Increasing Upstream Chromatin Long –Range Interactions May Favor Induction of Circular RNAs in LysoPC-Activated Human Aortic Endothelial Cells

Increasing Upstream Chromatin Long–Range Interactions May Favor Induction of Circular RNAs in LysoPC-Activated Human Aortic Endothelial Cells Angus Li1,2†, Yu Sun1†, Charles Drummer IV1, Yifan Lu1, Daohai Yu3, Yan Zhou4, Xinyuan Li1, Simone J. Pearson1, Candice Johnson1, Catherine Yu5, William Y. Yang1, Kevin Mastascusa1, Xiaohua Jiang1, Jianxin Sun6, Thomas Rogers7, Wenhui Hu1, Hong Wang1 and Xiaofeng Yang1,7* 1Center for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States 2Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, United States 3Department of Clinical Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States 4Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, Temple Health, Philadelphia, PA, United States 5Geisinger Commonwealth School of Medicine, Scranton, PA, United States 6Center for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Philadelphia University – Thomas Jefferson University, Philadelphia, PA, United States 7Center for Inflammation, Translational and Clinical Lung Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States Circular RNAs (circRNAs) are non-coding RNAs that form covalently closed continuous loops, and act as gene regulators in physiological and disease conditions. To test our hypothes...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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Authors: Zhylkaidarova A, Kaidarova D, Batyrbekov K, Shatkovskaya O, Begimbetova D Abstract We carried out an analysis of the total incidence of colon cancer throughout Kazakhstan. Retrospectively, according to the regional reports on endoscopic screening, the study showed an increase in the age-related incidence of colorectal cancer (CRC) cases from 2004-2008 to 2009-2014. The peak of morbidity in both periods was noted in the age category of>70 years. The indicators of the territorial distribution of CRC incidence make it possible to divide the regions into areas with low or high rates of CRC. Specific indicat...
Source: Clinical Endoscopy - Category: Gastroenterology Tags: Clin Endosc Source Type: research
Publication date: Available online 24 May 2020Source: Pharmacological ResearchAuthor(s): Teresa Di Desidero, Paola Orlandi, Daniela Gentile, Marta Banchi, Greta Alì, Claudia Kusmic, Paolo Armanetti, Ginelle J. Cayme, Luca Menichetti, Gabriella Fontanini, Giulio Francia, Guido Bocci
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 24 May 2020Source: Pharmacological ResearchAuthor(s): Jingjing Fan, Ziyuan Feng, Ning Chena
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 24 May 2020Source: Pharmacological ResearchAuthor(s): Li Wan, Zuofan Li, Tongtong Liu, Xuhui Chen, Qiaoqiao Xu, Wenlong Yao, Chuanhan Zhang, Yue Zhang
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
It’s been enough for a bit, isn’t it? For three months now, there has been little space in the world for any other kind of news. That is, news without the word ‘coronavirus’. But there was innovation, there is excitement and, well, even some weird (although useful!) inventions that appeared while the world has been in lockdown. So here’s an outlook on such news, all, promise, without that particular C-word. Hospitals have been facing great challenges recently. But they are on the verge of a new era that brings better care and more focus on the patient. This is a trend we have been talking a...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Artificial Intelligence Robotics Telemedicine & Smartphones Virtual Reality amazon diabetes smart contact lens Stanford University pharmacies Fitbit fitness trackers genome sequencing diabetes management genomic data 5G robot Source Type: blogs
Publication date: Available online 24 May 2020Source: Seminars in Cancer BiologyAuthor(s): Vaishali Aggarwal, Hardeep Singh Tuli, Mousumi Tania, Saumya Srivastava, Erin E. Ritzer, Anjana Pandey, Diwakar Aggarwal, Tushar Singh Barwal, Aklank Jain, Ginpreet Kaur, Katrin Sak, Mehmet Varol, Anupam Bishayee
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
The following describes the case of Miguel and a missed diagnosis in an undocumented minor.Miguel Estrada (all names changed to protect identity) was a 10-year-old boy of Central American origin initially seen at age 8 years in our university outpatient child psychiatry clinic. During the initial evaluation with a native Spanish-speaking provider, his mother, Mrs. Estrada, reported behavioral problems beginning at age 5 with diagnoses of attention-deficit/hyperactivity disorder and intellectual disability; a trauma history was denied. Over the subsequent 2 years, Miguel continued treatment in our outpatient service and lat...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Tags: Clinical perspectives Source Type: research
Publication date: Available online 25 May 2020Source: Food HydrocolloidsAuthor(s): Chao Ai, Hecheng Meng, Jiawei Lin, Tao Zhang, Xiaoming Guo
Source: Food Hydrocolloids - Category: Food Science Source Type: research
CONCLUSIONS LncRNA-ATB overexpression have promoting effects on inflammation, cell apoptosis and senescence in TGF-ß1 induced HK-2 cells via activating the TGFß/SMAD2/3 signaling pathway. LncRNA-ATB act as a key downstream mediator via activating the TGFß/SMAD2/3 signaling pathway and silencing LncRNA-ATB might be a new strategy for chronic kidney disease treatment. PMID: 32447340 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
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