : JOGC)
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - October 20, 2020 Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research

Artificial Intelligence-Based Classification of Chest X-Ray Images into COVID-19 and Other Infectious Diseases.
Authors: Sharma A, Rani S, Gupta D Abstract The ongoing pandemic of coronavirus disease 2019 (COVID-19) has led to global health and healthcare crisis, apart from the tremendous socioeconomic effects. One of the significant challenges in this crisis is to identify and monitor the COVID-19 patients quickly and efficiently to facilitate timely decisions for their treatment, monitoring, and management. Research efforts are on to develop less time-consuming methods to replace or to supplement RT-PCR-based methods. The present study is aimed at creating efficient deep learning models, trained with chest X-ray images, fo...
Source: International Journal of Biomedical Imaging - October 20, 2020 Category: Radiology Tags: Int J Biomed Imaging Source Type: research

Pulmonary tuberculosis: Evaluation of current diagnostic strategy.
Authors: Gressens SB, Billard-Pomares T, LeBoité H, Cruaud P, Bouchaud O, Carbonnelle E, Méchaï F Abstract OBJECTIVE: To identify tools that will result in faster diagnosis, making the current pulmonary tuberculosis strategy more efficient Patients and methods: A 4-year (2015 - 2018) retrospective study. The gold standard for diagnosis was a positive culture from a respiratory specimen. All sputum, fibroscopy and post-fibroscopy specimens (for smear negative patients) were collected. Each specimen was analyzed through smear examination and culture. All nucleic acid amplification testing results w...
Source: Medecine et Maladies Infectieuses - October 20, 2020 Category: Infectious Diseases Tags: Med Mal Infect Source Type: research

India's coronavirus pandemic is leading to many more deaths from TB
The coronavirus pandemic has made it harder for people in India to access healthcare for tuberculosis and almost 88,000 additional deaths due to TB are expected this year (Source: New Scientist - Health)
Source: New Scientist - Health - October 20, 2020 Category: Consumer Health News Source Type: research

Adherence to Isoniazid Preventive Therapy among Under-Five Children in Contact with Adult Bacteriologically Confirmed Pulmonary Tuberculosis Patients: A Mixed-Method Study.
Authors: Seid G, Tsedalu T, Ayele M Abstract Background: The World Health Organization recommends that all children below the age of five who have household contact with an infectious tuberculosis case should receive isoniazid preventive treatment for at least six months after the active tuberculosis disease has been ruled out. This research aims to determine the adherence of children, eligible for isoniazid preventive treatment, to the treatment who had contact with pulmonary tuberculosis patients. Methods: A mixed study design was used to prospectively assess the adherence to IPT among children under the age ...
Source: International Journal of Microbiology - October 20, 2020 Category: Microbiology Tags: Int J Microbiol Source Type: research

CME-Sonografie 94: Nebennieren.
Abstract Adrenal glands are often not examined in abdominal ultrasound because it is thought that the adrenal glands cannot be visualized. The normal right adrenal gland can be represented in most cases and the left one very often. Sonography makes an important contribution to the diagnosis of adrenal diseases. In addition to bleeding and tuberculosis, there are benign tumors (adrenal adenomas), pheochromocytomas, and adrenal carcinomas. There are also adrenal metastases and lymphomas. PMID: 33050817 [PubMed - indexed for MEDLINE] (Source: Praxis)
Source: Praxis - October 20, 2020 Category: General Medicine Authors: Tuma J Tags: Praxis (Bern 1994) Source Type: research

Malaria and tuberculosis as diseases of neglected populations: state of the art in chemotherapy and advances in the search for new drugs.
ra EI Abstract Malaria and tuberculosis are no longer considered to be neglected diseases by the World Health Organization. However, both are huge challenges and public health problems in the world, which affect poor people, today referred to as neglected populations. In addition, malaria and tuberculosis present the same difficulties regarding the treatment, such as toxicity and the microbial resistance. The increase of Plasmodium resistance to the available drugs along with the insurgence of multidrug- and particularly tuberculosis drug-resistant strains are enough to justify efforts towards the development of n...
Source: Memorias do Instituto Oswaldo Cruz - October 20, 2020 Category: Infectious Diseases Authors: de Araújo RV, Santos SS, Sanches LM, Giarolla J, El Seoud O, Ferreira EI Tags: Mem Inst Oswaldo Cruz Source Type: research

