Association of asthma with low serum vitamin D and its related musculoskeletal and psychological symptoms in adults: a case-control study
NPJ Prim Care Respir Med. 2021 May 14;31(1):27. doi: 10.1038/s41533-021-00239-7.ABSTRACTThere are complex potential inter-relationships between the chronic inflammation of asthma and poor control, vitamin D deficiency, musculoskeletal pain and anxiety and depression. The aim was to investigate associations between vitamin D and these possible co-morbidities. This case-controlled study involved 75 adults with asthma and 75 controls. Serum 25-hydroxyvitamin D (25(OH)D) was measured, levels of anxiety, depression, musculoskeletal pain, and asthma control were assessed. Participants with asthma had lower 25(OH)D and higher anx...
Source: Respiratory Care - May 15, 2021 Category: Respiratory Medicine Authors: Mohammad J Alkhatatbeh Haneen S Almomani Khalid K Abdul-Razzak Shaher Samrah Source Type: research

Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: results of a multicenter, randomized, double-blind, parallel-group controlled trial
Respir Res. 2021 May 13;22(1):149. doi: 10.1186/s12931-021-01740-w.ABSTRACTBACKGROUND: To investigate whether the administration of hydrogen/oxygen mixture was superior to oxygen in improving symptoms in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).METHODS: This prospective, randomized, double-blind, controlled clinical trial in 10 centres enrolled patient with AECOPD and a Breathlessness, Cough, and Sputum Scale (BCSS) score of at least 6 points. Eligible patients were randomly assigned (in a 1:1 ratio) to receive either hydrogen/oxygen mixture or oxygen therapy. Primary endpoint was ...
Source: Respiratory Care - May 14, 2021 Category: Respiratory Medicine Authors: Ze-Guang Zheng Wu-Zhuang Sun Jie-Ying Hu Zhi-Jun Jie Jin-Fu Xu Jie Cao Yuan-Lin Song Chang-Hui Wang Jing Wang Hui Zhao Zhong-Liang Guo Nan-Shan Zhong Source Type: research

Socioeconomic biases in asthma control and specialist referral of possible severe asthma
CONCLUSION: Even in settings with nationally available free access to specialist care, the majority of patients with possible severe asthma are managed in primary care. Referral of at-risk asthma patients differs across socioeconomic parameters, calling for initiatives to identify and actively refer these patients.PMID:33986027 | DOI:10.1183/13993003.00741-2021 (Source: Respiratory Care)
Source: Respiratory Care - May 14, 2021 Category: Respiratory Medicine Authors: Kjell Erik Julius H åkansson Vibeke Backer Charlotte Suppli Ulrik Source Type: research

Trends in risk stratification, in-hospital management and mortality of patients with acute pulmonary embolism: an analysis from China pUlmonary thromboembolism REgistry Study (CURES)
Eur Respir J. 2021 May 13:2002963. doi: 10.1183/13993003.02963-2020. Online ahead of print.ABSTRACTBACKGROUND: Similar trends of management and in-hospital mortality of acute pulmonary embolism (PE) have been reported in European and American populations. However, these tendencies were not clear in Asian countries.OBJECTIVES: We retrospectively analyzed the trends of risk stratification, management and in-hospital mortality for patients with acute PE through a multicenter registry in China (CURES).METHODS: Adult patients with acute symptomatic PE were included between 2009 and 2015. Trends in disease diagnosis, treatment a...
Source: Respiratory Care - May 14, 2021 Category: Respiratory Medicine Authors: Zhenguo Zhai Dingyi Wang Jieping Lei Yuanhua Yang Xiaomao Xu Yingqun Ji Qun Yi Hong Chen Xiaoyun Hu Zhihong Liu Yimin Mao Jie Zhang Juhong Shi Zhu Zhang Sinan Wu Qian Gao Xincao Tao Wanmu Xie Jun Wan Yunxia Zhang Shuai Zhang Kaiyuan Zhen Zhonghe Zhang Bao Source Type: research

Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: results of a multicenter, randomized, double-blind, parallel-group controlled trial
Respir Res. 2021 May 13;22(1):149. doi: 10.1186/s12931-021-01740-w.ABSTRACTBACKGROUND: To investigate whether the administration of hydrogen/oxygen mixture was superior to oxygen in improving symptoms in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).METHODS: This prospective, randomized, double-blind, controlled clinical trial in 10 centres enrolled patient with AECOPD and a Breathlessness, Cough, and Sputum Scale (BCSS) score of at least 6 points. Eligible patients were randomly assigned (in a 1:1 ratio) to receive either hydrogen/oxygen mixture or oxygen therapy. Primary endpoint was ...
Source: Respiratory Care - May 14, 2021 Category: Respiratory Medicine Authors: Ze-Guang Zheng Wu-Zhuang Sun Jie-Ying Hu Zhi-Jun Jie Jin-Fu Xu Jie Cao Yuan-Lin Song Chang-Hui Wang Jing Wang Hui Zhao Zhong-Liang Guo Nan-Shan Zhong Source Type: research

