Linezolid resistance in Staphylococcus haemolyticus - Case series and review of literature.
This study emphasizes the judicious use of newer antibiotics to contain the spread of resistance. PMID: 31389316 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - August 7, 2019 Category: Infectious Diseases Authors: Gupta V, Gulati N, Sharma S, Gupta R, Soni A, Chander J Tags: Infect Disord Drug Targets Source Type: research

An integrative gene expression microarray meta-analysis identifies host factors and key signatures involved in Hepatitis B Virus infection.
Abstract Hepatitis B virus (HBV) is a global health concern. Viral and host factors orchestrate the natural history of HBV infection, but the impact of host factors that influence the clinical course of the disease remain poorly understood. The aim of this study was to identify host factors crucial to the HBV life cycle by conducting a meta-analysis utilizing public microarray datasets. An integrative meta-analysis of expression data from two microarray datasets of HBV-infected liver tissues and healthy uninfected livers was conducted to identify gene expression signatures and overlapping biological processes modu...
Source: Infectious Disorders Drug Targets - August 7, 2019 Category: Infectious Diseases Authors: Elmessaoudi-Idrissi M, Windisch MP, Kettani A, Altawalah H, Pineau P, Benjelloun S, Ezzikouri S Tags: Infect Disord Drug Targets Source Type: research

Effects of Highly Active Antiretroviral Therapy on Albuminuria in HIV-infected Persons.
Abstract BACKGROUND: Highly active antiretroviral therapy (HAART), especially tenofovir DF-containing regimens, has been implicated in albuminuria. OBJECTIVE: We prospectively evaluated the effects of HAART on albumin-to-creatinine ratios (ACRs) in antiretroviral-naïve HIV-infected individuals. METHODS: One hundred and two (102) newly diagnosed, antiretroviral-naïve, human immunodeficiency virus (HIV)-infected persons were treated with Tenofovir disoproxil fumarate/Emtricitabine/Efavirenz (TDF/FTC/EFV), n=33; Zidovudine/Lamivudine/Nevirapine (ZDV/3TC/NVP), n=53; and Zidovudine/Lamivudine/Efavir...
Source: Infectious Disorders Drug Targets - August 7, 2019 Category: Infectious Diseases Authors: Adedeji TA, Adebisi SA, Adedeji NO Tags: Infect Disord Drug Targets Source Type: research

Parasitic infections of wild boars (Sus scrofa) in Iran: a literature review.
CONCLUSION: This review sheds light on the veterinary and public health aspects of the parasitic diseases of wild boars in the country and alerts authorities for future preventive measures. PMID: 31322074 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - July 16, 2019 Category: Infectious Diseases Authors: Maleki B, Dalimi A, Majidiani H, Badri M, Gorgipour M, Khorshidi A Tags: Infect Disord Drug Targets Source Type: research

Medicinal plants with anti-Acanthamoeba activity: A systematic review.
CONCLUSIONS: Recent studies have shown that many natural compounds have high anti-parasitic properties and low toxicity. Our research team hopes that the information provided in present systematic review can improve of new experimental and clinical trials and herbal combination therapy.Further studies are needed to understand the molecular mechanisms in the anti-amoebic reactions of plant species and ocular toxicity of extracts in animal models. PMID: 31322072 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - July 15, 2019 Category: Infectious Diseases Authors: Parasitology T, Ghaffarifar F, Fakhar M, Saberi R Tags: Infect Disord Drug Targets Source Type: research

Tuberculosis and Diabetes Mellitus in Northwest of Iran.
CONCLUSION: Majority of DM-TB patients were over 50 years of age and also more than half of them were women. So it seems that for DM women over age 50, to detect tuberculosis, screening tests such as PPD may be necessary. PMID: 31322073 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - July 15, 2019 Category: Infectious Diseases Authors: Ozma MA, Rashedi J, Poor BM, Vegari A, Asgharzadeh V, Kafil HS, Kazemi A, Sahebi L, Asgharzadeh M Tags: Infect Disord Drug Targets Source Type: research

Clonal relatedness, phylotyping and antimicrobial susceptibility of extended-spectrum-beta-lactamase producing uropathogenic Escherichia coli isolates from outpatients and inpatients.
CONCLUSIONS: The results showed extreme genomic diversity among the ESBL-producing E. coli isolated from community and multiclonal dissemination of ESBL-producing E. coli isolated from hospital units. PMID: 31322075 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - July 15, 2019 Category: Infectious Diseases Authors: Azimzadeh N, Derakhshandeh A, Motamedifar M, Naziri Z Tags: Infect Disord Drug Targets Source Type: research

