T cell subsets and environmental factors in Citrobacter rodentium infection
Curr Opin Microbiol. 2021 Jul 20;63:92-97. doi: 10.1016/j.mib.2021.06.006. Online ahead of print.ABSTRACTInfection with Citrobacter rodentium constitutes an attack on the intestinal barrier and results in concerted action by innate and adaptive immune responses to limit bacterial translocation and destroy those bacteria that have breached the intestinal barrier. Among the many immune cell types that are involved in the defence against this infection, Th17 cells as the major producers of the barrier protective cytokine IL-22 during the adaptive phase of the response are most numerous. Their extensive plasticity furthermore ...
Source: Current Opinion in Microbiology - July 23, 2021 Category: Microbiology Authors: Brigitta Stockinger Source Type: research

Group 3 innate lymphoid cells mediate host defense against attaching and effacing pathogens
Curr Opin Microbiol. 2021 Jul 15;63:83-91. doi: 10.1016/j.mib.2021.06.005. Online ahead of print.ABSTRACTGroup 3 innate lymphoid cells (ILC3) are innate effector cells that have essential roles in lymphoid organogenesis and maintenance of tissue homeostasis under steady-state and pathogenic conditions. ILC3 also promote immune defense, notably during bacterial breach of epithelial barriers, including those caused by attaching and effacing (A/E) pathogens for which Citrobacter rodentium infection in mice is a relevant pre-clinical model. Through their ability to sustain interactions with tissue-resident immune cells, epithe...
Source: Current Opinion in Microbiology - July 18, 2021 Category: Microbiology Authors: Ang élique Jarade James P Di Santo Nicolas Serafini Source Type: research

Group 3 innate lymphoid cells mediate host defense against attaching and effacing pathogens
Curr Opin Microbiol. 2021 Jul 15;63:83-91. doi: 10.1016/j.mib.2021.06.005. Online ahead of print.ABSTRACTGroup 3 innate lymphoid cells (ILC3) are innate effector cells that have essential roles in lymphoid organogenesis and maintenance of tissue homeostasis under steady-state and pathogenic conditions. ILC3 also promote immune defense, notably during bacterial breach of epithelial barriers, including those caused by attaching and effacing (A/E) pathogens for which Citrobacter rodentium infection in mice is a relevant pre-clinical model. Through their ability to sustain interactions with tissue-resident immune cells, epithe...
Source: Current Opinion in Microbiology - July 18, 2021 Category: Microbiology Authors: Ang élique Jarade James P Di Santo Nicolas Serafini Source Type: research

Group 3 innate lymphoid cells mediate host defense against attaching and effacing pathogens
Curr Opin Microbiol. 2021 Jul 15;63:83-91. doi: 10.1016/j.mib.2021.06.005. Online ahead of print.ABSTRACTGroup 3 innate lymphoid cells (ILC3) are innate effector cells that have essential roles in lymphoid organogenesis and maintenance of tissue homeostasis under steady-state and pathogenic conditions. ILC3 also promote immune defense, notably during bacterial breach of epithelial barriers, including those caused by attaching and effacing (A/E) pathogens for which Citrobacter rodentium infection in mice is a relevant pre-clinical model. Through their ability to sustain interactions with tissue-resident immune cells, epithe...
Source: Current Opinion in Microbiology - July 18, 2021 Category: Microbiology Authors: Ang élique Jarade James P Di Santo Nicolas Serafini Source Type: research

Group 3 innate lymphoid cells mediate host defense against attaching and effacing pathogens
Curr Opin Microbiol. 2021 Jul 15;63:83-91. doi: 10.1016/j.mib.2021.06.005. Online ahead of print.ABSTRACTGroup 3 innate lymphoid cells (ILC3) are innate effector cells that have essential roles in lymphoid organogenesis and maintenance of tissue homeostasis under steady-state and pathogenic conditions. ILC3 also promote immune defense, notably during bacterial breach of epithelial barriers, including those caused by attaching and effacing (A/E) pathogens for which Citrobacter rodentium infection in mice is a relevant pre-clinical model. Through their ability to sustain interactions with tissue-resident immune cells, epithe...
Source: Current Opinion in Microbiology - July 18, 2021 Category: Microbiology Authors: Ang élique Jarade James P Di Santo Nicolas Serafini Source Type: research

What's for dinner? How Citrobacter rodentium's metabolism helps it thrive in the competitive gut
Curr Opin Microbiol. 2021 Jul 6;63:76-82. doi: 10.1016/j.mib.2021.06.004. Online ahead of print.ABSTRACTEnteric bacterial infections impose a significant and global health burden on society, and their threat is increasing in concert with a rise in antibiotic resistance. There is thus a great need to quickly develop new antimicrobial treatments and interest is growing in targeting pathogen nutrition and metabolism. In this review, we highlight recent research on the metabolism of Citrobacter rodentium, a murine-specific relative of enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC). We focus on th...
Source: Current Opinion in Microbiology - July 9, 2021 Category: Microbiology Authors: Qiaochu Liang Bruce A Vallance Source Type: research

