Different Strategies Targeting Gut Microbiota for the Management of Several Disorders: A Sustainable Approach
CONCLUSION: Although considerable steps in enhancing and understanding the mechanism of treatment with the help of gut microbiota are under progress, much diversified and elaborate research must be conducted in order to enhance and implement the use of GM with high effectiveness.PMID:38317473 | DOI:10.2174/0118715265267536231121095634 (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - February 6, 2024 Category: Infectious Diseases Authors: Mahima Chowdhury Neil Raj Chaudhary Paranjeet Kaur Anju Goyal Sanjeev Kumar Sahu Source Type: research
Insight into the Natural Biomolecules (BMs): Promising Candidates as Zika Virus Inhibitors
Infect Disord Drug Targets. 2024 Feb 2. doi: 10.2174/0118715265272414231226092146. Online ahead of print.ABSTRACTZika virus (ZIKV) is among the relatively new infectious disease threats that include SARS-CoV2, coronavirus, monkeypox (Mpox) virus, etc. ZIKV has been reported to cause severe health risks to the fetus. To date, satisfactory treatment is still not available for the treatment of ZIKV infection. This review examines the last five years of work using natural biomolecules (BMs) to counteract the ZIKV through virtual screening and in vitro investigations. Virtual screening has identified doramectin, pinocembrin, he...
Source: Infectious Disorders Drug Targets - February 6, 2024 Category: Infectious Diseases Authors: Kiran Dobhal Ruchika Garg Alka Singh Amit Semwal Source Type: research
Mycobacterium flavescens Infection - An Unusual Case of Prosthetic Joint Infection
DISCUSSION: Mycobacterium spp. related PJIs manifest clinical features similar to other bacteria-causing PJIs, such as warm, indurated edema at the surgical site resulting in wound dehiscence and joint effusion. Diagnosis of Mycobacterium spp. related PJIs includes history and physical exami-nation findings, serum inflammatory markers, synovial fluid analysis, and culture. Concurrently with surgical interventions, utilization of antimicrobial agents provides additional control in My-cobacterium-related PJI. Mycobacterium flavescens should be included among other NTMs as a possible cause of PJIs.PMID:38314682 | DOI:10.2174/...
Source: Infectious Disorders Drug Targets - February 5, 2024 Category: Infectious Diseases Authors: Peter Holleb Srijisnu De Suresh Antony Source Type: research
An Insight into the Repurposing of Phytoconstituents obtained from Delhi's Aravalli Biodiversity Park as Antifungal Agents
The objective was to predict or repurpose phyto-based antifungal compounds based on a dual target inhibition approach (Sterol-14-αdemethylase and HSP-90) using a case study. In pursuit of repurposing the phytochemicals as antifungal agents, a team of researchers visited Aravalli Biodiversity Park (ABP), Delhi, India, to collect information on available medicinal plants. From 45 plants, a total of 1149 ligands were collected, and virtual screening was performed using Schrodinger Suite 2016 software to get 83 hits against both the target proteins: Sterol-14-α-demethylase and HSP-90. After analysis of docking results, ligan...
Source: Infectious Disorders Drug Targets - February 2, 2024 Category: Infectious Diseases Authors: Amanpreet Kaur Kalicharan Sharma Neetika Sharma Geeta Aggarwal Source Type: research
Actinomyces-induced Osteomyelitis of the Mandible - A Rare Disease
CONCLUSION: In summary, jaw osteomyelitis caused by Actinomyces should always be part of the differential diagnosis; as these organisms are commensal flora, the symptoms manifested are nonspecific, and such a diagnosis could be easily missed, resulting in delay of care and disease progression.PMID:38299277 | DOI:10.2174/0118715265275102231217155015 (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - February 1, 2024 Category: Infectious Diseases Authors: Caleb Nieves-Velez Gilberto Rivera-Gonzalez Suresh Antony Source Type: research
Estimating Hidden Population Size of COVID-19 Using Respondent- Driven Sampling Method - A Systematic Review
CONCLUSIONS: In general, our study illustrates the efficacy of RDS sampling in the estimation of undetected asymptomatic cases with high cost-effectiveness due to its relatively trouble-free and low-cost methods of sampling the population. This method would be valuable in probable future epidemics.PMID:38299412 | DOI:10.2174/0118715265277789240110043215 (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - February 1, 2024 Category: Infectious Diseases Authors: Seyed Ahmad Seyed Alinaghi Arian Afzalian Mohsen Dashti Afsaneh Ghasemzadeh Zohal Parmoon Ramin Shahidi Sanaz Varshochi Ava Pashaei Samaneh Mohammadi Fatemeh Khajeh Akhtaran Amirali Karimi Khadijeh Nasiri Esmaeil Mehraeen Daniel Hackett Source Type: research
Advancements in Nanotechnology for Enhanced Antifungal Drug Delivery: A Comprehensive Review
Infect Disord Drug Targets. 2024;24(2):e021123223053. doi: 10.2174/0118715265266257231022134933.ABSTRACTInfections caused by fungi can be mildly bothersome or fatal, causing life-threatening conditions or even death. Antifungal drugs have used synthetic chemicals, organic compounds, and phytoconstituents in their formulations to treat fungal infections. Research into novel antifungal drugs has progressed more rapidly than into antibacterial treatments. This can be attributed to the low resistance of fungal infections to antifungal bioactivities and the relatively low incidence of these diseases. Carrier systems based on na...
