Monocyte Count as a Prognostic Biomarker in Patients with Idiopathic Pulmonary Fibrosis.
Abstract Rationale: There is an urgent need for simple, cost-effective prognostic biomarkers for idiopathic pulmonary fibrosis (IPF); biomarkers that show potential include monocyte count. Objectives: We used pooled data from pirfenidone and interferon gamma-1b trials to explore the association between monocyte count and prognosis in patients with IPF. Methods: This retrospective pooled analysis included patients (active and placebo arms) from four Phase III, randomized, placebo-controlled trials: ASCEND (NCT01366209), CAPACITY (NCT00287729 and NCT00287716), and INSPIRE (NCT00075998). Outcomes included IPF progres...
Source: American Journal of Respiratory and Critical Care Medicine - January 12, 2021 Category: Respiratory Medicine Authors: Kreuter M, Lee JS, Tzouvelekis A, Oldham JM, Molyneaux PL, Weycker D, Atwood M, Kirchgaessler KU, Maher TM Tags: Am J Respir Crit Care Med Source Type: research

A Note on Common Apathy Versus Hypoactive Delirium in Critical Illness.
PMID: 33434454 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - January 12, 2021 Category: Respiratory Medicine Authors: Schieveld JNM, Strik JJMH Tags: Am J Respir Crit Care Med Source Type: research

Reply to: Are Ground Glass Opacities on HRCT a Manifestation of Airway Disease?
PMID: 33434473 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - January 12, 2021 Category: Respiratory Medicine Authors: Remy-Jardin M, Wilson KC, Raghu G Tags: Am J Respir Crit Care Med Source Type: research

Are Ground Glass Opacities on HRCT a Manifestation of Airway Disease?
lil M PMID: 33434474 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - January 12, 2021 Category: Respiratory Medicine Authors: Morán-Mendoza O, Khalil M Tags: Am J Respir Crit Care Med Source Type: research

Where is the Cystic Fibrosis Transmembrane Conductance Regulator?
PMID: 33428551 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - January 11, 2021 Category: Respiratory Medicine Authors: Barbry P, Marcet B, Caballero I Tags: Am J Respir Crit Care Med Source Type: research

Effect of Simulated Obstructive Apnea on Thoracic Fluid Volume and Airway Narrowing in Asthma.
PMID: 33428855 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - January 11, 2021 Category: Respiratory Medicine Authors: Cao X, Bradley TD, Bhatawadekar SA, Saha S, Tarlo SM, Stanbrook MB, Inman MD, Rana K, Dandurand RJ, Yadollahi A Tags: Am J Respir Crit Care Med Source Type: research

Professor Pangloss and the Pangenome: Does Staphylococcus aureus Have the Best of All Possible Worlds?
PMID: 33428861 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - January 11, 2021 Category: Respiratory Medicine Authors: Harrison F, Smyth AR Tags: Am J Respir Crit Care Med Source Type: research

Comparative Effectiveness of Protective Ventilation Strategies for Moderate and Severe ARDS: Network Meta-Analysis.
CONCLUSIONS: These findings suggest that combining low Vt with prone ventilation is associated with the greatest reduction in mortality for critically ill adults with moderate to severe ARDS. PMID: 33406009 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - January 6, 2021 Category: Respiratory Medicine Authors: Sud S, Friedrich JO, Adhikari NK, Fan E, Ferguson ND, Guyatt G, Meade MO Tags: Am J Respir Crit Care Med Source Type: research

Antigen-specific T Cell Activation Distinguishes Between Recent and Remote Tuberculosis Infection.
CONCLUSION: The ΔHLA-DR biomarker can identify individuals with recent QuantiFERON-TB conversion and those with disease progression, allowing targeted provision of preventive treatment to those at highest risk of tuberculosis. Further validation studies of this novel immune biomarker in various settings and populations at risk are warranted. PMID: 33406011 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - January 6, 2021 Category: Respiratory Medicine Authors: Mpande CAM, Musvosvi M, Rozot V, Mosito B, Reid TD, Schreuder C, Lloyd T, Bilek N, Huang H, Obermoser G, Davis MM, Ruhwald M, Hatherill M, Scriba TJ, Nemes E, ACS Study Team Tags: Am J Respir Crit Care Med Source Type: research

