Fatal acute graft-versus-host disease in Sezary Syndrome treated with Mogamulizumab and hematopoietic cell transplantation
This report describes the case of a 37-year-old man with advanced SS who received mogamulizumab therapy followed by allo-HCT from an HLA-identical sibling donor. The patient developed severe gastrointestinal acute GvHD, which was treated with steroids and infliximab. However, the condition rapidly progressed to severe intestinal symptoms and life-threatening haemorrhagic shock, ultimately resulting in the patient's death. This case highlights a potential link between mogamulizumab and severe acute GvHD promoted by drug-induced suppression of regulatory T cells. Further research is required to fully understand the interacti...
Source: Cell Research - May 8, 2024 Category: Cytology Authors: Gentiana Elena Trotta Giulia Ciangola Ilaria Cerroni Valeria Mezzanotte Andrea Nunzi Lucia Anemona Luca Savino Gottardo De Angelis Benedetta Mariotti Fabrizio Bonanni Elisa Meddi Annagiulia Zizzari Vito Mario Rapisarda Ilaria Mangione Antonio Bruno Maria Source Type: research
Susceptibility of mouse cochlear hair cells to cisplatin ototoxicity largely depends on sensory mechanoelectrical transduction channels both Ex Vivo and In Vivo
This study aimed to investigate the entry route of cisplatin into mouse cochlear hair cells. The competitive inhibitor of organic cation transporter 2 (OCT2), cimetidine, and the sensory mechanoelectrical transduction (MET) channel blocker benzamil, demonstrated a protective effect against cisplatin toxicity in hair cells in cochlear explants. Sensory MET-deficient hair cells explanted from Tmc1Δ;Tmc2Δ mice were resistant to cisplatin toxicity. Cimetidine showed an additive protective effect against cisplatin toxicity in sensory MET-deficient hair cells. However, in the apical turn, cimetidine, benzamil, or genetic ablat...
Source: Cell Research - May 8, 2024 Category: Cytology Authors: Ayako Maruyama Yoshiyuki Kawashima Yoko Fukunaga Ayane Makabe Ayako Nishio Takeshi Tsutsumi Source Type: research
Histone deacetylase as emerging pharmacological therapeutic target for neuropathic pain: From epigenetic to selective drugs
CONCLUSIONS: Abnormally elevated HDACs promote neuronal excitability and neuroinflammation by epigenetically modulating pivotal gene expression in neuronal and immune cells, contributing to peripheral and central sensitization in the progression of neuropathic pain, and HDACi showed significant efficacy and great potential for alleviating neuropathic pain.PMID:38715326 | DOI:10.1111/cns.14745 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 8, 2024 Category: Neuroscience Authors: Wencui Zhang Bo Jiao Shangchen Yu Caixia Zhang Kaiwen Zhang Baowen Liu Xianwei Zhang Source Type: research
Plant-assisted green preparation of silver nanoparticles using leaf extract of Dalbergia sissoo and their antioxidant, antibacterial and catalytic applications
Bioprocess Biosyst Eng. 2024 May 9. doi: 10.1007/s00449-024-03029-w. Online ahead of print.ABSTRACTPlant-mediated preparation of silver nanoparticles (AgNPs) is thought to be a more economical and environmentally benign process in comparison to physical and chemical synthesis methods. In the present study, the aqueous leaf extract of Dalbergia sissoo was prepared and utilized to reduce silver ion (Ag+) during the green synthesis of silver nanoparticles (DL-AgNPs). The formation of DL-AgNPs was verified using UV-Vis spectra, exhibiting the surface plasmon resonance (SPR) band at around 450 nm. FT-IR analysis revealed the ki...
Source: Bioprocess and Biosystems Engineering - May 8, 2024 Category: Biomedical Engineering Authors: Hamida Khatun Shahin Alam Md Abdul Aziz Md Rezaul Karim Md Habibur Rahman M Ahasanur Rabbi Md Rowshanul Habib Source Type: research
Susceptibility of mouse cochlear hair cells to cisplatin ototoxicity largely depends on sensory mechanoelectrical transduction channels both Ex Vivo and In Vivo
This study aimed to investigate the entry route of cisplatin into mouse cochlear hair cells. The competitive inhibitor of organic cation transporter 2 (OCT2), cimetidine, and the sensory mechanoelectrical transduction (MET) channel blocker benzamil, demonstrated a protective effect against cisplatin toxicity in hair cells in cochlear explants. Sensory MET-deficient hair cells explanted from Tmc1Δ;Tmc2Δ mice were resistant to cisplatin toxicity. Cimetidine showed an additive protective effect against cisplatin toxicity in sensory MET-deficient hair cells. However, in the apical turn, cimetidine, benzamil, or genetic ablat...
