A new agent for contrast-enhanced intravascular ultrasound imaging in vitro: polybutylcyanoacrylate nanoparticles with drug-carrying capacity
This study prepared and evaluated polymeric polybutylcyanoacrylate (PBCA) nanoparticles (NPs) that can be used as a new agent for contrast-enhanced intravascular ultrasound (IVUS) imaging with drug delivery capacity. The nanoformulation was successfully developed using suspension polymerisation and characterised in terms of size, size distribution, zeta potential, morphology, stability, toxicity effects, imaging effects and drug release study. The results showed that the nanoparticles were round and hollow, with a particle diameter of 215.8 ± 25.3 nm and a zeta potential of -22.2 ± 4.1 mV. In vitro experiments, the nanop...
Source: Artificial Cells, Nanomedicine and Biotechnology - April 22, 2024 Category: Biotechnology Authors: Congying Wang Haodong Jiang Jia Zhu Yunpeng Jin Source Type: research
Blocking group 2 innate lymphoid cell activation and macrophage M2 polarization: potential therapeutic mechanisms in ovalbumin-induced allergic asthma by calycosin
CONCLUSIONS: Collectively, this study showed that calycosin might attenuate OVA-induced airway inflammation and remodeling in asthmatic mice via preventing ILC2 activation and macrophage M2 polarization. Our study might contribute to further study of asthmatic therapy.PMID:38650035 | DOI:10.1186/s40360-024-00751-9 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - April 22, 2024 Category: Drugs & Pharmacology Authors: Chunyan Tian Qi Liu Xiaoyu Zhang Zhuying Li Source Type: research
Antibody-drug conjugates in lung and breast cancer: Current evidence and future directions - a position statement from the ETOP IBCSG Partners Foundation
Ann Oncol. 2024 Apr 20:S0923-7534(24)00108-X. doi: 10.1016/j.annonc.2024.04.002. Online ahead of print.ABSTRACTFollowing the approval of the first antibody-drug conjugates (ADCs) in the early 2000s, development has increased dramatically, with 14 ADCs now approved and >100 in clinical development. In lung cancer, trastuzumab deruxtecan (T-DXd) is approved in human epidermal growth factor receptor 2 (HER2)-mutated, unresectable or metastatic non-small cell lung cancer, with ADCs targeting HER3 (patritumab deruxtecan), trophoblast cell-surface antigen 2 (datopotamab deruxtecan and sacituzumab govitecan [SG]) and mesenchym...
Source: Ann Oncol - April 22, 2024 Category: Cancer & Oncology Authors: S Peters S Loi F Andr é S Chandarlapaty E Felip S P Finn P A J änne K M Kerr E Munzone A Passaro M P érol E F Smit C Swanton G Viale R A Stahel Source Type: research
Gender Difference in sidE eFfects of ImmuNotherapy: a possible clue to optimize cancEr tReatment (G-DEFINER): study protocol of an observational prospective multicenter study
Acta Oncol. 2024 Apr 21;63:213-219. doi: 10.2340/1651-226X.2024.24179.ABSTRACTBACKGROUND: Immune checkpoint inhibitors (ICIs) have significantly improved outcomes in various cancers. ICI treatment is associated with the incidence of immune-related adverse events (irAEs) which can affect any organ. Data on irAEs occurrence in relation to sex- differentiation and their association with gender-specific factors are limited.AIMS: The primary objective of the G-DEFINER study is to compare the irAEs incidence in female and male patients who undergo ICI treatment. Secondary objectives are: to compare the irAEs incidence in pre- an...
