Profile of secondary bacterial respiratory infections in H1N1 patients admitted in a tertiary care centre - A four-year retrospective study.
This study aims at analyzing the secondary bacterial infections in confirmed H1N1 cases admitted in our hospital (from 2015 to 2018) with respect to the comorbidities, complications, associated bacteria with its antibiotic susceptibility pattern and the outcome of such episodes. MATERIAL AND METHODS: Data of 164 patients admitted in a tertiary care hospital with H1N1 was extracted from medical records using a semi-structured case report form. Data was entered and analyzed with SPSS version 17. A p value of
Source: Infectious Disorders Drug Targets - January 4, 2021 Category: Infectious Diseases Authors: Khan NK, Shenoy M S, Madi D, Kulkarni V Tags: Infect Disord Drug Targets Source Type: research

Case series and mini review on Elizabethkingia meningoseptica a high alert organism causing meningitis in premature neonates from a tertiary care hospital of Western Rajasthan.
CONCLUSIONS: E. meningoseptica, a high alert organism associated with meningitis among premature underweight neonates. High degree of resistant to most of the broad-spectrum antibiotics makes its management a challenging task. A good communication between the clinician and the microbiologist becomes very important for the proper management of the patients. PMID: 33397245 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - January 4, 2021 Category: Infectious Diseases Authors: Abhishek KS, Kombade SP, Gupta N, Tak V, Nag VL, Singh K, Agarwal N Tags: Infect Disord Drug Targets Source Type: research

SARS-CoV-2: An insight into detection tools.
Abstract The novel coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), was announced as a pandemic in March 2020. Different diagnostic laboratory tests have been used to detect the infection. Each diagnostic tool, such as Chest Computed tomography (CT) imaging, genome sequencing, nucleic acid amplification methods, whole genome sequencing, microarray, and serology testing have several advantages and disadvantages. Nucleic acid amplification methods are better diagnostic tools for the detection of SARS-CoV-2 in early stages of the infection, while serological...
Source: Infectious Disorders Drug Targets - January 4, 2021 Category: Infectious Diseases Authors: Khanmohammadi S, Tabary M, Araghi F, Tavangar SM Tags: Infect Disord Drug Targets Source Type: research

Modifications of Medical Care of Chronic Liver Diseases during COVID19 Pandemic: Necessity or Novelty?
Abstract In the late 2019, coronavirus-2 (SARS-COV 2) infection emerged in Wuhan, China and spread to all countries making the first pandemic in 21st century. It seems that this infection will continue period which is long enough to obligate modifications in both life style and health care systems. Because chronic liver diseases (CLD) are prevalent all over the world, it is expected to manage patients with CLD and COVID-19. The aim of this review was to shade the light on the impact of COVID-19 pandemic on the management of patients with CLD and how to give medical care to CLD patients during COVID-19 pandemic. ...
Source: Infectious Disorders Drug Targets - January 4, 2021 Category: Infectious Diseases Authors: Soliman HH, Emara MH, Elkadeem M, Abd-Elsalam S Tags: Infect Disord Drug Targets Source Type: research

Increased level of interleukin-8 in female genital tract after HP eradication lines.
Abstract The study investigated the levels of cytokines IL-8 and TNF-α in vaginal secretion in a group of female patients with Helicobacter-associated acid-related diseases who were or were not treated with antibiotics against anti-Helicobacter therapy. It turned out that the secretory cytokine (chemokine) IL-8 is dramatically increased in the vaginal mucosa in patients treated with antibiotics, specifically in post-menopause women. Thus, we conclude that helicobacter pylori eradication treatment affects the immune status of the female genital tract. PMID: 33397248 [PubMed - as supplied by publisher] (S...
Source: Infectious Disorders Drug Targets - January 3, 2021 Category: Infectious Diseases Authors: Kravtsov V, Surovtceva T, Taame M, Grukhin Y, Kalinina N Tags: Infect Disord Drug Targets Source Type: research

Health benefits of Buckwheat (Fagopyrum esculentum), potential remedy for diseases, rare to cancer: A mini Review.
Abstract Buckwheat is a gluten-free pseudo-cereal that is a part of the Polygonaceae family. Grain of buckwheat is a highly healthy component of food and has been found to have a broad variety of beneficial effects. It is cultivated as grain in a popular buckwheat (Fagopyrum esculentum) is a secondary significance in many countries. It contains certain high-level nutritionally beneficial components and can have other characteristics as functional food. Buckwheat protein is of outstanding quality and, unlike popular cereals, is rich in critical amino acid lysine. Health benefits of this plants include reducing plas...
Source: Infectious Disorders Drug Targets - December 24, 2020 Category: Infectious Diseases Authors: Noreen S, Rizwan B, Khan M, Farooq S Tags: Infect Disord Drug Targets Source Type: research