Socioeconomic biases in asthma control and specialist referral of possible severe asthma
CONCLUSION: Even in settings with nationally available free access to specialist care, the majority of patients with possible severe asthma are managed in primary care. Referral of at-risk asthma patients differs across socioeconomic parameters, calling for initiatives to identify and actively refer these patients.PMID:33986027 | DOI:10.1183/13993003.00741-2021 (Source: Respiratory Care)
Source: Respiratory Care - May 14, 2021 Category: Respiratory Medicine Authors: Kjell Erik Julius H åkansson Vibeke Backer Charlotte Suppli Ulrik Source Type: research

Trends in risk stratification, in-hospital management and mortality of patients with acute pulmonary embolism: an analysis from China pUlmonary thromboembolism REgistry Study (CURES)
Eur Respir J. 2021 May 13:2002963. doi: 10.1183/13993003.02963-2020. Online ahead of print.ABSTRACTBACKGROUND: Similar trends of management and in-hospital mortality of acute pulmonary embolism (PE) have been reported in European and American populations. However, these tendencies were not clear in Asian countries.OBJECTIVES: We retrospectively analyzed the trends of risk stratification, management and in-hospital mortality for patients with acute PE through a multicenter registry in China (CURES).METHODS: Adult patients with acute symptomatic PE were included between 2009 and 2015. Trends in disease diagnosis, treatment a...
Source: Respiratory Care - May 14, 2021 Category: Respiratory Medicine Authors: Zhenguo Zhai Dingyi Wang Jieping Lei Yuanhua Yang Xiaomao Xu Yingqun Ji Qun Yi Hong Chen Xiaoyun Hu Zhihong Liu Yimin Mao Jie Zhang Juhong Shi Zhu Zhang Sinan Wu Qian Gao Xincao Tao Wanmu Xie Jun Wan Yunxia Zhang Shuai Zhang Kaiyuan Zhen Zhonghe Zhang Bao Source Type: research

Comparison of clinical and radiologic characteristics between anthracofibrosis and endobronchial lung cancer
CONCLUSION: Our study demonstrated the characteristic of clinical radiologic findings in AF and endobronchial lung cancer. Increasing the awareness of both diseases may help clinicians to differentiate the diseases from each other, avoiding unnecessary invasive diagnostic procedures.PMID:33979986 | DOI:10.4046/trd.2020.0159 (Source: Respiratory Care)
Source: Respiratory Care - May 13, 2021 Category: Respiratory Medicine Authors: Seo Young Yun Tae Yun Park Source Type: research

Diagnostic accuracy of the Quidel Sofia rapid influenza fluorescent immunoassay in patients with influenza-like illness: A systematic review and meta-analysis
CONCLUSIONS: The pooled sensitivities of the Quidel Sofia rapid influenza FIA did not quite meet the target level (≥80%) for both influenza A and B. The interpretation of data should be carefully considered due to substantial between-study heterogeneity.PMID:33979987 | DOI:10.4046/trd.2021.0033 (Source: Respiratory Care)
Source: Respiratory Care - May 13, 2021 Category: Respiratory Medicine Authors: Jonghoo Lee Jae-Uk Song Yee Hyung Kim Source Type: research

Revised Korean Cough Guidelines, 2020: Recommendations and Summary statements
This article highlights the recommendations and summary of the revised Korean cough guidelines. It includes a revised algorithm for the evaluation of acute, subacute, and chronic cough. For chronic cough, upper airway cough syndrome (UACS), cough variant asthma (CVA), and gastroesophageal reflux disease (GERD) should be considered in the differential diagnoses. If UACS is suspected, first-generation antihistamines and nasal decongestants can be used empirically. In cases with CVA, inhaled corticosteroids are recommended to improve the cough. In patients with suspected chronic cough due to symptomatic GERD, proton pump inhi...
Source: Respiratory Care - May 13, 2021 Category: Respiratory Medicine Authors: Hyonsoo Joo Ji-Yong Moon Tai Joon An Hayoung Choi So Young Park Hongseok Yoo Chi Young Kim Ina Jeong Joo-Hee Kim Hyeon-Kyoung Koo Chin Kook Rhee Sei Won Lee Sung Kyoung Kim Kyung Hoon Min Yee Hyung Kim Seung Hun Jang Deog Kyeom Kim Jong Wook Shin Hyoung K Source Type: research

Is COVID-19 Masking the Ongoing Youth Vaping Crisis?
Expert Rev Respir Med. 2021 May 12. doi: 10.1080/17476348.2021.1929927. Online ahead of print.NO ABSTRACTPMID:33980122 | DOI:10.1080/17476348.2021.1929927 (Source: Respiratory Care)
Source: Respiratory Care - May 13, 2021 Category: Respiratory Medicine Authors: Sean J Callahan Michael J Lanspa Denitza P Blagev Source Type: research

Characteristics and treatable traits of patients with chronic obstructive pulmonary disease (COPD) with and without paid employment
Respir Res. 2021 May 12;22(1):147. doi: 10.1186/s12931-021-01736-6.ABSTRACTINTRODUCTION: Patients with COPD are vulnerable to workforce detachment. Better knowledge of features associated with paid work loss might be of help to design and select appropriate interventions.METHOD: This cross-sectional study aimed to explore the presence of treatable traits in COPD patients without paid work. Patients with COPD below 65 years at first referral to a hospital-based patient clinic were included. Using binary logistic regression analysis, the relationship between paid work and the following characteristics was explored: low daily...
Source: Respiratory Care - May 13, 2021 Category: Respiratory Medicine Authors: Peter A Jacobsen Alex J van 't Hul Remco S Djamin Jeanine C Antons Marianne de Man Ulla M øller Weinreich Martijn A Spruit Daisy J A Janssen Source Type: research

