COVID-19 Clinical Phenotypes and Short-term Outcomes: Differences Between the First and the Second Wave of Pandemic in Italy
CONCLUSION: The present findings showed a clear phenotypic difference in patients hospitalized at different stages of the COVID-19 pandemic in Italy. These results can help to stratify clinical risk and to better tailor medical treatments and respiratory supports for patients with ARDS and COVID-19 pneumonia.PMID:34311634 | DOI:10.1080/17476348.2021.1960824 (Source: Respiratory Care)
Source: Respiratory Care - July 27, 2021 Category: Respiratory Medicine Authors: Andrea Portacci Giovanna Elisiana Carpagnano Maria Grazia Tummolo Carla Santomasi Lavinia Palma Domenico Fasano Emanuela Resta Madia Lozupone Vincenzo Solfrizzi Francesco Panza Onofrio Resta Source Type: research

Lung transplant to manage end-stage lung disease due to idiopathic pulmonary hemosiderosis: A review of the literature
The objective of the present project was to scrutinize the literature and summarize the demographic, clinical, radiological, and histopathological features, as well as the overall outcomes, in this patient population following lung transplant. The Medline database was searched using the PubMed platform. Articles published in English between 1960 and 2020 were included in the search. Different search terms were used to identify all patients who underwent lung transplantation to manage ESLD due to IPH. Only four cases of lung transplantation have been reported in the literature in patients with IPH. All but one of these unde...
Source: Respiratory Care - July 27, 2021 Category: Respiratory Medicine Authors: Biplab K Saha Woon H Chong Source Type: research

Early respiratory diagnosis: benefits of enhanced lung function assessment
BMJ Open Respir Res. 2021 Jul;8(1):e001012. doi: 10.1136/bmjresp-2021-001012.ABSTRACTINTRODUCTION: The National Health Service for England Long Term Plan identifies respiratory disease as one of its priority workstreams. To assist with earlier and more accurate diagnosis of lung disease they recommend improvement in delivery of quality-assured spirometry. However, there is a likelihood that patients will present with abnormal gas exchange when spirometry results are normal and therefore there will be a proportion of patients whose time to diagnosis is still protracted. We wished to determine the incidence rate of this occu...
Source: Respiratory Care - July 27, 2021 Category: Respiratory Medicine Authors: Karl P Sylvester Luke Youngs M A Rutter Ross Beech Ravi Mahadeva Source Type: research

Experiences of nurses caring for respiratory patients during the first wave of the COVID-19 pandemic: an online survey study
CONCLUSIONS: Support for staff is essential both throughout the pandemic and afterwards, and it is important that preparation of individuals regarding building resilience is recognised. It is also clear that psychological support and services for nurses and the wider healthcare team need to be available and quickly convened in the event of similar major incidents, either global or local.PMID:34312256 | DOI:10.1136/bmjresp-2021-000987 (Source: Respiratory Care)
Source: Respiratory Care - July 27, 2021 Category: Respiratory Medicine Authors: Nicola J Roberts Carol A Kelly Kate A Lippiett Emma Ray Lindsay Welch Source Type: research

Advancing precision medicine for acute respiratory distress syndrome
Lancet Respir Med. 2021 Jul 23:S2213-2600(21)00157-0. doi: 10.1016/S2213-2600(21)00157-0. Online ahead of print.ABSTRACTAcute respiratory distress syndrome (ARDS) is a heterogeneous clinical syndrome. Understanding of the complex pathways involved in lung injury pathogenesis, resolution, and repair has grown considerably in recent decades. Nevertheless, to date, only therapies targeting ventilation-induced lung injury have consistently proven beneficial, and despite these gains, ARDS morbidity and mortality remain high. Many candidate therapies with promise in preclinical studies have been ineffective in human trials, prob...
Source: Respiratory Care - July 26, 2021 Category: Respiratory Medicine Authors: Jeremy R Beitler B Taylor Thompson Rebecca M Baron Julie A Bastarache Loren C Denlinger Laura Esserman Michelle N Gong Lisa M LaVange Roger J Lewis John C Marshall Thomas R Martin Daniel F McAuley Nuala J Meyer Marc Moss Lora A Reineck Eileen Rubin Eric P Source Type: research

