How Good is Cholecystectomy For Biliary Dyskinesia in Pediatric Patients?
Discussion Biliary disease includes gallstones, cholecystitis (inflammation of the gallbladder), cholangiopathy and cholangitis (pathology of the bile ducts), biliary dyskinesia, gangrene, and cancer. Some are often overlapping as gallstones often contributing to cholecystitis and cholangitis. Biliary dyskinesia (BD) is well-recognized in adults. Adult criteria include: “abdominal pain located in the epigastrium and/or right upper quadrant along with; buildup of pain to a steady level and lasting 30 minutes or longer, pain occurring at different intervals and not daily, severe enough to interrupt activities or lead t...
Source: PediatricEducation.org - January 30, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Janssen Announces Unblinding of Phase 3 CARTITUDE-4 Study of CARVYKTI ® (cilta-cel) as Primary Endpoint Met in Treatment of Patients with Relapsed and Refractory Multiple Myeloma
RARITAN, New Jersey, January 27, 2023 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the Phase 3 CARTITUDE-4 study evaluating CARVYKTI® (ciltacabtagene autoleucel; cilta-cel) versus pomalidomide, bortezomib, and dexamethasone (PVd) or daratumumab, pomalidomide, and dexamethasone (DPd) for the treatment of patients with relapsed and lenalidomide-refractory multiple myeloma met its primary endpoint of significant improvement in progression-free survival (PFS) at the first pre-specified interim analysis. As a result of meeting the primary endpoint, the Independent Data Monitoring Commi...
Source: Johnson and Johnson - January 27, 2023 Category: Pharmaceuticals Tags: Latest News Source Type: news

Varicose veins 'rarely seen' in parts of the world that follow simple dietary rule
Studies have found a "significant association" between the formation of varicose veins and chronic constipation. (Source: Daily Express - Health)
Source: Daily Express - Health - January 26, 2023 Category: Consumer Health News Source Type: news

From back pain to constipation: Tell-tale symptoms of cervical cancer REVEALED
To mark cervical cancer awareness week, MailOnline looked at the well-known, and less-so, symptoms of cervical cancer to watch out for. (Source: the Mail online | Health)
Source: the Mail online | Health - January 24, 2023 Category: Consumer Health News Source Type: news

How to prevent and treat chronic constipation
Increasing fiber intake, drinking enough fluids, paying attention to timing, adopting the right posture and exercising can help relieve constipation. (Source: Washington Post: To Your Health)
Source: Washington Post: To Your Health - January 23, 2023 Category: Consumer Health News Authors: Hallie Levine Source Type: news

What Are Common Dietary Fermentable Carbohydrates?
Discussion Parents may often come to the pediatrician for concerns about crying and colic, increased belching, abdominal distention, increased flatulence, abdominal pain or stool changes. They complain of increased “gassiness,” which could mean any or a combination of these problems, or something different that they believe is referred to the abdomen. In newborns parents’ intolerance for crying and normal changes in the abdomen (e.g. appearing larger or smaller) may have them complain of “gassiness” but they do not mean actual belching or flatulence. In older children, parents may state that t...
Source: PediatricEducation.org - January 16, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

What Causes Bloating —and What to Do About It
Bloating is an uncomfortable feeling of fullness or pressure in the abdomen. Like an overinflated balloon, a bloated belly can feel packed with air, and in some cases may be visibly enlarged or distended. Bloating is a common issue. By some estimates, up to 30% of Americans experience it from time to time. In a majority of cases, the sensation is temporary and tolerable. It may not be pleasant, but on its own it’s usually not cause for serious concern. However, bloating can also be a symptom of an underlying gastrointestinal problem or disorder, including some issues that warrant a medical provider’s urgent att...
Source: TIME: Health - January 4, 2023 Category: Consumer Health News Authors: Markham Heid Tags: Uncategorized Gut health healthscienceclimate Source Type: news

Kiwifruit Found Effective for Constipation Kiwifruit Found Effective for Constipation
The fruit beat psyllium in treating functional constipation and matched it in treating constipation-predominant irritable bowel syndrome.Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - December 29, 2022 Category: Gastroenterology Tags: Gastroenterology News Source Type: news

‘Physical activity’ is the best method to treat constipation says BNF
After a meal of heavy and rich food, there may be some people who feel a little constipated. Getting up and about could be the best cure for feeling blocked. (Source: Daily Express - Health)
Source: Daily Express - Health - December 26, 2022 Category: Consumer Health News Source Type: news

Janssen Presents Efficacy and Subgroup Analyses from MAIA Study Showing Long-Term Results of DARZALEX ® (daratumumab)-based Regimen in Newly Diagnosed, Transplant-Ineligible Multiple Myeloma
NEW ORLEANS, December 12, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new analyses from the Phase 3 MAIA study of DARZALEX® (daratumumab) in combination with lenalidomide and dexamethasone (D-Rd), evaluating progression-free survival (PFS), minimal residual disease (MRD) negativity and overall response rate (ORR) at a median follow-up of 64.5 months, and overall survival (OS) at a median follow-up of 73.6 months in newly diagnosed, transplant-ineligible (TIE) patients with multiple myeloma, regardless of patients’ age and across clinically important subgroups, as well as health...
Source: Johnson and Johnson - December 12, 2022 Category: Pharmaceuticals Tags: Latest News Source Type: news

Janssen Presents First Data from MajesTEC-2 Trial of TECVAYLI ™ (teclistamab-cqyv) in Combination with DARZALEX FASPRO® (daratumumab and hyaluronidase-fihj) and Lenalidomide in Relapsed or Refractory Multiple Myeloma
NEW ORLEANS, December 10, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today new results from a cohort of the Phase 1b MajesTEC-2 study of TECVAYLI™ (teclistamab-cqyv), a first-in-class, BCMAxCD3 bispecific T-cell engager antibody, in combination with DARZALEX FASPRO® (daratumumab and hyaluronidase-fihj) and lenalidomide. According to the results, the immune-based triplet therapy regimen had a manageable safety profile with no unexpected safety signals observed. A very good partial response (VGPR) or better was achieved by 90.3 percent of patients with relapsed or refractory multiple ...
Source: Johnson and Johnson - December 10, 2022 Category: Pharmaceuticals Tags: Latest News Source Type: news

How is Endometriosis Diagnosed?
Discussion Endometriosis is classically defined as endometrial tissue occurring outside the uterine lining. It is a common cause of chronic pelvic pain and dysmenorrhea in adolescents. It can present differently in adolescents than adult women and usually can appear like many other common problems such as chronic constipation or gastrointestinal dysmotility. It is estimated that ~25-38% of adolescents with chronic pelvic pain have endometriosis. Use of clinical criteria versus laparoscopic documentation of disease makes the epidemiology of this problem more challenging. The cause is not wholly agreed upon but many believe ...
Source: PediatricEducation.org - November 28, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

‘Alternating' bouts of constipation and diarrhoea could signal three major diseases
Changes in bowel movements can reveal a lot about a person's health. (Source: Daily Express - Health)
Source: Daily Express - Health - November 13, 2022 Category: Consumer Health News Source Type: news

Novel Drug Eases Parkinson's-Related Constipation in Early Trial Novel Drug Eases Parkinson's-Related Constipation in Early Trial
Researchers say the drug is safe and ' rapidly normalized bowel function. 'MDedge News (Source: Medscape Internal Medicine Headlines)
Source: Medscape Internal Medicine Headlines - November 8, 2022 Category: Internal Medicine Tags: Internal Medicine News Source Type: news