Comparison of clinical and radiologic characteristics between anthracofibrosis and endobronchial lung cancer
CONCLUSION: Our study demonstrated the characteristic of clinical radiologic findings in AF and endobronchial lung cancer. Increasing the awareness of both diseases may help clinicians to differentiate the diseases from each other, avoiding unnecessary invasive diagnostic procedures.PMID:33979986 | DOI:10.4046/trd.2020.0159 (Source: Respiratory Care)
Source: Respiratory Care - May 13, 2021 Category: Respiratory Medicine Authors: Seo Young Yun Tae Yun Park Source Type: research

Diagnostic accuracy of the Quidel Sofia rapid influenza fluorescent immunoassay in patients with influenza-like illness: A systematic review and meta-analysis
CONCLUSIONS: The pooled sensitivities of the Quidel Sofia rapid influenza FIA did not quite meet the target level (≥80%) for both influenza A and B. The interpretation of data should be carefully considered due to substantial between-study heterogeneity.PMID:33979987 | DOI:10.4046/trd.2021.0033 (Source: Respiratory Care)
Source: Respiratory Care - May 13, 2021 Category: Respiratory Medicine Authors: Jonghoo Lee Jae-Uk Song Yee Hyung Kim Source Type: research

Revised Korean Cough Guidelines, 2020: Recommendations and Summary statements
This article highlights the recommendations and summary of the revised Korean cough guidelines. It includes a revised algorithm for the evaluation of acute, subacute, and chronic cough. For chronic cough, upper airway cough syndrome (UACS), cough variant asthma (CVA), and gastroesophageal reflux disease (GERD) should be considered in the differential diagnoses. If UACS is suspected, first-generation antihistamines and nasal decongestants can be used empirically. In cases with CVA, inhaled corticosteroids are recommended to improve the cough. In patients with suspected chronic cough due to symptomatic GERD, proton pump inhi...
Source: Respiratory Care - May 13, 2021 Category: Respiratory Medicine Authors: Hyonsoo Joo Ji-Yong Moon Tai Joon An Hayoung Choi So Young Park Hongseok Yoo Chi Young Kim Ina Jeong Joo-Hee Kim Hyeon-Kyoung Koo Chin Kook Rhee Sei Won Lee Sung Kyoung Kim Kyung Hoon Min Yee Hyung Kim Seung Hun Jang Deog Kyeom Kim Jong Wook Shin Hyoung K Source Type: research

Is COVID-19 Masking the Ongoing Youth Vaping Crisis?
Expert Rev Respir Med. 2021 May 12. doi: 10.1080/17476348.2021.1929927. Online ahead of print.NO ABSTRACTPMID:33980122 | DOI:10.1080/17476348.2021.1929927 (Source: Respiratory Care)
Source: Respiratory Care - May 13, 2021 Category: Respiratory Medicine Authors: Sean J Callahan Michael J Lanspa Denitza P Blagev Source Type: research

Characteristics and treatable traits of patients with chronic obstructive pulmonary disease (COPD) with and without paid employment
Respir Res. 2021 May 12;22(1):147. doi: 10.1186/s12931-021-01736-6.ABSTRACTINTRODUCTION: Patients with COPD are vulnerable to workforce detachment. Better knowledge of features associated with paid work loss might be of help to design and select appropriate interventions.METHOD: This cross-sectional study aimed to explore the presence of treatable traits in COPD patients without paid work. Patients with COPD below 65 years at first referral to a hospital-based patient clinic were included. Using binary logistic regression analysis, the relationship between paid work and the following characteristics was explored: low daily...
Source: Respiratory Care - May 13, 2021 Category: Respiratory Medicine Authors: Peter A Jacobsen Alex J van 't Hul Remco S Djamin Jeanine C Antons Marianne de Man Ulla M øller Weinreich Martijn A Spruit Daisy J A Janssen Source Type: research

Associations between Inhaled Corticosteroid in the First 6 Years of Life and Obesity Related Traits
Conclusions ICS use in early childhood was associated with increased BMI z-score at age six, an earlier adiposity rebound and a trend of association with increased android body fat percentage.PMID:33975528 | DOI:10.1164/rccm.202009-3537OC (Source: Respiratory Care)
Source: Respiratory Care - May 12, 2021 Category: Respiratory Medicine Authors: Asja Kun øe Astrid Sevelsted Bo L Chawes Jakob Stokholm Anders Eliasen Martin Krakauer Klaus B ønnelykke Hans Bisgaard Source Type: research

Adverse Health Effects in People with and without Pre-Existing Respiratory Conditions During Bushfire Smoke Exposure in the 2019/20 Australian Summer
Am J Respir Crit Care Med. 2021 May 11. doi: 10.1164/rccm.202012-4471LE. Online ahead of print.NO ABSTRACTPMID:33975534 | DOI:10.1164/rccm.202012-4471LE (Source: Respiratory Care)
Source: Respiratory Care - May 12, 2021 Category: Respiratory Medicine Authors: C Raina MacIntyre Phi-Yen Nguyen Mallory Trent Holly Seale Abrar Ahmad Chughtai Smita Shah Guy B Marks Source Type: research

