Rapid influenza molecular testing in secondary care and influenza surveillance in England: Any impact?
CONCLUSIONS: The use of rapid influenza molecular tests is a likely contributing factor to the large proportion of influenza A hospitalisations in England that were unsubtyped. Given their clear clinical advantages, further work must be done to reinforce these data for public health through integrated genomic surveillance.PMID:35585686 | DOI:10.1111/irv.13001 (Source: Respiratory Care)
Source: Respiratory Care - May 19, 2022 Category: Respiratory Medicine Authors: Nicki L Boddington Suzanne Elgohari Joanna Ellis Matthew Donati Maria Zambon Richard G Pebody Source Type: research

CRTH2 Mediates Pro-fibrotic Macrophage Differentiation and Promotes Lung Fibrosis
Am J Respir Cell Mol Biol. 2022 May 18. doi: 10.1165/rcmb.2021-0504OC. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a particularly deadly form of pulmonary fibrosis with unknown reason. In patients with IPF, high serum and lung levels of CHI3L1 can be detected and are associated with poor survival. However, the roles of CHI3L1 in these diseases have not been fully elucidated. We hypothesize that CHI3L1 interacts with CRTH2 to stimulate pro-fibrotic macrophage differentiation and the development of pulmonary fibrosis and that circulating blood monocytes from patients with IPF are hyperresponsive to C...
Source: Respiratory Care - May 19, 2022 Category: Respiratory Medicine Authors: Yueming Cao Jahnavi Rudrakshala River Williams Shade Rodriguez Parand Sorkhdini Alina X Yang Miles Mundy Dongqin Yang Amy Palmisciano Thomas Walsh Cesar Delcompare Tanis Caine Luca Tomasi Barry S Shea Yang Zhou Source Type: research

Effectiveness, nephrotoxicity, and therapeutic drug monitoring of polymyxin B in nosocomial pneumonia among critically ill patients
CONCLUSION: Our findings show that TDM of polymyxin B is a valuable intervention, and the achievement of its optimal pharmacodynamic target can improve treatment outcome. Renal insufficiency and concomitant treatment with loop diuretics were found to be associated with the risk of nephrotoxicity.PMID:35586931 | DOI:10.1111/crj.13493 (Source: Respiratory Care)
Source: Respiratory Care - May 19, 2022 Category: Respiratory Medicine Authors: Qinghua Ye Qianlin Wang Ziying Chen Wenqian Chen Qingyuan Zhan Chen Wang Source Type: research

Balancing the risks and benefits is essential for reaping the success of adding in-circuit bacterial filters
Eur Respir J. 2022 May 19;59(5):2200562. doi: 10.1183/13993003.00562-2022. Print 2022 May.NO ABSTRACTPMID:35589116 | DOI:10.1183/13993003.00562-2022 (Source: Respiratory Care)
Source: Respiratory Care - May 19, 2022 Category: Respiratory Medicine Authors: Sven Stieglitz Mohanchandra Mandal Pradipta Bhakta Antonio M Esquinas Source Type: research

CPAP for Cognition in Sleep Apnea and Mild Cognitive Impairment: A Pilot Randomised Cross-Over Trial
Am J Respir Crit Care Med. 2022 May 18. doi: 10.1164/rccm.202111-2646LE. Online ahead of print.NO ABSTRACTPMID:35584294 | DOI:10.1164/rccm.202111-2646LE (Source: Respiratory Care)
Source: Respiratory Care - May 18, 2022 Category: Respiratory Medicine Authors: Camilla M Hoyos Nathan E Cross Zoe Terpening Angela L D'Rozario Brendon J Yee Haley LaMonica Nathaniel S Marshall Ronald R Grunstein Sharon L Naismith Source Type: research

Diaphragmatic Eventration and Positive Pressure Ventilation
Am J Respir Crit Care Med. 2022 May 18. doi: 10.1164/rccm.202109-2110IM. Online ahead of print.NO ABSTRACTPMID:35584323 | DOI:10.1164/rccm.202109-2110IM (Source: Respiratory Care)
Source: Respiratory Care - May 18, 2022 Category: Respiratory Medicine Authors: Evan B Selzer Kathleen Biblowitz Erika J Yoo Source Type: research

Microbiomics Focused Data Integration: A Fresh Solve for the Rubik's Cube of Endophenotyping?
Am J Respir Crit Care Med. 2022 May 18. doi: 10.1164/rccm.202205-0860ED. Online ahead of print.NO ABSTRACTPMID:35584334 | DOI:10.1164/rccm.202205-0860ED (Source: Respiratory Care)
Source: Respiratory Care - May 18, 2022 Category: Respiratory Medicine Authors: Jayanth Kumar Narayana Krasimira Tsaneva-Atanasova Sanjay H Chotirmall Source Type: research

Reply to: The Need for a CYFRA 21-1 Cut-off Value to Predict Clinical Progression of IPF in Clinical Practice
Am J Respir Crit Care Med. 2022 May 18. doi: 10.1164/rccm.202205-0835LE. Online ahead of print.NO ABSTRACTPMID:35584340 | DOI:10.1164/rccm.202205-0835LE (Source: Respiratory Care)
Source: Respiratory Care - May 18, 2022 Category: Respiratory Medicine Authors: Philip L Molyneaux Toby M Maher authors of “CYFRA 21-1 predicts progression in IPF; a prospective longitudinal analysis of the PROFILE cohort.” Source Type: research

