Coinfection with Pseudomonas aeruginosa and Aspergillus fumigatus in cystic fibrosis.
CONCLUSION: A complex bi-directional relationship exists between P. aeruginosa and A. fumigatus, exhibiting both mutually antagonistic and cooperative facets. Cross-sectional data indicate a worsened disease state in coinfected patients; however, robust longitudinal studies are required to derive causality and to determine whether interspecies interaction contributes to disease progression. PMID: 33208485 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - November 20, 2020 Category: Respiratory Medicine Authors: Keown K, Reid A, Moore JE, Taggart CC, Downey DG Tags: Eur Respir Rev Source Type: research

Design of pulmonary rehabilitation programmes during acute exacerbations of COPD: a systematic review and network meta-analysis.
Abstract This systematic review aimed to systematise the different designs used to deliver pulmonary rehabilitation during acute exacerbations of COPD (AECOPD) and explore which ones are the most effective. PubMed, Scopus, Web of Science, EBSCO and Cochrane were searched. Randomised controlled trials comparing pulmonary rehabilitation or at least one of its components with usual care or comparing different components of pulmonary rehabilitation were included. Network meta-analysis was conducted in MetaXL 5.3 using a generalised pairwise modelling framework. Pooled effects compared each treatment to usual care. 42 ...
Source: Respiratory Care - November 20, 2020 Category: Respiratory Medicine Authors: Machado A, Matos Silva P, Afreixo V, Caneiras C, Burtin C, Marques A Tags: Eur Respir Rev Source Type: research

Bronchoscopic treatment of inoperable nonsmall cell lung cancer.
Abstract Patients with unresectable lung cancer range from those with early-stage or pre-invasive disease with comorbidities that preclude surgery to those with advanced stage disease in whom surgery is contraindicated. In such cases, a multidisciplinary approach to treatment is warranted, and may involve medical specialties including medical oncology, radiation oncology and interventional pulmonology. In this article we review bronchoscopic approaches to surgically unresectable lung cancer, including photodynamic therapy, brachytherapy, endoscopic ablation techniques and airway stenting. Current and past literatu...
Source: Respiratory Care - November 10, 2020 Category: Respiratory Medicine Authors: Kniese CM, Musani AI Tags: Eur Respir Rev Source Type: research

Management of tracheo-oesophageal fistula in adults.
Abstract Tracheo-oesophageal fistula (TOF) is a pathological connection between the trachea and the oesophagus that is associated with various underlying conditions including malignancies, infections, inhalation injuries and traumatic damage. As the condition spans multiple organ systems with varying aetiologies and acuities, TOF poses unique diagnostic and management challenges to pulmonologists, gastroenterologists and thoracic surgeons alike. Although stents have been a cornerstone in the management of TOF, there exists a large gap in our understanding of their efficacy and precise methodology, making stenting ...
Source: Respiratory Care - November 10, 2020 Category: Respiratory Medicine Authors: Kim HS, Khemasuwan D, Diaz-Mendoza J, Mehta AC Tags: Eur Respir Rev Source Type: research

The effects of lung volume reduction treatment on diffusing capacity and gas exchange.
Abstract Lung volume reduction (LVR) treatment in patients with severe emphysema has been shown to have a positive effect on hyperinflation, expiratory flow, exercise capacity and quality of life. However, the effects on diffusing capacity of the lungs and gas exchange are less clear. In this review, the possible mechanisms by which LVR treatment can affect diffusing capacity of the lung for carbon monoxide (D LCO) and arterial gas parameters are discussed, the use of D LCO in LVR treatment is evaluated and other diagnostic techniques reflecting diffusing capacity and regional ventilation (V')/perfusion (Q') misma...
Source: Respiratory Care - October 30, 2020 Category: Respiratory Medicine Authors: van Dijk M, Klooster K, Ten Hacken NHT, Sciurba F, Kerstjens HAM, Slebos DJ Tags: Eur Respir Rev Source Type: research

Unsolved Mysteries: High-Frequency Jet Ventilation in the Neonatal ICU.
PMID: 33099485 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - October 27, 2020 Category: Respiratory Medicine Authors: Miller AG, Bartle RM Tags: Respir Care Source Type: research

