Seroprevalence of SARS-CoV-2 Neutralizing Antibodies among Blood Donors in Ho Chi Minh City, Vietnam, August-November 2020
Am J Trop Med Hyg. 2022 Jan 26:tpmd210259. doi: 10.4269/ajtmh.21-0259. Online ahead of print.ABSTRACTRelatively little is known about the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG antibodies and COVID-19-related behaviors in the general population in Vietnam, where the first case of COVID-19 was detected on January 22, 2020. We surveyed a group of 885 blood donors at community blood donation sessions in Ho Chi Minh City from August 27 to November 7, 2020. Blood was collected to test for SARS-CoV-2 IgG antibodies using the plaque reduction neutralization test. We adjusted the seropre...
Source: The American Journal of Tropical Medicine and Hygiene - January 26, 2022 Category: Tropical Medicine Authors: Hanh Hong Ho Nguyen Quan Hoang Nguyen Dung Thi Thuy Truong Manh Huy Dao Tu Ngoc Le Hieu Trung Nguyen Anh Hoang Nguyen Thinh Viet Nguyen Dao Thi Nhu Hoang Loan Kim Hoang Tham Thi Tran Thang Minh Cao Quang Chan Luong Lan Trong Phan Loan Thi Kim Huynh Thuong Source Type: research

Pediatric Medicaid Visits for Soil-Transmitted Helminth Infections in the Black Belt Region-Alabama, 2010-2018
We describe pediatric Medicaid STH visits in Alabama and compare STH visit rates in Black Belt counties with those of non-Black Belt counties. Alabama Medicaid visit claims among children aged 0-18 years who received an STH diagnosis during January 2010-December 2018 were examined. STH-related pediatric visits were uncommon, but several counties with higher STH rates were identified. Visit rates did not differ meaningfully when comparing Black Belt with non-Black Belt region counties (rate ratio: 1.10; 95% CI: 0.73-1.64). Additional studies examining STH prevalence among children living in communities at risk for STH in Al...
Source: The American Journal of Tropical Medicine and Hygiene - January 24, 2022 Category: Tropical Medicine Authors: Guillermo V Sanchez Anna J Blackstock Sherri L Davidson Source Type: research

Examining the Intersection between Gender, Community Health Workers, and Vector Control Policies: A Text Mining Literature Review
Am J Trop Med Hyg. 2022 Jan 24:tpmd210619. doi: 10.4269/ajtmh.21-0619. Online ahead of print.ABSTRACTGender intersects with healthcare systems; this is equally true for arboviral vector control efforts. However, there is as yet no comprehensive analysis as to how vector control is gendered. Hence, our objective is to provide the first thematic scoping and spatial distribution of the literature on gender, community health workers, and vector control. The authors use a systematic review approach to collect the academic literature on gender, community health workers, and vector control in Web of Science, Scopus, and PubMed (7...
Source: The American Journal of Tropical Medicine and Hygiene - January 24, 2022 Category: Tropical Medicine Authors: Ana De Menezes Ana Carolina Nunes Denise Nacif Pimenta Gabriela Lotta Theresia Nkya Morgana Martins Krieger Brunah Schall Clare Wenham Source Type: research

Ulcerative Lesion Caused by Inoculation of Leishmanin
Am J Trop Med Hyg. 2022 Jan 24:tpmd201248. doi: 10.4269/ajtmh.20-1248. Online ahead of print.NO ABSTRACTPMID:35073507 | DOI:10.4269/ajtmh.20-1248 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - January 24, 2022 Category: Tropical Medicine Authors: Jes ús Rojas-Jaimes Source Type: research

Case Report: COVID-19 Infection and Cervical Artery Dissection
Am J Trop Med Hyg. 2022 Jan 24:tpmd210999. doi: 10.4269/ajtmh.21-0999. Online ahead of print.ABSTRACTA 45-year-old woman presented 3 days after symptom resolution from a COVID-19 infection with a left vertebral artery dissection with no known preceding trauma or underlying disposition. She subsequently suffered a left lateral medullary stroke 15 hours after her initial presentation. Cervical artery dissections (CeAD) can occur in the absence of trauma, and in some cases, infection may be a contributing factor. COVID-19 infection can cause an endotheliopathy and inflammatory response, which may contribute to intimal vessel ...
Source: The American Journal of Tropical Medicine and Hygiene - January 24, 2022 Category: Tropical Medicine Authors: Kaylynn Purdy Rebecca Long Glen Jickling Source Type: research

Effects of Temephos (Abate ®), Spinosad (Natular®), and Diflubenzuron on the Survival of Cyclopoid Copepods
Am J Trop Med Hyg. 2022 Jan 24:tpmd210818. doi: 10.4269/ajtmh.21-0818. Online ahead of print.ABSTRACTDracunculus medinensis, also known as the African Guinea worm, is the causative agent of dracunculiasis and the focus of the global Guinea Worm Eradication Program (GWEP). Transmission of D. medinensis to humans occurs primarily by drinking water containing cyclopoid copepods infected with third-stage D. medinensis larvae. A common intervention to interrupt transmission and decrease the number of copepods in infected water bodies is the application of the organophosphate larvicide Abate® (temephos). However, the use of ...
Source: The American Journal of Tropical Medicine and Hygiene - January 24, 2022 Category: Tropical Medicine Authors: Ryan Grunert Erin Box Kayla Garrett Michael Yabsley Christopher Cleveland Source Type: research

