Thrombectomy Alone Noninferior to Combination Therapy in Stroke Thrombectomy Alone Noninferior to Combination Therapy in Stroke
Although results of the DIRECT-MT trial did show noninferiority with the combination of thrombolysis and thrombectomy, they do not rule out a benefit of alteplase, researchers conclude.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - May 7, 2020 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Endovascular Thrombectomy Alone Noninferior in Ischemic Stroke
THURSDAY, May 7, 2020 -- Endovascular thrombectomy alone is noninferior to endovascular thrombectomy preceded by intravenous alteplase for patients with acute ischemic stroke from large-vessel occlusion, according to a study published online May 6... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 7, 2020 Category: Pharmaceuticals Source Type: news

Benefits of Switching to Tenecteplase for Stroke Thrombolysis Benefits of Switching to Tenecteplase for Stroke Thrombolysis
Switching from alteplase to tenecteplase as the routine thrombolytic in acute ischemic stroke is having multiple benefits for at least one US hospital system, researchers report.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - February 29, 2020 Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news

Thrombolysis Effective for Treating Occluded Central Venous Catheters in Kids Thrombolysis Effective for Treating Occluded Central Venous Catheters in Kids
Thrombolysis, particularly with alteplase, appears to be effective and likely safe for treating occluded central venous catheters in children with cancer, according to a meta-analysis.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - December 10, 2019 Category: Pathology Tags: Hematology-Oncology News Source Type: news

Widely available drug may reduce head injury deaths
Early treatment with tranexamic acid could save many lives Related items fromOnMedica Risk/benefit balance of alteplase shifts quickly Earlier thrombolysis improves stroke outcomes Alteplase use linked to reduction in disability after stroke Lengthen GP training to include dementia New guidance to prevent strokes (Source: OnMedica Latest News)
Source: OnMedica Latest News - October 15, 2019 Category: UK Health Source Type: news

Genentech Issues Voluntary Nationwide Recall of Three Lots of Activase & reg; (Alteplase)-100 mg Due to Lack of Sterility Assurance of the Sterile Water for Injection
Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), is voluntarily recalling three lots of Activase ® (alteplase) 100mg vials, that were co-packaged with Sterile Water for Injection, to the hospital level. The vials of Sterile Water for Injection, manufactured by Hospira Inc., a Pfizer company, and packaged with Activase 100 mg, may be cracked or chipped at the neck of the vial and leaking. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - July 24, 2019 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Intrapleural alteplase and domase  alfa cost effective
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - May 31, 2019 Category: Drugs & Pharmacology Source Type: news

Nerve stimulation could provide new treatment option for most common type of stroke
Research led by a UCLA scientist found that a new nerve stimulation therapy to increase blood flow could help patients with the most common type of stroke up to 24 hours after onset.A study of 1,000 patients found evidence that the technique, called active nerve cell cluster stimulation, reduced the patients ’ degree of disability three months after they suffered an acute cortical ischemic stroke, which affects the surface of the brain.Dr. Jeffrey Saver, director of theUCLA Comprehensive Stroke Center, was the co-principal investigator of the study, which was conducted at 73 medical centers in 18 countries.“We ...
Source: UCLA Newsroom: Health Sciences - May 24, 2019 Category: Universities & Medical Training Source Type: news

Large trial says aspirin safe for brain bleed stroke patients
Study says brain haemorrhage survivors should continue taking antiplatelet medicines Related items fromOnMedica Treatment of hypertension for low-risk patients questioned Avoid BP-lowering drugs in stroke Adding insulin to metformin linked to higher mortality Stroke rate higher in HIV patients Risk/benefit balance of alteplase shifts quickly (Source: OnMedica Latest News)
Source: OnMedica Latest News - May 23, 2019 Category: UK Health Source Type: news

Alteplase Seems Beneficial at 4.5 to 9.0 Hours After Stroke
THURSDAY, May 9, 2019 -- The use of alteplase between 4.5 and 9.0 hours after stroke onset results in a higher number of patients with no or minor neurological deficits, according to a study published in the May 9 issue of the New England Journal of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 9, 2019 Category: Pharmaceuticals Source Type: news

