Beneficial Effects of Remifentanil Against Excitotoxic Brain Damage in Newborn Mice

Conclusions: In vivo exposure to remifentanil exerts a beneficial effect against excitotoxicity on the developing mouse brain, which is associated with a reduction in the size of ibotenate-induced brain lesion as well as prevention of some behavioral deficits in young mice. The long-term effect of neonatal exposure to remifentanil should be investigated. Introduction The potential neurotoxicity of anesthetics in the perinatal period prompted the US Food and Drug Administration (FDA) to release a drug safety communication warning in 2016 that stated, “repeated or lengthy use of general anesthetics or sedation drugs during surgeries or procedures in children younger than 3 years of age or in pregnant women during the final trimester may affect development of children's brains” (1). Use of anesthetics in the perinatal period is, therefore, a particularly delicate matter, and obstetric anesthesiologists have to weigh risks and benefits in order to make decisions regarding the exposure of the developing brain to anesthetics; on the one hand, it is ethically essential to relieve pain of the parturient during labor or cesarean section, while on the other hand, anesthetics, including opioids, are potentially deleterious to brain development when used during the fetal period or before 3 years of age (2). Indeed, exposure to anesthetics is associated with altered neuronal proliferation and degeneration as well as behavioral disturbances in animal studies (3)...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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Publication date: Available online 20 October 2019Source: Journal of Vocational BehaviorAuthor(s): Emmanuelle Vignoli, Nathalie Prudhomme, Katia Terriot, Valérie Cohen-Scali, Caroline Arnoux-Nicolas, Jean-Luc Bernaud, Noëlle LallemandAbstractThe first aim of this study was to validate a French version of the Decent Work Scale (DWS) proposed by Duffy, Allan, Blustein, England, Douglass, Ferreira, and Santos (2017). Our second aim was to gain insight into French people's representations of decent work using a qualitative approach. A representative sample of 300 French employees completed the DWS, as well as measu...
Source: Journal of Vocational Behavior - Category: Psychiatry & Psychology Source Type: research
Publication date: Available online 20 October 2019Source: International Journal of PsychophysiologyAuthor(s): Eliana Vassena, Filip Van Opstal, Ingeborg Goethals, Tom VergutsAbstractThe ability to exert control has been widely investigated as a hallmark of adaptive behaviour. Dopamine is recognized as the key neuromodulator mediating various control-related processes. The neural mechanisms underlying the subjective perception of being in control, or Locus of Control (LOC) are however less clear. LOC indicates the subjective tendency to attribute environmental outcomes to one's actions (internal LOC) or instead to external ...
Source: International Journal of Psychophysiology - Category: Psychiatry & Psychology Source Type: research
This article discusses the creation of the Norm and Deviance-Seeking Personal Orientation Scale (NDPOS). To create this sc ale, we studied the psychometric properties of the instrument using data from French workers. NDPOS exploratory analysis indicated a 12-item scale composed of four factors: normative conformity, normative rule adequacy, deviant performance seeking, and deviant proactivity seeking. Confirmatory facto r analysis corroborated the factorial structure in four sub-scales. Convergent and discriminant validity indicated that deviant dimensions were positively related to expressing voice, cognitive flexibility,...
Source: Psychologica Belgica - Category: Psychiatry & Psychology Source Type: research
Objective: To compare the rate of malreduction after high fibular fractures associated with syndesmosis injury treated with open reduction and internal fixation, with either 2 screws or 1 knotless TightRope device. Design: Prospective randomized controlled multicenter trial. Setting: Eleven academic and community hospitals including Level 1 and Level 2 trauma centers across Canada. Patients/Participants: One hundred three patients with OTA/AO 44-C injuries with demonstrated radiographic syndesmosis diastasis or instability after malleolar bony fixation were followed for 12 months after treatment. Methods: Ope...
Source: Journal of Orthopaedic Trauma - Category: Orthopaedics Tags: Original Article Source Type: research
Conclusions: Results suggest TCC may have a small positive effect on early outcomes, but use of the services was highly variable among sites. Level of Evidence: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Source: Journal of Orthopaedic Trauma - Category: Orthopaedics Tags: Original Article Source Type: research
Conclusions: Three thousand eight hundred ten articles were identified, and 12 met inclusion criteria. These studies encompassed 497 patients with an average age of 14.1 years (8–18 years, range). Both operative and nonoperative management of displaced midshaft clavicle fractures in this population provide excellent rates of union and patient-reported outcome measures. Compared with nonoperative management, operative management yielded faster return to activity, superior Constant scores, and equal QuickDASH scores. Operative management had higher complication rates and complications that required secondary operativ...
Source: Journal of Orthopaedic Trauma - Category: Orthopaedics Tags: Review Article Source Type: research
Authors: Arezoomandan R, Aliaghaei A, Khodagholi F, Haghparast A Abstract Glial glutamate transporters (GLT-1) is responsible for glutamate homeostasis. GLT-1 expression and glutamate uptake can be affected by addictive drugs and can be used as a target in addiction pharmacotherapy. It has been shown that minocycline, an antibiotic with anti-inflammatory, and neuroprotective properties, can upregulate the expression of GLT-1. In the present study, in morphine-dependent rats, the effect of minocycline on expression of GLT-1 in nucleus accumbens was investigated by immunohistochemistry. The expression of GLT-1 signif...
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
This study explored the association between serum vitamin D levels and urinary tract infections in pregnant women.Study designIn this case control study, 187 participants including, 97 pregnant women diagnosed as a symptomatic UTI (case group) and 90 matched healthy pregnant women (control group) were consecutively enrolled from prenatal care clinic of Imam Reza Hospital in Urmia, North West of Iran. The two groups were matched for trimester and parity, and sexual intercourse. Blood samples were collected from both groups. Chemiluminescent immunoassay (CLIA) was used to evaluate the serum vitamin D levels. We used a binary...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Publication date: Available online 21 October 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Charline Bertholdt, Manuel Gomes David, Priscillia Gabriel, Olivier Morel, E. Perdriolle-GaletAbstractObjectivesThe main objective of this study was to assess the induction-to-delivery interval with or without the use of osmotic dilators for induced abortion. As secondary objectives, women outcomes were assessed.Study designThis retrospective single-center observational before and after study reviewed records from a university hospital maternity unit from 2002 through 2016 and included...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
STOMACH bloating is usually remedied by making simple dietary changes. If quick fixes do not alleviate the tummy swelling, this may signal a more serious condition, including one that specifically affects women.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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