Toxic red mud could be turned into 'green' steel
In this episode:0:46 Turning a toxic by-product into ironRed mud is a toxic by-product of aluminium manufacture, and millions of tonnes of it is produced each year. The majority ends up in landfills, pumped into vast lakes or stored in dried mounds, posing a serious environmental risk. This week, researchers demonstrate how red mud can be reused to make iron, a vital component in the production of steel. As their method uses hydrogen plasma rather than fossil fuels, they suggest it could be a way to reduce the carbon emissions associated with the steelmaking industry.Research article: Jovičević-Klug et al.News and Views:...
Source: Nature Podcast - January 24, 2024 Category: Science Authors: Springer Nature Limited Source Type: podcasts
How to tame a toxic yet life-saving antifungal
In this episode:00:46 Modifying a fungal drug to make it less toxicAmphotericin B is a drug used to treat life-threatening fungal infections. But while it is effective against many fungal species, it is also extremely toxic to kidneys, meaning it is mostly used as a drug of last-resort. This week, a team has unpicked the mechanism behind the drug’s toxicity, allowing them to modify it and reduce side effects in human kidney cells. The researchers hope this new version of the drug could become a useful tool in fighting fungal diseases.Research article: Maji et al.09:00 Research HighlightsReconstructing woolly rhino DNA us...
Source: Nature Podcast - November 8, 2023 Category: Science Authors: Springer Nature Limited Source Type: podcasts
Atorvastatin to Reduce Risk of Anthracycline-Associated Cardiac Dysfunction
Anthracyclines are used to treat a variety of cancers, but treatment may be limited by cardiac toxicity. JAMA Executive Editor Gregory Curfman, MD, discusses a new clinical trial on the use of atorvastatin to prevent anthracycline-induced cardiac toxicity with authors Tomas Neilan, MD, MPH, and Marielle Scherrer-Crosbie, MD, PhD. Related Content: Atorvastatin for Anthracycline-Associated Cardiac Dysfunction (Source: JAMA Author Interviews)
Source: JAMA Author Interviews - August 8, 2023 Category: General Medicine Authors: JAMA Network Source Type: podcasts
Limiting Acetaminophen in Prescription Combination Opioid Products
In 2011, the US Food and Drug Administration (FDA) announced a mandate to limit acetaminophen (paracetamol) to 325 mg/tablet in combination acetaminophen and opioid medications, with manufacturer compliance required by early 2014. In this podcast, JAMA Deputy Editor Mary M. McDermott, MD, interviews Jayme E. Locke, MD, MPH, and Babak J. Orandi, MD, PhD, about their JAMA study describing results of the FDA announcement on subsequent rates of hospitalizations for acute liver failure due to toxicity from acetaminophen-containing opioid drugs. Related Content: Association of FDA Mandate Limiting Acetaminophen (Paracetamol) in ...
Source: JAMA Author Interviews - March 7, 2023 Category: General Medicine Authors: JAMA Network Source Type: podcasts
Retinas revived after donor's death open door to new science
00:57 Reviving retinas to understand eyesResearch efforts to learn more about diseases of the human eye have been hampered as these organs degrade rapidly after death, and animal eyes are quite different to those from humans. To address this, a team have developed a new method to revive retinas taken from donors shortly after their death. They hope this will provide tissue for new studies looking into the workings of the human eye and nervous system.Research article: Abbas et al.08:05 Research HighlightsA technique that simplifies chocolate making yields fragrant flavours, and 3D imaging reveals some of the largest-known N...
Source: Nature Podcast - May 11, 2022 Category: Science Authors: Springer Nature Limited Source Type: podcasts
JAMA Oncology : Treatment Deescalation With Radiotherapy vs Transoral Surgery for HPV-Associated Oropharyngeal Squamous Cell Carcinoma
Interview with David Anthony Palma, MD, PhD, and Anthony C. Nichols, MD, authors of Assessment of Toxic Effects and Survival in Treatment Deescalation With Radiotherapy vs Transoral Surgery for HPV-Associated Oropharyngeal Squamous Cell Carcinoma: The ORATOR2 Phase 2 Randomized Clinical Trial Hosted by Jack West, MD. (Source: JAMA Specialty Journals Author Interviews)
Source: JAMA Specialty Journals Author Interviews - April 28, 2022 Category: General Medicine Authors: The JAMA Network Source Type: podcasts
JAMA Oncology : Clinical Outcomes and Toxic Effects of Single-Agent ICI Treatment Among Geriatric Patients With Cancer
Interview with Abdul Rafeh Naqash, MD, and Caroline A. Nebhan, MD, PhD, authors of Clinical Outcomes and Toxic Effects of Single-Agent Immune Checkpoint Inhibitors Among Patients Aged 80 Years or Older With Cancer: A Multicenter International Cohort Study. Hosted by Jack West, MD. (Source: JAMA Specialty Journals Author Interviews)
Source: JAMA Specialty Journals Author Interviews - November 4, 2021 Category: General Medicine Authors: The JAMA Network Source Type: podcasts
TWiV 815: MIS-C with Moshe Arditi and Ivet Bahar
Moshe and Ivet join TWiV to discuss their finding that MIS-C is a consequence of a superantigen in the spike protein of SARS-CoV-2 that causes activation of a skewed population of T cell receptor bearing lymphocytes, leading to hyperinflammation. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit and Kathy Spindler Guests: Moshe Arditi and Ivet Behar Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MIS-C in US children (NEJM) Superantigen in spike and T cell skewing in MIS-C (PNAS) MIS-C mimics toxic shock syndrome (J Allergy Clin Immunol) Antibody agains...