Administering Inhaled Nitric Oxide: Still More to Understand.
PMID: 33099486 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - October 27, 2020 Category: Respiratory Medicine Authors: Betit P, Wheeler CR, Liu J Tags: Respir Care Source Type: research

Decreasing Unplanned Extubations in the Neonatal ICU.
PMID: 33099487 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - October 27, 2020 Category: Respiratory Medicine Authors: Lauderbaugh DL, Sutherland KM Tags: Respir Care Source Type: research

Editor's Commentary.
Authors: PMID: 33099488 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - October 27, 2020 Category: Respiratory Medicine Tags: Respir Care Source Type: research

The Use of a Novel Quantitative Marker of Echogenicity of Pleural Fluid in Parapneumonic Pleural Effusions.
Abstract Background: Thoracic ultrasound is an essential tool in the daily clinical care of pleural effusions and especially parapneumonic pleural effusions (PPEs), in terms of diagnosis, management, and follow-up. Hypoechogenicity index (HI) is a quantitative marker of pleural fluid echogenicity. We aimed to examine associations of HI with pleural inflammation in patients with PPE. Methods: All patients included underwent a thoracic ultrasound with HI determination at the first day of their admission for a PPE. Thoracentesis was performed in all patients. Demographics, laboratory measurements, and clinical d...
Source: Respiratory Care - October 23, 2020 Category: Respiratory Medicine Authors: Varsamas C, Kalkanis A, Gourgoulianis KI, Malli F Tags: Can Respir J Source Type: research

The Outcome of Hydroxychloroquine in Patients Treated for COVID-19: Systematic Review and Meta-Analysis.
Conclusion: This meta-analysis and systematic review, which included a limited number of poorly designed studies of patients with COVID-19, revealed HCQ is intolerable, unsafe, and not efficacious. Similarly, HCQ + AZ combination was not different from HCQ alone in curbing mortality and ICU admission. PMID: 33082891 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - October 23, 2020 Category: Respiratory Medicine Authors: Ayele Mega T, Feyissa TM, Dessalegn Bosho D, Kumela Goro K, Zeleke Negera G Tags: Can Respir J Source Type: research

A case of post adenoviral bronchiectasis being managed at home with humidified high flow nasal cannula (HHFNC).
Abstract Human adenovirus is an important cause of febrile illness affecting mainly respiratory system ranging from pharyngitis, coryza to fatal pneumonia. Though most of the infections are trivial and results in complete recovery but it may result in considerable morbidities and mortalities in selected patients who developed severe adenoviral infections especially Pneumonia(ADVP)/Lower respiratory tract infection(LRTI). Severe adenoviral pneumonia is notorious to produce long term sequelae in the form of post infectious bronchiolitis obliterans (PIBO) or even bronchiectasis. Here we present a case of a ten months...
Source: Respiratory Care - October 23, 2020 Category: Respiratory Medicine Authors: Singh D, Rajbanshi A, Giri PP Tags: Respir Med Case Rep Source Type: research

Acute high-risk pulmonary embolism requiring thrombolytic therapy in a COVID-19 pneumonia patient despite intermediate dosing deep vein thromboprophylaxis.
Abstract Cytokine storm induced by the coronavirus 19 (COVID-19) profoundly activates the coagulation cascade causing venous thromboembolism (VTE). Initial studies from Wuhan, China showed increased incidence of VTE in patients with no standard deep vein thrombosis (DVT) prophylaxis in COVID-19 pneumonia patients. Few have argued for high intensity or intermediate DVT prophylaxis in COVID-19 patients with the incidence of VTE ranging from 16 to 27% despite standard DVT prophylaxis. However, no guideline recommendations presently exist to prescribe augmented DVT prophylaxis in these patients due to lack of evidence...
Source: Respiratory Care - October 23, 2020 Category: Respiratory Medicine Authors: Salam S, Mallat J, Elkambergy H Tags: Respir Med Case Rep Source Type: research

