Neutrophils Induce a Novel Chemokine Receptors Repertoire During Influenza Pneumonia

Neutrophils Induce a Novel Chemokine Receptors Repertoire During Influenza Pneumonia Jennifer M. Rudd1, Sivasami Pulavendran1, Harshini K. Ashar1, Jerry W. Ritchey1, Timothy A. Snider1, Jerry R. Malayer1, Montelongo Marie1, Vincent T. K. Chow2 and Teluguakula Narasaraju1* 1Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, United States2Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore Exaggerated host innate immune responses have been implicated in severe influenza pneumonia. We have previously demonstrated that excessive neutrophils recruited during influenza infection drive pulmonary pathology through induction of neutrophil extracellular traps (NETs) and release of extracellular histones. Chemokine receptors (CRs) are essential in the recruitment and activation of leukocytes. Although neutrophils have been implicated in influenza pathogenesis, little is known about their phenotypic changes, including expression of CRs occurring in the infected -lung microenvironment. Here, we examined CC and CXC CRs detection in circulating as well as lung-recruited neutrophils during influenza infection in mice using flow cytometry analyses. Our studies revealed that lung-recruited neutrophils displayed induction of CRs, including CCR1, CCR2, CCR3, CCR5, CXCR1, CXCR3, and CXCR4, all of which were marginally induced in circulating neutro...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research

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Publication date: 1 October 2019Source: Personality and Individual Differences, Volume 148Author(s): Shuang Gao, Sander Thomaes, Wim Van Den Noortgate, Xiaochun Xie, Xiangkui Zhang, Suiping WangAbstractThe present study examined potential changes in narcissistic traits of Chinese youth from 2008 to 2017. A cross-temporal meta-analysis involving 29 independent samples (N = 14,795) found a downward temporal trend: Mean scores on the Narcissistic Personality Inventory and Narcissistic Personality Inventory for Chinese are significantly negatively associated with year of data collection, weighted by sample size (β =...
Source: Personality and Individual Differences - Category: Psychiatry & Psychology Source Type: research
Stats: state of residence: CA race: Asian (Chinese) undergrad: HYPSM major: Computer Science year: senior (taking 1 gap year) cGPA: 3.94 sGPA: 3.96 MCAT: 522 (130/131/129/132) ECs: research: my strongest EC, 2000+ hrs, 2pubs (1 first author, 1 fourth author), won some awards, researching full time during my gap year clinical volunteering: ~150hrs at free clinic, ~100hrs hrs at hospital nonclinical volunteering: started a nonprofit last year that I'll be growing in my gap year, ~200hrs... WAMC? + School List, MCAT: 522, GPA: 3.94, considering MD and MD-PhD
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: What Are My Chances? WAMC Medical Source Type: forums
ConclusionsThe results suggestthat the Calistar system offers similar efficacy in the treatment of anterior and both anterior and apical POP as compared to the Elevate. The use of anterior Calistar is associated with some additional benefits, i.e. SUI treatment in patients with concomitant anterior and both anterior and apical POP and SUI symptoms.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
ConclusionOur study highlights the fact that mobile genetic elements, such as plasmids, IS1216E, Tn554 and Tn558, may facilitate the horizontal transmission of optrA or poxtA.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionsOur work successfully identified the main active components in EXD, which could represent the efficacy of EXD on treating osteoporosis, and meanwhile, it also provided an effective strategy to investigate active ingredients from natural medicines, which might be helpful for drug development and application.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
In this study, we found that cofilin competes with tau for direct microtubule binding in vitro, in cells, and in vivo, which inhibits tau-induced microtubule assembly. Genetic reduction of cofilin mitigates tauopathy and synaptic defects in Tau-P301S mice and movement deficits in tau transgenic C. elegans. The pathogenic effects of cofilin are selectively mediated by activated cofilin, as active but not inactive cofilin selectively interacts with tubulin, destabilizes microtubules, and promotes tauopathy. These results therefore indicate that activated cofilin plays an essential intermediary role in neurotoxic signaling th...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 25 May 2019Source: Journal of Membrane ScienceAuthor(s): Xue Gao, Zhong-Kun Li, Jian Xue, Yong Qian, Li-Zhi Zhang, Jürgen Caro, Haihui WangAbstractHighly effective air filters are needed because of the increasing harm caused by air particulate matter pollution. Herein, two-dimensional titanium carbide Ti3C2Tx MXene nanosheets with active surface-terminating groups (O, OH and F) were used to modify the polyacrylonitrile (PAN) nanofiber filters to strengthen their interaction force with PM2.5. These forces were measured quantitatively through the force-distance curve-based AFM showing ...
Source: Journal of Membrane Science - Category: Materials Science Source Type: research
Publication date: Available online 25 May 2019Source: Journal of Materials Research and TechnologyAuthor(s): Hassan Shokry HassanAbstractNano-zirconium tungsto-vanadate cation exchange material was constructed in different morphological structures using sol–gel, hydrothermal and microwave techniques in presence of polymeric matrix as stabilizing agent. Polyvinyl alcohol was established as the optimum stabilizing agent. Influence of preparation parameters in presence of polyvinyl alcohol was examined as a function of ion exchange capacity and surface area for the prepared materials. The optimum reactant molar ratio wa...
Source: Journal of Materials Research and Technology - Category: Materials Science Source Type: research
Publication date: Available online 25 May 2019Source: Journal of Materials Research and TechnologyAuthor(s): Yassine Ennaciri, Hanan El Alaoui-Belghiti, Mohammed BettachAbstractThis paper proposes a very attractive process for K2SO4 production via the wet conversion of phosphogypsum (PG) and K2CO3. A parallel study of the conversion of two synthetic types of gypsum by K2SO4 was performed in order to compare their reactivity with that of PG.We remark that PG is more reactive and yields the desired results while commercial types of gypsum react slowly and generate unwanted secondary products. The factors affecting the PG con...
Source: Journal of Materials Research and Technology - Category: Materials Science Source Type: research
Publication date: Available online 25 May 2019Source: Journal of Materials Research and TechnologyAuthor(s): Adawiya J. Haider, Riyad Al- Anbari, Hiba M. Sami, Mohammed J. HaiderAbstractIn this work, synthesis of nickel oxide (NiO) using nickel acetate as a starting material by sol–gel method and then deposited as collide on glass slides to form thin layers of NiO by spin-coating technique with high photo-catalytic activity using as self cleaning coating. These films of NiO were annealed at different temperature 450 °C, 550 °C. The structural, morphological, spectral and optical properties of prepar...
Source: Journal of Materials Research and Technology - Category: Materials Science Source Type: research
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