[COVID-19, tuberculosis and induced mortality].
Authors: Underner M, Perriot J, Peiffer G, Jaafari N PMID: 33069503 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - October 20, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

GSE124688 Blood RNA signature predicts recent tuberculosis exposure in mice
Contributors : Russell C Ault ; Colwyn A Headley ; Alexander E Hare ; Bridget J Carruthers ; Asuncion Mejias ; Joanne TurnerSeries Type : Expression profiling by arrayOrganism : Mus musculusKnowing when a person was infected with Mycobacterium tuberculosis (M.tb) is critical as recent infection is the strongest clinical risk factor for progression to TB disease in immunocompetent individuals. However, time since M.tb infection is very difficult to determine in routine clinical practice. We determined whether gene expression patterns in blood RNA correlate with time since M.tb infection or exposure to develop a biomarker fo...
Source: GEO: Gene Expression Omnibus - October 20, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

Mucosal Therapy of Multi-Drug Resistant Tuberculosis With IgA and Interferon- γ
New evidence has been emerging that antibodies can be protective in various experimental models of tuberculosis. Here, we report on protection against multidrug-resistant Mycobacterium tuberculosis (MDR-TB) infection using a combination of the human monoclonal IgA 2E9 antibody against the alpha-crystallin (Acr, HspX) antigen and mouse interferon-gamma in mice transgenic for the human IgA receptor, CD89. The effect of the combined mucosal IgA and IFN-γ; treatment was strongest (50-fold reduction) when therapy was applied at the time of infection, but a statistically significant reduction of lung bacterial load was obs...
Source: Frontiers in Immunology - October 20, 2020 Category: Allergy & Immunology Source Type: research

Tuberculosis
The present issue of The Journal is devoted mainly to the subject of pulmonary tuberculosis, the one disease that is just now foremost among subjects of medical discussion. Probably nothing has stirred up the medical profession at any time during the past century as has Koch ’s discovery of the tubercle bacillus. The disease we have had always with us and the suspicion of its communicability was not new, but this scientific confirmation of the facts and the practical deductions therefrom have amply warranted enthusiasm. We know now that tuberculosis, which is responsi ble for so large a proportion of human mortality,...
Source: JAMA - October 20, 2020 Category: General Medicine Source Type: research

Transbuccal Delivery of Isoniazid: Ex Vivo Permeability and Drug-Surfactant Interaction Studies.
Abstract The oral administration of isoniazid (INH) may lead to discontinuation of tuberculosis treatment due to drug-related hepatotoxicity events, and thus, the transbuccal delivery of this drug was investigated, for the first time, as an alternative administration route. Ex vivo permeability assays were performed in Franz-type diffusion chambers, applying INH alone and in combination with sodium dodecyl sulfate (SDS) and sodium taurocholate (ST). After confirming the formation of micelle structures by dynamic light scattering analysis, UV-visible spectroscopy and zeta potential analyses were used to investigate...
Source: AAPS PharmSciTech - October 20, 2020 Category: Drugs & Pharmacology Authors: Kroth R, Argenta DF, Conte J, Amaral BR, Caon T Tags: AAPS PharmSciTech Source Type: research

The Role of Granzyme B Containing Cells in the Progression of Chronic Obstructive Pulmonary Disease.
Abstract Background: Lung inflammation plays a vital role in the pathogenesis of chronic obstructive pulmonary disease (COPD), but the characteristics of the inflammatory process remains unclear. There is growing interest in the role of granzyme B (GzmB) because CD8+ T cells can induce apoptosis of target cells by releasing GzmB, which in turn may cause tissue injury and remodeling. However, GzmB is also expressed by regulatory cells, which are able to suppress CD8+ T cell. The role of GzmB+ cells needs to be defined in COPD. Methods: GzmB+ and CD8+ cells on alveolar wall of surgically resected lungs of micro...
Source: Respiratory Care - October 20, 2020 Category: Respiratory Medicine Authors: Kim WD, Chi HS, Choe KH, Kim WS, Hogg JC, Sin DD Tags: Tuberc Respir Dis (Seoul) Source Type: research