Qualitative coronary artery calcification scores and risk of all cause, COPD and pneumonia hospital admission in a large CT lung cancer screening cohort
CONCLUSION: Qualitative CAC on CTLS exams identifies individuals at elevated risk for all cause, pneumonia and COPD-related hospital admissions.PMID:34311389 | DOI:10.1016/j.rmed.2021.106540 (Source: Respiratory Care)
Source: Respiratory Care - July 26, 2021 Category: Respiratory Medicine Authors: Lee Gazourian Shawn M Regis Elizabeth J Pagura Lori Lyn Price Melissa Gawlik Carla Lamb Kimberly M Rieger-Christ William B Thedinger Ava M Sanayei William P Long Cristina F Stefanescu Giulia S Rizzo Avignat S Patel Carolyn E Come Carey C Thomson Victor Pi Source Type: research

Advancing precision medicine for acute respiratory distress syndrome
Lancet Respir Med. 2021 Jul 23:S2213-2600(21)00157-0. doi: 10.1016/S2213-2600(21)00157-0. Online ahead of print.ABSTRACTAcute respiratory distress syndrome (ARDS) is a heterogeneous clinical syndrome. Understanding of the complex pathways involved in lung injury pathogenesis, resolution, and repair has grown considerably in recent decades. Nevertheless, to date, only therapies targeting ventilation-induced lung injury have consistently proven beneficial, and despite these gains, ARDS morbidity and mortality remain high. Many candidate therapies with promise in preclinical studies have been ineffective in human trials, prob...
Source: Respiratory Care - July 26, 2021 Category: Respiratory Medicine Authors: Jeremy R Beitler B Taylor Thompson Rebecca M Baron Julie A Bastarache Loren C Denlinger Laura Esserman Michelle N Gong Lisa M LaVange Roger J Lewis John C Marshall Thomas R Martin Daniel F McAuley Nuala J Meyer Marc Moss Lora A Reineck Eileen Rubin Eric P Source Type: research

Qualitative coronary artery calcification scores and risk of all cause, COPD and pneumonia hospital admission in a large CT lung cancer screening cohort
CONCLUSION: Qualitative CAC on CTLS exams identifies individuals at elevated risk for all cause, pneumonia and COPD-related hospital admissions.PMID:34311389 | DOI:10.1016/j.rmed.2021.106540 (Source: Respiratory Care)
Source: Respiratory Care - July 26, 2021 Category: Respiratory Medicine Authors: Lee Gazourian Shawn M Regis Elizabeth J Pagura Lori Lyn Price Melissa Gawlik Carla Lamb Kimberly M Rieger-Christ William B Thedinger Ava M Sanayei William P Long Cristina F Stefanescu Giulia S Rizzo Avignat S Patel Carolyn E Come Carey C Thomson Victor Pi Source Type: research

Single-inhaler triple vs single-inhaler dual therapy in patients with chronic obstructive pulmonary disease: a meta-analysis of randomized control trials
CONCLUSIONS: This meta-analysis suggests that single-inhaler triple therapy is effective in reducing the risk of death of any cause and of moderate or severe exacerbation in COPD patients. However, the risk of pneumonia is higher with ICS/LAMA/LABA FDC than with LABA/LAMA FDC. Trial registration PROSPERO #CRD42020186726.PMID:34301267 | DOI:10.1186/s12931-021-01794-w (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Huanyu Long Hongxuan Xu Jean-Paul Janssens Yanfei Guo Source Type: research

The challenge of asthma control grading in clinical practice
Respir Investig. 2021 Jul 20:S2212-5345(21)00109-X. doi: 10.1016/j.resinv.2021.06.001. Online ahead of print.ABSTRACTAsthma is a chronic disease for which control is considered the management goal. However, the different methods to measure asthma control, including the Global Initiative for Asthma (GINA) criteria and Asthma Control Test (ACT), can produce conflicting results. This nationwide pediatric study compared both methods in 465 enrolled children (322 males, mean age 11.2 years). Lung function and symptom perception were also evaluated. The results showed fair concordance (k = 0.253) between GINA grading and childho...
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Maria Angela Tosca Irene Schiavetti Giorgio Ciprandi “ControL’Asma” Study Group Source Type: research