Decreasing Unplanned Extubations in the Neonatal ICU
CONCLUSIONS: Development of a quality improvement project by a multidisciplinary taskforce, along with several PDSA cycles including education and staff awareness, reduced the UE rate by 84% in a level 4 NICU. Ongoing surveillance, education, and review of UE cases will be key to maintaining UE events at a goal of 1 UE/100 ventilator days.PMID:33975898 | DOI:10.4187/respcare.08203 (Source: Respiratory Care)
Source: Respiratory Care - May 12, 2021 Category: Respiratory Medicine Authors: Deborah A Igo Kimberly M Kingsley Elisabeth M Malaspina Alan P Picarillo Source Type: research

Long-Term Domiciliary Noninvasive Ventilation for COPD
Respir Care. 2021 May 11:respcare.09052. doi: 10.4187/respcare.09052. Online ahead of print.ABSTRACTCOPD can lead to abnormalities in oxygenation as well as ventilation. Thanks to pioneering work by Dr Thomas Petty, supplemental oxygen therapy has been shown to improve morbidity and mortality for individuals with COPD and severe daytime hypoxemia. However, efforts to augment ventilation have been less uniformly successful. Recent studies employing a so-called high-intensity noninvasive ventilation strategy, which used high inspiratory pressures and backup breathing frequency to reduce arterial carbon dioxide levels, have s...
Source: Respiratory Care - May 12, 2021 Category: Respiratory Medicine Authors: Robert L Owens Source Type: research

A Comparison of the Braden Q and the Braden QD Scale to Assess Pediatric Risk for Pressure Injuries During Noninvasive Ventilation
Respir Care. 2021 May 11:respcare.08536. doi: 10.4187/respcare.08536. Online ahead of print.ABSTRACTBACKGROUND: Noninvasive ventilation (NIV) masks are implicated in 59% of respiratory device-related pressure injuries in hospitalized children. Historically, the Braden Q scale was not adequate in identifying risk for pressure injury associated with devices and, therefore, was modified to the Braden QD scale. The purpose of this study was to evaluate whether the Braden QD scoring tool is better able to identify pediatric patients receiving NIV who are at risk for the development of pressure injury as compared to the previous...
Source: Respiratory Care - May 12, 2021 Category: Respiratory Medicine Authors: Denise L Lauderbaugh Glenn Billman Toni L Popien Shelley Hauseur Euyhyun Lee Judith O'Haver Source Type: research

Effect of Recruitment Maneuvers and PEEP on Respiratory Failure After Cardiothoracic Surgery in Obese Subjects: A Randomized Controlled Trial
CONCLUSIONS: The routine use after heart surgery of a recruitment maneuver followed by 5 or 10 cm H2O of PEEP did not decrease the frequency of respiratory failure in obese subjects. A recruitment maneuver followed by 5 cm H2O of PEEP is inappropriate.PMID:33975901 | DOI:10.4187/respcare.08607 (Source: Respiratory Care)
Source: Respiratory Care - May 12, 2021 Category: Respiratory Medicine Authors: Priscilla Amaru Bertrand Delannoy Thibaut Genty Olivier Desebbe Florent Laverdure Saida Rezaiguia-Delclaux Fran çois Stéphan Source Type: research

High-Flow Nasal Cannula in Pediatric Critical Asthma
Respir Care. 2021 May 11:respcare.08740. doi: 10.4187/respcare.08740. Online ahead of print.ABSTRACTBACKGROUND: High-flow nasal cannula (HFNC) has been used in the treatment of pediatric asthma, although high-quality data comparing HFNC to aerosol mask nebulizer are lacking. We hypothesized that HFNC would perform similarly to the aerosol mask for meaningful clinical outcomes in children with critical asthma.METHODS: We retrospectively reviewed the medical records of children with critical asthma (age 2-17 y) with a modified pulmonary index score (MPIS) ≥ 8 admitted to our pediatric ICU as part of a quality improvement ...
Source: Respiratory Care - May 12, 2021 Category: Respiratory Medicine Authors: Rachel M Gates Kaitlyn E Haynes Kyle J Rehder Kanecia O Zimmerman Alexandre T Rotta Andrew G Miller Source Type: research

Effects of Continuous Positive Airway Pressure on Sleep EEG Characteristics in Patients with Primary Central Sleep Apnea Syndrome
This study aimed to investigate the effects of continuous positive airway pressure (CPAP) on the electroencephalographic (EEG) characteristics of patients with primary central sleep apnea syndrome (CSAS). Nine patients with primary CSAS were enrolled in this study. The raw sleep EEG data were analyzed based on two main factors: fractal dimension (FD) and zero-crossing rate of detrended FD. Additionally, conventional EEG spectral analysis in the delta, theta, alpha, and beta bands was conducted using a fast Fourier transform. The FD in patients with primary CSAS who underwent CPAP treatment was significantly decreased durin...
Source: Respiratory Care - May 12, 2021 Category: Respiratory Medicine Authors: Cheng Zhang Kun Chen Guangfa Wang Jue Zhang Jing Ma Source Type: research