What's for dinner? How Citrobacter rodentium's metabolism helps it thrive in the competitive gut
Curr Opin Microbiol. 2021 Jul 6;63:76-82. doi: 10.1016/j.mib.2021.06.004. Online ahead of print.ABSTRACTEnteric bacterial infections impose a significant and global health burden on society, and their threat is increasing in concert with a rise in antibiotic resistance. There is thus a great need to quickly develop new antimicrobial treatments and interest is growing in targeting pathogen nutrition and metabolism. In this review, we highlight recent research on the metabolism of Citrobacter rodentium, a murine-specific relative of enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC). We focus on th...
Source: Current Opinion in Microbiology - July 9, 2021 Category: Microbiology Authors: Qiaochu Liang Bruce A Vallance Source Type: research

What's for dinner? How Citrobacter rodentium's metabolism helps it thrive in the competitive gut
Curr Opin Microbiol. 2021 Jul 6;63:76-82. doi: 10.1016/j.mib.2021.06.004. Online ahead of print.ABSTRACTEnteric bacterial infections impose a significant and global health burden on society, and their threat is increasing in concert with a rise in antibiotic resistance. There is thus a great need to quickly develop new antimicrobial treatments and interest is growing in targeting pathogen nutrition and metabolism. In this review, we highlight recent research on the metabolism of Citrobacter rodentium, a murine-specific relative of enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC). We focus on th...
Source: Current Opinion in Microbiology - July 9, 2021 Category: Microbiology Authors: Qiaochu Liang Bruce A Vallance Source Type: research

What's for dinner? How Citrobacter rodentium's metabolism helps it thrive in the competitive gut
Curr Opin Microbiol. 2021 Jul 6;63:76-82. doi: 10.1016/j.mib.2021.06.004. Online ahead of print.ABSTRACTEnteric bacterial infections impose a significant and global health burden on society, and their threat is increasing in concert with a rise in antibiotic resistance. There is thus a great need to quickly develop new antimicrobial treatments and interest is growing in targeting pathogen nutrition and metabolism. In this review, we highlight recent research on the metabolism of Citrobacter rodentium, a murine-specific relative of enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC). We focus on th...
Source: Current Opinion in Microbiology - July 9, 2021 Category: Microbiology Authors: Qiaochu Liang Bruce A Vallance Source Type: research

What's for dinner? How Citrobacter rodentium's metabolism helps it thrive in the competitive gut
Curr Opin Microbiol. 2021 Jul 6;63:76-82. doi: 10.1016/j.mib.2021.06.004. Online ahead of print.ABSTRACTEnteric bacterial infections impose a significant and global health burden on society, and their threat is increasing in concert with a rise in antibiotic resistance. There is thus a great need to quickly develop new antimicrobial treatments and interest is growing in targeting pathogen nutrition and metabolism. In this review, we highlight recent research on the metabolism of Citrobacter rodentium, a murine-specific relative of enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC). We focus on th...
Source: Current Opinion in Microbiology - July 9, 2021 Category: Microbiology Authors: Qiaochu Liang Bruce A Vallance Source Type: research

What's for dinner? How Citrobacter rodentium's metabolism helps it thrive in the competitive gut
Curr Opin Microbiol. 2021 Jul 6;63:76-82. doi: 10.1016/j.mib.2021.06.004. Online ahead of print.ABSTRACTEnteric bacterial infections impose a significant and global health burden on society, and their threat is increasing in concert with a rise in antibiotic resistance. There is thus a great need to quickly develop new antimicrobial treatments and interest is growing in targeting pathogen nutrition and metabolism. In this review, we highlight recent research on the metabolism of Citrobacter rodentium, a murine-specific relative of enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC). We focus on th...
Source: Current Opinion in Microbiology - July 9, 2021 Category: Microbiology Authors: Qiaochu Liang Bruce A Vallance Source Type: research

What's for dinner? How Citrobacter rodentium's metabolism helps it thrive in the competitive gut
Curr Opin Microbiol. 2021 Jul 6;63:76-82. doi: 10.1016/j.mib.2021.06.004. Online ahead of print.ABSTRACTEnteric bacterial infections impose a significant and global health burden on society, and their threat is increasing in concert with a rise in antibiotic resistance. There is thus a great need to quickly develop new antimicrobial treatments and interest is growing in targeting pathogen nutrition and metabolism. In this review, we highlight recent research on the metabolism of Citrobacter rodentium, a murine-specific relative of enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC). We focus on th...
Source: Current Opinion in Microbiology - July 9, 2021 Category: Microbiology Authors: Qiaochu Liang Bruce A Vallance Source Type: research

What's for dinner? How Citrobacter rodentium's metabolism helps it thrive in the competitive gut
Curr Opin Microbiol. 2021 Jul 6;63:76-82. doi: 10.1016/j.mib.2021.06.004. Online ahead of print.ABSTRACTEnteric bacterial infections impose a significant and global health burden on society, and their threat is increasing in concert with a rise in antibiotic resistance. There is thus a great need to quickly develop new antimicrobial treatments and interest is growing in targeting pathogen nutrition and metabolism. In this review, we highlight recent research on the metabolism of Citrobacter rodentium, a murine-specific relative of enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC). We focus on th...
Source: Current Opinion in Microbiology - July 9, 2021 Category: Microbiology Authors: Qiaochu Liang Bruce A Vallance Source Type: research

