[Urinary tract symptoms in Lewy body dementia: About 19 cases].
CONCLUSION: OAB is the most common lower urinary tract symptom in LBD often associated with detrusor overactivity, and less frequently voiding difficulties sometimes associated to prostatism. LEVEL OF EVIDENCE: 3. PMID: 32224094 [PubMed - as supplied by publisher] (Source: Progres en Urologie)
Source: Progres en Urologie - April 2, 2020 Category: Urology & Nephrology Tags: Prog Urol Source Type: research

Management of Chronic Abdominal Distension and Bloating
Abdominal bloating and distension are 2 of the most commonly reported gastrointestinal symptoms. Abdominal bloating is characterized by symptoms of trapped gas, abdominal pressure, and fullness. Abdominal distension is defined as a measurable increase in abdominal girth. These symptoms frequently co-exist, although they can occur separately. Defined by Rome IV criteria, functional abdominal bloating and distension commonly coincide with other functional gastrointestinal disorders, such as functional dyspepsia, irritable bowel syndrome, and functional constipation. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - April 1, 2020 Category: Gastroenterology Authors: Brian E. Lacy, David Cangemi, Maria Vazquez-Roque Source Type: research

Pelvic floor dysfunction symptoms and risk factors at the first year of postpartum women: a cross-sectional study.
CONCLUSION: The most frequent pelvic floor dysfunctions (PFD) after birth were perineal pain, constipation, flatus incontinence, dyspareunia and IU respectively. It was seen that the symptomatic PFD was very common in the postpartum period. The results of the study emphasized the importance of lifestyle changes, avoiding perineal trauma during childbirth, and effective pelvic floor exercises in preventing PFD in pregnancy and postpartum. IMPACT STATEMENT: Nurses should acknowledge the importance of PFD after birth and identify the problems early period. Our study emphasizes size of the problem and improvement for PFD. ...
Source: Contemporary Nurse - March 30, 2020 Category: Nursing Tags: Contemp Nurse Source Type: research

Vitamin A deficiency increases the risk of gastrointestinal comorbidity and exacerbates core symptoms in children with autism spectrum disorder.
CONCLUSIONS: VAD exacerbates core symptoms in children with ASD, and ASD children with GI comorbidities also have more serious core symptoms than ASD children without GI comorbidities. VAD comorbid with GI symptoms aggravates autistic children's core symptoms. IMPACT: VAD exacerbates core symptoms in children with ASD.ASD children with GI comorbidities have more serious core symptoms than ASD children without GI comorbidities.VAD comorbid with GI symptoms aggravates autistic children's core symptoms.We speculate that VAD might be related to a subtype of ASD that involves GI comorbidities.We believe that our findings w...
Source: Pediatric Research - March 30, 2020 Category: Pediatrics Authors: Cheng B, Zhu J, Yang T, Guo M, Lai X, Li Q, Chen J, Li T Tags: Pediatr Res Source Type: research

Top-ten tips for managing nutritional issues and gastrointestinal symptoms in children with neurological impairment
AbstractThe prevalence of children with neurological impairment (NI) presenting feeding difficulties and gastrointestinal symptoms is rising. The most recent guidelines recommend early nutritional assessment and intervention in order to prevent undernutrition and growth failure, along with the proper diagnosis and treatment of some frequent gastrointestinal symptoms, such as gastroesophageal reflux disease (GERD) and constipation, which can further worsen the feeding process and nutritional status. Nonetheless, the nutritional issues and growth deficits of children with NI are often considered to be of low priority or unde...
Source: Italian Journal of Pediatrics - March 27, 2020 Category: Pediatrics Source Type: research

An Unusual Case of Intermittent Cardiac Tamponade
A 64-year-old man presented to his general practitioner complaining of intermittent shortness of breath on exertion, particularly when constipated. His background included a traumatic above the knee amputation and coronary artery bypass surgery 20 years ago using bilateral internal thoracic arteries and the left radial artery; this was complicated by a deep sternal wound infection that required sternal debridement and bilateral pectoral flaps advancement. A recurrent infection 3 months later was treated with a second debridement and partial sternectomy followed by pedicled omental flap reconstruction. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - March 26, 2020 Category: Cardiology Authors: F. Ramponi, M.G. Carelli, N. Ang, K.T.H. Win, P. Shah, P. Palamuthusingam, S. Yadav Tags: Image Source Type: research

