Breath Therapeutics launches Ph3 trial for inhaled liposomal cyclosporine A therapy
Privately-held Breath Therapeutics said today that it kicked off a Phase III clinical program for its liposomal formulation of cyclosporine A for the treatment of bronchiolitis obliterans syndrome. The company’s primary drug candidate, L-CsA-i, is an inhaled therapy delivered via Pari Pharma‘s investigational eFlow nebulizer. Get the full story at our sister site, Drug Delivery Business News. The post Breath Therapeutics launches Ph3 trial for inhaled liposomal cyclosporine A therapy appeared first on MassDevice. (Source: Mass Device)
Source: Mass Device - March 26, 2019 Category: Medical Devices Authors: Sarah Faulkner Tags: Clinical Trials Drug-Device Combinations Pharmaceuticals Respiratory breaththerapeutics paripharma Source Type: news

Breath Therapeutics Announces Initiation of Global Phase 3 Trials for the Treatment of Bronchiolitis Obliterans Syndrome
Phase 3 BOSTON clinical studies will evaluate Liposomal Cyclosporine A for Inhalation (L‑CsA‑i), the first potential therapy for Bronchiolitis Obliterans Syndrome (BOS) BOS is a devastating lung disease with high mortality affecting over 30,... Biopharmaceuticals Breath Therapeutics, Bronchiolitis Obliterans Syndrome (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - March 26, 2019 Category: Pharmaceuticals Source Type: news

Bronchiolitis Hospitalization in Infancy Predicts More Admissions
Higher risk seen for future admissions by age 5; link strongest for asthma, wheezing admissions (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - March 13, 2019 Category: Respiratory Medicine Tags: Family Medicine, Infections, Nursing, Pediatrics, Pulmonology, Allergy, Emergency Medicine, Journal, Source Type: news

Bronchiolitis Hospitalization in Infancy Predicts More Admissions
WEDNESDAY, March 13, 2019 -- More than one in five infants with a bronchiolitis hospital admission will have a subsequent respiratory-related hospital admission by age 5 years, according to a study published online March 6 in the Archives of Disease... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 13, 2019 Category: Pharmaceuticals Source Type: news

Lung US for Diagnosing Pneumonia in Kids With Bronchiolitis Lung US for Diagnosing Pneumonia in Kids With Bronchiolitis
Lung ultrasound may be a safer and more cost-effective alternative to chest x-ray for detecting pneumonia in children with bronchiolitis.BMC Pulmonary Medicine (Source: Medscape Radiology Headlines)
Source: Medscape Radiology Headlines - February 13, 2019 Category: Radiology Tags: Pulmonary Medicine Journal Article Source Type: news

More Restrictive Definition Reduces UTI Prevalence in Bronchiolitis More Restrictive Definition Reduces UTI Prevalence in Bronchiolitis
The prevalence of urinary tract infection (UTI) in children with bronchiolitis declines when UTI is narrowly defined, according to a systematic review and meta-analysis.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 31, 2019 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Antibiotics Often Given Needlessly for Kids' Bronchiolitis (CME/CE)
(MedPage Today) -- No documented bacterial co-infection to justify use in 70% of cases (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - January 25, 2019 Category: Pediatrics Source Type: news

Inappropriate Antibiotic Prescribing for Acute Bronchiolitis Persists Inappropriate Antibiotic Prescribing for Acute Bronchiolitis Persists
Inappropriate prescribing of antibiotics for children with acute bronchiolitis persists in U.S. emergency departments (EDs), researchers report.Reuters Health Information (Source: Medscape Radiology Headlines)
Source: Medscape Radiology Headlines - January 22, 2019 Category: Radiology Tags: Infectious Diseases News Source Type: news

EDs Too Often Give Antibiotics for Infant Viral Lung Infections
(MedPage Today) -- One in four babies with bronchiolitis got antibiotics in national study (Source: MedPage Today Infectious Disease)
Source: MedPage Today Infectious Disease - January 18, 2019 Category: Infectious Diseases Source Type: news

Antibiotics Often Inappropriately Prescribed for Bronchiolitis in ED
In almost 70 percent of bronchiolitis cases, antibiotics prescribed with no concomitant infection (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - January 18, 2019 Category: Respiratory Medicine Tags: Family Medicine, Infections, Pediatrics, Pharmacy, Pulmonology, Emergency Medicine, Journal, Source Type: news

