Small Non-coding RNAs: New Class of Biomarkers and Potential Therapeutic Targets in Neurodegenerative Disease
Conclusion The key problem with the ND field is the lack of understanding in the events preceding the development of protein-based markers – such as Tau – currently used to diagnose NDs. By this stage, the diseases become more difficult to treat. SncRNAs play an important regulatory role in the maintenance of the homeostatic brain. Therefore, changes in their concentration levels can be indicative of mechanistic changes that could precede protein-based markers. One single sncRNA biomarker is unlikely to differentiate between diseases. However, a combination of sncRNA biomarkers could be illustrative of the mechanistic development of NDs to enable early diagnosis, enhanced disease monitoring as well as defining subtle differences between NDs. Consequently, novel treatment methods directly related to their mechanistic underpinning of specific NDs, and potentially other brain related pathologies can be envisaged. Novel, less-well studied sncRNAs could be integral to understanding the overall disease progression. So new methodologies may be necessary to quantify these changes and allow for future biomarker development. Author Contributions CW drafted the manuscript. AB and VDP critically revised the manuscript. Funding This study was funded by the National Institute for Health Research (NIHR). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. Conflict of Interest Statement The authors de...
The separation of the brain from blood by the blood-brain barrier and the bloodcerebrospinal fluid (CSF) barrier poses unique challenges for the discovery and development of drugs targeting the central nervous system (CNS). This review will describe the role of transporters in CNS penetration and examine the relationship between unbound brain (Cu-brain) and unbound plasma (Cu-plasma) or CSF (CCSF) concentration. Published data demonstrate that the relationship between Cu-brain and Cu-plasma or CCSF can be affected by transporter status and passive permeability of a drug and CCSF may not be a reliable surrogate for CNS pene...
Conclusion: Imatinib is not a substrate of OCTs 1-3 while the environmental pH modulates cellular disposition of imatinib. The observation that a slightly acidic extracellular pH influences imatinib cellular accumulation is important, considering the low extracellular pH reported in the hematopoietic leukemia/ cancer cell microenvironment.
Publication date: Available online 29 June 2020Source: Saudi Pharmaceutical JournalAuthor(s): Mohamed N Al Arifi
Publication date: September 2020Source: Biomedicine &Pharmacotherapy, Volume 129Author(s): Mengyun Yuan, Xi Zou, Shenlin Liu, Xintian Xu, Hongxing Wang, Min Zhu, Xiaodong Xie, Haidan Wang, Jian Wu, Qingmin Sun
Publication date: September 2020Source: Biomedicine &Pharmacotherapy, Volume 129Author(s): Mahdi Mirahmadi, Shayan Azimi-Hashemi, Ehsan Saburi, Hossein Kamali, Mandana Pishbin, Farzin Hadizadeh
Publication date: July 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 7Author(s): Yu-Chi CHEN, Mu-Yang HUANG, Le-Le ZHANG, Zhe-Ling FENG, Xiao-Ming JIANG, Luo-Wei YUAN, Run-Yue HUANG, Bo LIU, Hua YU, Yi-Tao WANG, Xiu-Ping CHEN, Li-Gen LIN, Jin-Jian LU
Publication date: July 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 7Author(s): Qiu-Mei FAN, Wen-Tong ZHAO, Renyikun YUAN, Qin-Qin WANG, Li-Feng ZHANG, Hong-Wei GAO, Jing LENG, Shi-Lin YANG
Publication date: July 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 7Author(s): Ling CHEN, Man-Yun CHEN, Li SHAO, Wei ZHANG, Tai RAO, Hong-Hao ZHOU, Wei-Hua HUANG
Publication date: July 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 7Author(s): Si-Yuan JING, Zi-Dan WU, Tie-Hua ZHANG, Jie ZHANG, Zheng-Yi WEI
Publication date: July 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 7Author(s): Jin-Jian LU, Yi-Tao WANG
More News: Addison's Disease | Alcoholism | ALS | Alzheimer's | Ataxia | Autism | Biotechnology | Brain | Brain Cancers | Breast Cancer | Cancer | Cancer & Oncology | Cardiology | Cardiovascular | Clinical Trials | Databases & Libraries | Deep Brain Stimulation | Dementia | Disability | Fish | Genetics | Heart | Huntington's Disease | Lessons | Liver | Men | Microbiology | Mitochondrial Disease | Molecular Biology | Motor Neurone Disease | MRI Scan | Multiple Sclerosis | National Institute for Health Research (NIHR) | Neurology | Neuroscience | Nutrition | Opthalmology | Parkinson's Disease | Pathology | Pfizer | Pregnancy | Pregnancy and Breast Cancer | Psychiatry | Retinitis Pigmentosa | Sarcomas | Science | Spinal Cord Injury | Spinal Muscular Atrophy | Stem Cell Therapy | Stem Cells | Study | UK Health | Urology & Nephrology | USA Health | Zucchinis