Development of a Patient-Centered Pelvic Floor Complication Scale
Objective The aim of the study was to evaluate patient responses on a survey of knowledge, perceptions, concerns, and fears about complications related to pelvic reconstructive surgery (PRS). This is the first step to create a simplified, patient-centered Pelvic Floor Complication Scale that evaluates complications from both the patient and surgeon perspective. Methods Subjects for this prospective study included women older than 18 years planning surgery within 12 weeks or who had undergone PRS more than 6 months ago. Patients were asked open-ended questions about postoperative complications as well as to rank the se...
Source: Female Pelvic Medicine and Reconstructive Surgery - March 25, 2020 Category: OBGYN Tags: Original Articles Source Type: research

Epidemiology of Functional Abdominal Pain Disorders and Functional Defecation Disorders in Adolescents in Curacao
Conclusions: FAPDs and FDDs are common in adolescents in Curacao. Dizziness is associated with the presence of a FAPD or FDD. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - March 24, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Correlations among pain, depressive symptoms, constipation, and serotonin levels in smokers and non smokers
This study was a secondary analysis of a randomized clinical trial.FindingsSmokers had more pain, depressive symptoms, and constipation than non smokers. Smokers had similar serotonin levels compared with non smokers. Positive correlations were observed between constipation and serum serotonin levels (r = .19,P = .039, n = 116), between constipation and depressive symptoms (r  =  .18,P = .023, n = 164), and between constipation and pain (r = .23,P = .004, n = 164) in smokers.Practical ImplicationsHe...
Source: Perspectives in Psychiatric Care - March 24, 2020 Category: Psychiatry Authors: Eun Jin Lee Tags: ORIGINAL ARTICLE Source Type: research

A Renal Impairment Subgroup Analysis of the Safety and Efficacy of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with Chronic Non-Cancer Pain Receiving Opioid Therapy
(Source: Journal of Pain Research)
Source: Journal of Pain Research - March 24, 2020 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research

The Effects of the Rome IV Criteria on Pediatric Gastrointestinal Practice
AbstractPurpose of ReviewTo evaluate the impact of the implementation of the Rome IV criteria on pediatric gastrointestinal practice.Recent FindingsIn 2016, the Rome IV criteria were published, providing an update of symptom-based criteria to diagnose children with functional gastrointestinal disorders (FGIDs).SummaryFor neonates and toddlers, Wessel ’s criteria for diagnosing infant colic were abandoned, and a differentiation was made between toilet-trained and non-toilet-trained children in the diagnosis of functional constipation. For children and adolescents, two new disorders (functional nausea and functional vo...
Source: Current Gastroenterology Reports - March 19, 2020 Category: Gastroenterology Source Type: research

Analyzing the Role of Anal Sphincter Pressure in Rectocele Formation.
Conclusion: We have proved the hypothesis arguing that increased sphincter pressures do not play a role in the formation of rectocele by inducing an obstruction and the formation of dilation in proximal bowel, and demonstrated that the presence of rectocele is not dependent on an increase in sphincter pressures. PMID: 32178503 [PubMed - as supplied by publisher] (Source: Annals of Coloproctology)
Source: Annals of Coloproctology - March 18, 2020 Category: Gastroenterology Tags: Ann Coloproctol Source Type: research

Molecules, Vol. 25, Pages 1370: Comparisons of In Vivo and In Vitro Opioid Effects of Newly Synthesized 14-Methoxycodeine-6-O-sulfate and Codeine-6-O-sulfate
This study provides first evidence that 14-OMeC6SU is more effective than codeine or C6SU in vitro and in vivo. Furthermore, despite C6SU peripheral antihyperalgesic effects with less gastrointestinal side effects the superiority of 14-OMeC6SU was obvious throughout the present study. (Source: Molecules)
Source: Molecules - March 17, 2020 Category: Chemistry Authors: Z ádor Mohammadzadeh Balogh Z ádori Kir ály Barsi Galambos L ászló Hutka V áradi Hosztafi Riba Benyhe F ürst Al-Khrasani Tags: Article Source Type: research

