Genome-based characterization of a novel prophage of Vibrio parahaemolyticus, VPS05ph1, a novel member of Peduoviridae
In this study, two prophages (VPS05ph1 and VPS05ph2) were identified in a V. parahaemolyticus isolate through genomic and transcriptional analyses. Both prophages were determined as HP1-like phages, located in a novel phylogenetic lineage of Peduoviridae. They shared a moderate genome-wide sequence similarity with each other and high synteny with the closest relatives, but showed low identities to the repressor counterparts of the representative phages within the family. In addition, no bacterial virulence genes, antibiotic resistance genes and known phage-encoded lytic proteins were identified on both prophage genomes. Mo...
Source: Virology - April 18, 2024 Category: Virology Authors: Hailiang Wang Guosi Xie Jie Huang Source Type: research
Assessment of the neutralizing antibody response in Omicron breakthrough cases in healthcare workers who received the homologous booster of Moderna mRNA-1273
Virology. 2024 Apr 8;595:110082. doi: 10.1016/j.virol.2024.110082. Online ahead of print.ABSTRACTVaccines against SARS-CoV-2 were developed during the pandemic including the BNT162b2 and the mRNA-1273. We evaluated the levels of binding antibodies against the receptor binding domain and the levels of NAbs in individuals who developed a breakthrough infection after having received three doses of mRNA-1273. A total of 51 participants were included. The breakthrough group was compared to a 1:1 matched-control group. Among the 51 individuals, 18 (35%) developed a breakthrough infection. The GMT of NAbs against the BA.1 in the ...
Source: Virology - April 18, 2024 Category: Virology Authors: Constant Gillot Marie Tr é-Hadry Roberto Cupaiolo Laurent Blairon Alain Wilmet Ingrid Beukinga Jean-Michel Dogn é Jonathan Douxfils Julien Favresse Source Type: research
AMPK restricts HHV-6A replication by inhibiting glycolysis and mTOR signaling
In this study, we investigated the role of AMPK in response to human herpesvirus 6A (HHV-6A) infection. We show that HHV-6A infection significantly downregulates the active phosphorylated state of AMPK in infected T cells. Pharmacological activation of AMPK highly attenuated HHV-6A propagation. Mechanistically, we found that the activation of AMPK by AICAR blocked HHV-6-induced glycolysis by inhibiting glucose metabolism and lactate secretion, as well as decreasing expressions of key glucose transporters and glycolytic enzymes. In addition, mTOR signaling has been inactivated in HHV-6A infected T cells by AICAR treatment. ...
Source: Virology - April 17, 2024 Category: Virology Authors: Xiaodi Yang Siyu Tian Zhujiang Min Emanuela Garbarino Jingjing Ma Junli Jia Huamin Tang Lingyun Li Source Type: research
Opportunistic sampling of yellow canary (Crithagra flaviventris) has revealed a high genetic diversity of detected parvoviral sequences
Virology. 2024 Apr 4;595:110081. doi: 10.1016/j.virol.2024.110081. Online ahead of print.ABSTRACTParvoviruses are known to be significant viral pathogens that infect a wide range of species globally. However, little is known about the parvoviruses circulating in Australian birds, including yellow canaries. Here, we present four parvoviral sequences including three novel parvoviruses detected from 10 yellow canaries (Crithagra flaviventris), named canary chaphamaparvovirus 1 and -2 (CaChPV1 and CaChPV2), canary dependoparvovirus 1 and -2 (CaDePV1 and CaDePV2). The whole genome sequences of CaChPV1, CaChPV2, CaDePV1, and CaD...
Source: Virology - April 10, 2024 Category: Virology Authors: Yuhao Zhang Saranika Talukder Md Safiul Alam Bhuiyan Lei He Subir Sarker Source Type: research
Porcine respiratory coronavirus genome sequences; comparisons and relationships to transmissible gastroenteritis viruses
In this study we obtained and compared PRCV sequences from Europe and the US, and investigated how these are related to transmissible gastroenteritis virus (TGEV) sequences. The whole genome sequences of Danish (1/90-DK), Italian (PRCV15087/12 III NPTV Parma), and Belgian PRCV (91V44) strains are presented. These sequences were aligned with nine other PRCV sequences from Europe and the US, and 43 TGEV sequences. Following alignment of the PRCV sequences, it was apparent that multiple amino acid variations in the structural proteins were distinct between the European and US strains. The alignments were used to build phyloge...