Transcriptional and metabolic regulation of EHEC and Citrobacter rodentium pathogenesis
Curr Opin Microbiol. 2021 Jul 2;63:70-75. doi: 10.1016/j.mib.2021.06.002. Online ahead of print.ABSTRACTEnterohaemorrhagic Escherichia coli (EHEC) is a gastrointestinal pathogen that colonizes the colonic epithelium of humans and ruminants using a Type Three Secretion System (T3SS). This system is indispensable for disease and is regulated in response to a plethora of host and microbiota derived signals. The murine pathogen, Citrobacter rodentium, has become an instrumental tool in studying EHEC infection mechanisms in vivo, given its natural ability to infect mice and reliance on the same colonisation machinery. Here, we ...
Source: Current Opinion in Microbiology - July 5, 2021 Category: Microbiology Authors: Kabo R Wale Curtis Cottam James Pr Connolly Andrew J Roe Source Type: research

Transcriptional and metabolic regulation of EHEC and Citrobacter rodentium pathogenesis
Curr Opin Microbiol. 2021 Jul 2;63:70-75. doi: 10.1016/j.mib.2021.06.002. Online ahead of print.ABSTRACTEnterohaemorrhagic Escherichia coli (EHEC) is a gastrointestinal pathogen that colonizes the colonic epithelium of humans and ruminants using a Type Three Secretion System (T3SS). This system is indispensable for disease and is regulated in response to a plethora of host and microbiota derived signals. The murine pathogen, Citrobacter rodentium, has become an instrumental tool in studying EHEC infection mechanisms in vivo, given its natural ability to infect mice and reliance on the same colonisation machinery. Here, we ...
Source: Current Opinion in Microbiology - July 5, 2021 Category: Microbiology Authors: Kabo R Wale Curtis Cottam James Pr Connolly Andrew J Roe Source Type: research

Transcriptional and metabolic regulation of EHEC and Citrobacter rodentium pathogenesis
Curr Opin Microbiol. 2021 Jul 2;63:70-75. doi: 10.1016/j.mib.2021.06.002. Online ahead of print.ABSTRACTEnterohaemorrhagic Escherichia coli (EHEC) is a gastrointestinal pathogen that colonizes the colonic epithelium of humans and ruminants using a Type Three Secretion System (T3SS). This system is indispensable for disease and is regulated in response to a plethora of host and microbiota derived signals. The murine pathogen, Citrobacter rodentium, has become an instrumental tool in studying EHEC infection mechanisms in vivo, given its natural ability to infect mice and reliance on the same colonisation machinery. Here, we ...
Source: Current Opinion in Microbiology - July 5, 2021 Category: Microbiology Authors: Kabo R Wale Curtis Cottam James Pr Connolly Andrew J Roe Source Type: research

Transcriptional and metabolic regulation of EHEC and Citrobacter rodentium pathogenesis
Curr Opin Microbiol. 2021 Jul 2;63:70-75. doi: 10.1016/j.mib.2021.06.002. Online ahead of print.ABSTRACTEnterohaemorrhagic Escherichia coli (EHEC) is a gastrointestinal pathogen that colonizes the colonic epithelium of humans and ruminants using a Type Three Secretion System (T3SS). This system is indispensable for disease and is regulated in response to a plethora of host and microbiota derived signals. The murine pathogen, Citrobacter rodentium, has become an instrumental tool in studying EHEC infection mechanisms in vivo, given its natural ability to infect mice and reliance on the same colonisation machinery. Here, we ...
Source: Current Opinion in Microbiology - July 5, 2021 Category: Microbiology Authors: Kabo R Wale Curtis Cottam James Pr Connolly Andrew J Roe Source Type: research

Citrobacter rodentium infection at the gut-brain axis interface
Curr Opin Microbiol. 2021 Jul 1;63:59-65. doi: 10.1016/j.mib.2021.06.003. Online ahead of print.ABSTRACTThe gut-brain axis plays a critical role in the maintenance of the gastrointestinal tract homeostasis. Several enteric pathogens have developed strategies to sense neurochemical molecules to regulate their virulence in the gut. Additionally, there is growing evidence that gut dysbiosis can strongly affect host brain responses. Here we review different mechanisms that have been proposed to mediate gut-brain axis communication using Citrobacter rodentium, a natural murine enteric pathogen and one of the most widely used sm...
Source: Current Opinion in Microbiology - July 4, 2021 Category: Microbiology Authors: Fernando H Martins Santiago Cuesta Source Type: research

Mining for novel antibiotics
Curr Opin Microbiol. 2021 Jul 1;63:66-69. doi: 10.1016/j.mib.2021.06.001. Online ahead of print.NO ABSTRACTPMID:34217916 | DOI:10.1016/j.mib.2021.06.001 (Source: Current Opinion in Microbiology)
Source: Current Opinion in Microbiology - July 4, 2021 Category: Microbiology Authors: Justin R Randall Bryan W Davies Source Type: research

