Synthesis of LAVR-289, a new [(Z)-3-(acetoxymethyl)-4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl]phosphonic acid prodrug with pronounced antiviral activity against DNA viruses
Eur J Med Chem. 2024 Apr 15;271:116412. doi: 10.1016/j.ejmech.2024.116412. Online ahead of print.ABSTRACTNew acyclic pyrimidine nucleoside phosphonate prodrugs with a 4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl]phosphonic acid skeleton (O-DAPy nucleobase) were prepared through a convergent synthesis by olefin cross-metathesis as the key step. Several acyclic nucleoside 4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl]phosphonic acid prodrug exhibited in vitro antiviral activity in submicromolar or nanomolar range against varicella zoster virus (VZV), human cytomegalovirus (HCMV), human herpes virus type 1 (HSV-1) and type 2 (HS...
Source: Herpes - April 21, 2024 Category: Infectious Diseases Authors: Maximes Bessi ères Vincent Roy Tuniyazi Abuduani Patrick Favetta Robert Snoeck Graciela Andrei Jennifer Moffat Franck Gallardo Luigi A Agrofoglio Source Type: research
Green synthesis of silver nanoparticles based on using Croton urucurana and their toxicity against freshwater snail species Biomphalaria glabrata
Acta Trop. 2024 Apr 19:107224. doi: 10.1016/j.actatropica.2024.107224. Online ahead of print.ABSTRACTGreen plant-based silver nanoparticles (GP-Ag NPs) have contributed to the development of ecological technologies with low environmental impact and safer for human health, as well as demonstrating potential for the control of vectors and intermediate hosts. However, knowledge about its toxicity in the early stages of gastropod development remains scarce. Therefore, the current study aimed to investigate the toxicity of GP-Ag NPs synthesized from Croton urucurana leaf extracts in snail species Biomphalaria glabrata, which is...
Source: Acta Tropica - April 21, 2024 Category: Infectious Diseases Authors: Paula Sampaio Ara újo Maxwell Batista Caixeta Eloiza da Silva Nunes Bruno Bastos Gon çalves Thiago Lopes Rocha Source Type: research
Discovery of a Novel Lidocaine Metabolite by Human Liver Microsome and Identification of Microbial Species Which Produces the Same Metabolite
In this study, we identified an unknown metabolite of the anaesthetic drug lidocaine, which is metabolised by HLM. By screening for lidocaine metabolic activity in five types of foods (blue cheese, shiitake mushroom, natto, yoghurt, and dry yeast), we found that bacteria isolated from natto reproduced the lidocaine metabolic reaction that occurs in HLM. A fraction containing the unknown lidocaine metabolite was prepared through mass cultivation of a Bacillus subtilis standard strain, ethyl acetate extraction, open column chromatography, and HPLC purification. We identified the unknown metabolite as 3-(2,6-dimethylphenyl)-1...
Source: Chemical and Pharmaceutical Bulletin - April 21, 2024 Category: Drugs & Pharmacology Authors: Sho Hori Hikari Taniguchi Sota Yoshimura Kanako Takeda Ryusei Yamashita Atsushi Kimishima Kazuo Harada Source Type: research
The differential impact of iron on ferroptosis, oxidative stress, and inflammatory reaction in head-kidney macrophages of yellow catfish (Pelteobagrus fulvidraco) with and without ammonia stress
This study aimed to investigate the effect of iron on indicators of fish exposed to ammonia, specifically on the three aspects mentioned above. The head kidney macrophages of yellow catfish were randomly assigned to one of four groups: CON (normal control), AM (0.046 mg L-1 total ammonia nitrogen), Fe (20 μg mL-1 FeSO4), and Fe+AM (20 μg mL-1 FeSO4, 0.046 mg L-1 total ammonia nitrogen). The cells were pretreated with FeSO4 for 6 hours followed by ammonia for 24 hours. The study found that iron supplementation led to an excessive accumulation of iron and ROS in macrophages, but it did not strongly induce ferroptosis, oxid...
