Indoor exposure to particulate matter and volatile organic compounds in dwellings and workplaces and respiratory health in French farmers.
Abstract Introduction: Few investigations have related objective assessments of indoor air pollutants to respiratory health in farmers, in spite of the many rural environmental hazards to which they are exposed. Chemical air pollution has been particularly neglected. Objective: We investigated the relationships of indoor exposure to particulate matter (PM) and volatile organic compounds (VOCs) to respiratory health in farmers. Methods: Nineteen VOCs (5 families) and PM (from ultrafine to total suspended particles (TSP)) were objectively assessed in dwellings and workplaces in 109 French farmers du...
Source: Respiratory Care - October 11, 2019 Category: Respiratory Medicine Authors: Maesano CN, Caillaud D, Youssouf H, Banerjee S, Prud'Homme J, Audi C, Horo K, Toloba Y, Ramousse O, Annesi-Maesano I Tags: Multidiscip Respir Med Source Type: research

Erratum: Ventilatory equivalent for oxygen as an extubation outcome predictor: A pilot study.
Abstract [This corrects the article on p. 65 in vol. 55, PMID: 31489359.]. PMID: 31595225 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - October 11, 2019 Category: Respiratory Medicine Authors: Ellens T, Kaur R, Roehl K, Dubosky M, Vines DL Tags: Can J Respir Ther Source Type: research

Palliative care as an emerging role for respiratory health professionals: Findings from a cross-sectional, exploratory Canadian survey.
Conclusions: As RHP roles continue to evolve, consideration should be given to the ways in which RHPs can contribute to improving the quality of care for patients with advanced respiratory disease. Building collaborations with RHPs, palliative care, and other existing health programs can ensure high quality of care. Creating and taking advantage of learning opportunities to build skills and comfort in using a palliative approach will benefit respiratory patients. PMID: 31595226 [PubMed] (Source: Respiratory Care)
Source: Respiratory Care - October 11, 2019 Category: Respiratory Medicine Authors: Goodridge D, Peters J Tags: Can J Respir Ther Source Type: research

Meta-analysis of vitamin D and lung function in patients with asthma.
Abstract BACKGROUND: There is growing literature suggesting a link between vitamin D and asthma lung function, but the results from systematic reviews are conflicting. We conducted this meta-analysis to investigate the relation between serum vitamin D and lung function in asthma patients. METHODS: Major databases, including OVID, MEDLINE, Web of Science and PUBMED, were searched until 10th October 2018. All published observational studies related to vitamin D and asthma were extracted. All meta-analyses were performed using Review Manager 5.3.5. RESULTS: This quantitative synthesis found that asthma pati...
Source: Respiratory Care - October 8, 2019 Category: Respiratory Medicine Authors: Liu J, Dong YQ, Yin J, Yao J, Shen J, Sheng GJ, Li K, Lv HF, Fang X, Wu WF Tags: Respir Res Source Type: research

The Use of Ultrasound as a Tool to Evaluate Pulmonary Disease in Cystic Fibrosis.
CONCLUSIONS: Lung ultrasound seems to be effective and corroborates with high-resolution computed tomography when evaluated by the modified Bhalla score. At the same time, lung ultrasound had significant correlation with pulmonary function and nutritional status. PMID: 31594833 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - October 8, 2019 Category: Respiratory Medicine Authors: Peixoto AO, Marson FA, Dertkigil SS, Dertkigil RP, Souza TH, Fraga AM, Ribeiro AF, Toro AA, Ribeiro JD Tags: Respir Care Source Type: research

Real-world evidence effect of budesonide+formoterol Spiromax on patients with asthma and chronic obstructive pulmonary disease in Sweden.
This study evaluated costs and outcomes associated with budesonide+formoterol (BF) Spiromax® initiation among real-world Swedish patients with asthma and/or COPD. Methods:In this retrospective observational analysis of Swedish patients with asthma and/or COPD, data were collected from the National Patient Register, National Dispensed Drug Register, and Cause of Death Register 1 year before and after initiating BF Spiromax (index date). Outcomes included exacerbation occurrence, treatment patterns, inpatient care, and healthcare costs. Results: The study included 576 patients (asthma: 51.6%; COPD: 32.8%; and asthma and ...
Source: Respiratory Care - October 5, 2019 Category: Respiratory Medicine Authors: Janson C, Benhaddi H, Törnblom M, Uhde M, Johansson G Tags: Eur Clin Respir J Source Type: research