Toxin-Antitoxin Systems And Their Role In Maintaining The Pathogenic Potential Of Causative Agents Of Sapronoses.
Abstract In interepidemic periods, a sapronoses typically employs a variety of mechanisms for maintaining viability of its causative agent in terrestrial parasitic systems, associated with different adaptive strategies utilized by its populations to survive. Unlike spore-forming bacteria, causative agents of sapronoses use resistant cell forms, which is a viable but nonculturable (VBNC) state, and persistence. Implementation of these strategies is conditioned by effects of various stress factors of the habitat and is characterized by decreased metabolism, alteration of the morphology and physiology of bacterial ce...
Source: Infectious Disorders Drug Targets - July 15, 2019 Category: Infectious Diseases Authors: Andryukov BG, Somova LM, Timchenko NF, Bynina MP, Lyapun IN Tags: Infect Disord Drug Targets Source Type: research

Therapeutic value of Vitamin D as an adjuvant therapy in neonates with sepsis.
This study included 60 neonates with sepsis who were divided into 2 equal groups; group I: 30 neonates with sepsis who received antibiotic only, Group II: 30 neonates with sepsis who received antibiotic therapy and vitamin D. This study included also 30 healthy neonates as a control group. Serum level of 25 (OH) vitamin D and highly sensitive C reactive protein (hs-CRP) were immunoassayed. RESULTS: There is no significant difference between group I, II and controls as regard weight, gestational age, sex and mode of delivery. There were significant differences between group I and group II in sepsis score and hs-CRP aft...
Source: Infectious Disorders Drug Targets - June 26, 2019 Category: Infectious Diseases Authors: Hagag AA, El Frargy MS, Houdeeb HA Tags: Infect Disord Drug Targets Source Type: research

Monoterpenoid Geraniol improves anti-TB drug efficiency by interfering with lipidome and virulence of mycobacteria.
CONCLUSION: Taken together, the current study demonstrates the antimycobacterial mechanisms of Ger, which may be exploited as an effective candidate of pharmacological interest. PMID: 31241021 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - June 25, 2019 Category: Infectious Diseases Authors: Sharma S, Hameed S, Fatima Z Tags: Infect Disord Drug Targets Source Type: research

Submandibular Lymphadenitis in an Immunocompetent Female: Microbiological Confirmation is Need of the Hour.
We describe the case of a young, healthy female patient who developed cervical lymphadenitis and was given presumptive ATT. Microbiological examination of aspirate revealed M. fortuitum. This not only rectified the course of treatment resulting in complete cure, but also spared the patient from significant side effects of ATT. This case is an awakening call for clinicians to avoid presumptive ATT. PMID: 31218965 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - June 19, 2019 Category: Infectious Diseases Authors: Singhal L, Kumari P, Gupta M, Garg K, Chander J Tags: Infect Disord Drug Targets Source Type: research

Proposed guidelines for the management of ESBL in Prosthetic Joint Infections.
This study reviewed 21 patients in the literature with documented ESBL associated PJI. Literature suggests patients with ESBL PJI being stratified into either early infections (3 weeks), following which appropriate laboratory and imaging studies need to be completed. Favorable outcomes require a two-stage revision with an antibiotic impregnated spacer and a prolonged course of intravenous carbapenem antibiotic. PMID: 31203809 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - June 13, 2019 Category: Infectious Diseases Authors: Antony S, Khan I, Chowdhury O, Heydemann J, Antony N, Heydemann J, Isaac D Tags: Infect Disord Drug Targets Source Type: research

Clinical and Epidemiologic Features of Visceral Leishmaniasis in Children: A 6-year study from an Iranian referral hospital.
CONCLUSION: Leishmaniasis is regional disease, so that management and control of disease particularly in endemic area as well as detection of new emerging foci is recommended. PMID: 31203810 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - June 13, 2019 Category: Infectious Diseases Authors: Abdolsalehi M, Pourakbari B, Mahmoudi S, Moradzadeh M, Keshavarz H, Mamishi S Tags: Infect Disord Drug Targets Source Type: research

