Reply to: The Mystery of Futility of Appropriate Antibiotics for Co-Infection in COVID-19
Am J Respir Crit Care Med. 2021 Sep 21. doi: 10.1164/rccm.202108-1846LE. Online ahead of print.NO ABSTRACTPMID:34546857 | DOI:10.1164/rccm.202108-1846LE (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 21, 2021 Category: Respiratory Medicine Authors: Anahita Rouz é Julien Labreuche Saad Nseir all authors of “Early Bacterial Identification Among Intubated Patients with SARS-COV-2 or Influenza Pneumonia: A European Multicenter Comparative Cohort Study” Source Type: research

The Mystery of Futility of Appropriate Antibiotics for Co-Infection in COVID-19
Am J Respir Crit Care Med. 2021 Sep 21. doi: 10.1164/rccm.202107-1656LE. Online ahead of print.NO ABSTRACTPMID:34546862 | DOI:10.1164/rccm.202107-1656LE (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 21, 2021 Category: Respiratory Medicine Authors: Daisuke Kasugai Naruhiro Jingushi Norihiro Omote Yuichiro Shindo Yukari Goto Source Type: research

PAP Therapy-Quick Tips for Troubleshooting to Address Problems with Use
Am J Respir Crit Care Med. 2021 Sep 15;204(6):P11-P12. doi: 10.1164/rccm.2046P11.NO ABSTRACTPMID:34543160 | DOI:10.1164/rccm.2046P11 (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 20, 2021 Category: Respiratory Medicine Authors: Helena Schotland Source Type: research

Two Steps Forward: Improving the Management of Cystic Fibrosis Pulmonary Exacerbations
Am J Respir Crit Care Med. 2021 Sep 20. doi: 10.1164/rccm.202108-1939ED. Online ahead of print.NO ABSTRACTPMID:34543576 | DOI:10.1164/rccm.202108-1939ED (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 20, 2021 Category: Respiratory Medicine Authors: Valerie Waters Source Type: research

A Phase II Cluster-Crossover Randomized Trial of Fentanyl vs. Morphine for Analgosedation in Mechanically Ventilated Patients
Am J Respir Crit Care Med. 2021 Sep 20. doi: 10.1164/rccm.202106-1515OC. Online ahead of print.ABSTRACTRATIONALE: The continuous infusion of fentanyl or morphine is often prescribed to assist with analgesia and sedation (analgosedation) during mechanical ventilation.OBJECTIVES: To compare the effect of fentanyl vs. morphine on patient-centered outcomes in ventilated patients.METHODS: We conducted a cluster-randomized, cluster-crossover trial between July 2019 and August 2020 in two adult Intensive Care Units. We compared two continuous infusion regimens (fentanyl vs. morphine). One Intensive Care Unit was randomized to the...
Source: American Journal of Respiratory and Critical Care Medicine - September 20, 2021 Category: Respiratory Medicine Authors: Andrew J Casamento Ary Serpa Neto Marcus Young Mervin Lawrence Christina Taplin Glenn M Eastwood Angajendra Ghosh Rinaldo Bellomo Assessment of Opioid Administration to Lead to Analgesic Effects and Sedation in Intensive Care (ANALGESIC) trial centers Source Type: research

Using Isoniazid More Safely and More Effectively: The Time is Now
Am J Respir Crit Care Med. 2021 Sep 20. doi: 10.1164/rccm.202108-1938ED. Online ahead of print.NO ABSTRACTPMID:34543582 | DOI:10.1164/rccm.202108-1938ED (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 20, 2021 Category: Respiratory Medicine Authors: Neil W Schluger Source Type: research

Latent Class Analysis Reveals COVID-19-related ARDS Subgroups with Differential Responses to Corticosteroids
The objective of this study was to identify clinically relevant, novel subgroups in COVID-19-related ARDS, and compare them to previously described ARDS subphenotypes. Methods Eligible participants were adults with COVID-19 and ARDS at Columbia University Irving Medical Center. Latent class analysis (LCA) was used to identify subgroups with baseline clinical, respiratory, and laboratory data serving as partitioning variables. A previously-developed machine learning model was used to classify patients as the hypoinflammatory and hyperinflammatory subphenotypes. Baseline characteristics and clinical outcomes were compared be...
Source: American Journal of Respiratory and Critical Care Medicine - September 20, 2021 Category: Respiratory Medicine Authors: Pratik Sinha David Furfaro Matthew J Cummings Darryl Abrams Kevin Delucchi Manoj V Maddali June He Alison Thompson Michael Murn John Fountain Amanda Rosen Shelief Y Robbins-Juarez Matthew A Adan Tejus Satish Mahesh Madhavan Aakriti Gupta Alexander K Lyash Source Type: research