Antibiotics Often Inappropriately Prescribed for Bronchiolitis in ED
THURSDAY, Jan. 17, 2019 -- Most children younger than 2 years with bronchiolitis seen in U.S. emergency departments and prescribed antibiotics have no documented bacterial coinfection, according to a study published online Jan. 17 in the Journal of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 17, 2019 Category: Pharmaceuticals Source Type: news

Antibiotics Still Misused in Babies With Viral Lung Infections
THURSDAY, Jan. 17, 2019 -- U.S. emergency rooms routinely prescribe antibiotics to babies with the common viral lung infection bronchiolitis, counter to recommendations issued more than a decade ago, a new study finds. Bronchiolitis is the leading... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - January 17, 2019 Category: General Medicine Source Type: news

Antibiotics still routinely prescribed in the ER for infants with viral lung infections
(Pediatric Infectious Diseases Society) Despite recommendations first issued more than a decade ago, antibiotics are still routinely prescribed in US emergency rooms for infants with bronchiolitis, a common viral lung infection. Published in the Journal of the Pediatric Infectious Diseases Society, the findings highlight a concerning lag in translating evidence-based guidelines into clinical practice and underscore the need to continue educating health care providers and the public about appropriate antibiotic use. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - January 17, 2019 Category: Infectious Diseases Source Type: news

M2E Too!: Bronchiolitis Guidelines a Mismatch with Clinical Practice
No abstract available (Source: Emergency Medicine News)
Source: Emergency Medicine News - January 1, 2019 Category: Emergency Medicine Tags: M2E Too! Source Type: news

Nearly Half of Children Seen in ED for Bronchiolitis Get Radiography
Radiography use similar between patients admitted versus discharged from the ED (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - October 25, 2018 Category: Respiratory Medicine Tags: Infections, Pediatrics, Pulmonology, Radiology, Emergency Medicine, Journal, Source Type: news

Nearly Half of Children Seen in ED for Bronchiolitis Get Radiography
THURSDAY, Oct. 25, 2018 -- Despite guideline recommendations to the contrary, nearly half of children seen in the emergency department for bronchiolitis receive radiography, according to a research letter published online Oct. 16 in the Journal of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 25, 2018 Category: Pharmaceuticals Source Type: news

Children in ED Get Unnecessary Imaging for Bronchiolitis Children in ED Get Unnecessary Imaging for Bronchiolitis
Despite recommendations against radiography for suspected bronchiolitis, patients continued to receive unnecessary imaging, a study found.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 16, 2018 Category: Consumer Health News Tags: Emergency Medicine News Source Type: news

Nine ways research could save the NHS money
This highlight provides nine treatments and initiatives that are cost effective for the NHS including weight loss surgery, misaligned shoulder fractures, rotavirus vaccine, public health interventions, oxygen levels for acute bronchiolitis in children, routine replacement of intravenous cannulae, behavioural activation, oral surgery in primary care, and uterine polyps. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 16, 2018 Category: Consumer Health News Source Type: news

Factors Predictive of Escalated Care in Infant Bronchiolitis ID'd
MONDAY, Sept. 17, 2018 -- Variables have been identified that predict escalated care for infants with bronchiolitis, according to a study published in the September issue of Pediatrics. Gabrielle Freire, M.D., from the University of Toronto, and... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 17, 2018 Category: Pharmaceuticals Source Type: news

FDA: Don't Use Azithromycin for Lung Condition in Cancer Patients FDA: Don't Use Azithromycin for Lung Condition in Cancer Patients
The FDA warns of an increased risk for relapse of hematologic malignancy and for death when azithromycin is used to prevent bronchiolitis obliterans syndrome in hematopoietic stem cell transplant patients.News Alerts (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 3, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Alert Source Type: news

Even the Thinnest Salami Contains Some Meat Even the Thinnest Salami Contains Some Meat
This editorial comments on a recent study regarding differences in the utilization of albuterol for infants with bronchiolitis.Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 28, 2018 Category: Consumer Health News Tags: Emergency Medicine Journal Article Source Type: news

High-Flow Oxygen to Treat Infants With Bronchiolitis High-Flow Oxygen to Treat Infants With Bronchiolitis
Dr Patel reviews a study that compares the outcomes of infants with bronchiolitis treated outside an ICU who received high-flow oxygen therapy versus those who received standard oxygen therapy.Medscape Emergency Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 12, 2018 Category: Consumer Health News Tags: Emergency Medicine Viewpoint Source Type: news