Pharmacological strategies for COVID-19 - A review of the most promising repurposed antiviral drugs.
Abstract A novel coronavirus, SARS-CoV-2 (2019-nCoV) emerged in December 2019 as an immediate global challenge. Comprehensive efforts at present time are focused simultaneously on containing spread of this virus and extenuating the ill effects. There is an immediate need for drugs that can help before a vaccine can be developed. Researchers are endeavoring to find antiviral therapies specific to the virus. As the condition is an emerging, rapidly evolving situation and development of new drugs is a long process, and is unfeasible to face the immediate global challenge. Strategy to reposition the previously used dr...
Source: Infectious Disorders Drug Targets - December 18, 2020 Category: Infectious Diseases Authors: Chopra D, Boparai JK, Bhandari B, Srivastava A, Gupta R Tags: Infect Disord Drug Targets Source Type: research

Possible therapeutic interventions in COVID-19 induced ARDS by cotinine as an ACE-2 promoter and AT-1R blocker.
Abstract In these challenging times of the pandemic, as coronavirus disease 2019 (COVID-19) has taken over the planet, its complications such as acute respiratory distress syndrome (ARDS) have the potential to wipe out a large portion of our population. Whereas a serious lack of ventilators, vaccine being months away makes the condition even worse. That's why promising drug therapy is required. One of them was suggested in this article. It is the angiotensin-converting enzyme-2 (ACE-2) to which the COVID-19 virus binds and upon downregulation of which the pulmonary permeability increases and results in the filling...
Source: Infectious Disorders Drug Targets - December 18, 2020 Category: Infectious Diseases Authors: Sharma T, Mehan S Tags: Infect Disord Drug Targets Source Type: research

Evaluation of Salivary Helicobacter pylori, Calcium, Urea, pH and flow rate in Hemodialysis patients.
CONCLUSION: Oral cavity as an important external source of Helicobacter pylori may play an important role in gastrointestinal problems of hemodialysis patients. Helicobacter pylori, Urea, calcium and pH were significantly higher in the patient group .Chronic renal failure can increase pH, urea and calcium in saliva and decrease salivary flow rate. PMID: 33342422 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - December 18, 2020 Category: Infectious Diseases Authors: Teimoori F, Hajilooei M, Abdolsamadi H, Eslami K, Moghimbeigi A, Ahmadi-Motamayel F Tags: Infect Disord Drug Targets Source Type: research

An Updated Review on COVID-19.
Abstract Coronavirus Disease (COVID-19) pandemic has affected more than seven million individuals in 213 countries worldwide with a basic reproduction number ranging from 1.5 to 3.5 and an estimated case fatality rate ranging from 2% to 7%. A substantial proportion of COVID-19 patients are asymptomatic; however, symptomatic cases might present with fever, cough, and dyspnoea or severe symptoms up to acute respiratory distress syndrome. Currently, RNA RT-PCR is the screening tool, while bilateral chest CT is the confirmatory clinical diagnostic test. Several drugs have been repurposed to treat COVID-19, including c...
Source: Infectious Disorders Drug Targets - December 16, 2020 Category: Infectious Diseases Authors: Ebada MA, Allah AW, Bahbah E, Negida A Tags: Infect Disord Drug Targets Source Type: research

Constrictive Pericarditis Associated with Coronavirus Disease 2019 (COVID-19): A Case Report.
Abstract Since December 2019, there has been an increasing number of patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) around the world. As of March 2020, the World Health Organization declared a global pandemic. To our best knowledge, this is the first report of a patient with SARS-CoV-2 infection presenting with constrictive pericarditis, possibly from the COVID infection. She was presented after a week of fever, persistent dry cough, and diarrhea. She received a single dose of hydroxychloroquine 400 mg, Oseltamivir 75 mg every 12 hours, lopinavir/ritonavir (Kaletra) 400/100...
Source: Infectious Disorders Drug Targets - December 9, 2020 Category: Infectious Diseases Authors: SeyedAlinaghi S, Ghadimi M, Gharabaghi MA, Ghiasvand F Tags: Infect Disord Drug Targets Source Type: research

