Bovine Milk Extracellular Vesicles (EVs) Modification Elicits Skeletal Muscle Growth in Rats

Conclusion Sonication is a newer approach to understanding how EVs obtained through the diet may affect the physiology of an organism. Notably, the changes observed in gastrocnemius fCSA, transcriptome, miRNA, and oxidative stress markers in rats suggest that modulating bovine milk-derived EVs may affect skeletal muscle physiology. Ethics Statement All experimental procedures were approved by Auburn University’s Institutional Animal Care and Use Committee (IACUC, protocol #2017-3081). Author Contributions AK, MDR, KY, and JZ contributed conception and design of the study. HP, CM, PM, MAR, CH, YZ, PR, and IV contributed to data collection, writing, and editing. JZ, AF, and JM contributed to the investigation, methodology, and editing. HP, CM, MDR, and AK wrote the first draft of the manuscript. All authors contributed to manuscript revision, read and approved the submitted version. Funding Funding for this study was provided through the Auburn University Intramural grant Program awarded to AK, MDR, and KY. Also, the development of the diets was supported by NIFA 2015-67017-23181 and 2016-67001-25301, NIH 1P20GM104320, Bill and Melinda Gates Foundation, Gerber Foundation, and PureTech Health, Inc., awarded to JZ. Conflict of Interest Statement JZ serves as a consultant for PureTech Health, Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict...
Source: Frontiers in Physiology - Category: Physiology Source Type: research