Exploring anti-corruption, transparency, and accountability in the World Health Organization, the United Nations Development Programme, the World Bank Group, and the Global Fund to Fight AIDS, Tuberculosis and Malaria
Corruption is recognized by the global community as a threat to development generally and to achieving health goals, such as the United Nations Sustainable Development Goal # 3: ensuring healthy lives and prom... (Source: Globalization and Health)
Source: Globalization and Health - October 20, 2020 Category: International Medicine & Public Health Authors: Jillian Clare Kohler and Andrea Bowra Tags: Review Source Type: research

Mycobacterium tuberculosis PPE18 protein inhibits MHC class II antigen presentation and B cell response in mice.
This study may be useful in understanding host-pathogen interaction and open up directions of designing novel therapeutics targeting PPE18 to tackle this nefarious pathogen. This article is protected by copyright. All rights reserved. PMID: 33084017 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
Source: European Journal of Immunology - October 20, 2020 Category: Allergy & Immunology Authors: Dolasia K, Nazar F, Mukhopadhyay S Tags: Eur J Immunol Source Type: research

Rifampicin-Resistant Multidrug-Resistant Tuberculosis Cases in Selected Hospitals in Western Oromia, Ethiopia: Cross-Sectional Retrospective Study
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - October 19, 2020 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

Rapid Detection of Ethambutol-Resistant Mycobacterium tuberculosis from Sputum by High-Resolution Melting Analysis in Beijing, China
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - October 19, 2020 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

Tuberculosis/HIV co-infection: sociodemographic and health profile of users of a specialized center
Conclusion The knowledge of the epidemiological situation of tuberculosis/HIV co-infection enables the provision of subsides to rethink the activities of health care and to enhance public policies. (Source: Acta Paulista de Enfermagem)
Source: Acta Paulista de Enfermagem - October 19, 2020 Category: Nursing Source Type: research

A Glutamine Insertion at Codon 432 of RpoB Confers Rifampicin Resistance in Mycobacterium tuberculosis
Tuberculosis (TB) is an infectious respiratory disease caused by Mycobacterium tuberculosis and one of the top 10 causes of death worldwide. Treating TB is challenging; successful treatment requires a long course of multiple antibiotics. Rifampicin (RIF) is a first-line drug for treating TB, and the development of RIF-resistant M. tuberculosis makes treatment even more difficult. To determine the mechanism of RIF resistance in these strains, we searched for novel mutations by sequencing. Four isolates, CDC-1, CDC-2, CDC-3, and CDC-4, had high-level RIF resistance and unique mutations encoding RpoB G158R, RpoB V168A, RpoB S...
Source: Frontiers in Microbiology - October 19, 2020 Category: Microbiology Source Type: research

Costs incurred by patients with drug-susceptible pulmonary tuberculosis in semi-urban and rural settings of Western India
ConclusionsTreatment completion was high and the costs incurred by TB patients were low in this setting. However, negative financial consequences occur even in low-cost settings. The role of universal cash transfer programs in such settings requires further study. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - October 19, 2020 Category: Infectious Diseases Source Type: research

Predicting antimicrobial resistance using conserved genes
In this study, we explore the possibility of predicting AMR phenotypes using incomplete genome sequence data. Models were built from small sets of randomly-selected core genes after removing the AMR genes. ForKlebsiella pneumoniae,Mycobacterium tuberculosis,Salmonella enterica, andStaphylococcus aureus, we report that it is possible to classify susceptible and resistant phenotypes with average F1 scores ranging from 0.80 –0.89 with as few as 100 conserved non-AMR genes, with very major error rates ranging from 0.11–0.23 and major error rates ranging from 0.10–0.20. Models built from core genes have predic...
Source: PLoS Computational Biology - October 19, 2020 Category: Biology Authors: Marcus Nguyen Source Type: research

HIV and Tuberculosis Co-infection Among Migrants in Portugal: A Brief Study on Their Sociodemographic, Clinical, and Genomic Characteristics
AIDS Research and Human Retroviruses, Ahead of Print. (Source: AIDS Research and Human Retroviruses)
Source: AIDS Research and Human Retroviruses - October 19, 2020 Category: Infectious Diseases Authors: Ana Maria Tavares Marta Pingarilho Judite Batista Miguel Viveiros S ónia Dias Cristina Toscano Perp étua Gomes Ana B. Abecasis Source Type: research