Coronavirus Disease 2019: Virology and Drug Targets.
Abstract The Coronavirus Disease 2019, a pandemic caused by novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is seriously affecting global health and the economy. As the vaccine development takes time, the current research is focused on repurposing FDA approved drugs against the viral target proteins. This review discusses the current understanding of SARS-CoV-2 virology, its target structural proteins (S- glycoprotein), non-structural proteins (3- chymotrypsin-like protease, papain-like protease, RNA-dependent RNA polymerase, and helicase) and accessory proteins, drug discovery strategies (drug...
Source: Infectious Disorders Drug Targets - December 9, 2020 Category: Infectious Diseases Authors: Krishnamurthy PT Tags: Infect Disord Drug Targets Source Type: research

Physiology to Disease Transmission of Respiratory Tract Infection: A Narrative Review.
CONCLUSION: Through this review we conclude that there are various factors that are responsible for the initiation of sneeze and cough but in case of infection it is mainly the inflammatory reaction that directly stimulates the receptors to produce the reflex outburst of air. As the flow of air during expiration is turbulent it causes damage to the Epithelial Lining Fluid present in the respiratory conduit and also gets admixed with the saliva in the oropharynx and oral cavity and mucus in the nose to form droplets of various sizes. Large droplets Settle close and are responsible for Droplet and Fomite transmission but the...
Source: Infectious Disorders Drug Targets - December 9, 2020 Category: Infectious Diseases Authors: Singh NK, Kumar N, Singh AK Tags: Infect Disord Drug Targets Source Type: research

The Prevalence of Shiga toxin-1 in non-Shigella dysenteriae isolates collected from diarrhea samples in patients, Ahvaz, Iran.
CONCLUSION: Isolates of this study were not capable of stx1 encoding. Future investigations should consider the relations between other Shigella species and Shigella toxin in Iran. PMID: 33292146 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - December 7, 2020 Category: Infectious Diseases Authors: Mahdian N, Kouhsari E, Gheysarzadeh A, Maleki A, Valadbeigi H, Sadeghifard N Tags: Infect Disord Drug Targets Source Type: research

Evaluation of the Binding Affinity of Anti-Viral Drugs against Main Protease of SARS-CoV-2 through a Molecular Docking Study.
CONCLUSION: In conclusion, protease inhibitors may be effective potential antiviral agents against Mpro to combat SARSCoV-2. PMID: 33292147 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - December 7, 2020 Category: Infectious Diseases Authors: Mondal M, Sarkar C, Jamaddar S, Khalipha ABR, Islam MT, Mahafzah A, Mubarak MS Tags: Infect Disord Drug Targets Source Type: research

Expression of mir-221, mir-29a, mir-155 and mir-146ain peripheral blood mononuclear cell (PBMC) in HIV-1 infected patients.
Abstract BACKGROUND AND AIM: In patients infected by HIV-1, some cellular biomarkers such as microRNAs have an important function in the suppression or progression of the disease. The aim of the current study is to evaluate the expression of mir-221, mir-29a, mir-155, and mir-146a in HIV-1 infected patients. METHODS: The miRNAs of 60 HIV-1 infected patients (sample group) and 20 healthy controls (normal group) were extracted from their peripheral mononuclear cells. We used TaqMan-based Real-time PCR for evaluation of expression mir-155,mir221, mir-29a and mir-146a by the comparative method. To evaluate differ...
Source: Infectious Disorders Drug Targets - December 7, 2020 Category: Infectious Diseases Authors: Narouei A, Rouzbahani NH, Ghanbari M, Taj L, Mohraz M, Gholami M, Baesi K Tags: Infect Disord Drug Targets Source Type: research

Pulmonary Valve Endocarditis: A Case Report.
Abstract Isolated pulmonary valve endocarditis (PVE) is an extremely uncommon clinical finding comprising less than 1.5-2% of cases for infective endocarditis. It is a challenging condition to diagnose mainly because of nonspecific signs and symptoms at presentation. A 58-year-old married and retired man was admitted to a community hospital for evaluation of chest pain. Transesophageal echocardiography (TEE), 2 days after, revealed semi-mobile vegetation on the pulmonary valve and pulmonary artery wall. Moreover, occlude devices at the root of the aorta, and the pulmonary artery was seen. Left ventricular ejection...
Source: Infectious Disorders Drug Targets - December 3, 2020 Category: Infectious Diseases Authors: Hajiabdolbaghi M, Ahmadieh A, SeyedAlinaghi S, Nezhad MH Tags: Infect Disord Drug Targets Source Type: research