Reduced Step Count and Clinical Frailty in Hospitalized Adults With Community-Acquired Pneumonia.
CONCLUSIONS: Subjects hospitalized with CAP did very little walking, most of which was accumulated in short bouts at a low intensity. Compared with subjects with mild frailty, those with moderate to severe frailty took 59% fewer steps per day. Those with a higher daily step count had a shorter LOS. PMID: 31575707 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - October 1, 2019 Category: Respiratory Medicine Authors: Rice H, Hill K, Fowler R, Watson C, Waterer G, Harrold M Tags: Respir Care Source Type: research

Noninvasive Ventilation for Critically Ill Subjects With Acute Respiratory Failure in the Emergency Department.
CONCLUSIONS: Although any exposure to NIV prior to invasive mechanical ventilation did not appear to affect morbidity and mortality, extended NIV use prior to invasive mechanical ventilation was associated with worse patient outcomes, suggesting a need for additional study to better understand the ramifications of duration of NIV use prior to failure on outcomes. Given this early timeframe for intervention, future studies should be collaborations between the emergency department and ICU. PMID: 31575708 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - October 1, 2019 Category: Respiratory Medicine Authors: Goel NN, Owyang C, Ranginwala S, Loo GT, Richardson LD, Mathews KS Tags: Respir Care Source Type: research

A Comparison of Practice Patterns Among Certified and Noncertified Asthma Educators.
CONCLUSION: For a majority of the education tasks, certified versus noncertified responses did not differ in their reported frequency of performing education tasks. Future researcher should examine the potential differences in patient outcomes based on provider certification status. PMID: 31575709 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - October 1, 2019 Category: Respiratory Medicine Authors: Rice JB, Mathieson KM Tags: Respir Care Source Type: research

Aerosol Delivery During Continuous High Frequency Oscillation for Simulated Adults During Quiet and Distressed Spontaneous Breathing.
Abstract BACKGROUND: Continuous high-frequency oscillation (CHFO) is a therapeutic mode for the mobilization of secretions. The Metaneb CHFO device (Hill-Rom) also incorporates aerosol administration using an integrated jet nebulizer. However, the effectiveness of aerosol delivery and influential factors remain largely unreported. METHODS: A collecting filter was placed between an adult manikin with a representative upper airway and a breath simulator, set to simulate quiet and distressed patterns of spontaneous adult breathing. The Metaneb CHFO device was attached to the manikin via a mask. Two jet nebulizer...
Source: Respiratory Care - October 1, 2019 Category: Respiratory Medicine Authors: Li J, Elshafei AA, Gong L, Fink JB Tags: Respir Care Source Type: research

Predictors of Negative Pressure Ventilation Response in Pediatric Acute Respiratory Failure.
CONCLUSIONS: Negative-pressure ventilation successfully supported 69% of pediatric subjects with all-cause acute respiratory failure. Oxygen requirement was lower in subjects who were responsive to negative-pressure ventilation within 1 h of initiation. Standardized negative-pressure ventilation protocols should include weaning of supplemental oxygen to determine responsiveness. PMID: 31575711 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - October 1, 2019 Category: Respiratory Medicine Authors: Nunez CA, Hassinger AB Tags: Respir Care Source Type: research

Prevalence of and Risk Factors for Mechanical Ventilation Reinstitution in Patients Weaned From Prolonged Mechanical Ventilation.
CONCLUSION: Reinstitution of mechanical ventilation within 28 d is a common event in patients considered to be weaned: 1 in 5 of such patients requires reconnection to mechanical ventilation, with sepsis being the most prevalent cause. Neurological comorbidity and delayed weaning are risk factors associated with reestablishment of mechanical ventilation. The presence of more than one risk factor increases the association with reinstitution of mechanical ventilation within 28 d of weaning. PMID: 31575712 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - October 1, 2019 Category: Respiratory Medicine Authors: Villalba D, Gil Rossetti G, Scrigna M, Collins J, Rocco A, Matesa A, Areas L, Golfarini N, Pini P, Hannun M, Boni S, Grimaldi S, Pedace P, Díaz-Ballve L, Andreu M, Buñirigo P, Noval D, Planells F Tags: Respir Care Source Type: research

