IL-18 in Blood Serum of Hepatitis C Patients Might be of Predictive Value for Individual Outcomes.
CONCLUSION: According to our study, IL-18 might be a disease marker associated with HCV infection; however, this conclusion requires further investigation. PMID: 32634083 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - July 7, 2020 Category: Infectious Diseases Authors: Asadipour M, Fazeli P, Zohouri M, Bemani P, Mohebbiniya M, Khansalar S, Fattahi MR, Kalantar K Tags: Infect Disord Drug Targets Source Type: research

Comparison of Helicobacter Pylori Detection: it's Association with Leukocytosis and Monocytosis.
CONCLUSION: Based on studies conducted on patients with Helicobacter pylori infection, noninvasive diagnostics methods can be useful in the diagnosis of Helicobacter infections rather than evaluating anti-Helicobacter pylori serum IgM and also increased blood monocytes could be a reliable confirmation for detection. Furthermore, showed monocytosis must be considered as a Helicobacter pylori infection at first step in area with high infected percentage. PMID: 32634084 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - July 7, 2020 Category: Infectious Diseases Authors: Rahimkhani M, Mordadi A, Kazemian K, Khalili H Tags: Infect Disord Drug Targets Source Type: research

Epidemiological Characteristics and Risk Factors of Tinea Pedis Disease Among Adults Attending Tikrit Teaching Hospital/ Iraq.
CONCLUSION: The frequency of tinea pedis disease among the study sample was (7%). There was a significant association between age group and the presence of diabetes mellitus disease and wearing occlusive shoes. PMID: 32634085 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - July 7, 2020 Category: Infectious Diseases Authors: Al-Mahmood A, Al-Sharifi E Tags: Infect Disord Drug Targets Source Type: research

Renal Phosphate Handling in Antiretroviral-na ïve HIV-infected Patients.
Renal Phosphate Handling in Antiretroviral-naïve HIV-infected Patients. Infect Disord Drug Targets. 2020 Jul 07;: Authors: Adedeji TA, Adebisi SA, Adedeji NO, Jeje OA, Owolabi RS Abstract BACKGROUND: Human immunodeficiency virus (HIV) infection impairs renal function, thereby affecting renal phosphate metabolism. OBJECTIVES: We prospectively estimated the prevalence of phosphate abnormalities (mild, moderate to life-threatening hypophosphataemia, and hyperphosphataemia) before initiating antiretroviral therapy (ART). METHODS: A cross-sectional analysis was performed on 170 consecutive n...
Source: Infectious Disorders Drug Targets - July 7, 2020 Category: Infectious Diseases Authors: Adedeji TA, Adebisi SA, Adedeji NO, Jeje OA, Owolabi RS Tags: Infect Disord Drug Targets Source Type: research

Bone Marrow Aspiration/Biopsy in the Evaluation of Fever of Unknown Origin in Patients with AIDS.
CONCLUSION: Hypocellular bone marrow was the most common pathology on BMA/B examinations, followed by the presence of granulomas. Tuberculosis, Aspergillosis, and Leishmaniasis were the opportunistic infections diagnosed on BMA/B specimens. Our results support BMA/B as an appropriate diagnostic tool for early diagnosis of opportunistic infections and malignancies in AIDS. BMA/B is indispensable in the armament of diagnostic tools of the physicians managing AIDS patients. PMID: 32628601 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - July 5, 2020 Category: Infectious Diseases Authors: Hajiabdolbaghi M, Ataeinia B, Ghadimi F, SeyedAlinaghi S, Badie BM, Dadras O, Rasoolinejad M Tags: Infect Disord Drug Targets Source Type: research

Mechanistic insights into the anticandidal action of Vanillin reveal disruption of cell surface integrity and mitochondrial functioning.
CONCLUSION: Together, our results suggested that Van is promising antifungal agent that may be advocated for further investigation in therapeutic strategies to treat Candida infections. PMID: 32614756 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - July 2, 2020 Category: Infectious Diseases Authors: Saibabu V, Fatima Z, Khan LA, Hameed S Tags: Infect Disord Drug Targets Source Type: research

The comparison of Real-time-PCR-HRM and Microscopy Methods for Detection of Mixed Plasmodium spp. Infections in Laghman Province, Afghanistan.
CONCLUSIONS: Our result indicated that, the Real-time PCR-HRM method is more accurate and more reliable than microscopic method in the diagnosis of malaria mixed infections. PMID: 32614757 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - July 2, 2020 Category: Infectious Diseases Authors: Dalimi A, Mosawi SH Tags: Infect Disord Drug Targets Source Type: research

