PAP Therapy-Quick Tips for Troubleshooting to Address Problems with Use
Am J Respir Crit Care Med. 2021 Sep 15;204(6):P11-P12. doi: 10.1164/rccm.2046P11.NO ABSTRACTPMID:34543160 | DOI:10.1164/rccm.2046P11 (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 20, 2021 Category: Intensive Care Authors: Helena Schotland Source Type: research

Dynamics of the Upper Respiratory Tract Microbiota and its Association with Mortality in COVID-19
Conclusions:URT microbiota dysbiosis is a remarkable manifestation of COVID-19; its association with mortality suggests it may reflect the interplay between pathogens, symbionts, and the host immune status. Whether URT microbiota could be used as a biomarker for the diagnosis and prognosis of respiratory diseases merits further investigation. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).PMID:34534435 | DOI:10.1164/rccm.202103-0814OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 17, 2021 Category: Intensive Care Authors: Lili Ren Yeming Wang Jiaxin Zhong Xia Li Yan Xiao Jie Li Jing Yang Guohui Fan Li Guo Zijie Shen Lu Kang Leisheng Shi Qiong Li Jizhou Li Lin Di Haibo Li Conghui Wang Ying Wang Xinming Wang Xiaohui Zou Jian Rao Li Zhang Jianbin Wang Yanyi Huang Bin Cao Jian Source Type: research

Follicular Helper-like T Cells in the Lung Highlight a Novel Role of B Cells in Sarcoidosis
CONCLUSIONS: Active T cell / B cell cooperation and local production of potentially pathogenic antibodies in the inflamed lung represents a novel pathomechanism in sarcoidosis and should be considered from both diagnostic and therapeutic perspectives.PMID:34534436 | DOI:10.1164/rccm.202012-4423OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 17, 2021 Category: Intensive Care Authors: Laura Bauer Lisa Jasmin M üller Sarah M Volkers Frederik Heinrich Mir-Farzin Mashreghi Clemens Ruppert Leif E Sander Andreas Hutloff Source Type: research

Longitudinal Dynamics of a Blood Transcriptomic Signature of Tuberculosis
Conclusions Positive RISK11 signature status is often transient, possibly due to intercurrent viral infection, highlighting potentially important challenges for implementation of these biomarkers as new tools for TB control. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:34520313 | DOI:10.1164/rccm.202103-0548OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 14, 2021 Category: Intensive Care Authors: Humphrey Mulenga Munyaradzi Musvosvi Simon C Mendelsohn Adam Penn-Nicholson Stanley Kimbung Mbandi Andrew-Fiore Gartland Mich èle Tameris Simbarashe Mabwe Hadn Africa Nicole Bilek Fazlin Kafaar Shabaana A Khader Balie Carstens Katie Hadley Chris Hikuam M Source Type: research

Longitudinal Dynamics of a Blood Transcriptomic Signature of Tuberculosis
Conclusions Positive RISK11 signature status is often transient, possibly due to intercurrent viral infection, highlighting potentially important challenges for implementation of these biomarkers as new tools for TB control. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:34520313 | DOI:10.1164/rccm.202103-0548OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 14, 2021 Category: Intensive Care Authors: Humphrey Mulenga Munyaradzi Musvosvi Simon C Mendelsohn Adam Penn-Nicholson Stanley Kimbung Mbandi Andrew-Fiore Gartland Mich èle Tameris Simbarashe Mabwe Hadn Africa Nicole Bilek Fazlin Kafaar Shabaana A Khader Balie Carstens Katie Hadley Chris Hikuam M Source Type: research

Longitudinal Dynamics of a Blood Transcriptomic Signature of Tuberculosis
Conclusions Positive RISK11 signature status is often transient, possibly due to intercurrent viral infection, highlighting potentially important challenges for implementation of these biomarkers as new tools for TB control. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:34520313 | DOI:10.1164/rccm.202103-0548OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 14, 2021 Category: Intensive Care Authors: Humphrey Mulenga Munyaradzi Musvosvi Simon C Mendelsohn Adam Penn-Nicholson Stanley Kimbung Mbandi Andrew-Fiore Gartland Mich èle Tameris Simbarashe Mabwe Hadn Africa Nicole Bilek Fazlin Kafaar Shabaana A Khader Balie Carstens Katie Hadley Chris Hikuam M Source Type: research