Converging pathways in pulmonary fibrosis and Covid-19 - The fibrotic link to disease severity.
horsson G Abstract As Covid-19 affects millions of people worldwide, the global health care will encounter an increasing burden of the aftermaths of the disease. Evidence shows that up to a fifth of the patients develop fibrotic tissue in the lung. The SARS outbreak in the early 2000 resulted in chronic pulmonary fibrosis in a subset (around 4%) of the patients, and correlated to reduced lung function and forced expiratory volume (FEV). The similarities between corona virus infections causing SARS and Covid-19 are striking, except that the novel coronavirus, SARS-CoV-2, has proven to have an even higher communicab...
Source: Respiratory Care - October 23, 2020 Category: Respiratory Medicine Authors: Wigén J, Löfdahl A, Bjermer L, Elowsson-Rendin L, Westergren-Thorsson G Tags: Respir Med X Source Type: research

The Role of Granzyme B Containing Cells in the Progression of Chronic Obstructive Pulmonary Disease.
Abstract Background: Lung inflammation plays a vital role in the pathogenesis of chronic obstructive pulmonary disease (COPD), but the characteristics of the inflammatory process remains unclear. There is growing interest in the role of granzyme B (GzmB) because CD8+ T cells can induce apoptosis of target cells by releasing GzmB, which in turn may cause tissue injury and remodeling. However, GzmB is also expressed by regulatory cells, which are able to suppress CD8+ T cell. The role of GzmB+ cells needs to be defined in COPD. Methods: GzmB+ and CD8+ cells on alveolar wall of surgically resected lungs of micro...
Source: Respiratory Care - October 20, 2020 Category: Respiratory Medicine Authors: Kim WD, Chi HS, Choe KH, Kim WS, Hogg JC, Sin DD Tags: Tuberc Respir Dis (Seoul) Source Type: research

Lung Myofibroblast Promote Macrophage Pro-fibrotic Activity Through Lactate-induced Histone Lactylation.
Abstract Augmented glycolysis due to metabolic reprogramming in lung myofibroblasts is critical to their pro-fibrotic phenotype. The primary glycolysis byproduct, lactate, is also secreted into the extracellular milieu, together with which, myofibroblasts and macrophages form a spatially restricted site usually described as fibrotic niche. Therefore, we hypothesized that myofibroblast glycolysis might have a non-cell autonomous effect through lactate regulating the pathogenic phenotype of alveolar macrophages. Here, we demonstrated that there was a markedly increased lactate in the conditioned media of TGF-β1...
Source: Respiratory Care - October 19, 2020 Category: Respiratory Medicine Authors: Cui H, Xie N, Banerjee S, Ge J, Jiang D, Dey T, Matthews QL, Liu RM, Liu G Tags: Am J Respir Cell Mol Biol Source Type: research

Variability of forced vital capacity in progressive interstitial lung disease: a prospective observational study.
CONCLUSIONS: Daily home spirometry is feasible in IPF and non-IPF ILD and facilitates the identification of FVC variability, which was associated with disease progression. PMID: 33076914 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - October 19, 2020 Category: Respiratory Medicine Authors: Veit T, Barnikel M, Crispin A, Kneidinger N, Ceelen F, Arnold P, Munker D, Schmitzer M, Barton J, Schiopu S, Schiller HB, Frankenberger M, Milger K, Behr J, Neurohr C, Leuschner G Tags: Respir Res Source Type: research

Long-term clinical course and outcomes of immunoglobulin G4-related lung disease.
CONCLUSIONS: Most patients showed a favorable outcome with regards to radiologic improvement and maintenance of pulmonary function; however, the response differed according to the radiologic subtype. PMID: 33076916 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - October 19, 2020 Category: Respiratory Medicine Authors: Kang J, Park S, Chae EJ, Song JS, Hwang HS, Kim SJ, Song TJ, Kim MW, Song JW Tags: Respir Res Source Type: research

Fluid Balance Predicts Need for Intubation in Patients with Respiratory Failure Initiated on High Flow Nasal Cannula.
Abstract BACKGROUND: High Flow Nasal Cannula (HFNC) has gained widespread use for acute hypoxemic respiratory failure on the basis of recent publications demonstrating fewer intubations and perhaps lower mortality in certain situations. However, a subset of patients initiated on HFNC for respiratory failure ultimately do require intubation. Our goal is to identify patient level features predictive of this outcome. MATERIALS AND METHODS: This is a retrospective cohort study of patients with hypoxemic respiratory failure treated with HFNC. Individuals were described as having "succeeded" (if weaned fr...
Source: Respiratory Care - October 19, 2020 Category: Respiratory Medicine Authors: Varipapa RJ, DiGiacomo E, Jamieson DB, Desale S, Sonti R Tags: Respir Care Source Type: research