In Vitro Effect of Chlorquine and Picroliv on Plasmodium Berghei Induced Alterations in the Activity of Adenosine Triphosphatase, Aryl Hyrocarbon Hydroxylase Enzymes and Malondialdehyde in spleen Explant Culture.
CONCLUSION: Alkalinephosphatase (ALP) was found to increase with increasing parasitaemia. After the addition of Picroliv to the medium, a decrement in the activity was observed up to day 4 of culture.A similar positive effect of Picroliv was observed on the ATPase and ALP activity of spleen explants.DNA and protein contents also increased in the parasitized liver cultured in the presence of picroliv.On the contrary, in the spleen explants DNA, protein and MDA content were found to decrease after Picroliv supplementation to the culture medium. PMID: 32603287 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - June 30, 2020 Category: Infectious Diseases Authors: Trivedi A, Misra A, Sarkar E, Balapure AK Tags: Infect Disord Drug Targets Source Type: research

Miracles of Herbal Phytomedicines in Treatment of Skin Disorders: Natural Healthcare Perspective.
Abstract Human skin considered as the first line of defense and barrier against the majority of infections caused through the skin that are affecting human populations. Healthy skin, promotes healthy body that can achieve with the usage of modern, allopathic and natural remedies. Major skin ailments affecting human populations are skin cancers, eczema, herpes infection, fungal infection, anti-aging, itching, insect bites, pemphigus vulgaris, trauma, psoriasis, athlete's foot infections, rashes, skin pigmentation, acne, major and minor wound infections that are slowly becoming a burden on health care. Skin infectio...
Source: Infectious Disorders Drug Targets - June 22, 2020 Category: Infectious Diseases Authors: Ahuja A, Gupta J, Gupta R Tags: Infect Disord Drug Targets Source Type: research

Mining the Proteome of Streptococcus mutans for Putative Drug Targets.
CONCLUSION: This study will effectuate the development of novel therapeutic agents against dental carries and other Streptococcal infections. PMID: 32568025 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - June 22, 2020 Category: Infectious Diseases Authors: Marimuthu SCV, Ravinarayanan H, Rosy JC, Sundar K Tags: Infect Disord Drug Targets Source Type: research

Targeting infectious Coronavirus Disease 2019 (COVID-19) with Artificial Intelligence (AI) applications: Evidence based opinion.
Abstract The current COVID-19 pandemic has opened the new doors for AI based technology adoption in various health care sectors. This will be bringing opportunities as well as risks. These technologies, upon proper human interventions and directions, will be useful for making faster decisions in current crisis. However, this should not mean that AI could bypass the various regulatory processes. Besides multiple potential applications, we should know that these technologies will be only benefited with proper human interventions and un-biased data. With proper AI based approaches, we will be definitely benefited wit...
Source: Infectious Disorders Drug Targets - June 22, 2020 Category: Infectious Diseases Authors: Mali SN, Pratap AP Tags: Infect Disord Drug Targets Source Type: research

Association between Toxoplasma gondii infection and headache: a systematic review and meta-analysis.
CONCLUSION: The obtained results of several studies have linked toxoplasmosis and headache. Therefore, more quality studies with larger sample sizes are needed to determine the detailed association between headache and T. gondii infection for the prevention and control of toxoplasmosis among headache sufferers. PMID: 32552646 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - June 17, 2020 Category: Infectious Diseases Authors: Nayeri T, Sarvi S, Moosazadeh M, Hosseininejad Z, Amouei A, Daryani A Tags: Infect Disord Drug Targets Source Type: research

Microbiological detoxification of mycotoxins: Focus on Mechanisms and Advances.
Abstract Some fungal species of the genera Aspergillus, Penicillium, and Fusarium secretes toxic metabolites known as mycotoxins, has become a global concern that is toxic to different species of animals and humans. Biological mycotoxins detoxification has been studied by researchers around the world as a new strategy for the mycotoxin removal. Bacteria, fungi, yeast, molds, and protozoa are the main living organisms appropriate for the mycotoxin detoxification. Enzymatic and degradation sorption are the main mechanisms involved in microbiological detoxification of mycotoxins. Regardless of the method used, proper...
Source: Infectious Disorders Drug Targets - June 16, 2020 Category: Infectious Diseases Authors: Abdi M, Asadi A, Maleki F, Kouhsari E, Fattahi A, Ohadi E, Lotfali E, Ahmadi A, Ghafouri Z Tags: Infect Disord Drug Targets Source Type: research