Longitudinal Dynamics of a Blood Transcriptomic Signature of Tuberculosis
Conclusions Positive RISK11 signature status is often transient, possibly due to intercurrent viral infection, highlighting potentially important challenges for implementation of these biomarkers as new tools for TB control. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:34520313 | DOI:10.1164/rccm.202103-0548OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 14, 2021 Category: Intensive Care Authors: Humphrey Mulenga Munyaradzi Musvosvi Simon C Mendelsohn Adam Penn-Nicholson Stanley Kimbung Mbandi Andrew-Fiore Gartland Mich èle Tameris Simbarashe Mabwe Hadn Africa Nicole Bilek Fazlin Kafaar Shabaana A Khader Balie Carstens Katie Hadley Chris Hikuam M Source Type: research

Longitudinal Dynamics of a Blood Transcriptomic Signature of Tuberculosis
Conclusions Positive RISK11 signature status is often transient, possibly due to intercurrent viral infection, highlighting potentially important challenges for implementation of these biomarkers as new tools for TB control. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:34520313 | DOI:10.1164/rccm.202103-0548OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 14, 2021 Category: Intensive Care Authors: Humphrey Mulenga Munyaradzi Musvosvi Simon C Mendelsohn Adam Penn-Nicholson Stanley Kimbung Mbandi Andrew-Fiore Gartland Mich èle Tameris Simbarashe Mabwe Hadn Africa Nicole Bilek Fazlin Kafaar Shabaana A Khader Balie Carstens Katie Hadley Chris Hikuam M Source Type: research

Modern Lung Magnetic Resonance Imaging to Screen for Pulmonary Complications in Patients with Dyskeratosis Congenita
Am J Respir Crit Care Med. 2021 Sep 13. doi: 10.1164/rccm.202103-0736LE. Online ahead of print.NO ABSTRACTPMID:34516939 | DOI:10.1164/rccm.202103-0736LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 13, 2021 Category: Intensive Care Authors: Laura L Walkup Kasiani C Myers Matthew M Willmering Parinda A Mehta Adam S Nelson Robert J Fleck Jason C Woods Stella M Davies Christopher T Towe Source Type: research

Ensuring Access to Albuterol in Schools: From Policy to Implementation. An Official ATS/AANMA/ALA/NASN Policy Statement
Conclusions: Stock albuterol in schools is a safe, practical, and potentially life-saving option for children with asthma, whether asthma is diagnosed or undiagnosed, who lack access to their personal quick-relief medication. Legislation is imperative for aiding in the adoption and implementation of school stock albuterol policies, and key policy inclusions can lay the groundwork for success. Future work should focus on passing legislation in all states, implementing policy in schools, and evaluating the impact of such programs on academic and health outcomes.PMID:34499024 | DOI:10.1164/rccm.202106-1550ST (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 9, 2021 Category: Intensive Care Authors: Anna Volerman Ashley A Lowe Andrea A Pappalardo Charmayne M C Anderson Kathryn V Blake Tyra Bryant-Stephens Thomas Carr Heather Carter Lisa Cicutto Joe K Gerald Tina Miller Nuala S Moore Hanna Phan S Christy Sadreameli Andrea Tanner Tonya A Winders Lynn B Source Type: research

Inhaled Marijuana and the Lungs
Am J Respir Crit Care Med. 2021 Sep 1;204(5):P9-P10. doi: 10.1164/rccm.2044P9.NO ABSTRACTPMID:34499025 | DOI:10.1164/rccm.2044P9 (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 9, 2021 Category: Intensive Care Authors: Sarah Neff Matthew G Drake Christopher G Slatore Ellen Burnham Source Type: research

Simulation of Ventilator Allocation in Critically Ill Patients with COVID-19
Am J Respir Crit Care Med. 2021 Sep 9. doi: 10.1164/rccm.202106-1453LE. Online ahead of print.NO ABSTRACTPMID:34499587 | DOI:10.1164/rccm.202106-1453LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 9, 2021 Category: Intensive Care Authors: Sivasubramanium V Bhavani Yuan Luo William D Miller Lazaro N Sanchez-Pinto Xuan Han Chengsheng Mao Burhaneddin Sandikci Monica E Peek Craig M Coopersmith Kelly N Michelson William F Parker Source Type: research

Reduced Exercise Capacity in Adults Born Very Low Birth Weight: A Population-Based Cohort Study
Am J Respir Crit Care Med. 2021 Sep 9. doi: 10.1164/rccm.202103-0755OC. Online ahead of print.ABSTRACTRATIONALE: Population-based data regarding the consequences of very low birth weight (VLBW) and bronchopulmonary dysplasia (BPD) on adult exercise capacity is limited.OBJECTIVES: To compare exercise capacity in a national VLBW cohort with term-born controls and explore factors contributing to the differences.METHODS: At 26-30 years of age, 228 VLBW survivors and 100 controls underwent lung function tests, cardiopulmonary exercise testing and assessment of resting cardiac structure/function using echocardiography. Data on s...
Source: Am J Respir Crit Car... - September 9, 2021 Category: Intensive Care Authors: Jun Yang Michael J Epton Sarah L Harris John Horwood Rachel A Kingsford Richard Troughton Charlotte Greer Brian A Darlow Source Type: research