Design and performance testing of a novel emergency ventilator for in-hospital use.
Abstract Background: The rapidly evolving COVID-19 pandemic has led to increased use of critical care resources, particularly mechanical ventilators. Amidst growing concerns that the health care system could face a shortage of ventilators in the future, there is a need for an affordable, simple, easy to use, emergency stockpile ventilator. Methods: Our team of engineers and clinicians designed and tested an emergency ventilator that uses a single limb portable ventilator circuit. The circuit is controlled by a pneumatic signal with electronic microcontroller input, using air and oxygen sources found in standa...
Source: Respiratory Care - October 16, 2020 Category: Respiratory Medicine Authors: Knorr JM, Sheehan MM, Santana DC, Samorezov S, Sammour I, Deblock M, Kuban B, Chaisson N, Chatburn RL Tags: Can J Respir Ther Source Type: research

Clinical characteristics and changes of clinical features in patients with asthma-COPD overlap in Korea according to different diagnostic criteria.
Conclusion: In the present study, prevalence and clinical characteristics of ACO varied depending on the diagnostic criteria applied. PMID: 33045813 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - October 13, 2020 Category: Respiratory Medicine Authors: Lim JU, Kim DK, Lee MG, Hwang YI, Shin KC, In KH, Lee SY, Rhee CK, Yoo KH, Yoon HK Tags: Tuberc Respir Dis (Seoul) Source Type: research

Implications of managing Chronic Obstructive Pulmonary Disease (COPD) in Cardiovascular Diseases.
This study aimed at summarizing the current knowledge regarding the prevalence of COPD in heart failure, ischemic heart disease, and atrial fibrillation. We have also discussed the real-life clinical presentation and practical implications of managing COPD in cardiac diseases. We searched Pubmed, Scopus, EMBASE, and Google Scholar for studies published between 1981 to May 2020 reporting the prevalence of COPD in the three specified cardiac diseases. COPD has a high prevalence in heart failure, atrial fibrillation, and ischemic heart disease. Despite this, COPD remains under-diagnosed and under-managed in the majority of pa...
Source: Respiratory Care - October 13, 2020 Category: Respiratory Medicine Authors: Deshmukh K, Khanna A Tags: Tuberc Respir Dis (Seoul) Source Type: research

Costs of a clinical pathway with point-of-care testing during influenza epidemic in a Dutch hospital.
Abstract Our study aim was to determine how a new clinical pathway, including PCR-based influenza point-of-care test (POCT), influences the hospitalisation costs of patients suspected of influenza presenting at the emergency department of a Dutch hospital during two consecutive influenza epidemics (2016-2017 and 2017-2018). Compared to mean costs per patient of €3661 in 2016-2017, the implementation of this new clinical pathway with influenza POCT in 2017 was associated with mean costs per influenza-positive patient of €2495 in 2017-2018 (P = .3). Our study suggests favourable economic results ...
Source: Respiratory Care - October 12, 2020 Category: Respiratory Medicine Authors: Marbus SD, Lutgens SPM, van Gageldonk-Lafeber AB, Hazenberg EHLCM, Hermans MHA, Suijkerbuijk AWM Tags: Influenza Other Respir Viruses Source Type: research

COVID-19 multidisciplinary high dependency unit: the Milan model.
Abstract COVID-19 is a complex and heterogeneous disease. The pathogenesis and the complications of the disease are not fully elucidated, and increasing evidence shows that SARS-CoV-2 causes a systemic inflammatory disease rather than a pulmonary disease. The management of hospitalized patients in COVID-19 dedicated units is advisable for segregation purpose as well as for infection control. In this article we present the standard operating procedures of our COVID-19 high dependency unit of the Policlinico Hospital, in Milan. Our high dependency unit is based on a multidisciplinary approach. We think that the mult...
Source: Respiratory Care - October 9, 2020 Category: Respiratory Medicine Authors: Aliberti S, Amati F, Pappalettera M, Di Pasquale M, D'Adda A, Mantero M, Gramegna A, Simonetta E, Oneta AM, Privitera E, Gori A, Bozzi G, Peyvandi F, Minoia F, Filocamo G, Abbruzzese C, Vicenzi M, Tagliabue P, Alongi S, Blasi F Tags: Respir Res Source Type: research