Antimicrobial Activities of Satureja khuzestanica Jamzad; A Review.
Abstract Satureja khuzestanica Jamzad. is a species native to Iran, highly important in Southwestern regions. It belongs to the Lamiaceae family and grows in different climates. A number of pharmacological properties such as analgesic, anti-inflammatory, anticancer, anti-thyroid, antioxidant, and diuretic heve been attributed to this plant. In recent years, a wide range of biological properties, extract, and essential oil of Satureja khuzestanica has been studied by researchers. In the present study, Scopus, SID, ISI, Google Scholar, and PubMed indices were used to extract research articles. No publication time co...
Source: Infectious Disorders Drug Targets - June 10, 2020 Category: Infectious Diseases Authors: Mahmoudvand H, Ezatpour B, Masoori L, Marzban A, Moghaddam A, Shahzamani K, Malekara V, Cheraghipour K Tags: Infect Disord Drug Targets Source Type: research

Characterization of Bacteriological Isolates from Patients and Environment Samples of Burn Ward: A Study from a Tertiary Care Hospital of India.
CONCLUSIONS: In this study, there appears that the colonizers of the environment may play a role in causationof infection in burn patients.In burns ward, rigorous implementation of infection control program should be warranted, which includes and hygiene and use of personal protective equipment, environmental disinfection, cohort nursing care and antibiotics stewardship programme. PMID: 32516105 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - June 9, 2020 Category: Infectious Diseases Authors: Sharma S, Datta P, Gupta V, Kumari P, Kaur G, Chander J Tags: Infect Disord Drug Targets Source Type: research

Screening of Cystic Echinococcosis and Toxocariasis in Urmia Municipal Workers, Northwest Iran.
CONCLUSION: Due to the occupational condition of municipal workers, they're exposed to many infectious agents; thus, more researches should be done on these populations. PMID: 32516106 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - June 9, 2020 Category: Infectious Diseases Authors: Asadi N, Tappeh KH, Mohebi I, Yousefi E, Khademvatan S Tags: Infect Disord Drug Targets Source Type: research

Pleural Effusion as a Sign of Coronavirus Disease 2019 (COVID-19) Pneumonia: A Case Report.
CONCLUSION: Currently, it is important to bear in mind the COVID-19 infection in evaluating the patients with respiratory symptoms. This report indicated how misleading the presentation of chest CT scan could be in clinical judgment. Therefore, we recommend ruling out the COVID-19 infection in all the patients with any pattern of lung involvement to avoid missing the potential cases of this vicious infection. PMID: 32516107 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - June 9, 2020 Category: Infectious Diseases Authors: Ahmadinejad Z, Salahshour F, Dadras O, Rezaei H, Alinaghi S Tags: Infect Disord Drug Targets Source Type: research

High Parasitic Contamination of Soil Samples in the North of Iran: a Potential Risk of Parasitic Infection for Tourists.
Abstract BACKGROUND: Soil-transmitted parasites (STPs) are significant intestinal parasites that infect humans and animals and impose considerable burdens on human society and animal husbandry industries. Therefore, the present study aimed to determine the prevalence of parasitic elements of soil samples collected from the north of Iran. METHODS: A total of 256 soil samples were collected from public parks, public places, vegetable gardens, sand heaps, and shadow areas near houses in the north of Iran and examined using the sucrose flotation method. RESULTS: Out of 256 examined samples, 131 (51.2%) ones ...
Source: Infectious Disorders Drug Targets - June 2, 2020 Category: Infectious Diseases Authors: Haghparast-Kenari B, Nayeri T, Sarvi S, Rahimi MT, Ahmadpour E, Sharif M, Daryani A Tags: Infect Disord Drug Targets Source Type: research

Prevalence of Cutaneous Leishmaniasis in Iran (2000-2016): A Systematic Review and Meta-analysis Study.
In conclusion, CL is an endemic disease in Iran, and its prevalence is largely affected by geographical locations and regional customs. Appropriate preventing measures should be considered to decrease the incidence of CL in Iran. PMID: 32479248 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - June 1, 2020 Category: Infectious Diseases Authors: Panahi S, Abbasi M, Sayehmiri K, Safaripour S, Abdi J Tags: Infect Disord Drug Targets Source Type: research