Lung Expansion Therapy: Please, (Visually) Show Me the Value!
PMID: 31575789 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - October 1, 2019 Category: Respiratory Medicine Authors: Piraino T Tags: Respir Care Source Type: research

Predicting Response to PEEP in Mechanically Ventilated Pediatric Patients: What Are the Odds?
PMID: 31575790 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - October 1, 2019 Category: Respiratory Medicine Authors: Straube TL, Rehder KJ, Turner DA Tags: Respir Care Source Type: research

Can Thyroid Hormone Strengthen the Diaphragm in Nonthyroidal Illness?
PMID: 31575791 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - October 1, 2019 Category: Respiratory Medicine Authors: Rappaport CA, Schmidt GA Tags: Respir Care Source Type: research

Editor's Commentary.
Authors: PMID: 31575792 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - October 1, 2019 Category: Respiratory Medicine Tags: Respir Care Source Type: research

Genetic diversity of respiratory enteroviruses and rhinoviruses in febrile adults, Singapore, 2007-2013.
This study highlights the previously unrecognized diversity and burden in the adult population in Singapore. PMID: 31568667 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - September 30, 2019 Category: Respiratory Medicine Authors: Linster M, Donato C, Mah MG, Grau ML, Low JG, Ooi EE, Su YCF, Smith GJD, Vijaykrishna D Tags: Influenza Other Respir Viruses Source Type: research

Update on oral appliance therapy.
Abstract Oral appliances are increasingly recommended for selected patients with obstructive sleep apnoea (OSA) and those who do not tolerate nor prefer continuous positive airway pressure. The most commonly used oral appliance advances the lower jaw during sleep, the so-called mandibular advancement device (MAD). Patients seek treatment because of disturbing snoring, daytime symptoms, apnoeas that disturb sleep and the longer term consequences with regard to cardiovascular risks. MADs reduce the apnoea-hypopnoea index, although to various degrees among patients. Effects on daytime sleepiness have been observed ma...
Source: Respiratory Care - September 28, 2019 Category: Respiratory Medicine Authors: Marklund M, Braem MJA, Verbraecken J Tags: Eur Respir Rev Source Type: research

New organisation for follow-up and assessment of treatment efficacy in sleep apnoea.
Abstract Obstructive sleep apnoea (OSA) is a highly prevalent disease, and there is an increased demand for OSA diagnosis and treatment. However, resources are limited compared with the growing needs for OSA diagnosis and management, and alternative strategies need to be developed to optimise the OSA clinical pathway. In this review, we propose a management strategy for OSA, and in general for sleep-disordered breathing, to be implemented from diagnosis to follow-up. For this purpose, the best current options seem to be: 1) networking at different levels of care, from primary physicians to specialised sleep labora...
Source: Respiratory Care - September 14, 2019 Category: Respiratory Medicine Authors: Suarez-Giron M, Bonsignore MR, Montserrat JM Tags: Eur Respir Rev Source Type: research

The therapy of idiopathic pulmonary fibrosis: what is next?
r M Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung disease, characterised by progressive scarring of the lung and associated with a high burden of disease and early death. The pathophysiological understanding, clinical diagnostics and therapy of IPF have significantly evolved in recent years. While the recent introduction of the two antifibrotic drugs pirfenidone and nintedanib led to a significant reduction in lung function decline, there is still no cure for IPF; thus, new therapeutic approaches are needed. Currently, several clinical phase I-III trials are fo...
Source: Respiratory Care - September 7, 2019 Category: Respiratory Medicine Authors: Somogyi V, Chaudhuri N, Torrisi SE, Kahn N, Müller V, Kreuter M Tags: Eur Respir Rev Source Type: research

Obstructive sleep apnoea in acute coronary syndrome.
Abstract Obstructive sleep apnoea (OSA) syndrome affects about 13% of the male and 7-9% of the female population. Hypoxia, oxidative stress and systemic inflammation link OSA and cardiovascular and metabolic consequences, including coronary artery disease. Current research has identified several clinical phenotypes, and the combination of breathing disturbances during sleep, systemic effects and end-organ damage might help to develop personalised therapeutic approaches. It is unclear whether OSA is a risk factor for acute coronary syndrome (ACS) and might affect its outcome. On the one hand, OSA in patients with A...
Source: Respiratory Care - August 3, 2019 Category: Respiratory Medicine Authors: Randerath W, Bonsignore MR, Herkenrath S Tags: Eur Respir Rev Source Type: research