Dynamics of the Upper Respiratory Tract Microbiota and its Association with Mortality in COVID-19
Conclusions:URT microbiota dysbiosis is a remarkable manifestation of COVID-19; its association with mortality suggests it may reflect the interplay between pathogens, symbionts, and the host immune status. Whether URT microbiota could be used as a biomarker for the diagnosis and prognosis of respiratory diseases merits further investigation. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).PMID:34534435 | DOI:10.1164/rccm.202103-0814OC (Source: American Journal of Respiratory and C...
Source: American Journal of Respiratory and Critical Care Medicine - September 17, 2021 Category: Respiratory Medicine Authors: Lili Ren Yeming Wang Jiaxin Zhong Xia Li Yan Xiao Jie Li Jing Yang Guohui Fan Li Guo Zijie Shen Lu Kang Leisheng Shi Qiong Li Jizhou Li Lin Di Haibo Li Conghui Wang Ying Wang Xinming Wang Xiaohui Zou Jian Rao Li Zhang Jianbin Wang Yanyi Huang Bin Cao Jian Source Type: research

Follicular Helper-like T Cells in the Lung Highlight a Novel Role of B Cells in Sarcoidosis
CONCLUSIONS: Active T cell / B cell cooperation and local production of potentially pathogenic antibodies in the inflamed lung represents a novel pathomechanism in sarcoidosis and should be considered from both diagnostic and therapeutic perspectives.PMID:34534436 | DOI:10.1164/rccm.202012-4423OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 17, 2021 Category: Respiratory Medicine Authors: Laura Bauer Lisa Jasmin M üller Sarah M Volkers Frederik Heinrich Mir-Farzin Mashreghi Clemens Ruppert Leif E Sander Andreas Hutloff Source Type: research

Dynamics of the Upper Respiratory Tract Microbiota and its Association with Mortality in COVID-19
Conclusions:URT microbiota dysbiosis is a remarkable manifestation of COVID-19; its association with mortality suggests it may reflect the interplay between pathogens, symbionts, and the host immune status. Whether URT microbiota could be used as a biomarker for the diagnosis and prognosis of respiratory diseases merits further investigation. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).PMID:34534435 | DOI:10.1164/rccm.202103-0814OC (Source: American Journal of Respiratory and C...
Source: American Journal of Respiratory and Critical Care Medicine - September 17, 2021 Category: Respiratory Medicine Authors: Lili Ren Yeming Wang Jiaxin Zhong Xia Li Yan Xiao Jie Li Jing Yang Guohui Fan Li Guo Zijie Shen Lu Kang Leisheng Shi Qiong Li Jizhou Li Lin Di Haibo Li Conghui Wang Ying Wang Xinming Wang Xiaohui Zou Jian Rao Li Zhang Jianbin Wang Yanyi Huang Bin Cao Jian Source Type: research

Follicular Helper-like T Cells in the Lung Highlight a Novel Role of B Cells in Sarcoidosis
CONCLUSIONS: Active T cell / B cell cooperation and local production of potentially pathogenic antibodies in the inflamed lung represents a novel pathomechanism in sarcoidosis and should be considered from both diagnostic and therapeutic perspectives.PMID:34534436 | DOI:10.1164/rccm.202012-4423OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 17, 2021 Category: Respiratory Medicine Authors: Laura Bauer Lisa Jasmin M üller Sarah M Volkers Frederik Heinrich Mir-Farzin Mashreghi Clemens Ruppert Leif E Sander Andreas Hutloff Source Type: research

Longitudinal Dynamics of a Blood Transcriptomic Signature of Tuberculosis
Conclusions Positive RISK11 signature status is often transient, possibly due to intercurrent viral infection, highlighting potentially important challenges for implementation of these biomarkers as new tools for TB control. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:34520313 | DOI:10.1164/rccm.202103-0548OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 14, 2021 Category: Respiratory Medicine Authors: Humphrey Mulenga Munyaradzi Musvosvi Simon C Mendelsohn Adam Penn-Nicholson Stanley Kimbung Mbandi Andrew-Fiore Gartland Mich èle Tameris Simbarashe Mabwe Hadn Africa Nicole Bilek Fazlin Kafaar Shabaana A Khader Balie Carstens Katie Hadley Chris Hikuam M Source Type: research