Positive End-Expiratory Pressure, Pleural Pressure, and Regional Compliance During Pronation: An Experimental Study.
Abstract RATIONALE: The physiological basis of lung protection and the impact of PEEP during pronation in ARDS are not fully elucidated. OBJECTIVES: To compare pleural pressure (Ppl) gradient, ventilation distribution and regional compliance between dependent and non-dependent lung, and investigate the effect of PEEP during supination and pronation. METHODS: We used a 2-hit model of lung injury (saline lavage and high-volume ventilation) in 14 mechanically ventilated pigs and studied supine and prone position. Global and regional lung mechanics including Ppl and distribution of ventilation (Electrical Im...
Source: American Journal of Respiratory and Critical Care Medicine - January 6, 2021 Category: Respiratory Medicine Authors: Katira BH, Osada K, Engelberts D, Bastia L, Damiani LF, Li X, Chen H, Yoshida T, Amato MBP, Ferguson ND, Post M, Kavanagh BP, Brochard LJ Tags: Am J Respir Crit Care Med Source Type: research

The Sleep Apnea-specific Pulse Rate Response Predicts Cardiovascular Morbidity and Mortality.
CONCLUSIONS: Individuals with OSA who demonstrate elevated pulse rate response are at increased risk of cardiovascular morbidity and mortality. This study identifies a prognostic biomarker for OSA that appears useful for risk stratification and patient selection for future clinical trials. PMID: 33406013 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - January 6, 2021 Category: Respiratory Medicine Authors: Azarbarzin A, Sands SA, Younes M, Taranto-Montemurro L, Sofer T, Vena D, Alex RM, Kim SW, Gottlieb DJ, White DP, Redline S, Wellman A Tags: Am J Respir Crit Care Med Source Type: research

Similarity of Lung Ultrasound Image in Patients with COVID-19 and COVID-like Illnesses.
PMID: 33406373 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - January 6, 2021 Category: Respiratory Medicine Authors: Buda N, Cylwik J, Kwiecińska R Tags: Am J Respir Crit Care Med Source Type: research

Plasma Soluble Suppression of Tumerogenicity-2 Associates with Ventilator Liberation in Acute Hypoxemic Respiratory Failure.
CONCLUSIONS: Using sST2 concentrations to guide ventilator management may more accurately reflect underlying lung injury and outperform traditional measures of readiness for ventilator liberation. PMID: 33400890 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - January 5, 2021 Category: Respiratory Medicine Authors: Alladina J, Levy SD, Cho JL, Brait KL, Rao SR, Camacho A, Hibbert KA, Harris RS, Medoff BD, Januzzi JL, Thompson BT, Bajwa EK Tags: Am J Respir Crit Care Med Source Type: research

Respiratory Effects of Sedentary Ozone Exposure at the 70 ppb National Ambient Air Quality Standard: A Randomized Clinical Trial.
PMID: 33400891 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - January 5, 2021 Category: Respiratory Medicine Authors: Hernandez ML, Ivins S, Chason K, Burbank AJ, Rebuli ME, Kobernick A, Schworer SA, Zhou H, Alexis NE, Peden DB Tags: Am J Respir Crit Care Med Source Type: research

Congenital Tracheo-esophageal Fistula in an Adult.
PMID: 33393880 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - January 4, 2021 Category: Respiratory Medicine Authors: Nakazawa S, Yajima T, Shirabe K Tags: Am J Respir Crit Care Med Source Type: research

Travel and Sleep.
PMID: 33385219 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - January 1, 2021 Category: Respiratory Medicine Authors: Shah P, Hadeh A Tags: Am J Respir Crit Care Med Source Type: research

Informing Healthcare Decisions with Observational Research Assessing Causal Effect. An Official American Thoracic Society Research Statement.
Conclusions: Observational studies should be considered in developing clinical practice guidelines and in making clinical decisions. PMID: 33385220 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - January 1, 2021 Category: Respiratory Medicine Authors: Gershon AS, Lindenauer PK, Wilson KC, Rose L, Walkey AJ, Sadatsafavi M, Anstrom KJ, Au DH, Bender BG, Brookhart MA, Dweik RA, Han MK, Joo MJ, Lavergne V, Mehta AB, Miravitlles M, Mularski RA, Roche N, Oren E, Riekert KA, Schoenberg NC, Stukel TA, Weiss CH Tags: Am J Respir Crit Care Med Source Type: research

