The pharmacological management of asthma in adults: 2023 update
Expert Opin Pharmacother. 2024 Mar 18. doi: 10.1080/14656566.2024.2332627. Online ahead of print.ABSTRACTINTRODUCTION: The pharmacotherapy of asthma is a dynamic process that changes as our knowledge of the underlying pathophysiology and treatment of this disease continues to evolve. This implies the need for continuous revision of the recommendations of asthma guidelines and strategies.AREAS COVERED: This review summarizes the latest key practical information on the pharmacological management of asthma in adults. We provide the background to the 2023 update of the GINA strategy report, focusing on changes and discussing a...
Source: Expert Opinion on Pharmacotherapy - March 18, 2024 Category: Drugs & Pharmacology Authors: Maria Gabriella Matera Barbara Rinaldi Rosa Annibale Vito De Novellis Mario Cazzola Source Type: research

An evaluation of Rezafungin: the latest treatment option for adults with candidemia and invasive candidiasis
Expert Opin Pharmacother. 2024 Mar 18. doi: 10.1080/14656566.2024.2331775. Online ahead of print.ABSTRACTINTRODUCTION: Invasive fungal infections, especially candidemia and invasive candidiasis, continue to cause substantial morbidity and mortality. In addition, the emergence of drug-resistant Candida species, notably C. glabrata and C. auris, along with limitations in available treatments, highlights the urgent need for novel, effective antifungal agents.AREAS COVERED: This review discusses the results of in vitro studies evaluating the spectrum and highlights the pharmacokinetic/pharmacodynamic properties. It also includ...
Source: Expert Opinion on Pharmacotherapy - March 18, 2024 Category: Drugs & Pharmacology Authors: Divisha Sharma Jose A Vazquez Source Type: research

Pharmacotherapeutic advances for chronic myelogenous leukemia: beyond tyrosine kinase inhibitors
In conclusion, novel therapeutic perspectives are emerging for CML, holding the potential for substantial advancements in disease treatment.PMID:38488824 | DOI:10.1080/14656566.2024.2331778 (Source: Expert Opinion on Pharmacotherapy)
Source: Expert Opinion on Pharmacotherapy - March 15, 2024 Category: Drugs & Pharmacology Authors: Alessandro Costa Emilia Scalzulli Ida Carmosino Claudia Ielo Maria Laura Bisegna Maurizio Martelli Massimo Breccia Source Type: research

Novel pharmacotherapeutic options for the treatment of postural orthostatic tachycardia syndrome
Expert Opin Pharmacother. 2024 Mar 11:1-8. doi: 10.1080/14656566.2024.2319224. Online ahead of print.ABSTRACTINTRODUCTION: Postural tachycardia syndrome (POTS) is a disorder characterized by a constellation of symptoms including lightheadedness, fatigue, and palpitations when upright, associated with an increase in the heart rate (HR) of > 30 beats per minute when changing from a lying down to standing position or head-up tilt position and not associated with orthostatic hypotension. The causes as well as the management of POTS are not quite fully understood.AREAS COVERED: We performed a literature review on the diagnos...
Source: Expert Opinion on Pharmacotherapy - March 11, 2024 Category: Drugs & Pharmacology Authors: Anthony Lyonga Ngonge Christabel Nyange Jalal K Ghali Source Type: research

Therapeutic strategies in Fc γIIA receptor-dependent thrombosis and thromboinflammation as seen in heparin-induced thrombocytopenia (HIT) and vaccine-induced immune thrombocytopenia and thrombosis (VITT)
Expert Opin Pharmacother. 2024 Mar 12:1-14. doi: 10.1080/14656566.2024.2328241. Online ahead of print.ABSTRACTINTRODUCTION: Fcγ-receptors (FcγR) are membrane receptors expressed on a variety of immune cells, specialized in recognition of the Fc part of immunoglobulin G (IgG) antibodies. FcγRIIA-dependent platelet activation in platelet factor 4 (PF4) antibody-related disorders have gained major attention, when these antibodies were identified as the cause of the adverse vaccination event termed vaccine-induced immune thrombocytopenia and thrombosis (VITT) during the COVID-19 vaccination campaign. With the recognition of...
Source: Expert Opinion on Pharmacotherapy - March 11, 2024 Category: Drugs & Pharmacology Authors: Luisa M üller Venkata A S Dabbiru Linda Sch önborn Andreas Greinacher Source Type: research