Longitudinal Dynamics of a Blood Transcriptomic Signature of Tuberculosis
Conclusions Positive RISK11 signature status is often transient, possibly due to intercurrent viral infection, highlighting potentially important challenges for implementation of these biomarkers as new tools for TB control. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:34520313 | DOI:10.1164/rccm.202103-0548OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 14, 2021 Category: Respiratory Medicine Authors: Humphrey Mulenga Munyaradzi Musvosvi Simon C Mendelsohn Adam Penn-Nicholson Stanley Kimbung Mbandi Andrew-Fiore Gartland Mich èle Tameris Simbarashe Mabwe Hadn Africa Nicole Bilek Fazlin Kafaar Shabaana A Khader Balie Carstens Katie Hadley Chris Hikuam M Source Type: research

Longitudinal Dynamics of a Blood Transcriptomic Signature of Tuberculosis
Conclusions Positive RISK11 signature status is often transient, possibly due to intercurrent viral infection, highlighting potentially important challenges for implementation of these biomarkers as new tools for TB control. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:34520313 | DOI:10.1164/rccm.202103-0548OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 14, 2021 Category: Respiratory Medicine Authors: Humphrey Mulenga Munyaradzi Musvosvi Simon C Mendelsohn Adam Penn-Nicholson Stanley Kimbung Mbandi Andrew-Fiore Gartland Mich èle Tameris Simbarashe Mabwe Hadn Africa Nicole Bilek Fazlin Kafaar Shabaana A Khader Balie Carstens Katie Hadley Chris Hikuam M Source Type: research

Longitudinal Dynamics of a Blood Transcriptomic Signature of Tuberculosis
Conclusions Positive RISK11 signature status is often transient, possibly due to intercurrent viral infection, highlighting potentially important challenges for implementation of these biomarkers as new tools for TB control. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:34520313 | DOI:10.1164/rccm.202103-0548OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 14, 2021 Category: Respiratory Medicine Authors: Humphrey Mulenga Munyaradzi Musvosvi Simon C Mendelsohn Adam Penn-Nicholson Stanley Kimbung Mbandi Andrew-Fiore Gartland Mich èle Tameris Simbarashe Mabwe Hadn Africa Nicole Bilek Fazlin Kafaar Shabaana A Khader Balie Carstens Katie Hadley Chris Hikuam M Source Type: research

Longitudinal Dynamics of a Blood Transcriptomic Signature of Tuberculosis
Conclusions Positive RISK11 signature status is often transient, possibly due to intercurrent viral infection, highlighting potentially important challenges for implementation of these biomarkers as new tools for TB control. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:34520313 | DOI:10.1164/rccm.202103-0548OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 14, 2021 Category: Respiratory Medicine Authors: Humphrey Mulenga Munyaradzi Musvosvi Simon C Mendelsohn Adam Penn-Nicholson Stanley Kimbung Mbandi Andrew-Fiore Gartland Mich èle Tameris Simbarashe Mabwe Hadn Africa Nicole Bilek Fazlin Kafaar Shabaana A Khader Balie Carstens Katie Hadley Chris Hikuam M Source Type: research

Modern Lung Magnetic Resonance Imaging to Screen for Pulmonary Complications in Patients with Dyskeratosis Congenita
Am J Respir Crit Care Med. 2021 Sep 13. doi: 10.1164/rccm.202103-0736LE. Online ahead of print.NO ABSTRACTPMID:34516939 | DOI:10.1164/rccm.202103-0736LE (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 13, 2021 Category: Respiratory Medicine Authors: Laura L Walkup Kasiani C Myers Matthew M Willmering Parinda A Mehta Adam S Nelson Robert J Fleck Jason C Woods Stella M Davies Christopher T Towe Source Type: research

Ensuring Access to Albuterol in Schools: From Policy to Implementation. An Official ATS/AANMA/ALA/NASN Policy Statement
Conclusions: Stock albuterol in schools is a safe, practical, and potentially life-saving option for children with asthma, whether asthma is diagnosed or undiagnosed, who lack access to their personal quick-relief medication. Legislation is imperative for aiding in the adoption and implementation of school stock albuterol policies, and key policy inclusions can lay the groundwork for success. Future work should focus on passing legislation in all states, implementing policy in schools, and evaluating the impact of such programs on academic and health outcomes.PMID:34499024 | DOI:10.1164/rccm.202106-1550ST (Source: American...
Source: American Journal of Respiratory and Critical Care Medicine - September 9, 2021 Category: Respiratory Medicine Authors: Anna Volerman Ashley A Lowe Andrea A Pappalardo Charmayne M C Anderson Kathryn V Blake Tyra Bryant-Stephens Thomas Carr Heather Carter Lisa Cicutto Joe K Gerald Tina Miller Nuala S Moore Hanna Phan S Christy Sadreameli Andrea Tanner Tonya A Winders Lynn B Source Type: research