Lymphocutaneous Sporotrichosis
Am J Trop Med Hyg. 2022 Jan 24:tpmd211212. doi: 10.4269/ajtmh.21-1212. Online ahead of print.NO ABSTRACTPMID:35073510 | DOI:10.4269/ajtmh.21-1212 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - January 24, 2022 Category: Tropical Medicine Authors: Alvaro Schwalb Paloma M Carcamo Carlos Seas Source Type: research

Risk Factors of Septic Metastatic Infection among Patients with Klebsiella pneumoniae Liver Abscess in Singapore: A Case-Control Study
This study aimed to determine the risk factors associated with metastatic infection among patients with KPLA in Singapore. A retrospective case-control analysis among adult patients admitted to the National University Hospital with KPLA between 2013 and 2017 was conducted. Univariate and multivariate regression analysis was conducted. Of the 116 KPLA patients, 38.8% had pulmonary metastatic infection. Length of hospital stay (P = 0.001) and intensive care unit admissions (P = 0.044) were significantly longer and greater, respectively, among the patients with metastatic infection. Sepsis-induced hypotension (adjusted odds r...
Source: The American Journal of Tropical Medicine and Hygiene - January 24, 2022 Category: Tropical Medicine Authors: Shilpa Mukherjee Sophia Archuleta Junxiong Pang Source Type: research

Evidence of Coinfections between SARS-CoV-2 and Select Arboviruses in Guerrero, Mexico, 2020-2021
Am J Trop Med Hyg. 2022 Jan 24:tpmd211216. doi: 10.4269/ajtmh.21-1216. Online ahead of print.ABSTRACTWe provide evidence of concurrent and close sequential infections between SARS-CoV-2 and select arboviruses-namely, chikungunya virus (CHIKV); dengue viruses 1, 2, and 3 (DENV1-3), and Zika virus (ZIKV)-in patients in Guerrero, southwest Mexico, in 2020-2021. The study population consisted of 176 febrile patients with laboratory evidence of SARS-CoV-2 infection. Sera from all patients were serologically and antigenically tested for seven arboviruses known to occur in Guerrero. Eighteen patients contained CHIKV IgM, six of w...
Source: The American Journal of Tropical Medicine and Hygiene - January 24, 2022 Category: Tropical Medicine Authors: Daniel Nunez-Avellaneda Fabian R Villag ómez Julio C Villegas-Pineda Jacqueline Barrios-Palacios Ma Isabel Salazar Carlos Machain-Williams Bradley J Blitvich Source Type: research

Pediatric Medicaid Visits for Soil-Transmitted Helminth Infections in the Black Belt Region-Alabama, 2010-2018
We describe pediatric Medicaid STH visits in Alabama and compare STH visit rates in Black Belt counties with those of non-Black Belt counties. Alabama Medicaid visit claims among children aged 0-18 years who received an STH diagnosis during January 2010-December 2018 were examined. STH-related pediatric visits were uncommon, but several counties with higher STH rates were identified. Visit rates did not differ meaningfully when comparing Black Belt with non-Black Belt region counties (rate ratio: 1.10; 95% CI: 0.73-1.64). Additional studies examining STH prevalence among children living in communities at risk for STH in Al...
Source: The American Journal of Tropical Medicine and Hygiene - January 24, 2022 Category: Tropical Medicine Authors: Guillermo V Sanchez Anna J Blackstock Sherri L Davidson Source Type: research

Examining the Intersection between Gender, Community Health Workers, and Vector Control Policies: A Text Mining Literature Review
Am J Trop Med Hyg. 2022 Jan 24:tpmd210619. doi: 10.4269/ajtmh.21-0619. Online ahead of print.ABSTRACTGender intersects with healthcare systems; this is equally true for arboviral vector control efforts. However, there is as yet no comprehensive analysis as to how vector control is gendered. Hence, our objective is to provide the first thematic scoping and spatial distribution of the literature on gender, community health workers, and vector control. The authors use a systematic review approach to collect the academic literature on gender, community health workers, and vector control in Web of Science, Scopus, and PubMed (7...
Source: The American Journal of Tropical Medicine and Hygiene - January 24, 2022 Category: Tropical Medicine Authors: Ana De Menezes Ana Carolina Nunes Denise Nacif Pimenta Gabriela Lotta Theresia Nkya Morgana Martins Krieger Brunah Schall Clare Wenham Source Type: research

Ulcerative Lesion Caused by Inoculation of Leishmanin
Am J Trop Med Hyg. 2022 Jan 24:tpmd201248. doi: 10.4269/ajtmh.20-1248. Online ahead of print.NO ABSTRACTPMID:35073507 | DOI:10.4269/ajtmh.20-1248 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - January 24, 2022 Category: Tropical Medicine Authors: Jes ús Rojas-Jaimes Source Type: research

Case Report: COVID-19 Infection and Cervical Artery Dissection
Am J Trop Med Hyg. 2022 Jan 24:tpmd210999. doi: 10.4269/ajtmh.21-0999. Online ahead of print.ABSTRACTA 45-year-old woman presented 3 days after symptom resolution from a COVID-19 infection with a left vertebral artery dissection with no known preceding trauma or underlying disposition. She subsequently suffered a left lateral medullary stroke 15 hours after her initial presentation. Cervical artery dissections (CeAD) can occur in the absence of trauma, and in some cases, infection may be a contributing factor. COVID-19 infection can cause an endotheliopathy and inflammatory response, which may contribute to intimal vessel ...
Source: The American Journal of Tropical Medicine and Hygiene - January 24, 2022 Category: Tropical Medicine Authors: Kaylynn Purdy Rebecca Long Glen Jickling Source Type: research

