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Recalled in US: Three Lots of Alteplase (Activase), Vial Leakage Hazard Recalled in US: Three Lots of Alteplase (Activase), Vial Leakage Hazard
Genentech says the thrombolytic agent in 100 mg vials was copackaged with sterile water for injection; the water vials may be"cracked or chipped" and no longer sterile.News Alerts (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 7, 2017 Category: Consumer Health News Tags: Cardiology News Alert Source Type: news

Genentech Issues Voluntary Nationwide Recall of Three Lots of Activase & reg; (Alteplase)-100 mg Due to Lack of Sterility Assurance of the Sterile Water for Injection
Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), is voluntarily recalling three lots of Activase ® (alteplase) 100mg vials, that were co-packaged with Sterile Water for Injection, to the hospital level. The vials of Sterile Water for Injection, manufactured by Hospira Inc., a Pfizer company, and packaged with Activase 100 mg, may be cracked or chipped at the neck of the vial and leaking. (Source: Food and Drug Administration)
Source: Food and Drug Administration - September 7, 2017 Category: Food Science Source Type: news

Tenecteplase Not Better or Safer in Ischemic Stroke
(MedPage Today) -- First head-to-head trial shows no advantage against alteplase (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - August 3, 2017 Category: American Health Source Type: news

Cathflo Activase (Alteplase Powder for Reconstitution for Use in Central Venous Access Devices) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - July 12, 2017 Category: Drugs & Pharmacology Source Type: news

Memphis Mobile Stroke Unit Saves Lives
A year after a mobile stroke unit hit the streets of Memphis, officials say it is saving lives by cutting the time it takes to treat stroke patients. The University of Tennessee Health Science Center began using the 14-ton ambulance last year as part of a three-year controlled study. The unit has a CT scanner that can X-ray images of the brain, and is equipped to provide early fluids to stroke patients and dye blood vessels to determine the type of stroke the patient has had. "The emergency room on average takes 40 to 50 minutes to do the things we do in 13 to 14 minutes," said Dr.Andrei Alexandrov, UTHSC neurolo...
Source: JEMS: Journal of Emergency Medical Services News - June 10, 2017 Category: Emergency Medicine Authors: Olivia Peterkin, The Commercial Appeal Tags: News Mobile Integrated Healthcare Source Type: news

NOR-TEST: Tenecteplase Similar to Alteplase in Stroke NOR-TEST: Tenecteplase Similar to Alteplase in Stroke
The newer thrombolytic given as a bolus dose showed functional and safety outcomes similar to those of alteplase infusion in the NOR-TEST trial.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 19, 2017 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Lori’s Stroke Required Help From Doctors An Hour Away. Telemedicine Provided It.
Editor’s note: Our previous stories this American Stroke Month featured warning signs heeded and missed. Today we shift gears to showcase a textbook response to a stroke, including the crucial role of telestroke, a way for experts at another facility to help care for a patient via a webcam-type connection. The CHRONIC Care Act, which includes a provision to require Medicare to cover telestroke, will be discussed Tuesday during a hearing of the Senate Finance Committee. Lori Hoopingarner savored her occasional weekend getaway. Between running her financial advising company, raising a 10-year-old daughter and 6-year-o...
Source: Healthy Living - The Huffington Post - May 15, 2017 Category: Consumer Health News Source Type: news

MassDevice.com +5 | The top 5 medtech stories for February 24, 2017
Say hello to MassDevice +5, a bite-sized view of the top five medtech stories of the day. This feature of MassDevice.com’s coverage highlights our 5 biggest and most influential stories from the day’s news to make sure you’re up to date on the headlines that continue to shape the medical device industry. Get this in your inbox everyday by subscribing to our newsletters. 5. FDA panel supports Claret Medical’s Sentinel, despite efficacy questions The FDA’s Circulatory System Devices Panel this week gave its support to de novo clearance for Claret Medical’s Sentinel embolic protection dev...
Source: Mass Device - February 24, 2017 Category: Medical Equipment Authors: Brad Perriello Tags: News Well Plus 5 Source Type: news