Four-month-old baby boy is fighting for his life after being diagnosed with a rare cancer
Four-month-old Roman Hansen, from South Shields, was initially with  bronchiolitis until tests showed a collapsed lung, leading to him having much of the organ removed. (Source: the Mail online | Health)
Source: the Mail online | Health - June 12, 2018 Category: Consumer Health News Source Type: news

Does High-Flow Cannula Oxygen Improve Bronchiolitis Outcomes? Does High-Flow Cannula Oxygen Improve Bronchiolitis Outcomes?
A study tested high-flow versus standard cannula in the delivery of oxygen to infants with bronchiolitis.Medscape Pediatrics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 6, 2018 Category: Consumer Health News Tags: Pediatrics Viewpoint Source Type: news

Initiative Cuts Overuse of Tests, Treatments for Bronchiolitis
Reductions in ordering of chest radiographs, respiratory viral testing, bronchodilators (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - May 11, 2018 Category: Respiratory Medicine Tags: Family Medicine, Infections, Nursing, Pediatrics, Pulmonology, Radiology, Emergency Medicine, Journal, Source Type: news

Initiative Cuts Overuse of Tests, Treatments for Bronchiolitis
FRIDAY, May 11, 2018 -- A multidisciplinary improvement initiative can reduce overuse of interventions for bronchiolitis, according to a study published online May 11 in Pediatrics. In an effort to reduce overuse of interventions for children with a... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 11, 2018 Category: Pharmaceuticals Source Type: news

What Causes Hyponatremia?
Discussion Normal kidneys regulate water balance to maintain a plasma osmolality of 275-290 mOsm/kg normally. Thirst and arginine vasopressin or antidiuretic hormone (ADH) are the primary regulators of plasma osmolality. ADH is made in the hypothalamus and released by the posterior pituitary gland. ADH acts on the kidney’s distal collecting duct to increase water reabsorption. ADH is appropriately released in hypovolemic states, such as dehydration caused by gastroenteritis. ADH has an ~10 minute half-life and therefore can respond to rapid changes in volume status. Sodium balance is regulated by aldosterone (as part...
Source: PediatricEducation.org - April 23, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Spikes in air pollution can heighten risk of chest infections, research suggests
Study of PM2.5 levels in Utah suggests increase in diagnoses of viral infections such as bronchitis follows even brief upticks in pollutionEven short-term increases in air pollution are linked to a higher risk of developing viral chest infections that turn into conditions such as bronchiolitis, new research suggests.The study, carried out by scientists in the US, looked at levels of tiny particles in the air known asPM2.5s across eight locations along the Wasatch Front in Utah, including Salt Lake City. This area features a string of towns and is home the majority of the state ’s population and, due to various factor...
Source: Guardian Unlimited Science - April 13, 2018 Category: Science Authors: Nicola Davis Tags: Pollution Science Environment Health Society US news UK news World news Bronchitis Source Type: news

You Asked: What ’s the Healthiest Way to Make Popcorn?
If you’ve ever wondered exactly what happens when a popcorn kernel pops, well, scientific research has the answer. An un-popped corn kernel is a drop of water surrounding by soft starch and encased in a hull. Heat up that kernel, and the water molecules locked inside will expand until the pressure and heat cause the starch to inflate and explode, bursting the hull and turning the kernel inside-out. What you have left after this popping occurs is a filling, low-calorie, whole-grain food packed with fiber. “Popcorn is an extremely nutritious snack compared to most,” says Joe Vinson, a professor of chemistry...
Source: TIME: Health - March 28, 2018 Category: Consumer Health News Authors: Markham Heid Tags: Uncategorized Diet/Nutrition Source Type: news

Genetic factors for most common disease in the first year of life are identified
(Funda ç ã o de Amparo à Pesquisa do Estado de S ã o Paulo) The acute viral bronchiolitis is the worldwide leading cause of hospitalization during this period. A study crosses data from patients' genetic variations with the disease's different viruses and their respective set of symptoms, paving the way for future developments by precision medicine. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 26, 2018 Category: International Medicine & Public Health Source Type: news

Orthotics and Heel Pain; Bacteria and Cancer: It's PodMed Double T! (with audio)
(MedPage Today) -- This week's topics include infants with bronchiolitis, orthotics for heel pain, behavioral therapy in dementia, and H. pylori infection in early gastric cancer (Source: MedPage Today Psychiatry)
Source: MedPage Today Psychiatry - March 24, 2018 Category: Psychiatry Source Type: news