Effects of Temephos (Abate ®), Spinosad (Natular®), and Diflubenzuron on the Survival of Cyclopoid Copepods
Am J Trop Med Hyg. 2022 Jan 24:tpmd210818. doi: 10.4269/ajtmh.21-0818. Online ahead of print.ABSTRACTDracunculus medinensis, also known as the African Guinea worm, is the causative agent of dracunculiasis and the focus of the global Guinea Worm Eradication Program (GWEP). Transmission of D. medinensis to humans occurs primarily by drinking water containing cyclopoid copepods infected with third-stage D. medinensis larvae. A common intervention to interrupt transmission and decrease the number of copepods in infected water bodies is the application of the organophosphate larvicide Abate® (temephos). However, the use of ...
Source: The American Journal of Tropical Medicine and Hygiene - January 24, 2022 Category: Tropical Medicine Authors: Ryan Grunert Erin Box Kayla Garrett Michael Yabsley Christopher Cleveland Source Type: research

Lymphocutaneous Sporotrichosis
Am J Trop Med Hyg. 2022 Jan 24:tpmd211212. doi: 10.4269/ajtmh.21-1212. Online ahead of print.NO ABSTRACTPMID:35073510 | DOI:10.4269/ajtmh.21-1212 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - January 24, 2022 Category: Tropical Medicine Authors: Alvaro Schwalb Paloma M Carcamo Carlos Seas Source Type: research

Risk Factors of Septic Metastatic Infection among Patients with Klebsiella pneumoniae Liver Abscess in Singapore: A Case-Control Study
This study aimed to determine the risk factors associated with metastatic infection among patients with KPLA in Singapore. A retrospective case-control analysis among adult patients admitted to the National University Hospital with KPLA between 2013 and 2017 was conducted. Univariate and multivariate regression analysis was conducted. Of the 116 KPLA patients, 38.8% had pulmonary metastatic infection. Length of hospital stay (P = 0.001) and intensive care unit admissions (P = 0.044) were significantly longer and greater, respectively, among the patients with metastatic infection. Sepsis-induced hypotension (adjusted odds r...
Source: The American Journal of Tropical Medicine and Hygiene - January 24, 2022 Category: Tropical Medicine Authors: Shilpa Mukherjee Sophia Archuleta Junxiong Pang Source Type: research

Evidence of Coinfections between SARS-CoV-2 and Select Arboviruses in Guerrero, Mexico, 2020-2021
Am J Trop Med Hyg. 2022 Jan 24:tpmd211216. doi: 10.4269/ajtmh.21-1216. Online ahead of print.ABSTRACTWe provide evidence of concurrent and close sequential infections between SARS-CoV-2 and select arboviruses-namely, chikungunya virus (CHIKV); dengue viruses 1, 2, and 3 (DENV1-3), and Zika virus (ZIKV)-in patients in Guerrero, southwest Mexico, in 2020-2021. The study population consisted of 176 febrile patients with laboratory evidence of SARS-CoV-2 infection. Sera from all patients were serologically and antigenically tested for seven arboviruses known to occur in Guerrero. Eighteen patients contained CHIKV IgM, six of w...
Source: The American Journal of Tropical Medicine and Hygiene - January 24, 2022 Category: Tropical Medicine Authors: Daniel Nunez-Avellaneda Fabian R Villag ómez Julio C Villegas-Pineda Jacqueline Barrios-Palacios Ma Isabel Salazar Carlos Machain-Williams Bradley J Blitvich Source Type: research

Case Report: Hantavirus Cardiopulmonary Syndrome Diagnostic in the Face of the COVID-19 Pandemic
We describe a fatal case of HCPS in a 24-year-old man who was hospitalized with fever, hemoconcentration, thrombocytopenia, leukocytosis, dry cough and a bilateral diffuse alveolar pulmonary infiltrate during the emergence of the COVID-19 pandemic in Brazil. HCPS needs to be ruled out in patients with clinical manifestations compatible with respiratory infections such as influenza and COVID-19.PMID:35045387 | DOI:10.4269/ajtmh.21-0637 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - January 19, 2022 Category: Tropical Medicine Authors: Elba Regina Sampaio de Lemos Jorlan Fernandes Thayssa Alves Coelho Liana Ogino Lumi Jos é Antônio Rodrigues Rosa Let ícia Biasus Zenaida Marion Alves Nunes D óris Bercht Brack Renata Carvalho de Oliveira Source Type: research

Case Report: Hantavirus Cardiopulmonary Syndrome Diagnostic in the Face of the COVID-19 Pandemic
We describe a fatal case of HCPS in a 24-year-old man who was hospitalized with fever, hemoconcentration, thrombocytopenia, leukocytosis, dry cough and a bilateral diffuse alveolar pulmonary infiltrate during the emergence of the COVID-19 pandemic in Brazil. HCPS needs to be ruled out in patients with clinical manifestations compatible with respiratory infections such as influenza and COVID-19.PMID:35045387 | DOI:10.4269/ajtmh.21-0637 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - January 19, 2022 Category: Tropical Medicine Authors: Elba Regina Sampaio de Lemos Jorlan Fernandes Thayssa Alves Coelho Liana Ogino Lumi Jos é Antônio Rodrigues Rosa Let ícia Biasus Zenaida Marion Alves Nunes D óris Bercht Brack Renata Carvalho de Oliveira Source Type: research

