Ironwood begins Phase III trial of linaclotide 72mcg in adults with chronic idiopathic constipation
US-based Ironwood Pharmaceuticals has started a Phase III clinical trial in the US evaluating once-daily linaclotide 72mcg capsule in adults suffering from chronic idiopathic constipation (CIC). (Source: Drug Development Technology)
Source: Drug Development Technology - November 5, 2014 Category: Pharmaceuticals Source Type: news

Rhythm reports positive results from relamorelin Phase II trial to treat chronic constipation
US-based biopharmaceutical firm Rhythm has reported positive results from a Phase IIa clinical trial of relamorelin (RM-131) in patients with chronic constipation. (Source: Drug Development Technology)
Source: Drug Development Technology - October 27, 2014 Category: Pharmaceuticals Source Type: news

Children's Hospital Los Angeles receives $1 million grant from Autism Speaks
(Children's Hospital Los Angeles) Pat Levitt, PhD, Simms/Mann Chair in Developmental Neurogenetics at Children's Hospital Los Angeles, has received a grant of nearly $1 million from Autism Speaks, the world's leading autism science and advocacy organization. Funding will support research into the treatment of chronic constipation to improve behavioral symptoms associated with autism spectrum disorder. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 24, 2014 Category: Global & Universal Source Type: news

Constipation Eased by New Ghrelin Analog
(MedPage Today) -- Relamorelin hastened bowel transit time in a phase II trial. (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - October 22, 2014 Category: Gastroenterology Source Type: news

Refocus bowel health to cut unnecessary admissions and spending
Constipation costs the NHS £59m a year (Source: HSJ)
Source: HSJ - October 20, 2014 Category: UK Health Source Type: news

What Factors Decide Urolithiasis Treatment?
Discussion Although pediatric uroliathiasis is relatively rare, there has been an increasing number of children evaluated for renal stones over time. For an overview of uroliathiasis click here. Renal colic classically has paroxysmal pain that is severe, radiates toward the groin and the patient is not able to find a comfortable position. They may also have irritability, nausea, emesis, increased urinary frequency, dysuria and hematuria. 85-90% of patients will have macro- or microscopic hematuria but up to 15% of patients with urolithiasis will not have hematuria. Clinical differential diagnosis includes but is not limit...
Source: PediatricEducation.org - October 13, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Laxative Type Might Influence Colon Cancer Risk
Fiber-based formulations seem to lower chances for the disease, non-fiber products seem to raise them Source: HealthDay Related MedlinePlus Pages: Colorectal Cancer, Constipation (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - October 8, 2014 Category: Consumer Health News Source Type: news

Potty training before age two linked to increased risk of later wetting problems
Children who start toilet training before age 2 have a three times higher risk of developing daytime wetting problems later, according to new research. Additionally, in the current study, early trainers were three times more likely to complain of constipation than normal trainers. "Almost all of the children who had wetting also had constipation," the authors noted. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - October 7, 2014 Category: Science Source Type: news

Ardelyx bowel drug succeeds in mid-stage trial
(Reuters) - Ardelyx Inc said its experimental drug to treat constipation-related irritable bowel syndrome achieved the main goal of increasing bowel movement compared with a placebo in a mid-stage study involving 371 patients. (Source: Reuters: Health)
Source: Reuters: Health - October 1, 2014 Category: Consumer Health News Tags: healthNews Source Type: news

Ardelyx irritable bowel syndrome drug succeeds in mid-stage trial
(Reuters) - Ardelyx Inc said its experimental drug to treat constipation-related irritable bowel syndrome achieved the main goal of increasing bowel movement compared to a placebo in a mid-stage study involving 371 patients. (Source: Reuters: Health)
Source: Reuters: Health - October 1, 2014 Category: Consumer Health News Tags: healthNews Source Type: news