Disseminated TB in an Immunocompetent Patient: A Case Report.
We reported a54-year-old man with a complaint prolonged fever, abdominal pain, weight loss and lymphadenopathy without any immunosuppression who was eventually treated based on the diagnosis of diffuse tuberculosis. PMID: 32484114 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - May 28, 2020 Category: Infectious Diseases Authors: Nezhad MH, Ganadan A, Alinaghi SAS, Abadi FNA, Manshadi SAD, Salehi MR, Ghiasvand F, Khatami SR Tags: Infect Disord Drug Targets Source Type: research

Evaluation of type II toxin-antitoxin systems, antibiotic resistance profiles, and biofilm quorum sensing genes in Acinetobacter baumannii isolates in Iraq.
CONCLUSION: A high MDR and imipenem resistance rates within a low prevalence of rhlIR, and lasIR genes could be found in clinical A. baumannii isolates from some of Iraqi hospitals. PMID: 32484105 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - May 25, 2020 Category: Infectious Diseases Authors: Al Marjania MF, Kouhsari E, Ali FS, Authman SH Tags: Infect Disord Drug Targets Source Type: research

A Systematic Literature Review of Curcumin With Promising Antileishmanial Activity.
CONCLUSIONS: This review indicated that CUR derivatives instead of alone CUR showed a high potential to serve as an effective herbal drug against leishmaniasis. Moreover, we concluded that the antileishmanial activity of CUR/bioactive compounds is mostly due to increasing oxidative stress and inducing apoptosis. PMID: 32448108 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - May 24, 2020 Category: Infectious Diseases Authors: Saberi R, Fakhar M, Asfaram S, Akhtari J, Nakhaei M, Keighobadi M Tags: Infect Disord Drug Targets Source Type: research

Chronic Suppurative Otitis Media: A Case Report.
CONCLUSION: Usually topical antibiotics, especially ciprofloxacin, is effective against ear infections but our case was different and the P. aeruginosa isolated from CSOM was resistant to most of the antibiotics. One reason for CSOM recurrence might be surgery failure. The routine and primary treatment for CSOM did not seem sufficient and tympanomastoidectomy is suggested to be the best treatment approach for these patients. PMID: 32423374 [PubMed - in process] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - May 21, 2020 Category: Infectious Diseases Authors: Yazdi MMK, Ghalavand Z, Yazdi AK, Kodori M, Taheri M, Tabriz MS, Eslami G Tags: Infect Disord Drug Targets Source Type: research

Study of Plasmid Mediated Quinolone Resistance in Escherichia coli from Nosocomial Urinary Infections.
CONCLUSION: The study highlights the prevalence of PMQR genes in E. coli with high association with ESBL phenotype. This finding is a sign of limited therapeutic options for E. coli. PMID: 32433009 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - May 20, 2020 Category: Infectious Diseases Authors: Zaki MES, El Salam MA, Faried OA Tags: Infect Disord Drug Targets Source Type: research

SARS-CoV-2: The Path of Prevention and Control.
Abstract The 2019 coronavirus pandemic (COVID-19) continues to expand worldwide. Although the number of cases and the death rate among children and adolescents are reported to be low compared to adults, limited data have been reported. We urgently need to find treatment and vaccine to stop the epidemic. Vaccine development is in progress, but any approved and effective vaccine for COVID-19 is at least 12 to 18 months. The World Health Organization (WHO), the Center for Disease Control and Prevention (CDC), and the Food and Agriculture Organization (FAO) have issued instructions and strategies for containing COVID-...
Source: Infectious Disorders Drug Targets - May 20, 2020 Category: Infectious Diseases Authors: Mohamed AA, Mohamed N, Mohamoud S, Zahran FE, Khattab RA, El-Damasy DA, Alsayed E, Abd-Elsalam S Tags: Infect Disord Drug Targets Source Type: research

Counter-regulatory 'Renin-Angiotensin' System-based Candidate Drugs to Treat COVID-19 Diseases in SARS-CoV-2-infected patients.
Abstract SARS-CoV-2 / COVID-19 and the 'Renin-Angiotensin' System The ubiquitous 'Renin-Angiotensin' system (RAS), also referred to as 'Renin-Angiotensin-Aldosterone' system, plays a crucial physiological role in humans as being a key regulator of renal, cardiovascular and innate immune functions [1, 2]. It appears to work in tandem with vitamin D, a secosteroid pro-hormone which reportedly acts as a negative regulatory factor of the RAS [3-6]. A dysfunction (e.g. over-reactivity) of RAS, together with hypovitaminosis D, is likely associated with some of the various renal, cardiac, vascular and immune outcomes tha...
Source: Infectious Disorders Drug Targets - May 17, 2020 Category: Infectious Diseases Authors: Annweiler C, Cao Z, Wu Y, Faucon E, Mouhat S, Kovacic H, Sabatier JM Tags: Infect Disord Drug Targets Source Type: research