Prevention and management of complications in various antegrade enema procedures in children: a review of the literature
AbstractThe antegrade continence enema (ACE) procedures are successful surgical options to achieve bowel cleaning in children with faecal incontinence due to a neuropathy or an anorectal malformation and an intractable constipation. The reversed and orthotopic appendicocecostomy, tubularized ileal conduit and the tubularized cecal flap are frequently applied procedures in the treatment of faecal incontinence (FI). The most common complications are the stoma stenosis, leakage, prolapse, adhesive obstruction and the difficulty in catheterization. Each procedure has its own advantages and disadvantages with different complica...
Source: Pediatric Surgery International - March 17, 2020 Category: Surgery Source Type: research

Mirogabalin besylate in the treatment of neuropathic pain.
Authors: Burgess J, Javed S, Frank B, Malik RA, Alam U Abstract Neuropathic pain (NeP) is a global cause of suffering and debilitation leading to significant morbidity and reduced quality of life. New treatments are needed to address the growing prevalence of NeP and its impact on sleep, mood and functionality. Mirogabalin besylate (mirogabalin, Tarlige) is a gabapentinoid therapy developed by Daiichi Sankyo which is approved in Japan for the treatment of postherpetic neuralgia and painful diabetic peripheral neuropathy. Mirogabalin has a potent pain-modulating effect with a unique high affinity and prolonged disso...
Source: Drugs of Today - March 14, 2020 Category: Drugs & Pharmacology Tags: Drugs Today (Barc) Source Type: research

Long-term outcomes of single-incision laparoscopic technique in Soave procedure compared with heart-shaped anastomosis for Hirschsprung disease
ConclusionSILHSA is a feasible and reliable minimally invasive surgical procedure for patients with HSCR. Patients who underwent SILHSA had lower incidence rates of constipation and soiling than patients who underwent SILSP, suggesting that SILHSA could be a better choice for patients with HSCR. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - March 14, 2020 Category: Gastroenterology Source Type: research

Efficacy and Safety of 5-HT4 Receptor Agonist Minesapride for Irritable Bowel Syndrome with Constipation in a Randomized Controlled Trial
Treatment options for irritable bowel syndrome with constipation (IBS-C) are limited —new prokinetic drugs are needed. We evaluated the efficacy and safety of minesapride (DSP-6952), a partial agonist with high affinity for 5-HT4 receptors, in patients with IBS-C in Japan. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 14, 2020 Category: Gastroenterology Authors: Shin Fukudo, Masatoshi Nakamura, Tatsuto Hamatani, Kiyoyasu Kazumori, Hiroto Miwa Source Type: research

Anterior Sacral Meningocele: A New Classification and Treatment Using the Dorsal Transsacral Approach
Conclusion. Aim of surgical treatment is to obliterate the communication between the subarachnoid space and herniated sac, detether the spinal cord, and resect the congenital tumor. The new classification helps to recognize the relationship between the meningocele and sacral nerve roots, and subsequently adopt different surgical strategies. We consider the dorsal transsacral approach relatively feasible, safe, and with lower complication. Level of Evidence: 4 (Source: Spine)
Source: Spine - March 13, 2020 Category: Orthopaedics Tags: CLINICAL CASE SERIES Source Type: research

Obstipation and diarrhoea in palliative care —a pharmacist’s view
This article is a brief overview of drugs, which are of use in the treatment of constipation and diarrhoea in palliative care. Whereas most of the drugs mentioned are widely used and known, the aspect of gastrointestinal symptoms as side effect of pharmacological treatments is often underestimated. Therefore, the article highlights the approach of deprescribing, as a tool to reduce both, pill burden and symptoms. (Source: Memo - Magazine of European Medical Oncology)
Source: Memo - Magazine of European Medical Oncology - March 13, 2020 Category: Cancer & Oncology Source Type: research

