The Transcriptome of the Salivary Glands of Amblyomma aureolatum Reveals the Antimicrobial Peptide Microplusin as an Important Factor for the Tick Protection Against Rickettsia rickettsii Infection

The Transcriptome of the Salivary Glands of Amblyomma aureolatum Reveals the Antimicrobial Peptide Microplusin as an Important Factor for the Tick Protection Against Rickettsia rickettsii Infection Larissa A. Martins1, Camila D. Malossi1†, Maria F. B. de M. Galletti1†, José M. Ribeiro2, André Fujita3, Eliane Esteves4, Francisco B. Costa5, Marcelo B. Labruna5, Sirlei Daffre1 and Andréa C. Fogaça1* 1Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil 2Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD, United States 3Departamento de Ciência da Computação, Instituto de Matemática e Estatística, Universidade de São Paulo, São Paulo, Brazil 4Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil 5Departamento de Medicina Veterinária Preventiva e Saúde Animal, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, Brazil The salivary glands (SG) of ixodid ticks play a pivotal role in blood feeding, producing both the cement and the saliva. The cement is an adhesive substance that helps the attachment of the tick to the host skin, while the saliva contains a rich mixture of antihemostatic, anti-inf...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

Related Links:

Publication date: Available online 15 February 2020Source: Trends in Anaesthesia and Critical CareAuthor(s): Ulrich Braun, Karl Günther Wiese, Hans-Albert Merten, Arnd TimmermannAbstractNoma (Cancrum oris) is an infectious acute disease that is prevalent in Africa, Asia and the American continent. This condition develops as a consequence of deficient nutrition. It is acquired by children between the ages of 1 and 7, and the children who contract it can die from sepsis within 2 weeks. The estimated mortality rate is in the range of 85%. The survivors have disfigurements of the face, massive scarring, open access to the...
Source: Trends in Anaesthesia and Critical Care - Category: Anesthesiology Source Type: research
Publication date: Available online 15 February 2020Source: Trends in Anaesthesia and Critical CareAuthor(s): Sima Patel, Andrea Estevez, Nicholas Nedeff, Jose Gascon, Ilde LeeAbstractAcross the United States (U.S.), very few centers exist with an intensive care unit (ICU) solely dedicated to obstetrics (OB) and gynecology (GYN) patients. The management of obstetric patients, who are admitted to a general intensive care unit, can often be accompanied by a fair share of apprehension owing to the intricacy of care. Rather than discussing common obstetric emergencies and their management, we would like to call attention to bas...
Source: Trends in Anaesthesia and Critical Care - Category: Anesthesiology Source Type: research
Authors: Meyer D, Smit DP Abstract Both infective and neoplastic eyelid and orbital conditions in human immunodeficiency virus (HIV) infected patients are often the result of opportunistic or co-infections (OI). In most cases, these clinical findings in younger patients alert the physician to suspected underlying HIV infection. When the eyelids and periorbital skin are primarily involved in OI with varicella-zoster virus it is called Herpes Zoster Ophthalmicus. Co-infection with a Pox virus manifests as molluscum contagiosum eruptions. Orbital cellulitis is secondary to various organisms (Mycobacterium tuberculosis...
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Abstract Recent large-scale community sequencing efforts allow at an unprecedented level of detail the identification of genomic regions that show signatures of natural selection. Traditional methods for identifying such regions from individuals' haplotype data, however, require excessive computing times and therefore are not applicable to current datasets. In 2019, Cunha et al. (Advances in bioinformatics and computational biology: 11th Brazilian symposium on bioinformatics, BSB 2018, Niterói, Brazil, October 30 - November 1, 2018, Proceedings, 2018. 10.1007/978-3-030-01722-4_3) suggested the maximal perfe...
Source: Algorithms for Molecular Biology : AMB - Category: Molecular Biology Authors: Tags: Algorithms Mol Biol Source Type: research