Evaluation of Clinical Profile, Diagnostic Tests, And Prognosis of Cryptococcal Meningitis in HIV Infected Patients in Western India.
CONCLUSION: Cryptococcal meningitis is a potentially lethal infection in immunocompromised individuals and should be diagnosed early with high clinical suspicion as around 10% of the cases may not be detected on India ink staining and a large proportion (75%) of cases may have normal imaging at initial evaluation. Early diagnosis, watchful eye on prognostic factors and treatment is vital to improve outcome in these patients. PMID: 32416706 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - May 16, 2020 Category: Infectious Diseases Authors: Kumar D, Bishnoi S, Meena DS, Bohra GK, Midha N, Chhabra V, Bhambu SK Tags: Infect Disord Drug Targets Source Type: research

Evaluation of Glutathione Bioactivity on Toxoplasma Gondii in BALB/c Mice Post Impact of Selenium and Calcium Supplementation.
Abstract Studies have shown that selenium is an essential component of glutathione as an important antioxidant to reduce oxidative stress and inhibit intracellular parasites' growth. In contrast, calcium in cytosol of such parasites plays a key role in entry of the parasite into the host cell and its primary motility. The present study was designed to evaluate and compare glutathione peroxidase bioactivity effects post administration of selenium and calcium in BALB/c mice infected by Toxoplasma gondii (Table 3) Sixty BALB/c mice susceptible to T. gondii were randomly divided into twelve groups of case and control ...
Source: Infectious Disorders Drug Targets - May 16, 2020 Category: Infectious Diseases Authors: Namazi MJ, Nikpour S, Rahimi-Moghaddam P, Hosseini SA, Siyadatpanah A, Mostafavi NSS, Golmohammadi R, Tabatabaie F Tags: Infect Disord Drug Targets Source Type: research

Nocardia Infections: Ten Years Experience from a Tertiary Health Care Center in North India (2007-2016).
CONCLUSIONS: Good communication with the clinician alongside a meticulous effort in the laboratory is essential for appropriate diagnosis and management of these cases. PMID: 32416708 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - May 16, 2020 Category: Infectious Diseases Authors: Bansal Y, Singla N, Butta H, Aggarwal D, Gulati N, Chander J Tags: Infect Disord Drug Targets Source Type: research

Sero-epidemiology of Hydatidosis Among General Population of Jolfa County, Northwestern Iran Using IHA, ELISA and Western Blot (2017-2018).
Abstract BACKGROUND: Human hydatidosis is mostly a latent and neglected disease with known endemicity in Iran. AIMS: Due to the importance of this infection in the country and its latent nature, we aimed to evaluate the serological status of hydatid cyst in northwestern Iran. OBJECTIVES: Herein, we evaluated the serological status of hydatid cyst in urban and rural inhabitants of Jolfa county, northwestern Iran during 2017-2018. METHODS: Totally, 1296 blood samples were obtained from human individuals and the presence of anti-E. granulosus antibodies were investigated using IHA, ELISA and WB. R...
Source: Infectious Disorders Drug Targets - May 16, 2020 Category: Infectious Diseases Authors: Sakhaei G, Khademvatan S, HazratiTappeh K, Masudi S, Feizollahzadeh S, Aminpour A, Asadi N Tags: Infect Disord Drug Targets Source Type: research

Promising in vitro Anti-Toxoplasma gondii effects of commercial Chitosan.
Abstract BACKGROUND: Toxoplasmosis is a disease that results from infection with an obligate intracellular T. gondii parasite, one of the world's most common parasites. Considering the complications of chemical drugs and the need for an appropriate drug combination for treatment of toxoplasmosis and also considering the antimicrobial potential of chitosan, as a natural source, this study was aimed to evaluate in vitro activity of commercial chitosan (CC) on T. gondii. METHODS: In this experimental study, the tachyzoites of T. gondii was collected from the peritoneal exudates from infected Balb/c mice. The tac...
Source: Infectious Disorders Drug Targets - May 10, 2020 Category: Infectious Diseases Authors: Esboei BR, Keighobadi M, Hezarjaribi HZ, Fakhar M, Daryani A, Chabra A, Soosaraei M, Yalveh R Tags: Infect Disord Drug Targets Source Type: research