Inhaled Marijuana and the Lungs
Am J Respir Crit Care Med. 2021 Sep 1;204(5):P9-P10. doi: 10.1164/rccm.2044P9.NO ABSTRACTPMID:34499025 | DOI:10.1164/rccm.2044P9 (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 9, 2021 Category: Respiratory Medicine Authors: Sarah Neff Matthew G Drake Christopher G Slatore Ellen Burnham Source Type: research

Simulation of Ventilator Allocation in Critically Ill Patients with COVID-19
Am J Respir Crit Care Med. 2021 Sep 9. doi: 10.1164/rccm.202106-1453LE. Online ahead of print.NO ABSTRACTPMID:34499587 | DOI:10.1164/rccm.202106-1453LE (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 9, 2021 Category: Respiratory Medicine Authors: Sivasubramanium V Bhavani Yuan Luo William D Miller Lazaro N Sanchez-Pinto Xuan Han Chengsheng Mao Burhaneddin Sandikci Monica E Peek Craig M Coopersmith Kelly N Michelson William F Parker Source Type: research

Reduced Exercise Capacity in Adults Born Very Low Birth Weight: A Population-Based Cohort Study
Am J Respir Crit Care Med. 2021 Sep 9. doi: 10.1164/rccm.202103-0755OC. Online ahead of print.ABSTRACTRATIONALE: Population-based data regarding the consequences of very low birth weight (VLBW) and bronchopulmonary dysplasia (BPD) on adult exercise capacity is limited.OBJECTIVES: To compare exercise capacity in a national VLBW cohort with term-born controls and explore factors contributing to the differences.METHODS: At 26-30 years of age, 228 VLBW survivors and 100 controls underwent lung function tests, cardiopulmonary exercise testing and assessment of resting cardiac structure/function using echocardiography. Data on s...
Source: American Journal of Respiratory and Critical Care Medicine - September 9, 2021 Category: Respiratory Medicine Authors: Jun Yang Michael J Epton Sarah L Harris John Horwood Rachel A Kingsford Richard Troughton Charlotte Greer Brian A Darlow Source Type: research

Ensuring Access to Albuterol in Schools: From Policy to Implementation. An Official ATS/AANMA/ALA/NASN Policy Statement
Conclusions: Stock albuterol in schools is a safe, practical, and potentially life-saving option for children with asthma, whether asthma is diagnosed or undiagnosed, who lack access to their personal quick-relief medication. Legislation is imperative for aiding in the adoption and implementation of school stock albuterol policies, and key policy inclusions can lay the groundwork for success. Future work should focus on passing legislation in all states, implementing policy in schools, and evaluating the impact of such programs on academic and health outcomes.PMID:34499024 | DOI:10.1164/rccm.202106-1550ST (Source: American...
Source: American Journal of Respiratory and Critical Care Medicine - September 9, 2021 Category: Respiratory Medicine Authors: Anna Volerman Ashley A Lowe Andrea A Pappalardo Charmayne M C Anderson Kathryn V Blake Tyra Bryant-Stephens Thomas Carr Heather Carter Lisa Cicutto Joe K Gerald Tina Miller Nuala S Moore Hanna Phan S Christy Sadreameli Andrea Tanner Tonya A Winders Lynn B Source Type: research

Inhaled Marijuana and the Lungs
Am J Respir Crit Care Med. 2021 Sep 1;204(5):P9-P10. doi: 10.1164/rccm.2044P9.NO ABSTRACTPMID:34499025 | DOI:10.1164/rccm.2044P9 (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 9, 2021 Category: Respiratory Medicine Authors: Sarah Neff Matthew G Drake Christopher G Slatore Ellen Burnham Source Type: research

Simulation of Ventilator Allocation in Critically Ill Patients with COVID-19
Am J Respir Crit Care Med. 2021 Sep 9. doi: 10.1164/rccm.202106-1453LE. Online ahead of print.NO ABSTRACTPMID:34499587 | DOI:10.1164/rccm.202106-1453LE (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 9, 2021 Category: Respiratory Medicine Authors: Sivasubramanium V Bhavani Yuan Luo William D Miller Lazaro N Sanchez-Pinto Xuan Han Chengsheng Mao Burhaneddin Sandikci Monica E Peek Craig M Coopersmith Kelly N Michelson William F Parker Source Type: research

Reduced Exercise Capacity in Adults Born Very Low Birth Weight: A Population-Based Cohort Study
Am J Respir Crit Care Med. 2021 Sep 9. doi: 10.1164/rccm.202103-0755OC. Online ahead of print.ABSTRACTRATIONALE: Population-based data regarding the consequences of very low birth weight (VLBW) and bronchopulmonary dysplasia (BPD) on adult exercise capacity is limited.OBJECTIVES: To compare exercise capacity in a national VLBW cohort with term-born controls and explore factors contributing to the differences.METHODS: At 26-30 years of age, 228 VLBW survivors and 100 controls underwent lung function tests, cardiopulmonary exercise testing and assessment of resting cardiac structure/function using echocardiography. Data on s...
Source: American Journal of Respiratory and Critical Care Medicine - September 9, 2021 Category: Respiratory Medicine Authors: Jun Yang Michael J Epton Sarah L Harris John Horwood Rachel A Kingsford Richard Troughton Charlotte Greer Brian A Darlow Source Type: research

