The effect of gum consumption on blood pressure as a risk factor for coronary heart disease: A meta-analysis of controlled trials.
Authors: Shao B, Li H, Zhang P, Teng X, Wang H, Verdi T, Bhat LT, Zhang F Abstract Guar gum has been used in the management of hypercholesterolemia, constipation, weight loss, type 2 diabetes mellitus and hypertension. Our aim was to verify the hypothesis that Guar gum can be used as an alternative to pharmacological agents in the treatment of mild hypertension. Thus, we conducted a systematic review and meta-analysis to evaluate the effectiveness of Guar gum in reducing blood pressure. We searched the Cochrane Library, PubMed/Medline, Scopus and Google Scholar databases for studies published in the English langua...
Source: International Journal for Vitamin and Nutrition Research - January 22, 2021 Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research

Would Some Herbal Teas Play a Medicating Role for Certain Diseases?
Herbal Teas prepared from leaves, roots, fruits, and flowers of different herbs contain many useful nutrients that may be a good replacement for medicating certain diseases. These herbal teas are very rich in poly-phenols, therefore are significant for their antioxidant, anti-inflammation, anticancer, anticardiovascular, antimicrobial, antihyperglycemic, and antiobesity properties. Medical chronic conditions, such as cardiovascular diseases, cancer, Alzheimer’s disease, Parkinson’s disease, constipation, diabetes, and bed wetting in children can be easily cured by the use of these herbal teas in regular and mod...
Source: Current Nutrition and Food Science - January 22, 2021 Category: Nutrition Source Type: research

Tapentadol vs oxycodone for postoperative pain treatment the first 7 days after total knee arthroplasty: a randomized clinical trial
This study compared the effectiveness of tapentadol extended-release (ER) 50 mg × 2, oxycodone controlled-release (CR) 10 mg × 2, and placebo, as added to a multimodal analgesic regime both in-hospital and at home the first week after total knee arthroplasty. The study was randomized and blinded for investigators, staff, outcome assessors, and patients. Follow-up included pain intensity on mobilization, pain at rest, worst pain in the previous 24 hours, and adverse effects measured on 0 to 10 numerical rating scales. A total of 134 patients in 3 study groups received their allocated intervention and were includ...
Source: Pain - January 22, 2021 Category: Anesthesiology Tags: Research Paper Source Type: research

Aurora kinase A inhibitor, LY3295668 erbumine: a phase 1 monotherapy safety study in patients with locally advanced or metastatic solid tumors
Conclusions MTD of LY3295668 was 25 mg BID. LY3295668 had a manageable toxicity profile and demonstrated activity in some patients with locally advanced or metastatic solid tumors.Trial registration, NCT03092934. Registered March 22, 2017. (Source: Investigational New Drugs)
Source: Investigational New Drugs - January 22, 2021 Category: Drugs & Pharmacology Source Type: research

Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
Abstract BACKGROUND: Constipation is a common problem in children with spastic cerebral palsy (sCP) with a prevalence that reaches 75%. We hypothesized that treating constipation in those children will improve their health and shorten time spent in daily care. Our aim was to evaluate the efficacy and safety of oral magnesium sulfate for treating chronic constipation in children with sCP. METHODS: A prospective, double-blinded randomized control trial was carried out involving 100 children aged 2-12 years with sCP (level III-V of the Gross Motor Functional Classification system) and chronic constipation. ...
Source: World Journal of Pediatrics : WJP - January 22, 2021 Category: Pediatrics Authors: Hassanein SMA, Deifallah SM, Bastawy HA Tags: World J Pediatr Source Type: research

Gut Microbiota Composition Changes in Constipated Women of Reproductive Age
BackgroundChronic constipation is one of the most prevalent functional gastrointestinal disorders, yet its etiology is multifactorial, and the pathophysiological mechanism is still unclear. Previous studies have shown that the gut microbiota of constipated patients differs from healthy controls; however, many discrepancies exist in the findings, and no clear link has been confirmed between chronic constipation and changes in the gut microbiota. Growing evidence indicates that age, gender, and hormone levels can affect the composition of gut microbiota. The aim of this study is to examine the overall changes in gut microbio...
Source: Frontiers in cellular and infection microbiology - January 21, 2021 Category: Microbiology Source Type: research