First Report on the Characteristics of Methicillin Resistant Staphylococcus Capitis Isolates and a NRCS-A-clone Related Isolate Obtained from Iranian Children.
CONCLUSION: According to the studied features, only one isolate belonged to the NRSC-A clone. The results indicate that MRSC with high antibiotic resistance and unknown SCCmec might become a serious problem in the future for the treatment of patients particularly children. PMID: 32389116 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - May 10, 2020 Category: Infectious Diseases Authors: Asadolahi P, Farzan B, Rezaei F, Delfani S, Ashrafi B, Soroush S Tags: Infect Disord Drug Targets Source Type: research

A Viewpoint on Angiotensin-Converting Enzyme 2, Anti-Hypertensives and Coronavirus Disease 2019 (COVID-19).
CONCLUSION In this regards, more laboratory and clinical evidences are required in order to decide COVID-19 treatment. In conclusion to this debate, suggesting roles of antihypertensive agents and severity leading changes in ACE2 levels, may shed more light on infectivity and outcome of COVID-19.There is an urgent need to establish whether treatments with antihypertensive (ACEI's/ ARBs) needs to be determined. PMID: 32389117 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - May 10, 2020 Category: Infectious Diseases Authors: Mali SN, Thorat BR, Chopade AR Tags: Infect Disord Drug Targets Source Type: research

SARS-CoV-2 & Covid-19: Key-Roles of the 'Renin-Angiotensin' System / Vitamin D Impacting Drug and Vaccine Developments.
SARS-CoV-2 & Covid-19: Key-Roles of the 'Renin-Angiotensin' System / Vitamin D Impacting Drug and Vaccine Developments. Infect Disord Drug Targets. 2020 May 05;: Authors: Cao Z, Wu Y, Faucon E, Sabatier JM PMID: 32370727 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - May 5, 2020 Category: Infectious Diseases Authors: Cao Z, Wu Y, Faucon E, Sabatier JM Tags: Infect Disord Drug Targets Source Type: research

Serum Cortisol, Hepcidin and Thyroid Hormone Levels in Neonates with Late Onset ‎Sepsis; Methodological Issues on Diagnostic and Prognostic Studies.
Serum Cortisol, Hepcidin and Thyroid Hormone Levels in Neonates with Late Onset ‎Sepsis; Methodological Issues on Diagnostic and Prognostic Studies. Infect Disord Drug Targets. 2020 May 05;: Authors: Sabour S Abstract I was interested in reading the paper by Hagag A and colleagues that was published in the March 2020 edition of the Infect Disord Drug Targets [1]. Neonatal sepsis is a clinical syndrome characterized by symptoms and signs of infection in the first twenty-eight days of life. Serum thyroid, cortisol and hepcidin are affected by neonatal sepsis. The purpose of the authors was to assess...
Source: Infectious Disorders Drug Targets - May 5, 2020 Category: Infectious Diseases Authors: Sabour S Tags: Infect Disord Drug Targets Source Type: research

A Patient with COVID-19 Disease in a Referral Hospital in Iran: A Typical Case.
We presented a 61-year-old woman with a history of diabetes mellitus was referred to the emergency department of a referral hospital in Tehran, Iran. The patient presented with fever, chills, and myalgia within three days. Laboratory analysis showed increased levels of erythrocyte sedimentation rate (ESR), and mild leukopenia. SARSCoV-2 PCR test -under Iran Ministry of Health and Medical Education (MoH&ME) guidelines - result was positive and the chest X-ray shows bilateral ground glass opacity. O2 saturation was 87% (without O2 therapy). The patient was hospitalized and treated with Oseltamivir 75 mg every 12 hours, L...
Source: Infectious Disorders Drug Targets - April 29, 2020 Category: Infectious Diseases Authors: Ghiasvand F, Miandoab SZ, Harandi H, Golestan FS, Alinaghi SAS Tags: Infect Disord Drug Targets Source Type: research