College Women ’s Experiences With Urinary Storage Symptoms
Lower urinary tract storage symptoms are common women ’s health conditions that increase with advancing age. However, symptoms are also common among young women. Understanding the experience of symptoms in young women may help to decrease symptom progression across the life span. The current study was a quantitative Web-based study of female undergra duates. The most commonly reported symptoms were urinary frequency, urgency, and urinary incontinence. Factors that were significantly associated with lower urinary tract storage symptoms included constipation/irritable bowel syndrome, sexual activity, and delayed and/or...
Source: The Journal for Nurse Practitioners - March 13, 2020 Category: Nursing Authors: Kimberly J. Angelini, M. Katherine Hutchinson, Melissa A. Sutherland, Mary H. Palmer, Diane K. Newman Tags: Original Research Source Type: research

C13Efficacy in Cancer Versus Non-cancer Patients Treated with Methylnaltrexone: An Analysis of Two Placebo-controlled Studies
Methylnaltrexone (MNTX, Relistor ®) inhibits opioid peripheral adverse effects. This post hoc analysis evaluated pooled data from 2 randomized, double-blind studies and open-label extensions of adults with advanced illness and opioid-induced constipation. (Source: Pain Management Nursing)
Source: Pain Management Nursing - March 12, 2020 Category: Nursing Authors: Michelle Rhiner Source Type: research

C12Treatment with Methylnaltrexone in Patients with Opioid-Induced Constipation with or without Active Cancer
Subcutaneous (SC) methylnaltrexone (MNTX, Relistor ®) is approved for opioid-induced constipation (OIC) in adults with chronic noncancer pain and OIC in adults with advanced illness or with active cancer who require opioid dosage escalation for palliative care. This post hoc analysis evaluated data pooled from 3 randomized studies of patients with advanced illness and OIC. (Source: Pain Management Nursing)
Source: Pain Management Nursing - March 12, 2020 Category: Nursing Authors: Michelle Rhiner Source Type: research

Laxative Effects of Yangyin Tongmi Capsule on a Model of Diphenoxylate-Induced Constipation in Mice.
Authors: Liu S, Sui D, Fu W, Yu X, Li Y, Wu X, Hou Y, Guo M, Xu H Abstract Constipation is characterized by reduced number of bowel movements, dry stools, and difficult defecation. Yangyin Tongmi capsule (YTC), a traditional Chinese formula, is used in the treatment of constipation, while the underlying mechanisms remain unknown. Herein, this work attempted to prove the effects of YTC on constipation treatment and its possible mechanisms. KM mice were randomly divided into four groups (n = 10/group) and treated with double distilled water (Control), diphenoxylate (Model: 10 mg/kg), or diphenoxy...
Source: Evidence-based Complementary and Alternative Medicine - March 11, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Probiotic Lactobacillus plantarum IS 10506 supplementation increase SCFA of women with functional constipation.
Conclusion: Probiotic Lactobacillus plantarum IS 10506 supplementation influenced all the SCFA parameter (acetate, propionate and butyrate). PMID: 32148669 [PubMed] (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - March 11, 2020 Category: Microbiology Tags: Iran J Microbiol Source Type: research

Breath Methane Does Not Correlate With Constipation Severity or Bloating in Patients With Constipation
Goals: We aimed to study (1) if the breath methane level on glucose breath testing (GBT) was associated with constipation severity and (2) compare methane levels between patients with constipation and diarrhea. Background: The breath methane level has been associated with constipation and its severity. However, a few recent studies have questioned these associations. Study: Patients presenting consecutively to a tertiary care gastroenterology motility laboratory for GBT were included. GBT was performed using 75-g glucose load following a standard, institutional protocol. Constipation and irritable bowel syndrome (I...
Source: Journal of Clinical Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Stapled Surgery for Hemorrhoidal Prolapse: From the Beginning to the Modern Times.
CONCLUSIONS: Stapled procedure for the treatment of symptomatic hemorrhoidal prolapse represents one of the most important innovations in proctology of the last century bringing with it the new revolutionary concept of the rectal intussusception as a determining factor involved in the natural history of the disease. Stapled hemorrhoidopexy marked an era in which the surgeon may to offer to the patients a safe, effective treatment with less pain and fast recovery. PMID: 32156241 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - March 10, 2020 Category: Cancer & Oncology Authors: Sturiale A, Fabiani B, Menconi C, Cafaro D, Porzio FC, Naldini G Tags: Rev Recent Clin Trials Source Type: research

