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A randomized phase II study to assess the effect of adjuvant immunotherapy using α-GalCer-pulsed dendritic cells in the patients with completely resected stage II–IIIA non-small cell lung cancer: study protocol for a randomized controlled trial
DiscussionIn order to determine the efficacy of α-GalCer-pulsed DC therapy, the present study compares patients with stage II–III NSCLC who underwent complete surgical resection followed by postoperative adjuvant therapy with cisplatin plus vinorelbine, to those who did not receive additional treatment (surgical resection plus postoperative ad juvant chemotherapy only).Trial registrationUMIN000010386 (R000012145). Registered on 1 April 2013.UMIN-CTR is officially recognized as a registration site which satisfies ICMJE criteria. (Source: Trials)
Source: Trials - September 15, 2017 Category: Research Source Type: clinical trials

Local Control, Quality of Life and Toxicities in Adults With Benign or Indolent Brain Tumors Undergoing Proton Radiation Therapy
Condition:   Brain Tumor Intervention:   Radiation: Proton Radiation Sponsor:   Massachusetts General Hospital Not yet recruiting - verified September 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 12, 2017 Category: Research Source Type: clinical trials

Treatment of Peritoneal Carcinomatosis With Pressurized IntraPeritoneal Aerosol Chemotherapy -
Conditions:   Peritoneum; Carcinomatosis;   Peritoneal Neoplasms;   Peritoneal Metastases;   Chemotherapy Effect;   Chemotherapeutic Toxicity;   Quality of Life;   Histologic Progression Intervention:   Drug: PIPAC Sponsor:   Michael Bau Mortensen Recruiting - verified September 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 2, 2017 Category: Research Source Type: clinical trials

A rectal cancer feasibility study with an embedded phase III trial design assessing magnetic resonance tumour regression grade (mrTRG) as a novel biomarker to stratify management by good and poor response to chemoradiotherapy (TRIGGER): study protocol for a randomised controlled trial
DiscussionThe TRIGGER trial aims to determine whether patients with locally advanced rectal cancer can be recruited and subsequently randomised into a control trial that offers MRI-directed patient management according to radiological response to CRT (mrTRG). The feasibility study will inform a phase III trial design investigating stratified treatment of good and poor responders according to 3-year disease-free survival, colostomy-free survival as well as an increase in cases managed without a major resection.Trial registrationClinicalTrials.gov, ID:NCT02704520. Registered on 5 February 2016. (Source: Trials)
Source: Trials - August 29, 2017 Category: Research Source Type: clinical trials

Efficacy and Safety of Xenogenic AD-MSCs With Moderate to Severe Psoriasis
Conditions:   Mesenchymal Stromal Cells;   Psoriasis;   Drug Effect;   Drug Toxicity Intervention:   Biological: adipose-derived multipotent mesenchymal stem cells Sponsor:   Guangdong Provincial Hospital of Traditional Chinese Medicine Recruiting - verified August 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 25, 2017 Category: Research Source Type: clinical trials

Transthoracic Echocardiography of Inferior Vena Cava Before Spinal Anesthesia Can Predict Hypotension
Conditions:   Spinal Anesthetic Toxicity;   Inferior Vena Cava Abnormality;   Intraoperative Complications Intervention:   Procedure: spinal anesthesia Sponsor:   National and Kapodistrian University of Athens Recruiting - verified August 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 25, 2017 Category: Research Source Type: clinical trials

Efficacy and Safety of Xenogenic AD-MSCs With Moderate to Severe Psoriasis
Conditions:   Mesenchymal Stromal Cells;   Psoriasis;   Drug Effect;   Drug Toxicity Intervention:   Biological: adipose-derived multipotent mesenchymal stem cells Sponsor:   Guangdong Provincial Hospital of Traditional Chinese Medicine Recruiting - verified August 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 25, 2017 Category: Research Source Type: clinical trials

Transthoracic Echocardiography of Inferior Vena Cava Before Spinal Anesthesia Can Predict Hypotension
Conditions:   Spinal Anesthetic Toxicity;   Inferior Vena Cava Abnormality;   Intraoperative Complications Intervention:   Procedure: spinal anesthesia Sponsor:   National and Kapodistrian University of Athens Recruiting - verified August 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 25, 2017 Category: Research Source Type: clinical trials