Managing functional constipation: the course doesn ’t always run smooth
AbstractChronic functional constipation is symptomatically defined and includes dyssynergic defaecation and normal and slow transit constipation, not secondary to drugs or other conditions. Dietary soluble fibre and laxatives are key treatments, with biofeedback helpful especially in dyssynergic defaecation. Newer pro-secretory and motility-stimulating agents may help those non-responsive to over-the-counter treatments. Although head-to-head and combination therapy trials are lacking, combination therapy in people not responsive to monotherapy is a reasonable approach. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - January 21, 2021 Category: Drugs & Pharmacology Source Type: research

Timely diagnosis of multiple endocrine neoplasia 2B by identification of intestinal ganglioneuromatosis: a case series
ConclusionsNeonatal GI manifestations offer the most important window of opportunity for early detection of MEN2B. By accurate evaluation of rectal biopsies in patients with early onset severe constipation, IGN can be timely detected, while ruling out Hirschsprung ’s disease. MEN2B gene analysis should follow detection of IGN and—when confirmed—should prompt possibly still curative thyroid surgery. (Source: Endocrine)
Source: Endocrine - January 21, 2021 Category: Endocrinology Source Type: research

First-line atezolizumab monotherapy in patients with advanced BRAFV600 wild-type melanoma.
Abstract Anti-programmed death 1 agents are an established option for advanced melanoma, but the anti-programmed death ligand 1 (anti-PD-L1) antibody atezolizumab, an agent approved for the treatment of multiple solid tumors, was not previously evaluated. This phase 1b study cohort (NCT03178851; cohort C) evaluated first-line atezolizumab 1200 mg every 3 weeks in adults with BRAFV600 wild-type, histologically confirmed, advanced or metastatic melanoma. The co-primary end points were confirmed objective response rate (ORR) per Response Evaluation Criteria in Solid Tumors v1.1 and disease control rate (DCR = complet...
Source: Pigment Cell and Melanoma Research - January 21, 2021 Category: Cytology Authors: de Azevedo SJ, de Melo AC, Roberts L, Caro I, Xue C, Wainstein A Tags: Pigment Cell Melanoma Res Source Type: research

The Sphincter of O ’Beirne – Part 1: Study of 18 Normal Subjects
ConclusionsThe rectosigmoid junction is a functional sphincter that should be referred to as the sphincter of O ’Beirne; it is part of the “braking mechanism,” contributing to continence by keeping content away from the rectum. In an accompanying case report, we show that its excessive presence in a patient with severe constipation can be a primary pathophysiology. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 19, 2021 Category: Gastroenterology Source Type: research

The Sphincter of O ’Beirne—Part 2: Report of a Case of Chronic Constipation with Autonomous Dyssynergia
ConclusionsChronic constipation without the presence of spontaneous bowel movements can be associated with normal colonic motor patterns but a highly exaggerated pressure at the rectosigmoid junction: the sphincter of O ’Beirne, and failure of this sphincter and the anal sphincters to relax associated with propulsive motor patterns. The sphincter of O’Beirne can be an important part of the pathophysiology of chronic constipation. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 19, 2021 Category: Gastroenterology Source Type: research

Case Report: 7-Year-Old Boy with Incarcerated Internal Hernia Leading to Extensive Intestinal Necrosis Due to a Large Congenital Mesenteric Defect
We present a case of a 7-year-old boy with acute abdominal symptoms initially misdiagnosed as constipation. Delayed imaging diagnostics revealed an ileus with contorted small intestine, so laparotomy was indicated. An acute bowel obstruction was found based on an incarcerated internal hernia. Small and large bowel segments were incarcerated into a large mesenteric defect leading to extended intestinal necrosis. About 30 cm of necrotic small bowel and 15 cm of large intestine were resected, two primary anastomoses were performed. The mesenteric defect was closed with two running sutures. The boy’s clinical outcome was...
Source: Klinische Padiatrie - January 19, 2021 Category: Pediatrics Authors: Deeg, Susanne Krickeberg, Sophie Nisar, Tauseef Schwarz-Bundy, Bogata Dora Wessel, Lucas Tags: Original Article Source Type: research