Stroke Care: A Balanced Approach to the tPA Debate
In conclusion, alteplase is the only treatment available for acute ischemic stroke that is effective in some patients. In order to improve tPA effectiveness and minimize risks, patients with symptoms suggestive of an AIS should get rapid assessment and treatment with tPA after careful review of the contraindications. Given that smaller strokes can still be associated with considerable long term neurological morbidity, treatment should still be considered in those patients after weighing the risks and benefits and in consultation with the patient and family. Advanced age should also not be a limiting factor. Although the NI...
Source: EPMonthly.com - December 31, 2016 Category: Emergency Medicine Authors: Logan Plaster Tags: Uncategorized Source Type: news

alteplase (TPA, Activase, Cathflo Activase)
Title: alteplase (TPA, Activase, Cathflo Activase)Category: MedicationsCreated: 12/19/2000 12:00:00 AMLast Editorial Review: 11/3/2016 12:00:00 AM (Source: MedicineNet Heart General)
Source: MedicineNet Heart General - November 3, 2016 Category: Cardiology Source Type: news

A Paradigm Shift in EMS Evaluation Of Stroke
BackgroundMontgomery County Hospital District EMS (MCHD) is collaborating with the South East Texas Regional Advisory Committee (SETRAC) to validate their existing prehospital suspected neurological event guideline for stroke assessment and transport.MCHD is a non-fire based EMS service in Montgomery County, Texas. We respond to approximately 58,000 calls to service and identify stroke in more than 500 patients per year. Our EMS system covers an estimated 1,100-square-mile service area and has 190 medics, 900 EMTs and 15 first responder (FR) organizations.Acute ischemic stroke (AIS) is a debilitating and costly disease wit...
Source: JEMS Patient Care - August 12, 2016 Category: Emergency Medicine Authors: Robert L. Dickson, MD, FAAEM, FACEP, FACEM Tags: Patient Care Source Type: news

A Paradigm Shift in EMS Evaluation Of Stroke
Background Montgomery County Hospital District EMS (MCHD) is collaborating with the South East Texas Regional Advisory Committee (SETRAC) to validate their existing prehospital suspected neurological event guideline for stroke assessment and transport. MCHD is a non-fire based EMS service in Montgomery County, Texas. We respond to approximately 58,000 calls to service and identify stroke in more than 500 patients per year. Our EMS system covers an estimated 1,100-square-mile service area and has 190 medics, 900 EMTs and 15 first responder (FR) organizations. Acute ischemic stroke (AIS) is a debilitating and costly disease ...
Source: JEMS Patient Care - August 12, 2016 Category: Emergency Medicine Authors: Robert L. Dickson, MD, FAAEM, FACEP, FACEM Tags: Patient Care Source Type: news

Alteplase confers long-term survival benefit after stroke
Alteplase treatment in patients with acute ischaemic stroke is associated with a survival benefit among those who survive the acute phase, shows further analysis of IST-3. (Source: MedWire News)
Source: MedWire News - July 26, 2016 Category: Consumer Health News Tags: Stroke Source Type: news

MHRA review confirms benefit/risk profile of Alteplase - the only licensed clot buster for acute ischaemic stroke
(Source: Boehringer Ingelheim Corporate News)
Source: Boehringer Ingelheim Corporate News - July 25, 2016 Category: Research Source Type: news

NICE recommends treatment with alteplase is started as early as possible, within 4.5 hours of onset of ischaemic stroke symptoms
(Source: Boehringer Ingelheim Corporate News)
Source: Boehringer Ingelheim Corporate News - July 25, 2016 Category: Research Source Type: news

Activase (Alteplase) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - July 12, 2016 Category: Drugs & Pharmacology Source Type: news

alteplase (Activase, Cathflo Activase, TPA)
Title: alteplase (Activase, Cathflo Activase, TPA)Category: MedicationsCreated: 12/19/2000 12:00:00 AMLast Editorial Review: 5/31/2016 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - May 31, 2016 Category: Drugs & Pharmacology Source Type: news

Reducing doses of common stroke drug 'could save thousands of lives'
Reducing the dose of alteplase – taken by one in nine stroke patients – would slash brain bleeds by two thirds and death rates by a sixth, according to an international study led by Leicester University. (Source: the Mail online | Health)
Source: the Mail online | Health - May 11, 2016 Category: Consumer Health News Source Type: news

ENCHANTED results challenge reduced alteplase dose in Asian stroke patients
A reduced dose of alteplase has failed to prove itself noninferior to the standard dose in a predominantly Asian population of patients with ischaemic stroke. (Source: MedWire News)
Source: MedWire News - May 10, 2016 Category: Consumer Health News Tags: Stroke Source Type: news

