Neutrophils Induce a Novel Chemokine Receptors Repertoire During Influenza Pneumonia

In conclusion, this study indicates an induction of CRs occurs upon neutrophil extravasation and activation into the pulmonary environment in a murine model of influenza pneumonia. These induced CRs could serve as potential therapeutic targets for alleviating neutrophil-induced lung pathology. Among all CRs, CXCR2 is most highly induced, and represents a promising target for therapy to reduce neutrophil recruitment to the area of inflammation. The functional properties of these individual chemokine receptors warrant further investigation to further understand how these induced CRs impact deleterious or beneficial effects of neutrophils as well as their roles in the context of influenza-induced acute lung injury. Ethics Statement IACUC, Oklahoma State University. Protocol No: VM-17-32. Author Contributions JMR, SP, HA, VC, and TN: conception and design of experiments; JMR, SP, HA, JWR, MM, and TN: acquisition and analysis of data; JRM, VC, and TN: critical review; TS: histopathology analysis. Funding This work was supported by the National Institute of General Medical Sciences of the National Institutes of Health (NIH) under Award Number P20GM103648, a grant from the Oklahoma Center for the Advancement of Science & Technology (OCAST) and a grant from Center for Veterinary Health Sciences, Oklahoma State University. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that ...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research