Constipation due to a stroke complicated with pseudo-obstruction (Ogilvie's Syndrome).
PMID: 33459344 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - January 18, 2021 Category: Neurology Authors: Madalinski M Tags: Neurol Neurochir Pol Source Type: research

Wheat flour fortification with iron and other micronutrients for reducing anaemia and improving iron status in populations.
CONCLUSIONS: Fortification of wheat flour with iron (in comparison to unfortified flour, or where both groups received the same other micronutrients) may reduce anaemia in the general population above two years of age, but its effects on other outcomes are uncertain. Iron-fortified wheat flour in combination with other micronutrients, in comparison with unfortified flour, probably reduces iron deficiency, but its effects on other outcomes are uncertain. None of the included trials reported data on adverse side effects except for risk of infection or inflammation at the individual level. The effects of this interventio...
Source: Cochrane Database of Systematic Reviews - January 18, 2021 Category: General Medicine Authors: Field MS, Mithra P, Peña-Rosas JP Tags: Cochrane Database Syst Rev Source Type: research

Prospect of microbial food borne diseases in Pakistan: a review.
Abstract Nowadays food borne illness is most common in people due to their epidemic nature. These diseases affect the human digestive system through bacteria, viruses and parasites. The agents of illness are transmitted in our body through various types of food items, water and uncooked. Pathogens show drastic changes in immunosuppressant people. This review gives general insights to harmful microbial life. Pakistan is a developed country and because of its improper food management, a lot of gastrointestinal problems are noted in many patients. Bacteria are most common agents to spread diarrhoea, villi infection, ...
Source: Braz J Biol - January 18, 2021 Category: Biology Authors: Ishaq AR, Manzoor M, Hussain A, Altaf J, Rehman SU, Javed Z, Afzal I, Noor A, Noor F Tags: Braz J Biol Source Type: research

Pharmacist ’s knowledge regarding the management of overactive bladder in elderly women
Anticholinergic drugs used to treat overactive bladder (OAB), have common side effects, including constipation, dry eyes and dry mouth. They can also cause central nervous system effects such as confusion and reduction in cognitive function [1]. Polypharmacy and an increase in blood brain barrier permeability increase these effects [2] which, are more likely in the elderly [3] as aging, as well as trauma, multiple sclerosis, hypertension, stroke and diabetes [4], leads to increased blood brain barrier permeability. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - January 16, 2021 Category: OBGYN Authors: George Araklitis, Angie Rantell, Georgina Baines, Richard Flint, Dudley Robinson, Linda Cardozo Tags: Full length article Source Type: research

The Effects of Abdominal "I LOV U" Massage along with Lifestyle Training on Constipation and Distension in the Elderly with Stroke.
This study aimed to investigate the effect of abdominal massage and lifestyle training on constipation and distention of the elderly with stroke. METHOD: This study was a randomized clinical trial that was conducted on elderly patients with stroke at Qaem hospital of Mashhad, Iran. 68 patients were randomly allocated into control (n = 34) and intervention (n = 34) groups in 2017-2018. Finally 29 elderly in the intervention and 34 in the control group completed the study. Intervention included the abdominal massage by using "I LOV U" method along with lifestyle education. Each abdo...
Source: Complementary Therapies in Medicine - January 16, 2021 Category: Complementary Medicine Authors: Fekri Z, Aghebati N, Sadeghi T, Farzadfard MT Tags: Complement Ther Med Source Type: research