Efficacy and Safety of Xenogenic AD-MSCs With Moderate to Severe Psoriasis
Conditions:   Mesenchymal Stromal Cells;   Psoriasis;   Drug Effect;   Drug Toxicity Intervention:   Biological: adipose-derived multipotent mesenchymal stem cells Sponsor:   Guangdong Provincial Hospital of Traditional Chinese Medicine Recruiting - verified August 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 25, 2017 Category: Research Source Type: clinical trials

Transthoracic Echocardiography of Inferior Vena Cava Before Spinal Anesthesia Can Predict Hypotension
Conditions:   Spinal Anesthetic Toxicity;   Inferior Vena Cava Abnormality;   Intraoperative Complications Intervention:   Procedure: spinal anesthesia Sponsor:   National and Kapodistrian University of Athens Recruiting - verified August 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 25, 2017 Category: Research Source Type: clinical trials

Efficacy and Safety of Xenogenic AD-MSCs With Moderate to Severe Psoriasis
Conditions:   Mesenchymal Stromal Cells;   Psoriasis;   Drug Effect;   Drug Toxicity Intervention:   Biological: adipose-derived multipotent mesenchymal stem cells Sponsor:   Guangdong Provincial Hospital of Traditional Chinese Medicine Recruiting - verified August 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 25, 2017 Category: Research Source Type: clinical trials

Transthoracic Echocardiography of Inferior Vena Cava Before Spinal Anesthesia Can Predict Hypotension
Conditions:   Spinal Anesthetic Toxicity;   Inferior Vena Cava Abnormality;   Intraoperative Complications Intervention:   Procedure: spinal anesthesia Sponsor:   National and Kapodistrian University of Athens Recruiting - verified August 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 25, 2017 Category: Research Source Type: clinical trials

Efficacy and Safety of Xenogenic AD-MSCs With Moderate to Severe Psoriasis
Conditions:   Mesenchymal Stromal Cells;   Psoriasis;   Drug Effect;   Drug Toxicity Intervention:   Biological: adipose-derived multipotent mesenchymal stem cells Sponsor:   Guangdong Provincial Hospital of Traditional Chinese Medicine Recruiting - verified August 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 25, 2017 Category: Research Source Type: clinical trials

Transthoracic Echocardiography of Inferior Vena Cava Before Spinal Anesthesia Can Predict Hypotension
Conditions:   Spinal Anesthetic Toxicity;   Inferior Vena Cava Abnormality;   Intraoperative Complications Intervention:   Procedure: spinal anesthesia Sponsor:   National and Kapodistrian University of Athens Recruiting - verified August 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 25, 2017 Category: Research Source Type: clinical trials

Efficacy and Safety of Xenogenic AD-MSCs With Moderate to Severe Psoriasis
Conditions:   Mesenchymal Stromal Cells;   Psoriasis;   Drug Effect;   Drug Toxicity Intervention:   Biological: adipose-derived multipotent mesenchymal stem cells Sponsor:   Guangdong Provincial Hospital of Traditional Chinese Medicine Recruiting - verified August 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 25, 2017 Category: Research Source Type: clinical trials

Transthoracic Echocardiography of Inferior Vena Cava Before Spinal Anesthesia Can Predict Hypotension
Conditions:   Spinal Anesthetic Toxicity;   Inferior Vena Cava Abnormality;   Intraoperative Complications Intervention:   Procedure: spinal anesthesia Sponsor:   National and Kapodistrian University of Athens Recruiting - verified August 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 25, 2017 Category: Research Source Type: clinical trials

Efficacy and Safety of Xenogenic AD-MSCs With Moderate to Severe Psoriasis
Conditions:   Mesenchymal Stromal Cells;   Psoriasis;   Drug Effect;   Drug Toxicity Intervention:   Biological: adipose-derived multipotent mesenchymal stem cells Sponsor:   Guangdong Provincial Hospital of Traditional Chinese Medicine Recruiting - verified August 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 25, 2017 Category: Research Source Type: clinical trials

Transthoracic Echocardiography of Inferior Vena Cava Before Spinal Anesthesia Can Predict Hypotension
Conditions:   Spinal Anesthetic Toxicity;   Inferior Vena Cava Abnormality;   Intraoperative Complications Intervention:   Procedure: spinal anesthesia Sponsor:   National and Kapodistrian University of Athens Recruiting - verified August 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 25, 2017 Category: Research Source Type: clinical trials