Mycobacterium tuberculosis co-infection is associated with increased surrogate marker of the HIV reservoir
Tuberculosis (Tb) is the most frequent opportunistic infection among people living with HIV infection. The impact of Tb co-infection in the establishment and maintenance of the HIV reservoir is unclear. (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - October 19, 2020 Category: Infectious Diseases Authors: Jingna Xun, Tangkai Qi, Lei Zou, Qi Tang, Yinzhong Shen, Junyang Yang, Luman Xie, Yongjia Ji, Renfang Zhang, Li Liu, Jiangrong Wang, Corky Steinhart, Zhenyan Wang, Yang Tang, Wei Song, Jianjun Sun & hellip; Tags: Research Source Type: research

Accuracy of the tuberculosis point-of-care Alere determine lipoarabinomannan antigen diagnostic test using α-mannosidase treated and untreated urine in a cohort of people living with HIV in Guatemala
Improved point-of-care diagnostic tests for tuberculosis (TB) in severe immune suppressed people living with HIV (PLWH) are needed to decrease morbidity and mortality outcomes. The aim of the study is to evalu... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - October 19, 2020 Category: Infectious Diseases Authors: Juan Ignacio Garc ía, Johanna Meléndez, Rosa Álvarez, Carlos Mejía-Chew, Holden V. Kelley, Sabeen Sidiki, Alejandra Castillo, Claudia Mazariegos, Cesar López-Téllez, Diana Forno, Nancy Ayala, Joan-Miquel Balada-Llasat, Carlos Rodolfo Mejía-Villator Tags: Research Source Type: research

The association of household food insecurity and HIV infection with common mental disorders among newly diagnosed tuberculosis patients in Botswana.
CONCLUSIONS: Mental disorders may be affected by food insecurity among new tuberculosis patients, regardless of HIV status. PMID: 33070794 [PubMed - as supplied by publisher] (Source: Public Health Nutrition)
Source: Public Health Nutrition - October 19, 2020 Category: International Medicine & Public Health Authors: Wang Q, Dima M, Ho-Foster A, Molebatsi K, Modongo C, Zetola NM, Shin SS Tags: Public Health Nutr Source Type: research

Spectrum of Bacterial Colonization in Patients Hospitalized for Treatment of Multidrug-Resistant Tuberculosis
Microbial Drug Resistance, Ahead of Print. (Source: Microbial Drug Resistance)
Source: Microbial Drug Resistance - October 19, 2020 Category: Microbiology Authors: Dale Annear Razia Gaida Kierra Myburg John Black Ilse Truter Colleen Bamford Sharlene Govender Source Type: research

Implementation of homology based and non-homology based computational methods for the identification and annotation of orphan enzymes: using Mycobacterium tuberculosis H37Rv as a case study
Homology based methods are one of the most important and widely used approaches for functional annotation of high-throughput microbial genome data. A major limitation of these methods is the absence of well-ch... (Source: BMC Bioinformatics)
Source: BMC Bioinformatics - October 19, 2020 Category: Bioinformatics Authors: Swati Sinha, Andrew M. Lynn and Dhwani K. Desai Tags: Research article Source Type: research

Mammalian Atg8-family proteins are upstream regulators of the lysosomalsystem by controlling MTOR and TFEB.
In conclusion, mAtg8s, IRGM and STX17 control lysosomal biogenesis by their combined or individual effects on MTOR, TFEB, and PPP3/calcineurin, independently of their roles in the formation of autophagosomal membranes. PMID: 33070669 [PubMed - as supplied by publisher] (Source: Autophagy)
Source: Autophagy - October 19, 2020 Category: Cytology Authors: Kumar S, Jain A, Choi SW, Peixoto Duarte da Silva G, Allers L, Mudd MH, Peters RS, Anonsen JH, Rusten TE, Lazarou M, Deretic V Tags: Autophagy Source Type: research

An uncommon case of primary parotid tuberculosis in a paediatric patient
Oral Surgery, EarlyView. (Source: Oral Surgery)
Source: Oral Surgery - October 19, 2020 Category: ENT & OMF Authors: E. Rezende ‐Silva, L.A.M. Santana, Y.M.F. Costa, L.C.G. Ayres, W.M. Takeshita, C.L. Trento Tags: Letter To The Editor Source Type: research