Benefit of switching to mepolizumab from omalizumab in severe eosinophilic asthma based on patient characteristics
CONCLUSIONS: After switching to mepolizumab, almost all patients with uncontrolled severe eosinophilic asthma on omalizumab achieved a beneficial response in ≥ 1 clinical outcome. Improvements were observed regardless of baseline characteristics. Trial registration This manuscript is a post hoc analysis of data from the OSMO study. ClinicalTrials.gov, NCT02654145. Registered January 13, 2016.PMID:33971856 | PMC:PMC8111733 | DOI:10.1186/s12931-021-01733-9 (Source: Respiratory Care)
Source: Respiratory Care - May 11, 2021 Category: Respiratory Medicine Authors: Mark C Liu Bradley Chipps Xavier Munoz Gilles Devouassoux Miguel Bergna Steven G Smith Robert G Price Dmitry V Galkin Jay Azmi Dalal Mouneimne Frank C Albers Kenneth R Chapman Source Type: research

The year in review: mechanical ventilation during the first year of the covid-19 pandemic
Respir Care. 2021 May 10:respcare.09257. doi: 10.4187/respcare.09257. Online ahead of print.ABSTRACTCorona virus disease 2019 (COVID-19) represents the greatest medical crisis encountered in the young history of critical care and respiratory care. During the early months of the pandemic, when little was known about the virus, the acute hypoxemic respiratory failure it caused did not appear to fit conveniently or consistently into our classification of acute respiratory distress syndrome (ARDS). This not only re-ignited a half-century's long simmering debate over taxonomy, but also fueled similar debates over how PEEP and l...
Source: Respiratory Care - May 11, 2021 Category: Respiratory Medicine Authors: Richard H Kallet Source Type: research

Outpatient prescribing pattern for acute bronchitis in primary healthcare settings in China
NPJ Prim Care Respir Med. 2021 May 10;31(1):24. doi: 10.1038/s41533-021-00234-y.ABSTRACTInappropriate prescribing for acute bronchitis in primary healthcare settings (PHSs) is commonly seen worldwide. Here we describe the prescribing patterns and antibiotic use for acute bronchitis in PHSs across China. We conduct a nationwide cross-sectional survey to collect outpatient prescriptions from PHSs in 2017. Patients diagnosed with acute bronchitis without other infections are eligible for this study. Generalized estimating equations are used for analysis. Overall, 10,678 prescriptions for acute bronchitis from 214 institutions...
Source: Respiratory Care - May 11, 2021 Category: Respiratory Medicine Authors: Mengyuan Fu Haishaerjiang Wushouer Lin Hu Nan Li Xiaodong Guan Luwen Shi Dennis Ross-Degnan Source Type: research

Cutting through complexity: the Breathing, Thinking, Functioning clinical model is an educational tool that facilitates chronic breathlessness management
NPJ Prim Care Respir Med. 2021 May 10;31(1):25. doi: 10.1038/s41533-021-00237-9.ABSTRACTChronic breathlessness is a distressing symptom that is challenging to manage. The Breathing, Thinking, Functioning clinical model is an educational tool developed to support breathlessness management. Health professionals report that the model increases clinician and patient understanding of this complex symptom, and provides a simple and structured approach to personalised self-management.PMID:33972569 | PMC:PMC8110567 | DOI:10.1038/s41533-021-00237-9 (Source: Respiratory Care)
Source: Respiratory Care - May 11, 2021 Category: Respiratory Medicine Authors: Anna Spathis Julie Burkin Catherine Moffat Rachel Tuffnell Stephen Barclay Jonathan Mant Sara Booth Source Type: research

Benefit of switching to mepolizumab from omalizumab in severe eosinophilic asthma based on patient characteristics
CONCLUSIONS: After switching to mepolizumab, almost all patients with uncontrolled severe eosinophilic asthma on omalizumab achieved a beneficial response in ≥ 1 clinical outcome. Improvements were observed regardless of baseline characteristics. Trial registration This manuscript is a post hoc analysis of data from the OSMO study. ClinicalTrials.gov, NCT02654145. Registered January 13, 2016.PMID:33971856 | DOI:10.1186/s12931-021-01733-9 (Source: Respiratory Care)
Source: Respiratory Care - May 11, 2021 Category: Respiratory Medicine Authors: Mark C Liu Bradley Chipps Xavier Munoz Gilles Devouassoux Miguel Bergna Steven G Smith Robert G Price Dmitry V Galkin Jay Azmi Dalal Mouneimne Frank C Albers Kenneth R Chapman Source Type: research

The year in review: mechanical ventilation during the first year of the covid-19 pandemic
Respir Care. 2021 May 10:respcare.09257. doi: 10.4187/respcare.09257. Online ahead of print.ABSTRACTCorona virus disease 2019 (COVID-19) represents the greatest medical crisis encountered in the young history of critical care and respiratory care. During the early months of the pandemic, when little was known about the virus, the acute hypoxemic respiratory failure it caused did not appear to fit conveniently or consistently into our classification of acute respiratory distress syndrome (ARDS). This not only re-ignited a half-century's long simmering debate over taxonomy, but also fueled similar debates over how PEEP and l...
Source: Respiratory Care - May 11, 2021 Category: Respiratory Medicine Authors: Richard H Kallet Source Type: research