In silico T-cell and B-cell Epitope Based Vaccine Design Against Alphavirus Strain of Chikungunya.
CONCLUSION: On the basis of this computational analysis, it is suggested that these predicted epitopes can be used as a remedy against Alphavirus strain of chikungunya. Further laboratory experiments can be conducted to determine the efficacy and stability of this work. PMID: 31109281 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - May 20, 2019 Category: Infectious Diseases Authors: Jadoon MH, Rehman Z, Khan A, Rizwan M, Khan S, Mehmood A, Munir A Tags: Infect Disord Drug Targets Source Type: research

Molecular Detection of Carbapenem Resistance in Acinetobacter Baumannii Isolated From Patients in Khorramabad City, Iran.
CONCLUSION: Due to the high resistance of Acinetobacter baumannii and easy to release and the ability to transfer resistance genes, resistance control methods should be used in hospital area disinfection and the observance of hygiene tips by the personnel on the one hand and reduction of antibiotic use on the other should be taken into account. PMID: 31099322 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - May 17, 2019 Category: Infectious Diseases Authors: Babaie Z, Delfani S, Rezaei F, Norolahi F, Mahdian S, Shakib P Tags: Infect Disord Drug Targets Source Type: research

Hemodynamic Changes of Hepatic & Renal vessels In Systemic Bacterial Infection with Fever in HCV Related Cirrhosis.
CONCLUSION: Systemic bacterial infection with fever can affect hepatic haemodynamics leading to aggravation of portal hypertension and increasing the risk of complications as variceal bleeding and hepatic encephalopathy and also can affect renal haemodynamics with risk of renal impairment. PMID: 31057113 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - May 5, 2019 Category: Infectious Diseases Authors: Helal EM, Sharaf-Eldin M, Abou El Azm AR, Badr Eldin NM, Dawoud MM, Abd-Elsalam S, Ziada DH Tags: Infect Disord Drug Targets Source Type: research

Proposals for Amendments in the Diagnosis and Treatment of Encephalitis caused by Free-living Amoebae.
Abstract Encephalitis caused by Free-living amoebae (FLA) has a mortality rate of around 95-98%, a fraction that has not changed in the past decades. Pathogenic FLA include Acanthamoeba, Balamuthia mandrillaris, and Naegleria fowleri that are known to target the brain after an extra cerebral infection in the case of Acanthamoeba and Balamuthia mandrillaris, or directly the brain, as in the case of the Naegleria fowleri. The Acanthamoeba spp. and Balamuthia mandrillaris cause granulomatous amoebic encephalitis (GAE) while Naegleria fowleri, the so termed "brain eating amoeba" causes primary amoebic mening...
Source: Infectious Disorders Drug Targets - April 5, 2019 Category: Infectious Diseases Authors: Baig AM Tags: Infect Disord Drug Targets Source Type: research

Effect of Ursodeoxycholic acid, Lawsonia inermis and Achillea millefolium extracts on Hydatid Cyst Protoscolices.
CONCLUSION: Lawsonia inermis and Achillea millefolium extracts are a potent protoscolicidal which may be used as a scolicidal agent during the surgery. PMID: 30950359 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - April 5, 2019 Category: Infectious Diseases Authors: Sanei B, Tavakoli P, Hadipour M, Darani HY Tags: Infect Disord Drug Targets Source Type: research

Therapeutic exploitation of viral interference.
Abstract Viral interference, originally, referred to a state of temporary immunity, whereby infection with a virus limits replication or production of a second infecting virus. However, replication of a second virus could also be dominant over the first virus. In fact, dominance can alternate between the two viruses. Expression of type I interferon genes is many times upregulated in infected epithelial cells. Since the interferon system can control most, if not all, virus infections in the absence of adaptive immunity, it was proposed that viral induction of a nonspecific localized temporary state of immunity may ...
Source: Infectious Disorders Drug Targets - April 5, 2019 Category: Infectious Diseases Authors: Kovesdi I, Bakacs T Tags: Infect Disord Drug Targets Source Type: research

Emerging of Heteroresistance Mycobacterium tuberculosis in Saudi Arabia.
CONCLUSION: The detection of hetroresistance mutations could guide the initiating of an appropriate regimen of treatment. PMID: 30914036 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - March 26, 2019 Category: Infectious Diseases Authors: Abakur EHA, Alnour TM, Abuduhier F, Albalawi FM, Alfifi KA Tags: Infect Disord Drug Targets Source Type: research

