Two cases of diquat poisoning in adolescent children
Diquat (DQ) is among the most widely used herbicides, and its intake can cause severe systemic toxicity that manifests rapidly. The resultant symptoms can cause the dysfunction of a range of tissues and organs... (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - April 22, 2024 Category: Pediatrics Authors: Mengtao Duan, Baowang Yang, Xiaohang Cheng, Fuhui Shen, Xia Lu and Fan Wang Tags: Case report Source Type: research
Involved-field radiotherapy in older patients with superficial thoracic esophageal squamous cell carcinoma: long-term outcomes and recurrence patterns
ConclusionsThe efficacy of IFRT was suggested to be comparable to that of standard treatments. Therefore, IFRT can be a promising approach for treating superficial ESCC in older adults, especially those with severe comorbidities. (Source: Japanese Journal of Radiology)
Source: Japanese Journal of Radiology - April 22, 2024 Category: Radiology Source Type: research
A deep learning-based method for the prediction of temporal lobe injury in patients with nasopharyngeal carcinoma
Radiotherapy (RT) is the primary treatment modality for nasopharyngeal carcinoma (NPC) and demonstrates a satisfactory 5-year overall survival [1]. However, the emergence of radiation-induced complications or late RT toxicities cannot be overlooked [2]. Temporal lobe injury (TLI) induced by radiotherapy is a severe late sequela that typically manifests 6 –47 months post-treatment, leading to symptoms such as dizziness, memory loss, personality changes, cognitive impairment, temporal lobe epilepsy, or necrosis. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - April 22, 2024 Category: General Medicine Authors: Wenting Ren, Bin Liang, Chao Sun, Runye Wu, Kuo Men, Huan Chen, Xin Feng, Lu Hou, Fei Han, Junlin Yi, Jianrong Dai Tags: Original paper Source Type: research
RCEM best practice guideline: suspected cannabinoid hyperemesis syndrome in emergency departments
Cannabinoid hyperemesis syndrome (CHS) is an episodic syndrome of cyclic vomiting in the context of the prolonged use of cannabis. The Royal College of Emergency Medicine Toxicology Special Interest Group has produced guidance to support emergency medicine clinicians with the recognition and treatment of people experiencing CHS.
Considerations regarding recognition, investigation and communication are discussed, and recommendations regarding treatment options (which include haloperidol and capsaicin) are made. There is a focus on making recommendations on the best available evidence. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - April 22, 2024 Category: Emergency Medicine Authors: Humphries, C., Gillings, M. Tags: Practice review Source Type: research
Viruses, Vol. 16, Pages 651: Why Certain Repurposed Drugs Are Unlikely to Be Effective Antivirals to Treat SARS-CoV-2 Infections
vanziam
Raymond F. Schinazi
Most repurposed drugs have proved ineffective for treating COVID-19. We evaluated median effective and toxic concentrations (EC50, CC50) of 49 drugs, mostly from previous clinical trials, in Vero cells. Ratios of reported unbound peak plasma concentrations, (Cmax)/EC50, were used to predict the potential in vivo efficacy. The 20 drugs with the highest ratios were retested in human Calu-3 and Caco-2 cells, and their CC50 was determined in an expanded panel of cell lines. Many of the 20 drugs with the highest ratios were inactive in human Calu-3 and Caco-2 cells. Antivirals effective in cont...
Source: Viruses - April 22, 2024 Category: Virology Authors: Selwyn J. Hurwitz Ramyani De Julia C. LeCher Jessica A. Downs-Bowen Shu Ling Goh Keivan Zandi Tamara McBrayer Franck Amblard Dharmeshkumar J. Patel James J. Kohler Manoj Bhasin Brian S. Dobosh Vikas Sukhatme Rabindra M. Tirouvanziam Raymond F. Schinazi Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1605: Immune Therapies in AL Amyloidosis & mdash;A Glimpse to the Future
Cancers, Vol. 16, Pages 1605: Immune Therapies in AL Amyloidosis—A Glimpse to the Future
Cancers doi: 10.3390/cancers16081605
Authors:
Arnon Haran
Iuliana Vaxman
Moshe E. Gatt
Eyal Lebel
Light-chain (AL) amyloidosis is a rare plasma cell disorder characterized by the deposition of misfolded immunoglobulin light chains in target organs, leading to multi-organ dysfunction. Treatment approaches have historically mirrored but lagged behind those of multiple myeloma (MM). Recent advancements in MM immunotherapy are gradually being evaluated and adopted in AL amyloidosis. This review explores the current ...
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Arnon Haran Iuliana Vaxman Moshe E. Gatt Eyal Lebel Tags: Review Source Type: research
Toxicological implications of storage conditions on yeast vacuole properties and activities
ConclusionThese findings underscore the importance of appropriate storage methods for vacuoles, particularly in the context of their potential as valuable materials that efficiently harness their antibacterial and anticancer properties, while also shedding light on their toxicological implications in the field of cellular toxicology. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 22, 2024 Category: Cytology Source Type: research
An in vitro study of metformin adsorption to activated charcoal
. (Source: Clinical Toxicology)
Source: Clinical Toxicology - April 22, 2024 Category: Toxicology Authors: Yoshinori TomodaMasahiro KobayashiLaboratory of Clinical Pharmacokinetics, Research and Education Center for Clinical Pharmacy, Kitasato University School of Pharmacy, Tokyo, Japan Source Type: research
Two cases of diquat poisoning in adolescent children
In this report, we compare two similar cases of juvenile diquat poisoning with dynamic changes in clinical manifestations, laboratory values, and imaging results. For the first time, the difference in whether to perform blood flow perfusion and the time difference of initiation of hemoperfusion had a clear clinical difference in the subsequent effects of diquat poisoning in children with diquat poisoning. Limited evidence is available regarding the efficacy of early hemoperfusion for diquat poisoning; however, the differences in clinical outcomes articulated here highlight the benefits of early and timely hemoperfusion the...