The effectiveness of acupoint herbal patching for functional constipation: Protocol for a meta-analysis and data mining
Conclusion: Our findings will provide evidence for the effectiveness and potential treatment prescriptions of acupoint herbal patching for patients with functional constipation. PROSPERO registration number: PROSPERO CRD 42020193489. (Source: Medicine)
Source: Medicine - January 15, 2021 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Delayed presentation of anorectal malformations in a tertiary care hospital in India
ConclusionDelayed presentation of ARMs is not uncommon and is more common in females. Management is almost similar to those who present early. Those who present with chronic constipation and megarectum require staged repair. Complications were more frequent with delayed presentation. Hence, every newborn should have careful examination of perineum and screened for ARM to avoid possible morbidity and mortality. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 15, 2021 Category: Surgery Source Type: research

IJERPH, Vol. 18, Pages 667: Exploring the Association of Autism Spectrum Disorders and Constipation through Analysis of the Gut Microbiome
Wang Over the past two decades, research into the role of the gut microbiome in regulating the central nervous system has rapidly increased. Several neurodevelopmental diseases have been linked to the unbalance of gut microbiota, including autism. Children on the autism spectrum often suffer from gastrointestinal symptoms, including constipation, which is four times more prevalent than it is in children without autism spectrum disorders (ASD). Although studies in animals have shown the crucial role of the microbiota in key aspects of neurodevelopment, there is currently no consensus on how the alteration of microbial ...
Source: International Journal of Environmental Research and Public Health - January 14, 2021 Category: Environmental Health Authors: Shih-Chen Fu Chung-Han Lee Hsiuying Wang Tags: Article Source Type: research

The Association Between Constipation and Lower Urinary Tract Symptoms in Parous Middle-Aged Women: A Prospective Cohort Study
Journal of Women's Health, Ahead of Print. (Source: Journal of Women)
Source: Journal of Women - January 12, 2021 Category: OBGYN Authors: Nour Alhababi Maria Christine Magnus Marcus John Drake Abigail Fraser Carol Joinson Source Type: research

Response to the Letter to the Editor on Celiac Disease in Children with Functional Constipation. A School Based Multicity Study.
We would like to address their disagreement with our determination to allow only children>10 years old to self-report. In their arguments, the authors ignore that our methods followed the Rome IV Committee guidelines for the use of the official questionnaire for the diagnosis of functional gastrointestinal disorders (Questionnaire on Pediatric Functional Gastrointestinal Disorders, QPGS-IV). (2) This document recommended using the self-report questionnaire in children>10 years of age (as opposed to parental report for children (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 11, 2021 Category: Pediatrics Authors: Amanda C. Fifi, Carlos Velasco-Benitez, Miguel Saps Tags: Letters to the Editor Source Type: research

Optimism for the Single-stage Transanal Swenson in Neonates
Conclusion: Transanal Swenson's procedure is feasible and can be performed safely in neonates with rectosigmoid HD with good short-term outcomes. Proper patient selection and standard protocol following fine procedural hall-marks and details are keys for optimal results and patient satisfaction. (Source: Journal of Indian Association of Pediatric Surgeons)
Source: Journal of Indian Association of Pediatric Surgeons - January 11, 2021 Category: Surgery Authors: Wesam Mohamed Mohamed I Elsawaf Aly I Shalaby Ahmed E Arafat Mahmoud M Marei Mohamed H Aboulfadl Sherif N Kaddah Gamal H El Tagy Khaled H K. Bahaaeldin Source Type: research

Deciphering the correlations between aging and constipation by metabolomics and network pharmacology.
Abstract From the points of view of phenomena and experience, aging and constipation are inextricably correlated. However, experimental support and underlying mechanisms are still lacking. The purpose of this study is to explore the relationships between aging and constipation from the perspectives of fecal metabolites and network pharmacology. The behavioral analyses of aging and constipation were carried out on both aging rats and constipation rats. We found that aging rats exhibited not only significant aging behaviors but also significant constipation behaviors, while constipation rats exhibited both significa...
Source: Aging - January 10, 2021 Category: Biomedical Science Authors: Liu X, Zhao D, Zhao S, Li Z, Wang Y, Qin X Tags: Aging (Albany NY) Source Type: research