The European Medicines Agency Review of Gilteritinib (Xospata) for the Treatment of Adult Patients with Relapsed or Refractory Acute Myeloid Leukemia with an FLT3 Mutation.
The objective of this article is to summarize the scientific review of the application leading to regulatory approval in the EU. IMPLICATIONS FOR PRACTICE: Xospata was approved in the European Union as monotherapy for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with an Fms-like tyrosine kinase 3 (FLT3) mutation. Gilteritinib resulted in a clinically meaningful and statistically significant improvement of overall survival compared with salvage chemotherapy. At the time of the marketing authorization of gilteritinib, there were no approved standard therapies specifically for adult...
Source: The Oncologist - March 10, 2020 Category: Cancer & Oncology Authors: Tzogani K, Røshol H, Olsen HH, Aas IB, Dalhus ML, Håkonsen GD, Nilssen LS, Lindberg V, Økvist M, Bolstad B, Rogovska I, Karpova N, Enzmann H, Gisselbrecht C, Pignatti F Tags: Oncologist Source Type: research

Comparison of Clinical Symptoms of Assumed vs. Actual Uterine Fibroids - Symptoms Described by Patients and Ultrasound Findings.
Conclusions The presence of manifest symptoms (dysmenorrhea, dyspareunia, premenstrual pain, bleeding disorders) does not allow conclusions to be made about the number or size of fibroids or about which therapy is indicated. Even an erroneous assumption about the presence of fibroids may result in patients experiencing symptoms. PMID: 32139921 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - March 8, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Does concurrent posterior repair for an asymptomatic rectocele reduce the risk of surgical failure in patients undergoing sacrocolpopexy?
ConclusionsFor patients with asymptomatic rectoceles, a concurrent posterior repair at the time of sacrocolpopexy reduces the odds of composite patient-centered failure without an increased rate of dyspareunia or de novo defecatory dysfunction. (Source: International Urogynecology Journal)
Source: International Urogynecology Journal - March 7, 2020 Category: OBGYN Source Type: research

Irritable bowel syndrome in Indonesian adolescents.
CONCLUSIONS: The prevalence of irritable bowel syndrome in adolescents was high, with bullying, female gender, age 14-16 years, constipation and diarrhea, and dietary consumption of soft drinks, coffee, and tea as risk factors. A significant association with intestinal inflammation was found. PMID: 32156535 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - March 7, 2020 Category: Pediatrics Authors: Kesuma Y, Sekartini R, Timan IS, Kurniawan A, Bardosono S, Firmansyah A, Vandenplas Y Tags: J Pediatr (Rio J) Source Type: research

Evaluating naloxegol for the treatment of opioid-induced constipation.
Authors: Daniali M, Nikfar S, Abdollahi M Abstract Introduction: Due to the increased use of opioids for pain and their abuse globally, the rate of restrictive side effects is elevating. Opioid-induced constipation (OIC) is probably the most widespread, underdiagnosed, and yet common adverse effect. Naloxegol, as an opioid antagonist, is associated with beneficial impacts in OIC. Indeed, blocking mu (μ)-opioid receptors in the gastrointestinal tract (GI) may lead to neutralization of the GI adverse events of opioids.Areas covered: This review is based on a PubMed and Clinicaltrials.gov search for studies underta...
Source: Expert Opinion on Pharmacotherapy - March 6, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