Publication date: Available online 15 February 2020Source: Materials Today: ProceedingsAuthor(s): Svetlana Shasherina, Margarita Skotnikova, Alexander SokolovAbstractSurface machining attrition treatment (SMAT) was performed on a copper–nickel covering of tool steel H12MF to form a nanostructured (NS) layer on the surface of the sample. Tribotechnical, metallographic, physical and chemical properties of nanostructured nickel–copper coverings were investigated. The results of tribological tests showed that after applying the Ni–Cu covering, the relative wear resistance of H12MF steel significantly increase...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Publication date: Available online 15 February 2020Source: Materials Today: ProceedingsAuthor(s): Gajanan M. Naik, B. Sachin, Ravindra I. Badiger, Ajit M. HebbaleAbstractThe mechanical and physical properties that are achieved with Zn-Al metal matrix composites (MMCs) have made them popular candidate materials for automotive, aerospace and several other applications. In recent years, Zn-Al alloys are used as bearing and bushing materials as a substitute for copper based and aluminium based bearing materials due to their relatively low costs and superior tribological characteristics. Additions of hard ceramic particulates l...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Publication date: Available online 15 February 2020Source: Materials Science and Engineering: AAuthor(s): C.X. Ren, Q. Wang, J.P. Hou, Z.J. Zhang, H.J. Yang, Z.F. ZhangAbstractSurface strengthened Cu samples with ultra-fine grain (UFG), fine grain (FG), and coarse grain (CG) matrixes were prepared by cold-rolling, controlled annealing, and then treated by surface spinning strengthening (3S) to reveal the effect of grain size on the feature of the hardened layer. The results indicate that the maximum microhardness of the hardened layer was slightly affected by grain size. The thickness of the hardened layer is significantly...
Source: Materials Science and Engineering: A - Category: Materials Science Source Type: research
Authors: Augstburger E, Héron E, Abanou A, Habas C, Baudouin C, Labbe A Abstract Ischemic optic neuropathies are among the leading causes of severe visual acuity loss in people over 50 years of age. They constitute a set of various entities that are clinically, etiologically and therapeutically different. Anatomically, it is necessary to distinguish anterior and posterior forms. From an etiological point of view, the diagnosis of the arteritic form due to giant cell arteritis requires emergent management to prevent blindness and even death in the absence of prompt corticosteroid treatment. When this diagnosi...
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Authors: Burris M, Miller E, Romero-Daza N, Himmelgreen D Abstract The aim of this study was to assess whether household food insecurity is associated with delayed or early menarche among girls in the United States. Thirty-six dyadic household interviews were conducted with mothers and adolescent girls. The interviews included a socio-demographic survey, the USDA Six-Item Short Form Household Food Security Survey Module, anthropometric measurements, and the self-administered Youth-Adolescent Food Frequency Questionnaire. Using non-parametric quantitative analyses, we examined the associations among food insecurity,...
Source: Ecology of Food and Nutrition - Category: Nutrition Tags: Ecol Food Nutr Source Type: research
This study examined age differences in associations among primary stressors (caregiver burden which includes hours of provided care and number of activities of daily living and instrumental activities of daily living performed), secondary stressors (financial and employment strains), and caregiver outcomes (emotional strain and physical strain). RESEARCH DESIGN: Using Pearlin's Stress Process Model (1990) and the Caregiving in the United States 2015 dataset, 1,156 caregivers were identified (including 278 young adults aged 18-39 years, 464 midlife adults aged 40-59 years, and 414 older adults aged 60-80 years). RES...
Source: International Journal of Aging and Human Development - Category: Geriatrics Tags: Int J Aging Hum Dev Source Type: research
More News: Academia | Allergy | Allergy & Immunology | Anaplasmosis | Anesthesia | Anesthesiology | Babesiosis | Biochemistry | Biology | Brain | Brazil Health | Candida | Copper | Databases & Libraries | Dengue Fever | Dermatology | Education | Genetics | Germany Health | Grants | Headache | Honey | Hormones | Infectious Diseases | Lyme Disease | Malaria | Medical Ethics | Men | Microbiology | Migraine | Molecular Biology | Nanotechnology | Neurology | Nutrition | Ovaries | Oxford University | Pakistan Health | Parasitology | Physiology | Reproduction Medicine | Science | Skin | Skin Biopsy | Slovakia Health | Statistics | Students | Study | Switzerland Health | Tickborne Diseases | Universities & Medical Training | Urology & Nephrology | USA Health | Vasculitis | Veterinary Research | Websites | Zoonoses