Source: Italian Journal of Pediatrics - April 22, 2024 Category: Pediatrics Source Type: research
Cancers, Vol. 16, Pages 1594: Endovascular Applications for the Management of High-Grade Gliomas in the Modern Era
Aziz-Sultan
Joshua D. Bernstock
High-grade gliomas (HGGs) have a poor prognosis and are difficult to treat. This review examines the evolving landscape of endovascular therapies for HGGs. Recent advances in endovascular catheter technology and delivery methods allow for super-selective intra-arterial cerebral infusion (SSIACI) with increasing precision. This treatment modality may offer the ability to deliver anti-tumoral therapies directly to tumor regions while minimizing systemic toxicity. However, challenges persist, including blood–brain barrier (BBB) penetration, hemodynamic complexities, and drug...
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Ari D. Kappel Rohan Jha Saibaba Guggilapu William J. Smith Abdullah H. Feroze Adam A. Dmytriw Juan Vicenty-Padilla Rodolfo E. Alcedo Guardia Florian A. Gessler Nirav J. Patel Rose Du Alfred P. See Pier Paolo Peruzzi Mohammad A. Aziz-Sultan Joshua D. Berns Tags: Review Source Type: research
Dysregulation of adipogenesis and disrupted lipid metabolism by the antidepressants citalopram and sertraline
Toxicol Appl Pharmacol. 2024 Apr 19:116937. doi: 10.1016/j.taap.2024.116937. Online ahead of print.ABSTRACTSelective Serotonin Reuptake Inhibitors (SSRIs) are widely used medications for the treatment of major depressive disorder. However, long-term SSRI use has been associated with weight gain and altered lipid profiles. These findings suggest that SSRIs may have negative effects on metabolism. Exposure to certain chemicals called 'obesogens' are known to promote lipid accumulation and obesity by modulating adipogenesis. Here, we investigated whether citalopram (CIT) and sertraline (SER) interfere with the process of adip...
Source: Toxicology and Applied Pharmacology - April 21, 2024 Category: Toxicology Authors: Deniz Bozdag Jeroen van Voorthuizen Nikita Korpel Sander Lentz Hande Gurer-Orhan Jorke H Kamstra Source Type: research
Protective effects of microbial biosurfactants produced by Bacillus halotolerans and Candida parapsilosis on bleomycin-induced pulmonary fibrosis in mice: Impact of antioxidant, anti-inflammatory and anti-fibrotic properties via TGF- β1/Smad-3 pathway and miRNA-326
Toxicol Appl Pharmacol. 2024 Apr 19:116939. doi: 10.1016/j.taap.2024.116939. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is an irreversible disease which considered the most fatal pulmonary fibrosis. Pulmonary toxicity including IPF is the most severe adverse effect of bleomycin, the chemotherapeutic agent. Based on the fact that, exogenous surfactants could induce alveolar stabilization in many lung diseases, the aim of this study was to explore the effects of low cost biosurfactants, surfactin (SUR) and sophorolipids (SLs), against bleomycin-induced pulmonary fibrosis in mice due to their antioxidan...
Source: Toxicology and Applied Pharmacology - April 21, 2024 Category: Toxicology Authors: Amria M Mousa Mohamed U Nooman Samah S Abbas Sahar M Gebril Mohamed Abdelraof Amr S Al-Kashef Source Type: research
Toxicogenomics of Five Cytostatics in Fathead Minnow (Pimephales promelas) Larvae
In this study, the toxicogenomic effects of five cytostatics (tamoxifen, methotrexate, capecitabine, cyclophosphamide, and ifosfamide) on fathead minnow (Pimephales promelas) larvae were evaluated. Post-fertilization eggs were exposed to increasing concentrations of the drugs for six days. The expression levels of two genetic biomarkers for toxicity and four thyroid hormone-related gene pathways were measured. Interestingly, the results showed that all concentrations of the five cytostatics affect the transcription levels of both toxicity biomarker genes. Additionally, the thyroid hormone-related genes had different expres...
Source: Bulletin of Environmental Contamination and Toxicology - April 21, 2024 Category: Environmental Health Authors: D C Casta ñeda-Cortés M Lefebvre-Raine G Triffault-Bouchet V S Langlois Source Type: research
Balancing robustness and adaptation rate for proton therapy of lung cancer patients
CONCLUSION: The lowered risk of post treatment toxicities at lower robustness levels is clinically relevant but comes at the expense of more treatment adaptations, particularly in cases where meeting our clinical goals is not compromised by having a dose that is more conformal to the target. The trade-off between workload and reduced NTCP needs to be individually assessed.PMID:38643807 | DOI:10.1016/j.radonc.2024.110290 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 21, 2024 Category: Radiology Authors: Vlad Badiu Vicki Trier Taasti Gilles Defraene Wouter van Elmpt Edmond Sterpin Source Type: research
Toxic anterior segment syndrome induced by cotton fiber after ICL implantation: A case report
Asian J Surg. 2024 Apr 20:S1015-9584(24)00722-X. doi: 10.1016/j.asjsur.2024.04.062. Online ahead of print.NO ABSTRACTPMID:38644112 | DOI:10.1016/j.asjsur.2024.04.062 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 21, 2024 Category: Surgery Authors: Xiangmei Kong Xiaohong Xiang Zhaoxia Huang Hongbin Lv Source Type: research
