Oligonucleotide Microarrays Identified Potential Regulatory Genes Related to Early Outward Arterial Remodeling Induced by Tissue Plasminogen Activator

Oligonucleotide Microarrays Identified Potential Regulatory Genes Related to Early Outward Arterial Remodeling Induced by Tissue Plasminogen Activator Olga Plekhanova1,2*, Yelena Parfyonova1,2, Irina Beloglazova1,2, Bradford C. Berk3 and Vsevolod Tkachuk1,2 1Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia 2National Medical Research Center of Cardiology, Moscow, Russia 3Aab Cardiovascular Research Institute, University of Rochester Medical Center, Rochester, NY, United States Constrictive vascular remodeling limiting blood flow, as well as compensatory outward remodeling, has been observed in many cardiovascular diseases; however, the underlying mechanisms regulating the remodeling response of the vessels remain unclear. Plasminogen activators (PA) are involved in many of the processes of vascular remodeling. We have shown previously that increased levels of tissue-type PA (tPA) contributes to outward vascular remodeling. To elucidate the mechanisms involved in the induction of outward remodeling we characterized changes in the expression profiles of 8799 genes in injured rat carotid arteries 1 and 4 days after recombinant tPA treatment compared to vehicle. Periadventitial tPA significantly increased lumen size and vessel area, encompassed by the external elastic lamina, at both one and 4 days after treatment. Among 41 differentially expressed known genes 1 day after tPA application, five genes were involved in gene transcription, five genes w...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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Source: European Urology - Category: Urology & Nephrology Source Type: research
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