Increasing Upstream Chromatin Long –Range Interactions May Favor Induction of Circular RNAs in LysoPC-Activated Human Aortic Endothelial Cells

Increasing Upstream Chromatin Long–Range Interactions May Favor Induction of Circular RNAs in LysoPC-Activated Human Aortic Endothelial Cells Angus Li1,2†, Yu Sun1†, Charles Drummer IV1, Yifan Lu1, Daohai Yu3, Yan Zhou4, Xinyuan Li1, Simone J. Pearson1, Candice Johnson1, Catherine Yu5, William Y. Yang1, Kevin Mastascusa1, Xiaohua Jiang1, Jianxin Sun6, Thomas Rogers7, Wenhui Hu1, Hong Wang1 and Xiaofeng Yang1,7* 1Center for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States 2Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, United States 3Department of Clinical Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States 4Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, Temple Health, Philadelphia, PA, United States 5Geisinger Commonwealth School of Medicine, Scranton, PA, United States 6Center for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Philadelphia University – Thomas Jefferson University, Philadelphia, PA, United States 7Center for Inflammation, Translational and Clinical Lung Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States Circular RNAs (circRNAs) are non-coding RNAs that form covalently closed continuous loops, and act as gene regulators in physiological and disease conditions. To test our hypothes...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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CONCLUSION: This study confirmed published results that labour progresses more slowly as maternal BMI increases. The study was performed in a centre with a specialized BMI pregnancy clinic; thus weight gain adherence, awareness of labour differences, and patient counselling may have contributed to low Caesarean section rates. Obstetric care providers should consider differences in maternal BMI in labour progression before undertaking a potentially premature Caesarean birth, especially in primiparas. PMID: 31324481 [PubMed - as supplied by publisher]
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
Publication date: December 2019Source: Protein Expression and Purification, Volume 164Author(s): Elisabeth Graeber, Volodymyr M. KorkhovAbstractThe translocator protein TSPO is in an important diagnostic and therapeutic target in a range of pathologies, including neuroinflammation and cancer. Despite the availability of several structures of TSPO homologues, our understanding of the molecular determinants that govern high-affinity interactions of TSPO with its ligands is incomplete. Here, in order to decipher the key structural elements of TSPO responsible for interactions with its ligands, we designed a panel of chimeric ...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
Source: ClinicoEconomics and Outcomes Research - Category: Health Management Tags: ClinicoEconomics and Outcomes Research Source Type: research
Long time lurker here cGPA: 3.8 sGPA: 3.76 MCAT: 522 (129/130/131/132) Ethnicity: Hispanic (Puerto-Rican) State of Residence: NY, grew up in a poor, heavily Hispanic inner-city neighborhood. Parents never went to college, disadvantaged. ECs: -Clinical: Oncology floor volunteer (100 hr), surgical floor volunteer (60 hr), Psychiatric clinic volunteer (35 hr), stroke/spinal trauma unit volunteer (35 hr) -Nonclinical: 200+ hr in city-wide volunteer program that connects you with different... 3.8 GPA, 522 MCAT and URM/SES-Disadvantaged/First Gen... But a few red flags on app?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: What Are My Chances? WAMC Medical Source Type: forums
Source: ClinicoEconomics and Outcomes Research - Category: Health Management Tags: ClinicoEconomics and Outcomes Research Source Type: research
young female, known to have a metastatic breast cancer, since 5 years. In 2017, she developed secondary lesions in the brain with positive CSF. She receives 30Gy/10 fr whole brain radiation, with intra-thecal chemotherapy. A month ago, she developed gait disturbances with blurred speech an hemifacial paresia. Brain MRI showed a solitary secondary lesion, 1.5 cm involving the left middle cerebral peduncle with extensive edema. No signs of meningeal disease. Pet CT : NED outside the brain... SRS for BS lesion: what dose?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Radiation Oncology Source Type: forums
ConclusionsThe REAPSER study includes a cohort of patients with recent-onset PsA, before the disease course was modified by disease-modifying antirheumatic drugs prescribed in rheumatology departments. Exhaustive information collected in each visit is expected to be an important data source for future analysis.ResumenObjetivosDescribir la metodología del Registro Español de Artritis Psoriásica de reciente comienzo de la Sociedad Española de Reumatología (REAPSER), así como sus fortalezas y limitaciones. El objetivo principal del proyecto es identificar factores pronósticos d...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
Publication date: Available online 25 June 2019Source: The Journal of Molecular DiagnosticsAuthor(s): Paolo A. Ascierto, Carlo Bifulco, Giuseppe Palmieri, Solange Peters, Nikoletta SidiropoulosAn enduring goal of personalized medicine in cancer is the ability to identify patients who are likely to respond to specific therapies. Our increasing understanding of the biology and molecular signatures of individual tumor types has facilitated the identification of predictive biomarkers and has led to an increasing number of diagnostic tests to be performed, often as serial and distinct assays on limited tumor specimens. The biom...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
CONCLUSIONS: Thus, the Hawaii liver disease cluster is now best explained by various liver diseases rather than any DS, including OEP. PMID: 31320174 [PubMed]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
CONCLUSION: The management of HCC in clinical practice frequently deviates from the BCLC recommendations. Most of the curative therapy options, which have well-defined selection criteria, were allocated according to the recommendations, while the majority of the palliative therapy options were assigned to patients with tumor stages not aligned with the recommendations. The only parameter which is subjective in the algorithm, the performance status, is also the least respected. PMID: 31320173 [PubMed]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
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