Ensuring Access to Albuterol in Schools: From Policy to Implementation. An Official ATS/AANMA/ALA/NASN Policy Statement
Conclusions: Stock albuterol in schools is a safe, practical, and potentially life-saving option for children with asthma, whether asthma is diagnosed or undiagnosed, who lack access to their personal quick-relief medication. Legislation is imperative for aiding in the adoption and implementation of school stock albuterol policies, and key policy inclusions can lay the groundwork for success. Future work should focus on passing legislation in all states, implementing policy in schools, and evaluating the impact of such programs on academic and health outcomes.PMID:34499024 | DOI:10.1164/rccm.202106-1550ST (Source: American...
Source: American Journal of Respiratory and Critical Care Medicine - September 9, 2021 Category: Respiratory Medicine Authors: Anna Volerman Ashley A Lowe Andrea A Pappalardo Charmayne M C Anderson Kathryn V Blake Tyra Bryant-Stephens Thomas Carr Heather Carter Lisa Cicutto Joe K Gerald Tina Miller Nuala S Moore Hanna Phan S Christy Sadreameli Andrea Tanner Tonya A Winders Lynn B Source Type: research

Inhaled Marijuana and the Lungs
Am J Respir Crit Care Med. 2021 Sep 1;204(5):P9-P10. doi: 10.1164/rccm.2044P9.NO ABSTRACTPMID:34499025 | DOI:10.1164/rccm.2044P9 (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 9, 2021 Category: Respiratory Medicine Authors: Sarah Neff Matthew G Drake Christopher G Slatore Ellen Burnham Source Type: research

Simulation of Ventilator Allocation in Critically Ill Patients with COVID-19
Am J Respir Crit Care Med. 2021 Sep 9. doi: 10.1164/rccm.202106-1453LE. Online ahead of print.NO ABSTRACTPMID:34499587 | DOI:10.1164/rccm.202106-1453LE (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 9, 2021 Category: Respiratory Medicine Authors: Sivasubramanium V Bhavani Yuan Luo William D Miller Lazaro N Sanchez-Pinto Xuan Han Chengsheng Mao Burhaneddin Sandikci Monica E Peek Craig M Coopersmith Kelly N Michelson William F Parker Source Type: research

Reduced Exercise Capacity in Adults Born Very Low Birth Weight: A Population-Based Cohort Study
Am J Respir Crit Care Med. 2021 Sep 9. doi: 10.1164/rccm.202103-0755OC. Online ahead of print.ABSTRACTRATIONALE: Population-based data regarding the consequences of very low birth weight (VLBW) and bronchopulmonary dysplasia (BPD) on adult exercise capacity is limited.OBJECTIVES: To compare exercise capacity in a national VLBW cohort with term-born controls and explore factors contributing to the differences.METHODS: At 26-30 years of age, 228 VLBW survivors and 100 controls underwent lung function tests, cardiopulmonary exercise testing and assessment of resting cardiac structure/function using echocardiography. Data on s...
Source: American Journal of Respiratory and Critical Care Medicine - September 9, 2021 Category: Respiratory Medicine Authors: Jun Yang Michael J Epton Sarah L Harris John Horwood Rachel A Kingsford Richard Troughton Charlotte Greer Brian A Darlow Source Type: research

Ensuring Access to Albuterol in Schools: From Policy to Implementation. An Official ATS/AANMA/ALA/NASN Policy Statement
Conclusions: Stock albuterol in schools is a safe, practical, and potentially life-saving option for children with asthma, whether asthma is diagnosed or undiagnosed, who lack access to their personal quick-relief medication. Legislation is imperative for aiding in the adoption and implementation of school stock albuterol policies, and key policy inclusions can lay the groundwork for success. Future work should focus on passing legislation in all states, implementing policy in schools, and evaluating the impact of such programs on academic and health outcomes.PMID:34499024 | DOI:10.1164/rccm.202106-1550ST (Source: American...
Source: American Journal of Respiratory and Critical Care Medicine - September 9, 2021 Category: Respiratory Medicine Authors: Anna Volerman Ashley A Lowe Andrea A Pappalardo Charmayne M C Anderson Kathryn V Blake Tyra Bryant-Stephens Thomas Carr Heather Carter Lisa Cicutto Joe K Gerald Tina Miller Nuala S Moore Hanna Phan S Christy Sadreameli Andrea Tanner Tonya A Winders Lynn B Source Type: research