Salmonella pathogenesis and host-adaptation in farmed animals
Curr Opin Microbiol. 2021 Jun 24;63:52-58. doi: 10.1016/j.mib.2021.05.013. Online ahead of print.ABSTRACTSalmonella is an animal and zoonotic pathogen of global importance. Depending on pathogen and host factors, infections can be asymptomatic or involve acute gastroenteritis or invasive disease. Genomic signatures associated with host-range, tissue tropism or differential virulence of Salmonella enterica serovars, and their variants, have emerged. In turn, it is becoming feasible to predict invasive potential, host-adaptation and zoonotic risk of Salmonella from sequence data to improve outbreak investigation, risk assess...
Source: Current Opinion in Microbiology - June 27, 2021 Category: Microbiology Authors: Mark P Stevens Robert A Kingsley Source Type: research

Salmonella pathogenesis and host-adaptation in farmed animals
Curr Opin Microbiol. 2021 Jun 24;63:52-58. doi: 10.1016/j.mib.2021.05.013. Online ahead of print.ABSTRACTSalmonella is an animal and zoonotic pathogen of global importance. Depending on pathogen and host factors, infections can be asymptomatic or involve acute gastroenteritis or invasive disease. Genomic signatures associated with host-range, tissue tropism or differential virulence of Salmonella enterica serovars, and their variants, have emerged. In turn, it is becoming feasible to predict invasive potential, host-adaptation and zoonotic risk of Salmonella from sequence data to improve outbreak investigation, risk assess...
Source: Current Opinion in Microbiology - June 27, 2021 Category: Microbiology Authors: Mark P Stevens Robert A Kingsley Source Type: research

Salmonella pathogenesis and host-adaptation in farmed animals
Curr Opin Microbiol. 2021 Jun 24;63:52-58. doi: 10.1016/j.mib.2021.05.013. Online ahead of print.ABSTRACTSalmonella is an animal and zoonotic pathogen of global importance. Depending on pathogen and host factors, infections can be asymptomatic or involve acute gastroenteritis or invasive disease. Genomic signatures associated with host-range, tissue tropism or differential virulence of Salmonella enterica serovars, and their variants, have emerged. In turn, it is becoming feasible to predict invasive potential, host-adaptation and zoonotic risk of Salmonella from sequence data to improve outbreak investigation, risk assess...
Source: Current Opinion in Microbiology - June 27, 2021 Category: Microbiology Authors: Mark P Stevens Robert A Kingsley Source Type: research

Salmonella pathogenesis and host-adaptation in farmed animals
Curr Opin Microbiol. 2021 Jun 24;63:52-58. doi: 10.1016/j.mib.2021.05.013. Online ahead of print.ABSTRACTSalmonella is an animal and zoonotic pathogen of global importance. Depending on pathogen and host factors, infections can be asymptomatic or involve acute gastroenteritis or invasive disease. Genomic signatures associated with host-range, tissue tropism or differential virulence of Salmonella enterica serovars, and their variants, have emerged. In turn, it is becoming feasible to predict invasive potential, host-adaptation and zoonotic risk of Salmonella from sequence data to improve outbreak investigation, risk assess...
Source: Current Opinion in Microbiology - June 27, 2021 Category: Microbiology Authors: Mark P Stevens Robert A Kingsley Source Type: research

Salmonella pathogenesis and host-adaptation in farmed animals
Curr Opin Microbiol. 2021 Jun 24;63:52-58. doi: 10.1016/j.mib.2021.05.013. Online ahead of print.ABSTRACTSalmonella is an animal and zoonotic pathogen of global importance. Depending on pathogen and host factors, infections can be asymptomatic or involve acute gastroenteritis or invasive disease. Genomic signatures associated with host-range, tissue tropism or differential virulence of Salmonella enterica serovars, and their variants, have emerged. In turn, it is becoming feasible to predict invasive potential, host-adaptation and zoonotic risk of Salmonella from sequence data to improve outbreak investigation, risk assess...
Source: Current Opinion in Microbiology - June 27, 2021 Category: Microbiology Authors: Mark P Stevens Robert A Kingsley Source Type: research

Salmonella pathogenesis and host-adaptation in farmed animals
Curr Opin Microbiol. 2021 Jun 24;63:52-58. doi: 10.1016/j.mib.2021.05.013. Online ahead of print.ABSTRACTSalmonella is an animal and zoonotic pathogen of global importance. Depending on pathogen and host factors, infections can be asymptomatic or involve acute gastroenteritis or invasive disease. Genomic signatures associated with host-range, tissue tropism or differential virulence of Salmonella enterica serovars, and their variants, have emerged. In turn, it is becoming feasible to predict invasive potential, host-adaptation and zoonotic risk of Salmonella from sequence data to improve outbreak investigation, risk assess...
Source: Current Opinion in Microbiology - June 27, 2021 Category: Microbiology Authors: Mark P Stevens Robert A Kingsley Source Type: research

