Medicine: the appliance of science
A cure for HIV? A new approach to obesity? Tailor-made therapies for cancer? Medical science surges aheadMore than once last year, researchers described leaps in medical science that were so breathtaking, and held so much potential for patients, that they immediately joined the list of fields to watch in the year ahead. In most cases, the work was, and is, at an early stage and its future success far from certain. Such is the nature of science. Most of today's breakthroughs will be tomorrow's failures. But some may go down in history for transforming how medicine is done.Often, medical science surges ahead when different areas converge. That's the case with genome editing, which gives scientists the extraordinary ability to rewrite genes in living organisms. At the heart of the process are enzymes that can sever DNA at chosen locations. But to be useful, it required advances in computational genetics, and exquisite techniques to manipulate biological cells.Then there is the microbiome, the name given to the community of microbes that lives in and on our bodies. The trillions of bacteria that live in our guts, for example, influence our development, our metabolism, and our risk of scores of diseases. The prospect of treating, or preventing disease, through manipulating the microbiome, encouraging some bugs here, and fewer there, is a radical departure for medicine that now looks entirely realistic.Cost is one of the greatest barriers to medical progress, so the falling price o...
ConclusionsFOSL1 is an independent prognostic biomarker of GC. Detecting FOSL1 expression could help stratify GC patients with high-risk and guide the precious treatment.
In this study, we aimed to investigate the role of IL-6/Stat3 signaling pathway in human endometrial cancer cells invasion and migration. We demonstrated that Stat3 is activated in endometrial cancer cell lines. To investigate the role of Stat3 in endometrial cancer invasive capacity, we used Stat3 inhibitor Stattic and found that Stattic significantly inhibited the migration and invasion of endometrial cancer cells elevated by IL-6. Furthermore, we showed that Stat3 inhibitor significantly decreased the expression of MMP2 enhanced by IL-6, indicating that IL-6 promoted endometrial cancer invasion and migration by Stat3-in...
Publication date: Available online 19 March 2019Source: Pathology - Research and PracticeAuthor(s): Xiaobo He, Ying ShuAbstractIncreasing evidence has shown that dysregulation of mircoRNA (miRNA) is linked to the development and progression of human cancer, including gastric cancer (GC). In the current study, by analysing the GEO database (GSE78091), we found that miR-660 was significantly downregulated in GC. Consistently, quantitative real-time PCR (qRT-PCR) results showed that miR-660 was dramatically decreased in GC tissues and cell lines. Importantly, low miR-660 expression was closely related to larger tumor size (P&...
ConclusionsThe results pointed out that the high expression of miR-106b-5p serves as an independent factor for predicting the worse prognosis of RCC patients.
Conclusions: DIM is a very rare tumour. The global survival is excellent. Conservative treatment with PT is an efficient alternative to enucleation and allows good local tumour control. Cataract and glaucoma are the main radiation-related complications, but the corneal status was excellent due to the stem cell harvest prior to radiotherapy.Ocul Oncol Pathol
Conclusion: There are no relevant differences between men and women in ocular or patient survival after brachytherapy for uveal melanoma.Ocul Oncol Pathol
Conclusions: Conjunctival melanocytic lesions suspicious for melanocytoma should be bleached to evaluate their cytologic features. CD68 can be helpful in identifying heavily pigmented melanomacrophages which may mimic a melanocytoma. As conjunctival melanocytomas are extremely rare, their pathogenesis may be different from that of other conjunctival nevi.Ocul Oncol Pathol
Publication date: Available online 28 February 2019Source: Journal of Minimally Invasive GynecologyAuthor(s): Sadikah Behbehani, Tiffany Pham, Katie Kunze, Megan Wasson, Johnny YiABSTRACTStudy ObjectiveTo determine the incidence of a successful in-office voiding trial after minimally invasive hysterectomy.DesignA retrospective cohort study.SettingA tertiary care academic center.PatientsAll patients undergoing minimally invasive hysterectomies (vaginal, laparoscopic, or robotic) from January 2013 to July 2018 who have an unsuccessful voiding trial in the postoperative unit.InterventionsA voiding trial.Measurements and Main ...
In conclusion, clinical presentation at time of diagnosis of brain metastases consistently includes neurologic signs and symptoms with persistent headache being the most common. Endometrial cancer patients that present with new neurologic complaints or exam findings should be evaluated for brain metastases.
Conclusions: BMI and WC may predict incident hypertension better than skinfold thickness, WHR, and WHTR in the Chinese population.Ann Nutr Metab 2019;74:215 –223
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