A Review on the Current Principles of Antibiotic Therapy for Diabetic Foot Infection.
Abstract Foot infections being one of the major complications, accounts for nearly 15% of people with diabetes and in-crease their risk for amputation in lower extremities. Though various factors contribute to the development of diabetic foot infection, poor glycemic control poses a greater risk paving way for a number of micro-organisms to colonize the wound. In order to restore the lost granulation tissue at the ulcer site, the prime aim should not only be attaining a glycemic control but also must focus on performing culture by clinically differentiating the stage of infection as well as to manage or control th...
Source: Infectious Disorders Drug Targets - November 26, 2020 Category: Infectious Diseases Authors: Bharathi SP, Sukumaran SK Tags: Infect Disord Drug Targets Source Type: research

COVID-19 Treatment Success After Repeat Courses of Azithromycin: a report of three cases.
We describe three patients diagnosed with COVID-19 who did not respond to the initial treatment but improved dramatically upon adding azithromycin with a successful outcome. PMID: 33243134 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - November 26, 2020 Category: Infectious Diseases Authors: Ghiasvand F, Ghadimi M, Sadr S, Jafari F, Manafi N, Ah-Madinejad Z, Tirgar S, Seyed Alinaghi SA Tags: Infect Disord Drug Targets Source Type: research

Coccidiomycosis immitis Resulting in a Prosthetic Joint Infection in an Immunocompetent Patient after a Total Hip Arthroplasty: A Case Report and Review of the Literature.
Abstract Coccidiomycosis immitis is a fungal infection that is a rare cause of prosthetic joint infection (PJI) in patients. This case report describes an immunocompetent patient who had a right total hip arthroplasty (THA) complicated with Coccidiomycosis immitis. This patient is the 9th reported case of Coccidiomycosis immitis causing a PJI and only the second case to be reported in a THA. Once progressed, it can be difficult to treat, often reoccurring and requiring repeat sur-gical and prolonged therapy. We discuss the clinical presentation in this patient and review the literature on the current pub-lished ca...
Source: Infectious Disorders Drug Targets - November 23, 2020 Category: Infectious Diseases Authors: Shah S, Haq S, Antony SJ Tags: Infect Disord Drug Targets Source Type: research

Fournier's gangrene due to Salmonella Typhimurium in a healthy male: a rare aberrant infection.
CONCLUSION: In our case report, we describe a case of fournier's gangrene due to Salmonella Typhimurium in an otherwise healthy male to highlight the unusual presentation of Non typhoidal salmonellae at an aberrant site. We also emphasize the importance of using selective media like Selenite F broth for isolation of Salmonella Typhimurium from a pus sample. PMID: 33208080 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - November 17, 2020 Category: Infectious Diseases Authors: Gupta V, Singhal L, Pal K, Bhushan M, Sharma R, Chander J Tags: Infect Disord Drug Targets Source Type: research

Iranian herbal medicines against hydatid cyst protoscoleces: A Systematic Review.
CONCLUSION: Considering the high efficacy of Iranian herbal medicines against hydatid cyst protoscoleces, it can be concluded that Iranian herbal medicines have ability to consider as new alternative protoscolicidal agents during hydatid cyst surgery; however, more clinical studies are required to discover the precise protoscolicida activity of Iranian medicines in animal and human subjects. PMID: 33208081 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - November 17, 2020 Category: Infectious Diseases Authors: Salimikia I, Hakami M, Shahmoradi MK Tags: Infect Disord Drug Targets Source Type: research

Prevalence of intestinal parasitic infections among diarrheic patients from Ahvaz, southwestern Iran.
CONCLUSION: This study demonstrated that G. duodenalis was the predominant parasite found among the patients. The re-sults revealed that intestinal parasites were one of the main health problems in the region. PMID: 33200700 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - November 16, 2020 Category: Infectious Diseases Authors: Karami S, Beiromvand M, Kohansal K Tags: Infect Disord Drug Targets Source Type: research

Whole genome analysis of extensively drug-resistant Acinetobacter bau-mannii clinical isolates in Thailand.
CONCLUSIONS: Whole-genome sequencing revealed both blaOXA-23 harboring XDRAB isolates were clustered under interna-tional clone II with difference STs and carrying multiple antimicrobial-resistant genes conferred their resistance to antimi-crobial agents. Inactivation of antimicrobials and target modification by enzymes, and pumping antibiotics by efflux pump are mainly resistance mechanism of the XDRAB in this study. PMID: 33200701 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - November 16, 2020 Category: Infectious Diseases Authors: Chopjitt P, Kerdsin A, Takeuchi D, Hatrongjit R, Boueroy P, Akeda Y, Tomono K, Hamada S Tags: Infect Disord Drug Targets Source Type: research