Case Report: Hantavirus Cardiopulmonary Syndrome Diagnostic in the Face of the COVID-19 Pandemic
We describe a fatal case of HCPS in a 24-year-old man who was hospitalized with fever, hemoconcentration, thrombocytopenia, leukocytosis, dry cough and a bilateral diffuse alveolar pulmonary infiltrate during the emergence of the COVID-19 pandemic in Brazil. HCPS needs to be ruled out in patients with clinical manifestations compatible with respiratory infections such as influenza and COVID-19.PMID:35045387 | DOI:10.4269/ajtmh.21-0637 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - January 19, 2022 Category: Tropical Medicine Authors: Elba Regina Sampaio de Lemos Jorlan Fernandes Thayssa Alves Coelho Liana Ogino Lumi Jos é Antônio Rodrigues Rosa Let ícia Biasus Zenaida Marion Alves Nunes D óris Bercht Brack Renata Carvalho de Oliveira Source Type: research

Case Report: Hantavirus Cardiopulmonary Syndrome Diagnostic in the Face of the COVID-19 Pandemic
We describe a fatal case of HCPS in a 24-year-old man who was hospitalized with fever, hemoconcentration, thrombocytopenia, leukocytosis, dry cough and a bilateral diffuse alveolar pulmonary infiltrate during the emergence of the COVID-19 pandemic in Brazil. HCPS needs to be ruled out in patients with clinical manifestations compatible with respiratory infections such as influenza and COVID-19.PMID:35045387 | DOI:10.4269/ajtmh.21-0637 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - January 19, 2022 Category: Tropical Medicine Authors: Elba Regina Sampaio de Lemos Jorlan Fernandes Thayssa Alves Coelho Liana Ogino Lumi Jos é Antônio Rodrigues Rosa Let ícia Biasus Zenaida Marion Alves Nunes D óris Bercht Brack Renata Carvalho de Oliveira Source Type: research

Case Report: Hantavirus Cardiopulmonary Syndrome Diagnostic in the Face of the COVID-19 Pandemic
We describe a fatal case of HCPS in a 24-year-old man who was hospitalized with fever, hemoconcentration, thrombocytopenia, leukocytosis, dry cough and a bilateral diffuse alveolar pulmonary infiltrate during the emergence of the COVID-19 pandemic in Brazil. HCPS needs to be ruled out in patients with clinical manifestations compatible with respiratory infections such as influenza and COVID-19.PMID:35045387 | DOI:10.4269/ajtmh.21-0637 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - January 19, 2022 Category: Tropical Medicine Authors: Elba Regina Sampaio de Lemos Jorlan Fernandes Thayssa Alves Coelho Liana Ogino Lumi Jos é Antônio Rodrigues Rosa Let ícia Biasus Zenaida Marion Alves Nunes D óris Bercht Brack Renata Carvalho de Oliveira Source Type: research

Comparison of Different Mosquito Traps for Zoonotic Arbovirus Vectors in Papua New Guinea
This study represents the first assessment of trapping devices for zoonotic arbovirus vectors in PNG. We recommend the CDC _UV trap for future monitoring and surveillance of infectious arboviral vector programs in PNG.PMID:35026726 | DOI:10.4269/ajtmh.21-0640 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Joelyn Goi Melanie Koinari Sakur Muker Rebecca Vinit William Pomat David Williams Stephan Karl Source Type: research

A Novel Malaria Lateral Flow Assay for Detecting Plasmodium falciparum Lactose Dehydrogenase in Busia, Uganda
Am J Trop Med Hyg. 2022 Jan 17:tpmd210956. doi: 10.4269/ajtmh.21-0956. Online ahead of print.ABSTRACTRapid diagnostic tests (RDTs) for Plasmodium falciparum commonly detect histidine-rich protein 2 (HRP-2), but HRP-2 deletions are increasingly recognized. We evaluated a prototype test detecting parasite lactate dehydrogenase (pLDH) and compared it to commercially available RDTs at a health facility in Uganda, using quantitative polymerase chain reaction as a gold standard. The prototype pLDH test had a high sensitivity for infections with at least 100 parasites/µL (98%), comparable to HRP-2, and greater than an exist...
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Christine M Bachman David M Cate Ben Grant Stephen Burkot Jerry Mulondo Helen V Hsieh Martin Chamai Bakar Odongo Peter Olwoch Mayimuna Nalubega Harriet Ochokoru Joseph Kasozi John Ategeka Kevin P Nichols Bernhard H Weigl Bryan Greenhouse Source Type: research

Natural Acquired Immunity to Malaria Antigens among Pregnant Women with Hemoglobin C Trait
Am J Trop Med Hyg. 2022 Jan 17:tpmd211039. doi: 10.4269/ajtmh.21-1039. Online ahead of print.ABSTRACTHemoglobin C is the second most common structural hemoglobinopathy in Africa, and carriers have a reduced risk of severe malaria. However, the effect of HbAC on the antibody response to malaria antigens in pregnancy has not been studied. Here, we measured PfEMP1-specific antibodCLUR in plasma samples from 74 Beninese pregnant women with either HbAA or HbAC. IgG-mediated inhibition of VAR2CSA+ infected erythrocytes adhesion to chondroitin sulfate A (CSA) was also tested. PfEMP1-specific IgG levels to VAR2CSA were significant...
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Mary Lopez-Perez Firmine Viwami Justin Doritchamou Nicaise Tuikue Ndam Lars Hviid Source Type: research