T9-T10 Osteomyelitis, Epidural Abscess and Cord Compression Secondary to Mycobacterium abscessus. A Case Report.
CONCLUSION: This paper presents a new case of spinal osteomyelitis without a primary source in addition to 10 previously reported M. abscessus cases. The treatment plans and outcomes suggest that surgical debridement along with a macrolide-based combination therapy should be considered a definitive treatment against Mycobacterium abscesses. PMID: 32342821 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - April 27, 2020 Category: Infectious Diseases Authors: Davis MA, Antony S Tags: Infect Disord Drug Targets Source Type: research

Prevalence of Intestinal Parasites among Patients with Chronic Urticaria in Northern Iran.
CONCLUSION: The prevalence of various parasites between case and control groups was not significant. PMID: 32342822 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - April 27, 2020 Category: Infectious Diseases Authors: Mahdi F, Javad G, Abbas D, Jamshid YC, Bahman G, Bahman RE Tags: Infect Disord Drug Targets Source Type: research

Brucella Pneumonia with Systemic Complications and Pancytopenia: A Case Report.
Abstract Iran which is regarded as an endemic region for brucellosis ranked second in brucella prevalence in the world. Pulmonary involvement is a rare complication of brucellosis. In this article, we aimed to report a case of systemic brucellosis complicated with brucella pneumonia. A 39-yearsold man was referred to the emergency department with weakness, productive coughs and severe weight loss during 8 months. Agglutination tests for brucellosis showed high titers suggestive for brucella infection. After 6 days of treatment, the patient clinical state has improved significantly. The patient had systemic signs a...
Source: Infectious Disorders Drug Targets - April 22, 2020 Category: Infectious Diseases Authors: Seyedpour S, Khodaei B, Nezhad MH, Seyed Alinaghi SA, Ghiasvand F Tags: Infect Disord Drug Targets Source Type: research

Evaluation of the effects of Rumex obtusifolius seed and leaf extracts against Acanthamoeba: An in vitro study.
CONCLUSION: These extracts are not promising candidates for further medicine development on acanthamoebiasis. Nonetheless, further researches are necessary to clarify effective fractions of seed and leaf extracts of R. obtusifolius and their mechanisms of action. PMID: 32321413 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - April 22, 2020 Category: Infectious Diseases Authors: Nayeri T, Bineshian F, Khoshzaban F, Asl AD, Ghaffarifar F Tags: Infect Disord Drug Targets Source Type: research

A systematic review and meta-analysis of serotype distribution of Streptococcus pneumoniae in Iran: Practical evidences to optimizing local vaccination protocols.
Abstract BACKGROUND: Little is known regarding the burden of predominant circulating serotypes of Streptococcus pneumoniae in Iran. Therefore, this study aimed to investigate the serotype distribution of pneumococcal diseases in Iran by using a comprehensive systematic review of available articles. METHODS: A systematic literature search carried out to identify papers published by Iranian authors in the Web of Science, PubMed, Scopus, Embase and Google Scholar electronic databases since January of 2000 to December of 2018. Then, eight publications which met our inclusion criteria were selected for data extrac...
Source: Infectious Disorders Drug Targets - April 19, 2020 Category: Infectious Diseases Authors: Karimi A, Hoseini-Alfatemi SM, Tabatabaei SR Tags: Infect Disord Drug Targets Source Type: research

Antibiogram of Urinary Enterococcus isolates from a tertiary care hospital.
CONCLUSION: Isolation of high level aminoglycoside resistant (HLAR) Enterococci is a challenge for the treating physician because aminoglycoside cannot be used in combination with glycopeptide or ampicillin for such isolates. The occurrence of HLAR, Van A and Van B VRE genotypes is a cause of concern as they may transfer drug resistance genes to other bacterial isolates, thus leading to limited therapeutic options. PMID: 32242789 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - April 3, 2020 Category: Infectious Diseases Authors: Bhat NR, Shivashankar SBK, Dhanashree B Tags: Infect Disord Drug Targets Source Type: research

Ralstonia mannitolilytica, an unusual pathogen in the Neonatal Intensive Care Unit: a case of neonatal sepsis and literature review.
CONCLUSION: We intend to raise awareness among neonatologists with regards to early detection of unusual pathogens, emergence of antibiotic resistance patterns, and obligation for adherence to infection control policies. PMID: 32223739 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - March 30, 2020 Category: Infectious Diseases Authors: Lampropoulos P, Gkentzi D, Tzifas S, Kapnisi G, Karatza A, Kolonitsiou F, Dimitriou G Tags: Infect Disord Drug Targets Source Type: research