Low utilisation of bronchoscopy to assess COVID-19 respiratory infection: a multicenter experience
CONCLUSIONS: BAL was used infrequently to assess COVID-19 in busy institutions. NP swabs have a high concordance with BAL for COVID-19 testing, but negative NP swabs should be confirmed with BAL when clinical suspicion is high.PMID:34301713 | DOI:10.1136/bmjresp-2021-000962 (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Kamran Mahmood Matt Abbott Keriann Van Nostrand Rabih Bechara Anne V Gonzalez Amanda Brucker Cynthia L Green Christopher R Polage Source Type: research

Adverse Events of Prone Positioning in Mechanically Ventilated Adults with Acute Respiratory Distress Syndrome
CONCLUSIONS: We identified>40 adverse events reported in prone positioning ARDS studies, involving additional AEs not yet reported by previous systematic reviews. The pooled adverse event proportions collected in this review could guide research and clinical practice decisions, and the strategies to mitigate adverse events could promote future consensus-based recommendations.PMID:34301802 | DOI:10.4187/respcare.09194 (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Felipe Gonz ález-Seguel Juan Jos é Pinto-Concha Nadine Aranis Jaime Leppe Source Type: research

Intraoperative Ventilation in the High-Risk Surgical Patient
Respir Care. 2021 Aug;66(8):1337-1340. doi: 10.4187/respcare.09170.ABSTRACTPostoperative pulmonary complications contribute to perioperative morbidity and mortality in addition to being associated with increased health care costs. In this review article, we outline risk factors for the development postoperative pulmonary complications, describe their impact on perioperative outcomes, and focus on the role of intraoperative ventilation strategies in decreasing postoperative pulmonary complications.PMID:34301857 | DOI:10.4187/respcare.09170 (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Angela Meier Diana Hylton Ulrich H Schmidt Source Type: research

Creating a Process of Research in Respiratory Care
Respir Care. 2021 Aug;66(8):1363-1364. doi: 10.4187/respcare.09367.NO ABSTRACTPMID:34301858 | DOI:10.4187/respcare.09367 (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Richard D Branson Richard H Kallet Source Type: research

Under Pressure: Risks for Injury During Pediatric Noninvasive Ventilation
Respir Care. 2021 Aug;66(8):1365. doi: 10.4187/respcare.09392.NO ABSTRACTPMID:34301859 | DOI:10.4187/respcare.09392 (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Shinya Miura Atsushi Kawaguchi Atsushi Kawaguchi Source Type: research

Is Delivery of Aerosolized Medication via HFNC for Critical Asthma Effective Concurrent Therapy?
Respir Care. 2021 Aug;66(8):1366-1367. doi: 10.4187/respcare.09410.NO ABSTRACTPMID:34301860 | DOI:10.4187/respcare.09410 (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Natalie Napolitano Source Type: research

F < sub > IO < sub > 2 < /sub > < /sub > , P < sub > aO < sub > 2 < /sub > < /sub > , or Else - What Matters in Noninvasive Ventilation in Stable COPD?
Respir Care. 2021 Aug;66(8):1368-1370. doi: 10.4187/respcare.08560.NO ABSTRACTPMID:34301861 | DOI:10.4187/respcare.08560 (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Irena Sarc Kristina Ziherl Antonio M Esquinas Source Type: research

Reply to: F < sub > IO < sub > 2 < /sub > < /sub > , P < sub > aO < sub > 2 < /sub > < /sub > , or Else - What Matters in Noninvasive Ventilation in Stable COPD?
Respir Care. 2021 Aug;66(8):1369-1370. doi: 10.4187/respcare.09172.NO ABSTRACTPMID:34301862 | DOI:10.4187/respcare.09172 (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Michael Cardinale Pierre-Julien Cungi Pierre Esnault Eric Meaudre Philippe Goutorbe Source Type: research

Editor's Commentary
Respir Care. 2021 Aug;66(8):i.NO ABSTRACTPMID:34301863 (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Source Type: research

Risk of complications rise with coronary artery disease and diabetes mellitus after endobronchial valve placement in severe heterogeneous emphysema
CONCLUSIONS: Our study found that patients with severe, heterogeneous emphysema who undergo ELVR utilizing Zephyr® EBV and suffer complications during post-procedure period are more likely to have CAD or T2DM as baseline comorbidity. These data suggest that baseline CAD and T2DM might be predictive of increased risk of complications following ELVR with EBV.PMID:34302313 | DOI:10.1111/crj.13426 (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Sebastian Fernandez-Bussy Anna Kornafeld Gonzalo Labarca David Abia-Trujillo Neal M Patel Margaret M Johnson Janani S Reisenauer Felix J Herth Source Type: research

Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial
In this study we first aimed to test the hypothesis that genetic variants in the IL-33 pathway were also associated with COPD. On the basis of the strong association of IL-33 pathway genes with pulmonary diseases like asthma and COPD, we conducted this phase 2a trial to assess the safety and efficacy of itepekimab in patients with moderate-to-severe COPD on a stable regimen of triple-inhaled or double-inhaled background maintenance therapy.METHODS: In this two-part study, genetic analyses of loss-of-function and gain-of-function variants in the IL-33 pathway, previously associated with asthma risk, were initially character...
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Klaus F Rabe Bartolome R Celli Michael E Wechsler Raolat M Abdulai Xiaodong Luo Maarten M Boomsma Heribert Staudinger Julie E Horowitz Aris Baras Manuel A Ferreira Marcella K Ruddy Michael C Nivens Nikhil Amin David M Weinreich George D Yancopoulos Helene Source Type: research

Whole blood gene expression signature in patients with obstructive sleep apnea and effect of continuous positive airway pressure treatment
Respir Physiol Neurobiol. 2021 Jul 21:103746. doi: 10.1016/j.resp.2021.103746. Online ahead of print.ABSTRACTThe molecular mechanisms of obstructive sleep apnea (OSA), in particular the gene expression patterns in whole blood of patients with OSA, can shed more light on the underlying pathophysiology of OSA and suggest potential biomarkers. In the current study, we have enrolled thirty patients with untreated moderate-severe OSA together with 20 BMI, age, and sex-matched controls and 15 normal-weight controls. RNA-sequencing of whole blood and home sleep apnea testing were performed in the untreated state and after three a...
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Eva Christensson Souren Mkrtchian Anette Ebberyd Åsa Österlund Modalen Karl A Franklin Lars I Eriksson Malin Jonsson Fagerlund Source Type: research

Single-inhaler triple vs single-inhaler dual therapy in patients with chronic obstructive pulmonary disease: a meta-analysis of randomized control trials
CONCLUSIONS: This meta-analysis suggests that single-inhaler triple therapy is effective in reducing the risk of death of any cause and of moderate or severe exacerbation in COPD patients. However, the risk of pneumonia is higher with ICS/LAMA/LABA FDC than with LABA/LAMA FDC. Trial registration PROSPERO #CRD42020186726.PMID:34301267 | DOI:10.1186/s12931-021-01794-w (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Huanyu Long Hongxuan Xu Jean-Paul Janssens Yanfei Guo Source Type: research

The challenge of asthma control grading in clinical practice
Respir Investig. 2021 Jul 20:S2212-5345(21)00109-X. doi: 10.1016/j.resinv.2021.06.001. Online ahead of print.ABSTRACTAsthma is a chronic disease for which control is considered the management goal. However, the different methods to measure asthma control, including the Global Initiative for Asthma (GINA) criteria and Asthma Control Test (ACT), can produce conflicting results. This nationwide pediatric study compared both methods in 465 enrolled children (322 males, mean age 11.2 years). Lung function and symptom perception were also evaluated. The results showed fair concordance (k = 0.253) between GINA grading and childho...
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Maria Angela Tosca Irene Schiavetti Giorgio Ciprandi “ControL’Asma” Study Group Source Type: research

Low utilisation of bronchoscopy to assess COVID-19 respiratory infection: a multicenter experience
CONCLUSIONS: BAL was used infrequently to assess COVID-19 in busy institutions. NP swabs have a high concordance with BAL for COVID-19 testing, but negative NP swabs should be confirmed with BAL when clinical suspicion is high.PMID:34301713 | DOI:10.1136/bmjresp-2021-000962 (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Kamran Mahmood Matt Abbott Keriann Van Nostrand Rabih Bechara Anne V Gonzalez Amanda Brucker Cynthia L Green Christopher R Polage Source Type: research