VV-ECMO for surgical cure of a critical central airway obstruction.
Abstract Extracorporeal membrane oxygenation (ECMO) is a form of prolonged cardiopulmonary bypass that has extensively been used in critically ill patients in an intensive care setting. Both veno-venous (VV-) and veno-arterial (VA-) ECMO have been described as a perioperative rescue or replacement of endotracheal intubation in the setting of extrinsic airway compression due to a mediastinal mass. In this paper, we will outline the utility of ECMO in the context of extrinsic airway compression and will use an illustrative case to examine how ECMO can be useful during severe airway obstruction. Our patient successfu...
Source: Respiratory Care - August 3, 2019 Category: Respiratory Medicine Authors: Raza HA, Nokes BT, Jaroszewski D, Garrett A, Sista R, Ross J, Farmer JC, Lyng PJ Tags: Respir Med Case Rep Source Type: research

Ventilator-Associated Events: What They Are and What They Are Not.
Abstract In 2013, the United States Centers for Disease Control and Prevention redefined surveillance for quality of care in ventilated patients by shifting from ventilator-associated pneumonia (VAP) definitions to ventilator-associated event (VAE) definitions. VAE definitions were designed to overcome many of the limitations of VAP definitions, including their complexity, subjectivity, limited correlation with outcomes, and incomplete capture of many important and morbid complications of mechanical ventilation. VAE definitions broadened the focus of surveillance from pneumonia alone to the syndrome of nosocomial ...
Source: Respiratory Care - July 29, 2019 Category: Respiratory Medicine Authors: Klompas M Tags: Respir Care Source Type: research

Aerosolized Antibiotics for Treatment of Pneumonia in Mechanically Ventilated Subjects.
Abstract Mechanical ventilation is a well-established and commonly employed modality of treatment for critically ill patients in the ICU. Pneumonia is a frequent complication in mechanically ventilated patients. Patients who develop ventilator-associated pneumonia (VAP) incur higher medical costs, have prolonged ICU and hospital stays, and have increased mortality risk. There is growing interest in finding new treatment modalities for this condition because the success rate for treating VAP with systemic antibiotics continues to be
Source: Respiratory Care - July 29, 2019 Category: Respiratory Medicine Authors: Wong FJ, Dudney T, Dhand R Tags: Respir Care Source Type: research

The Role of Specialty Tubes in Preventing Ventilator-Associated Events.
This article reviews the evidence related to specialty tubes and discusses their role in improving objective outcomes associated with ventilator-associated events. PMID: 31346072 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - July 29, 2019 Category: Respiratory Medicine Authors: Piraino T Tags: Respir Care Source Type: research

Airway Management and Ventilator-Associated Events.
Abstract Airway management techniques are aimed at reducing complications associated with artificial airways and mechanical ventilation, such as retained secretions. The impact of airway management techniques on ventilator-associated events (VAEs) varies considerably by modality. Closed-suction techniques are generally recommended but have limited, if any, impact on VAEs. Normal saline instillation during suctioning is not recommended. Devices designed specifically to remove biofilm from the inside of endotracheal tubes appear to be safe, but their role in VAE prevention is uncertain. Subglottic secretion clearanc...
Source: Respiratory Care - July 29, 2019 Category: Respiratory Medicine Authors: Dexter AM, Scott JB Tags: Respir Care Source Type: research

Ventilator Bundles in Transition: From Prevention of Ventilator-Associated Pneumonia to Prevention of Ventilator-Associated Events.
Abstract Implementation of ventilator bundles is associated with reductions in ventilator-associated pneumonia (VAP). However, the new surveillance model of ventilator-associated events (VAEs) has shifted the focus from VAP to objective, generalized signs of pulmonary decompensation not specific to VAP. This raises the question of whether the ventilator bundle also is effective in reducing VAE. This narrative review examined 6 studies published since 2013 that assessed the impact of ventilator bundles on the incidence of VAE, and a seventh study that examined its impact on mortality. All 7 studies were low-level e...
Source: Respiratory Care - July 29, 2019 Category: Respiratory Medicine Authors: Kallet RH Tags: Respir Care Source Type: research