Functional analysis and evaluation of respiratory cilia in healthy Chinese children.
CONCLUSIONS: We established the reference range for CBF, beat pattern and ultrastructure in healthy Chinese children. Using similar methodology, we found a lower overall mean CBF than previously obtained European values. This study highlights the need to establish normative data for ciliary function in different populations. PMID: 33036612 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - October 9, 2020 Category: Respiratory Medicine Authors: Lee SL, O'Callaghan C, Lau YL, Lee CD Tags: Respir Res Source Type: research

Procalcitonin and lung ultrasound algorithm to diagnose severe pneumonia in critical paediatric patients (PROLUSP study). A randomised clinical trial.
CONCLUSION: This algorithm will help us to diagnose bacterial pneumonia and to prescribe the correct antibiotic treatment. A reduction of antibiotics per patient, of the treatment length, and of the exposure to ionizing radiation and in costs is expected. TRIAL REGISTRATION: NCT04217980 . PMID: 33032612 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - October 8, 2020 Category: Respiratory Medicine Authors: Rodríguez-Fanjul J, Guitart C, Bobillo-Perez S, Balaguer M, Jordan I Tags: Respir Res Source Type: research

European Respiratory Society Statement on Thoracic Ultrasound.
Abstract Thoracic ultrasound is increasingly considered to be an essential tool for the pulmonologist. It is used in diverse clinical scenarios, including as an adjunct to clinical decision making for diagnosis, a real-time guide to procedures, and a predictor or measurement of treatment response. The aim of this European Respiratory Society task force was to produce a statement on thoracic ultrasound for pulmonologists using thoracic ultrasound within the field of respiratory medicine. The multidisciplinary panel performed a review of the literature, addressing major areas of thoracic ultrasound practice and appl...
Source: Respiratory Care - October 8, 2020 Category: Respiratory Medicine Authors: Laursen CB, Clive A, Hallifax R, Pietersen PI, Asciak R, Davidsen JR, Bhatnagar R, Bedawi EO, Jacobsen N, Coleman C, Edey A, Via G, Volpicelli G, Massard G, Raimondi F, Evison M, Konge L, Annema J, Rahman NM, Maskell N Tags: Eur Respir J Source Type: research

Continuous positive airway pressure in Covid-19 patients with moderate-to-severe respiratory failure.
PMID: 33033151 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - October 8, 2020 Category: Respiratory Medicine Authors: Brusasco C, Corradi F, Di Domenico A, Raggi F, Timossi G, Santori G, Brusasco V, Galliera CPAP-Covid-19 study group Tags: Eur Respir J Source Type: research

The Effects of Chronic Intermittent Hypoxia in Bleomycin-induced lung injury on Pulmonary Fibrosis via Regulating the NF- κB/Nrf2 Signaling Pathway.
Conclusion: CIH accelerated lung fibrosis in BLE-induced lung injury in mice, potentially by regulating the NF-κB/Nrf2 signaling pathway. Our results implicate PF as a potential therapeutic agent for treating pulmonary fibrosis in individuals with OSA and idiopathic pulmonary fibrosis. PMID: 33027868 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - October 8, 2020 Category: Respiratory Medicine Authors: Kang HH, Kim IK, Yeo CD, Kim SW, Lee HY, Im JH, Kwon HY, Lee SH Tags: Tuberc Respir Dis (Seoul) Source Type: research

Percutaneous tracheostomy in COVID-19 patients: The Miami model.
Abstract The surge in critically ill patients requiring mechanical ventilation fueled by the COVID-19 pandemic has strained healthcare systems globally. With the increasing need for critical care resources, tracheostomy can facilitate weaning from mechanical ventilation and potentially increase availability of critical care resources. In this case series of three patients, we describe our technique for performing bedside percutaneous tracheostomy on patients with persistently positive SARS-CoV-2 real time polymerase chain reaction (RT-PCR). We hope to provide proceduralists with a specific method for percutaneous ...
Source: Respiratory Care - October 7, 2020 Category: Respiratory Medicine Authors: Akkineni S, Adkinson BC, Arias S Tags: Respir Med Case Rep Source Type: research