Source: Infectious Disorders Drug Targets - January 31, 2024 Category: Infectious Diseases Authors: Rajat Srivastava Ajay Kumar Singh Rawat Manoj Kumar Mishra Amit Kumar Patel Source Type: research
Two Birds with One Stone: Drug Regime Targets Viral Pathogenesis Phases and COVID-19 ARDS at the Same Time
CONCLUSION: In the current study, drug repurposing and high throughput docking methods have been employed to develop combination drug regimens as multiple-molecule drugs for the therapy of COVID-19 and ARDS based on a multiple-target therapy strategy. This approach offers a promising avenue for the treatment of COVID-19 and ARDS, and highlights the potential benefits of drug repurposing in the fight against the current pandemic.PMID:38288808 | DOI:10.2174/0118715265270637240107153121 (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - January 30, 2024 Category: Infectious Diseases Authors: Ghazaleh Ghavami Soroush Sardari Source Type: research
Stratified Mucin-Producing Intraepithelial Lesion of the Cervix in an HPV- 16 Positive Woman: A Rare Encounter
CONCLUSION: SMILE is a rare variant of AIS, which is often missed on cytological screening of the cervix. It is commonly associated with high-risk types of HPV. Hence, incorporating HPV testing in the screening of cervical cancer is important and recommended to increase the overall sensitivity of screening for adenocarcinoma lesions.PMID:38288809 | DOI:10.2174/0118715265284722240110114107 (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - January 30, 2024 Category: Infectious Diseases Authors: Naina Kumar Mishu Mangla Seetu Palo Spandana Gabbeta J Aparna Source Type: research
Strategies to Overcome Antimicrobial Resistance in Nosocomial Infections, A Review and Update
Infect Disord Drug Targets. 2024 Jan 26. doi: 10.2174/0118715265276529231214105423. Online ahead of print.ABSTRACTNosocomial infections, also known as healthcare-associated infections, are a signif-icant global concern due to their strong association with high mortality and morbidity in both developed and developing countries. These infections are caused by a variety of pathogens, particularly the ESKAPE group of bacteria, which includes the six pathogens Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudo-monas aeruginosa, and Enterobacter spp. These bacteria have demonstrat...
Source: Infectious Disorders Drug Targets - January 29, 2024 Category: Infectious Diseases Authors: Nasim Bakhtiyari Safar Farajnia Samaneh Ghasemali Sahar Farajnia Ali Pourmohammad Shabnam Saeidvafa Source Type: research
Dog Bite Injury: Rusk Became a Risk - A Case Report
CONCLUSION: The global injuries caused by dog bites are the consequence of uncommon illnesses and often manifest as peri-orbital and ocular lesions. Most rabies cases occur in underserved rural and urban areas, with a high frequency of stray dogs without immunisation.PMID:38279737 | DOI:10.2174/0118715265277314231211045515 (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - January 27, 2024 Category: Infectious Diseases Authors: Sadasivam Nehru Pugazhenthan Thangaraju Nehru Cibee Hemasri Velmurugan Source Type: research
Leptospirosis Associated Digital Gangrene of Lower Extremities: Two Cases and Review of Literature
CONCLUSION: Apart from a high index of suspicion and awareness of unusual manifestations, serology plays a vital role in making an accurate and quick diagnosis to initiate appropriate therapy.PMID:38265373 | DOI:10.2174/0118715265256882231128074609 (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - January 24, 2024 Category: Infectious Diseases Authors: Anju Dinkar Jitendra Singh Mahima Yadav Source Type: research
Salmonella Typhi: A Review of Antibiogram Journey in Developing Countries
Infect Disord Drug Targets. 2024 Jan 23. doi: 10.2174/0118715265255339240102110929. Online ahead of print.ABSTRACTTyphoid fever poses a significant health challenge in low- and middleincome countries (LMiCs), impacting millions of individuals across various age groups. Its prevalence is particularly pronounced in South Asia. Factors contributing to its transmission in South Asia include rapid unplanned urbanization, urban-rural disparities, provision of poor water and sanitation facilities, and open defecation. The mortality rate of typhoid fever is up to 1%, and those who survive have a protracted period of poor health an...
Source: Infectious Disorders Drug Targets - January 24, 2024 Category: Infectious Diseases Authors: Lipika Singhal Diljot Sandhu Varsha Gupta Ivneet Kour Source Type: research
Disease X: Beyond Fear, Toward Preparedness
Infect Disord Drug Targets. 2024 Jan 23. doi: 10.2174/0118715265285021240104091449. Online ahead of print.ABSTRACTIn recent years, there has been a growing concern regarding the increasing incidence of infectious diseases with potential global transmission [1]. The World Health Organization (WHO) coined the phrase "Disease X" to denote a theoretical infectious disease that has not yet been detected but has the capacity to cause a global pandemic. Disease X denotes an unidentified pathogenic agent with the potential to instigate a forthcoming global outbreak [2]. Commencing with a convened gathering on the 18th of November ...
Source: Infectious Disorders Drug Targets - January 24, 2024 Category: Infectious Diseases Authors: Rajendra Awasthi Source Type: research
A New-fangled COVID-19 Variant, Eris, Might be the One to Lookout in 2023 or far from Over
Infect Disord Drug Targets. 2024 Jan 22. doi: 10.2174/0118715265276833240105110046. Online ahead of print.ABSTRACTCoronavirus Disease-19 (COVID-19) is an infectious disease brought on by the extremely pathogenic and contagious severe acute respiratory syndrome-virus-2 (SARS-CoV-2). The agenda for the COVID-19 pandemic is dynamic and includes recent developments. Seven variants under monitoring (VUMs), one variant of interest (VOI), XBB.1.5, and their offspring lineages are currently being actively monitored by WHO. The VUMs are BA.2.75, CH.1.1, BQ.1, XBB (with the exception of XBB.1.5, XBB.1.16, and XBB.1.9.1), XBF, and XB...
Source: Infectious Disorders Drug Targets - January 23, 2024 Category: Infectious Diseases Authors: Suman Kumar Ray Sukhes Mukherjee Source Type: research