Erratum: Severe Acute Kidney Injury in Patients with COVID-19 and Acute Respiratory Distress Syndrome.
Authors: PMID: 33385221 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - January 1, 2021 Category: Respiratory Medicine Tags: Am J Respir Crit Care Med Source Type: research

Erratum: Diagnosis of Hypersensitivity Pneumonitis in Adults: An Official ATS/JRS/ALAT Clinical Practice Guideline.
Authors: PMID: 33385222 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - January 1, 2021 Category: Respiratory Medicine Tags: Am J Respir Crit Care Med Source Type: research

Predicting Behavioral Problems from SDB Trajectories: Not An Easy Game!
PMID: 33352057 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 22, 2020 Category: Respiratory Medicine Authors: Kheirandish-Gozal L, Katz SL Tags: Am J Respir Crit Care Med Source Type: research

Invasive Pulmonary Aspergillosis Goes Viral Again?
PMID: 33352060 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 22, 2020 Category: Respiratory Medicine Authors: Wauters J, Lamoth F, Rijnders BJ, Calandra T Tags: Am J Respir Crit Care Med Source Type: research

Lung Ultrasound to Monitor Extremely Preterm Infants and Predict BPD: Multicenter Longitudinal Cohort Study.
Abstract RATIONALE: Lung ultrasound is useful in critically ill patients with acute respiratory failure. Given its characteristics, it could be also useful in extremely preterm infants with evolving chronic respiratory failure, as we lack accurate imaging tools to monitor them. OBJECTIVES: To verify if lung ultrasound can monitor lung aeration and function, and has good reliability to predict bronchopulmonary dysplasia in extremely preterm neonates. METHODS: Multicenter, international, prospective, longitudinal, cohort, diagnostic accuracy study consecutively enrolling inborn neonates with gestational ag...
Source: American Journal of Respiratory and Critical Care Medicine - December 22, 2020 Category: Respiratory Medicine Authors: Loi B, Vigo G, Baraldi E, Raimondi F, Carnielli VP, Mosca F, De Luca D, LUSTRE (Lung UltraSound To pReterm nEonates) study group Tags: Am J Respir Crit Care Med Source Type: research

CPAP Restores Declarative Memory Deficit in Obstructive Sleep Apnea.
PMID: 33347378 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 21, 2020 Category: Respiratory Medicine Authors: Djonlagic IE, Guo M, Igue M, Kishore D, Stickgold R, Malhotra A Tags: Am J Respir Crit Care Med Source Type: research

Preload Independence is Associated with Extubation Failure in Simple Weaning Patients: A Multicentre Cohort Study.
ti MM PMID: 33347386 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 21, 2020 Category: Respiratory Medicine Authors: Porto DB, Beltrão BA, Medeiros FS, Santos Pellegrini JA, Boniatti MM Tags: Am J Respir Crit Care Med Source Type: research

Trends in Chronic Obstructive Pulmonary Disease Prevalence, Incidence, and Health Services Use in Younger Adults in Ontario, Canada, 2006 to 2016.
PMID: 33347389 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 21, 2020 Category: Respiratory Medicine Authors: Gershon AS, McGihon RE, Luo J, Blazer AJ, Kendzerska T, To T, Aaron SD Tags: Am J Respir Crit Care Med Source Type: research

Lipid Laden Macrophages are not Unique to EVALI Patients.
PMID: 33332247 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 17, 2020 Category: Respiratory Medicine Authors: Ghosh A, Ahmad S, Coakley RD, Sassano MF, Alexis NE, Tarran R Tags: Am J Respir Crit Care Med Source Type: research

Spirometric Classifications of COPD Severity as Predictive Markers for Clinical Outcomes: The HUNT Study.
PMID: 33332249 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 17, 2020 Category: Respiratory Medicine Authors: Bhatta L, Leivseth L, Mai XM, Henriksen AH, Carslake D, Chen Y, Martinez-Camblor P, Langhammer A, Brumpton BM Tags: Am J Respir Crit Care Med Source Type: research

Inflammatory Endotype Associated Airway Microbiome in COPD Clinical Stability and Exacerbations - A Multi-Cohort Longitudinal Analysis.
CONCLUSIONS: The airway microbiome can stratify neutrophilic COPD into subgroups that justify different therapies. Neutrophilic and eosinophilic COPD are inter-changeable in some patients. Monitoring temporal variability of the airway microbiome may track patient inflammatory status over time. PMID: 33332995 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 17, 2020 Category: Respiratory Medicine Authors: Wang Z, Locantore N, Haldar K, Ramsheh MY, Beech AS, Ma W, Brown JR, Tal-Singer R, Barer MR, Bafadhel M, Donaldson GC, Wedzicha JA, Singh D, Wilkinson TMA, Miller BE, Brightling CE Tags: Am J Respir Crit Care Med Source Type: research