2018 Year in Review: Sleep.
Abstract Sleep-disordered breathing affects a significant portion of the population worldwide. It is associated with many comorbid conditions, including heart failure and depression. Advances in the field regarding the diagnosis and treatment of sleep-disordered breathing are occurring on an increasing basis. This review will discuss the latest findings in the field with an emphasis on people who have obstructive sleep apnea. PMID: 31346075 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - July 29, 2019 Category: Respiratory Medicine Authors: Carlin BW Tags: Respir Care Source Type: research

Moving the Practice of Respiratory Therapy Forward.
PMID: 31346076 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - July 29, 2019 Category: Respiratory Medicine Authors: Kollef MH, Watts P Tags: Respir Care Source Type: research

Driving Pressure: The Road Ahead.
PMID: 31346077 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - July 29, 2019 Category: Respiratory Medicine Authors: Sahetya SK, Fan E Tags: Respir Care Source Type: research

Spontaneous Inspiratory Effort During Lung-Protective Ventilation.
PMID: 31346078 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - July 29, 2019 Category: Respiratory Medicine Authors: Deem S Tags: Respir Care Source Type: research

Editor's Commentary.
Authors: PMID: 31346079 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - July 29, 2019 Category: Respiratory Medicine Tags: Respir Care Source Type: research

Unconscious bias in the selection and interpretation of data on sex and burnout - Authors' reply.
am EL, Dodek PM, Moss M PMID: 31342898 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - July 27, 2019 Category: Respiratory Medicine Authors: Authors' reply. Tags: Lancet Respir Med Source Type: research

Elucidating the causes of asthma: how can we do better?
PMID: 31342899 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - July 27, 2019 Category: Respiratory Medicine Authors: Shaheen S Tags: Lancet Respir Med Source Type: research

A transudative chylothorax associated with superior vena cava syndrome.
Abstract The chylothorax is a lymphocyte predominant protein-discordant exudative pleural effusions with low lactate dehydrogenase and elevated triglyceride levels. Transudative chylothoraces associated with Superior Cava syndrome (SVC) are an extremely rare clinical entity. In this manuscript, we describe a case of transudative chylothorax due to SVC obstruction secondary to thrombosis of a peripheral inserted central venous catheter, which ultimately resolved after endovascular intervention. In our review of the literature, only five cases of transudative chylothorax associated with SVC syndrome were identified ...
Source: Respiratory Care - July 26, 2019 Category: Respiratory Medicine Authors: Austin A, Al-Faris F, Modi A, Chopra A Tags: Respir Med Case Rep Source Type: research

Estimation of influenza- and respiratory syncytial virus-attributable medically attended acute respiratory infections in Germany, 2010/11-2017/18.
CONCLUSIONS: We succeeded in rearranging our previously published model on MAARI to incorporate RSV as well as the two influenza B lineages (Victoria, Yamagata) in the time period 2010 to 2018. PMID: 31339223 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2019 Category: Respiratory Medicine Authors: An der Heiden M, Buchholz U, Buda S Tags: Influenza Other Respir Viruses Source Type: research

Users' Experiences With Home Mechanical Ventilation: A Review of Qualitative Studies.
CONCLUSIONS: According to the users, treatment by home mechanical ventilation resulted in increased well-being and facilitated a community- and home-based lifestyle compared with institutional-based treatment. However, the users also expressed difficulties in coming to terms with the necessary extensive surveillance, which gave rise to a sense of undermined autonomy and self-determinism as well as continued worries and uncertainty. The users called this situation dependent independency. As a result of the review we call for an increased focus on a patient-centered treatment and care. PMID: 31337740 [PubMed - as suppli...
Source: Respiratory Care - July 23, 2019 Category: Respiratory Medicine Authors: Ørtenblad L, Carstensen K, Væggemose U, Løvschall C, Sprehn M, Küchen S, Nørregaard O, Jensen LG Tags: Respir Care Source Type: research

Noninvasive Ventilation Device-Related Pressure Injury in a Children's Hospital.
CONCLUSIONS: After multivariate analysis, only high mask leak was significantly associated with developing a pressure injury. Identifying risk factors that correlate with NIV device-related hospital acquired pressure injuries in children can direct procedures to prevent pressure injury in hospitalized children at high risk. PMID: 31337741 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - July 23, 2019 Category: Respiratory Medicine Authors: Lauderbaugh DL, Bhattacharjee R, Proudfoot J, Ortega EV, Pratt LA, Popien TL, Lesser DJ Tags: Respir Care Source Type: research