Biophysical approaches to understand and re-purpose bacterial microcompartments
Curr Opin Microbiol. 2021 Jun 21;63:43-51. doi: 10.1016/j.mib.2021.05.008. Online ahead of print.ABSTRACTBacterial microcompartments represent a modular class of prokaryotic organelles associated with metabolic processes. They harbor a congregation of enzymes that work in cascade within a small, confined volume. These sophisticated nano-engineered crafts of nature offer a tempting paradigm for the fabrication of biosynthetic nanoreactors. Repurposing bacterial microcompartments to develop nanostructures with desired functions requires a careful manipulation in their structural makeup and composition. This calls for a compr...
Source: Current Opinion in Microbiology - June 24, 2021 Category: Microbiology Authors: Gaurav Kumar Sharmistha Sinha Source Type: research

Biophysical approaches to understand and re-purpose bacterial microcompartments
Curr Opin Microbiol. 2021 Jun 21;63:43-51. doi: 10.1016/j.mib.2021.05.008. Online ahead of print.ABSTRACTBacterial microcompartments represent a modular class of prokaryotic organelles associated with metabolic processes. They harbor a congregation of enzymes that work in cascade within a small, confined volume. These sophisticated nano-engineered crafts of nature offer a tempting paradigm for the fabrication of biosynthetic nanoreactors. Repurposing bacterial microcompartments to develop nanostructures with desired functions requires a careful manipulation in their structural makeup and composition. This calls for a compr...
Source: Current Opinion in Microbiology - June 24, 2021 Category: Microbiology Authors: Gaurav Kumar Sharmistha Sinha Source Type: research

Biophysical approaches to understand and re-purpose bacterial microcompartments
Curr Opin Microbiol. 2021 Jun 21;63:43-51. doi: 10.1016/j.mib.2021.05.008. Online ahead of print.ABSTRACTBacterial microcompartments represent a modular class of prokaryotic organelles associated with metabolic processes. They harbor a congregation of enzymes that work in cascade within a small, confined volume. These sophisticated nano-engineered crafts of nature offer a tempting paradigm for the fabrication of biosynthetic nanoreactors. Repurposing bacterial microcompartments to develop nanostructures with desired functions requires a careful manipulation in their structural makeup and composition. This calls for a compr...
Source: Current Opinion in Microbiology - June 24, 2021 Category: Microbiology Authors: Gaurav Kumar Sharmistha Sinha Source Type: research

Bacterial microcompartments: tiny organelles with big potential
Curr Opin Microbiol. 2021 Jun 11;63:36-42. doi: 10.1016/j.mib.2021.05.010. Online ahead of print.ABSTRACTOrganization of metabolic processes within the space of a cell is critical for the survival of many organisms. In bacteria, spatial organization is achieved via proteinaceous organelles called bacterial microcompartments, which encapsulate pathway enzymes, substrates, and co-factors to drive the safe and efficient metabolism of niche carbon sources. Microcompartments are self-assembled from shell proteins that encapsulate a core comprising various enzymes. This review discusses how recent advances in understanding micro...
Source: Current Opinion in Microbiology - June 14, 2021 Category: Microbiology Authors: Nolan W Kennedy Carolyn E Mills Taylor M Nichols Charlotte H Abrahamson Danielle Tullman-Ercek Source Type: research

Bacterial microcompartments: tiny organelles with big potential
Curr Opin Microbiol. 2021 Jun 11;63:36-42. doi: 10.1016/j.mib.2021.05.010. Online ahead of print.ABSTRACTOrganization of metabolic processes within the space of a cell is critical for the survival of many organisms. In bacteria, spatial organization is achieved via proteinaceous organelles called bacterial microcompartments, which encapsulate pathway enzymes, substrates, and co-factors to drive the safe and efficient metabolism of niche carbon sources. Microcompartments are self-assembled from shell proteins that encapsulate a core comprising various enzymes. This review discusses how recent advances in understanding micro...
Source: Current Opinion in Microbiology - June 14, 2021 Category: Microbiology Authors: Nolan W Kennedy Carolyn E Mills Taylor M Nichols Charlotte H Abrahamson Danielle Tullman-Ercek Source Type: research

Bacterial microcompartments: tiny organelles with big potential
Curr Opin Microbiol. 2021 Jun 11;63:36-42. doi: 10.1016/j.mib.2021.05.010. Online ahead of print.ABSTRACTOrganization of metabolic processes within the space of a cell is critical for the survival of many organisms. In bacteria, spatial organization is achieved via proteinaceous organelles called bacterial microcompartments, which encapsulate pathway enzymes, substrates, and co-factors to drive the safe and efficient metabolism of niche carbon sources. Microcompartments are self-assembled from shell proteins that encapsulate a core comprising various enzymes. This review discusses how recent advances in understanding micro...
Source: Current Opinion in Microbiology - June 14, 2021 Category: Microbiology Authors: Nolan W Kennedy Carolyn E Mills Taylor M Nichols Charlotte H Abrahamson Danielle Tullman-Ercek Source Type: research

Bacterial microcompartments: tiny organelles with big potential
Curr Opin Microbiol. 2021 Jun 11;63:36-42. doi: 10.1016/j.mib.2021.05.010. Online ahead of print.ABSTRACTOrganization of metabolic processes within the space of a cell is critical for the survival of many organisms. In bacteria, spatial organization is achieved via proteinaceous organelles called bacterial microcompartments, which encapsulate pathway enzymes, substrates, and co-factors to drive the safe and efficient metabolism of niche carbon sources. Microcompartments are self-assembled from shell proteins that encapsulate a core comprising various enzymes. This review discusses how recent advances in understanding micro...
Source: Current Opinion in Microbiology - June 14, 2021 Category: Microbiology Authors: Nolan W Kennedy Carolyn E Mills Taylor M Nichols Charlotte H Abrahamson Danielle Tullman-Ercek Source Type: research