Persistent Lymphocytopenia Does Not Increase Nosocomial Infection Risk in the ICU.
PMID: 33332996 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 17, 2020 Category: Respiratory Medicine Authors: Varkila MRJ, Marrec L, Daix T, Hoefer IE, Haitjema S, Bonten MJM, Cremer OL Tags: Am J Respir Crit Care Med Source Type: research

Preclinical Development of Virulence Attenuated Streptococcus pneumoniae Strains Able to Enhance Protective Immunity Against Pneumococcal Infection.
PMID: 33332997 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 17, 2020 Category: Respiratory Medicine Authors: Ramos-Sevillano E, Ercoli G, Felgner P, Ramiro de Assis R, Nakajima R, Goldblatt D, Heyderman RS, Gordon SB, Ferreira DM, Brown JS Tags: Am J Respir Crit Care Med Source Type: research

Severe Adult Asthmas: Integrating Clinical Features, Biology and Therapeutics to Improve Outcomes.
Abstract Evaluation and effective management of asthma and in particular severe asthma remains at the core of pulmonary practice. Over the last 20-30 years, there is increasing appreciation that "severe asthma", encompasses multiple different subgroups or phenotypes each with differing presentations. Using clinical phenotyping, in combination. with rapidly advancing molecular tools and targeted monoclonal antibodies (human knock-outs), the understanding of these phenotypes and our ability to treat them have greatly advanced. Type-2 (T2) Hi and Lo severe asthmas are now easily identified. Fraction exhaled...
Source: American Journal of Respiratory and Critical Care Medicine - December 16, 2020 Category: Respiratory Medicine Authors: Wenzel SE Tags: Am J Respir Crit Care Med Source Type: research

High Prevalence of Pulmonary Sequelae at 3 Months After Hospital Discharge in Mechanically Ventilated COVID-19 Survivors.
PMID: 33326353 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 16, 2020 Category: Respiratory Medicine Authors: van Gassel RJJ, Bels JLM, Raafs A, van Bussel BCT, van de Poll MCG, Simons SO, van der Meer LWL, Gietema HA, Posthuma R, van Santen S Tags: Am J Respir Crit Care Med Source Type: research

CC16 Binding to α4β1 Integrin (VLA-4) Protects Against Mycoplasma pneumoniae Infection.
Conclusions: We discovered a novel receptor for CC16, VLA-4, which has important mechanistic implications for the role of CC16 in circulation as well as in the lung compartment. PMID: 33326355 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 16, 2020 Category: Respiratory Medicine Authors: Johnson MD, Younis US, Menghani SV, Addison KJ, Whalen M, Pilon AL, Cress AE, Polverino F, Romanoski C, Kraft M, Martinez FD, Guerra S, Ledford JG Tags: Am J Respir Crit Care Med Source Type: research

Re-Igniting the TORCH: COPD Mortality and Inhaled Corticosteroids Re-Visited.
PMID: 33326362 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 16, 2020 Category: Respiratory Medicine Authors: Calverley P Tags: Am J Respir Crit Care Med Source Type: research

SARS-CoV-2 Detected on Environmental Fomites for both Asymptomatic and Symptomatic COVID-19 Patients.
PMID: 33326364 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 16, 2020 Category: Respiratory Medicine Authors: Yang M, Li L, Huang T, Li S, Zhang M, Yang Y, Jiang Y, Li X, Yuan J, Liu Y Tags: Am J Respir Crit Care Med Source Type: research

What Is a Spontaneous Pneumothorax?
PMID: 33320071 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 15, 2020 Category: Respiratory Medicine Authors: Paskaradevan J, Sayad E, Sockrider M Tags: Am J Respir Crit Care Med Source Type: research

Erratum: COVID-19-related Genes in Sputum Cells in Asthma: Relationship to Demographic Features and Corticosteroids.
PMID: 33320072 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 15, 2020 Category: Respiratory Medicine Authors: Peters MC, Fahy JV Tags: Am J Respir Crit Care Med Source Type: research