Source: Acta Oncologica - April 22, 2024 Category: Cancer & Oncology Authors: Rosalba Miceli Hanna Eriksson Giuseppe Lo Russo Salvatore Alfieri Maria Moksnes Bjaan æs Filippo Pietrantonio Loris De Cecco Arsela Prelaj Claudia Proto Johan Franz én Deirdre McDonnell Jos é Javier Berenguer Pina Teresa Beninato Laura Mazzeo Patrizia Source Type: research
Efficacy and safety of tislelizumab plus lenvatinib as first-line treatment in patients with unresectable hepatocellular carcinoma: a multicenter, single-arm, phase 2 trial
CONCLUSIONS: Tislelizumab plus lenvatinib demonstrated promising antitumor activity with favourable tolerability as first-line therapy for patients with uHCC.TRIAL REGISTRATION: ClinicalTrials.gov (NCT04401800).PMID:38650037 | DOI:10.1186/s12916-024-03356-5 (Source: Cancer Control)
Source: Cancer Control - April 22, 2024 Category: Cancer & Oncology Authors: Li Xu Jinzhang Chen Chang Liu Xiaoling Song Yanqiao Zhang Haitao Zhao Sheng Yan Weidong Jia Zheng Wu Yabing Guo Jiayin Yang Wei Gong Yue Ma Xiaobo Yang Zhenzhen Gao Nu Zhang Xin Zheng Mengyu Li Dan Su Minshan Chen Source Type: research
A new agent for contrast-enhanced intravascular ultrasound imaging in vitro: polybutylcyanoacrylate nanoparticles with drug-carrying capacity
This study prepared and evaluated polymeric polybutylcyanoacrylate (PBCA) nanoparticles (NPs) that can be used as a new agent for contrast-enhanced intravascular ultrasound (IVUS) imaging with drug delivery capacity. The nanoformulation was successfully developed using suspension polymerisation and characterised in terms of size, size distribution, zeta potential, morphology, stability, toxicity effects, imaging effects and drug release study. The results showed that the nanoparticles were round and hollow, with a particle diameter of 215.8 ± 25.3 nm and a zeta potential of -22.2 ± 4.1 mV. In vitro experiments, the nanop...
Source: Atherosclerosis - April 22, 2024 Category: Cardiology Authors: Congying Wang Haodong Jiang Jia Zhu Yunpeng Jin Source Type: research
Predictive significance of FGFR4 p.G388R polymorphism in metastatic colorectal cancer patients receiving trifluridine/tipiracil (TAS-102) treatment
CONCLUSIONS: This phenotype/genotype investigation suggests that the FGFR4 p.G388R variant may serve as a new marker for identifying patients who are responsive to TAS-102. A mechanistic hypothesis is proposed to interpret these findings.PMID:38650006 | DOI:10.1186/s12967-024-05184-w (Source: Cancer Control)
Source: Cancer Control - April 22, 2024 Category: Cancer & Oncology Authors: Alessandro Ottaiano Mariachiara Santorsola Monica Ianniello Anna Ceccarelli Marika Casillo Francesco Sabbatino Nadia Petrillo Marco Cascella Francesco Caraglia Carmine Picone Francesco Perri Roberto Sirica Silvia Zappavigna Guglielmo Nasti Giovanni Savare Source Type: research
N-acetylcysteine Protects Against Myocardial Ischemia-Reperfusion Injury Through Anti-ferroptosis in Type 1 Diabetic Mice
Cardiovasc Toxicol. 2024 Apr 22. doi: 10.1007/s12012-024-09852-7. Online ahead of print.ABSTRACTThe hearts of subjects with diabetes are vulnerable to ischemia-reperfusion injury (IRI). In contrast, experimentally rodent hearts have been shown to be more resistant to IRI at the very early stages of diabetes induction than the heart of the non-diabetic control mice, and the mechanism is largely unclear. Ferroptosis has recently been shown to play an important role in myocardial IRI including that in diabetes, while the specific mechanisms are still unclear. Non-diabetic control (NC) and streptozotocin-induced diabetic (DM) ...