The Effect of Healthcare Worker Density on Maternal Health Service Utilization in Sub-Saharan Africa
This study evaluates the relationship between physician and nurse/midwife densities and the use of key maternal health services across sub-Saharan Africa (SSA). The authors matched individual-level maternal health service indicators from Demographic and Health Surveys between 2008 and 2017, to country-level physician and nurse/midwife per-capita densities, across 35 SSA countries. The authors performed univariate and multivariate probit regression analyses to evaluate the association between healthcare worker (HCW) densities and facility births as our primary outcome and with additional ANC services as secondary outcomes. ...
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Joelle I Rosser Kelly Z Aluri Arielle Kempinsky Shannon Richardson Eran Bendavid Source Type: research

Case Report: First Successful Treatment of Acanthamoeba Brain Abscess with Combination Surgical Excision and Miltefosine-Led Antimicrobial Therapy
We report a case in northern Australia of an immunosuppressed 57-year-old man who presented with diarrhea and weight loss, and was diagnosed with multiple Acanthamoeba brain abscesses after neurological deterioration. This case is the first successful treatment with surgical excision followed by combination antimicrobial therapy including miltefosine. This case was treated initially as nocardiosis or melioidosis, emphasizing the importance of considering differentials such as Acanthamoeba during workup of atypical infection. We present a literature review of the 14 Acanthamoeba brain abscess cases reported in the English l...
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Anson Chan Simon Smith Edwin Tan Sarin Kuruvath Source Type: research

HIV Infection Is an Independent Predictor of Mortality Among Adults with Reduced Level of Consciousness in Uganda
Am J Trop Med Hyg. 2022 Jan 17:tpmd210813. doi: 10.4269/ajtmh.21-0813. Online ahead of print.ABSTRACTThe clinical epidemiology of adults admitted with reduced level of consciousness (LOC) in sub-Saharan Africa (SSA) and the impact of HIV infection on the risk of mortality in this population is unknown. We secondarily analyzed data from a cohort study that enrolled 359 consecutive adults with reduced LOC presenting to Mbarara Regional Hospital in Uganda with the aim of comparing the prognostic utility of the Full Outline of Unresponsiveness (FOUR) score to the Glasgow Coma Scale (GCS) Score. For this analysis, we included 3...
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Amir A Mbonde Lydia Mbatidde Bart M Demaerschalk Abdirahim A Aden Nan Zhang Richard Butterfield Rose Muhindo Adrian Kayanja Cumara B O'Carroll Source Type: research

Comparison of Different Mosquito Traps for Zoonotic Arbovirus Vectors in Papua New Guinea
This study represents the first assessment of trapping devices for zoonotic arbovirus vectors in PNG. We recommend the CDC _UV trap for future monitoring and surveillance of infectious arboviral vector programs in PNG.PMID:35026726 | DOI:10.4269/ajtmh.21-0640 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Joelyn Goi Melanie Koinari Sakur Muker Rebecca Vinit William Pomat David Williams Stephan Karl Source Type: research

A Novel Malaria Lateral Flow Assay for Detecting Plasmodium falciparum Lactose Dehydrogenase in Busia, Uganda
Am J Trop Med Hyg. 2022 Jan 17:tpmd210956. doi: 10.4269/ajtmh.21-0956. Online ahead of print.ABSTRACTRapid diagnostic tests (RDTs) for Plasmodium falciparum commonly detect histidine-rich protein 2 (HRP-2), but HRP-2 deletions are increasingly recognized. We evaluated a prototype test detecting parasite lactate dehydrogenase (pLDH) and compared it to commercially available RDTs at a health facility in Uganda, using quantitative polymerase chain reaction as a gold standard. The prototype pLDH test had a high sensitivity for infections with at least 100 parasites/µL (98%), comparable to HRP-2, and greater than an exist...
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Christine M Bachman David M Cate Ben Grant Stephen Burkot Jerry Mulondo Helen V Hsieh Martin Chamai Bakar Odongo Peter Olwoch Mayimuna Nalubega Harriet Ochokoru Joseph Kasozi John Ategeka Kevin P Nichols Bernhard H Weigl Bryan Greenhouse Source Type: research

Natural Acquired Immunity to Malaria Antigens among Pregnant Women with Hemoglobin C Trait
Am J Trop Med Hyg. 2022 Jan 17:tpmd211039. doi: 10.4269/ajtmh.21-1039. Online ahead of print.ABSTRACTHemoglobin C is the second most common structural hemoglobinopathy in Africa, and carriers have a reduced risk of severe malaria. However, the effect of HbAC on the antibody response to malaria antigens in pregnancy has not been studied. Here, we measured PfEMP1-specific antibodCLUR in plasma samples from 74 Beninese pregnant women with either HbAA or HbAC. IgG-mediated inhibition of VAR2CSA+ infected erythrocytes adhesion to chondroitin sulfate A (CSA) was also tested. PfEMP1-specific IgG levels to VAR2CSA were significant...
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Mary Lopez-Perez Firmine Viwami Justin Doritchamou Nicaise Tuikue Ndam Lars Hviid Source Type: research