Healing time for ankle fracture could be shorter
Three weeks in a cast may be just as good as six Related items fromOnMedica Criminal sanctions fail to curb illegal drug use Commission calls for mental health parity in Northern Ireland Low back pain often wrongly treated worldwide Frail elderly at greatest risk after trauma surgery Risk/benefit balance of alteplase shifts quickly (Source: OnMedica Latest News)
Source: OnMedica Latest News - January 24, 2019 Category: UK Health Source Type: news

Fibrinolytic No Help for Microvascular Obstruction in PCI
(MedPage Today) -- Low-dose alteplase flops in T-TIME trial (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - January 9, 2019 Category: Cardiology Source Type: news

T-TIME: Low-dose Alteplase No Match for Microvascular Obstruction T-TIME: Low-dose Alteplase No Match for Microvascular Obstruction
Microvascular obstruction, perceived as the'final frontier'in ST-segment elevation MI, failed to yield to low-dose intracoronary alteplase.Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 15, 2018 Category: Consumer Health News Tags: Cardiology News Source Type: news

UCalgary researchers discover critical differences in the clots that cause a stroke
(University of Calgary) There are two main treatments for stroke caused by a clot in a blood vessel in the brain. University of Calgary scientists with the Hotchkiss Brain Institute at the Cumming School of Medicine have discovered that clots have different compositions and depending on where they are located in the brain, administering the clot-busting drug, Alteplase (also known as tPA), can be almost as effective as thrombectomy given sufficient time. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 11, 2018 Category: International Medicine & Public Health Source Type: news

May 18, 2018 This Week in Cardiology May 18, 2018 This Week in Cardiology
Device-related thrombosis with Watchman left atrial appendage closure, debulking atrial fibrillation after ablation, rivaroxaban for stroke prevention, alteplase, and Lp(a) are discussed this week.theheart.org on Medscape (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 18, 2018 Category: Consumer Health News Tags: Cardiology Commentary Source Type: news

Tenecteplase: Thrombolytic of Choice in Stroke? Tenecteplase: Thrombolytic of Choice in Stroke?
The EXTEND-IA TNK trial suggesting better outcomes with tenecteplase than alteplase in the treatment of acute ischemic stroke has now been published in the New England Journal of Medicine.Medscape Medical News (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - April 26, 2018 Category: Intensive Care Tags: Neurology & Neurosurgery News Source Type: news

Tenecteplase Appears Superior to Alteplase After Ischemic Stroke
THURSDAY, April 26, 2018 -- For patients with ischemic stroke, treatment with tenecteplase within 4.5 hours of symptom onset and before thrombectomy is associated with better outcomes than treatment with alteplase during the same timeframe,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 26, 2018 Category: Pharmaceuticals Source Type: news

TNKase (Tenecteplase): A Better Clot-Buster Drug for Strokes?
THURSDAY, April 26, 2018 -- After a stroke, many patients are given the clot-busting intravenous drug alteplase, but another drug may be more effective, Australian researchers report. Among more than 200 stroke victims, TNKase (tenecteplase) was... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 26, 2018 Category: General Medicine Source Type: news

A Better Clot-Buster Drug for Strokes?
THURSDAY, April 26, 2018 -- After a stroke, many patients are given the clot-busting intravenous drug alteplase, but another drug may be more effective, Australian researchers report. Among more than 200 stroke victims, TNKase (tenecteplase) was... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 26, 2018 Category: General Medicine Source Type: news

Cathflo Activase (Alteplase Powder for Reconstitution for Use in Central Venous Access Devices) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 19, 2018 Category: Drugs & Pharmacology Source Type: news

Tenecteplase Superior to Alteplase for Stroke Thrombolysis Tenecteplase Superior to Alteplase for Stroke Thrombolysis
A noninferiority study shows the successful reperfusion rate was doubled in patients scheduled for thrombectomy who received tenecteplase compared with the current standard, alteplase.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 26, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Tenecteplase Superior to Alteplase for Stroke Lysis
(MedPage Today) -- But likelihood of gaining an official stroke indication appears remote (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - January 25, 2018 Category: Cardiology Source Type: news

