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Medicine: the appliance of science

A cure for HIV? A new approach to obesity? Tailor-made therapies for cancer? Medical science surges aheadMore than once last year, researchers described leaps in medical science that were so breathtaking, and held so much potential for patients, that they immediately joined the list of fields to watch in the year ahead. In most cases, the work was, and is, at an early stage and its future success far from certain. Such is the nature of science. Most of today's breakthroughs will be tomorrow's failures. But some may go down in history for transforming how medicine is done.Often, medical science surges ahead when different areas converge. That's the case with genome editing, which gives scientists the extraordinary ability to rewrite genes in living organisms. At the heart of the process are enzymes that can sever DNA at chosen locations. But to be useful, it required advances in computational genetics, and exquisite techniques to manipulate biological cells.Then there is the microbiome, the name given to the community of microbes that lives in and on our bodies. The trillions of bacteria that live in our guts, for example, influence our development, our metabolism, and our risk of scores of diseases. The prospect of treating, or preventing disease, through manipulating the microbiome, encouraging some bugs here, and fewer there, is a radical departure for medicine that now looks entirely realistic.Cost is one of the greatest barriers to medical progress, so the falling price o...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: The Guardian Genetics Biology Medical research Microbiology Society Features Cancer Aids and HIV Chemistry Biochemistry and molecular biology Science Source Type: news

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Authors: Sawicka-Żukowska M, Krawczuk-Rybak M, Bernatowicz P, Muszyńska-Rosłan K, Konstantynowicz J, Łuczyński W Abstract The study objective was to assess the prevalence of cardiovascular disease risk factors in patients treated for childhood cancer (N = 101) and to determine the involvement of clinical (cancer type and therapy) and/or genetic (FTO gene rs9939609 polymorphism) factors. Anthropometric features, laboratory findings, and standardized osteodensitometric indices (fat and lean mass) were considered. Overweight/obesity was found in 17.82% of the patients; however, central adiposity was found in as m...
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
Conclusion: The eIF2α polymorphism is associated with islet β-cell function in a Chinese population. PMID: 29675042 [PubMed]
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
A THERAPY that could make lung cancer treatable is “one of the biggest breakthroughs in cancer in years”. It combines two drugs and “decloaks” the cancer, revealing it to the body’s immune system that in turn attacks it.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
In conclusion, Buxus sempervirens leaf extract may be helpful in controlling the development of hyperlipidemia as well as atherosclerosis in diabetic animals. PMID: 29669507 [PubMed - as supplied by publisher]
Source: Cardiovascular and Hematological Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research
CONCLUSION: SOCS1 promoter methylation level is not suitable to be used as one of the biomarker for predicting the possibility of acquiring resistance among CML patients treated with IM. PMID: 29669505 [PubMed - as supplied by publisher]
Source: Cardiovascular and Hematological Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research
Authors: Klein S, Aung T, Haas RM, Medved F, Schiller SM, Felthaus O, Dolderer JH Abstract Soft tissue defects resulting from injuries, tumor resection, congenital anomalies or chronic wounds pose a great challenge to reconstructive surgery. The current gold standard in therapy of such defects is the tissue transplantation in terms of free or local flaps. Unfortunately, donor site morbidity remains a considerable risk of flap surgery. Therefore, tissue engineering of autologous vascularized long term stable adipose tissue constructs could enrich the therapeutic possibilities of soft tissue defects. De novo adipose ...
Source: Handchirurgie Mikrochirurgie Plastische Chirurgie - Category: Cosmetic Surgery Tags: Handchir Mikrochir Plast Chir Source Type: research
Conclusion. Evidence from the meta-analysis suggested that JPBS combined with chemotherapy has a positive effect on gastric cancer treatment. However, additional rigorously designed and large sample randomized controlled trials are required to confirm the efficacy and safety of this treatment. PMID: 29675052 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Authors: Cai Y, Wang Y, Zhi F, Xing QC, Chen YZ Abstract Treating type 2 diabetes mellitus (T2DM) using thiazolidinediones and biguanides can present several challenges for patients. Sanggua Drink (SGD) is a commonly used agent in traditional Chinese medicine, and it consists of Folium Mori, Fructus Momordicae Charantiae, Radix Puerariae Lobatae, and Rhizoma Dioscorea. The hypoglycemic effects and mechanisms of SGD extracts on insulin resistance in diabetic rats were investigated. SGD (1.24 g/kg orally) was verified in T2DM rats induced by a high-fat diet and streptozotocin. The results showed that SGD treat...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Authors: Li H, Chu S, Zhao H, Liu D, Liu X, Qu X, Chen J, Li Z, Li J Abstract Diabetic osteoporosis (DO) is a complication of diabetes. Zishen Jiangtang Pill (ZJP) is a Chinese herbal product which has been used in clinic to maintain blood glucose level and bone density for decades. However, the evidence about its mechanism on diabetes and osteoporosis is still unknown. The aim of this study is to investigate therapeutic effect of ZJP on DO in streptozotocin- (STZ-) induced rats. Rats were randomly assigned to 4 groups: one control group (CON), one model group (MOD), and two ZJP treatment groups (1.5 and 3.0&thinsp...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
This study suggested that the stem extract of A. sessilis might be a potential therapeutic agent for skin wound healing, supporting its traditional medicinal uses. PMID: 29670658 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
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