Accuracy of the tuberculosis point-of-care Alere determine lipoarabinomannan antigen diagnostic test using α-mannosidase treated and untreated urine in a cohort of people living with HIV in Guatemala.
Accuracy of the tuberculosis point-of-care Alere determine lipoarabinomannan antigen diagnostic test using α-mannosidase treated and untreated urine in a cohort of people living with HIV in Guatemala. AIDS Res Ther. 2020 Oct 19;17(1):62 Authors: García JI, Meléndez J, Álvarez R, Mejía-Chew C, Kelley HV, Sidiki S, Castillo A, Mazariegos C, López-Téllez C, Forno D, Ayala N, Balada-Llasat JM, Mejía-Villatoro CR, Wang SH, Torrelles JB, Ikeda J Abstract BACKGROUND: Improved point-of-care diagnostic tests for tuberculosis (TB) in severe immune suppresse...
Source: AIDS Research and Therapy - October 19, 2020 Category: Infectious Diseases Authors: García JI, Meléndez J, Álvarez R, Mejía-Chew C, Kelley HV, Sidiki S, Castillo A, Mazariegos C, López-Téllez C, Forno D, Ayala N, Balada-Llasat JM, Mejía-Villatoro CR, Wang SH, Torrelles JB, Ikeda J Tags: AIDS Res Ther Source Type: research

Mycobacterium tuberculosis co-infection is associated with increased surrogate marker of the HIV reservoir.
CONCLUSIONS: Tb co-infection was associated with the increased surrogate marker of the HIV reservoir, while its mechanism warrants further examination. PMID: 33076959 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - October 19, 2020 Category: Infectious Diseases Authors: Xun J, Qi T, Zou L, Tang Q, Shen Y, Yang J, Xie L, Ji Y, Zhang R, Liu L, Wang J, Steinhart C, Wang Z, Tang Y, Song W, Sun J, Cheng J, Le X, Wu H, He X, Chen R, Chen J, Lu H Tags: AIDS Res Ther Source Type: research

Mutations in fbiD (Rv2983) as a novel determinant of resistance to pretomanid and delamanid in Mycobacterium tuberculosis.
Abstract The nitroimidazole pro-drugs delamanid and pretomanid comprise one of only two new antimicrobial classes approved to treat tuberculosis (TB) in 50 years. Prior in vitro studies suggest a relatively low barrier to nitroimidazole resistance in Mycobacterium tuberculosis, but clinical evidence is limited to date. We selected pretomanid-resistant M. tuberculosis mutants in two mouse models of TB using a range of pretomanid doses. The frequency of spontaneous resistance was approximately 10-5 CFU. Whole genome sequencing of 161 resistant isolates from 47 mice revealed 99 unique mutations, 91% of which occurred...
Source: Antimicrobial Agents and Chemotherapy - October 19, 2020 Category: Microbiology Authors: Rifat D, Li SY, Ioerger T, Shah K, Lanoix JP, Lee J, Bashiri G, Sacchettini J, Nuermberger E Tags: Antimicrob Agents Chemother Source Type: research

The Clinical Dose of Pretomanid: An Exposure-Response Perspective.
The objective of this work was to retrospectively evaluate that recommended dose by means of exposure-response (E-R) modeling applied to outcomes of both efficacy and safety. Cox proportional hazard modeling was used, with steady-state average pretomanid concentration as the exposure metric. The efficacy outcome was time to sputum culture conversion to negative (TSCC). The safety outcomes were times to first occurrence of adverse events in classes selected either from pretomanid's Investigator Brochure or from the NDA submission as recognized safety signals for pretomanid based on preclinical as well as clinical experience...
Source: Antimicrobial Agents and Chemotherapy - October 19, 2020 Category: Microbiology Authors: Nedelman JR, Salinger DH, Subramoney V, Woolson R, Wade K, Li M, Everitt D, Mendel CM, Spigelman M Tags: Antimicrob Agents Chemother Source Type: research

Risk of Serotonin Syndrome with Isoniazid.
Abstract Latent Mycobacterium tuberculosis (TB) infections are estimated to affect a quarter of the world's population,1 leading to 10 million TB cases and 1.2 million TB-related deaths in 2018.2…. PMID: 33077663 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - October 19, 2020 Category: Microbiology Authors: O'Brien ME, Gandhi RG, Kotton CN, Adamsick ML Tags: Antimicrob Agents Chemother Source Type: research