Clinical Characteristics of Asymptomatic Patients with SARS-CoV-2 in Zhejiang: An Imperceptible Source of Infection.
In this study, epidemiological investigations were conducted in the Zhejiang province to understand the epidemiology and clinical characteristics of asymptomatic patients with COVID-19. Methods: This retrospective study was carried out on 22 asymptomatic patients and 234 symptomatic patients with COVID-19 who were hospitalized in Zhejiang Duodi Hospital from January 21 to March 16, 2020. The characteristics of epidemiology, demography, clinical manifestations, and laboratory data of mild patients were compared and analyzed. Results: The median age was 28 years in asymptomatic patients and 48 years in symptomatic ...
Source: Respiratory Care - October 4, 2020 Category: Respiratory Medicine Authors: Dai W, Chen X, Xu X, Leng Z, Yu W, Lin H, Li H, Lin J, Qiu Z, Dai Y Tags: Can Respir J Source Type: research

The Association Between Chronic Kidney Disease and New Onset Renal Replacement Therapy on the Outcome of COVID-19 Patients: A Meta-analysis.
Abstract Objective: The aim of the study was to evaluate the association between chronic kidney disease (CKD) and new onset renal replacement therapy (RRT) with the outcome of Coronavirus Disease 2019 (COVID-19) in patients. Methodology: A systematic literature search from several databases was performed on studies that assessed CKD, use of RRT, and the outcome of COVID-19. The composite of poor outcome consisted of mortality, severe COVID-19, acute respiratory distress syndrome (ARDS), need for intensive care, and use of mechanical ventilator. Results: Nineteen studies with a total of 7216 patients were...
Source: Respiratory Care - October 3, 2020 Category: Respiratory Medicine Authors: Pranata R, Supriyadi R, Huang I, Permana H, Lim MA, Yonas E, Soetedjo NNM, Lukito AA Tags: Clin Med Insights Circ Respir Pulm Med Source Type: research

Urine in the lung: An uncommon cause of transudative pleural effusion.
Abstract Urinothorax [UT], the accumulation of urine in the pleural space, is an uncommon cause of pleural effusions resulting from trauma, obstruction, or iatrogenic causes. Thoracentesis with pleural fluid analysis and evaluation of biochemical characteristics, such as pleural fluid creatinine (PCr) to serum creatinine ratio (Scr), is necessary to establish this diagnosis. This case illustrates a 93 year old man with a complicated past medical history including chronic kidney disease stage 4, adenocarcinoma of the prostate status post brachytherapy complicated by proctitis, high grade transitional cell carcinoma...
Source: Respiratory Care - October 3, 2020 Category: Respiratory Medicine Authors: Sullivan A, Lanham T, Bohra N, Ellis B, Kahn D Tags: Respir Med Case Rep Source Type: research

Tracheobronchopathia osteochondroplastica (TPO) associated with tracheobronchial amyloidosis (TBA).
Abstract Tracheobronchopathia osteochondroplastica (TPO) is an idiopathic disease involving the cartilage rings of the large airway, characterized by submucosal calcified nodules. Localized tracheobronchial amyloidosis (TBA) is another rare disease with localized amyloid deposits in the tracheobronchial tree. The two diseases rarely coincide, and only a few case reports and series have been reported. A patient with dyspnea was referred to our clinic for suspicion of TBA. Chest computed tomography (CT) scan showed marked thickening of the tracheobronchial wall with calcified endobronchial submucosal nodules. The no...
Source: Respiratory Care - October 3, 2020 Category: Respiratory Medicine Authors: Song JY, Kim BG, Zo S, Park S, Han JH, Kim H Tags: Respir Med Case Rep Source Type: research

Extracorporeal membrane oxygenation in Stenotrophomonas maltophilia pneumonia during acute myeloid leukemia: A case report.
We report a case of a 46-year-old man with Stenotrophomonas maltophilia hemorrhagic pneumonia acquired during consolidation chemotherapy for acute myeloid leukemia in whom VV ECMO lead to a good clinical outcome. The stabilization of his respiratory status achieved with VV ECMO allowed time for trimethoprim-sulfamethoxazole antibiotic therapy to improve the pneumonia. We suggest the background of patients, including comorbidities and general conditions, should be taken into account when considering the clinical indications of ECMO. PMID: 32995263 [PubMed] (Source: Respiratory Care)
Source: Respiratory Care - October 3, 2020 Category: Respiratory Medicine Authors: Saito K, Aokage T, Sato T, Tsukahara K, Tokioka F, Otake T, Irie H, Ueda Y Tags: Respir Med Case Rep Source Type: research