Source: Hearing Research - May 8, 2024 Category: Audiology Authors: Ayako Maruyama Yoshiyuki Kawashima Yoko Fukunaga Ayane Makabe Ayako Nishio Takeshi Tsutsumi Source Type: research
Overview of systematic toxicological analysis strategies and their coverage of substances in forensic toxicology
Anal Sci Adv. 2023 Apr 15;4(3-4):96-103. doi: 10.1002/ansa.202200062. eCollection 2023 May.ABSTRACTSystematic toxicological analysis (STA) is the process of using an adequate analytical methodology to detect and identify as many potentially toxicologically relevant compounds as possible in biological samples. STA is an important part of everyday routine work within forensic toxicology, and several methods for STA have frequently been published and reviewed independently. However, the many drugs and other substances involved, as well as the constant emergence of new ones, may pose a major challenge in STA, which often deman...
Source: Anal Sci - May 8, 2024 Category: Chemistry Authors: Karen Rygaard Meiru Pan Marie Katrine Klose Nielsen Petur Weihe Dalsgaard Brian Schou Rasmussen Kristian Linnet Source Type: research
RIFM fragrance ingredient safety assessment, 2-methyl-4-phenyl-2-butanol, CAS Registry Number 103-05-9
Food Chem Toxicol. 2024 May 6:114712. doi: 10.1016/j.fct.2024.114712. Online ahead of print.NO ABSTRACTPMID:38718914 | DOI:10.1016/j.fct.2024.114712 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - May 8, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Enzyme-Activatable Near-Infrared Hemicyanines as Modular Scaffolds for in vivo Photodynamic Therapy
Angew Chem Int Ed Engl. 2024 May 8:e202404587. doi: 10.1002/anie.202404587. Online ahead of print.ABSTRACTPhotodynamic therapy is an anti-cancer treatment that requires illumination of photosensitizers to induce local cell death. Current near-infrared organic photosensitizers are built from large and non-modular structures that cannot be tuned to improve safety and minimize off-target toxicity. This work describes a novel chemical platform to generate enzyme-activatable near-infrared photosensitizers. We optimized the Se-bridged hemicyanine scaffold to include caging groups and biocompatible moieties, and generated catheps...
Source: Angewandte Chemie - May 8, 2024 Category: Chemistry Authors: Zhiming Cheng Sam Benson Lorena Mendive-Tapia Eleni Nestoros Charles Lochenie Deborah Seah Kai Yee Chang Yi Feng Marc Vendrell Source Type: research
Fisetin from Dietary Supplement to a Drug Candidate: An Assessment of Potential - A Review
Curr Pharm Biotechnol. 2024 Apr 22. doi: 10.2174/0113892010304479240415074928. Online ahead of print.ABSTRACTFisetin is a bioactive compound found in numerous fruits and vegetables, including strawberries, apples, grapes, persimmon, cucumber, onion, etc. The compound is also wellknown for its neurotrophic, anti-inflammatory, anti-carcinogenic, anti-diabetic, and other healthpromoting properties. Although there is increasing agreement that it has therapeutic properties, its poor water solubility, high lipophilicity, and lower oral bioavailability make it difficult to use clinically. Extensive research has attempted to overc...
Source: Current Pharmaceutical Biotechnology - May 8, 2024 Category: Biotechnology Authors: Mohd Aamir Mirza Santwana Padhi Sradhanjali Mohapatra Syed Mahmood Zeenat Iqbal Source Type: research
Nanotechnology Integrated Innovative Drug Delivery and Therapy for Cancer
Curr Pharm Biotechnol. 2024 Apr 22. doi: 10.2174/0113892010279483240417050548. Online ahead of print.ABSTRACTCancer remains a significant global health challenge, necessitating innovative approaches to enhance the efficacy and specificity of therapeutic interventions while minimizing adverse effects on healthy tissues. Nanotechnology has emerged as a promising avenue in cancer treatment, offering novel strategies for targeted drug delivery. Nanoparticles, liposomes, and polymer-based systems have played pivotal roles in revolutionizing cancer therapy. Nanotechnology possesses unique physicochemical properties, enabling eff...