[Blood and faecal lead levels in children with various functional gastrointestinal disorders].
Abstract INTRODUCTION: To investigate the blood lead levels (BLLs) and faecal lead levels (FLLs) in children with various functional gastrointestinal disorders (FGIDs) and compare them with controls. PATIENTS AND METHODS: One hundred and 2children with FGIDs defined by the Rome IV criteria, aged 4 -18 years, and one hundred and 2sex matched healthy children were enrolled in the study. Children with FGIDs were divided into 3subgroups as functional constipation (FC) (n=36), functional abdominal pain (FAP) (n=36) and functional náusea (FN) (n=30). The lead levels were measured using atomic absorption spec...
Source: Anales de Pediatria - January 10, 2021 Category: Pediatrics Authors: Sevinc N, Bilici N, Sevinc E, Dogan E Tags: An Pediatr (Barc) Source Type: research

Effects of sEA on Slow Transit Constipation through the Microbiota-Gut-Brain Axis in Rats.
Authors: Jin X, Guan Y, Bai H, Liu Y, Lv X Abstract To investigate the effect of sacral electroacupuncture (sEA) on the microbiota-gut-brain axis in the treatment of slow transit constipation, this study established a drug-induced model of slow transit constipation in rats and carried out sEA at the Baliao acupoints (BL31-BL34). On the 14th day of the therapeutic period (24 h fecal pellets), the aquaporin 3 (AQP3), 5-hydroxytryptamine (5-HT), and substance P (SP) transcripts from the distal colon and hypothalamus were analyzed. 16S rDNA has been widely used to analyze the diversity of the microbial communiti...
Source: Evidence-based Complementary and Alternative Medicine - January 9, 2021 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Comparative associations between anticholinergic burden and emergency department visits for anticholinergic adverse events in older Korean adults: a nested case-control study using national claims data for validation of a novel country-specific scale.
CONCLUSIONS: In conclusion, KABS is superior to pre-existing scales in identifying patients with high AB and predicting high AB-related ED visits in older Korean adults. PMID: 33413627 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - January 9, 2021 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Differences between fixed day shift workers and rotating shift workers in gastrointestinal problems: a systematic review and meta-analysis.
This study comprised a review and compilation of literature to gain an in-depth understanding of the impact of rotating shift work on gastrointestinal health. PubMed, CINAHL, and the Cochrane Library were searched for studies published between January 1, 1985, and June 30, 2020. Fixed day shifts were defined as work shifts that began between 7:00 and 9:00 in the morning. Shifts beginning at any other time were classified as rotating shifts. A meta-analysis was performed using Comprehensive Meta-Analysis Software (CMA) version 3. In the end, 16 studies were included in the meta-analysis. An odds ratio (OR) of 1.56 (95% conf...
Source: Industrial Health - January 9, 2021 Category: Occupational Health Tags: Ind Health Source Type: research

Analysis of patients ’ and caregivers’ psychosocial functioning in colorectal conditions: comparison of diagnosis, gender, and developmental functioning
ConclusionKey findings suggest that level of parental stress and behavioral concerns were significantly influenced by diagnoses, and partly by gender and presence of developmental delay. Thus, psychosocial support may need to be tailored based on these findings to provide optimum quality of care for patients and families. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 9, 2021 Category: Surgery Source Type: research

Considerations for future research on celiac disease in children with functional constipation Key Words: self-report; diagnosis
Recognition of the symptomatology associated with celiac disease will allow for earlier diagnosis and ultimately better patient outcomes. We read the report by Fifi et al and appreciate the efforts they have made to attempt to improve the early diagnosis of celiac disease (1). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 9, 2021 Category: Pediatrics Authors: Samar Al-Shamaa, Alexander Tan Tags: Letters to the Editor Source Type: research

Recurrent Hypersensitivity to Oral Low-Dose Polyethylene Glycol in a 4-year-old Child with Functional Constipation
(Source: Indian Journal of Pediatrics)
Source: Indian Journal of Pediatrics - January 8, 2021 Category: Pediatrics Source Type: research