Ensuring Access to Albuterol in Schools: From Policy to Implementation. An Official ATS/AANMA/ALA/NASN Policy Statement
Conclusions: Stock albuterol in schools is a safe, practical, and potentially life-saving option for children with asthma, whether asthma is diagnosed or undiagnosed, who lack access to their personal quick-relief medication. Legislation is imperative for aiding in the adoption and implementation of school stock albuterol policies, and key policy inclusions can lay the groundwork for success. Future work should focus on passing legislation in all states, implementing policy in schools, and evaluating the impact of such programs on academic and health outcomes.PMID:34499024 | DOI:10.1164/rccm.202106-1550ST (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 9, 2021 Category: Intensive Care Authors: Anna Volerman Ashley A Lowe Andrea A Pappalardo Charmayne M C Anderson Kathryn V Blake Tyra Bryant-Stephens Thomas Carr Heather Carter Lisa Cicutto Joe K Gerald Tina Miller Nuala S Moore Hanna Phan S Christy Sadreameli Andrea Tanner Tonya A Winders Lynn B Source Type: research

Inhaled Marijuana and the Lungs
Am J Respir Crit Care Med. 2021 Sep 1;204(5):P9-P10. doi: 10.1164/rccm.2044P9.NO ABSTRACTPMID:34499025 | DOI:10.1164/rccm.2044P9 (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 9, 2021 Category: Intensive Care Authors: Sarah Neff Matthew G Drake Christopher G Slatore Ellen Burnham Source Type: research

Simulation of Ventilator Allocation in Critically Ill Patients with COVID-19
Am J Respir Crit Care Med. 2021 Sep 9. doi: 10.1164/rccm.202106-1453LE. Online ahead of print.NO ABSTRACTPMID:34499587 | DOI:10.1164/rccm.202106-1453LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 9, 2021 Category: Intensive Care Authors: Sivasubramanium V Bhavani Yuan Luo William D Miller Lazaro N Sanchez-Pinto Xuan Han Chengsheng Mao Burhaneddin Sandikci Monica E Peek Craig M Coopersmith Kelly N Michelson William F Parker Source Type: research

Reduced Exercise Capacity in Adults Born Very Low Birth Weight: A Population-Based Cohort Study
Am J Respir Crit Care Med. 2021 Sep 9. doi: 10.1164/rccm.202103-0755OC. Online ahead of print.ABSTRACTRATIONALE: Population-based data regarding the consequences of very low birth weight (VLBW) and bronchopulmonary dysplasia (BPD) on adult exercise capacity is limited.OBJECTIVES: To compare exercise capacity in a national VLBW cohort with term-born controls and explore factors contributing to the differences.METHODS: At 26-30 years of age, 228 VLBW survivors and 100 controls underwent lung function tests, cardiopulmonary exercise testing and assessment of resting cardiac structure/function using echocardiography. Data on s...
Source: Am J Respir Crit Car... - September 9, 2021 Category: Intensive Care Authors: Jun Yang Michael J Epton Sarah L Harris John Horwood Rachel A Kingsford Richard Troughton Charlotte Greer Brian A Darlow Source Type: research

Ensuring Access to Albuterol in Schools: From Policy to Implementation. An Official ATS/AANMA/ALA/NASN Policy Statement
Conclusions: Stock albuterol in schools is a safe, practical, and potentially life-saving option for children with asthma, whether asthma is diagnosed or undiagnosed, who lack access to their personal quick-relief medication. Legislation is imperative for aiding in the adoption and implementation of school stock albuterol policies, and key policy inclusions can lay the groundwork for success. Future work should focus on passing legislation in all states, implementing policy in schools, and evaluating the impact of such programs on academic and health outcomes.PMID:34499024 | DOI:10.1164/rccm.202106-1550ST (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 9, 2021 Category: Intensive Care Authors: Anna Volerman Ashley A Lowe Andrea A Pappalardo Charmayne M C Anderson Kathryn V Blake Tyra Bryant-Stephens Thomas Carr Heather Carter Lisa Cicutto Joe K Gerald Tina Miller Nuala S Moore Hanna Phan S Christy Sadreameli Andrea Tanner Tonya A Winders Lynn B Source Type: research