FDA Okays Methylnaltrexone (Relistor) for Opioid ConstipationFDA Okays Methylnaltrexone (Relistor) for Opioid Constipation
The makers of Relistor announced approval of an expanded indication for this previously approved drug in treatment of opioid-induced constipation. FDA Approvals (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 1, 2014 Category: Consumer Health News Tags: Neurology & Neurosurgery News Alert Source Type: news

Hysterectomy?…..Yes please! – Francesca’s Story
Sourced from The Hysterectomy Association: Hysterectomy Association - Hysterectomy Association - hysterectomy, menopause and hormone replacement therapy (hrt) information and support for women. Hi, thank you for taking the time to read my story Where do I begin?? I’m 31 and suffering with a very large submucousal and pedunculated fibroid, growing from the back wall of my uterus that is as large wide as it is long. My extended womb presses on my bladder and bowels, causing chronic constipation and regular UTI’s + all of the other horrid symptoms I won’t mention. The bleeding has always been my biggest pro...
Source: The Hysterectomy Association - September 30, 2014 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Your Stories fibroids myomectomy total abdominal hysterectomy Source Type: news

CHMP Backs Naloxegol (Moventig) in Opioid-Induced ConstipationCHMP Backs Naloxegol (Moventig) in Opioid-Induced Constipation
On the heels of its US approval, European regulators have recommended approval of naloxegol for opioid-induced constipation in adults who fail laxatives. International Approvals (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - September 27, 2014 Category: Neurology Tags: Neurology & Neurosurgery News Alert Source Type: news

Stephen Sutton's cancer signs ignored, says his mother
Stephen Sutton's mother Jane, 50, described how their pleas for cancer tests were ignored and doctors insisted for six months he was constipated, despite warning symptoms (Source: Telegraph Health)
Source: Telegraph Health - September 22, 2014 Category: Consumer Health News Source Type: news

AstraZeneca’s Movantik receives FDA approval to treat OIC
AstraZeneca has received approval from the US Food and Drug Administration (FDA) for its Movantik (naloxegol) tablets C-II to treat opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain. (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - September 17, 2014 Category: Pharmaceuticals Source Type: news

FDA Approves Movantik for Pain-med Constipation
Movantik is an oral treatment for opioid-induced constipation in adults with chronic non-cancer pain (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - September 17, 2014 Category: Pharmaceuticals Source Type: news

Movantik Approved for Constipation From Opioids
Title: Movantik Approved for Constipation From OpioidsCategory: Health NewsCreated: 9/16/2014 2:36:00 PMLast Editorial Review: 9/17/2014 12:00:00 AM (Source: MedicineNet Crohn's Disease General)
Source: MedicineNet Crohn's Disease General - September 17, 2014 Category: Gastroenterology Source Type: news

FDA Okays Naloxegol (Movantik) in Opioid-Induced ConstipationFDA Okays Naloxegol (Movantik) in Opioid-Induced Constipation
Approval comes following results of 2 studies showing the drug is safe and effective. FDA Approvals (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - September 17, 2014 Category: Neurology Tags: Neurology & Neurosurgery News Alert Source Type: news

FDA Approves New Drug to Alleviate Opioid-Induced Constipation (FREE)
By Kristin J. Kelley Edited by David G. Fairchild, MD, MPH, and Lorenzo Di Francesco, MD, FACP, FHM The FDA has approved naloxegol (Movantik) to decrease the … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - September 17, 2014 Category: Primary Care Source Type: news

Drug for Opioid Constipation Wins OK
(MedPage Today) -- Patients experiencing opioid-induced constipation will have another treatment option, thanks to the FDA's approval of naloxegol (Movantik) on Tuesday. (Source: MedPage Today Psychiatry)
Source: MedPage Today Psychiatry - September 16, 2014 Category: Psychiatry Source Type: news

FDA approves AstraZeneca, Nektar constipation drug
(Reuters) - The U.S. Food and Drug Administration approved an oral therapy to treat opioid-induced constipation developed by Nektar Therapeutics and AstraZeneca Plc. (Source: Reuters: Health)
Source: Reuters: Health - September 16, 2014 Category: Consumer Health News Tags: healthNews Source Type: news