Prophylactic Glycopyrrolate Administration to Aid Otolaryngology Residents in Prevention of Post-laryngectomy Pharyngocutaneous Fistula
AbstractPharyngocutaneous fistula (PCF) after laryngectomy occurs when there is a failure in the pharyngeal repair resulting in a salivary leak (Dedivitis et al. in Acta Otorhinolaryngol Ital 27(1):2 –5, 2007). In the post-operative period this complication is not only a challenge to the surgeon but also distressing to the patient and his family. We conducted a retrospective cum prospective study, to research the effect of starting prophylactic glycopyrrolate intravenous injection in total lar yngectomy. Fifty patients underwent total laryngectomy with modified radical neck dissection over a period of 5 years by...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - January 8, 2021 Category: ENT & OMF Source Type: research

Diagnostic and therapeutic challenges in the management of obstructive defecation.
We present the case of a 53-year-old woman with life-long constipation complicated by a solitary rectal ulcer. In these cases it is always necessary to evaluate the presence of evacuation disorder, both functional (dyssynergic defecation) and anatomical. An exhaustive clinical history and physical examination that includes a dynamic rectal examination are essential. Currently, anorectal manometry is the study of choice for functional anorectal evaluation accompanied by the balloon expulsion test. When the results of both techniques are disagreed, a third diagnostic test is required, such as defecography that will confirm t...
Source: Revista Espanola de Enfermedades Digestivas - January 7, 2021 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

Eosinophilic colitis in children: a new and elusive enemy?
ConclusionThis study focus attention on EC as a new challenging pathology. Multicentric randomized clinical trials are needed to understand physiopathological mechanisms to validate a possible endoscopic score and related histological threshold, and to standardize therapy according to clinical features and instrumental findings. The high prevalence of EC in ASD need further specific research. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - January 7, 2021 Category: Surgery Source Type: research

Dysphagia in a Cancer Patient
AbstractHypercalcemia causes gastrointestinal symptoms such as anorexia, constipation, and pancreatitis but has not been commonly associated with dysphagia. In patients with cancer, dysphagia has been attributed to local tumor invasion or as a complication from surgery, radiotherapy, and chemotherapy. However, there are cases of dysphagia in setting of malignancy with rapid resolution of symptoms after treatment of hypercalcemia. Excess calcium reduces neuromuscular excitability and leads to hypotonicity of the muscle, which could be mechanism by which dysphagia occurs. There are not enough data about dysphagia in associat...
Source: Dysphagia - January 7, 2021 Category: Speech-Language Pathology Source Type: research

Validation of the Constipation Risk Assessment Scale (CRAS) in Chinese Cancer Patients
This study aimed to translate the CRAS into Chinese and evaluate its psychometric properties in Chinese cancer patients. (Source: European Journal of Oncology Nursing)
Source: European Journal of Oncology Nursing - January 7, 2021 Category: Cancer & Oncology Authors: Xiaoxiao Ma, Qian Lu, Yuhan Lu, Wenhua Yu, Dongqin Kang, Yiyuan Zhao, Pengbo Xing, Renxiu Guo, Yun Wang Source Type: research

Doppler-guided hemorrhoidal dearterialization with laser (HeLP): indications and clinical outcome in the long-term. Results of a multicenter trial
AbstractBackgroundDoppler-guided hemorrhoidal laser procedure consists of sutureless closure of terminal branches of the superior hemorrhoidal artery by laser energy. Clinical results of patients treated with this procedure were analyzed at the completion of 2-year follow-up. Primary endpoint was resolution of symptoms and secondary endpoints were recurrence rate, type of recurrences, re-operation rate, and potential predictive factors for failure.MethodsBleeding was assessed on a score from 0 to 4 (none  = 0;   1/week = 3; 3–4/week = 4), frequency of hemorrhoid...
Source: Surgical Endoscopy - January 7, 2021 Category: Surgery Source Type: research