Source: This Week in Virology - MP3 Edition - October 10, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
The billion years missing from Earth ’s history
A new theory to explain missing geological time, the end of leaded petrol, and the ancient humans of Arabia.In this episode: 00:29 Unpicking the Great UnconformityFor more than 150 years, geologists have been aware of ‘missing’ layers of rock from the Earth’s geological record. Up to one billion years appear to have been erased in what’s known as the Great Unconformity. Many theories to explain this have been proposed, and now a new one suggests that the Great Unconformity may have in fact been a series of smaller events.BBC Future: The strange race to track down a missing billion years05:23 The era of leaded ...
Source: Nature Podcast - September 8, 2021 Category: Science Authors: Springer Nature Limited Source Type: podcasts
The billion years missing from Earth ’s history
A new theory to explain missing geological time, the end of leaded petrol, and the ancient humans of Arabia.In this episode: 00:29 Unpicking the Great UnconformityFor more than 150 years, geologists have been aware of ‘missing’ layers of rock from the Earth’s geological record. Up to one billion years appear to have been erased in what’s known as the Great Unconformity. Many theories to explain this have been proposed, and now a new one suggests that the Great Unconformity may have in fact been a series of smaller events.BBC Future: The strange race to track down a missing billion years05:23 The era of leaded ...
Source: Nature Podcast - September 8, 2021 Category: Science Authors: Springer Nature Limited Source Type: podcasts
JAMA Dermatology : Long-term Physical and Psychological Outcomes of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
Interview with Robert Gil Micheletti, MD, author of Long-term Physical and Psychological Outcomes of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (Source: JAMA Specialty Journals Author Interviews)
Source: JAMA Specialty Journals Author Interviews - May 5, 2021 Category: General Medicine Authors: The JAMA Network Source Type: podcasts
Audio long-read: Rise of the robo-writers
In 2020, the artificial intelligence (AI) GPT-3 wowed the world with its ability to write fluent streams of text. Trained on billions of words from books, articles and websites, GPT-3 was the latest in a series of ‘large language model’ AIs that are used by companies around the world to improve search results, answer questions, or propose computer code.However, these large language model are not without their issues. Their training is based on the statistical relationships between the words and phrases, which can lead to them generating toxic or dangerous outputs.Preventing responses like these is a huge challenge for ...
Source: Nature Podcast - April 6, 2021 Category: Science Authors: Springer Nature Limited Source Type: podcasts
Audio long-read: Rise of the robo-writers
In 2020, the artificial intelligence (AI) GPT-3 wowed the world with its ability to write fluent streams of text. Trained on billions of words from books, articles and websites, GPT-3 was the latest in a series of ‘large language model’ AIs that are used by companies around the world to improve search results, answer questions, or propose computer code.However, these large language model are not without their issues. Their training is based on the statistical relationships between the words and phrases, which can lead to them generating toxic or dangerous outputs.Preventing responses like these is a huge challenge for ...
Source: Nature Podcast - April 6, 2021 Category: Science Authors: Springer Nature Limited Source Type: podcasts
JAMA Oncology : Chronic Toxic Effects Following Adjuvant Anti –PD-1 Therapy for High-Risk Resected Melanoma
Interview with Douglas B. Johnson, MD, author of Chronic Immune-Related Adverse Events Following Adjuvant Anti–PD-1 Therapy for High-risk Resected Melanoma (Source: JAMA Specialty Journals Author Interviews)
Source: JAMA Specialty Journals Author Interviews - March 25, 2021 Category: General Medicine Authors: The JAMA Network Source Type: podcasts