Inhaled Marijuana and the Lungs
Am J Respir Crit Care Med. 2021 Sep 1;204(5):P9-P10. doi: 10.1164/rccm.2044P9.NO ABSTRACTPMID:34499025 | DOI:10.1164/rccm.2044P9 (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 9, 2021 Category: Intensive Care Authors: Sarah Neff Matthew G Drake Christopher G Slatore Ellen Burnham Source Type: research

Simulation of Ventilator Allocation in Critically Ill Patients with COVID-19
Am J Respir Crit Care Med. 2021 Sep 9. doi: 10.1164/rccm.202106-1453LE. Online ahead of print.NO ABSTRACTPMID:34499587 | DOI:10.1164/rccm.202106-1453LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 9, 2021 Category: Intensive Care Authors: Sivasubramanium V Bhavani Yuan Luo William D Miller Lazaro N Sanchez-Pinto Xuan Han Chengsheng Mao Burhaneddin Sandikci Monica E Peek Craig M Coopersmith Kelly N Michelson William F Parker Source Type: research

Reduced Exercise Capacity in Adults Born Very Low Birth Weight: A Population-Based Cohort Study
Am J Respir Crit Care Med. 2021 Sep 9. doi: 10.1164/rccm.202103-0755OC. Online ahead of print.ABSTRACTRATIONALE: Population-based data regarding the consequences of very low birth weight (VLBW) and bronchopulmonary dysplasia (BPD) on adult exercise capacity is limited.OBJECTIVES: To compare exercise capacity in a national VLBW cohort with term-born controls and explore factors contributing to the differences.METHODS: At 26-30 years of age, 228 VLBW survivors and 100 controls underwent lung function tests, cardiopulmonary exercise testing and assessment of resting cardiac structure/function using echocardiography. Data on s...
Source: Am J Respir Crit Car... - September 9, 2021 Category: Intensive Care Authors: Jun Yang Michael J Epton Sarah L Harris John Horwood Rachel A Kingsford Richard Troughton Charlotte Greer Brian A Darlow Source Type: research

Ensuring Access to Albuterol in Schools: From Policy to Implementation. An Official ATS/AANMA/ALA/NASN Policy Statement
Conclusions: Stock albuterol in schools is a safe, practical, and potentially life-saving option for children with asthma, whether asthma is diagnosed or undiagnosed, who lack access to their personal quick-relief medication. Legislation is imperative for aiding in the adoption and implementation of school stock albuterol policies, and key policy inclusions can lay the groundwork for success. Future work should focus on passing legislation in all states, implementing policy in schools, and evaluating the impact of such programs on academic and health outcomes.PMID:34499024 | DOI:10.1164/rccm.202106-1550ST (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 9, 2021 Category: Intensive Care Authors: Anna Volerman Ashley A Lowe Andrea A Pappalardo Charmayne M C Anderson Kathryn V Blake Tyra Bryant-Stephens Thomas Carr Heather Carter Lisa Cicutto Joe K Gerald Tina Miller Nuala S Moore Hanna Phan S Christy Sadreameli Andrea Tanner Tonya A Winders Lynn B Source Type: research

Inhaled Marijuana and the Lungs
Am J Respir Crit Care Med. 2021 Sep 1;204(5):P9-P10. doi: 10.1164/rccm.2044P9.NO ABSTRACTPMID:34499025 | DOI:10.1164/rccm.2044P9 (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 9, 2021 Category: Intensive Care Authors: Sarah Neff Matthew G Drake Christopher G Slatore Ellen Burnham Source Type: research

Simulation of Ventilator Allocation in Critically Ill Patients with COVID-19
Am J Respir Crit Care Med. 2021 Sep 9. doi: 10.1164/rccm.202106-1453LE. Online ahead of print.NO ABSTRACTPMID:34499587 | DOI:10.1164/rccm.202106-1453LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 9, 2021 Category: Intensive Care Authors: Sivasubramanium V Bhavani Yuan Luo William D Miller Lazaro N Sanchez-Pinto Xuan Han Chengsheng Mao Burhaneddin Sandikci Monica E Peek Craig M Coopersmith Kelly N Michelson William F Parker Source Type: research

Reduced Exercise Capacity in Adults Born Very Low Birth Weight: A Population-Based Cohort Study
Am J Respir Crit Care Med. 2021 Sep 9. doi: 10.1164/rccm.202103-0755OC. Online ahead of print.ABSTRACTRATIONALE: Population-based data regarding the consequences of very low birth weight (VLBW) and bronchopulmonary dysplasia (BPD) on adult exercise capacity is limited.OBJECTIVES: To compare exercise capacity in a national VLBW cohort with term-born controls and explore factors contributing to the differences.METHODS: At 26-30 years of age, 228 VLBW survivors and 100 controls underwent lung function tests, cardiopulmonary exercise testing and assessment of resting cardiac structure/function using echocardiography. Data on s...
Source: Am J Respir Crit Car... - September 9, 2021 Category: Intensive Care Authors: Jun Yang Michael J Epton Sarah L Harris John Horwood Rachel A Kingsford Richard Troughton Charlotte Greer Brian A Darlow Source Type: research