Functional Outcome and Sexual-Related Quality of Life After Transperineal Versus Transvaginal Repair of Anterior Rectocele: A Randomized Clinical Trial
CONCLUSION: Transvaginal repair of rectocele achieved better improvement in constipation and sexual-related quality of life than transperineal repair. Changes in dyspareunia after both techniques were not significant. See Video Abstract at http://links.lww.com/DCR/B148. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03801291. RESULTADO FUNCIONAL Y CALIDAD DE VIDA RELACIONADA CON EL SEXO DESPUÉs DE LA REPARACIÓN TRANSPERINEAL VERSUS TRANSVAGINAL DEL RECTOCELE ANTERIOR: UN ENSAYO CLÍNICO ALEATORIZADO ANTECEDENTES: Los métodos de tratamiento del rectocele incluyen los abord...
Source: Diseases of the Colon and Rectum - March 6, 2020 Category: Gastroenterology Tags: Original Contributions: Pelvic Floor Source Type: research

Evaluation and Management of Hemorrhoids
Case Summary: A 46-year-old otherwise healthy female patient presents with bright red blood during defecation and a lump protruding on defecation that requires manual reduction. She is the mother of 2 children and has a long history of constipation. (Source: Diseases of the Colon and Rectum)
Source: Diseases of the Colon and Rectum - March 6, 2020 Category: Gastroenterology Tags: Resident’s Corner Source Type: research

Thorough QT/QTc Study Shows That a Novel 5 ‐HT4 Receptor Partial Agonist Minesapride Has No Effect on QT Prolongation
AbstractMinesapride (drug code: DSP ‐6952) is a potential gastrointestinal prokinetic agent with high selectivity for 5‐hydroxytryptamine 4 (5‐HT4) receptor that acts as a partial agonist. Although 5 ‐HT4 receptor agonists are expected to show efficacy in patients with irritable bowel syndrome with constipation, only tegaserod is available for female patients, with limitations, in the United States. Previously, another 5 ‐HT4 receptor agonist, cisapride, was widely used for the treatment of upper gastrointestinal diseases, but was withdrawn from the market because of arrhythmia with QT prolongation. Chemically, b...
Source: Clinical Pharmacology in Drug Development - March 5, 2020 Category: Drugs & Pharmacology Authors: Tatsuto Hamatani, Naoto Noda, Takeshi Takagaki, Yasuhide Yodo, Hirotaka Kawai, Hiroyoshi Kakuyama, Yoshikazu Kaji, Yasushi Fujio Tags: Original Manuscript Source Type: research

Soluble Dietary Fiber Reduces Feeding Intolerance in Severe Acute Pancreatitis: A Randomized Study.
This study was a single-blind, randomized, controlled, single-center trial. Forty-nine patients with SAP were included. The control and SDF groups received the same EN solution via a nasojejunal tube. The SDF group additionally received 20-g/d polydextrose. The primary outcome was the time to reach the energy goal. Follow-up was continued for 28 days after admission or until discharge from the hospital. RESULTS: Among 49 randomized patients, 46 patients (n = 22, control group; n = 24, SDF group) were included in the intent-to-treat analysis. The time to reach the energy goal was 7.00 (6.00, 8.25) d...
Source: JPEN Journal Of Parenteral And Enteral Nutrition - March 5, 2020 Category: Nutrition Authors: Chen T, Ma Y, Xu L, Sun C, Xu H, Zhu J Tags: JPEN J Parenter Enteral Nutr Source Type: research

Laparoscopic Soave procedure for long-segment Hirschsprung's disease - single-center experience.
Conclusions: A small volume centre may achieve satisfactory results for long-segment HD. The laparoscopic Soave procedure is a minimally invasive, safe and effective treatment. PMID: 32117510 [PubMed] (Source: Videosurgery and Other Miniinvasive Techniques)
Source: Videosurgery and Other Miniinvasive Techniques - March 3, 2020 Category: Surgery Tags: Wideochir Inne Tech Maloinwazyjne Source Type: research

Sodium phosphate is superior to polyethylene glycol in constipated patients undergoing colonoscopy: a systematic review and meta-analysis
ConclusionsIn chronically constipated patients undergoing colonoscopy, the use of NaP may result in superior colonic cleanliness when compared to PEG, however, quality of evidence was low. Further high-quality studies are required to delineate the optimal bowel preparation in patients with constipation. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - March 2, 2020 Category: Surgery Source Type: research