Erratum: A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-Catenin.
Erratum: A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-Catenin. Am J Respir Crit Care Med. 2020 Dec 15;202(12):1746 Authors: PMID: 33320073 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 15, 2020 Category: Respiratory Medicine Tags: Am J Respir Crit Care Med Source Type: research

Kinetic Changes of Plasma Renin Levels Predict Acute Kidney Injury in Cardiac Surgery Patients.
Meersch M, Zarbock A Abstract RATIONALE: The Renin-Angiotensin-Aldosterone-System is a major pathway in regulating blood pressure, glomerular filtration, and fluid homeostasis. During inflammatory diseases, generation of angiotensin-II might be disturbed leading to increased renin levels. Cardiac surgery and the use of cardiopulmonary bypass both induce inflammatory response and cardiovascular instability which can contribute to acute kidney injury (AKI). OBJECTIVES: To investigate whether renin levels are associated with hypotension and AKI. METHODS: Single center, prospective, observational study amon...
Source: American Journal of Respiratory and Critical Care Medicine - December 15, 2020 Category: Respiratory Medicine Authors: Küllmar M, Saadat-Gilani K, Weiss R, Massoth C, Lagan A, Núñez Cortés M, Gerss J, Chawla LS, Fliser D, Meersch M, Zarbock A Tags: Am J Respir Crit Care Med Source Type: research

"Established" Respiratory Treatment in ARDS: Scientific Rigor or a Square Peg in a Round Hole?
"Established" Respiratory Treatment in ARDS: Scientific Rigor or a Square Peg in a Round Hole? Am J Respir Crit Care Med. 2020 Dec 15;: Authors: Camporota L, Gattinoni L, Marini JJ PMID: 33320794 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 15, 2020 Category: Respiratory Medicine Authors: Camporota L, Gattinoni L, Marini JJ Tags: Am J Respir Crit Care Med Source Type: research

Circulating BMP9 Protects the Pulmonary Endothelium During Inflammation-induced Lung Injury in Mice.
Abstract RATIONALE: Pulmonary endothelial permeability contributes to the high-permeability pulmonary edema that characterizes acute respiratory distress syndrome (ARDS). Circulating bone morphogeneic protein 9 (BMP9) is emerging as an important regulator of pulmonary vascular homeostasis. OBJECTIVE: To determine whether endogenous BMP9 plays a role in preserving pulmonary endothelial integrity, and whether loss of endogenous BMP9 occurs during lipopolysacharride (LPS) challenge. METHODS: A BMP9-neutralizing antibody was administrated to healthy adult mice and lung vasculature was examined. Potential mec...
Source: American Journal of Respiratory and Critical Care Medicine - December 15, 2020 Category: Respiratory Medicine Authors: Li W, Long L, Yang X, Tong Z, Southwood M, King R, Caruso P, Upton PD, Yang P, Bocobo GA, Nikolic I, Higuera A, Salmon RM, Jiang H, Lodge KM, Hoenderdos K, Baron RM, Yu PB, Condliffe AM, Summers C, Nourshargh S, Chilvers ER, Morrell NW Tags: Am J Respir Crit Care Med Source Type: research

Reply to: "Established" Respiratory Treatment in ARDS: Scientific Rigor or a Square Peg in a Round Hole?
Reply to: "Established" Respiratory Treatment in ARDS: Scientific Rigor or a Square Peg in a Round Hole? Am J Respir Crit Care Med. 2020 Dec 15;: Authors: Hardin CC PMID: 33320805 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 15, 2020 Category: Respiratory Medicine Authors: Hardin CC Tags: Am J Respir Crit Care Med Source Type: research

Secretory Cells Dominate Airway CFTR Expression and Function in Human Airway Superficial Epithelia.
CONCLUSIONS: Secretory cells dominate CFTR expression and function in human airway superficial epithelia. CFTR therapies may need to restore CFTR function to multiple cell types, with a focus on secretory cells. PMID: 33321047 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 15, 2020 Category: Respiratory Medicine Authors: Okuda K, Dang H, Kobayashi Y, Carraro G, Nakano S, Chen G, Kato T, Asakura T, Gilmore RC, Morton LC, Lee RE, Mascenik T, Yin WN, Barbosa Cardenas SM, O'Neal YK, Minnick CE, Chua M, Quinney NL, Gentzsch M, Anderson CW, Ghio A, Matsui H, Nagase T, Ostrowski Tags: Am J Respir Crit Care Med Source Type: research