Outpatient prescribing pattern for acute bronchitis in primary healthcare settings in China
NPJ Prim Care Respir Med. 2021 May 10;31(1):24. doi: 10.1038/s41533-021-00234-y.ABSTRACTInappropriate prescribing for acute bronchitis in primary healthcare settings (PHSs) is commonly seen worldwide. Here we describe the prescribing patterns and antibiotic use for acute bronchitis in PHSs across China. We conduct a nationwide cross-sectional survey to collect outpatient prescriptions from PHSs in 2017. Patients diagnosed with acute bronchitis without other infections are eligible for this study. Generalized estimating equations are used for analysis. Overall, 10,678 prescriptions for acute bronchitis from 214 institutions...
Source: Respiratory Care - May 11, 2021 Category: Respiratory Medicine Authors: Mengyuan Fu Haishaerjiang Wushouer Lin Hu Nan Li Xiaodong Guan Luwen Shi Dennis Ross-Degnan Source Type: research

Cutting through complexity: the Breathing, Thinking, Functioning clinical model is an educational tool that facilitates chronic breathlessness management
NPJ Prim Care Respir Med. 2021 May 10;31(1):25. doi: 10.1038/s41533-021-00237-9.ABSTRACTChronic breathlessness is a distressing symptom that is challenging to manage. The Breathing, Thinking, Functioning clinical model is an educational tool developed to support breathlessness management. Health professionals report that the model increases clinician and patient understanding of this complex symptom, and provides a simple and structured approach to personalised self-management.PMID:33972569 | DOI:10.1038/s41533-021-00237-9 (Source: Respiratory Care)
Source: Respiratory Care - May 11, 2021 Category: Respiratory Medicine Authors: Anna Spathis Julie Burkin Catherine Moffat Rachel Tuffnell Stephen Barclay Jonathan Mant Sara Booth Source Type: research

Genetic Variants of SARS-CoV-2: What do we know so far?
Am J Respir Crit Care Med. 2021 May 10. doi: 10.1164/rccm.2021C5. Online ahead of print.NO ABSTRACTPMID:33970826 | DOI:10.1164/rccm.2021C5 (Source: Respiratory Care)
Source: Respiratory Care - May 10, 2021 Category: Respiratory Medicine Authors: Shazia Jamil Shirin Shafazand Susan Pasnick W Graham Carlos Ryan Maves Charles Dela Cruz Source Type: research

Racial Segregation and Respiratory Outcomes among Urban Black Residents with and at Risk of COPD
CONCLUSIONS: Racial residential segregation was adversely associated with COPD morbidity among urban Black participants and supports the hypothesis that racial segregation plays a role in explaining health inequities affecting Black communities.PMID:33971109 | DOI:10.1164/rccm.202009-3721OC (Source: Respiratory Care)
Source: Respiratory Care - May 10, 2021 Category: Respiratory Medicine Authors: Han Woo Emily P Brigham Kassandra Allbright Chinedu Ejike Panagis Galiatsatos Miranda R Jones Gabriela R Oates Jerry A Krishnan Christopher B Cooper Richard E Kanner Russell P Bowler Eric A Hoffman Alejandro P Comellas Gerard Criner R Graham Barr Fernando Source Type: research

Systemic Air Embolism and Mediastinal Emphysema After Pneumonia
Am J Respir Crit Care Med. 2021 May 10. doi: 10.1164/rccm.202002-0266IM. Online ahead of print.NO ABSTRACTPMID:33971112 | DOI:10.1164/rccm.202002-0266IM (Source: Respiratory Care)
Source: Respiratory Care - May 10, 2021 Category: Respiratory Medicine Authors: Sho Takuma Hideki Kusagaya Shogo Nakuamura Rie Mori Yoshiyuki Oyama Masaki Ikeda Takafumi Suda Source Type: research

The inflammatory profile of exacerbations in patients with severe refractory eosinophilic asthma receiving mepolizumab (the MEX study): a prospective observational study
This study is registered with ClinicalTrials.gov, NCT03324230.FINDINGS: Between Nov 30, 2017, and May 29, 2019, 145 participants were enrolled and treated with mepolizumab, five were excluded from the analysis. 172 exacerbations occurred, with 96 (56%) assessed before commencing rescue treatment. Compared with patients who did not exacerbate, patients who exacerbated had a higher exacerbation rate and more emergency department attendances in the year before commencing mepolizumab. The change in peak expiratory flow at nadir in the assessed exacerbation group was mean -40·5 L/min (SD 76·3) versus mean -37&midd...
Source: Respiratory Care - May 10, 2021 Category: Respiratory Medicine Authors: P Jane McDowell Sarah Diver Freda Yang Catherine Borg John Busby Vanessa Brown Rahul Shrimanker Ciara Cox Christopher E Brightling Rekha Chaudhuri Ian D Pavord Liam G Heaney Medical Research Council: Refractory Asthma Stratification Programme (RASP-UK Con Source Type: research

The combination of intermittent electrical stimulation with acute intermittent hypoxia strengthens genioglossus muscle discharge in chronic intermittent hypoxia-pretreated rats
CONCLUSION: Intermittent electrical stimulation combined with AIH strengthens the genioglossus plasticity in CIH-pretreated rats.PMID:33971311 | DOI:10.1016/j.resp.2021.103680 (Source: Respiratory Care)
Source: Respiratory Care - May 10, 2021 Category: Respiratory Medicine Authors: Huaheng Mo JingJing Zhao Xiaofeng Wu Wei Liu Ke Hu Source Type: research