Long-acting second-generation injectable antipsychotics for the maintenance treatment of bipolar disorder: a narrative review
Expert Opin Pharmacother. 2024 Mar 11:1-5. doi: 10.1080/14656566.2024.2329743. Online ahead of print.ABSTRACTINTRODUCTION: Non-adherence to medication significantly affects bipolar disorder outcomes. Long-Acting Injectable antipsychotics show promise by ensuring adherence and averting relapses.AREAS COVERED: This narrative review sought to evaluate the efficacy of second-generation injectable antipsychotics in bipolar disorder through searches in Embase, MEDLINE, and PsycInfo for randomized controlled trials and mirror-image studies.Risperidone and aripiprazole Long-Acting Injectables demonstrated effectiveness in preventi...
Source: Expert Opinion on Pharmacotherapy - March 11, 2024 Category: Drugs & Pharmacology Authors: Jean-Baptiste Belge Bernard G C C Sabbe Source Type: research

Novel pharmacotherapeutic options for the treatment of postural orthostatic tachycardia syndrome
Expert Opin Pharmacother. 2024 Mar 11:1-8. doi: 10.1080/14656566.2024.2319224. Online ahead of print.ABSTRACTINTRODUCTION: Postural tachycardia syndrome (POTS) is a disorder characterized by a constellation of symptoms including lightheadedness, fatigue, and palpitations when upright, associated with an increase in the heart rate (HR) of > 30 beats per minute when changing from a lying down to standing position or head-up tilt position and not associated with orthostatic hypotension. The causes as well as the management of POTS are not quite fully understood.AREAS COVERED: We performed a literature review on the diagnos...
Source: Expert Opinion on Pharmacotherapy - March 11, 2024 Category: Drugs & Pharmacology Authors: Anthony Lyonga Ngonge Christabel Nyange Jalal K Ghali Source Type: research

Therapeutic strategies in Fc γIIA receptor-dependent thrombosis and thromboinflammation as seen in heparin-induced thrombocytopenia (HIT) and vaccine-induced immune thrombocytopenia and thrombosis (VITT)
Expert Opin Pharmacother. 2024 Mar 12:1-14. doi: 10.1080/14656566.2024.2328241. Online ahead of print.ABSTRACTINTRODUCTION: Fcγ-receptors (FcγR) are membrane receptors expressed on a variety of immune cells, specialized in recognition of the Fc part of immunoglobulin G (IgG) antibodies. FcγRIIA-dependent platelet activation in platelet factor 4 (PF4) antibody-related disorders have gained major attention, when these antibodies were identified as the cause of the adverse vaccination event termed vaccine-induced immune thrombocytopenia and thrombosis (VITT) during the COVID-19 vaccination campaign. With the recognition of...
Source: Expert Opinion on Pharmacotherapy - March 11, 2024 Category: Drugs & Pharmacology Authors: Luisa M üller Venkata A S Dabbiru Linda Sch önborn Andreas Greinacher Source Type: research

Long-acting second-generation injectable antipsychotics for the maintenance treatment of bipolar disorder: a narrative review
Expert Opin Pharmacother. 2024 Mar 11:1-5. doi: 10.1080/14656566.2024.2329743. Online ahead of print.ABSTRACTINTRODUCTION: Non-adherence to medication significantly affects bipolar disorder outcomes. Long-Acting Injectable antipsychotics show promise by ensuring adherence and averting relapses.AREAS COVERED: This narrative review sought to evaluate the efficacy of second-generation injectable antipsychotics in bipolar disorder through searches in Embase, MEDLINE, and PsycInfo for randomized controlled trials and mirror-image studies.Risperidone and aripiprazole Long-Acting Injectables demonstrated effectiveness in preventi...
Source: Expert Opinion on Pharmacotherapy - March 11, 2024 Category: Drugs & Pharmacology Authors: Jean-Baptiste Belge Bernard G C C Sabbe Source Type: research