Ischemic stroke patients not receiving life-saving treatment, study finds
(Georgia State University) Ischemic stroke patients who do not receive intravelous (IV) alteplase, a clot-dissolving medication, are significantly less likely to survive, according to researchers at Georgia State University. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 12, 2017 Category: International Medicine & Public Health Source Type: news

Recalled in US: Three Lots of Alteplase (Activase), Vial Leakage Hazard Recalled in US: Three Lots of Alteplase (Activase), Vial Leakage Hazard
Genentech says the thrombolytic agent in 100 mg vials was copackaged with sterile water for injection; the water vials may be"cracked or chipped" and no longer sterile.News Alerts (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 7, 2017 Category: Consumer Health News Tags: Cardiology News Alert Source Type: news

Genentech Issues Voluntary Nationwide Recall of Three Lots of Activase & reg; (Alteplase)-100 mg Due to Lack of Sterility Assurance of the Sterile Water for Injection
Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), is voluntarily recalling three lots of Activase ® (alteplase) 100mg vials, that were co-packaged with Sterile Water for Injection, to the hospital level. The vials of Sterile Water for Injection, manufactured by Hospira Inc., a Pfizer company, and packaged with Activase 100 mg, may be cracked or chipped at the neck of the vial and leaking. (Source: Food and Drug Administration)
Source: Food and Drug Administration - September 7, 2017 Category: Food Science Source Type: news

Tenecteplase Not Better or Safer in Ischemic Stroke
(MedPage Today) -- First head-to-head trial shows no advantage against alteplase (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - August 3, 2017 Category: American Health Source Type: news

Cathflo Activase (Alteplase Powder for Reconstitution for Use in Central Venous Access Devices) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - July 12, 2017 Category: Drugs & Pharmacology Source Type: news

Memphis Mobile Stroke Unit Saves Lives
A year after a mobile stroke unit hit the streets of Memphis, officials say it is saving lives by cutting the time it takes to treat stroke patients. The University of Tennessee Health Science Center began using the 14-ton ambulance last year as part of a three-year controlled study. The unit has a CT scanner that can X-ray images of the brain, and is equipped to provide early fluids to stroke patients and dye blood vessels to determine the type of stroke the patient has had. "The emergency room on average takes 40 to 50 minutes to do the things we do in 13 to 14 minutes," said Dr.Andrei Alexandrov, UTHSC neurolo...
Source: JEMS Special Topics - June 10, 2017 Category: Emergency Medicine Authors: Olivia Peterkin, The Commercial Appeal Tags: News Mobile Integrated Healthcare Source Type: news

Memphis Mobile Stroke Unit Saves Lives
A year after a mobile stroke unit hit the streets of Memphis, officials say it is saving lives by cutting the time it takes to treat stroke patients. The University of Tennessee Health Science Center began using the 14-ton ambulance last year as part of a three-year controlled study. The unit has a CT scanner that can X-ray images of the brain, and is equipped to provide early fluids to stroke patients and dye blood vessels to determine the type of stroke the patient has had. "The emergency room on average takes 40 to 50 minutes to do the things we do in 13 to 14 minutes," said Dr.Andrei Alexandrov, UTHSC neurolo...
Source: JEMS: Journal of Emergency Medical Services News - June 10, 2017 Category: Emergency Medicine Authors: Olivia Peterkin, The Commercial Appeal Tags: News Mobile Integrated Healthcare Source Type: news

NOR-TEST: Tenecteplase Similar to Alteplase in Stroke NOR-TEST: Tenecteplase Similar to Alteplase in Stroke
The newer thrombolytic given as a bolus dose showed functional and safety outcomes similar to those of alteplase infusion in the NOR-TEST trial.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 19, 2017 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Lori’s Stroke Required Help From Doctors An Hour Away. Telemedicine Provided It.
Editor’s note: Our previous stories this American Stroke Month featured warning signs heeded and missed. Today we shift gears to showcase a textbook response to a stroke, including the crucial role of telestroke, a way for experts at another facility to help care for a patient via a webcam-type connection. The CHRONIC Care Act, which includes a provision to require Medicare to cover telestroke, will be discussed Tuesday during a hearing of the Senate Finance Committee. Lori Hoopingarner savored her occasional weekend getaway. Between running her financial advising company, raising a 10-year-old daughter and 6-year-o...
Source: Healthy Living - The Huffington Post - May 15, 2017 Category: Consumer Health News Source Type: news