FDA approves Movantik for opioid-induced constipation
The U.S. Food and Drug Administration today approved Movantik (naloxegol), an oral treatment for opioid-induced constipation in adults with chronic non-cancer pain. (Source: Food and Drug Administration)
Source: Food and Drug Administration - September 16, 2014 Category: American Health Source Type: news

Why figs are fantastic for us
(NaturalNews) Figs are good for relieving constipation, lowering cholesterol, lowering blood pressure, weight loss, preventing osteoporosis and heart disease, promoting tanning, and they are a good source of prebiotics. Figs are high in calcium, potassium, phosphorus, and iron.Natural... (Source: NaturalNews.com)
Source: NaturalNews.com - September 15, 2014 Category: Consumer Health News Source Type: news

Few mild-to-moderate Parkinson's disease patients suffer from malnutrition, yet almost one third are at risk
Many factors could lead to poor nutrition in Parkinson's disease (PD) patients, including motor difficulties with swallowing and chewing (dysphagia), cutting, and bringing food to the mouth. PD-related constipation and depression can also dampen a patient's appetite and change dietary habits. A new report says that some of these patients are therefore at risk of malnutrition. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - September 11, 2014 Category: Science Source Type: news

Constipation and My Intestines after TAH/BSO – Gretchen’s Story
Sourced from The Hysterectomy Association: Hysterectomy Association - Hysterectomy Association - hysterectomy, menopause and hormone replacement therapy (hrt) information and support for women. I had a TAH/BSO in June of 2012 after findings of precancerous cells of the uterus. The surgery went well and minimal pain afterwards. The feeling of my insides “sloshing around” in my abdomen wasn’t something I expected. I had a vertical abdominal incision and since the surgery the abdomen to the right of the incision has been a protrusion, as if my intestines had settled into a ball, in that area. I found out by ...
Source: The Hysterectomy Association - September 11, 2014 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Your Stories bilateral salpingo oophorectomy constipation tah total abdominal hysterectomy Source Type: news

The Opioid Constipation 'Disconnect'The Opioid Constipation 'Disconnect'
Doctors and patients have differing views on the impact of opioid-induced constipation and use of laxatives to relieve this adverse effect. Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - September 10, 2014 Category: Gastroenterology Tags: Neurology & Neurosurgery News Source Type: news

MS and other health conditions
Scottish research has found that people with MS are more likely to have one or more other health conditions (comordities). Most frequent were constipation, visual impairment, pain, migraine, depression, anxiety and epilepsy. People with MS were less likely that the general population to have cardiovascular conditions, kidney disease, coronary heart disease, high blood pressure, dementia or alcohol misuse. MS News Today Latest MS research updates (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - September 7, 2014 Category: Neurology Source Type: news

What Causes Testicular Pain?
Discussion Most inguinal hernias are indirect (i.e. the hernia passes through the internal inguinal ring and down the inguinal canal); only 2% of all hernias in children are direct hernias (i.e. the hernia directly protrudes through the floor of the inguinal canal). Indirect inguinal hernias occur in about 1-5% of infants. They occur on the right side (60%), left side (30%) and bilaterally (10%) and they are more common in premature infants of both sexes. The male : female ratio of inguinal hernias is 4-8 : 1. The chief complaint of testicular or scrotal pain always raises concerns. The acute scrotum generally has pain, ...
Source: PediatricEducation.org - September 1, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Root Down
Beets are an under appreciated superfood. They help with anemia, are high in vitamin C, and are a natural sedative. read more (Source: Psychology Today Food and Diet Center)
Source: Psychology Today Food and Diet Center - August 31, 2014 Category: Nutrition Authors: Heather Lounsbury, L.Ac. Tags: Diet Health anemia anxiety beets Chinese medicine constipation detox emotional emotions energy fix your mood with food heartache Heather Lounsbury immunity laxative Live natural live well liver liver cleanse mental he Source Type: news