A LYSA Phase Ib Study of tazemetostat (EPZ-6438) plus R-CHOP in newly diagnosed Diffuse Large B Cell Lymphoma (DLBCL) patients with poor prognosis features.
CONCLUSIONS: The RP2D of tazemetostat combined with R-CHOP is 800 mg BID. The association presents safety and PK comparable to R-CHOP alone. Preliminary efficacy data are encouraging and further investigations in phase 2 trial are warranted. PMID: 32122924 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - March 2, 2020 Category: Cancer & Oncology Authors: Sarkozy C, Morschhauser F, Dubois S, Molina T, Michot JM, Cuillière-Dartigues P, Suttle B, Karlin L, Le Gouill S, Picquenot JM, Dubois R, Tilly H, Herbaux C, Jardin F, Salles G, Ribrag V Tags: Clin Cancer Res Source Type: research

A Rare Case of Cecal Bascule in a Child With Normal Neurodevelopment
We present the case of a 10-year-old boy who presented with an acute history of left lower quadrant abdominal pain, who upon investigation was found to have a cecal bascule. (Source: Pediatric Emergency Care)
Source: Pediatric Emergency Care - March 1, 2020 Category: Emergency Medicine Tags: Illustrative Cases Source Type: research

Lower urinary tract symptoms and related factors in female university students
ConclusionsLower urinary tract complaints are a common problem. We believe that routine medical screening should be performed for female university students whose living conditions change when they start university; besides, we suggest that well ‐attended and repeatable training programs for healthy living behaviors, urinary habits, and hygiene should be organized for university students. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - February 28, 2020 Category: Urology & Nephrology Authors: Sebahat G ücük, Ülkü M. Ural, Mehmet Kayhan, Adnan Gücük Tags: ORIGINAL ARTICLE Source Type: research

Ultrasonic Chinese herbal medication penetration therapy at Tiānshū (天枢 ST25) for opioid-induced constipation with liver stagnation and spleen deficiency
Publication date: Available online 1 February 2020Source: World Journal of Acupuncture - MoxibustionAuthor(s): Na SONG, Ling-zhan MENG, Jun CHENG, Ying LI, Xin ZHOU, Jing WANG, Hong-jian XU, Xuan GAO, Zong-lang LAI (Source: World Journal of Acupuncture Moxibustion)
Source: World Journal of Acupuncture Moxibustion - February 28, 2020 Category: Complementary Medicine Source Type: research

Sicca Symptoms in Parkinson's Disease: Association with Other Nonmotor Symptoms and Health-Related Quality of Life.
Conclusion: Sicca symptoms are common in PD and negatively influence QoL. The observed association between sicca symptoms and other nonmotor symptoms provides further preliminary evidence for the growing recognition of different nonmotor clusters in PD. PMID: 32104559 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - February 28, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

75: Surgical correction of obstructed defecation syndrome
We present a video description of anterior rectopexy at the time of sacrocolpopexy with obliteration of the rectovaginal space to address posterior compartment prolapse as a cause of outlet constipation. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - February 28, 2020 Category: OBGYN Authors: T. Cui, C.A. Matthews Tags: Video Cafe Source Type: research

Treatment of Childhood Constipation: a synthesis of systematic reviews and meta-analyses.
Authors: Southwell BR Abstract Introduction: Constipation occurs in many children and can become chronic. Many grow out of it but for one third, it continues into adulthood. For most patients there is no identifiable organic disorder and it is classified as functional constipation.Areas covered: In 2016, the field was extensively reviewed by Rome IV. This review covers meta-analyses and evidence for treatment of paediatric constipation since 2016 and new emerging treatments.Expert opinion: Since 2016, meta-analyses conclude 1) fibre should be included in a normal diet, but further supplementation does not improve c...
Source: Expert Review of Gastroenterology and Hepatology - February 28, 2020 Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research