Bacterial microcompartments: tiny organelles with big potential
Curr Opin Microbiol. 2021 Jun 11;63:36-42. doi: 10.1016/j.mib.2021.05.010. Online ahead of print.ABSTRACTOrganization of metabolic processes within the space of a cell is critical for the survival of many organisms. In bacteria, spatial organization is achieved via proteinaceous organelles called bacterial microcompartments, which encapsulate pathway enzymes, substrates, and co-factors to drive the safe and efficient metabolism of niche carbon sources. Microcompartments are self-assembled from shell proteins that encapsulate a core comprising various enzymes. This review discusses how recent advances in understanding micro...
Source: Current Opinion in Microbiology - June 14, 2021 Category: Microbiology Authors: Nolan W Kennedy Carolyn E Mills Taylor M Nichols Charlotte H Abrahamson Danielle Tullman-Ercek Source Type: research

Bacterial microcompartments: tiny organelles with big potential
Curr Opin Microbiol. 2021 Jun 11;63:36-42. doi: 10.1016/j.mib.2021.05.010. Online ahead of print.ABSTRACTOrganization of metabolic processes within the space of a cell is critical for the survival of many organisms. In bacteria, spatial organization is achieved via proteinaceous organelles called bacterial microcompartments, which encapsulate pathway enzymes, substrates, and co-factors to drive the safe and efficient metabolism of niche carbon sources. Microcompartments are self-assembled from shell proteins that encapsulate a core comprising various enzymes. This review discusses how recent advances in understanding micro...
Source: Current Opinion in Microbiology - June 14, 2021 Category: Microbiology Authors: Nolan W Kennedy Carolyn E Mills Taylor M Nichols Charlotte H Abrahamson Danielle Tullman-Ercek Source Type: research

Bacterial microcompartments: tiny organelles with big potential
Curr Opin Microbiol. 2021 Jun 11;63:36-42. doi: 10.1016/j.mib.2021.05.010. Online ahead of print.ABSTRACTOrganization of metabolic processes within the space of a cell is critical for the survival of many organisms. In bacteria, spatial organization is achieved via proteinaceous organelles called bacterial microcompartments, which encapsulate pathway enzymes, substrates, and co-factors to drive the safe and efficient metabolism of niche carbon sources. Microcompartments are self-assembled from shell proteins that encapsulate a core comprising various enzymes. This review discusses how recent advances in understanding micro...
Source: Current Opinion in Microbiology - June 14, 2021 Category: Microbiology Authors: Nolan W Kennedy Carolyn E Mills Taylor M Nichols Charlotte H Abrahamson Danielle Tullman-Ercek Source Type: research

Bacterial microcompartments: tiny organelles with big potential
Curr Opin Microbiol. 2021 Jun 11;63:36-42. doi: 10.1016/j.mib.2021.05.010. Online ahead of print.ABSTRACTOrganization of metabolic processes within the space of a cell is critical for the survival of many organisms. In bacteria, spatial organization is achieved via proteinaceous organelles called bacterial microcompartments, which encapsulate pathway enzymes, substrates, and co-factors to drive the safe and efficient metabolism of niche carbon sources. Microcompartments are self-assembled from shell proteins that encapsulate a core comprising various enzymes. This review discusses how recent advances in understanding micro...
Source: Current Opinion in Microbiology - June 14, 2021 Category: Microbiology Authors: Nolan W Kennedy Carolyn E Mills Taylor M Nichols Charlotte H Abrahamson Danielle Tullman-Ercek Source Type: research

The microbial and host factors that govern Candida gastrointestinal colonization and dissemination
Curr Opin Microbiol. 2021 Jun 7;63:29-35. doi: 10.1016/j.mib.2021.05.012. Online ahead of print.ABSTRACTCandida species are among the most prevalent and abundant members of the gut mycobiota, with Candida albicans (CA) being the most prominent member. CA colonizes numerous mucosal surfaces, most notably the gastrointestinal (GI) and genitourinary tracts. In a healthy host, CA is a pathobiont that exists as a commensal but can become pathogenic if the host's immune system becomes suppressed. The microbial and/or host factors that dictate CA's ability to colonize mucosal surfaces and its ability to disseminate remain of grea...
Source: Current Opinion in Microbiology - June 10, 2021 Category: Microbiology Authors: Animesh Anand Mishra Andrew Y Koh Source Type: research

The microbial and host factors that govern Candida gastrointestinal colonization and dissemination
Curr Opin Microbiol. 2021 Jun 7;63:29-35. doi: 10.1016/j.mib.2021.05.012. Online ahead of print.ABSTRACTCandida species are among the most prevalent and abundant members of the gut mycobiota, with Candida albicans (CA) being the most prominent member. CA colonizes numerous mucosal surfaces, most notably the gastrointestinal (GI) and genitourinary tracts. In a healthy host, CA is a pathobiont that exists as a commensal but can become pathogenic if the host's immune system becomes suppressed. The microbial and/or host factors that dictate CA's ability to colonize mucosal surfaces and its ability to disseminate remain of grea...
Source: Current Opinion in Microbiology - June 10, 2021 Category: Microbiology Authors: Animesh Anand Mishra Andrew Y Koh Source Type: research