Reply to: Olfactory-nasal Nitric-oxide Link in COVID-19: A Marker of Neurogenesis or Risk Factor for Chronic Rhinosinusitis?
Am J Respir Crit Care Med. 2021 Sep 7. doi: 10.1164/rccm.202108-1827LE. Online ahead of print.NO ABSTRACTPMID:34491870 | DOI:10.1164/rccm.202108-1827LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 7, 2021 Category: Intensive Care Authors: Anh Tuan Dinh-Xuan Th ông Hua-Huy all authors of “Persistent Nasal Inflammation 5 Months after Acute Anosmia in Patients with COVID-19” Source Type: research

Olfactory-nasal Nitric-oxide Link in COVID-19: A Marker of Neurogenesis or Risk Factor for Chronic Rhinosinusitis?
Am J Respir Crit Care Med. 2021 Sep 7. doi: 10.1164/rccm.202107-1697LE. Online ahead of print.NO ABSTRACTPMID:34491873 | DOI:10.1164/rccm.202107-1697LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 7, 2021 Category: Intensive Care Authors: Amit Jain Source Type: research

Everolimus-Eluting Stent-Induced Pneumonitis
Am J Respir Crit Care Med. 2021 Sep 7. doi: 10.1164/rccm.202103-0565IM. Online ahead of print.NO ABSTRACTPMID:34491881 | DOI:10.1164/rccm.202103-0565IM (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 7, 2021 Category: Intensive Care Authors: Haruki Kobayashi Source Type: research

Transvenous Diaphragm Neurostimulation Mitigates Ventilation-associated Brain Injury
Am J Respir Crit Care Med. 2021 Sep 7. doi: 10.1164/rccm.202101-0076OC. Online ahead of print.ABSTRACTRATIONALE: Mechanical ventilation (MV) is associated with hippocampal apoptosis and inflammation, and it is important to study strategies to mitigate them.OBJECTIVES: Explore whether temporary transvenous diaphragm neurostimulation (TTDN) in association with MV mitigates hippocampal apoptosis and inflammation after 50 hours of MV.METHODS: Normal-lung porcine study comparing apoptotic index, inflammatory markers, and neurological-damage serum markers between never-ventilated subjects, subjects undergoing 50 hours of MV plus...
Source: Am J Respir Crit Car... - September 7, 2021 Category: Intensive Care Authors: Thiago G Bassi Elizabeth C Rohrs Karl C Fernandez Marlena Ornoswska Michelle Nicholas Matt Gani Doug Evans Steven C Reynolds Source Type: research

Reply to: Olfactory-nasal Nitric-oxide Link in COVID-19: A Marker of Neurogenesis or Risk Factor for Chronic Rhinosinusitis?
Am J Respir Crit Care Med. 2021 Sep 7. doi: 10.1164/rccm.202108-1827LE. Online ahead of print.NO ABSTRACTPMID:34491870 | DOI:10.1164/rccm.202108-1827LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 7, 2021 Category: Intensive Care Authors: Anh Tuan Dinh-Xuan Th ông Hua-Huy all authors of “Persistent Nasal Inflammation 5 Months after Acute Anosmia in Patients with COVID-19” Source Type: research

Olfactory-nasal Nitric-oxide Link in COVID-19: A Marker of Neurogenesis or Risk Factor for Chronic Rhinosinusitis?
Am J Respir Crit Care Med. 2021 Sep 7. doi: 10.1164/rccm.202107-1697LE. Online ahead of print.NO ABSTRACTPMID:34491873 | DOI:10.1164/rccm.202107-1697LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 7, 2021 Category: Intensive Care Authors: Amit Jain Source Type: research

Everolimus-Eluting Stent-Induced Pneumonitis
Am J Respir Crit Care Med. 2021 Sep 7. doi: 10.1164/rccm.202103-0565IM. Online ahead of print.NO ABSTRACTPMID:34491881 | DOI:10.1164/rccm.202103-0565IM (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 7, 2021 Category: Intensive Care Authors: Haruki Kobayashi Source Type: research