Application of SRMS 154 as sustained release matrix for the delivery of stavudine: In vitro and in vivo evaluation and effect of Poloxamer 188 on the properties of the tablets.
Abstract CONTEXT: Stavudine is an antiretroviral therapy with so many side effects and has short half life of 1.5 h. It degrades to thymine under hydrolytic, oxidative and photolytic conditions hence, has major formulation challenges. OBJECTIVES: To formulate sustained release lipid based stavudine and to study the properties of the formulations by in vitro and in vivo methods. MATERIALS AND METHOD: Stavudine tablets were formulated by molding using validated tablets moulds. The carrier used were solidified reverse micellar solution (SRMS) made up of varying ratios of hydrogenated palm oil and Phospholip...
Source: Infectious Disorders Drug Targets - March 13, 2019 Category: Infectious Diseases Authors: Chime SA, Attama AA, Onunkwo GC Tags: Infect Disord Drug Targets Source Type: research

Giardia lamblia subtypes and their relationship with clinical symptoms in patients with giardiasis.
Abstract Giardia lamblia has proved to be the most common intestinal protozoan parasite in humans that causes giardiasis. Given the high mutations in the genome of this parasite, the present study was conducted to determine the prevalence of Giardia lamblia subtypes and their relationship with clinical symptoms in patients who appear to have giardiasis. In 69 stool specimens with an appropriate number of giardia cysts, the DNA was first purified, and the genotype was then determined based on the glutamate dehydrogenase (gdh) gene sequence using PCR-RFLP. Data were collected on the clinical symptoms of the patients...
Source: Infectious Disorders Drug Targets - March 13, 2019 Category: Infectious Diseases Authors: Viesy S, Abdi J, Haghani K, Valizadeh R Tags: Infect Disord Drug Targets Source Type: research

Multiplex PCR is Rapid, simple and cheap method for direct diagnosis of M. tuberculosis from sputum samples.
CONCLUSION: Multiplex PCR method using two different sets of primers in combination of other diagnostic tools such as X-Rays and smear Microscopy are cheap, rapid and reliable methods for diagnosis of M. tuberculosis from clinical samples and able to identify most of smear positive cases with valuable accuracy. PMID: 30864512 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - March 11, 2019 Category: Infectious Diseases Authors: Alnour T, Abuduhier F, Khatatneh M, Albalawi F, Alfifi K, Silvala B Tags: Infect Disord Drug Targets Source Type: research

Multiple Myeloma or Brucellosis: ACase Report.
CONCLUSIONS: Brucella infection may cause a severe disease, mimicking a primary hematological disease, which could complicate the correct diagnosis. In brucellosis cases, due to the wide range of symptoms, in addition to cultivation and serological methods, molecular methods should also be used to prevent inappropriate diagnosis and additional costs. PMID: 30848218 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - March 7, 2019 Category: Infectious Diseases Authors: Rahdar HA, Kodori M, Salehi MR, Doomanlou M, Karami-Zarandi M, Jasemi S, Feizabadi MM Tags: Infect Disord Drug Targets Source Type: research

Preface.
Abstract PMID: 30774046 [PubMed - in process] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - February 20, 2019 Category: Infectious Diseases Authors: Sabatier JM Tags: Infect Disord Drug Targets Source Type: research

Non-compliance to mass drug administration associated with the low perception of the community members about their susceptibility to lymphatic filariasis in Ankobra, Ghana.
CONCLUSION: Health education about the susceptibility of residents getting LF disease in endemic community must be intensified to improve compliance to MDA medication ingestion and thus meet the Global Elimination of Lymphatic Filariasis by 2020. PMID: 30727921 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - February 6, 2019 Category: Infectious Diseases Authors: Dicko I, Coulibaly YI, Sangaré M, Sarfo B, Nortey PA Tags: Infect Disord Drug Targets Source Type: research

Plasmid-Mediated Quinolone Resistance in Pseudomonas aeruginosa Isolated from Burn Patients in Tehran, Iran.
CONCLUSION: The findings of the present study indicated the presence of aac(6')-Ib-cr variant and lack of the contribution of qnr and qepA in the emergence of resistance to quinolones in P. aeruginosa isolated from burn patients. Considering the importance of clonal spread of these resistant isolates and their significant role in the development of clinical infections, especially in patients with burns, more attention should be paid to the prevention of the dissemination of these resistant isolates. PMID: 30727922 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - February 6, 2019 Category: Infectious Diseases Authors: Molapour A, Peymani A, Saffarain P, Habibollah-Pourzereshki N, Rashvand P Tags: Infect Disord Drug Targets Source Type: research