Crystal structures of salts of bedaquiline
Bedaquiline [systematic name: 1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol, C32H31BrN2O2] is one of two important new drugs for the treatment of drug-resistant tuberculosis (TB). It is marketed in the US as its fumarate salt {systematic name: [4-(6-bromo-2-methoxyquinolin-3-yl)-3-hydroxy-3-(naphthalen-1-yl)-4-phenylbutyl]dimethylazanium 3-carboxyprop-2-enoate, C32H32BrN2O2+ · C4H3O4 − }, and about a dozen other salts of bedaquiline have been described in patent literature, but none have so far been structurally described. In a first communication, we present the c...
Source: Acta Crystallographica Section C - October 19, 2020 Category: Chemistry Authors: Okezue, M. Smith, D. Zeller, M. Byrn, S.R. Smith, P. Bogandowich-Knipp, S. Purcell, D.K. Clase, K.L. Tags: bedaquiline bedaqulinium salt drug-resistant tuberculosis crystal structure research papers Source Type: research

Barriers and Strategies: A Review of Access to Affordable Multi-Drug Resistant Tuberculosis Medication in China
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - October 18, 2020 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

Tuberculosis in small ruminants and dromedary camels in Ethiopia: A systematic review and meta-analysis
Publication date: Available online 17 October 2020Source: Preventive Veterinary MedicineAuthor(s): Kassahun Asmare, Berhanu Sibhat, Kassa Demissie, Gezahegn Mamo, Eystein Skjerve, Gobena Amini (Source: Preventive Veterinary Medicine)
Source: Preventive Veterinary Medicine - October 18, 2020 Category: Veterinary Research Source Type: research

The burden of HIV and tuberculosis on the resuscitation area of an urban district-level hospital in Cape Town
Publication date: Available online 16 October 2020Source: African Journal of Emergency MedicineAuthor(s): Lynne Swarts, Sa'ad Lahri, Daniël J. van Hoving (Source: African Journal of Emergency Medicine)
Source: African Journal of Emergency Medicine - October 17, 2020 Category: Emergency Medicine Source Type: research

Detection of Mycobacterium Tuberculosis DNA in Buccal Swab Samples from Children in Lima, Peru
We examined Mycobacterium tuberculosis DNA detection from buccal swab samples collected from children in Lima, Peru. DNA was extracted and amplified via real-time polymerase chain reaction. Sensitivity was 21% (95% confidence interval [CI]: 7%–42%) in 24 culture-confirmed tuberculosis cases and 4.6% (95% CI: 1%–13%) in 65 clinically diagnosed unconfirmed cases. Sensitivity was highest for smear-positive tuberculosis. Specificity was 99% in the 199 controls (95% CI: 96%–100%). (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - October 17, 2020 Category: Infectious Diseases Tags: Brief Reports Source Type: research

The Epidemiology and Clinical Characteristics of Pediatric Tuberculosis in Denmark 2009–2014 Highlights Targets for Prevention
Background: In Western Europe, most pediatric tuberculosis (TB) cases occur among immigrants; however, data are rarely stratified by first/second-generation immigrants and many cases may be preventable. Methods: This was a nationwide study of children (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - October 17, 2020 Category: Infectious Diseases Tags: Original Studies Source Type: research

Increasing Tuberculosis Rates and Association With Migration in Children Living in Campania Region, Southern Italy: A 10-Year Cohort Study
Background: Italy is classified as a low tuberculosis (TB) incidence country (rate 6.5/100,000 inhabitants). However, the Campania Region Pediatric Reference Centre (CRRC) observed an increase in TB, contemporarily with a rise in migration. Our aim was to investigate trends in TB notification rates, association with migration, and changes in clinical outcomes of children living in Campania. Methods: We conducted a prospective cohort study (January 1, 2009–December 31, 2018), including children (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - October 17, 2020 Category: Infectious Diseases Tags: Original Studies Source Type: research