Seeking an alteplase alternative for stroke
Where is a biosimilar when you need one? A few weeks ago, I reported on an advisory committee of the Food and Drug Administration overwhelmingly recommending that the agency approve a biosimilar... (Source: Family Practice News)
Source: Family Practice News - March 8, 2016 Category: Primary Care Source Type: news

Seeking an alteplase alternative for stroke
Where is a biosimilar when you need one? A few weeks ago, I reported on an advisory committee of the Food and Drug Administration overwhelmingly recommending that the agency approve a biosimilar... (Source: Clinical Neurology News)
Source: Clinical Neurology News - March 8, 2016 Category: Neurology Source Type: news

VIDEO: A better way to treat large intraventricular hemorrhages
LOS ANGELES – For intraventricular hemorrhages of at least 20 mL, alteplase (Activase – Genentech) delivered directly into the clot by external ventricular drain almost doubles the odds of achieving... (Source: Family Practice News)
Source: Family Practice News - February 29, 2016 Category: Primary Care Source Type: news

VIDEO: A better way to treat large intraventricular hemorrhages
LOS ANGELES – For intraventricular hemorrhages of at least 20 mL, alteplase (Activase – Genentech) delivered directly into the clot by external ventricular drain almost doubles the odds of achieving... (Source: Clinical Neurology News)
Source: Clinical Neurology News - February 29, 2016 Category: Neurology Source Type: news

Clot-busting drug improves survival for deadly form of stroke
Stephen FellerLOS ANGELES, Feb. 18 (UPI) -- Clot-busting drug Alteplase, used for heart attacks and non-bleeding strokes, can reduce disability and mortality in patients with a type of bleeding stroke. (Source: Health News - UPI.com)
Source: Health News - UPI.com - February 18, 2016 Category: Consumer Health News Source Type: news

Medtronic touts Solitaire stent retriever meta-analysis
The Solitare stent retriever Medtronic (NYSE:MDT) acquired for $50 billion last year when it bought Covidien is safe and highly effective when combined with standard care using the thrombolysis drug alteplase, according to a meta-analysis of 4 previous trials of the device. The transcatheter Solitaire device uses a stent-like device to trap and retrieve a blood clot in the brain in cases of ischemic stroke. Researchers from the 4 trials – Swift Prime, Revascat, Extend-IA and Escape – pooled their data to examine the results from 787 patients, randomized to either thrombectomy with the Solita...
Source: Mass Device - February 18, 2016 Category: Medical Equipment Authors: Brad Perriello Tags: Clinical Trials Neurological Vascular Medtronic Stroke Source Type: news

No extra benefit from task-orientated stroke rehabilitation programmes
Nor did increasing therapy time offer additional improvement in motor functionRelated items from OnMedicaLight therapy may improve stroke recoveryTime to rethink 4.5h window for alteplase after strokeStroke patients still not getting care they needStroke and other vascular disordersNHS stroke care getting better (Source: OnMedica Latest News)
Source: OnMedica Latest News - February 10, 2016 Category: UK Health Source Type: news

Stroke patients still not getting care they need
Care has improved in some respects but patients still miss key interventions and assessmentsRelated items from OnMedicaRate of cognitive decline increases for years after strokeEarlier thrombolysis improves stroke outcomesDementia and stroke funding remains too low, say expertsTime to rethink 4.5h window for alteplase after stroke Stroke rates rocket in younger men and women (Source: OnMedica Latest News)
Source: OnMedica Latest News - December 2, 2015 Category: UK Health Source Type: news

Self-managing anticoagulants may cut risks after surgery
All-cause mortality lower in those who self-managed after surgery to fit mechanical valvesRelated items from OnMedicaExpert review backs clot busting drug as safeTime to rethink 4.5h window for alteplase after strokeNICE recommends more INR self-monitoringSelf-monitoring cuts warfarin clot riskExtending anticoagulation duration cuts risk of VTE recurrence (Source: OnMedica Latest News)
Source: OnMedica Latest News - November 11, 2015 Category: UK Health Source Type: news

Lack of trial data may lead to wrong clinical choices
Data access should be mandatory, argue authorsRelated items from OnMedicaDoctors’ leaders consult on ethical use of dataDrug giant agrees to release all Tamiflu trial dataNICE rejects arguments against wider statin useUS doctor says FDA should have withdrawn rosuvastatinTime to rethink 4.5h window for alteplase after stroke (Source: OnMedica Latest News)
Source: OnMedica Latest News - October 23, 2015 Category: UK Health Source Type: news