Comparison of End-Tidal, Arterial, Venous, and Transcutaneous PCO2.
Abstract BACKGROUND: We investigated the measurement of end-tidal partial pressure of carbon dioxide (P ETCO2 ) with a capnometer in patients with respiratory failure, and we determined whether this technique could provide an alternative to measurement of P aCO2 using arterial blood gas analysis in the clinical setting. METHODS: We measured P ETCO2 in subjects with hypoxemic and hypercarbic respiratory failure using a capnometer. We simultaneously measured P aCO2 , venous partial pressure of carbon dioxide (P V̇CO2 ), and transcutaneously measured partial pressure P CO2 (P tcCO2 ). We analyzed agreements amo...
Source: Respiratory Care - July 23, 2019 Category: Respiratory Medicine Authors: Fujimoto S, Suzuki M, Sakamoto K, Ibusuki R, Tamura K, Shiozawa A, Ishii S, Iikura M, Izumi S, Sugiyama H Tags: Respir Care Source Type: research

Prospective Effects of Manual Diaphragmatic Release and Thoracic Lymphatic Pumping in Childhood Asthma.
Abstract BACKGROUND: Manual noninvasive respiratory techniques have traditionally been used to treat respiratory pathologies. The aim of this study was to analyze the effects of the diaphragmatic release technique and the thoracic lymphatic pump technique versus conventional respiratory retraining in children with asthma. METHODS: Using a quasi-experimental design, 60 children with asthma were allocated to undergo the diaphragmatic release technique (n = 20), thoracic lymphatic pump technique (n = 20), or conventional respiratory retraining (n = 20) in this study. Serum immunoglobulin E levels, diaphragmatic ...
Source: Respiratory Care - July 23, 2019 Category: Respiratory Medicine Authors: Elnaggar RK, Shendy MA, Mahmoud MZ Tags: Respir Care Source Type: research

Performance of Noninvasive Ventilation Masks in a Lung Model of COPD Exacerbation.
We presented the mean ± SD of the 8 simulated conditions for each mask. The mean ± SD leakage was higher for the total face mask (51 ± 6 L/min) than for the small oronasal mask (37 ± 5 L/min) and for the large oronasal mask (21 ± 3 L/min), P
Source: Respiratory Care - July 23, 2019 Category: Respiratory Medicine Authors: Rocha de Macedo B, Rego FMP, Diniz Silva F, Pinaffi JV, Ferreira JC Tags: Respir Care Source Type: research

New frontiers in applied veterinary point-of-capture diagnostics: Toward early detection and control of zoonotic influenza.
Abstract Among the chief limitations in achieving early detection and control of animal-origin influenza of pandemic potential in high-risk livestock populations is the existing lag time between sample collection and diagnostic result. Advances in molecular diagnostics are permitting deployment of affordable, rapid, highly sensitive, and specific point-of-capture assays, providing opportunities for targeted surveillance driving containment strategies with potentially compelling returns on investment. Interrupting disease transmission at source holds promise of disrupting cycles of animal-origin influenza incursion...
Source: Respiratory Care - July 23, 2019 Category: Respiratory Medicine Authors: Schar D, Padungtod P, Tung N, O'Leary M, Kalpravidh W, Claes F Tags: Influenza Other Respir Viruses Source Type: research

The canonical TGF- β/Smad signalling pathway is involved in PD-L1-induced primary resistance to EGFR-TKIs in EGFR-mutant non-small-cell lung cancer.
CONCLUSION: PD-L1 contributes to primary resistance to EGFR-TKI in EGFR-mutant NSCLC cells, which may be mediated through the induction of EMT via the activation of the TGF-β/Smad canonical signalling pathway. PMID: 31331328 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - July 22, 2019 Category: Respiratory Medicine Authors: Zhang Y, Zeng Y, Liu T, Du W, Zhu J, Liu Z, Huang JA Tags: Respir Res Source Type: research

Impact of blood group on survival following critical illness: a single-centre retrospective observational study.
Conclusion: Although this is primarily a hypothesis generating study, intensive care patients with blood group AB appeared to have a higher 90-day survival compared with other blood groups. There was no correlation between blood group and percentage of patients receiving transfusion. PMID: 31321058 [PubMed] (Source: Respiratory Care)
Source: Respiratory Care - July 20, 2019 Category: Respiratory Medicine Authors: Slade R, Alikhan R, Wise MP, Germain L, Stanworth S, Morgan M Tags: BMJ Open Respir Res Source Type: research