Validation of the Constipation Risk Assessment Scale (CRAS) in Chinese cancer patients.
This study aimed to translate the CRAS into Chinese and evaluate its psychometric properties in Chinese cancer patients. METHOD: The CRAS was translated into Chinese following standard forward- and back-translation procedures. Scale and item indices were calculated for content validity (S-CVI; I-CVI). In total, 175 cancer patients were assessed with the CRAS on the first day of antitumour treatment, of whom 145 were submitted to the predictive validity test, and their defecation pattern, stool consistency, and ease of defecation were assessed for one week. A receiver operating characteristic (ROC) curve was used to de...
Source: European Journal of Oncology Nursing - January 7, 2021 Category: Nursing Authors: Ma X, Lu Q, Lu Y, Yu W, Kang D, Zhao Y, Xing P, Guo R, Wang Y Tags: Eur J Oncol Nurs Source Type: research

The distribution and chemical coding of enteroendocrine cells in Trypanosoma cruzi -infected individuals with chagasic megacolon
In this study, we investigated the distribution and chemical coding of EEC in the dilated and non-dilated portion ofT. cruzi-induced megacolon and in non-infected individuals (control colon). Using immunohistochemistry, EECs were identified by applying antibodies to chromogranin A (CgA), glucagon-like peptide 1 (GLP-1), 5-hydroxytryptamine (5-HT), peptide YY (PYY) and somatostatin (SST). Greater numbers of EEC expressing GLP-1 and SST occurred in the dilated portion compared to the non-dilated portion of the same patients with Chagas disease and in control colon, but numbers of 5-HT and PYY EEC were not significantly diffe...
Source: Histochemistry and Cell Biology - January 6, 2021 Category: Biomedical Science Source Type: research

Herbal Formula MaZiRenWan (Hemp Seed Pill) for Constipation: A Systematic Review with Meta-analysis
Publication date: Available online 5 January 2021Source: PhytomedicineAuthor(s): Mingxiao Yang, Ye Feng, Yi Lily Zhang, Colleen M. Smith, Yen-Nien Hou, Hui Wang, Gary Deng, Jun J. Mao (Source: Phytomedicine)
Source: Phytomedicine - January 5, 2021 Category: Drugs & Pharmacology Source Type: research

Frequency of Bowel Movements and Risk of Diverticulitis
The etiology of diverticulitis is poorly understood. The long-held belief that constipation and low-fiber diet are risk factors for diverticulosis has recently been challenged by studies that suggest that more frequent bowel movements predispose to diverticulosis. We aim to prospectively explore the association between bowel movement frequency and incident diverticulitis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 5, 2021 Category: Gastroenterology Authors: Manol Jovani, Wenjie Ma, Kyle Staller, Amit D. Joshi, Po-Hong Liu, Long H. Nguyen, Paul Lochhead, Yin Cao, Idy Tam, Kana Wu, Edward L. Giovannucci, Lisa L. Strate, Andrew T. Chan Source Type: research

Is Gut Dysbiosis an Epicenter of Parkinson's Disease?
Abstract Once recognized as one of the most esoteric diseases of the central nervous system, Parkinson's disease (PD) is now deemed to be a chronic illness contributed by the central, autonomic and enteric nervous systems. Most likely, an accumulation of α-synuclein in the central and enteric nervous systems is the key that supports this viewpoint. Constipation, one of the non-motor hallmarks in roughly two-third of PD patients, is regulated by the composition of gut bacteria, which is assumed to set off the enteric α-synuclein accrual. Vagus nerve is suggested to direct the signal for α-synuclei...
Source: Neurochemical Research - January 5, 2021 Category: Neuroscience Authors: Rajput C, Sarkar A, Sachan N, Rawat N, Singh MP Tags: Neurochem Res Source Type: research