Inhaled Marijuana and the Lungs
Am J Respir Crit Care Med. 2021 Sep 1;204(5):P9-P10. doi: 10.1164/rccm.2044P9.NO ABSTRACTPMID:34499025 | DOI:10.1164/rccm.2044P9 (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 9, 2021 Category: Respiratory Medicine Authors: Sarah Neff Matthew G Drake Christopher G Slatore Ellen Burnham Source Type: research

Simulation of Ventilator Allocation in Critically Ill Patients with COVID-19
Am J Respir Crit Care Med. 2021 Sep 9. doi: 10.1164/rccm.202106-1453LE. Online ahead of print.NO ABSTRACTPMID:34499587 | DOI:10.1164/rccm.202106-1453LE (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 9, 2021 Category: Respiratory Medicine Authors: Sivasubramanium V Bhavani Yuan Luo William D Miller Lazaro N Sanchez-Pinto Xuan Han Chengsheng Mao Burhaneddin Sandikci Monica E Peek Craig M Coopersmith Kelly N Michelson William F Parker Source Type: research

Reduced Exercise Capacity in Adults Born Very Low Birth Weight: A Population-Based Cohort Study
Am J Respir Crit Care Med. 2021 Sep 9. doi: 10.1164/rccm.202103-0755OC. Online ahead of print.ABSTRACTRATIONALE: Population-based data regarding the consequences of very low birth weight (VLBW) and bronchopulmonary dysplasia (BPD) on adult exercise capacity is limited.OBJECTIVES: To compare exercise capacity in a national VLBW cohort with term-born controls and explore factors contributing to the differences.METHODS: At 26-30 years of age, 228 VLBW survivors and 100 controls underwent lung function tests, cardiopulmonary exercise testing and assessment of resting cardiac structure/function using echocardiography. Data on s...
Source: American Journal of Respiratory and Critical Care Medicine - September 9, 2021 Category: Respiratory Medicine Authors: Jun Yang Michael J Epton Sarah L Harris John Horwood Rachel A Kingsford Richard Troughton Charlotte Greer Brian A Darlow Source Type: research

Reply to: Olfactory-nasal Nitric-oxide Link in COVID-19: A Marker of Neurogenesis or Risk Factor for Chronic Rhinosinusitis?
Am J Respir Crit Care Med. 2021 Sep 7. doi: 10.1164/rccm.202108-1827LE. Online ahead of print.NO ABSTRACTPMID:34491870 | DOI:10.1164/rccm.202108-1827LE (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 7, 2021 Category: Respiratory Medicine Authors: Anh Tuan Dinh-Xuan Th ông Hua-Huy all authors of “Persistent Nasal Inflammation 5 Months after Acute Anosmia in Patients with COVID-19” Source Type: research

Olfactory-nasal Nitric-oxide Link in COVID-19: A Marker of Neurogenesis or Risk Factor for Chronic Rhinosinusitis?
Am J Respir Crit Care Med. 2021 Sep 7. doi: 10.1164/rccm.202107-1697LE. Online ahead of print.NO ABSTRACTPMID:34491873 | DOI:10.1164/rccm.202107-1697LE (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 7, 2021 Category: Respiratory Medicine Authors: Amit Jain Source Type: research

Everolimus-Eluting Stent-Induced Pneumonitis
Am J Respir Crit Care Med. 2021 Sep 7. doi: 10.1164/rccm.202103-0565IM. Online ahead of print.NO ABSTRACTPMID:34491881 | DOI:10.1164/rccm.202103-0565IM (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 7, 2021 Category: Respiratory Medicine Authors: Haruki Kobayashi Source Type: research

Transvenous Diaphragm Neurostimulation Mitigates Ventilation-associated Brain Injury
Am J Respir Crit Care Med. 2021 Sep 7. doi: 10.1164/rccm.202101-0076OC. Online ahead of print.ABSTRACTRATIONALE: Mechanical ventilation (MV) is associated with hippocampal apoptosis and inflammation, and it is important to study strategies to mitigate them.OBJECTIVES: Explore whether temporary transvenous diaphragm neurostimulation (TTDN) in association with MV mitigates hippocampal apoptosis and inflammation after 50 hours of MV.METHODS: Normal-lung porcine study comparing apoptotic index, inflammatory markers, and neurological-damage serum markers between never-ventilated subjects, subjects undergoing 50 hours of MV plus...
Source: American Journal of Respiratory and Critical Care Medicine - September 7, 2021 Category: Respiratory Medicine Authors: Thiago G Bassi Elizabeth C Rohrs Karl C Fernandez Marlena Ornoswska Michelle Nicholas Matt Gani Doug Evans Steven C Reynolds Source Type: research