In vitro and ex vivo antiparasitic effect of Rheum ribes L. extract against the hydatid cyst protoscoleces.
CONCLUSION: The obtained results exhibited the potent protoscolicidal effects of R. ribes extract particularly at the concentration of 900 mg/ml which completely killed the parasite after
Source: Infectious Disorders Drug Targets - November 15, 2020 Category: Infectious Diseases Authors: Mahmoudvand H, Saki M, Kiani AA, Taban T, Shahmoradi MK Tags: Infect Disord Drug Targets Source Type: research

A Patient with COVID-19 Pneumonia Presenting with Plural Effusion: A Case Report.
Abstract In February 2020, coronavirus disease (COVID-19) emerged in Tehran, Iran. Herein, we reported clinical features, laboratory tests, unusual radiological characteristics and therapeutic course of a patient with initial mild clinical symptoms at presentation with progression to pneumonia and pleural effusion in emergency unit of a referral hospital. PMID: 33200715 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - November 15, 2020 Category: Infectious Diseases Authors: Ghiasvand F, SeyedAlinaghi S, Tirgar S, Salehi MR, Moradmand-Badie B Tags: Infect Disord Drug Targets Source Type: research

Transmission Modes of COVID-19: A Systematic Review.
CONCLUSION: Droplet and contact with contaminated surfaces were the most frequent transmission modes of COVID-19. Fecal excretion, environmental contamination, and fluid pollution might contribute to a viral transmission. The possibility of fecal transmission of COVID-19 has implications, especially in areas with poor sanitation and the environmental pollution can be caused by patients with SARS-CoV-2 through respiratory droplets and feces, subsequently, the human environment will change to a potential medium of virus transmission. PMID: 33200716 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - November 15, 2020 Category: Infectious Diseases Authors: Mehraeen E, Salehi MA, Behnezhad F, Moghaddam HR, SeyedAlinaghi S Tags: Infect Disord Drug Targets Source Type: research

Pharmacological inhibition of MMP3 as a potential therapeutic option for COVID-19 associated acute respiratory distress syndrome.
Abstract The high mortality of coronavirus disease 2019 (COVID-19) patients is due to their progression to cytokineassociated organ injuries, primarily the acute respiratory distress syndrome (ARDS). The uncertainties in the molecular mechanisms leading to the switch from the early virus infection to the advanced stage ARDS is a major gridlock in therapeutic development to reduce mortality. Previous studies in our laboratory have identified matrix metalloprotease-3 (MMP3) as an important mediator of bacterial lipopolysaccharide (LPS)-induced ARDS, particularly in the exudative phase. Our studies have also reported...
Source: Infectious Disorders Drug Targets - November 15, 2020 Category: Infectious Diseases Authors: Kadry R, Newsome AS, Somanath PR Tags: Infect Disord Drug Targets Source Type: research

Antibiotic Susceptibility Evaluation of Bacterial Agents Causing Infection in Children with Acute Tonsillopharyngitis.
CONCLUSION: The results showed the higher the clinical score, the greater the chance of positive throat culture. PMID: 33200718 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - November 15, 2020 Category: Infectious Diseases Authors: Sherkatolabbasieh H, Firouzi M, Shafizadeh S, Amiri I Tags: Infect Disord Drug Targets Source Type: research

Detection of antibiotic resistance genes among multiple drug resistant pseudomonas aeruginosa isolated from clinical sources in selected health institutions in kwara state.
CONCLUSION: This study has shown that there is a high occurrence of metallo β-lactamase enzyme producing and antibioticresistant strains of P. aeruginosa in clinical specimens from the studied area. Necessary measures must therefore be implemented to stop the problems of this antibiotic resistance. PMID: 33200719 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - November 15, 2020 Category: Infectious Diseases Authors: Adekunle C, Mustapha A, Odewale G, Richard O Tags: Infect Disord Drug Targets Source Type: research

Multifocal Osteolytic Lesions in Skull Bone with Mycobacterium Tuberculosis: A Case Report.
Abstract Bone Tuberculosis of the skull base as well as maxillofacial and oral cavity involvement can occur rarely and on-ly occur in about 3% of the cases in systemic diseases or in case of pulmonary involvement. A 37-year-old patient with fe-ver and swelling in his face and neck referred to our center. After MRI and CT scan it was revealed that multiple erosions and destructions are seen in the Hard Palate bones, the pre-maxillary process, alveolar ridge, and the floor of maxillary sinus on both sides. In the Ziel Nelson staining, there were 5 bacilli in each field. He received standard anti-tuberculosis and cla...
Source: Infectious Disorders Drug Targets - November 11, 2020 Category: Infectious Diseases Authors: Mellat-Ardakani M, Ghiasvand F, Nezhad MH, Salahshour F, Seyed Alinaghi SA Tags: Infect Disord Drug Targets Source Type: research