Deciphering the Role of Human Gastrointestinal Microbiota in the Pathogenesis of Vaginal Infection and Cervical Cancer.
Authors: Wang J, Yang Z, Li W Abstract The human microbiota typically contains symbionts and supports the host, although it can be commensal or reciprocal and pathogenic in its host function, immunity, and diet. Modern studies indicate that perturbations in the microbiome may be present in quite a few diseases, including inflammation and cancer. To be more specific, changes in the microbiomes of the gut and vagina may be related to various gynecologic cancers (cervical, uterine, and ovarian). Furthermore, the gastrointestinal microbiota can be altered by environmental factors and pre-existing morbidities and may ca...
Source: Journal of Environmental Pathology, Toxicology and Oncology - January 4, 2021 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Multicenter investigation of bowel evacuation function after transanal total mesorectal excision for mid-low rectal cancer
ConclusionsThe bowel evacuation function after taTME is acceptable. Perioperative chemoradiotherapy, anastomotic method, and preoperative constipation are factors associated with bowel dysfunction after taTME. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - January 3, 2021 Category: Gastroenterology Source Type: research

A phase 1 pharmacokinetic study of oral NEPA, the fixed combination of netupitant and palonosetron, in Chinese healthy volunteers
ConclusionFollowing single-dose administration of oral NEPA in Chinese subjects, the pharmacokinetic profiles of the NEPA components were mostly similar to those reported previously in Caucasians. NEPA was well tolerated with a safety profile in line with that observed in pivotal trials in Caucasians. (Source: Cancer Chemotherapy and Pharmacology)
Source: Cancer Chemotherapy and Pharmacology - January 2, 2021 Category: Cancer & Oncology Source Type: research

Advantages of robotic surgery in the treatment of complex pelvic organs prolapse
AbstractRobot-assisted surgery is safe and effective to treat the complex pelvic organs prolapse (C-POP). The present study analyzes all the robotic procedures and their advantages in the treatment of C-POP performed in a Proctologic and Pelvic Floor Clinical Centre. All the patients affected by C-POP who had robot-assisted surgery were retrospective analyzed. The anatomical and functional outcomes were respectively evaluated through POP-Q grading system and Wexner score about constipation and incontinence. The satisfaction rate was investigated using a five-point scale. From September 2014 to December 2018, 229 women unde...
Source: Updates in Surgery - January 2, 2021 Category: Surgery Source Type: research

Delphi consensus on strategies in the management of opioid-induced constipation in cancer patients
Opioid-induced constipation (OIC) is a frequent and bothersome adverse event related with opioid therapy in cancer patients. Despite the high prevalence, medical management of OIC is often uncertain. The curre... (Source: BMC Palliative Care)
Source: BMC Palliative Care - January 2, 2021 Category: Palliative Care Authors: Regina Giron és Sarrió, Agnès Calsina-Berna, Adoración Gozalvo García, José Miguel Esparza-Miñana, Esther Falcó Ferrer and Josep Porta-Sales Tags: Research article Source Type: research

Constipation in Hospitalized Patients: A Study of Prevalence and Associated Factors
CONCLUSION: The prevalence of constipation in hospitalized adult patients was lower than that in previous studies. Patients using laxatives were more likely to experience constipation. (Source: Journal of Wound, Ostomy and Continence Nursing)
Source: Journal of Wound, Ostomy and Continence Nursing - January 1, 2021 Category: Nursing Tags: Continence Care Source Type: research

Context for Practice: Unavoidable Pressure Injury, Constipation, Peripheral Intravenous Catheter Extravasation in Neonates and Other Hot Topics
No abstract available (Source: Journal of Wound, Ostomy and Continence Nursing)
Source: Journal of Wound, Ostomy and Continence Nursing - January 1, 2021 Category: Nursing Tags: Editorial Source Type: research

Aster tataricus alleviates constipation by antagonizing the binding of acetylcholine to muscarinic receptor and inhibiting Ca2+ influx.
CONCLUSIONS: Taking all these findings together, it could be speculated that ATE may attenuate constipation mainly through antagonizing the binding of acetylcholine to muscarinic receptor, inhibiting Ca2+ influx and anti-inflammation. PMID: 33378996 [PubMed - in process] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 1, 2021 Category: Drugs & Pharmacology Authors: Wu H, Chen Y, Huang B, Yu Y, Zhao S, Liu J, Jia Z, Xiao H Tags: Biomed Pharmacother Source Type: research