Pneumonia severity indices predict prognosis in coronavirus disease-2019
CONCLUSION: Community-acquired pneumonia (CAP) scores can predict in COVID-19. The indices proposed specifically to COVID-19 work less than nonspecific scoring systems surprisingly. The CALL score may be used to decide outpatient management in COVID-19.PMID:33971434 | DOI:10.1016/j.resmer.2021.100826 (Source: Respiratory Care)
Source: Respiratory Care - May 10, 2021 Category: Respiratory Medicine Authors: E S Ucan A Ozgen Alpaydin S S Ozuygur S Ercan B Unal A A Sayiner B Ergan N Gokmen Y Savran O Kilinc V Avkan Oguz DEU COVID Study Group Source Type: research

Genetic Variants of SARS-CoV-2: What do we know so far?
Am J Respir Crit Care Med. 2021 May 10. doi: 10.1164/rccm.2021C5. Online ahead of print.NO ABSTRACTPMID:33970826 | DOI:10.1164/rccm.2021C5 (Source: Respiratory Care)
Source: Respiratory Care - May 10, 2021 Category: Respiratory Medicine Authors: Shazia Jamil Shirin Shafazand Susan Pasnick W Graham Carlos Ryan Maves Charles Dela Cruz Source Type: research

Long-term safety of lumacaftor-ivacaftor in children aged 2-5 years with cystic fibrosis homozygous for the F508del-CFTR mutation: a multicentre, phase 3, open-label, extension study
This study is registered with ClinicalTrials.gov, NCT03125395.FINDINGS: This extension study ran from May 12, 2017, to July 17, 2019. Of 60 participants enrolled and who received lumacaftor-ivacaftor in study 115, 57 (95%) were included in study 116 and continued to receive the study drug. A total of 47 (82%) of 57 participants completed 96 weeks of treatment. Most participants (56 [98%] of 57) had at least one adverse event during study 116, most of which were mild (19 [33%] participants) or moderate (29 [51%] participants) in severity. The most common adverse events were cough (47 [82%] participants), nasal congestion (2...
Source: Respiratory Care - May 9, 2021 Category: Respiratory Medicine Authors: Jordana E Hoppe Mark Chilvers Felix Ratjen John J McNamara Caroline A Owen Simon Tian Rachel Zahigian Alexandra G Cornell Susanna A McColley Source Type: research

Combination CFTR modulator therapy in children and adults with cystic fibrosis
Lancet Respir Med. 2021 May 6:S2213-2600(21)00176-4. doi: 10.1016/S2213-2600(21)00176-4. Online ahead of print.NO ABSTRACTPMID:33965001 | DOI:10.1016/S2213-2600(21)00176-4 (Source: Respiratory Care)
Source: Respiratory Care - May 9, 2021 Category: Respiratory Medicine Authors: Jennifer S Guimbellot Jennifer L Taylor-Cousar Source Type: research

The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity
Lancet Respir Med. 2021 May 6:S2213-2600(21)00218-6. doi: 10.1016/S2213-2600(21)00218-6. Online ahead of print.ABSTRACTThe zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with devastating consequences. While the medical community has gained insight into the epidemiology of COVID-19, important questions remain about the clinical complexities and underlying mechanisms of disease phenotypes. Severe COVID-19 most commonly involves respiratory manifestations, although other systems are also affected, and acute disease is often followed by protracted complications. Such complex manifestations sugges...
Source: Respiratory Care - May 9, 2021 Category: Respiratory Medicine Authors: Marcin F Osuchowski Martin S Winkler Tomasz Skirecki Sara Cajander Manu Shankar-Hari Gunnar Lachmann Guillaume Monneret Fabienne Venet Michael Bauer Frank M Brunkhorst Sebastian Weis Alberto Garcia-Salido Matthijs Kox Jean-Marc Cavaillon Florian Uhle Mark Source Type: research

A clinical profile and factors associated with severity of the disease among Polish patients hospitalized due to COVID-19 - an observational study
CONCLUSION: This observational study showed that almost half of hospitalized patients with COVID-19 developed respiratory failure in the course of the disease. Increasing age, BMI, MEWS, d-dimer value and LDH concentration were associated with the severity of COVID-19.PMID:33966260 | DOI:10.5603/ARM.a2021.0035 (Source: Respiratory Care)
Source: Respiratory Care - May 9, 2021 Category: Respiratory Medicine Authors: Tomasz Stachura Natalia Celejewska-W ójcik Kamil Polok Karolina G órka Sabina Licho łai Krzysztof W ójcik Jacek Krawczyk Anna Koz łowska Marek Przybyszowski Tomasz W łoch Jacek G órka Krzysztof S ładek Source Type: research

Predictors of mortality in patients with severe COVID-19 pneumonia - a retrospective study
CONCLUSION: Severe COVID-19 pneumonia is associated with very high mortality, especially in a resource-constrained setting. The use of remdesivir may have to be considered early in the course of disease to prevent excess mortality related to COVID-19.PMID:33966261 | DOI:10.5603/ARM.a2021.0036 (Source: Respiratory Care)
Source: Respiratory Care - May 9, 2021 Category: Respiratory Medicine Authors: M Mahendra Abhishek Nuchin Ranjith Kumar S Shreedhar Padukudru Anand Mahesh Source Type: research