Adverse Events of Prone Positioning in Mechanically Ventilated Adults with Acute Respiratory Distress Syndrome
CONCLUSIONS: We identified>40 adverse events reported in prone positioning ARDS studies, involving additional AEs not yet reported by previous systematic reviews. The pooled adverse event proportions collected in this review could guide research and clinical practice decisions, and the strategies to mitigate adverse events could promote future consensus-based recommendations.PMID:34301802 | DOI:10.4187/respcare.09194 (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Felipe Gonz ález-Seguel Juan Jos é Pinto-Concha Nadine Aranis Jaime Leppe Source Type: research

Intraoperative Ventilation in the High-Risk Surgical Patient
Respir Care. 2021 Aug;66(8):1337-1340. doi: 10.4187/respcare.09170.ABSTRACTPostoperative pulmonary complications contribute to perioperative morbidity and mortality in addition to being associated with increased health care costs. In this review article, we outline risk factors for the development postoperative pulmonary complications, describe their impact on perioperative outcomes, and focus on the role of intraoperative ventilation strategies in decreasing postoperative pulmonary complications.PMID:34301857 | DOI:10.4187/respcare.09170 (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Angela Meier Diana Hylton Ulrich H Schmidt Source Type: research

Creating a Process of Research in Respiratory Care
Respir Care. 2021 Aug;66(8):1363-1364. doi: 10.4187/respcare.09367.NO ABSTRACTPMID:34301858 | DOI:10.4187/respcare.09367 (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Richard D Branson Richard H Kallet Source Type: research

Under Pressure: Risks for Injury During Pediatric Noninvasive Ventilation
Respir Care. 2021 Aug;66(8):1365. doi: 10.4187/respcare.09392.NO ABSTRACTPMID:34301859 | DOI:10.4187/respcare.09392 (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Shinya Miura Atsushi Kawaguchi Atsushi Kawaguchi Source Type: research

Is Delivery of Aerosolized Medication via HFNC for Critical Asthma Effective Concurrent Therapy?
Respir Care. 2021 Aug;66(8):1366-1367. doi: 10.4187/respcare.09410.NO ABSTRACTPMID:34301860 | DOI:10.4187/respcare.09410 (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Natalie Napolitano Source Type: research

F < sub > IO < sub > 2 < /sub > < /sub > , P < sub > aO < sub > 2 < /sub > < /sub > , or Else - What Matters in Noninvasive Ventilation in Stable COPD?
Respir Care. 2021 Aug;66(8):1368-1370. doi: 10.4187/respcare.08560.NO ABSTRACTPMID:34301861 | DOI:10.4187/respcare.08560 (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Irena Sarc Kristina Ziherl Antonio M Esquinas Source Type: research

Reply to: F < sub > IO < sub > 2 < /sub > < /sub > , P < sub > aO < sub > 2 < /sub > < /sub > , or Else - What Matters in Noninvasive Ventilation in Stable COPD?
Respir Care. 2021 Aug;66(8):1369-1370. doi: 10.4187/respcare.09172.NO ABSTRACTPMID:34301862 | DOI:10.4187/respcare.09172 (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Michael Cardinale Pierre-Julien Cungi Pierre Esnault Eric Meaudre Philippe Goutorbe Source Type: research

Editor's Commentary
Respir Care. 2021 Aug;66(8):i.NO ABSTRACTPMID:34301863 (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Source Type: research

Risk of complications rise with coronary artery disease and diabetes mellitus after endobronchial valve placement in severe heterogeneous emphysema
CONCLUSIONS: Our study found that patients with severe, heterogeneous emphysema who undergo ELVR utilizing Zephyr® EBV and suffer complications during post-procedure period are more likely to have CAD or T2DM as baseline comorbidity. These data suggest that baseline CAD and T2DM might be predictive of increased risk of complications following ELVR with EBV.PMID:34302313 | DOI:10.1111/crj.13426 (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Sebastian Fernandez-Bussy Anna Kornafeld Gonzalo Labarca David Abia-Trujillo Neal M Patel Margaret M Johnson Janani S Reisenauer Felix J Herth Source Type: research

Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial
In this study we first aimed to test the hypothesis that genetic variants in the IL-33 pathway were also associated with COPD. On the basis of the strong association of IL-33 pathway genes with pulmonary diseases like asthma and COPD, we conducted this phase 2a trial to assess the safety and efficacy of itepekimab in patients with moderate-to-severe COPD on a stable regimen of triple-inhaled or double-inhaled background maintenance therapy.METHODS: In this two-part study, genetic analyses of loss-of-function and gain-of-function variants in the IL-33 pathway, previously associated with asthma risk, were initially character...
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Klaus F Rabe Bartolome R Celli Michael E Wechsler Raolat M Abdulai Xiaodong Luo Maarten M Boomsma Heribert Staudinger Julie E Horowitz Aris Baras Manuel A Ferreira Marcella K Ruddy Michael C Nivens Nikhil Amin David M Weinreich George D Yancopoulos Helene Source Type: research