The Effect of Healthcare Worker Density on Maternal Health Service Utilization in Sub-Saharan Africa
This study evaluates the relationship between physician and nurse/midwife densities and the use of key maternal health services across sub-Saharan Africa (SSA). The authors matched individual-level maternal health service indicators from Demographic and Health Surveys between 2008 and 2017, to country-level physician and nurse/midwife per-capita densities, across 35 SSA countries. The authors performed univariate and multivariate probit regression analyses to evaluate the association between healthcare worker (HCW) densities and facility births as our primary outcome and with additional ANC services as secondary outcomes. ...
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Joelle I Rosser Kelly Z Aluri Arielle Kempinsky Shannon Richardson Eran Bendavid Source Type: research

Case Report: First Successful Treatment of Acanthamoeba Brain Abscess with Combination Surgical Excision and Miltefosine-Led Antimicrobial Therapy
We report a case in northern Australia of an immunosuppressed 57-year-old man who presented with diarrhea and weight loss, and was diagnosed with multiple Acanthamoeba brain abscesses after neurological deterioration. This case is the first successful treatment with surgical excision followed by combination antimicrobial therapy including miltefosine. This case was treated initially as nocardiosis or melioidosis, emphasizing the importance of considering differentials such as Acanthamoeba during workup of atypical infection. We present a literature review of the 14 Acanthamoeba brain abscess cases reported in the English l...
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Anson Chan Simon Smith Edwin Tan Sarin Kuruvath Source Type: research

HIV Infection Is an Independent Predictor of Mortality Among Adults with Reduced Level of Consciousness in Uganda
Am J Trop Med Hyg. 2022 Jan 17:tpmd210813. doi: 10.4269/ajtmh.21-0813. Online ahead of print.ABSTRACTThe clinical epidemiology of adults admitted with reduced level of consciousness (LOC) in sub-Saharan Africa (SSA) and the impact of HIV infection on the risk of mortality in this population is unknown. We secondarily analyzed data from a cohort study that enrolled 359 consecutive adults with reduced LOC presenting to Mbarara Regional Hospital in Uganda with the aim of comparing the prognostic utility of the Full Outline of Unresponsiveness (FOUR) score to the Glasgow Coma Scale (GCS) Score. For this analysis, we included 3...
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Amir A Mbonde Lydia Mbatidde Bart M Demaerschalk Abdirahim A Aden Nan Zhang Richard Butterfield Rose Muhindo Adrian Kayanja Cumara B O'Carroll Source Type: research

Comparison of Different Mosquito Traps for Zoonotic Arbovirus Vectors in Papua New Guinea
This study represents the first assessment of trapping devices for zoonotic arbovirus vectors in PNG. We recommend the CDC _UV trap for future monitoring and surveillance of infectious arboviral vector programs in PNG.PMID:35026726 | DOI:10.4269/ajtmh.21-0640 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Joelyn Goi Melanie Koinari Sakur Muker Rebecca Vinit William Pomat David Williams Stephan Karl Source Type: research

A Novel Malaria Lateral Flow Assay for Detecting Plasmodium falciparum Lactose Dehydrogenase in Busia, Uganda
Am J Trop Med Hyg. 2022 Jan 17:tpmd210956. doi: 10.4269/ajtmh.21-0956. Online ahead of print.ABSTRACTRapid diagnostic tests (RDTs) for Plasmodium falciparum commonly detect histidine-rich protein 2 (HRP-2), but HRP-2 deletions are increasingly recognized. We evaluated a prototype test detecting parasite lactate dehydrogenase (pLDH) and compared it to commercially available RDTs at a health facility in Uganda, using quantitative polymerase chain reaction as a gold standard. The prototype pLDH test had a high sensitivity for infections with at least 100 parasites/µL (98%), comparable to HRP-2, and greater than an exist...
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Christine M Bachman David M Cate Ben Grant Stephen Burkot Jerry Mulondo Helen V Hsieh Martin Chamai Bakar Odongo Peter Olwoch Mayimuna Nalubega Harriet Ochokoru Joseph Kasozi John Ategeka Kevin P Nichols Bernhard H Weigl Bryan Greenhouse Source Type: research

Natural Acquired Immunity to Malaria Antigens among Pregnant Women with Hemoglobin C Trait
Am J Trop Med Hyg. 2022 Jan 17:tpmd211039. doi: 10.4269/ajtmh.21-1039. Online ahead of print.ABSTRACTHemoglobin C is the second most common structural hemoglobinopathy in Africa, and carriers have a reduced risk of severe malaria. However, the effect of HbAC on the antibody response to malaria antigens in pregnancy has not been studied. Here, we measured PfEMP1-specific antibodCLUR in plasma samples from 74 Beninese pregnant women with either HbAA or HbAC. IgG-mediated inhibition of VAR2CSA+ infected erythrocytes adhesion to chondroitin sulfate A (CSA) was also tested. PfEMP1-specific IgG levels to VAR2CSA were significant...
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Mary Lopez-Perez Firmine Viwami Justin Doritchamou Nicaise Tuikue Ndam Lars Hviid Source Type: research