Blood thinners reduce angioplasty mortality
But only in certain groups do the benefits of GPI outweigh the increased risk of bleedingRelated items from OnMedicaHeart and stroke patients not getting best medicationEarlier thrombolysis improves stroke outcomesTime to rethink 4.5h window for alteplase after strokeExtending anticoagulation duration cuts risk of VTE recurrenceBeta blockers linked to higher surgical risks (Source: OnMedica Latest News)
Source: OnMedica Latest News - October 20, 2015 Category: UK Health Source Type: news

Preventing carotid occlusion might not be reason for stenting
Preventive benefits of stenting in asymptomatic carotid stenosis no longer outweigh risks, study suggestsRelated items from OnMedicaFamily history doubles risk of aortic stenosisEarlier thrombolysis improves stroke outcomesTime to rethink 4.5h window for alteplase after strokeEndarterectomy cuts long-term stroke risk (Source: OnMedica Latest News)
Source: OnMedica Latest News - September 22, 2015 Category: UK Health Source Type: news

Expert review backs clot busting drug as safe
Review says alteplase is safe and effectiveRelated items from OnMedicaNew technology could determine use of thrombolysis post strokeUsers of HRT at risk of clots and strokeDementia and stroke funding remains too low, say expertsRate of cognitive decline increases for years after strokeTime to rethink 4.5h window for alteplase after stroke (Source: OnMedica Latest News)
Source: OnMedica Latest News - July 24, 2015 Category: UK Health Source Type: news

Provisional green light for anti-clotting drug and quality standard for atrial fibrillation
Lixiana gets provisional thumbs up while new quality standard says that an AF score of two or more merits anticoagulant treatmentRelated items from OnMedicaNational VTE Prevention Programme helping to save livesGPs to review aspirin use in atrial fibrillation patientsImprove atrial fibrillation care to stave off 11,000 strokes every year, GPs toldTime to rethink 4.5h window for alteplase after strokeExtending anticoagulation duration cuts risk of VTE recurrence (Source: OnMedica Latest News)
Source: OnMedica Latest News - July 13, 2015 Category: UK Health Source Type: news

Cholesterol drugs lower risk of stroke in healthy older adults by 30%
Study suggests drugs might be considered for preventing stroke in older peopleRelated items from OnMedicaPoor response to statins may indicate blocked arteriesStatins and dietary changes have saved 20,000 lives Stroke rates rocket in younger men and womenHigh cholesterol in 30s raises heart disease riskTime to rethink 4.5h window for alteplase after stroke (Source: OnMedica Latest News)
Source: OnMedica Latest News - May 20, 2015 Category: UK Health Source Type: news

Stroke rates rocket in younger men and women
No longer a disease of old people, as strokes soar by nearly a third in 40-54-year-old womenRelated items from OnMedicaRisk/benefit balance of alteplase shifts quicklyMen with high oestrogen levels at greater risk of breast cancerKeeping fit may delay onset of dyslipidaemiaCoalition government derailed measures to cut salt in foodTime to rethink 4.5h window for alteplase after stroke (Source: OnMedica Latest News)
Source: OnMedica Latest News - May 12, 2015 Category: UK Health Source Type: news

Stroke drug could be more widely used to clear brain blood clots
Brooks HaysEDINBURGH, Scotland, April 9 (UPI) -- New study suggests the drug alteplase is beneficial and safe for clearing blood clots in most stroke patients' brains without increased risk of bleeding. (Source: Health News - UPI.com)
Source: Health News - UPI.com - April 9, 2015 Category: Consumer Health News Source Type: news

Time to rethink 4.5h window for alteplase after stroke
After three hours, increased mortality may outweigh uncertain benefits, say researchersRelated items from OnMedicaNew technology could determine use of thrombolysis post strokeAlteplase use linked to reduction in disability after strokeMedicine watchdog launches stroke drug reviewPublic campaign has resulted in 4000 fewer people disabled by strokeEarlier thrombolysis improves stroke outcomes (Source: OnMedica Latest News)
Source: OnMedica Latest News - March 18, 2015 Category: UK Health Source Type: news

alteplase, Activase; Cathflo Activase; TPA
Title: alteplase, Activase; Cathflo Activase; TPACategory: MedicationsCreated: 12/19/2000 12:00:00 AMLast Editorial Review: 2/24/2015 12:00:00 AM (Source: MedicineNet Heart General)
Source: MedicineNet Heart General - February 24, 2015 Category: Cardiology Source Type: news