Can N3 Period Duration Serve as a Predictor of Cognitive Dysfunction?
Am J Respir Crit Care Med. 2021 Sep 3. doi: 10.1164/rccm.202105-1231LE. Online ahead of print.NO ABSTRACTPMID:34478349 | DOI:10.1164/rccm.202105-1231LE (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 3, 2021 Category: Respiratory Medicine Authors: Zhenzhen Zheng Riken Chen Cheng Hong Jianmin Lu Chunying Zhuang Haimin Liu Yue Zhong Nuofu Zhang Source Type: research

Reply to: Can N3 Period Duration Serve as a Predictor of Cognitive Dysfunction?
Am J Respir Crit Care Med. 2021 Sep 3. doi: 10.1164/rccm.202106-1414LE. Online ahead of print.NO ABSTRACTPMID:34478350 | DOI:10.1164/rccm.202106-1414LE (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 3, 2021 Category: Respiratory Medicine Authors: Ina E Djonlagic Meng Guo Moroke Igue Divya Kishore Robert Stickgold Atul Malhotra Source Type: research

Obstructive Apneas in a Mouse Model of Congenital Central Hypoventilation Syndrome
Am J Respir Crit Care Med. 2021 Sep 3. doi: 10.1164/rccm.202104-0887OC. Online ahead of print.ABSTRACTRATIONALE: Congenital Central Hypoventilation Syndrome (CCHS) is characterized by life-threatening sleep hypoventilation and is caused by PHOX2B gene mutations, most frequently the PHOX2B27Ala/+ mutation, with patients requiring lifelong ventilatory support. It is unclear whether obstructive apneas are part of the syndrome.OBJECTIVES: To determine if Phox2b27Ala/+ mice, which present the main symptoms of CCHS and die within hours after birth, also express obstructive apneas, and to investigate potential underlying mechanis...
Source: American Journal of Respiratory and Critical Care Medicine - September 3, 2021 Category: Respiratory Medicine Authors: Am élia Madani Gabriel Pitollat El éonore Sizun Laura Cardoit Maud Ringot Thomas Bourgeois Nelina Ramanantsoa Christophe Delclaux St éphane Dauger Marie-Pia d'Ortho Muriel Thoby-Brisson Jorge Gallego Boris Matrot Source Type: research

Epigenomic Landscape, A Cornerstone of Macrophage Phenotype Regulation in the Fibrotic Lung
Am J Respir Crit Care Med. 2021 Sep 3. doi: 10.1164/rccm.202107-1760ED. Online ahead of print.NO ABSTRACTPMID:34478358 | DOI:10.1164/rccm.202107-1760ED (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 3, 2021 Category: Respiratory Medicine Authors: Megan N Ballinger Ana L Mora Source Type: research

Dynamic Metabolic Risk Profiling of World Trade Center-Lung Disease: A Longitudinal Cohort Study
Am J Respir Crit Care Med. 2021 Sep 2. doi: 10.1164/rccm.202006-2617OC. Online ahead of print.ABSTRACTRATIONALE. Metabolic Syndrome (MetSyn) increases the risk of World Trade Center-Lung Injury (WTC-LI). However, the temporal relationship of MetSyn, exposure intensity, and lung dysfunction is not well understood. We modeled the association of longitudinal MetSyn characteristics with WTC-lung disease to define modifiable risk. METHODS. Consented firefighters (N=5,738) were active-duty on 9/11/01 (9/11). WTC-LI (N=1,475; FEV1%predicted
Source: American Journal of Respiratory and Critical Care Medicine - September 2, 2021 Category: Respiratory Medicine Authors: Sophia Kwon Myeonggyun Lee George Crowley Theresa Schwartz Rachel Zeig-Owens David J Prezant Mengling Liu Anna Nolan Source Type: research

Reply to: Pulmonary Hypertension: A Predictor of Lung Cancer Prognosis?
Am J Respir Crit Care Med. 2021 Sep 2. doi: 10.1164/rccm.202106-1411LE. Online ahead of print.NO ABSTRACTPMID:34473933 | DOI:10.1164/rccm.202106-1411LE (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 2, 2021 Category: Respiratory Medicine Authors: Bastian Eul Michael Cekay Soni Savai Pullamsetti Khodr Tello Jochen Wilhelm Stefan Gattenl öhner Ulf Sibelius Friedrich Grimminger Werner Seeger Rajkumar Savai Source Type: research