Alkalescent soda beverage caused the disappearance of gefitinib-induced rashes and decreased efficacy in a non-small-cell lung cancer patient treated with gefitinib: A case report.
Abstract Oral anticancer drugs have the advantages of convenient and flexible administration, however, they also face some new problems related to their oral preparation. Herein we describe a case of advanced non-small-cell lung cancer patient treated with gefitinib who had long-term adverse reactions of rashes and diarrhea, and his rashes disappeared after taking alkaline soda, and then reappeared after stopping drinking it. Imaging progress was also observed. To our knowledge, this is the first report on the effect of alkaline food on gefitinib-induced rashes dynamic change. In this case, the rash acted as a sig...
Source: Respiratory Care - October 3, 2020 Category: Respiratory Medicine Authors: Bian S, Tang X, Ye S, Lei W Tags: Respir Med Case Rep Source Type: research

Pulmonary tuberculosis presenting as lung abscess in a 10-month-Old infant.
This report presents the case of a 10-month-old infant who had an unusual presentation of pulmonary tuberculosis with no cough, poor growth or documented temperature>38 C despite extensive right lung involvement with lung abscess formation and pleural effusions. Inflammatory markers were minimally deranged. The diagnosis of pulmonary tuberculosis was confirmed based on positive tuberculosis polymerase chain reaction test. The child made a successful clinical and radiological recovery upon completion of anti-tuberculosis drug regimen for six months. This report brings to light that it is crucial for clinicians to have a ...
Source: Respiratory Care - October 3, 2020 Category: Respiratory Medicine Authors: Thadchanamoorthy V, Dayasiri K Tags: Respir Med Case Rep Source Type: research

COVID-19 pneumonia complicated by bilateral pneumothorax: A case report.
Conclusions: Pneumothorax is a notable complication in cases of severe COVID-19 pneumonia, especially in those who require positive-pressure ventilation. PMID: 32999855 [PubMed] (Source: Respiratory Care)
Source: Respiratory Care - October 3, 2020 Category: Respiratory Medicine Authors: Shirai T, Mitsumura T, Aoyagi K, Okamoto T, Kimura M, Gemma T, Shigematsu T, Takahashi J, Azuma S, Yoshizuka R, Sasaki H, Urushibata N, Ochiai K, Hondo K, Morishita K, Aiboshi J, Otomo Y, Miyazaki Y Tags: Respir Med Case Rep Source Type: research

Clinical deterioration during neutropenia recovery after G-CSF therapy in patient with COVID-19.
Conclusion: We observed a faster neutropenia recovery than previously known after administration of G-CSF in our case and in three similar cases previously reported in literature. This rapid neutropenia recovery and the robust inflammatory response in COVID-19 raise concerns about G-CSF safety in patients with COVID-19. PMID: 32999856 [PubMed] (Source: Respiratory Care)
Source: Respiratory Care - October 3, 2020 Category: Respiratory Medicine Authors: Taha M, Sharma A, Soubani A Tags: Respir Med Case Rep Source Type: research

Ventilator Liberation in the Pediatric ICU.
Abstract Despite the accepted importance of minimizing time on mechanical ventilation, only limited guidance on weaning and extubation is available from the pediatric literature. A significant proportion of patients being evaluated for weaning are actually ready for extubation, suggesting that weaning is often not considered early enough in the course of ventilation. Indications for extubation are often not clear, although a trial of spontaneous breathing on CPAP without pressure support seems an appropriate prerequisite in many cases. Several indexes have been developed to predict weaning and extubation success, ...
Source: Respiratory Care - September 27, 2020 Category: Respiratory Medicine Authors: Newth CJ, Hotz JC, Khemani RG Tags: Respir Care Source Type: research

