The Transcriptome of the Salivary Glands of Amblyomma aureolatum Reveals the Antimicrobial Peptide Microplusin as an Important Factor for the Tick Protection Against Rickettsia rickettsii Infection

The Transcriptome of the Salivary Glands of Amblyomma aureolatum Reveals the Antimicrobial Peptide Microplusin as an Important Factor for the Tick Protection Against Rickettsia rickettsii Infection Larissa A. Martins1, Camila D. Malossi1†, Maria F. B. de M. Galletti1†, José M. Ribeiro2, André Fujita3, Eliane Esteves4, Francisco B. Costa5, Marcelo B. Labruna5, Sirlei Daffre1 and Andréa C. Fogaça1* 1Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil 2Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD, United States 3Departamento de Ciência da Computação, Instituto de Matemática e Estatística, Universidade de São Paulo, São Paulo, Brazil 4Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil 5Departamento de Medicina Veterinária Preventiva e Saúde Animal, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, Brazil The salivary glands (SG) of ixodid ticks play a pivotal role in blood feeding, producing both the cement and the saliva. The cement is an adhesive substance that helps the attachment of the tick to the host skin, while the saliva contains a rich mixture of antihemostatic, anti-inf...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

Related Links:

This report describes a new lethal case of Rickettsia rickettsii infection in a child from Northwestern Colombia, after ten years of the last outbreaks in the same region. Colombian public-health authorities should consider to include this severe rickettsiosis in the compulsory-reporting diseases, with the aim of knowing its burden in the country.
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
In conclusion, these results indicate that AtlASS autolysin modulates bacterial chain length, and contributes to the full virulence of SS during infection.
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Conclusion:   CoBaT-Y017 presented a significant safety and tolerability in healthy volunteers to allow its further development by starting a phase II clinical study. PMID: 31118966 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Authors: Oei SL, Thronicke A, Schad F Abstract In early tumor development, cancer cells develop a plethora of strategies to escape surveillance from the adaptive and innate immune system. Cancer immunotherapies, in particular immune checkpoint inhibitors, are becoming a highly promising cancer therapeutic approach that has remarkable increased progress in combating various cancer types. Unfortunately, their mechanisms of action induce some complications, such as inflammatory reactions and immune-related adverse events. In the management of side effects during anticancer therapy, complementary and integrative therap...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
In this study, we report that the Protium javanicum methanol extract (Pj-ME) plays an important role in suppressing nitric oxide (NO) levels without cytotoxicity. The effect of Pj-ME in LPS-induced expression leads to reduced inflammatory cytokine expression, specifically inducible nitric oxide synthase (iNOS), cyclooxygenase (COX-2), and tumor necrosis factor (TNF-α). Pj-ME significantly inhibited LPS-induced protein expression of the nuclear factor-kappa B (NF-κB) signaling pathway in a time-dependent manner. Syk and Src were identified as putative signaling molecules of Pj-ME-mediated anti-inflammatory activ...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Publication date: Available online 24 May 2019Source: Molecular Phylogenetics and EvolutionAuthor(s): Bruno S. Amorim, Thais N.C. Vasconcelos, Gustavo Souza, Marccus Alves, Alexandre Antonelli, Eve LucasAbstractMyrcia is the largest exclusively Neotropical genus of the plant family Myrtaceae with c. 770 species. Although several studies have elucidated the relationships within particular sections of the genus, to date no phylogeny has been produced that includes a broad taxonomic and geographic representation. Here we present a phylogenetic hypothesis of Myrcia and close relatives comprising 253 species and based on two nu...
Source: Molecular Phylogenetics and Evolution - Category: Molecular Biology Source Type: research
Publication date: Available online 24 May 2019Source: MethodsAuthor(s): Heinz Steffens, Waja Wegner, Katrin I. WilligAbstractSuperresolution microscopy techniques are now widely used, but their application in living animals remains a challenging task. The first superresolution imaging in a live vertebrate was demonstrated with STED microscopy in the visual cortex of an anaesthetized mouse. Here, we explain the requirements for a simple but robust in vivo STED microscope as well as the surgical preparation of the cranial window and the mounting of the mouse in detail. We have developed a mounting stage with a heating plate ...
Source: Methods - Category: Molecular Biology Source Type: research
Publication date: Available online 25 May 2019Source: Journal of Molecular StructureAuthor(s): Sirem Kiraz, Duygu İnci, Rahmiye Aydın, Özgür Vatan, Yunus Zorlu, Tolga CavaşAbstractNew water soluble copper(II) complexes, - [Cu(phen)(gln)(H2O)]NO3·H2O (1) and [Cu(dmphen)(gln)(H2O)]ClO4 (2) - (phen: 1,10-phenanthroline, dmphen: 4,7-dimethyl-1,10-phenanthroline, gln: l-glutamine), have been synthesized and characterized by CHN analysis, ATR-FT-MIR, ESI-MS and single-crystal X-ray diffraction techniques. Binary and ternary complexes of copper(II) with the selected ligands have been investigated using potenti...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01086F, CommunicationTanveer Ahmad, Qi Li, Sheng-Qi Qiu, Jian-Lin Xu, Yun-He Xu, Teck-Peng Loh A copper-catalyzed regioselective 1,4- and 1,6-conjugate addition of silyl reagent to the diendioates was established. Various 1,4- and 1,6-protosilylation products were obtained in good yields and with high regioselectivity via... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
This study is focused on the diversity of fungal species colonising washing machines, and investigates the possible relationship between the habits of washing machine users and the colonising species. Housekeeping conditions and habits of washing machine users were assessed in Hungary with a questionnaire. After sampling, several different fungal species were identified by microscopy and sequence analysis of diagnostic loci. Based on the results, 32% of the sampled washing machines were highly polluted with various species of fungi. Forty six percent of the observed devices were colonised also by opportunistically human pa...
Source: Fungal Biology - Category: Biology Source Type: research
More News: Academia | Allergy | Allergy & Immunology | Anaplasmosis | Anesthesia | Anesthesiology | Babesiosis | Biochemistry | Biology | Brain | Brazil Health | Candida | Copper | Databases & Libraries | Dengue Fever | Dermatology | Education | Genetics | Germany Health | Grants | Headache | Honey | Hormones | Infectious Diseases | Lyme Disease | Malaria | Medical Ethics | Men | Microbiology | Migraine | Molecular Biology | Nanotechnology | Neurology | Nutrition | Ovaries | Oxford University | Pakistan Health | Parasitology | Physiology | Reproduction Medicine | Science | Skin | Skin Biopsy | Slovakia Health | Statistics | Students | Study | Switzerland Health | Tickborne Diseases | Universities & Medical Training | Urology & Nephrology | USA Health | Vasculitis | Veterinary Research | Websites | Zoonoses