Molecular Binding and Simulation Studies of Staphylococcus aureus Superantigens with Flavonoid Compounds.
Abstract Superantigens of Staphylococcus aureus namely enterotoxin A, exfoliative toxin A, and Toxic shock syndrome toxin-1 cause detrimental effects on the cells of immune system. In this work, the toxins were downloaded from Protein DataBank database and energy minimized using KoBaMIN server. Forty flavonoids compounds were identified by pubchem compound database through extensive literature study and their 3D structures were obtained by submitting SMILES to CORINA tool. Based on Lipinski's rule of five the molecules were filtered resulting in 27 compounds. Molecular docking was performed for identifying the bin...
Source: Infectious Disorders Drug Targets - February 6, 2019 Category: Infectious Diseases Authors: Mohan R, Venugopal S Tags: Infect Disord Drug Targets Source Type: research

Antimicrobial Resistance and Presence of Cass 1 Integrons Among Different Serotypes of Salmonella spp. Recovered From Children With Diarrhea In Tehran, Iran.
CONCLUSION: The high frequency of integron class 1 gene in MDR Salmonella strains indicates that these mobile genetic elements are versatile among different Salmonella serotypes, and associate with reduced susceptibility to many antimicrobials. PMID: 30706828 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - January 30, 2019 Category: Infectious Diseases Authors: Eshaghi Zadeh SH, Fahimi H, Fardsanei F, Soltan Dallal MM Tags: Infect Disord Drug Targets Source Type: research

Allopurinol and loss of consciousness in a 78-old year man suffering from gout.
In this report, we are representing a case of drug-induced meningitis in a senile man who ended up in ICU due to the remarkably reduced state of consciousness. PMID: 30686265 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - January 27, 2019 Category: Infectious Diseases Authors: Arian M, Rad MA, Moghaddam AB, Firoozi A, Jami M Tags: Infect Disord Drug Targets Source Type: research

Post-Traumatic Endophthalmitis due to Acinetobacter radioresistens: Virulence Potential of Commensal Bacteria.
We describe the first case of post-traumatic endophthalmitis caused by otherwise non-pathogenic A. radioresistens, in India. Gram-negative coccobacilli were observed on Gram stain and culture of vitreous fluid specimen, and identified biochemically as Acinetobacter spp. The species was identified by Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS). The pathogenic potential of 'commensal' A. radioresistens and its role in dissemination of carbapenem resistance genes underlines the importance of species-level identification in Acinetobacter infections. PMID: 30674268 [PubMed - ...
Source: Infectious Disorders Drug Targets - January 23, 2019 Category: Infectious Diseases Authors: Datta P, Gupta M, Kumari P, Gupta V, Narang S, Chander J Tags: Infect Disord Drug Targets Source Type: research

Hepatitis C virus: Efficacy of new DAAs Regimens.
CONCLUSION: HCV treatment has improved dramatically. Since that time, there are multiple approved oral therapies all with high efficacy. The most important factor which should be considered during choosing appropriate therapy is to ensure that it covers the viral genotype of the infected patients. PMID: 30663575 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - January 20, 2019 Category: Infectious Diseases Authors: Mohamed AA, El-Toukhy NER, Said EM, Gabal HMR, AbdelAziz H, Doss W, El-Hanafi H, El Deeb HH, Mahmoud S, Elkadeem M, Shalby HS, Abd-Elsalam S Tags: Infect Disord Drug Targets Source Type: research

Phenotypic and Molecular Survey of Metallo-beta-lactamase-producing Pseudomonas aeruginosa Isolated from Patients with Nosocomial and Non-Nosocomial Infections.
CONCLUSION: Presence of MBL-producing P. aeruginosa strains and blaIMP genes were proved in this study; thus more precaution should be taken in administration of carbapenem antibiotics to patients. PMID: 30659550 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - January 18, 2019 Category: Infectious Diseases Authors: Rouhi S, Ramazanzadeh R Tags: Infect Disord Drug Targets Source Type: research