High-Flow Oxygen Therapy Improves Outcomes in Infant Brochiolitis High-Flow Oxygen Therapy Improves Outcomes in Infant Brochiolitis
High-flow oxygen therapy given by nasal cannula to infants with bronchiolitis - a treatment that adds heat, humidity and extra pressure to the oxygen - can cut odds of treatment failure by nearly half compared to standard-flow therapy, according to a new pragmatic study in Australia.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 23, 2018 Category: Consumer Health News Tags: Pediatrics News Source Type: news

High-Flow Oxygen Therapy Improves Outcomes in Infant Bronchiolitis High-Flow Oxygen Therapy Improves Outcomes in Infant Bronchiolitis
High-flow oxygen therapy given by nasal cannula to infants with bronchiolitis - a treatment that adds heat, humidity and extra pressure to the oxygen - can cut odds of treatment failure by nearly half compared to standard-flow therapy, according to a new pragmatic study in Australia.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - March 23, 2018 Category: Intensive Care Tags: Pediatrics News Source Type: news

High-Flow Oxygen Improves Infant Bronchiolitis Outcomes
(MedPage Today) -- Reduced need for escalation of care (Source: MedPage Today Infectious Disease)
Source: MedPage Today Infectious Disease - March 22, 2018 Category: Infectious Diseases Source Type: news

High - Flow O2 Therapy Feasible for Infants With Bronchiolitis
Tied to lower rate of care escalation than standard oxygen therapy in infants treated outside ICU (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - March 22, 2018 Category: Respiratory Medicine Tags: Family Medicine, Pediatrics, Pulmonology, Emergency Medicine, Journal, Source Type: news

Zimbabwe:Bronchiolitis Cases Continue to Increase in Harare
[The Herald] Harare continues to record an increased number of bronchiolitis, with cases now being recorded at other health facilities such as Parirenyatwa Group of Hospitals and Chitungwiza Central Hospital, Health and Child Care Minister Dr David Parirenyatwa has said. (Source: AllAfrica News: Pregnancy and Childbirth)
Source: AllAfrica News: Pregnancy and Childbirth - March 6, 2018 Category: OBGYN Source Type: news

Reducing Antibiotic Use in Respiratory Syncytial Virus: A Quality Improvement Approach to Antimicrobial Stewardship
This research article examines how increased incidence of multidrug-resistant organisms is associated with increased morbidity, mortality, hospital length of stay, and cost. Estimates show that up to 50% of antimicrobial use is inappropriate. This initiative focuses on inappropriate use of antibiotics in respiratory syncytial virus (RSV) infections. This virus is the most common cause of bronchiolitis during childhood. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 25, 2018 Category: Consumer Health News Source Type: news

Finding the root cause of bronchiolitis symptoms
(Children's National Health System) 'By treating all bronchiolitis patients with a single agent, we could be comparing apples with oranges,' says Robert J. Freishtat, M.D., M.P.H., chief of emergency medicine at Children's National Health System. The necessary treatment may differ, depending on the underlying cause: Respiratory syncytial virus, rhinovirus or another virus. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 24, 2018 Category: International Medicine & Public Health Source Type: news

What is DIOS?
Discussion Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane receptor (CFTR). It is found in the epithelium of the bronchi, intestine, pancreatic duct and biliary tree. It regulates chloride, bicarbonate and water secretion. The heterozygous state helps prevent against secretory diarrhea, but the homozygous state causes thickened secretions in the hollow tubes of the lungs and digestive tract. There are multiple mutations (> 2000) which have been currently classified into classes depending on their protein production and activity. CF patients generally are l...
Source: PediatricEducation.org - December 18, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Mother issues anxious bronchiolitis warning to parents
Beth Foster, 21, from Stourbridge in the West Midlands, posted a gut-wrenching photo of her baby girl on Facebook along with a strong message to other young parents. (Source: the Mail online | Health)
Source: the Mail online | Health - December 11, 2017 Category: Consumer Health News Source Type: news

Hospitals Vary Widely in Management of Infant Bronchiolitis Hospitals Vary Widely in Management of Infant Bronchiolitis
According to a new study, almost one third of infants hospitalized with bronchiolitis receive no evidence-based supportive therapies.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 28, 2017 Category: Consumer Health News Tags: Pulmonary Medicine News Source Type: news