Whole blood gene expression signature in patients with obstructive sleep apnea and effect of continuous positive airway pressure treatment
Respir Physiol Neurobiol. 2021 Jul 21:103746. doi: 10.1016/j.resp.2021.103746. Online ahead of print.ABSTRACTThe molecular mechanisms of obstructive sleep apnea (OSA), in particular the gene expression patterns in whole blood of patients with OSA, can shed more light on the underlying pathophysiology of OSA and suggest potential biomarkers. In the current study, we have enrolled thirty patients with untreated moderate-severe OSA together with 20 BMI, age, and sex-matched controls and 15 normal-weight controls. RNA-sequencing of whole blood and home sleep apnea testing were performed in the untreated state and after three a...
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Eva Christensson Souren Mkrtchian Anette Ebberyd Åsa Österlund Modalen Karl A Franklin Lars I Eriksson Malin Jonsson Fagerlund Source Type: research

The complexity of mental health care for people with COPD: a qualitative study of clinicians' perspectives
NPJ Prim Care Respir Med. 2021 Jul 22;31(1):40. doi: 10.1038/s41533-021-00252-w.ABSTRACTAnxiety and depression are common mental health illnesses in people with chronic obstructive pulmonary disease (COPD). However, patients often decline formal mental health care with barriers identified at the patient, health provider and health system levels. Currently clinicians' perspectives on this issue are not well understood. A qualitative study using semi-structured interviews was undertaken to explore clinician perceived barriers and facilitators to acceptance of psychological care amongst people with COPD. Twenty-four Australia...
Source: Respiratory Care - July 23, 2021 Category: Respiratory Medicine Authors: Juliet Wang Karen Willis Elizabeth Barson Natasha Smallwood Source Type: research

Machine Learning-based Sleep Staging in Sleep Apnea Patients Using a Single Mandibular Movement Signal
Am J Respir Crit Care Med. 2021 Jul 23. doi: 10.1164/rccm.202103-0680LE. Online ahead of print.NO ABSTRACTPMID:34297641 | DOI:10.1164/rccm.202103-0680LE (Source: Respiratory Care)
Source: Respiratory Care - July 23, 2021 Category: Respiratory Medicine Authors: Nhat-Nam Le-Dong Jean-Benoit Martinot Nathalie Coumans Val érie Cuthbert Renaud Tamisier S ébastien Bailly Jean-Louis P épin Source Type: research

The complexity of mental health care for people with COPD: a qualitative study of clinicians' perspectives
NPJ Prim Care Respir Med. 2021 Jul 22;31(1):40. doi: 10.1038/s41533-021-00252-w.ABSTRACTAnxiety and depression are common mental health illnesses in people with chronic obstructive pulmonary disease (COPD). However, patients often decline formal mental health care with barriers identified at the patient, health provider and health system levels. Currently clinicians' perspectives on this issue are not well understood. A qualitative study using semi-structured interviews was undertaken to explore clinician perceived barriers and facilitators to acceptance of psychological care amongst people with COPD. Twenty-four Australia...
Source: Respiratory Care - July 23, 2021 Category: Respiratory Medicine Authors: Juliet Wang Karen Willis Elizabeth Barson Natasha Smallwood Source Type: research

Machine Learning-based Sleep Staging in Sleep Apnea Patients Using a Single Mandibular Movement Signal
Am J Respir Crit Care Med. 2021 Jul 23. doi: 10.1164/rccm.202103-0680LE. Online ahead of print.NO ABSTRACTPMID:34297641 | DOI:10.1164/rccm.202103-0680LE (Source: Respiratory Care)
Source: Respiratory Care - July 23, 2021 Category: Respiratory Medicine Authors: Nhat-Nam Le-Dong Jean-Benoit Martinot Nathalie Coumans Val érie Cuthbert Renaud Tamisier S ébastien Bailly Jean-Louis P épin Source Type: research