Legionella pneumonia in pregnancy: A case report and review of the literature.
Abstract L. pneumophila is an unusual cause of pneumonia with a prevalence of 2.7%, and it is even more uncommon in pregnancy [1]. To date, only 11 cases of Legionnaire's Disease in pregnancy have been reported [2-11], though this small number could possibly be attributed to underdiagnoses and underdocumentation. In this paper, we present a 31-year-old Hispanic female, gravida 4, para 1 from the southwest United States who presented with a 3 week history of fever, worsening cough, dyspnea on exertion, and hypoxemia. Chest x-ray showed bibasilar infiltrates, with positive serology for legionella IgM and IgG (1:250 ...
Source: Infectious Disorders Drug Targets - January 18, 2019 Category: Infectious Diseases Authors: Kleinberg KA, Antony SJ Tags: Infect Disord Drug Targets Source Type: research

Distribution of genes encoding iron uptake systems among the Escherichia coli isolates from foodstuffs compared to Escherichia coli isolated from clinical specimens.
CONCLUSION: Our results showed that the prevalence of E. coli isolates with iut A and iuc A genes was relatively higher compared to many previous studies. The existence of these genes in E. coli strains is likely to be related with pathogenicity in those strains, which requires further studies in the future. PMID: 30659552 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - January 18, 2019 Category: Infectious Diseases Authors: Mahmoudi H, Hossainpour H, Moradi M, Alikhani MY Tags: Infect Disord Drug Targets Source Type: research

Trichomonas Vaginalis Infection among Women Attending laboratory Centers in Ilam, Iran.
Abstract Trichomoniasis is known as a common venereal disease. It is estimated that 180 million people in the world are infected with this disease. The present study was conducted to estimate the prevalence of (Trichomonas vaginalis) T. vaginalis among women who were referred to the central laboratory in Ilam. In this cross-sectional study, 481 women with suspicious symptoms of trichomoniasis were selected during the first six months of 2015 in the central laboratory and Shahid Mostafa laboratory in Ilam, Iran. All patients were referred to the labs by gynecologists. Sterile swabs were used to collect direct smear...
Source: Infectious Disorders Drug Targets - January 17, 2019 Category: Infectious Diseases Authors: Nikpay S, Otaghi M, Azami M, Karimi M, Abdi J Tags: Infect Disord Drug Targets Source Type: research

Hydroxyenone Derivatives: In vitro Anti-malarial and Docking Studies against P. falciparum.
Abstract A series of 1-{2-(prop-2-ynyloxy)aryl}-3-hydroxy-3-(4'-trifluoromethyl-phenyl)prop-2-en-1-ones obtained by photo-irradiation of 2-{2-(prop-2-ynyloxy)benzoyl}-3-(4-trifluoromethyl-phenyl)oxiranes (that were characterized by spectral studies: FT-IR, 1H NMR, 13C NMR and Mass analysis) was screened for the anti-malarial activity by evaluating against chloroquine-sensitive P. falciparum (CD7). The molecular docking studies using AutoDock Vina were also performed to further ascertain the efficacy of these compounds with PDB:4ORM. Among these, the hydroxyenone derivatives 2b, 2c and 2a exhibited very potent anti...
Source: Infectious Disorders Drug Targets - January 15, 2019 Category: Infectious Diseases Authors: Dalal A, Kumar P, Khanna R, Kumar D, Paliwal D, Kamboj RC Tags: Infect Disord Drug Targets Source Type: research

PZQ therapy: how close are we in the development of effective alternative anti-schistosomal drugs?
Abstract Today schistosomiasis, caused mainly by the three major schistosome species (S. mansoni, S. haematobium and S. japonicum), has for many decades and still continues to be on a rapid and swift rise globally, claiming thousands of lives every year and leaving 800 million people at the risk of infection. Due to the high prevalence of this disease and the steady increase in infection rates, praziquantel (PZQ) remains the only effective drug against this acute disease although it has no effect on the juvenile schistosome parasite. However, no significant approaches have been made in recent years in the discover...
Source: Infectious Disorders Drug Targets - December 31, 2018 Category: Infectious Diseases Authors: Aruleba RT, Adekiya TA, Oyinloye BE, Masamba P, Mbatha LS, Pretorius A, Kappo AP Tags: Infect Disord Drug Targets Source Type: research