Inhaled Pulmonary Vasodilators in the Neonatal and Pediatric ICU.
Abstract Inhaled pulmonary vasodilators are a powerful tool in the arsenal of therapies designed to treat pulmonary hypertension in pediatrics. Yet only 1 inhaled vasodilator, inhaled nitric oxide (INO), has been approved by the Food and Drug Administration for use in neonates> 34 weeks gestational age with persistent pulmonary hypertension of the newborn. Off-label use of inhaled vasodilators is common in the neonatal and pediatric population despite a lack of evidence. Growing focus on providing evidence-based therapies combined with the increasing cost of INO has led to the exploration of other inhaled pulmo...
Source: Respiratory Care - September 27, 2020 Category: Respiratory Medicine Authors: Walsh BK Tags: Respir Care Source Type: research

Innovation in Aerosol Drug Delivery During Adult Mechanical Ventilation.
PMID: 32973105 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - September 27, 2020 Category: Respiratory Medicine Authors: Berlinski A Tags: Respir Care Source Type: research

The Basic Problem.
PMID: 32973106 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - September 27, 2020 Category: Respiratory Medicine Authors: Rubin BK Tags: Respir Care Source Type: research

Automated Oxygen Delivery and Conservation: Promises and Pitfalls.
PMID: 32973107 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - September 27, 2020 Category: Respiratory Medicine Authors: Kaczka DW, Herrmann J Tags: Respir Care Source Type: research

Editor's Commentary.
Authors: PMID: 32973108 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - September 27, 2020 Category: Respiratory Medicine Tags: Respir Care Source Type: research

Airway mechanical compression: its role in asthma pathogenesis and progression.
Abstract The lung is a mechanically active organ, but uncontrolled or excessive mechanical forces disrupt normal lung function and can contribute to the development of disease. In asthma, bronchoconstriction leads to airway narrowing and airway wall buckling. A growing body of evidence suggests that pathological mechanical forces induced by airway buckling alone can perpetuate disease processes in asthma. Here, we review the data obtained from a variety of experimental models, including in vitro, ex vivo and in vivo approaches, which have been used to study the impact of mechanical forces in asthma pathogenesis. W...
Source: Respiratory Care - August 14, 2020 Category: Respiratory Medicine Authors: Veerati PC, Mitchel JA, Reid AT, Knight DA, Bartlett NW, Park JA, Grainge CL Tags: Eur Respir Rev Source Type: research

Is ventilated hospital-acquired pneumonia a worse entity than ventilator-associated pneumonia?
CONCLUSION: Nosocomial pneumonia is a multifaced disease with features of pivotal interest in critical care medicine. Due to the worrisome data on mortality of patients with nosocomial pneumonia, further prospective studies focused on this topic are urgently needed. PMID: 32759376 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - August 14, 2020 Category: Respiratory Medicine Authors: Vallecoccia MS, Dominedò C, Cutuli SL, Martin-Loeches I, Torres A, De Pascale G Tags: Eur Respir Rev Source Type: research

Sarcoidosis: Advances in Therapy.
PMID: 32777846 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - August 14, 2020 Category: Respiratory Medicine Authors: Baughman RP, Judson M Tags: Semin Respir Crit Care Med Source Type: research

Overlap Syndromes in Sarcoidosis: Clinical Features and Outcomes.
This article is intended to provide an overview of these presentations and the most commonly associated diseases, with attention to their prevalence, clinical features, and reciprocal impacts on disease outcomes. PMID: 32777847 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - August 14, 2020 Category: Respiratory Medicine Authors: James WE Tags: Semin Respir Crit Care Med Source Type: research

Balancing Altered Calcium Metabolism with Bone Health in Sarcoidosis.
Abstract Abnormal calcium metabolism in sarcoidosis patients can lead to hypercalcemia, hypercalciuria, and kidney stones. Hypercalcemia in sarcoidosis is usually due to increased activity of 1α-hydroxylase in macrophages of pulmonary granulomata, resulting in low levels of 25-hydroxyvitamin D and high levels of calcitriol. Vitamin D supplementation may be dangerous for some sarcoidosis patients and is recommended only for those with decreased 25-hydroxyvitamin D and reduced or normal calcitriol level. Diagnosis, treatment of osteoporosis, and maintenance of bone health are complex issues for sarcoidosis pat...
Source: Respiratory Care - August 14, 2020 Category: Respiratory Medicine Authors: Zhou Y, Lower EE Tags: Semin Respir Crit Care Med Source Type: research