Source: Virology - April 10, 2024 Category: Virology Authors: Amalie Ehlers Bedsted Thomas Bruun Rasmussen Laura D Martinenghi Anette B øtner Hans Nauwynck Graham J Belsham Source Type: research
Opportunistic sampling of yellow canary (Crithagra flaviventris) has revealed a high genetic diversity of detected parvoviral sequences
Virology. 2024 Apr 4;595:110081. doi: 10.1016/j.virol.2024.110081. Online ahead of print.ABSTRACTParvoviruses are known to be significant viral pathogens that infect a wide range of species globally. However, little is known about the parvoviruses circulating in Australian birds, including yellow canaries. Here, we present four parvoviral sequences including three novel parvoviruses detected from 10 yellow canaries (Crithagra flaviventris), named canary chaphamaparvovirus 1 and -2 (CaChPV1 and CaChPV2), canary dependoparvovirus 1 and -2 (CaDePV1 and CaDePV2). The whole genome sequences of CaChPV1, CaChPV2, CaDePV1, and CaD...
Source: Virology - April 10, 2024 Category: Virology Authors: Yuhao Zhang Saranika Talukder Md Safiul Alam Bhuiyan Lei He Subir Sarker Source Type: research
Porcine respiratory coronavirus genome sequences; comparisons and relationships to transmissible gastroenteritis viruses
In this study we obtained and compared PRCV sequences from Europe and the US, and investigated how these are related to transmissible gastroenteritis virus (TGEV) sequences. The whole genome sequences of Danish (1/90-DK), Italian (PRCV15087/12 III NPTV Parma), and Belgian PRCV (91V44) strains are presented. These sequences were aligned with nine other PRCV sequences from Europe and the US, and 43 TGEV sequences. Following alignment of the PRCV sequences, it was apparent that multiple amino acid variations in the structural proteins were distinct between the European and US strains. The alignments were used to build phyloge...
Source: Virology - April 10, 2024 Category: Virology Authors: Amalie Ehlers Bedsted Thomas Bruun Rasmussen Laura D Martinenghi Anette B øtner Hans Nauwynck Graham J Belsham Source Type: research
Opportunistic sampling of yellow canary (Crithagra flaviventris) has revealed a high genetic diversity of detected parvoviral sequences
Virology. 2024 Apr 4;595:110081. doi: 10.1016/j.virol.2024.110081. Online ahead of print.ABSTRACTParvoviruses are known to be significant viral pathogens that infect a wide range of species globally. However, little is known about the parvoviruses circulating in Australian birds, including yellow canaries. Here, we present four parvoviral sequences including three novel parvoviruses detected from 10 yellow canaries (Crithagra flaviventris), named canary chaphamaparvovirus 1 and -2 (CaChPV1 and CaChPV2), canary dependoparvovirus 1 and -2 (CaDePV1 and CaDePV2). The whole genome sequences of CaChPV1, CaChPV2, CaDePV1, and CaD...
Source: Virology - April 10, 2024 Category: Virology Authors: Yuhao Zhang Saranika Talukder Md Safiul Alam Bhuiyan Lei He Subir Sarker Source Type: research
Porcine respiratory coronavirus genome sequences; comparisons and relationships to transmissible gastroenteritis viruses
In this study we obtained and compared PRCV sequences from Europe and the US, and investigated how these are related to transmissible gastroenteritis virus (TGEV) sequences. The whole genome sequences of Danish (1/90-DK), Italian (PRCV15087/12 III NPTV Parma), and Belgian PRCV (91V44) strains are presented. These sequences were aligned with nine other PRCV sequences from Europe and the US, and 43 TGEV sequences. Following alignment of the PRCV sequences, it was apparent that multiple amino acid variations in the structural proteins were distinct between the European and US strains. The alignments were used to build phyloge...
Source: Virology - April 10, 2024 Category: Virology Authors: Amalie Ehlers Bedsted Thomas Bruun Rasmussen Laura D Martinenghi Anette B øtner Hans Nauwynck Graham J Belsham Source Type: research
Opportunistic sampling of yellow canary (Crithagra flaviventris) has revealed a high genetic diversity of detected parvoviral sequences
Virology. 2024 Apr 4;595:110081. doi: 10.1016/j.virol.2024.110081. Online ahead of print.ABSTRACTParvoviruses are known to be significant viral pathogens that infect a wide range of species globally. However, little is known about the parvoviruses circulating in Australian birds, including yellow canaries. Here, we present four parvoviral sequences including three novel parvoviruses detected from 10 yellow canaries (Crithagra flaviventris), named canary chaphamaparvovirus 1 and -2 (CaChPV1 and CaChPV2), canary dependoparvovirus 1 and -2 (CaDePV1 and CaDePV2). The whole genome sequences of CaChPV1, CaChPV2, CaDePV1, and CaD...