Stopping of the downtrend of Tuberculosis in Iran, a systematic review of associated risk factors.
In conclusion, the increase in predisposing risk factors for catching TB, especially the migration and Beijing strain, shows that in the absence of accurate monitoring, TB cases will increase in the near future in Iran. PMID: 30592256 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - December 28, 2018 Category: Infectious Diseases Authors: Fadaee M, Rashedi J, Arabi S, Poor BM, Kafil HS, Pourostadi M, Kazemi A, Asgharzadeh M Tags: Infect Disord Drug Targets Source Type: research

Characterization of Antibacterial-Producing Endophytic Fungi of Syzygiumpolyanthum Leaves.
This study aimed to characterize morphologically, microscopically, and molecularly the antibacterial-producing endophytic fungi of Syzygiumpolyanthum leaves.The isolation of endophytic fungi was done by fragment planting method on PDA medium. The antibacterial screening was using the antagonistic test as the first screening and followed by the disc diffusion test method. The morphological characterization was based on isolate's mycelia color, growth pattern, margin, and surface texture of the colony, while the microscopic characterization was based on its hyphae characteristic. The molecular characterization of the isolate...
Source: Infectious Disorders Drug Targets - December 26, 2018 Category: Infectious Diseases Authors: Burhamzah R, Alam G, Rante H Tags: Infect Disord Drug Targets Source Type: research

Association Between Immunologic and Virologic Functioning and Health-Related Quality of Life Among People Living with HIV, Tehran, Iran.
Conclusion: Knowing the association between current CD4 count and health-related quality of life, adherence to ARV medication might be a motivator for PLWH to enhance their health-related quality of life. PMID: 30574855 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - December 21, 2018 Category: Infectious Diseases Authors: Ghodrati S, Shahabinezhad Z, Alinaghi SAS Tags: Infect Disord Drug Targets Source Type: research

Association of Low Vitamin D Status with Complications of HIV and AIDS: A Literature Review.
Abstract With the advent of combination antiretroviral therapy (cART) the survival of HIV patients have improved dramatically, but the complications of the disease and treatment have become an important issue in the management of HIV patients. Vitamin-D deficiency is common in HIV patients. Low vitamin-D is associated with different comorbidities in the HIV uninfected general population. In this review, we first briefly describe vitamin D synthesis and mechanism of action and we focus on the epidemiological and clinical data dealing with the relationship between vitamin D deficiency in HIV infection with several c...
Source: Infectious Disorders Drug Targets - December 21, 2018 Category: Infectious Diseases Authors: Chokuda E, Reynolds C, Das S Tags: Infect Disord Drug Targets Source Type: research

Outcomes of Treatment and Predictors of Response to Sofosbuvir plus Simeprevir in Hepatitis C Virus with Genotype-4 Infection.
CONCLUSIONS: Twelve weeks regimen of sofosbuvir plus simeprevir was considered to be safe and tolerable in treatment of HCV genotype 4; also it was associated with high SVR (97.6%). PMID: 30569878 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - December 17, 2018 Category: Infectious Diseases Authors: Ahmed OA, Elsebaey MA, Fouad MHA, Elkadeem M, Badawi R, Khayyal A, Soliman S, Negm MS, Abd-Elsalam S Tags: Infect Disord Drug Targets Source Type: research

Synthesis, biological evaluation and molecular docking studies of new pyrazolines as an antitubercular and cytotoxic agents.
Abstract A series of new pyrazolines containing 2,5-dichloro-3-acetylthiophene chalcone moiety (PZT1-PZT20) have been synthesized, characterized by 1HNMR and 13CNMR and evaluated for them in vitro antitubercular activity against M. tuberculosis H37Rv strain and in vitro anticancer activity against DU-145 prostate cancer cell lines. Majority of screened compounds have displayed potential activity against Mycobacterium tuberculosis H37Rv(MTB) strain and anticancer activity against DU-149 prostate cancer cell lines. Among the series, compound PZT5 with 2", 4"-dichlorophenyl group at 5-position on the pyrazo...
Source: Infectious Disorders Drug Targets - December 17, 2018 Category: Infectious Diseases Authors: Lokesh BVS, Prasad YR, Shaik AB Tags: Infect Disord Drug Targets Source Type: research

Incidence and risk factors of brucellosis in Kermanshah province, Iran during 2010-2014.
CONCLUSION: Risk factors of brucellosis in our study were like other studies, but in more than one- third of the patients, no risk factor was identified. Lack of livestock vaccination history and incomplete registered data about other possible transmission routes of transmission was the most limitation in the study. PMID: 30539704 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - December 11, 2018 Category: Infectious Diseases Authors: Rajabi J, Hamidi-Farahani R, Mansouri F, Soleiman-Meigooni S Tags: Infect Disord Drug Targets Source Type: research