Postoperative COVID-19 pneumonia in an asymptomatic patient: a case report.
In this report, we described a case of an elderly female developed with postoperative pulmonary complications after uneventful elective minor surgery. The patient was asymptomatic before the operation with no history of cough or fever. After surgery, the patient developed respiratory distress and chest radiological imaging revealed bilateral ground-glass opacities. It seems any type of surgeries requiring local anesthesia or general anesthesia may contribute to worsening outcomes in patients with covid19. PMID: 33183212 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - November 11, 2020 Category: Infectious Diseases Authors: Asadollahi-Amin A, Shahmohamadi E, Hasibi M, Moosivand M, Taghizadeh M, Seyed Alinaghi SA Tags: Infect Disord Drug Targets Source Type: research

Exploring photoactivated disinfection-induced bystander effects on microbial biofilms of Aggregatibacter actinomycetemcomitans.
Abstract BACKGROUND: Photoactivated disinfection (PAD) has been indicated as one of the potential methods for the initial periodontal therapy in periodontitis and peri-implantitis, which may have the bystander effects on the viability of off-target cells. OBJECTIVE: In this article, we evaluated the effects of PAD-induced bystander on biofilm formation ability, metabolic activity, and gene expression level of Aggregatibacter actinomycetemcomitans as one of the bacteria involved in causing periodontitis and peri-implantitis. METHODS: Bystander effects induced by bacterial cell suspension (BCST ) obtained ...
Source: Infectious Disorders Drug Targets - November 9, 2020 Category: Infectious Diseases Authors: Pourhajibagher M, Bahador A Tags: Infect Disord Drug Targets Source Type: research

An overview on COVID-19 pandemic: from discovery to treatment.
Abstract Recently, novel coronavirus infection (COVID-19) emerged in Wuhan, China has been declared as pandemic by WHO. Until now, no evidence is documented regarding its wild animal reservoir or intermediary host, but, human-to-human transmission, asymptomatic carriers were very much observed. The number of confirmed cases and death toll have been increased almost all over the world indicating its potential threat to public health. Though the phylogenetic analysis shows some similarity of SARS-CoV2 to bat betacoronaviruses, it exhibited significant variation in S1 domain of spike protein from bat-derived viruses....
Source: Infectious Disorders Drug Targets - November 8, 2020 Category: Infectious Diseases Authors: Panati K, Tatireddygari VRA, Narala VR Tags: Infect Disord Drug Targets Source Type: research

An Update to Enterococcal Bacteremia: Epidemiology, Resistance, and Outcome.
This study was a cross-sectional study that investigates all cases of positive blood cultures with Enterococcus spp. at a tertiary referral colligates hospital in Tehran in 2018. RESULTS: Enterococcus spp. was isolated from blood cultures of a total of 73 patients. The most patients were male 42 (57.7%). The mean age of the patients was 58.8 (±18.8) years. Hospital-acquired infection was the most type of infection involving enterococcal bacteremia (80.8%) comparing with community-acquired (6.7%) and health care-associated (12.3%). Renal failure and cancer were the most underlying disease in E. faecalis and E. f...
Source: Infectious Disorders Drug Targets - November 3, 2020 Category: Infectious Diseases Authors: Jafari S, Abdollahi A, Sabahi M, Salehi M, Asadollahi-Amin A, Hasannezhad M, Seifi A Tags: Infect Disord Drug Targets Source Type: research

Comparative analysis of miRNA expressions in different developmental stages of Echinococcus granulosus in mono-phasic and di-phasic culture systems.
CONCLUSION: Differential expression of four miRNAs among different in vitro and ex vivo developmental stages of E. granu-losus was documented in the present study. Further experimental investigations are required to elucidate the probable role of the miRNAs in bi-directional differentiation of protoscoleces either into the strobilated worm or to a secondary hydatid cyst and the potential of these miRNAs as drug targets. PMID: 33155918 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - November 3, 2020 Category: Infectious Diseases Authors: Mortezaei S, Afgar A, Sadeghi B, Mohammadi MA, Mousavi SM, Harandi MF Tags: Infect Disord Drug Targets Source Type: research