The Renin-Angiotensin-Aldosterone System in COVID-related and non-COVID-related ARDS: Not So Different After All?
Am J Respir Crit Care Med. 2021 Sep 2. doi: 10.1164/rccm.202108-1904ED. Online ahead of print.NO ABSTRACTPMID:34473935 | DOI:10.1164/rccm.202108-1904ED (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 2, 2021 Category: Respiratory Medicine Authors: Sean P Collins Mark C Chappell D Clark Files Source Type: research

Pulmonary Hypertension: A Predictor of Lung Cancer Prognosis?
Am J Respir Crit Care Med. 2021 Sep 2. doi: 10.1164/rccm.202105-1256LE. Online ahead of print.NO ABSTRACTPMID:34473936 | DOI:10.1164/rccm.202105-1256LE (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 2, 2021 Category: Respiratory Medicine Authors: Zhenzhen Zheng Riken Chen Nuofu Zhang Chunying Zhuang Jianmin Lu Yue Zhong Haimin Liu Cheng Hong Source Type: research

Endobronchial Optical Coherence Tomography for the Diagnosis of Fibrotic ILD: A Light at the End of the Tunnel?
Am J Respir Crit Care Med. 2021 Sep 2. doi: 10.1164/rccm.202108-1899ED. Online ahead of print.NO ABSTRACTPMID:34473937 | DOI:10.1164/rccm.202108-1899ED (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 2, 2021 Category: Respiratory Medicine Authors: Daniel-Costin Marinescu Christopher J Ryerson Source Type: research

Multiomics Analysis Reveals Distinct Immunogenomic Features of Lung Cancer with Ground-Glass Opacity
Conclusions Compared to lung cancers presenting with solid lung nodules, GGO-associated lung cancers are characterized by less active metabolism and immune microenvironment that may be the mechanisms underlying their indolent clinical course.PMID:34473939 | DOI:10.1164/rccm.202101-0119OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 2, 2021 Category: Respiratory Medicine Authors: Kezhong Chen Jing Bai Alexandre Reuben Heng Zhao Guannan Kang Chunliu Zhang Qingyi Qi Yaping Xu Shawna Hubert Lianpeng Chang Yanfang Guan Lin Feng Kai Zhang Kaitai Zhang Xin Yi Xuefeng Xia Shujun Cheng Fan Yang Jianjun Zhang Jun Wang Source Type: research

Pulmonary Innate Lymphoid Cell Responses during Rhinovirus-induced Asthma Exacerbations < em > In Vivo < /em > : A Clinical Trial
Am J Respir Crit Care Med. 2021 Sep 1. doi: 10.1164/rccm.202010-3754OC. Online ahead of print.ABSTRACTRationale Type 2 innate lymphoid cells (ILC2s) are significant sources of type 2 cytokines, which are implicated in the pathogenesis of asthma and asthma exacerbations. The role of ILC2s in virus-induced asthma exacerbations is not well-characterized. Objectives To characterize pulmonary ILC responses following experimental rhinovirus challenge in patients with moderate asthma and healthy subjects. Methods Patients with moderate asthma and healthy subjects were inoculated with rhinovirus-16, and underwent bronchoscopy at b...
Source: American Journal of Respiratory and Critical Care Medicine - September 1, 2021 Category: Respiratory Medicine Authors: Jaideep Dhariwal Aoife Cameron Ernie Wong Malte Paulsen Belen Trujillo-Torralbo Ajerico Del Rosario Eteri Bakhsoliani Tatiana Kebadze Mark Almond Hugo Farne Leila Gogsadze Julia Aniscenko Batika Rana Trevor T Hansel David J Jackson Onn Min Kon Michael R E Source Type: research

Cystic Fibrosis-related Diabetes is Associated with Worse Lung Function Trajectory Despite Ivacaftor Use
Am J Respir Crit Care Med. 2021 Sep 1. doi: 10.1164/rccm.202104-1060LE. Online ahead of print.NO ABSTRACTPMID:34469275 | DOI:10.1164/rccm.202104-1060LE (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 1, 2021 Category: Respiratory Medicine Authors: Charles D Bengtson Jianghua He Michael D Kim Matthias A Salathe Source Type: research

Poor Adherence to Continuous Positive Airway Pressure Hugely Improved During COVID-19 Lockdown in France
Am J Respir Crit Care Med. 2021 Sep 1. doi: 10.1164/rccm.202103-0803LE. Online ahead of print.NO ABSTRACTPMID:34469697 | DOI:10.1164/rccm.202103-0803LE (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 1, 2021 Category: Respiratory Medicine Authors: Jean-Louis P épin Najeh Daabek S ébastien Bailly Renaud Tamisier David Attias Atul Pathak Source Type: research