The microbial and host factors that govern Candida gastrointestinal colonization and dissemination
Curr Opin Microbiol. 2021 Jun 7;63:29-35. doi: 10.1016/j.mib.2021.05.012. Online ahead of print.ABSTRACTCandida species are among the most prevalent and abundant members of the gut mycobiota, with Candida albicans (CA) being the most prominent member. CA colonizes numerous mucosal surfaces, most notably the gastrointestinal (GI) and genitourinary tracts. In a healthy host, CA is a pathobiont that exists as a commensal but can become pathogenic if the host's immune system becomes suppressed. The microbial and/or host factors that dictate CA's ability to colonize mucosal surfaces and its ability to disseminate remain of grea...
Source: Current Opinion in Microbiology - June 10, 2021 Category: Microbiology Authors: Animesh Anand Mishra Andrew Y Koh Source Type: research

The microbial and host factors that govern Candida gastrointestinal colonization and dissemination
Curr Opin Microbiol. 2021 Jun 7;63:29-35. doi: 10.1016/j.mib.2021.05.012. Online ahead of print.ABSTRACTCandida species are among the most prevalent and abundant members of the gut mycobiota, with Candida albicans (CA) being the most prominent member. CA colonizes numerous mucosal surfaces, most notably the gastrointestinal (GI) and genitourinary tracts. In a healthy host, CA is a pathobiont that exists as a commensal but can become pathogenic if the host's immune system becomes suppressed. The microbial and/or host factors that dictate CA's ability to colonize mucosal surfaces and its ability to disseminate remain of grea...
Source: Current Opinion in Microbiology - June 10, 2021 Category: Microbiology Authors: Animesh Anand Mishra Andrew Y Koh Source Type: research

Bacterial microcompartments and their role in pathogenicity
Curr Opin Microbiol. 2021 Jun 6;63:19-28. doi: 10.1016/j.mib.2021.05.009. Online ahead of print.ABSTRACTCatabolic bacterial microcompartments (BMC), or metabolosomes, are self-assembling structures formed by enzymes enclosed by porous protein shells. They provide a specialised environment inside bacterial cells separating a short catabolic pathway with reactive or toxic intermediates from the cytoplasm. Substrates for microcompartment metabolism like ethanolamine and 1,2-propanediol are constantly produced in the human intestine by bacterial metabolism of food or host cell components. Enteric pathogens gain a competitive a...
Source: Current Opinion in Microbiology - June 9, 2021 Category: Microbiology Authors: Michael B Prentice Source Type: research

Bacterial microcompartments and their role in pathogenicity
Curr Opin Microbiol. 2021 Jun 6;63:19-28. doi: 10.1016/j.mib.2021.05.009. Online ahead of print.ABSTRACTCatabolic bacterial microcompartments (BMC), or metabolosomes, are self-assembling structures formed by enzymes enclosed by porous protein shells. They provide a specialised environment inside bacterial cells separating a short catabolic pathway with reactive or toxic intermediates from the cytoplasm. Substrates for microcompartment metabolism like ethanolamine and 1,2-propanediol are constantly produced in the human intestine by bacterial metabolism of food or host cell components. Enteric pathogens gain a competitive a...
Source: Current Opinion in Microbiology - June 9, 2021 Category: Microbiology Authors: Michael B Prentice Source Type: research

Mycoviruses and their role in fungal pathogenesis
Curr Opin Microbiol. 2021 Jun 5;63:10-18. doi: 10.1016/j.mib.2021.05.007. Online ahead of print.ABSTRACTNowadays, the focus of mycovirology research has expanded from plant pathogenic fungi and mycovirus mediated hypovirulence to include insect and human pathogenic fungi together with a range of mycovirus mediated phenotypes, such as hypervirulence, control of endophytic traits, regulation of metabolite production and drug resistance. In fungus-mycovirus-environmental interactions, the environment and both abiotic and biotic factors play crucial roles in whether and how mycovirus mediated phenotypes are manifest. Mycovirus...
Source: Current Opinion in Microbiology - June 8, 2021 Category: Microbiology Authors: Ioly Kotta-Loizou Source Type: research

Evolutionary relationships among shell proteins of carboxysomes and metabolosomes
Curr Opin Microbiol. 2021 Jun 4;63:1-9. doi: 10.1016/j.mib.2021.05.011. Online ahead of print.ABSTRACTBacterial microcompartments (BMCs) are self-assembling prokaryotic organelles which encapsulate enzymes within a polyhedral protein shell. The shells are comprised of only two structural modules, distinct domains that form pentagonal and hexagonal building blocks, which occupy the vertices and facets, respectively. As all BMC loci encode at least one hexamer-forming and one pentamer-forming protein, the evolutionary history of BMCs can be interrogated from the perspective of their shells. Here, we discuss how structures of...
Source: Current Opinion in Microbiology - June 7, 2021 Category: Microbiology Authors: Matthew R Melnicki Markus Sutter Cheryl A Kerfeld Source Type: research