Novel pharmacotherapeutic options for the treatment of postural orthostatic tachycardia syndrome
Expert Opin Pharmacother. 2024 Mar 11:1-8. doi: 10.1080/14656566.2024.2319224. Online ahead of print.ABSTRACTINTRODUCTION: Postural tachycardia syndrome (POTS) is a disorder characterized by a constellation of symptoms including lightheadedness, fatigue, and palpitations when upright, associated with an increase in the heart rate (HR) of > 30 beats per minute when changing from a lying down to standing position or head-up tilt position and not associated with orthostatic hypotension. The causes as well as the management of POTS are not quite fully understood.AREAS COVERED: We performed a literature review on the diagnos...
Source: Expert Opinion on Pharmacotherapy - March 11, 2024 Category: Drugs & Pharmacology Authors: Anthony Lyonga Ngonge Christabel Nyange Jalal K Ghali Source Type: research

Therapeutic strategies in Fc γIIA receptor-dependent thrombosis and thromboinflammation as seen in heparin-induced thrombocytopenia (HIT) and vaccine-induced immune thrombocytopenia and thrombosis (VITT)
Expert Opin Pharmacother. 2024 Mar 11. doi: 10.1080/14656566.2024.2328241. Online ahead of print.ABSTRACTINTRODUCTION: Fcγ-receptors (FcγR) are membrane receptors expressed on a variety of immune cells, specialized in recognition of the Fc part of immunoglobulin G (IgG) antibodies. FcγRIIA-dependent platelet activation in platelet factor 4 (PF4) antibody related disorders have gained major attention, when these antibodies were identified as the cause of the adverse vaccination event termed vaccine-induced immune thrombocytopenia and thrombosis (VITT) during the Covid-19 vaccination campaign. With the recognition of anti...
Source: Expert Opinion on Pharmacotherapy - March 11, 2024 Category: Drugs & Pharmacology Authors: Luisa M üller Venkata A S Dabbiru Linda Sch önborn Andreas Greinacher Source Type: research

Long-acting second-generation injectable antipsychotics for the maintenance treatment of bipolar disorder: a narrative review
Expert Opin Pharmacother. 2024 Mar 11:1-5. doi: 10.1080/14656566.2024.2329743. Online ahead of print.ABSTRACTINTRODUCTION: Non-adherence to medication significantly affects bipolar disorder outcomes. Long-Acting Injectable antipsychotics show promise by ensuring adherence and averting relapses.AREAS COVERED: This narrative review sought to evaluate the efficacy of second-generation injectable antipsychotics in bipolar disorder through searches in Embase, MEDLINE, and PsycInfo for randomized controlled trials and mirror-image studies.Risperidone and aripiprazole Long-Acting Injectables demonstrated effectiveness in preventi...
Source: Expert Opinion on Pharmacotherapy - March 11, 2024 Category: Drugs & Pharmacology Authors: Jean-Baptiste Belge Bernard G C C Sabbe Source Type: research

Novel pharmacotherapeutic options for the treatment of postural orthostatic tachycardia syndrome
Expert Opin Pharmacother. 2024 Mar 11:1-8. doi: 10.1080/14656566.2024.2319224. Online ahead of print.ABSTRACTINTRODUCTION: Postural tachycardia syndrome (POTS) is a disorder characterized by a constellation of symptoms including lightheadedness, fatigue, and palpitations when upright, associated with an increase in the heart rate (HR) of > 30 beats per minute when changing from a lying down to standing position or head-up tilt position and not associated with orthostatic hypotension. The causes as well as the management of POTS are not quite fully understood.AREAS COVERED: We performed a literature review on the diagnos...
Source: Expert Opinion on Pharmacotherapy - March 11, 2024 Category: Drugs & Pharmacology Authors: Anthony Lyonga Ngonge Christabel Nyange Jalal K Ghali Source Type: research