Cryobiopsy versus open lung biopsy in the diagnosis of interstitial lung disease (COLDICE): protocol of a multicentre study.
Abstract Introduction: Transbronchial lung cryobiopsy (TBLC) is a novel, minimally invasive technique for obtaining lung tissue for histopathological assessment in interstitial lung disease (ILD). Despite its increasing popularity, the diagnostic accuracy of TBLC is not yet known. The COLDICE Study (Cryobiopsy versus Open Lung biopsy in the Diagnosis of Interstitial lung disease allianCE) aims to evaluate the agreement between TBLC and surgical lung biopsy sampled concurrently from the same patients, for both histopathological and multidisciplinary discussion (MDD) diagnoses. Methods and analysis: This compar...
Source: Respiratory Care - July 20, 2019 Category: Respiratory Medicine Authors: Troy LK, Grainge C, Corte T, Williamson JP, Vallely MP, Cooper W, Mahar AM, Lai S, Mulyadi E, Torzillo PJ, Salamonsen M, Don G, Myers J, Raghu G, Lau EMT, COLDICE Investigator Team Tags: BMJ Open Respir Res Source Type: research

Approaching Clinical Trials in Childhood ILD (chILD) and Pediatric Pulmonary Fibrosis.
Abstract Childhood interstitial lung disease (chILD) comprises a spectrum of rare diffuse lung disorders. chILD is heterogeneous in origin, with differing disease manifestations occurring in the context of ongoing lung development. The large number of disorders in chILD, in combination with the rarity of each diagnosis, has hampered scientific and clinical progress within the field. Epidemiologic and natural history data are limited. Prognosis varies depending on the etiology, with some forms progressing to lung transplant or death. There are limited treatment options for patients with chILD. Although US Food and ...
Source: Respiratory Care - July 19, 2019 Category: Respiratory Medicine Authors: Deterding RR, DeBoer EM, Cidon MJ, Robinson TE, Warburton D, Deutsch GH, Young LR Tags: Am J Respir Crit Care Med Source Type: research

Reply to Isayama and Shah, and to Bancalari et al.
PMID: 31322416 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - July 19, 2019 Category: Respiratory Medicine Authors: Jensen EA Tags: Am J Respir Crit Care Med Source Type: research

Classifying Amyotrophic Lateral Sclerosis Patients by Changes in Forced Vital Capacity: A Group-Based Trajectory Analysis.
This study sought to categorize progression of forced vital capacity (FVC) after presentation to an outpatient ALS clinic. OBJECTIVES: We derived a group-based trajectory model (GBTM) from a single-center cohort of 837 ALS patients who presented between 2006 and 2015. We applied our model to the Pooled Resource Open-Access ALS Clinical Trials (PROACT) database with 7,461 ALS patients. Baseline characteristics at first visit were used as predictors of trajectory group membership. The primary outcome was trajectory of FVC over time in months. MEASUREMENTS AND MAIN RESULTS: We found three trajectories of FVC over ti...
Source: Respiratory Care - July 19, 2019 Category: Respiratory Medicine Authors: Ackrivo J, Hansen-Flaschen J, Jones BL, Wileyto EP, Schwab RJ, Elman L, Kawut SM Tags: Am J Respir Crit Care Med Source Type: research

Assessment of Inflammation in Pulmonary Artery Hypertension by 68Ga-Mannosylated Human Serum Albumin.
Conclusions: 68Ga-NOTA-MSA PET can help diagnose PAH and monitor the inflammatory status by imaging the degree of macrophage infiltration into the lung. These observations suggest that 68Ga-NOTA-MSA PET has the potential to be used as a novel noninvasive diagnostic and monitoring tool of PAH. PMID: 31322420 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - July 19, 2019 Category: Respiratory Medicine Authors: Park JB, Suh M, Park JY, Park JK, Kim YI, Kim H, Cho YS, Kang H, Kim K, Choi JH, Nam JW, Kim HK, Lee YS, Jeong JM, Kim YJ, Paeng JC, Lee SP Tags: Am J Respir Crit Care Med Source Type: research

Need for an International Consensus on BPD Definition.
PMID: 31322422 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - July 19, 2019 Category: Respiratory Medicine Authors: Isayama T, Shah PS Tags: Am J Respir Crit Care Med Source Type: research