Source: Current Pharmaceutical Biotechnology - May 8, 2024 Category: Biotechnology Authors: Romulo R Macadangdang Rutvi Agrawal Bharat Bhushan Akash Garg Kuldeep Singh Shivendra Kumar Atul Kumar Source Type: research
Isolation and characterization of two Staphylococcus aureus lytic bacteriophages "Huma" and "Simurgh"
Virology. 2024 May 1;595:110090. doi: 10.1016/j.virol.2024.110090. Online ahead of print.ABSTRACTNowadays finding the new antimicrobials is necessary due to the emerging of multidrug resistant strains. The present study aimed to isolate and characterize bacteriophages against S. aureus. Strains Huma and Simurgh were the two podovirus morphology phages which isolated and then characterized. Huma and Simurgh had a genome size of 16,853 and 17,245 bp, respectively and both were Rosenblumvirus with G + C content of 29%. No lysogeny-related genes, nor virulence genes were identified in their genomes. They were lytic only agains...
Source: Virology - May 8, 2024 Category: Virology Authors: Fatemeh Sharifi Maryam Montaseri Mohammad Hashem Yousefi Seyed Shahram Shekarforoush Enayat Berizi Jeroen Wagemans Marta Vallino Saeid Hosseinzadeh Source Type: research
Computational investigation of 2, 4-Di Tert Butyl Phenol as alpha amylase inhibitor isolated from Coccinia grandis (L.) Voigt using molecular docking, and ADMET parameters
CONCLUSION: The data suggested that the isolated compound (2, 4-tertiary butyl phenol) has the potential to inhibit the alpha-amylase activity and possess optimal ADME properties as well as tolerable side effects.PMID:38718496 | DOI:10.1016/j.compbiolchem.2024.108087 (Source: Computational Biology and Chemistry)
Source: Computational Biology and Chemistry - May 8, 2024 Category: Bioinformatics Authors: Yasmin H Momin V C Yeligar M G Saralaya G Dharmamoorthy B P Mallikarjuna S T Jadhav Kuntal Das Mansour Almuqbil Fuzail Ahmad Syed Imam Rabbani Syed Mohammed Basheeruddin Asdaq Source Type: research
Advances in pharmacotherapies for cytomegalovirus infection: what is the current state of play?
Expert Opin Pharmacother. 2024 May 8. doi: 10.1080/14656566.2024.2353627. Online ahead of print.ABSTRACTINTRODUCTION: Cytomegalovirus (CMV) remains a serious opportunistic infection in hematopoietic cell transplant (HCT) and solid-organ transplant (SOT) recipients. Traditional anti-CMV drugs are limited by toxicities and the development of resistance. Letermovir and maribavir are newly approved antivirals for the prevention and treatment of CMV.AREAS COVERED: Prior reviews have discussed use of letermovir for prevention of CMV after HCT and maribavir for resistant or refractory (R/R) CMV post HCT or SOT. Subsequent data ha...
Source: Expert Opinion on Pharmacotherapy - May 8, 2024 Category: Drugs & Pharmacology Authors: Lea M Monday Vishakh Keri Pranatharthi H Chandrasekar Source Type: research
Combattre la toxicit é financière associée aux soins contre le cancer au Canada
CMAJ. 2024 May 5;196(17):E612-E614. doi: 10.1503/cmaj.230677-f.NO ABSTRACTPMID:38719219 | DOI:10.1503/cmaj.230677-f (Source: Canadian Medical Association Journal)
Source: Canadian Medical Association Journal - May 8, 2024 Category: General Medicine Authors: Truman F Wood Rachel A Murphy Source Type: research
Potential antiprostatic performance of novel lanthanide-complexes based on 5-nitropicolinic acid
J Biol Inorg Chem. 2024 May 8. doi: 10.1007/s00775-024-02054-0. Online ahead of print.ABSTRACTTwo new lanthanide-complexes based on the 5-nitropicolinate ligand (5-npic) were obtained and fully characterized. Single-crystal X-ray diffraction revealed that these compounds are isostructural to a Dy-complex, previously published by us, based on dinuclear monomers link together with an extended hydrogen bond network, providing a final chemical formula of [Ln2(5-npic)6(H2O)4]·(H2O)2, where Ln = Dy (1), Gd (2), and Tb (3). Preliminary photoluminescent studies exhibited a ligand-centered emission for all complexes. The potential...
Source: Journal of Biological Inorganic Chemistry : JBIC - May 8, 2024 Category: Chemistry Authors: Amalia Garc ía-García Pablo Cristobal-Cueto Tania Hidalgo I ñigo J Vitórica-Yrezábal Antonio Rodr íguez-Diéguez Patricia Horcajada Sara Rojas Source Type: research