Physical activity, sedentary behavior, and incidence of obstructive sleep apnea in three prospective US cohorts
Eur Respir J. 2021 Jul 21:2100606. doi: 10.1183/13993003.00606-2021. Online ahead of print.ABSTRACTReduced physical activity and increased sedentary behavior may independently contribute to development of obstructive sleep apnea (OSA) through increased adiposity, inflammation, insulin resistance and body fluid retention. However, epidemiologic evidence remains sparse, and is primarily limited to cross-sectional studies.We prospectively followed 50 332 women from the Nurses' Health Study (2002-2012), 68 265 women from the Nurses' Health Study II (1995-2013), and 19 320 men from the Health Professionals Follow-up Study (1996...
Source: Respiratory Care - July 22, 2021 Category: Respiratory Medicine Authors: Yue Liu Lin Yang Meir J Stampfer Susan Redline Shelley S Tworoger Tianyi Huang Source Type: research

Ventilatory efficiency in pulmonary vascular diseases
Eur Respir Rev. 2021 Jul 20;30(161):200214. doi: 10.1183/16000617.0214-2020. Print 2021 Sep 30.ABSTRACTCardiopulmonary exercise testing (CPET) is a frequently used tool in the differential diagnosis of dyspnoea. Ventilatory inefficiency, defined as high minute ventilation (V' E) relative to carbon dioxide output (V' CO2 ), is a hallmark characteristic of pulmonary vascular diseases, which contributes to exercise intolerance and disability in these patients. The mechanisms of ventilatory inefficiency are multiple and include high physiologic dead space, abnormal chemosensitivity and an altered carbon dioxide (CO2) set-point...
Source: Respiratory Care - July 22, 2021 Category: Respiratory Medicine Authors: Jason Weatherald Brianne Philipenko David Montani Pierantonio Laveneziana Source Type: research

Impact of ageing and pregnancy on the minute ventilation/carbon dioxide production response to exercise
Eur Respir Rev. 2021 Jul 20;30(161):200225. doi: 10.1183/16000617.0225-2020. Print 2021 Sep 30.ABSTRACTVentilatory efficiency can be evaluated using the relationship between minute ventilation (V'E) and the rate of CO2 production (V'CO2 ). In accordance with the modified alveolar ventilation equation, this relationship is determined by changes in dead space volume (V D) and/or the arterial CO2 tension (P aCO2 ) equilibrium point. In this review, we summarise the physiological factors that may account for normative ageing and pregnancy induced increases in V'E/V'CO2 during exercise. Evidence suggests that age-related increa...
Source: Respiratory Care - July 22, 2021 Category: Respiratory Medicine Authors: Michele R Schaeffer Jordan A Guenette Dennis Jensen Source Type: research

Update on molecular pathology and role of liquid biopsy in nonsmall cell lung cancer
Eur Respir Rev. 2021 Jul 20;30(161):200294. doi: 10.1183/16000617.0294-2020. Print 2021 Sep 30.ABSTRACTPersonalised medicine, an essential component of modern thoracic oncology, has been evolving continuously ever since the discovery of the epidermal growth factor receptor and its tyrosine kinase inhibitors. Today, screening for driver alterations in patients with advanced lung adenocarcinoma as well as those with squamous cell carcinoma and no/little history of smoking is mandatory. Multiplex molecular platforms are preferred to sequential molecular testing since they are less time- and tissue-consuming. In this review, w...
Source: Respiratory Care - July 22, 2021 Category: Respiratory Medicine Authors: Pamela Abdayem David Planchard Source Type: research

Combined non-invasive respiratory support therapies to treat SARS-CoV-2 patients: A prospective Observational Study
Conclusions: Data from our cohort managed on RICU showed that combined NIRS are feasible with favorable outcomes. Further prospective studies are required.PMID:34290078 | DOI:10.4187/respcare.09162 (Source: Respiratory Care)
Source: Respiratory Care - July 22, 2021 Category: Respiratory Medicine Authors: Nicolas Colaianni-Alfonso Guillermo Montiel Mauro Castro-Sayat Catalina Siroti Maria Laura Vega Ada Toledo Santiago Haedo Ignacio Previgliano Guido Mazzinari Jos é Miguel Alonso-Íñigo Source Type: research