Quantitative analysis of horizontal gene transfer in complex systems
Curr Opin Microbiol. 2021 Jun 4;62:103-109. doi: 10.1016/j.mib.2021.05.001. Online ahead of print.ABSTRACTHorizontal gene transfer (HGT) plays a significant role in rapidly propagating diverse traits throughout bacterial populations, thereby accelerating natural evolution and leading to complex community structures. Critical gene transfer rates underlying these occurrences dictate the efficiency and speed of gene spread; these rates are often highly specific to HGT mechanism and environmental context, and have historically been challenging to reliably quantify. In this review, we examine recent works that leverage rigorous...
Source: Current Opinion in Microbiology - June 7, 2021 Category: Microbiology Authors: Jenifer Moralez Karolina Szenkiel Kerry Hamilton Amy Pruden Allison J Lopatkin Source Type: research

Heterothermy and antifungal responses in bats
Curr Opin Microbiol. 2021 Jun 4;62:61-67. doi: 10.1016/j.mib.2021.05.002. Online ahead of print.ABSTRACTHibernation, a period where bats have suppressed immunity and low body temperatures, provides the psychrophilic fungus Pseudogymnoascus destructans the opportunity to colonise bat skin, leading to severe disease in susceptible species. Innate immunity, which requires less energy and may remain more active during torpor, can control infections with local inflammation in some bat species that are resistant to infection. If infection is not controlled before emergence from hibernation, ineffective adaptive immune mechanisms...
Source: Current Opinion in Microbiology - June 7, 2021 Category: Microbiology Authors: Flora Whiting-Fawcett Kenneth A Field S ébastien J Puechmaille Anna S Blomberg Thomas M Lilley Source Type: research

Towards a deeper understanding of microbial communities: integrating experimental data with dynamic models
Curr Opin Microbiol. 2021 Jun 4;62:84-92. doi: 10.1016/j.mib.2021.05.003. Online ahead of print.ABSTRACTMicrobial communities and their functions are shaped by complex networks of interactions among microbes and with their environment. While the critical roles microbial communities play in numerous environments have become increasingly appreciated, we have a very limited understanding of their interactions and how these interactions combine to generate community-level behaviors. This knowledge gap hinders our ability to predict community responses to perturbations and to design interventions that manipulate these communiti...
Source: Current Opinion in Microbiology - June 7, 2021 Category: Microbiology Authors: Yili Qian Freeman Lan Ophelia S Venturelli Source Type: research

Cutaneous and subcutaneous fungal infections: recent developments on host-fungus interactions
Curr Opin Microbiol. 2021 Jun 4;62:93-102. doi: 10.1016/j.mib.2021.05.005. Online ahead of print.ABSTRACTThe incidence of skin fungal infections is increasing at an alarming rate worldwide, presenting a major challenge to health professionals. Cutaneous and subcutaneous fungal infections are caused by pathogenic or opportunistic organisms varying from mold, yeasts, to dimorphic fungi. Recently, skin fungal have been increasingly reported and studied, giving rise to crucial breakthroughs in etiology and pathogenesis. This review aims to summarize recent insights into the clinical and etiological characteristics of common sk...
Source: Current Opinion in Microbiology - June 7, 2021 Category: Microbiology Authors: Yubo Ma Xiaowen Wang Ruoyu Li Source Type: research

Evolutionary relationships among shell proteins of carboxysomes and metabolosomes
Curr Opin Microbiol. 2021 Jun 4;63:1-9. doi: 10.1016/j.mib.2021.05.011. Online ahead of print.ABSTRACTBacterial microcompartments (BMCs) are self-assembling prokaryotic organelles which encapsulate enzymes within a polyhedral protein shell. The shells are comprised of only two structural modules, distinct domains that form pentagonal and hexagonal building blocks, which occupy the vertices and facets, respectively. As all BMC loci encode at least one hexamer-forming and one pentamer-forming protein, the evolutionary history of BMCs can be interrogated from the perspective of their shells. Here, we discuss how structures of...
Source: Current Opinion in Microbiology - June 7, 2021 Category: Microbiology Authors: Matthew R Melnicki Markus Sutter Cheryl A Kerfeld Source Type: research

Quantitative analysis of horizontal gene transfer in complex systems
Curr Opin Microbiol. 2021 Jun 4;62:103-109. doi: 10.1016/j.mib.2021.05.001. Online ahead of print.ABSTRACTHorizontal gene transfer (HGT) plays a significant role in rapidly propagating diverse traits throughout bacterial populations, thereby accelerating natural evolution and leading to complex community structures. Critical gene transfer rates underlying these occurrences dictate the efficiency and speed of gene spread; these rates are often highly specific to HGT mechanism and environmental context, and have historically been challenging to reliably quantify. In this review, we examine recent works that leverage rigorous...
Source: Current Opinion in Microbiology - June 7, 2021 Category: Microbiology Authors: Jenifer Moralez Karolina Szenkiel Kerry Hamilton Amy Pruden Allison J Lopatkin Source Type: research