Methicillin-Sensitive Staphylococcus Aureus Pyogenic Iliopsoas Abscesses: A case series from Jodhpur, India.
Abstract Early recognition of iliopsoas abscess is important for limiting morbidity and mortality. Mycobacterium tubercu-losis remains an important cause of iliopsoas abscess in developing countries and most patients are initiated on empirical an-ti-tubercular therapy. In this context, methicillin-sensitive Staphylococcus aureus (MSSA) as a cause of iliopsoas abscess is rare in India. Four cases were diagnosed with pyogenic iliopsoas abscesses caused by MSSA. Half of the patients had typi-cal clinical triad of fever, difficulty in walking and backache. Primary iliopsoas abscesses was present in three patients. All...
Source: Infectious Disorders Drug Targets - November 3, 2020 Category: Infectious Diseases Authors: Vijayvergia P, Vijayan N, Midha NK, Kumar D, Gopalakrishnan M, Tiwari S, Garg MK Tags: Infect Disord Drug Targets Source Type: research

Seroprevalence of Hepatitis E Virus infection among pregnant women in Ilam, west of Iran.
CONCLUSION: The seroprevalence rate of HEV infection among pregnant women in Ilam city is relatively low. Considering that seronegative pregnant women is at risk for acquiring HEV, it is recommended that pregnant women be educated to avoid sources of HEV infection. PMID: 33155920 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - November 3, 2020 Category: Infectious Diseases Authors: Kenarkoohi A, Falahi S, Ghelijie F, Mirzaei A Tags: Infect Disord Drug Targets Source Type: research

Molecular characterization of Echinococcus granulosus sensu stricto isolated from livestock of Qazvin, Iran.
CONCLUSION: Our findings confirmed the presence of E. granulosus sensu stricto in the region although further studies are required to determine the haplotype diversity of E. granulosus using different mitochondrial and nuclear genes. PMID: 33121421 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - October 29, 2020 Category: Infectious Diseases Authors: Shahnazi M, Habibvand M, Johkool MG, Hajialilo E, Sharifdini M, Javadi A, Saraei M Tags: Infect Disord Drug Targets Source Type: research

Efficacy of Lopinavir/Ritonavir Compared With Standard Care for Treatment of Coronavirus Disease 2019 (COVID-19): A Systematic Review.
CONCLUSION: There is not yet enough evidence to support the regular use of lopinavir/ritonavir in the treatment of COVID19. Further clinical trials are needed to evaluate lopinavir/ritonavir's efficacy in treatment. PMID: 33121422 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - October 29, 2020 Category: Infectious Diseases Authors: Hariyanto TI, Kristine E, Jillian Hardi C, Kurniawan A Tags: Infect Disord Drug Targets Source Type: research

A Viewpoint On Potential Biomarkers For Infectious COVID-19 severity: An Updated Literature Survey.
PMID: 33076812 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - October 19, 2020 Category: Infectious Diseases Authors: Mali SN, Mohajer F, Ziarani GM, Pratap AP Tags: Infect Disord Drug Targets Source Type: research

Treatment of hepatitis C Cirrhotic patients with directly acting antivirals: A multicenter study.
CONCLUSIONS: sofosbuvir based regimens were effective and safe in the treatment of cirrhotic patients with chronic hepatitis C genotype 4. PMID: 33076813 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - October 19, 2020 Category: Infectious Diseases Authors: Elfert AA, Abd-Elsalam S, Abo-Ali L, Eldemerdash T, AbouSaif S, Elsabagh HM, Ebeid A, Badawi R Tags: Infect Disord Drug Targets Source Type: research

BCG vaccine, a ray of hope in treating Severe Acute Respiratory Syndrome (SARS).
Abstract In December 2019 in Wuhan, China, the Severe Acute Respiratory Syndrome - Corona Virus - 2 (SARS-CoV-2) (also 2019 nCoV) was first discovered. Later WHO declared that SARS-CoV-2 was responsible for Coronavirus Disease 2019 (COVID-19). The round, elliptical or pleomorphic shape of the 2019-nCoV is 60-140 nm in diameter. It comprises a single stranded genome of RNA that comprises 29891 nucleotides, a lipid shell and spike protein, envelops membrane, and hemagglutinin-esterase (HE) proteins. Several therapeutic approaches have been proposed to combat with this disease as this disease became global pandemic. ...
Source: Infectious Disorders Drug Targets - October 16, 2020 Category: Infectious Diseases Authors: Banerjee AB, Singh TG, Prashar A Tags: Infect Disord Drug Targets Source Type: research