Efficacy and Safety of Xenogenic AD-MSCs With Moderate to Severe Psoriasis
Conditions:   Mesenchymal Stromal Cells;   Psoriasis;   Drug Effect;   Drug Toxicity Intervention:   Biological: adipose-derived multipotent mesenchymal stem cells Sponsor:   Guangdong Provincial Hospital of Traditional Chinese Medicine Recruiting - verified August 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 25, 2017 Category: Research Source Type: clinical trials

Efficacy and Safety of Expanded Allogeneic AD-MSCs With Moderate to Severe Psoriasis
Conditions:   Mesenchymal Stromal Cells;   Psoriasis;   Drug Effect;   Drug Toxicity Intervention:   Biological: adipose-derived multipotent mesenchymal stem cells Sponsor:   Guangdong Provincial Hospital of Traditional Chinese Medicine Recruiting - verified September 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 25, 2017 Category: Research Source Type: clinical trials

Transthoracic Echocardiography of Inferior Vena Cava Before Spinal Anesthesia Can Predict Hypotension
Conditions:   Spinal Anesthetic Toxicity;   Inferior Vena Cava Abnormality;   Intraoperative Complications Intervention:   Procedure: spinal anesthesia Sponsor:   National and Kapodistrian University of Athens Recruiting - verified August 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 25, 2017 Category: Research Source Type: clinical trials

Efficacy and Safety of Expanded Allogeneic AD-MSCs With Moderate to Severe Psoriasis
Conditions:   Mesenchymal Stromal Cells;   Psoriasis;   Drug Effect;   Drug Toxicity Intervention:   Biological: adipose-derived multipotent mesenchymal stem cells Sponsor:   Guangdong Provincial Hospital of Traditional Chinese Medicine Recruiting - verified September 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 25, 2017 Category: Research Source Type: clinical trials

Transthoracic Echocardiography of Inferior Vena Cava Before Spinal Anesthesia Can Predict Hypotension
Conditions:   Spinal Anesthetic Toxicity;   Inferior Vena Cava Abnormality;   Intraoperative Complications Intervention:   Procedure: spinal anesthesia Sponsor:   National and Kapodistrian University of Athens Recruiting - verified August 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 25, 2017 Category: Research Source Type: clinical trials

Efficacy and Safety of Expanded Allogeneic AD-MSCs With Moderate to Severe Psoriasis
Conditions:   Mesenchymal Stromal Cells;   Psoriasis;   Drug Effect;   Drug Toxicity Intervention:   Biological: adipose-derived multipotent mesenchymal stem cells Sponsor:   Guangdong Provincial Hospital of Traditional Chinese Medicine Recruiting - verified September 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 25, 2017 Category: Research Source Type: clinical trials

Transthoracic Echocardiography of Inferior Vena Cava Before Spinal Anesthesia Can Predict Hypotension
Conditions:   Spinal Anesthetic Toxicity;   Inferior Vena Cava Abnormality;   Intraoperative Complications Intervention:   Procedure: spinal anesthesia Sponsor:   National and Kapodistrian University of Athens Recruiting - verified August 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 25, 2017 Category: Research Source Type: clinical trials

Assessment of ibrutinib plus rituximab in front-line CLL (FLAIR trial): study protocol for a phase III randomised controlled trial
DiscussionThe trial aims to provide evidence for the future first-line treatment of CLL patients by assessing whether IR is superior to FCR in terms of PFS, and whether toxicity rates are favourable.Trial registrationISRCTN01844152. Registered on 8 August 2014, EudraCT number2013-001944-76. Registered on 26 April 2013. (Source: Trials)
Source: Trials - August 22, 2017 Category: Research Source Type: clinical trials

Association of Genetic Polymorphisms With Capecitabine-based Chemotherapy Toxicities in Chinese Solid Tumor Patients
Conditions:   Solid Tumor;   Capecitabine;   Drug-Related Side Effects and Adverse Reactions;   Pharmacogenetics;   Pharmacokinetics Intervention:   Genetic: detection of genotype Sponsor:   Peking University First Hospital Recruiting - verified August 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 17, 2017 Category: Research Source Type: clinical trials

Study Evaluating Late Toxicity Following Intensity-Modulated Radiotherapy and Two Image-Guided Strategies With Corresponding Treatment Margins.
Condition:   Prostate Cancer Interventions:   Device: Calypso beacon implant;   Radiation: Radiotherapy IMRT Sponsor:   Institut du Cancer de Montpellier - Val d'Aurelle Recruiting - verified August 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 16, 2017 Category: Research Source Type: clinical trials