The Effect of Healthcare Worker Density on Maternal Health Service Utilization in Sub-Saharan Africa
This study evaluates the relationship between physician and nurse/midwife densities and the use of key maternal health services across sub-Saharan Africa (SSA). The authors matched individual-level maternal health service indicators from Demographic and Health Surveys between 2008 and 2017, to country-level physician and nurse/midwife per-capita densities, across 35 SSA countries. The authors performed univariate and multivariate probit regression analyses to evaluate the association between healthcare worker (HCW) densities and facility births as our primary outcome and with additional ANC services as secondary outcomes. ...
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Joelle I Rosser Kelly Z Aluri Arielle Kempinsky Shannon Richardson Eran Bendavid Source Type: research

Case Report: First Successful Treatment of Acanthamoeba Brain Abscess with Combination Surgical Excision and Miltefosine-Led Antimicrobial Therapy
We report a case in northern Australia of an immunosuppressed 57-year-old man who presented with diarrhea and weight loss, and was diagnosed with multiple Acanthamoeba brain abscesses after neurological deterioration. This case is the first successful treatment with surgical excision followed by combination antimicrobial therapy including miltefosine. This case was treated initially as nocardiosis or melioidosis, emphasizing the importance of considering differentials such as Acanthamoeba during workup of atypical infection. We present a literature review of the 14 Acanthamoeba brain abscess cases reported in the English l...
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Anson Chan Simon Smith Edwin Tan Sarin Kuruvath Source Type: research

HIV Infection Is an Independent Predictor of Mortality Among Adults with Reduced Level of Consciousness in Uganda
Am J Trop Med Hyg. 2022 Jan 17:tpmd210813. doi: 10.4269/ajtmh.21-0813. Online ahead of print.ABSTRACTThe clinical epidemiology of adults admitted with reduced level of consciousness (LOC) in sub-Saharan Africa (SSA) and the impact of HIV infection on the risk of mortality in this population is unknown. We secondarily analyzed data from a cohort study that enrolled 359 consecutive adults with reduced LOC presenting to Mbarara Regional Hospital in Uganda with the aim of comparing the prognostic utility of the Full Outline of Unresponsiveness (FOUR) score to the Glasgow Coma Scale (GCS) Score. For this analysis, we included 3...
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Amir A Mbonde Lydia Mbatidde Bart M Demaerschalk Abdirahim A Aden Nan Zhang Richard Butterfield Rose Muhindo Adrian Kayanja Cumara B O'Carroll Source Type: research

Comparison of Different Mosquito Traps for Zoonotic Arbovirus Vectors in Papua New Guinea
This study represents the first assessment of trapping devices for zoonotic arbovirus vectors in PNG. We recommend the CDC _UV trap for future monitoring and surveillance of infectious arboviral vector programs in PNG.PMID:35026726 | DOI:10.4269/ajtmh.21-0640 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Joelyn Goi Melanie Koinari Sakur Muker Rebecca Vinit William Pomat David Williams Stephan Karl Source Type: research

A Novel Malaria Lateral Flow Assay for Detecting Plasmodium falciparum Lactose Dehydrogenase in Busia, Uganda
Am J Trop Med Hyg. 2022 Jan 17:tpmd210956. doi: 10.4269/ajtmh.21-0956. Online ahead of print.ABSTRACTRapid diagnostic tests (RDTs) for Plasmodium falciparum commonly detect histidine-rich protein 2 (HRP-2), but HRP-2 deletions are increasingly recognized. We evaluated a prototype test detecting parasite lactate dehydrogenase (pLDH) and compared it to commercially available RDTs at a health facility in Uganda, using quantitative polymerase chain reaction as a gold standard. The prototype pLDH test had a high sensitivity for infections with at least 100 parasites/µL (98%), comparable to HRP-2, and greater than an exist...
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Christine M Bachman David M Cate Ben Grant Stephen Burkot Jerry Mulondo Helen V Hsieh Martin Chamai Bakar Odongo Peter Olwoch Mayimuna Nalubega Harriet Ochokoru Joseph Kasozi John Ategeka Kevin P Nichols Bernhard H Weigl Bryan Greenhouse Source Type: research

Natural Acquired Immunity to Malaria Antigens among Pregnant Women with Hemoglobin C Trait
Am J Trop Med Hyg. 2022 Jan 17:tpmd211039. doi: 10.4269/ajtmh.21-1039. Online ahead of print.ABSTRACTHemoglobin C is the second most common structural hemoglobinopathy in Africa, and carriers have a reduced risk of severe malaria. However, the effect of HbAC on the antibody response to malaria antigens in pregnancy has not been studied. Here, we measured PfEMP1-specific antibodCLUR in plasma samples from 74 Beninese pregnant women with either HbAA or HbAC. IgG-mediated inhibition of VAR2CSA+ infected erythrocytes adhesion to chondroitin sulfate A (CSA) was also tested. PfEMP1-specific IgG levels to VAR2CSA were significant...
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Mary Lopez-Perez Firmine Viwami Justin Doritchamou Nicaise Tuikue Ndam Lars Hviid Source Type: research

The Effect of Healthcare Worker Density on Maternal Health Service Utilization in Sub-Saharan Africa
This study evaluates the relationship between physician and nurse/midwife densities and the use of key maternal health services across sub-Saharan Africa (SSA). The authors matched individual-level maternal health service indicators from Demographic and Health Surveys between 2008 and 2017, to country-level physician and nurse/midwife per-capita densities, across 35 SSA countries. The authors performed univariate and multivariate probit regression analyses to evaluate the association between healthcare worker (HCW) densities and facility births as our primary outcome and with additional ANC services as secondary outcomes. ...
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Joelle I Rosser Kelly Z Aluri Arielle Kempinsky Shannon Richardson Eran Bendavid Source Type: research