Target discovery for new antitubercular drugs using a large dataset of growth inhibitors from PubChem.
Abstract The number of drugs available for treatment of active tuberculosis are diminishing due to increased multidrug resistance selection in Mycobacterium tuberculosis leading to multiple (MDR) and extensively (XDR) resistant strains. Also, TB is treated with multiple drugs to minimize further resistance development, mandating a sustained effort to identify new lead compounds for treating drug resistant TB, and shortening time to cure for all TB infections. High throughput screening, a well-known approach to discovery of new leads, is conducted in two basic modes 1) using whole cells and screening for inhibition...
Source: Infectious Disorders Drug Targets - December 5, 2018 Category: Infectious Diseases Authors: Goldman RC Tags: Infect Disord Drug Targets Source Type: research

High-level aminoglycoside resistance in Enterococcus faecalis and Enterococcus faecium; as a serious threat in hospitals.
Abstract The present work aimed to evaluate the frequency of aminoglycoside-modifying enzymes encoding genes in the E. faecalis and E. faecium and their antibiotic resistance profile. A total of 305 different clinical samples were subjected for identification and antibiotic susceptibility test. High level aminoglycoside resistance was identified by MIC and Kirby Bauer disc diffusion method. The prevalence of aac (6')-Ie-aph (2'')-Ia, aph (3')-IIIa and ant (4')-Ia genes were determined by multiplex- PCR. In total 100 enterococci strains were isolated. The prevalence of E. faecalis and E. faecium isolates were 78% a...
Source: Infectious Disorders Drug Targets - November 29, 2018 Category: Infectious Diseases Authors: Khodabandeh M, Mohammadi M, Abdolsalehi MR, Hasannejad-Bibalan M, Gholami M, Alvandimanesh A, Pournajaf A, Rajabnia R Tags: Infect Disord Drug Targets Source Type: research

Molecular Modeling Studies of Halogenated Imidazoles against 14 α-Demethylase from Candida albicans for treating Fungal Infections.
This study emphasized on evaluation of a series of halogenated imidazole analogues using molecular docking studies for anti-Candidal activity. Furthermore, the model was refined by molecular dynamic simulation. The imidazole analogues were prepared using Chem sketch and molecular docking was performed using Molergo Virtual Docker program and ADMET study was carried out by using Accelry's Accord for Excel programme. The docking study indicated that all the imidazole analogues (PS1-PS30) and standard drugs i.e., Ketoconazole, Miconazole and Clotrimazole possessed interaction with protein residue, heme cofactor and water mole...
Source: Infectious Disorders Drug Targets - November 29, 2018 Category: Infectious Diseases Authors: Rani N, Kumar P, Singh R Tags: Infect Disord Drug Targets Source Type: research

Repurposing of existing drugs for the bacterial infections: An In silico and In vitro study.
CONCLUSION: The parameters such as Microtiter assay: percentage growth retardation and bacterial growth kinetics, Minimum inhibitory concentration (MIC), Post-antibiotic assay and Biofilm formation have indicated the antibacterial potential of metformin, propranolol, and amitriptyline. However, before starting a clinical trial, complete safety and efficacy profile of drugs in the treatment of infectious diseases should be investigated. PMID: 30474540 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - November 25, 2018 Category: Infectious Diseases Authors: Kapoor Y, Sharma R, Kumar A Tags: Infect Disord Drug Targets Source Type: research

The prevalence of bacteriospermia in infertile men and association with semen quality in Southwestern Iran.
Abstract INTRODUCTION: Infertility considered as a social and public health issue and estimated that the most of these infertile couple are residents of developing countries. Infectious diseases including the history of sexually transmitted infections (STIs) may impact on male reproductive function. Therefore, the present study aimed to investigate the prevalence of bacterial contaminants of semen and probable association with sperm quality of infertile men in Iranian population. Methods: The study population consisted of 200 infertile men and 150 fertile men attending to an infertility Center in southwestern Ira...
Source: Infectious Disorders Drug Targets - November 23, 2018 Category: Infectious Diseases Authors: Motamedifar M, Malekzadegan Y, Namdari P, Dehghani B, Jahromi BN, Sarvari J Tags: Infect Disord Drug Targets Source Type: research