Advances in Management of Constipation-predominant IBSAdvances in Management of Constipation-predominant IBS
Is there a treatment that works specifically to improve the complex symptoms associated with constipation-predominent IBS? This new study takes a close look at the safety and efficacy of linaclotide. Therapeutic Advances in Gastroenterology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 28, 2014 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Can auriculotherapy help relieve chronic constipation?
(Mary Ann Liebert, Inc./Genetic Engineering News) Nearly one in six adults worldwide may suffer from chronic constipation and, over time, the disorder can cause serious complications. Auriculotherapy, a form of acupuncture that involves stimulating targeted points on the outer ear, may help in managing constipation. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 25, 2014 Category: Global & Universal Source Type: news

Side Effect Warnings Can Increase Pharmaceutical Sales
I must not be the only person to wonder how pharmaceutical companies succeed with direct to consumer advertisements when, stuck in the middle of all their TV ads, are those long lists of side effects.  You know what I mean.  After watching a smiling and attractive person running through a field after receiving some wonder pill, the narrator tucks his voice down an octave and intones that the medication “could cause rashes, constipation, heartburn, bladder dysfunction and cardiogenic syncope.”  How could anyone listening to this ad want to take this product? (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - August 18, 2014 Category: Pharmaceuticals Authors: Peter Ubel Source Type: news

What Causes Proteinuria?
Discussion Proteinuria occurs relatively often in pediatric practice with 5-15% of school children having transient proteinuria, the most common cause. However, proteinuria can be a sign of kidney disease. Therefore, it is important to evaluate the proteinuria in light of the clinical situation. A good history and physical examination along with a full urinalysis and/or BUN and creatinine, or urine protein/creatinine ratio may be all that is necessary. Another patient with edema, hypertension or hematuria needs a fuller evaluation and treatment. Proteinuria is usually categorized into three groups to assist with evaluation...
Source: PediatricEducation.org - August 18, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

IBS, Chronic Constipation: New Guidelines Issued
(Source: eMedicineHealth.com)
Source: eMedicineHealth.com - August 14, 2014 Category: Journals (General) Source Type: news

Experts Issue Guidelines for Treating Irritable Bowel Syndrome
Certain interventions may ease IBS, while others work against chronic constipation Source: HealthDay Related MedlinePlus Page: Irritable Bowel Syndrome (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - August 8, 2014 Category: Consumer Health News Source Type: news

IBS, Chronic Constipation: New Guidelines Issued
Title: IBS, Chronic Constipation: New Guidelines IssuedCategory: Health NewsCreated: 8/8/2014 11:00:00 AMLast Editorial Review: 8/8/2014 12:00:00 AM (Source: MedicineNet Crohn's Disease General)
Source: MedicineNet Crohn's Disease General - August 8, 2014 Category: Gastroenterology Source Type: news

IBS, Chronic Constipation: New Guidelines Issued
New guidelines offer some new approaches to treating irritable bowel syndrome (IBS) and chronic constipation (CC). (Source: WebMD Health)
Source: WebMD Health - August 7, 2014 Category: Consumer Health News Source Type: news

IBS, Chronic Idiopathic Constipation: New Guidelines IssuedIBS, Chronic Idiopathic Constipation: New Guidelines Issued
New irritable bowel syndrome and constipation treatment guidelines offer up-to-date recommendations on drug therapy and diet. Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - August 6, 2014 Category: Gastroenterology Tags: Gastroenterology News Source Type: news

Vibrating Capsules and Constipation: The Gastro and Endo News Report
(MedPage Today) -- A regular update on what?s new in gastroenterology from our friends at Gastroenterology & Endoscopy News. (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - July 29, 2014 Category: American Health Source Type: news