Transvenous Diaphragm Neurostimulation Mitigates Ventilation-associated Brain Injury
Am J Respir Crit Care Med. 2021 Sep 7. doi: 10.1164/rccm.202101-0076OC. Online ahead of print.ABSTRACTRATIONALE: Mechanical ventilation (MV) is associated with hippocampal apoptosis and inflammation, and it is important to study strategies to mitigate them.OBJECTIVES: Explore whether temporary transvenous diaphragm neurostimulation (TTDN) in association with MV mitigates hippocampal apoptosis and inflammation after 50 hours of MV.METHODS: Normal-lung porcine study comparing apoptotic index, inflammatory markers, and neurological-damage serum markers between never-ventilated subjects, subjects undergoing 50 hours of MV plus...
Source: Am J Respir Crit Car... - September 7, 2021 Category: Intensive Care Authors: Thiago G Bassi Elizabeth C Rohrs Karl C Fernandez Marlena Ornoswska Michelle Nicholas Matt Gani Doug Evans Steven C Reynolds Source Type: research

Can N3 Period Duration Serve as a Predictor of Cognitive Dysfunction?
Am J Respir Crit Care Med. 2021 Sep 3. doi: 10.1164/rccm.202105-1231LE. Online ahead of print.NO ABSTRACTPMID:34478349 | DOI:10.1164/rccm.202105-1231LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 3, 2021 Category: Intensive Care Authors: Zhenzhen Zheng Riken Chen Cheng Hong Jianmin Lu Chunying Zhuang Haimin Liu Yue Zhong Nuofu Zhang Source Type: research

Reply to: Can N3 Period Duration Serve as a Predictor of Cognitive Dysfunction?
Am J Respir Crit Care Med. 2021 Sep 3. doi: 10.1164/rccm.202106-1414LE. Online ahead of print.NO ABSTRACTPMID:34478350 | DOI:10.1164/rccm.202106-1414LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 3, 2021 Category: Intensive Care Authors: Ina E Djonlagic Meng Guo Moroke Igue Divya Kishore Robert Stickgold Atul Malhotra Source Type: research

Obstructive Apneas in a Mouse Model of Congenital Central Hypoventilation Syndrome
Am J Respir Crit Care Med. 2021 Sep 3. doi: 10.1164/rccm.202104-0887OC. Online ahead of print.ABSTRACTRATIONALE: Congenital Central Hypoventilation Syndrome (CCHS) is characterized by life-threatening sleep hypoventilation and is caused by PHOX2B gene mutations, most frequently the PHOX2B27Ala/+ mutation, with patients requiring lifelong ventilatory support. It is unclear whether obstructive apneas are part of the syndrome.OBJECTIVES: To determine if Phox2b27Ala/+ mice, which present the main symptoms of CCHS and die within hours after birth, also express obstructive apneas, and to investigate potential underlying mechanis...
Source: Am J Respir Crit Car... - September 3, 2021 Category: Intensive Care Authors: Am élia Madani Gabriel Pitollat El éonore Sizun Laura Cardoit Maud Ringot Thomas Bourgeois Nelina Ramanantsoa Christophe Delclaux St éphane Dauger Marie-Pia d'Ortho Muriel Thoby-Brisson Jorge Gallego Boris Matrot Source Type: research

Epigenomic Landscape, A Cornerstone of Macrophage Phenotype Regulation in the Fibrotic Lung
Am J Respir Crit Care Med. 2021 Sep 3. doi: 10.1164/rccm.202107-1760ED. Online ahead of print.NO ABSTRACTPMID:34478358 | DOI:10.1164/rccm.202107-1760ED (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 3, 2021 Category: Intensive Care Authors: Megan N Ballinger Ana L Mora Source Type: research

Dynamic Metabolic Risk Profiling of World Trade Center-Lung Disease: A Longitudinal Cohort Study
Am J Respir Crit Care Med. 2021 Sep 2. doi: 10.1164/rccm.202006-2617OC. Online ahead of print.ABSTRACTRATIONALE. Metabolic Syndrome (MetSyn) increases the risk of World Trade Center-Lung Injury (WTC-LI). However, the temporal relationship of MetSyn, exposure intensity, and lung dysfunction is not well understood. We modeled the association of longitudinal MetSyn characteristics with WTC-lung disease to define modifiable risk. METHODS. Consented firefighters (N=5,738) were active-duty on 9/11/01 (9/11). WTC-LI (N=1,475; FEV1%predicted
Source: Am J Respir Crit Car... - September 2, 2021 Category: Intensive Care Authors: Sophia Kwon Myeonggyun Lee George Crowley Theresa Schwartz Rachel Zeig-Owens David J Prezant Mengling Liu Anna Nolan Source Type: research

