Twist of fate: What happens when a top Parkinson ’s researcher gets the disease?

SEVERAL YEARS AGO , Tim Greenamyre, a neuroscientist and physician who directs the Pittsburgh Institute for Neurodegenerative Diseases at the University of Pittsburgh (Pitt), began to notice unsettling symptoms in his own body. He couldn’t smell things. He was constipated. He was shouting and kicking in his sleep. His left arm didn’t swing when he walked. In July 2021, Greenamyre turned to a neurologist colleague to confirm the diagnosis he already suspected. He had Parkinson’s disease, an illness he has devoted himself to treating and trying to cure. Over the course of his long and productive career, the 67-year-old has not only won the admiration of his patients and clinical colleagues, but also developed a widely used animal model of Parkinson’s and contributed key insights into environmental triggers. That work exposed him to chemicals that induce the disease in rodents, a possible factor in his own illness. “The irony is obvious,” says Greenamyre, a shy man with a dry sense of humor and a penchant for practical jokes who, to the unpracticed eye, shows few if any signs of the disease. (For now, he says, medication is helping.) For colleagues, the news has been shocking and heartbreaking. “I was so deeply affected I could not respond right away,” says Laurie Sanders, a neuroscientist who studies Parkinson’s at Duke University School of Medicine and is a former Greenamyre postdoc. “All I really honestly wanted to do was just drive ...
Source: Science of Aging Knowledge Environment - Category: Geriatrics Source Type: research