Antiviral treatment selection for SARS-CoV-2 pneumonia
Expert Rev Respir Med. 2021 May 7. doi: 10.1080/17476348.2021.1927719. Online ahead of print.ABSTRACTINTRODUCTION: Therapy of coronavirus disease 2019 (COVID-19) involves evolving algorithms that include drugs aimed at reducing disease progression by counteracting two different, but intertwined processes: (i) the damage caused by the virus (with antivirals); (ii) the damage caused by a dysregulated host response (with immunomodulatory agents).AREAS COVERED: Herein, we discuss the available evidence on efficacy and safety of antiviral agents employed over the past months for the treatment of COVID-19, and the reasons to be ...
Source: Respiratory Care - May 8, 2021 Category: Respiratory Medicine Authors: Matteo Bassetti Silvia Corcione Silvia Dettori Andrea Lombardi Tommaso Lupia Antonio Vena Francesco Giuseppe De Rosa Andrea Gori Daniele Roberto Giacobbe Source Type: research

Pulmonary function testing in COPD: looking beyond the curtain of FEV1
NPJ Prim Care Respir Med. 2021 May 7;31(1):23. doi: 10.1038/s41533-021-00236-w.ABSTRACTChronic obstructive pulmonary disease (COPD) management remains challenging due to the high heterogeneity of clinical symptoms and the complex pathophysiological basis of the disease. Airflow limitation, diagnosed by spirometry, remains the cornerstone of the diagnosis. However, the calculation of the forced expiratory volume in the first second (FEV1) alone, has limitations in uncovering the underlying complexity of the disease. Incorporating additional pulmonary function tests (PFTs) in the everyday clinical evaluation of COPD patients...
Source: Respiratory Care - May 8, 2021 Category: Respiratory Medicine Authors: Sotirios Kakavas Ourania S Kotsiou Fotis Perlikos Maria Mermiri Georgios Mavrovounis Konstantinos Gourgoulianis Ioannis Pantazopoulos Source Type: research

3-month, 6-month, 9-month, and 12-month respiratory outcomes in patients following COVID-19-related hospitalisation: a prospective study
Lancet Respir Med. 2021 May 5:S2213-2600(21)00174-0. doi: 10.1016/S2213-2600(21)00174-0. Online ahead of print.ABSTRACTBACKGROUND: The consequences of COVID-19 in those who recover from acute infection requiring hospitalisation have yet to be clearly defined. We aimed to describe the temporal trends in respiratory outcomes over 12 months in patients hospitalised for severe COVID-19 and to investigate the associated risk factors.METHODS: In this prospective, longitudinal, cohort study, patients admitted to hospital for severe COVID-19 who did not require mechanical ventilation were prospectively followed up at 3 months, 6 m...
Source: Respiratory Care - May 8, 2021 Category: Respiratory Medicine Authors: Xiaojun Wu Xiaofan Liu Yilu Zhou Hongying Yu Ruiyun Li Qingyuan Zhan Fang Ni Si Fang Yang Lu Xuhong Ding Hailing Liu Rob M Ewing Mark G Jones Yi Hu Hanxiang Nie Yihua Wang Source Type: research

Association of obesity-related inflammatory pathways with lung function and exercise capacity
We examined 695 patients who underwent cardiopulmonary exercise testing (CPET) with invasive hemodynamic monitoring at Massachusetts General Hospital between December 2006-June 2017. We investigated the association of adiponectin, leptin, resistin, IL-6, CRP, and insulin resistance (HOMA-IR) with pulmonary function and exercise parameters using multivariable linear regression.RESULTS: Obesity-related inflammatory pathways were associated with worse lung function. Specifically, higher CRP, IL-6, and HOMA-IR were associated with lower percent predicted FEV1 and FVC with a preserved FEV1/FVC ratio suggesting a restrictive phy...
Source: Respiratory Care - May 8, 2021 Category: Respiratory Medicine Authors: Jenna N McNeill Emily S Lau Emily K Zern Matthew Nayor Rajeev Malhotra Elizabeth E Liu Rohan R Bhat Liana C Brooks Robyn Farrell John A Sbarbaro Mark W Schoenike Benjamin D Medoff Gregory D Lewis Jennifer E Ho Source Type: research

Antiviral treatment selection for SARS-CoV-2 pneumonia
Expert Rev Respir Med. 2021 May 7. doi: 10.1080/17476348.2021.1927719. Online ahead of print.ABSTRACTINTRODUCTION: Therapy of coronavirus disease 2019 (COVID-19) involves evolving algorithms that include drugs aimed at reducing disease progression by counteracting two different, but intertwined processes: (i) the damage caused by the virus (with antivirals); (ii) the damage caused by a dysregulated host response (with immunomodulatory agents).AREAS COVERED: Herein, we discuss the available evidence on efficacy and safety of antiviral agents employed over the past months for the treatment of COVID-19, and the reasons to be ...
Source: Respiratory Care - May 8, 2021 Category: Respiratory Medicine Authors: Matteo Bassetti Silvia Corcione Silvia Dettori Andrea Lombardi Tommaso Lupia Antonio Vena Francesco Giuseppe De Rosa Andrea Gori Daniele Roberto Giacobbe Source Type: research