Reply to: Pulmonary Hypertension: A Predictor of Lung Cancer Prognosis?
Am J Respir Crit Care Med. 2021 Sep 2. doi: 10.1164/rccm.202106-1411LE. Online ahead of print.NO ABSTRACTPMID:34473933 | DOI:10.1164/rccm.202106-1411LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 2, 2021 Category: Intensive Care Authors: Bastian Eul Michael Cekay Soni Savai Pullamsetti Khodr Tello Jochen Wilhelm Stefan Gattenl öhner Ulf Sibelius Friedrich Grimminger Werner Seeger Rajkumar Savai Source Type: research

The Renin-Angiotensin-Aldosterone System in COVID-related and non-COVID-related ARDS: Not So Different After All?
Am J Respir Crit Care Med. 2021 Sep 2. doi: 10.1164/rccm.202108-1904ED. Online ahead of print.NO ABSTRACTPMID:34473935 | DOI:10.1164/rccm.202108-1904ED (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 2, 2021 Category: Intensive Care Authors: Sean P Collins Mark C Chappell D Clark Files Source Type: research

Pulmonary Hypertension: A Predictor of Lung Cancer Prognosis?
Am J Respir Crit Care Med. 2021 Sep 2. doi: 10.1164/rccm.202105-1256LE. Online ahead of print.NO ABSTRACTPMID:34473936 | DOI:10.1164/rccm.202105-1256LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 2, 2021 Category: Intensive Care Authors: Zhenzhen Zheng Riken Chen Nuofu Zhang Chunying Zhuang Jianmin Lu Yue Zhong Haimin Liu Cheng Hong Source Type: research

Endobronchial Optical Coherence Tomography for the Diagnosis of Fibrotic ILD: A Light at the End of the Tunnel?
Am J Respir Crit Care Med. 2021 Sep 2. doi: 10.1164/rccm.202108-1899ED. Online ahead of print.NO ABSTRACTPMID:34473937 | DOI:10.1164/rccm.202108-1899ED (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 2, 2021 Category: Intensive Care Authors: Daniel-Costin Marinescu Christopher J Ryerson Source Type: research

Multiomics Analysis Reveals Distinct Immunogenomic Features of Lung Cancer with Ground-Glass Opacity
Conclusions Compared to lung cancers presenting with solid lung nodules, GGO-associated lung cancers are characterized by less active metabolism and immune microenvironment that may be the mechanisms underlying their indolent clinical course.PMID:34473939 | DOI:10.1164/rccm.202101-0119OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 2, 2021 Category: Intensive Care Authors: Kezhong Chen Jing Bai Alexandre Reuben Heng Zhao Guannan Kang Chunliu Zhang Qingyi Qi Yaping Xu Shawna Hubert Lianpeng Chang Yanfang Guan Lin Feng Kai Zhang Kaitai Zhang Xin Yi Xuefeng Xia Shujun Cheng Fan Yang Jianjun Zhang Jun Wang Source Type: research

Pulmonary Innate Lymphoid Cell Responses during Rhinovirus-induced Asthma Exacerbations < em > In Vivo < /em > : A Clinical Trial
Am J Respir Crit Care Med. 2021 Sep 1. doi: 10.1164/rccm.202010-3754OC. Online ahead of print.ABSTRACTRationale Type 2 innate lymphoid cells (ILC2s) are significant sources of type 2 cytokines, which are implicated in the pathogenesis of asthma and asthma exacerbations. The role of ILC2s in virus-induced asthma exacerbations is not well-characterized. Objectives To characterize pulmonary ILC responses following experimental rhinovirus challenge in patients with moderate asthma and healthy subjects. Methods Patients with moderate asthma and healthy subjects were inoculated with rhinovirus-16, and underwent bronchoscopy at b...
Source: Am J Respir Crit Car... - September 1, 2021 Category: Intensive Care Authors: Jaideep Dhariwal Aoife Cameron Ernie Wong Malte Paulsen Belen Trujillo-Torralbo Ajerico Del Rosario Eteri Bakhsoliani Tatiana Kebadze Mark Almond Hugo Farne Leila Gogsadze Julia Aniscenko Batika Rana Trevor T Hansel David J Jackson Onn Min Kon Michael R E Source Type: research

Cystic Fibrosis-related Diabetes is Associated with Worse Lung Function Trajectory Despite Ivacaftor Use
Am J Respir Crit Care Med. 2021 Sep 1. doi: 10.1164/rccm.202104-1060LE. Online ahead of print.NO ABSTRACTPMID:34469275 | DOI:10.1164/rccm.202104-1060LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 1, 2021 Category: Intensive Care Authors: Charles D Bengtson Jianghua He Michael D Kim Matthias A Salathe Source Type: research