MassDevice.com +5 | The top 5 medtech stories for February 24, 2017
Say hello to MassDevice +5, a bite-sized view of the top five medtech stories of the day. This feature of MassDevice.com’s coverage highlights our 5 biggest and most influential stories from the day’s news to make sure you’re up to date on the headlines that continue to shape the medical device industry. Get this in your inbox everyday by subscribing to our newsletters. 5. FDA panel supports Claret Medical’s Sentinel, despite efficacy questions The FDA’s Circulatory System Devices Panel this week gave its support to de novo clearance for Claret Medical’s Sentinel embolic protection dev...
Source: Mass Device - February 24, 2017 Category: Medical Equipment Authors: Brad Perriello Tags: News Well Plus 5 Source Type: news

Stroke Care: A Balanced Approach to the tPA Debate
In conclusion, alteplase is the only treatment available for acute ischemic stroke that is effective in some patients. In order to improve tPA effectiveness and minimize risks, patients with symptoms suggestive of an AIS should get rapid assessment and treatment with tPA after careful review of the contraindications. Given that smaller strokes can still be associated with considerable long term neurological morbidity, treatment should still be considered in those patients after weighing the risks and benefits and in consultation with the patient and family. Advanced age should also not be a limiting factor. Although the NI...
Source: EPMonthly.com - December 31, 2016 Category: Emergency Medicine Authors: Logan Plaster Tags: Uncategorized Source Type: news

alteplase (TPA, Activase, Cathflo Activase)
Title: alteplase (TPA, Activase, Cathflo Activase)Category: MedicationsCreated: 12/19/2000 12:00:00 AMLast Editorial Review: 11/3/2016 12:00:00 AM (Source: MedicineNet Heart General)
Source: MedicineNet Heart General - November 3, 2016 Category: Cardiology Source Type: news

A Paradigm Shift in EMS Evaluation Of Stroke
Background Montgomery County Hospital District EMS (MCHD) is collaborating with the South East Texas Regional Advisory Committee (SETRAC) to validate their existing prehospital suspected neurological event guideline for stroke assessment and transport. MCHD is a non-fire based EMS service in Montgomery County, Texas. We respond to approximately 58,000 calls to service and identify stroke in more than 500 patients per year. Our EMS system covers an estimated 1,100-square-mile service area and has 190 medics, 900 EMTs and 15 first responder (FR) organizations. Acute ischemic stroke (AIS) is a debilitating and costly disease ...
Source: JEMS Patient Care - August 12, 2016 Category: Emergency Medicine Authors: Robert L. Dickson, MD, FAAEM, FACEP, FACEM Tags: Patient Care Source Type: news

A Paradigm Shift in EMS Evaluation Of Stroke
BackgroundMontgomery County Hospital District EMS (MCHD) is collaborating with the South East Texas Regional Advisory Committee (SETRAC) to validate their existing prehospital suspected neurological event guideline for stroke assessment and transport.MCHD is a non-fire based EMS service in Montgomery County, Texas. We respond to approximately 58,000 calls to service and identify stroke in more than 500 patients per year. Our EMS system covers an estimated 1,100-square-mile service area and has 190 medics, 900 EMTs and 15 first responder (FR) organizations.Acute ischemic stroke (AIS) is a debilitating and costly disease wit...
Source: JEMS Patient Care - August 12, 2016 Category: Emergency Medicine Authors: Robert L. Dickson, MD, FAAEM, FACEP, FACEM Tags: Patient Care Source Type: news

Alteplase confers long-term survival benefit after stroke
Alteplase treatment in patients with acute ischaemic stroke is associated with a survival benefit among those who survive the acute phase, shows further analysis of IST-3. (Source: MedWire News)
Source: MedWire News - July 26, 2016 Category: Consumer Health News Tags: Stroke Source Type: news