Popcorn Lung (Bronchiolitis Obliterans Symptoms, Causes, Life Expectancy
Title: Popcorn Lung (Bronchiolitis Obliterans Symptoms, Causes, Life ExpectancyCategory: Diseases and ConditionsCreated: 11/28/2017 12:00:00 AMLast Editorial Review: 11/28/2017 12:00:00 AM (Source: MedicineNet Lungs General)
Source: MedicineNet Lungs General - November 28, 2017 Category: Respiratory Medicine Source Type: news

World Antibiotic Awareness Week
Professor Dame Sally Davies, England's Chief Medical Officer, recently warned that the world could face a  " post-antibiotic apocalypse.” She urged that, unless action is taken to halt the practices that have allowed antibiotic resistance to spread and ways are found to develop new types of antibiotics, we could return to the days when simple wounds, infections or routine operations, are life-threatening. To mark   World Antibiotic Awareness Week, 12th-18th November 2018,  we are highlighting Cochrane  evidence which supports decision-making in the appropriate use of antibiotics.&nb...
Source: Cochrane News and Events - November 16, 2017 Category: Information Technology Authors: Muriah Umoquit Source Type: news

World Antibiotic Awareness Week
Professor Dame Sally Davies, England's Chief Medical Officer, recently warned that the world could face a  " post-antibiotic apocalypse.” She urged that, unless action is taken to halt the practices that have allowed antibiotic resistance to spread and ways are found to develop new types of antibiotics, we could return to the days when simple wounds, infections or routine operations, are life-threatening. To mark   World Antibiotic Awareness Week, 13th-19th November,  we are highlighting Cochrane  evidence which supports decision-making in the appropriate use of antibiotics. Pr...
Source: Cochrane News and Events - November 13, 2017 Category: Information Technology Authors: Muriah Umoquit Source Type: news

Is Nebulized Hypertonic Saline More Effective for Bronchiolitis? Is Nebulized Hypertonic Saline More Effective for Bronchiolitis?
A multisite pediatric emergency department study compared hypertonic and normal saline nebulizer treatments for bronchiolitis.Medscape Pediatrics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 10, 2017 Category: Consumer Health News Tags: Pediatrics Viewpoint Source Type: news

Dipstick test children ’s urine before prescribing antibiotics
Test in infants and children 3 months or older but younger than 3 years with suspected UTI Related items fromOnMedica GPs need support to convince public to stop expecting antibiotics Feedback better than education for cutting inappropriate antibiotic prescribing Children with asthma prescribed ‘unnecessary antibiotics’ GPs welcome NICE advice on bronchiolitis in children (Source: OnMedica Latest News)
Source: OnMedica Latest News - September 28, 2017 Category: UK Health Source Type: news

Antibiotics not recommended for acute otitis, says NICE
RCGP supports decision advised in draft guidance Related items fromOnMedica No evidence to back mantra that patients need to complete antibiotic course Ear disorders Managing minor illness in primary care – external ear complaints Acute otitis media GPs welcome NICE advice on bronchiolitis in children (Source: OnMedica Latest News)
Source: OnMedica Latest News - September 22, 2017 Category: UK Health Source Type: news

Skip Pulse Oximetry in Bronchiolitis, Experts Say Skip Pulse Oximetry in Bronchiolitis, Experts Say
Pulse oximetry in young children with bronchiolitis may lead to overdiagnosis of hypoxemia, increased hospital admissions, and longer length of stay, experts say.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 17, 2017 Category: Consumer Health News Tags: Pediatrics News Source Type: news

What are Indications for Continuous Positive Airway Pressure (CPAP)?
DiscussionObstructive sleep apnea syndrome (OSAS) is defined as a “disorder of breathing during sleep characterized by prolonged partial upper airway obstruction and/or intermittent complete obstruction (obstructive apnea) that disrupts normal ventilation during sleep and normal sleep patterns.” It is different than primary snoring which is snoring without apnea, sleep arousals, or problems with gas exchange. OSAS symptoms include snoring (often with snorts, gasps or pauses), disturbed sleep (often frequent arousals) and daytime neurobehavioral problems. Sleepiness during the day can occur but is less common in...
Source: PediatricEducation.org - June 12, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Delayed presentation of button battery ingestion: a devastating complication - Chessman R, Verkerk M, Hewitt R, Eze N.
A 12-month-old child presented with a prolonged history of fever, cough and difficulty breathing, which was initially treated as bronchiolitis. She was discharged but presented again to Accident and Emergency department 4 days later with worsening symptom.... (Source: SafetyLit)
Source: SafetyLit - April 11, 2017 Category: Global & Universal Tags: Age: Infants and Children Source Type: news