Poor Adherence to Continuous Positive Airway Pressure Hugely Improved During COVID-19 Lockdown in France
Am J Respir Crit Care Med. 2021 Sep 1. doi: 10.1164/rccm.202103-0803LE. Online ahead of print.NO ABSTRACTPMID:34469697 | DOI:10.1164/rccm.202103-0803LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 1, 2021 Category: Intensive Care Authors: Jean-Louis P épin Najeh Daabek S ébastien Bailly Renaud Tamisier David Attias Atul Pathak Source Type: research

A Randomized Trial of Antimicrobial Duration for Cystic Fibrosis Pulmonary Exacerbation Treatment
CONCLUSIONS: Among CF adults with early treatment improvement during exacerbation, ppFEV1 after 10-days of intravenous antimicrobials is not inferior to 14-days. For those with less improvement after one week, 21-days is not superior to 14-days. Clinical trial registration available at www.clinicaltrials.gov, ID: NCT02781610.PMID:34469706 | DOI:10.1164/rccm.202102-0461OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 1, 2021 Category: Intensive Care Authors: Christopher H Goss Sonya L Heltshe Natalie E West Michelle Skalland Don B Sanders Raksha Jain Tara L Barto Barbra Fogarty Bruce C Marshall Donald R VanDevanter Patrick A Flume STOP2 Investigators Source Type: research

Integrated Biomarkers for the Management of Indeterminate Pulmonary Nodules
Am J Respir Crit Care Med. 2021 Aug 31. doi: 10.1164/rccm.202012-4438OC. Online ahead of print.ABSTRACTRationale- Patients with indeterminate pulmonary nodules (IPNs) at risk of cancer undergo high rates of invasive, costly, and morbid procedures. Objectives: To train and externally validate a risk prediction model which combined clinical, blood, and imaging biomarkers to improve the noninvasive management of IPNs. Methods - In this prospectively collected, retrospective blinded evaluation (PRoBE) study, probability of cancer was calculated for 456 patient nodules using the Mayo Clinic Model and patients were categorized i...
Source: Am J Respir Crit Car... - August 31, 2021 Category: Intensive Care Authors: Michael N Kammer Dhairya A Lakhani Aneri B Balar Sanja L Antic Amanda K Kussrow Rebekah L Webster Shayan Mahapatra Udaykamal Barad Chirayu Shah Thomas Atwater Brenda Diergaarde Jun Qian Alexander Kaizer Melissa New Erin Hirsch William J Feser Jolene Stron Source Type: research

Effect of Esophageal Pressure-Guided Positive End-Expiratory Pressure on Survival from Acute Respiratory Distress Syndrome: A Risk-Based and Mechanistic Reanalysis of the EPVent-2 Trial
CONCLUSIONS: The effect on survival of PES-guided PEEP, compared to empirical high PEEP, differed by multiorgan dysfunction severity. Independent of multiorgan dysfunction, PEEP titrated to end-expiratory transpulmonary pressure closer to 0 cmH2O was associated with greater survival than more positive or negative values. These findings warrant prospective testing in a future trial.PMID:34464237 | DOI:10.1164/rccm.202009-3539OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - August 31, 2021 Category: Intensive Care Authors: Todd Sarge Elias Baedorf-Kassis Valerie Banner-Goodspeed Victor Novack Stephen H Loring Michelle N Gong Deborah Cook Daniel Talmor Jeremy R Beitler EPVent-2 Study Group Source Type: research

Effects of Inhaled Corticosteroid/long-acting beta-2 Agonist Combination on the Airway Microbiome of Patients with COPD: A Randomized Controlled Trial (DISARM)
CONCLUSIONS: Fluticasone-based ICS/LABA therapy modifies the airway microbiome in COPD, leading to a relative reduction in alpha diversity and a greater number of bacterial taxa changes. These data may have implications in patients who develop pneumonia on ICS. Clinical trial registration available at www.clinicaltrials.gov, ID:NCT02833480.PMID:34464242 | DOI:10.1164/rccm.202102-0289OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - August 31, 2021 Category: Intensive Care Authors: Fernando Sergio Leitao Filho Hiroto Takiguchi Kentaro Akata Seung Won Ra Ji-Yong Moon Hyun Kuk Kim Yuji Cho Kei Yamasaki Stephen Milne Julia Yang Cheng Wei Tony Yang Xuan Li Corey Nislow Stephan F van Eeden Tawimas Shaipanich Stephen Lam Janice M Leung Do Source Type: research