COVID-19 And Type 2 Diabetes Mellitus: Hydroxychloroquine May Be The Holy Grail.
Abstract The novel coronavirus disease (COVID-19) is on the rampage claiming over 297000 lives globally. Disease severity and mortality rates are higher in patients with underlying diabetes mellitus. Till date, there exists no effective vaccine or therapy against COVID-19. However, with limited clinical data, hydroxychloroquine is being used for treatment and prophylaxis in patients with COVID-19. Hydroxychloroquine is also used as an anti-diabetic drug and has been approved in India as an adjunct to diet and exercise to improve glycemic control of patients on metformin, sulfonylurea combination in type 2 diabetes...
Source: Infectious Disorders Drug Targets - October 13, 2020 Category: Infectious Diseases Authors: Pal R, Bhasin MK, Bhadada SK Tags: Infect Disord Drug Targets Source Type: research

Covid-19, SARS -CoV-2, Origin, transmission and treatment aspects, a brief review.
Abstract The emergence of severe acute respiratory syndrome (SARS) in Wuhan (china) named as corona virus disease 19(covid-19) caused by the novel corona virus SARS-CoV-2 has caused hundreds of thousands of mortalities across the world ,while the mortality rate is in millions, leading it to be declared as a global pandemic. Numerous research activities are undergoing to reveal the disease and etiological features of covid-19. In this review, some of the interesting aspects of covid-19 are discussed, that includes, the origin of the SARS-CoV-2, clinical manifestation, treatment and future aspects of the disease. ...
Source: Infectious Disorders Drug Targets - October 5, 2020 Category: Infectious Diseases Authors: Nawaz S Tags: Infect Disord Drug Targets Source Type: research

Preparation and characterization of a nanoliposomal vaccine of pcLACK candidate against cutaneous leishmaniasis.
CONCLUSION: Immunostimulatory cationic lipids bearing a pcLACK encapsulation could serve as an effective delivery system. PMID: 33019941 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - October 4, 2020 Category: Infectious Diseases Authors: Hezarjaribi HZ, Soosaraei M, Fakhar M, Akhtari J, Rafiei A, Jorjani ON Tags: Infect Disord Drug Targets Source Type: research

First Detection of Tobacco Mosaic Virus in Tobacco Fields in Northern Lebanon.
CONCLUSION: Our study is the first in Lebanon revealing TMV infection in crop fields, and highlighting the danger that may affect the future of agriculture. PMID: 32988357 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - September 27, 2020 Category: Infectious Diseases Authors: Obeid R, Wehbe E, Rima M, Kabara M, Al Bersaoui R, Sabatier JM, Fajloun Z, Gereige D Tags: Infect Disord Drug Targets Source Type: research

Immuno-Informatics Quest against COVID-19/SARS-COV-2: Determining Putative T-Cell Epitopes for Vaccine Prediction.
CONCLUSION: The study has predicted T-cell epitopes that can elicit robust immune response in global human population and act as potential vaccine candidates. However, the ability of these epitopes to act as vaccine candidate needs to be validated in wet lab studies. PMID: 32957905 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - September 20, 2020 Category: Infectious Diseases Authors: Akhtar N, Joshi A, Singh B, Kaushik V Tags: Infect Disord Drug Targets Source Type: research

Community- and Health Care-Associated Methicillin-Resistant Staphylococcus aureus Infection in Tehran, Iran: Comparison of drug resistance and virulence determinants.
CONCLUSIONS: CA- and HA- MRSA isolates are epidemiologically and microbiologically distinct. Thus, the strategies to prevent and treat these infections would be different. Patients with CA- and HA-MRSA infections should be treated effectively and receive follow-up evaluation to ensure resolution of their infection. Surveillance studies should be conducted to determine the extent of CA- and HA-MRSA dissemination in Iran. PMID: 32957895 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - September 17, 2020 Category: Infectious Diseases Authors: Yadegarynia D, Tehrani S, Nasiri M Tags: Infect Disord Drug Targets Source Type: research

Prevalence of OXA-type class D β-lactamases among clinical isolates of Klebsiella pneumoniae in multiple centers in Tehran, Iran.
CONCLUSIONS: The spread of blaOXAs, especially blaOXA-48-like among K. pneumoniae isolates indicated the inadequate dissemination control of multidrug-resistant bacteria in the Iranian hospital environment. There is reason to assume that OXA producing K. pneumoniae will limit clinical therapeutic options in the future and pose threats to national public health among the Iranian population. PMID: 32942981 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - September 16, 2020 Category: Infectious Diseases Authors: Mehrbakhsh P, Basharkhah Y, Bahkshi A, Kamarposhti LTN, Bolori S Tags: Infect Disord Drug Targets Source Type: research