Newman's Notes: Alteplase for Ischemic Stroke (CME/CE)
(MedPage Today) -- Meta-analyses of alteplase for ischemic stroke debunked for high or unreported heterogeneity. (Source: MedPage Today Emergency Medicine)
Source: MedPage Today Emergency Medicine - October 27, 2014 Category: Emergency Medicine Source Type: news

Can fish oil reduce seizures in epilepsy?
Low-dose n-3 fatty acid supplements safe, and may cut seizure frequencyRelated items from OnMedicaStroke rate higher in HIV patientsRecurrent stroke more likely at very low BPAdding insulin to metformin linked to higher mortalityStatin use after stroke not linked to bleedsRisk/benefit balance of alteplase shifts quickly (Source: OnMedica Latest News)
Source: OnMedica Latest News - September 11, 2014 Category: UK Health Source Type: news

Medicine watchdog launches stroke drug review
Doctors concerned that clot buster alteplase can increase the risk of dangerous bleedingRelated items from OnMedicaAlteplase benefits older people tooEarlier thrombolysis improves stroke outcomesAlteplase use linked to reduction in disability after strokeAvoid BP-lowering drugs in strokeRisk/benefit balance of alteplase shifts quickly (Source: OnMedica Latest News)
Source: OnMedica Latest News - August 26, 2014 Category: UK Health Source Type: news

VIDEO: Stroke clot drug in safety review
The UK medicines watchdog, the Medicines and Healthcare Products Regulatory Agency, is to review the safety of clot-busting drug alteplase often used to treat strokes. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - August 23, 2014 Category: Consumer Health News Source Type: news

Watchdog to re-examine the safety of clot-busting stroke drug after experts found it can increase risk of bleeding on the brain 
The medicines watchdog is to review the safety of a clot-busting drug alteplase, pictured, used to treat strokes. Stoke expert Roger Shinton raised his concerns in The Lancet. (Source: the Mail online | Health)
Source: the Mail online | Health - August 23, 2014 Category: Consumer Health News Source Type: news

Experts to review stroke clot-buster
The UK medicines watchdog is setting up a review to look at the safety of alteplase, a clot-busting drug often used to treat strokes. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - August 22, 2014 Category: Consumer Health News Source Type: news

Large Analysis Supports Thrombolysis for Stroke (FREE)
By Larry Husten Edited by Lorenzo Di Francesco, MD, FACP, FHM A Lancet meta-analysis offers evidence that the use of thrombolysis should be more aggressively pursued across various subgroups of patients with ischemic stroke.Researchers examined data from nine randomized trials testing alteplase … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - August 6, 2014 Category: Primary Care Source Type: news

More Brain Bleeds With Stroke Drug in 'Real World?
BOSTON (MedPage Today) -- In a real-world practice setting, the use of tissue plasminogen activator (tPA, Alteplase) results in a higher rate of intracerebral hemorrhage than was seen in well-controlled clinical trials, researchers said here. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - May 28, 2014 Category: Cardiology Source Type: news

Alteplase uses fewer resources to manage CVC occlusion
Read the full story on MD Consult: Alteplase uses fewer resources to manage CVC occlusion (Source: MD Consult: News: Top Stories)
Source: MD Consult: News: Top Stories - May 23, 2014 Category: Journals (General) Source Type: news

Stroke survivors lose a month of healthy life for every 15 minute delay
New research published in the journal Stroke, from the American Heart Association, found that reducing delays by just a few minutes could lead to big gains     (Source: Telegraph Health)
Source: Telegraph Health - March 14, 2014 Category: Consumer Health News Tags: stroke survivors hospital ischaemic stroke alteplase Source Type: news

Gender gap in stroke treatment likely due to delay by women seeking care
Women with clot-caused strokes are less likely than men to arrive at the hospital in time to receive the best treatment, according to a European study reported in the American Heart Association journal Stroke. In the study, 11 percent of women with acute ischemic strokes were treated with the clot-dissolving medication alteplase, compared with 14 percent of men. Study participants included 5,515 patients at 12 hospitals in the Netherlands... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 29, 2013 Category: Consumer Health News Tags: Stroke Source Type: news

Alteplase Shows Lasting Benefit in Stroke SurvivorsAlteplase Shows Lasting Benefit in Stroke Survivors
Thrombolysis with alteplase has long-term benefits after stroke, although longer survival isn't among them. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 5, 2013 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news