Thorough QT/QTc Study Shows That a Novel 5 ‐HT4 Receptor Partial Agonist Minesapride Has No Effect on QT Prolongation
AbstractMinesapride (drug code: DSP ‐6952) is a potential gastrointestinal prokinetic agent with high selectivity for 5‐hydroxytryptamine 4 (5‐HT4) receptor that acts as a partial agonist. Although 5 ‐HT4 receptor agonists are expected to show efficacy in patients with irritable bowel syndrome with constipation, only tegaserod is available for female patients, with limitations, in the United States. Previously, another 5 ‐HT4 receptor agonist, cisapride, was widely used for the treatment of upper gastrointestinal diseases, but was withdrawn from the market because of arrhythmia with QT prolongation. Chemically, b...
Source: Clinical Pharmacology in Drug Development - February 28, 2020 Category: Drugs & Pharmacology Authors: Tatsuto Hamatani, Naoto Noda, Takeshi Takagaki, Yasuhide Yodo, Hirotaka Kawai, Hiroyoshi Kakuyama, Yoshikazu Kaji, Yasushi Fujio Tags: Original Manuscript Source Type: research

Gut microbiota and stroke
Benjamin Y. Q. Tan, Prakash R Paliwal, Vijay K SharmaAnnals of Indian Academy of Neurology 2020 23(2):155-158 Ischemic stroke remains a significant health problem, which is expected to increase owing to an aging population. A considerable proportion of stroke patients suffer from gastrointestinal complications, including dysphagia, gastrointestinal hemorrhage, and constipation. Often, these complications adversely affect stroke outcomes. Recent research postulates the role of “brain-gut axis” in causing gut microbiota dysbiosis and various complications and outcomes. In this review, we present our current unde...
Source: Annals of Indian Academy of Neurology - February 26, 2020 Category: Neurology Authors: Benjamin Y. Q. Tan Prakash R Paliwal Vijay K Sharma Source Type: research

Overview on the management of adult urinary incontinence
Urinary incontinence is a common presentation and can manifest either as stress, urge or mixed incontinence. Though primarily a condition affecting women, the increasing uptake of prostate surgery for benign disease and cancer, whereupon up to one in five patients end up experiencing stress incontinence, means the prevalence of incontinence in men is increasing. A thorough assessment is necessary to identify the underlying urological abnormality and to guide appropriate management. Conservative approaches consist of treating constipation, the use of containment devices, weight loss, bladder training and pelvic floor muscle...
Source: Surgery (Medicine Publishing) - February 26, 2020 Category: Surgery Authors: Bob Yang, Steve Foley Tags: Renal and urological surgery - III Source Type: research

Abnormal Intestinal Microbiome in Medical Disorders and Potential Reversibility by Fecal Microbiota Transplantation
AbstractReduction in diversity of the intestinal microbiome (dysbiosis) is being identified in many disease states, and studies are showing important biologic contributions of microbiome to health and disease. Fecal microbiota transplantation (FMT) is being evaluated as a way to reverse dysbiosis in diseases and disorders in an attempt to improve health. The published literature was reviewed to determine the value of FMT in the treatment of medical disorders for which clinical trials have recently been conducted. FMT is effective in treating recurrentC. difficile infection in one or two doses, with many healthy donors prov...
Source: Digestive Diseases and Sciences - February 25, 2020 Category: Gastroenterology Source Type: research

Gut Microbiota Altered in Mild Cognitive Impairment Compared With Normal Cognition in Sporadic Parkinson's Disease
Conclusion: Compared with HC and patients with PD-NC, the gut microbiota of patients with PD-MCI was significantly altered, particularly manifesting in enriched genera from Porphyromonadaceae family and decreased the abundance of genera Blautia and Ruminococcus. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 25, 2020 Category: Neurology Source Type: research

Peripheral Opioid Receptor Antagonists for Opioid-Induced Constipation: A Primer on Pharmacokinetic Variabilities with a Focus on Drug Interactions
(Source: Journal of Pain Research)
Source: Journal of Pain Research - February 24, 2020 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research