Reduction of Lung Hyperinflation Improves Cardiac Preload, Contractility, and Output in Emphysema: A Prospective Cardiac Magnetic Resonance Study in Patients Who Received Endobronchial Valves
CONCLUSIONS: We found that reduction of hyperinflation using BLVR with endobronchial valves significantly improved cardiac preload, myocardial contractility, and cardiac output, without changes in pulmonary artery pressures. Clinical trial registered with ClinicalTrials.gov (NCT03474471).PMID:35584341 | DOI:10.1164/rccm.202201-0214OC (Source: Respiratory Care)
Source: Respiratory Care - May 18, 2022 Category: Respiratory Medicine Authors: Marieke C van der Molen Jorine E Hartman Lowie E G W Vanfleteren Huib A M Kerstjens Joost P van Melle Tineke P Willems Dirk-Jan Slebos Source Type: research

Aerosolization of < em > Mycobacterium tuberculosis < /em > by Tidal Breathing
CONCLUSIONS: Assuming the number of viable Mtb organisms released offers a reliable proxy of patient infectiousness, our observations imply that TiBr and inter-individual variability in Mtb release might be significant contributors to TB transmission among active cases. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:35584342 | DOI:10.1164/rccm.202110-2378OC (Source: Respiratory Care)
Source: Respiratory Care - May 18, 2022 Category: Respiratory Medicine Authors: Ryan Dinkele Sophia Gessner Andrea McKerry Bryan Leonard Juane Leukes Ronnett Seldon Digby F Warner Robin Wood Source Type: research

The Need for a CYFRA 21-1 Cut-off Value to Predict Clinical Progression of IPF in Clinical Practice
Am J Respir Crit Care Med. 2022 May 18. doi: 10.1164/rccm.202204-0708LE. Online ahead of print.NO ABSTRACTPMID:35584343 | DOI:10.1164/rccm.202204-0708LE (Source: Respiratory Care)
Source: Respiratory Care - May 18, 2022 Category: Respiratory Medicine Authors: Hajime Fujimoto Corina N D'Alessandro-Gabazza Taro Yasuma Tetsu Kobayashi Esteban C Gabazza Source Type: research

Muscle Protein Synthesis Following Protein Administration in Critical Illness
Conclusion The capacity for critically ill patients to use ingested protein for muscle protein synthesis is markedly blunted despite relatively normal protein digestion and amino acid absorption.PMID:35584344 | DOI:10.1164/rccm.202112-2780OC (Source: Respiratory Care)
Source: Respiratory Care - May 18, 2022 Category: Respiratory Medicine Authors: Lee-Anne S Chapple Imre W K Kouw Matthew J Summers Luke M Weinel Samuel Gluck Eamon Raith Peter Slobodian Stijn Soenen Adam M Deane Luc J C van Loon Marianne J Chapman Source Type: research

Double Jeopardy: Precapillary Pulmonary Hypertension Increases the Risk of Hospitalization and Death from COVID-19
Am J Respir Crit Care Med. 2022 May 18. doi: 10.1164/rccm.202205-0884ED. Online ahead of print.NO ABSTRACTPMID:35584345 | DOI:10.1164/rccm.202205-0884ED (Source: Respiratory Care)
Source: Respiratory Care - May 18, 2022 Category: Respiratory Medicine Authors: George A Alba Source Type: research

T2 or non-T2 Asthma Exacerbations: That is the Question
Am J Respir Crit Care Med. 2022 May 18. doi: 10.1164/rccm.202205-0857ED. Online ahead of print.NO ABSTRACTPMID:35584351 | DOI:10.1164/rccm.202205-0857ED (Source: Respiratory Care)
Source: Respiratory Care - May 18, 2022 Category: Respiratory Medicine Authors: Andi Hudler Fernando Holguin Sunita Sharma Source Type: research

< sup > 129 < /sup > Xe MRI ventilation defects in ever-hospitalised and never-hospitalised people with post-acute COVID-19 syndrome
CONCLUSION: 129Xe MRI VDP was significantly worse in ever-hospitalised as compared with never-hospitalised participants and was related to 6MWD and exertional SpO2 but not SGRQ or mMRC scores.TRIAL REGISTRATION NUMBER: NCT05014516.PMID:35584850 | DOI:10.1136/bmjresp-2022-001235 (Source: Respiratory Care)
Source: Respiratory Care - May 18, 2022 Category: Respiratory Medicine Authors: Harkiran K Kooner Marrissa J McIntosh Alexander M Matheson Carmen Venegas Nisarg Radadia Terence Ho Ehsan Ahmed Haider Norman B Konyer Giles E Santyr Mitchell S Albert Alexei Ouriadov Mohamed Abdelrazek Miranda Kirby Inderdeep Dhaliwal J Michael Nicholson Source Type: research