Diagnostic value of assessment of Serum Cortisol, Hepcidin and Thyroid Hormone Levels in Neonates with Late Onset Sepsis.
CONCLUSION AND RECOMMENDATIONS: Neonates with high probable sepsis had significantly higher serum cortisol and hepcidin and significantly lower free TT3 and free TT4 compared with healthy neonates. These findings may arouse our attention about the use of these markers in diagnosis of in neonatal sepsis which can lead to early treatment and subsequently better prognosis. PMID: 32216741 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - March 27, 2020 Category: Infectious Diseases Authors: Hagag A, Elfarargy MS, Lyonis R, Al-Ashmawy GM Tags: Infect Disord Drug Targets Source Type: research

Bacteriological Profile and Antibiotic Resistance in patients with Urinary tract infection in Tertiary care teaching Hospital in western Rajasthan India.
CONCLUSIONS: The present study gives an idea about the common trend of antibiotic resistance of uropathogens in this region. The findings in our study will help in the formulation of antibiotic policy and determination of empirical treatment of UTI in this region. PMID: 32188395 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - March 18, 2020 Category: Infectious Diseases Authors: Meena M, Kishoria N, Meena DS, Sonwal VS Tags: Infect Disord Drug Targets Source Type: research

Simultaneous detection of drug-resistant mutations in Mycobacterium tuberculosis and determining their role through in silico docking.
CONCLUSIONS: DNA sequencing-based drug resistance detection of TB is more accurate than MAS-PCR. Understanding the role of mutations in influencing the drug-protein interaction will help in designing effective drug alternatives. PMID: 32188396 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - March 18, 2020 Category: Infectious Diseases Authors: Nachappa S, Neelambike S, Sarikhani A, Ramachandra N Tags: Infect Disord Drug Targets Source Type: research

Successful Control of a Co-Infection Caused by Candida albicans and Pseudomonas aeruginosa in Keratitis.
CONCLUSION: Cases of co-infection by Candida and Pseudomonas are not abundantly reported and difficult to treat. In this case, treatment involved Amphotercin-B and ciprofloxacin, effectively eradicated the infection. This therapy may be successfully implied for such cases of co-infection in future. PMID: 32188397 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - March 18, 2020 Category: Infectious Diseases Authors: Paul D, Saha S, Singh N, Sengupta J, Mandal SM Tags: Infect Disord Drug Targets Source Type: research

Differential gene expression of ASUN, NEMF, PTPRC and DHX29: Candidate biomarkers for diagnosis of active and latent tuberculosis.
CONCLUSION: Expression of these four host genes can accurately differentiate between active TB/LTBI cases and healthy individuals as well as between LTBI and active TB patients. However, our findings deserve further validation in larger studies. PMID: 32167431 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - March 13, 2020 Category: Infectious Diseases Authors: Mamishi S, Pourakbari B, Sadeghi RH, Marjani M, Mahmoudi S Tags: Infect Disord Drug Targets Source Type: research

Monoclonal antibodies against infectious microbes: so long and too little!
Abstract Monoclonal antibodies (mAbs) as alternatives or more often as complementary to the conventional antimicrobials are being developed for the management of infectious conditions for the past two decades. These pharmacotherapeutic strategies are inevitable as the burden of antimicrobial resistance is far-reaching in recent times. MAbs are part of the targeted pharmacotherapy armamentarium with high degree of specificity - hence, exert comparatively superior efficacy and tolerability than the conventional polyclonal antisera. So far, only five mAbs have been approved for the management of infectious states - s...
Source: Infectious Disorders Drug Targets - March 12, 2020 Category: Infectious Diseases Authors: Raj G, Priyadarshini R, Murugesan S, Adhimoolam M Tags: Infect Disord Drug Targets Source Type: research

Concurrent Methicillin-resistant Staphylococcus aureus septicemia and thyroid abscess in a young male with Dengue.
CONCLUSION: High anticipation and vigilance is required to detect concurrent bacteremia in dengue patients. Early recognition of warning signs with readily antibiotic therapy is important to prevent mortality and morbidity in these patients. Our report also highlights the MRSA as a rare cause of thyroid abscess with only 5 cases have been reported in the literature so far. PMID: 32164519 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - March 12, 2020 Category: Infectious Diseases Authors: Meena DS, Kumar D, Bohra GK, Garg MK, Midha N, Yadav T, Yadav P Tags: Infect Disord Drug Targets Source Type: research