Cigarette Smoke Directly Promotes Pulmonary Arterial Remodeling and Kv7.4 Channel Dysfunction.
CONCLUSIONS: Cigarette smoke directly contributes to pulmonary arterial remodeling through increased cell senescence, as well as vascular tone alterations due to diminished levels and function of the Kv7.4 channel. Strategies targeting these pathways may lead to novel therapies for COPD. PMID: 33306938 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 11, 2020 Category: Respiratory Medicine Authors: Sevilla-Montero J, Labrousse-Arias D, Fernández-Pérez C, Fernández-Blanco L, Barreira B, Mondéjar-Parreño G, Alfaro-Arnedo E, López IP, Pérez-Rial S, Peces-Barba G, Pichel JG, Peinado VI, Cogolludo Á, Calzada MJ Tags: Am J Respir Crit Care Med Source Type: research

Effects of a Cleaner Energy Intervention on Cardiopulmonary Outcomes in Peru: A Randomized Controlled Trial.
CONCLUSIONS: We did not find evidence of a difference in blood pressure, lung function or respiratory symptoms during the year-long cleaner energy intervention. Clinical trial registration available at www.clinicaltrials.gov, ID: NCT02994680. PMID: 33306939 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 11, 2020 Category: Respiratory Medicine Authors: Checkley W, Williams KN, Kephart JL, Fandiño-Del-Rio M, Steenland NK, Gonzales GF, Naeher LP, Harvey SA, Moulton LH, Davila-Roman VG, Goodman D, Tarazona-Meza C, Miele CH, Simkovich S, Chiang M, Chartier RT, Koehler K, CHAP trial Investigators Tags: Am J Respir Crit Care Med Source Type: research

Human Lung Resident Macrophages Co-localize with and Provide Co-stimulation to PD1hi Tissue Resident Memory T Cells.
CONCLUSIONS: Ex-vivo lung perfusion provides an innovative technique to study resident immune populations in humans. Human lung resident macrophages co-localize with and provide co-stimulation signaling to tissue resident memory T cells, augmenting their effector function. PMID: 33306940 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 11, 2020 Category: Respiratory Medicine Authors: Snyder ME, Sembrat J, Noda K, Myerburg MM, Craig A, Mitash N, Harano T, Furukawa M, Pilewski J, McDyer J, Rojas M, Sanchez P Tags: Am J Respir Crit Care Med Source Type: research

Trends in Intensive Care for Patients with COVID-19 in England, Wales and Northern Ireland.
CONCLUSIONS: The population of patients with COVID-19 admitted to ICU, and the processes of care in ICU, changed over the first wave of the epidemic. After adjustment for important risk factors, there was substantial improvement in patient outcomes. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/). PMID: 33306946 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 11, 2020 Category: Respiratory Medicine Authors: Doidge JC, Gould DW, Ferrando-Vivas P, Mouncey PR, Thomas K, Shankar-Hari M, Harrison DA, Rowan KM Tags: Am J Respir Crit Care Med Source Type: research

The Role of Individual and Neighborhood Factors on Racial Disparity in Respiratory Outcomes: Won't You Be My Neighbor?
PMID: 33296282 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 9, 2020 Category: Respiratory Medicine Authors: Quint JK, Bottle A Tags: Am J Respir Crit Care Med Source Type: research

Polyclonality, Shared Strains, and Convergent Evolution in Chronic CF S. aureus Airway Infection.
CONCLUSIONS: CF airways are frequently co-infected by multiple, genetically distinct S. aureus lineages, indicating that current clinical procedures for sampling isolates and selecting antibiotics are likely inadequate. Strains can be shared by patients in close domestic or clinical contact and undergo convergent evolution in key persistence and antimicrobial resistance genes, suggesting novel diagnostic and therapeutic approaches for future study. PMID: 33296290 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 9, 2020 Category: Respiratory Medicine Authors: Long DR, Wolter DJ, Lee M, Precit M, McLean K, Holmes E, Penewit K, Waalkes A, Hoffman LR, Salipante SJ Tags: Am J Respir Crit Care Med Source Type: research

A Pigmented Lung Pecoma.
PMID: 33285076 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 7, 2020 Category: Respiratory Medicine Authors: Onorati I, Kambouchner M, Martinod E Tags: Am J Respir Crit Care Med Source Type: research