Completeness of tuberculosis case notifications in Germany in 2013 –2017: first results of an inventory study
Evaluating the completeness of tuberculosis (TB) notification data is important for monitoring of TB surveillance systems. We conducted an inventory study to calculate TB underreporting in Germany in 2013 –2017. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - October 17, 2020 Category: Infectious Diseases Authors: Teresa Domaszewska, Basel Karo, Ute Preuss, Christian Kollan, Annicka Reuss, Hans-Peter Blank, Bonita Brodhun, Barbara Hauer, Doris Altmann, Lena Fiebig, Walter Haas and Nita Perumal Tags: Research article Source Type: research

Knowledge, attitude and practice towards tuberculosis in Gambia: a nation-wide cross-sectional survey
Early diagnosis and treatment of tuberculosis (TB) are the mainstay of global and national TB control efforts. However, the gap between expected and reported cases persists for various reasons attributable to ... (Source: BMC Public Health)
Source: BMC Public Health - October 17, 2020 Category: Consumer Health News Authors: Adedapo Olufemi Bashorun, Christopher Linda, Semeeh Omoleke, Lindsay Kendall, Simon D. Donkor, Ma-Ansu Kinteh, Baba Danso, Lamin Leigh, Sheriff Kandeh, Umberto D ’Alessandro and Ifedayo Morayo O. Adetifa Tags: Research article Source Type: research

Gluteal abscess caused by Mycobacterium tuberculosis
(Source: Techniques in Coloproctology)
Source: Techniques in Coloproctology - October 17, 2020 Category: Surgery Source Type: research

Double trouble: Extrauterine epithelioid trophoblastic tumor with uterine choriocarcinoma - An autopsy report
We report such a case in a 24-year-old woman who presented with menorrhagia since 2 months and obstetric history of two abortions, one of which was a molar pregnancy. She was undergoing evaluation for carcinoma cervix and treatment for pulmonary tuberculosis from another hospital when she was admitted at our institute for further workup and treatment. However, she succumbed and an autopsy was performed. Histologic evaluation after the autopsy revealed uterine choriocarcinoma with metastatic epithelioid trophoblastic tumor (ETT) in the lung and spleen. (Source: Indian Journal of Cancer)
Source: Indian Journal of Cancer - October 17, 2020 Category: Cancer & Oncology Authors: Kusum Jashnani Alshifa Yagana Niraj Mahajan Source Type: research

Stealth Strategies of Mycobacterium tuberculosis for Immune Evasion.
Abstract Tuberculosis is a devastating disease causing high mortality all over the world, especially in the developing countries. Mycobacterium tuberculosis (M. tb) is the causative agent of tuberculosis which replicates in the intracellular environment of host macrophages. Although the host immune system is capable of completely eliminating the pathogen, co-evolution of M. tb with humans has resulted in its ability to hijack the host innate and adaptive immune systems in numerous ways. Limited recent progress has been made in the understanding of M. tb immune escape mechanisms, hence exploration of survival strat...
Source: Current Issues in Molecular Biology - October 17, 2020 Category: Molecular Biology Authors: Naeem MA, Ahmad W, Tyagi R, Akram Q, Younus M, Liu X Tags: Curr Issues Mol Biol Source Type: research

Developing health policies in patients presenting with SARS-CoV-2: consider tuberculosis
Publication date: November 2020Source: The Lancet Global Health, Volume 8, Issue 11Author(s): Karen H Keddy, Giovanni B Migliori, Martie Van Der Walt (Source: The Lancet Global Health)
Source: The Lancet Global Health - October 16, 2020 Category: International Medicine & Public Health Source Type: research

Cytisine for smoking cessation in patients with tuberculosis: a multicentre, randomised, double-blind, placebo-controlled phase 3 trial
Publication date: November 2020Source: The Lancet Global Health, Volume 8, Issue 11Author(s): Omara Dogar, Ada Keding, Rhian Gabe, Anna-Marie Marshall, Rumana Huque, Deepa Barua, Razia Fatima, Amina Khan, Raana Zahid, Sonia Mansoor, Daniel Kotz, Melanie Boeckmann, Helen Elsey, Eva Kralikova, Steve Parrott, Jinshuo Li, Anne Readshaw, Aziz Sheikh, Kamran Siddiqi, TB and Tobacco Consortium (Source: The Lancet Global Health)
Source: The Lancet Global Health - October 16, 2020 Category: International Medicine & Public Health Source Type: research