Source: Cardiovascular Toxicology - April 22, 2024 Category: Cardiology Authors: Dongcheng Zhou Yuhui Yang Jiajia Chen Jiaqi Zhou Jianfeng He Danyong Liu Anyuan Zhang Bixian Yuan Yuxin Jiang Weiyi Xia Ronghui Han Zhengyuan Xia Source Type: research
Carrageenan maintains the contractile phenotype of vascular smooth muscle cells by increasing macromolecular crowding in vitro
CONCLUSIONS: The in vitro study showed that VSMCs can maintain the contractile phenotype by sensing changes in the crowding of the culture environment, which can be maintained by adding CR.PMID:38650027 | DOI:10.1186/s40001-024-01843-2 (Source: Cell Research)
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Qing Liu Hong-Jing Jiang Yin-Di Wu Jian-Dong Li Xu-Heng Sun Cong Xiao Jian-Yi Xu Zhan-Yi Lin Source Type: research
admetSAR3.0: a comprehensive platform for exploration, prediction and optimization of chemical ADMET properties
Nucleic Acids Res. 2024 Apr 22:gkae298. doi: 10.1093/nar/gkae298. Online ahead of print.ABSTRACTAbsorption, distribution, metabolism, excretion and toxicity (ADMET) properties play a crucial role in drug discovery and chemical safety assessment. Built on the achievements of admetSAR and its successor, admetSAR2.0, this paper introduced the new version of the series, admetSAR3.0, as a comprehensive platform for chemical ADMET assessment, including search, prediction and optimization modules. In the search module, admetSAR3.0 hosted over 370 000 high-quality experimental ADMET data for 104 652 unique compounds, and supplemen...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Yaxin Gu Zhuohang Yu Yimeng Wang Long Chen Chaofeng Lou Chen Yang Weihua Li Guixia Liu Yun Tang Source Type: research
Chronic exposure to Zearalenone leads to endometrial hyperplasia in CD-1 mice by altering the inflammatory markers
CONCLUSION: Our finding conclude that ZEA targets the uterus and cause inflammation due to increased levels of inflammatory cytokines and proliferation mediators, as well as systemic toxicity denoted by a strong binding affinity with serum proteins.PMID:38645625 | PMC:PMC11031408 | DOI:10.1093/toxres/tfae055 (Source: Cell Research)
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Varsha Singh Payal Mandal Shweta Singh Chauhan Ishrat Jahan Saifi None Marhaba P V Sandeep Pankaj Jagdale Anjaneya Ayanur Kausar Mahmood Ansari Source Type: research
Development of natural dye photosensitizers for dye-sensitized solar cells: a review
Environ Sci Pollut Res Int. 2024 Apr 22. doi: 10.1007/s11356-024-33360-4. Online ahead of print.ABSTRACTDye-sensitized solar cell (DSSC) is a photovoltaic device that can be produced from natural source pigments or natural dyes. The selection of natural dyes for DSSC application is currently under research. The utilization of natural dye materials that are easy to obtain, cost-effective, and non-toxic can reduce waste during DSSC fabrication. Natural dyes can be extracted from plants through extraction and chromatography methods. The suitability and viability of utilizing natural dyes as photosensitizers in DSSCs can be pr...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Aripin Triyanto Nora'aini Ali Hasiah Salleh Jan Setiawan Norhafiza I Yatim Source Type: research
A new benzoquinone and a new stilbenoid from < em > Paphiopedilum exul < /em > (Ridl.) Rolfe
Nat Prod Res. 2024 Apr 22:1-9. doi: 10.1080/14786419.2024.2344196. Online ahead of print.ABSTRACTOne new alkyl benzoquinone, paphionone (1), one new trans-stilbenoid, (E)-6,5'-dihydroxy-2,3'-dimethoxystilbene (2), and eight known stilbenoids and flavonoids (3-10) were isolated from the leaves and roots of Paphiopedilum exul (Orchidaceae). Their chemical structures were determined based on IR, ECD, MS and NMR analyses. Cytotoxicity of all isolated compounds towards human hepatocellular carcinoma (HepG2) cell line was examined in vitro by MTT assay. The para-hydroxybenzyl substituted stilbene 10 was potently cytotoxic to the...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Nonthalert Lertnitikul Ladawan Teerasukpimol Pattatorn Aekanantakul Naphatsawan Pooreecharurot Suchada Sukrong Cherdsak Boonyong Preeyaporn Poldorn Thanyada Rungrotmongkol Edwin Risky Sukandar Chanat Aonbangkhen Rutt Suttisri Source Type: research
Multienzyme ‐Like Polyoxometalate‐Based Single‐Atom Enzymes for Cancer‐Specific Therapy Through Acid‐Triggered Nontoxicity‐to‐Toxicity Transition
This study provides a detailed investigation on the acid-triggered releasing of active units and the electron transfer in multienzyme-mimic-like therapy, further enlarging the application of POMs from catalytical engineering into cancer therapy. (Source: Small)
Source: Small - April 22, 2024 Category: Nanotechnology Authors: Xiyang Ge,
Yiyan Yin,
Xiaoni Wang,
Yixuan Gao,
Xiaowen Guan,
Jianghui Sun,
Jin Ouyang,
Na Na Tags: Research Article Source Type: research
Circ_0000277 promotes the malignant progression of oesophageal squamous cell carcinoma through miR-1294-dependent regulation of DVL3
ConclusionCirc_0000277 promoted ESCC malignant progression through the miR-1294/DVL3 pathway.HighlightsCirc_0000277 expression was upregulated in ESCC tissues and cells.Circ_0000277 contributed to ESCC cell proliferation, migration and invasion.Circ_0000277 induced DVL3 expression through sponging miR-1294. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 22, 2024 Category: Cytology Source Type: research