MHRA review confirms benefit/risk profile of Alteplase - the only licensed clot buster for acute ischaemic stroke
(Source: Boehringer Ingelheim Corporate News)
Source: Boehringer Ingelheim Corporate News - July 25, 2016 Category: Research Source Type: news

NICE recommends treatment with alteplase is started as early as possible, within 4.5 hours of onset of ischaemic stroke symptoms
(Source: Boehringer Ingelheim Corporate News)
Source: Boehringer Ingelheim Corporate News - July 25, 2016 Category: Research Source Type: news

Activase (Alteplase) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - July 12, 2016 Category: Drugs & Pharmacology Source Type: news

alteplase (Activase, Cathflo Activase, TPA)
Title: alteplase (Activase, Cathflo Activase, TPA)Category: MedicationsCreated: 12/19/2000 12:00:00 AMLast Editorial Review: 5/31/2016 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - May 31, 2016 Category: Drugs & Pharmacology Source Type: news

Reducing doses of common stroke drug 'could save thousands of lives'
Reducing the dose of alteplase – taken by one in nine stroke patients – would slash brain bleeds by two thirds and death rates by a sixth, according to an international study led by Leicester University. (Source: the Mail online | Health)
Source: the Mail online | Health - May 11, 2016 Category: Consumer Health News Source Type: news

ENCHANTED results challenge reduced alteplase dose in Asian stroke patients
A reduced dose of alteplase has failed to prove itself noninferior to the standard dose in a predominantly Asian population of patients with ischaemic stroke. (Source: MedWire News)
Source: MedWire News - May 10, 2016 Category: Consumer Health News Tags: Stroke Source Type: news

Seeking an alteplase alternative for stroke
Where is a biosimilar when you need one? A few weeks ago, I reported on an advisory committee of the Food and Drug Administration overwhelmingly recommending that the agency approve a biosimilar... (Source: Family Practice News)
Source: Family Practice News - March 8, 2016 Category: Primary Care Source Type: news

Seeking an alteplase alternative for stroke
Where is a biosimilar when you need one? A few weeks ago, I reported on an advisory committee of the Food and Drug Administration overwhelmingly recommending that the agency approve a biosimilar... (Source: Clinical Neurology News)
Source: Clinical Neurology News - March 8, 2016 Category: Neurology Source Type: news

VIDEO: A better way to treat large intraventricular hemorrhages
LOS ANGELES – For intraventricular hemorrhages of at least 20 mL, alteplase (Activase – Genentech) delivered directly into the clot by external ventricular drain almost doubles the odds of achieving... (Source: Family Practice News)
Source: Family Practice News - February 29, 2016 Category: Primary Care Source Type: news

VIDEO: A better way to treat large intraventricular hemorrhages
LOS ANGELES – For intraventricular hemorrhages of at least 20 mL, alteplase (Activase – Genentech) delivered directly into the clot by external ventricular drain almost doubles the odds of achieving... (Source: Clinical Neurology News)
Source: Clinical Neurology News - February 29, 2016 Category: Neurology Source Type: news

Clot-busting drug improves survival for deadly form of stroke
Stephen FellerLOS ANGELES, Feb. 18 (UPI) -- Clot-busting drug Alteplase, used for heart attacks and non-bleeding strokes, can reduce disability and mortality in patients with a type of bleeding stroke. (Source: Health News - UPI.com)
Source: Health News - UPI.com - February 18, 2016 Category: Consumer Health News Source Type: news

Medtronic touts Solitaire stent retriever meta-analysis
The Solitare stent retriever Medtronic (NYSE:MDT) acquired for $50 billion last year when it bought Covidien is safe and highly effective when combined with standard care using the thrombolysis drug alteplase, according to a meta-analysis of 4 previous trials of the device. The transcatheter Solitaire device uses a stent-like device to trap and retrieve a blood clot in the brain in cases of ischemic stroke. Researchers from the 4 trials – Swift Prime, Revascat, Extend-IA and Escape – pooled their data to examine the results from 787 patients, randomized to either thrombectomy with the Solita...
Source: Mass Device - February 18, 2016 Category: Medical Equipment Authors: Brad Perriello Tags: Clinical Trials Neurological Vascular Medtronic Stroke Source Type: news