Case Report: First Successful Treatment of Acanthamoeba Brain Abscess with Combination Surgical Excision and Miltefosine-Led Antimicrobial Therapy
We report a case in northern Australia of an immunosuppressed 57-year-old man who presented with diarrhea and weight loss, and was diagnosed with multiple Acanthamoeba brain abscesses after neurological deterioration. This case is the first successful treatment with surgical excision followed by combination antimicrobial therapy including miltefosine. This case was treated initially as nocardiosis or melioidosis, emphasizing the importance of considering differentials such as Acanthamoeba during workup of atypical infection. We present a literature review of the 14 Acanthamoeba brain abscess cases reported in the English l...
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Anson Chan Simon Smith Edwin Tan Sarin Kuruvath Source Type: research

HIV Infection Is an Independent Predictor of Mortality Among Adults with Reduced Level of Consciousness in Uganda
Am J Trop Med Hyg. 2022 Jan 17:tpmd210813. doi: 10.4269/ajtmh.21-0813. Online ahead of print.ABSTRACTThe clinical epidemiology of adults admitted with reduced level of consciousness (LOC) in sub-Saharan Africa (SSA) and the impact of HIV infection on the risk of mortality in this population is unknown. We secondarily analyzed data from a cohort study that enrolled 359 consecutive adults with reduced LOC presenting to Mbarara Regional Hospital in Uganda with the aim of comparing the prognostic utility of the Full Outline of Unresponsiveness (FOUR) score to the Glasgow Coma Scale (GCS) Score. For this analysis, we included 3...
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Amir A Mbonde Lydia Mbatidde Bart M Demaerschalk Abdirahim A Aden Nan Zhang Richard Butterfield Rose Muhindo Adrian Kayanja Cumara B O'Carroll Source Type: research

Comparison of Different Mosquito Traps for Zoonotic Arbovirus Vectors in Papua New Guinea
This study represents the first assessment of trapping devices for zoonotic arbovirus vectors in PNG. We recommend the CDC _UV trap for future monitoring and surveillance of infectious arboviral vector programs in PNG.PMID:35026726 | DOI:10.4269/ajtmh.21-0640 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Joelyn Goi Melanie Koinari Sakur Muker Rebecca Vinit William Pomat David Williams Stephan Karl Source Type: research

A Novel Malaria Lateral Flow Assay for Detecting Plasmodium falciparum Lactose Dehydrogenase in Busia, Uganda
Am J Trop Med Hyg. 2022 Jan 17:tpmd210956. doi: 10.4269/ajtmh.21-0956. Online ahead of print.ABSTRACTRapid diagnostic tests (RDTs) for Plasmodium falciparum commonly detect histidine-rich protein 2 (HRP-2), but HRP-2 deletions are increasingly recognized. We evaluated a prototype test detecting parasite lactate dehydrogenase (pLDH) and compared it to commercially available RDTs at a health facility in Uganda, using quantitative polymerase chain reaction as a gold standard. The prototype pLDH test had a high sensitivity for infections with at least 100 parasites/µL (98%), comparable to HRP-2, and greater than an exist...
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Christine M Bachman David M Cate Ben Grant Stephen Burkot Jerry Mulondo Helen V Hsieh Martin Chamai Bakar Odongo Peter Olwoch Mayimuna Nalubega Harriet Ochokoru Joseph Kasozi John Ategeka Kevin P Nichols Bernhard H Weigl Bryan Greenhouse Source Type: research

Natural Acquired Immunity to Malaria Antigens among Pregnant Women with Hemoglobin C Trait
Am J Trop Med Hyg. 2022 Jan 17:tpmd211039. doi: 10.4269/ajtmh.21-1039. Online ahead of print.ABSTRACTHemoglobin C is the second most common structural hemoglobinopathy in Africa, and carriers have a reduced risk of severe malaria. However, the effect of HbAC on the antibody response to malaria antigens in pregnancy has not been studied. Here, we measured PfEMP1-specific antibodCLUR in plasma samples from 74 Beninese pregnant women with either HbAA or HbAC. IgG-mediated inhibition of VAR2CSA+ infected erythrocytes adhesion to chondroitin sulfate A (CSA) was also tested. PfEMP1-specific IgG levels to VAR2CSA were significant...
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Mary Lopez-Perez Firmine Viwami Justin Doritchamou Nicaise Tuikue Ndam Lars Hviid Source Type: research

The Effect of Healthcare Worker Density on Maternal Health Service Utilization in Sub-Saharan Africa
This study evaluates the relationship between physician and nurse/midwife densities and the use of key maternal health services across sub-Saharan Africa (SSA). The authors matched individual-level maternal health service indicators from Demographic and Health Surveys between 2008 and 2017, to country-level physician and nurse/midwife per-capita densities, across 35 SSA countries. The authors performed univariate and multivariate probit regression analyses to evaluate the association between healthcare worker (HCW) densities and facility births as our primary outcome and with additional ANC services as secondary outcomes. ...
Source: The American Journal of Tropical Medicine and Hygiene - January 13, 2022 Category: Tropical Medicine Authors: Joelle I Rosser Kelly Z Aluri Arielle Kempinsky Shannon Richardson Eran Bendavid Source Type: research