A review of respiratory manifestations and their management in Ehlers-Danlos syndromes and hypermobility spectrum disorders
CONCLUSION: Respiratory symptoms and manifestations are described in EDS and HSD, and have generally been managed using conservative non-surgical strategies. Research into the prevalence, incidence and specific respiratory management strategies in EDS and HSD is needed to mitigate some of the associated morbidity.PMID:34291699 | DOI:10.1177/14799731211025313 (Source: Respiratory Care)
Source: Respiratory Care - July 22, 2021 Category: Respiratory Medicine Authors: Karan Chohan Nimish Mittal Laura McGillis Laura Lopez-Hernandez Encarna Camacho Maxim Rachinsky Daniel Santa Mina W Darlene Reid Clodagh Mai Ryan Kateri Agnes Champagne Ani Orchanian-Cheff Hance Clarke Dmitry Rozenberg Source Type: research

Physical activity, sedentary behavior, and incidence of obstructive sleep apnea in three prospective US cohorts
Eur Respir J. 2021 Jul 21:2100606. doi: 10.1183/13993003.00606-2021. Online ahead of print.ABSTRACTReduced physical activity and increased sedentary behavior may independently contribute to development of obstructive sleep apnea (OSA) through increased adiposity, inflammation, insulin resistance and body fluid retention. However, epidemiologic evidence remains sparse, and is primarily limited to cross-sectional studies.We prospectively followed 50 332 women from the Nurses' Health Study (2002-2012), 68 265 women from the Nurses' Health Study II (1995-2013), and 19 320 men from the Health Professionals Follow-up Study (1996...
Source: Respiratory Care - July 22, 2021 Category: Respiratory Medicine Authors: Yue Liu Lin Yang Meir J Stampfer Susan Redline Shelley S Tworoger Tianyi Huang Source Type: research

Ventilatory efficiency in pulmonary vascular diseases
Eur Respir Rev. 2021 Jul 20;30(161):200214. doi: 10.1183/16000617.0214-2020. Print 2021 Sep 30.ABSTRACTCardiopulmonary exercise testing (CPET) is a frequently used tool in the differential diagnosis of dyspnoea. Ventilatory inefficiency, defined as high minute ventilation (V' E) relative to carbon dioxide output (V' CO2 ), is a hallmark characteristic of pulmonary vascular diseases, which contributes to exercise intolerance and disability in these patients. The mechanisms of ventilatory inefficiency are multiple and include high physiologic dead space, abnormal chemosensitivity and an altered carbon dioxide (CO2) set-point...
Source: Respiratory Care - July 22, 2021 Category: Respiratory Medicine Authors: Jason Weatherald Brianne Philipenko David Montani Pierantonio Laveneziana Source Type: research

Impact of ageing and pregnancy on the minute ventilation/carbon dioxide production response to exercise
Eur Respir Rev. 2021 Jul 20;30(161):200225. doi: 10.1183/16000617.0225-2020. Print 2021 Sep 30.ABSTRACTVentilatory efficiency can be evaluated using the relationship between minute ventilation (V'E) and the rate of CO2 production (V'CO2 ). In accordance with the modified alveolar ventilation equation, this relationship is determined by changes in dead space volume (V D) and/or the arterial CO2 tension (P aCO2 ) equilibrium point. In this review, we summarise the physiological factors that may account for normative ageing and pregnancy induced increases in V'E/V'CO2 during exercise. Evidence suggests that age-related increa...
Source: Respiratory Care - July 22, 2021 Category: Respiratory Medicine Authors: Michele R Schaeffer Jordan A Guenette Dennis Jensen Source Type: research

Update on molecular pathology and role of liquid biopsy in nonsmall cell lung cancer
Eur Respir Rev. 2021 Jul 20;30(161):200294. doi: 10.1183/16000617.0294-2020. Print 2021 Sep 30.ABSTRACTPersonalised medicine, an essential component of modern thoracic oncology, has been evolving continuously ever since the discovery of the epidermal growth factor receptor and its tyrosine kinase inhibitors. Today, screening for driver alterations in patients with advanced lung adenocarcinoma as well as those with squamous cell carcinoma and no/little history of smoking is mandatory. Multiplex molecular platforms are preferred to sequential molecular testing since they are less time- and tissue-consuming. In this review, w...
Source: Respiratory Care - July 22, 2021 Category: Respiratory Medicine Authors: Pamela Abdayem David Planchard Source Type: research