Elobixibat and Its Role in Chronic Idiopathic ConstipationElobixibat and Its Role in Chronic Idiopathic Constipation
What new drug therapies are available for the treatment of chronic idiopathic constipation? Therapeutic Advances in Gastroenterology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 28, 2014 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Cancer-fighting abilities just one of many aloe vera health benefits
(NaturalNews) Aloe vera, a common household plant, does more than provide a home decor boost. In fact, it does wonders in the ways of healing, helping with everything from halting cancer tumor growth and ending constipation to protecting from oxidative stress and treating candida... (Source: NaturalNews.com)
Source: NaturalNews.com - July 24, 2014 Category: Consumer Health News Source Type: news

NICE recommends Sucampo’s Amitiza for chronic idiopathic constipation treatment
The UK National Institute of Health and Care Excellence (NICE) has recommended Sucampo Pharmaceuticals' Amitiza (lubiprostone) as a treatment option for chronic idiopathic constipation (CIC) and associated symptoms in adults who have failed laxatives… (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - July 23, 2014 Category: Pharmaceuticals Source Type: news

What Causes Abdominal Distention?
Discussion Constipation generally is defined as infrequent or painful defecation. It often is due to passing large hard stool infrequently which causes painful defecation and then withholding behaviors. As stool withholding continues, the rectum dilates and gradually accommodates with the normal defecation urge disappearing. Chronic rectal distension results in both loss of rectal sensitivity, and loss of urge to defecate, which can lead to encopresis. Abdominal distention because of stool retention occurs frequently. Treatment includes colonic evacuation, establishing regular bowel habits, eating a balanced diet with diet...
Source: PediatricEducation.org - July 21, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Three mucilaginous foods that make great natural laxatives
(NaturalNews) Constipation is one of the most common medical conditions affecting Americans today. In fact, the American Society of Colon & Rectal Surgeons claims that approximately 80 percent of people will suffer from infrequent bowel movements at some point in their lives. (1)... (Source: NaturalNews.com)
Source: NaturalNews.com - July 18, 2014 Category: Consumer Health News Source Type: news

Colorectal Cancer Risk in Patients With Chronic ConstipationColorectal Cancer Risk in Patients With Chronic Constipation
Are patients with chronic constipation at an increased risk for colorectal cancer or other forms of colorectal disease? Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 17, 2014 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Promising medication counteracts constipation caused by opioid painkillers
Opioids -- strong morphine-based painkillers -- are widely prescribed to patients experiencing chronic severe pain. While these drugs are very effective for treating and managing pain, they have one particularly bothersome side effect: constipation. A new drug, called naloxegol, could bring relief. In stage 3 trials, international researchers provide new evidence that the drug relieves constipation without dulling opioids' pain-relieving effects. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - July 16, 2014 Category: Science Source Type: news

Promising medication counteracts constipation caused by opioid painkillers
(KU Leuven) Opioids -- strong morphine-based painkillers -- are widely prescribed to patients experiencing chronic severe pain. While these drugs are very effective for treating and managing pain, they have one particularly bothersome side effect: constipation. A new drug, called naloxegol, could bring relief. In stage 3 trials reported in the New England Journal of Medicine, KU Leuven and international researchers provide new evidence that the drug relieves constipation without dulling opioids' pain-relieving effects. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 16, 2014 Category: Cancer & Oncology Source Type: news

Alliance Labs & DocuSol® to be Featured in Upcoming Episode...
DMG Productions explores advancements in constipation relief for children.(PRWeb July 11, 2014)Read the full story at http://www.prweb.com/releases/2014/07/prweb12002506.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - July 11, 2014 Category: Pharmaceuticals Source Type: news

Swissmedic Approves AMITIZA(R) (Lubiprostone) for the Treatment of Opioid-Induced Constipation
(Source: Medical News (via PRIMEZONE))
Source: Medical News (via PRIMEZONE) - July 8, 2014 Category: Pharmaceuticals Source Type: news