Source: Virology - April 10, 2024 Category: Virology Authors: Yuhao Zhang Saranika Talukder Md Safiul Alam Bhuiyan Lei He Subir Sarker Source Type: research
Porcine respiratory coronavirus genome sequences; comparisons and relationships to transmissible gastroenteritis viruses
In this study we obtained and compared PRCV sequences from Europe and the US, and investigated how these are related to transmissible gastroenteritis virus (TGEV) sequences. The whole genome sequences of Danish (1/90-DK), Italian (PRCV15087/12 III NPTV Parma), and Belgian PRCV (91V44) strains are presented. These sequences were aligned with nine other PRCV sequences from Europe and the US, and 43 TGEV sequences. Following alignment of the PRCV sequences, it was apparent that multiple amino acid variations in the structural proteins were distinct between the European and US strains. The alignments were used to build phyloge...
Source: Virology - April 10, 2024 Category: Virology Authors: Amalie Ehlers Bedsted Thomas Bruun Rasmussen Laura D Martinenghi Anette B øtner Hans Nauwynck Graham J Belsham Source Type: research
Opportunistic sampling of yellow canary (Crithagra flaviventris) has revealed a high genetic diversity of detected parvoviral sequences
Virology. 2024 Apr 4;595:110081. doi: 10.1016/j.virol.2024.110081. Online ahead of print.ABSTRACTParvoviruses are known to be significant viral pathogens that infect a wide range of species globally. However, little is known about the parvoviruses circulating in Australian birds, including yellow canaries. Here, we present four parvoviral sequences including three novel parvoviruses detected from 10 yellow canaries (Crithagra flaviventris), named canary chaphamaparvovirus 1 and -2 (CaChPV1 and CaChPV2), canary dependoparvovirus 1 and -2 (CaDePV1 and CaDePV2). The whole genome sequences of CaChPV1, CaChPV2, CaDePV1, and CaD...
Source: Virology - April 10, 2024 Category: Virology Authors: Yuhao Zhang Saranika Talukder Md Safiul Alam Bhuiyan Lei He Subir Sarker Source Type: research
Porcine respiratory coronavirus genome sequences; comparisons and relationships to transmissible gastroenteritis viruses
In this study we obtained and compared PRCV sequences from Europe and the US, and investigated how these are related to transmissible gastroenteritis virus (TGEV) sequences. The whole genome sequences of Danish (1/90-DK), Italian (PRCV15087/12 III NPTV Parma), and Belgian PRCV (91V44) strains are presented. These sequences were aligned with nine other PRCV sequences from Europe and the US, and 43 TGEV sequences. Following alignment of the PRCV sequences, it was apparent that multiple amino acid variations in the structural proteins were distinct between the European and US strains. The alignments were used to build phyloge...
Source: Virology - April 10, 2024 Category: Virology Authors: Amalie Ehlers Bedsted Thomas Bruun Rasmussen Laura D Martinenghi Anette B øtner Hans Nauwynck Graham J Belsham Source Type: research
Opportunistic sampling of yellow canary (Crithagra flaviventris) has revealed a high genetic diversity of detected parvoviral sequences
Virology. 2024 Apr 4;595:110081. doi: 10.1016/j.virol.2024.110081. Online ahead of print.ABSTRACTParvoviruses are known to be significant viral pathogens that infect a wide range of species globally. However, little is known about the parvoviruses circulating in Australian birds, including yellow canaries. Here, we present four parvoviral sequences including three novel parvoviruses detected from 10 yellow canaries (Crithagra flaviventris), named canary chaphamaparvovirus 1 and -2 (CaChPV1 and CaChPV2), canary dependoparvovirus 1 and -2 (CaDePV1 and CaDePV2). The whole genome sequences of CaChPV1, CaChPV2, CaDePV1, and CaD...
Source: Virology - April 10, 2024 Category: Virology Authors: Yuhao Zhang Saranika Talukder Md Safiul Alam Bhuiyan Lei He Subir Sarker Source Type: research
Porcine respiratory coronavirus genome sequences; comparisons and relationships to transmissible gastroenteritis viruses
In this study we obtained and compared PRCV sequences from Europe and the US, and investigated how these are related to transmissible gastroenteritis virus (TGEV) sequences. The whole genome sequences of Danish (1/90-DK), Italian (PRCV15087/12 III NPTV Parma), and Belgian PRCV (91V44) strains are presented. These sequences were aligned with nine other PRCV sequences from Europe and the US, and 43 TGEV sequences. Following alignment of the PRCV sequences, it was apparent that multiple amino acid variations in the structural proteins were distinct between the European and US strains. The alignments were used to build phyloge...
Source: Virology - April 10, 2024 Category: Virology Authors: Amalie Ehlers Bedsted Thomas Bruun Rasmussen Laura D Martinenghi Anette B øtner Hans Nauwynck Graham J Belsham Source Type: research