Source: Developmental and Comparative Immunology - April 21, 2024 Category: Allergy & Immunology Authors: Kewei He Xinran Long Haibo Jiang Chuanjie Qin Source Type: research
Genotoxic and antiproliferative properties of Endopleura uchi bark aqueous extract
(Source: Journal of Toxicology and Environmental Health Part A)
Source: Journal of Toxicology and Environmental Health Part A - April 21, 2024 Category: Environmental Health Authors: de Lima e Souza Mesquita Da Cruz Corr êa de Barros Falc ão Ferraz Miri Farias Reginatto Boaretto dos Santos da Silva Grivicich Picada Source Type: research
Mitophagy and its regulatory mechanisms in the biological effects of nanomaterials
AbstractMitophagy is a selective cellular process critical for the removal of damaged mitochondria. It is essential in regulating mitochondrial number, ensuring mitochondrial functionality, and maintaining cellular equilibrium, ultimately influencing cell destiny. Numerous pathologies, such as neurodegenerative diseases, cardiovascular disorders, cancers, and various other conditions, are associated with mitochondrial dysfunctions. Thus, a detailed exploration of the regulatory mechanisms of mitophagy is pivotal for enhancing our understanding and for the discovery of novel preventive and therapeutic options for these dise...
Source: Journal of Applied Toxicology - April 21, 2024 Category: Toxicology Authors: Rui Zhang,
Haitao Yang,
Menghao Guo,
Shuyan Niu,
Yuying Xue Tags: REVIEW ARTICLE Source Type: research
Contemporary Role of Radiation Therapy in Testicular Cancer
Testicular cancer is a rare but curable male malignancy. Seminoma represents the majority of germ cell tumors and is considered radiation sensitive. Radiation treatment plays a role in adjuvant therapy after orchiectomy of stage I, IIA, and IIB seminomas. Radiation dose de-escalation has been effective in preventing tumor recurrences while also limiting acute and long-term toxicities. However, long-term risks, including the prevailing concern of secondary malignancy risk, between adjuvant radiation and chemotherapy play a role in recommendations. Ongoing work continues to be performed to reduce radiation field and dose in ...
Source: Urologic Clinics of North America - April 21, 2024 Category: Urology & Nephrology Authors: Jay C. Shiao, Xinglei Shen Source Type: research
Cobrotoxin, a single peptide from snake venom, ameliorates atopic dermatitis via suppression of MK2 modulated by IgE and IL-33
ConclusionThe study suggests that CoTX has anti-allergic and anti-inflammatory effects in allergic AD. By targeting IL-33 and IgE pathways, CoTX demonstrated potential in regulating mast cell activation and inflammatory cytokine production. The observed improvements in the AD mouse model indicate CoTX as a promising candidate for further research towards developing effective and safe treatments for AD. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 21, 2024 Category: Cytology Source Type: research
Syagrus coronata fixed oil prevents rotenone-induced movement disorders and oxidative stress in Drosophila melanogas
(Source: Journal of Toxicology and Environmental Health Part A)
Source: Journal of Toxicology and Environmental Health Part A - April 21, 2024 Category: Environmental Health Authors: dos Santos Nunes de Amorim Bezerra da Silva dos Santos Gubert de Menezesa Duarte Barros da Silveira Andrade-da-Costa dos Santos dos Santos Correia da Rosa Source Type: research
Deciphering styrene oxide tolerance mechanisms in Gluconobacter oxydans mutant strain
This study provides new insights into the mechanisms underlying the toxicological response to OS stress and offers potential targets for enhancing the solvent tolerance of G. oxydans.PMID:38642663 | DOI:10.1016/j.biortech.2024.130674 (Source: Bioresource Technology)
Source: Bioresource Technology - April 20, 2024 Category: Biotechnology Authors: Yan Chen Fei Liu Aobo Sha Meijuan Xu Zhiming Rao Xian Zhang Source Type: research
Thermoelectric performance of hybrid inorganic/organic composites based on PEDOT:PSS/tin(II) oxide
Chemphyschem. 2024 Apr 20:e202300877. doi: 10.1002/cphc.202300877. Online ahead of print.ABSTRACTPSS(poly(3,4-ethylenedioxylthiophene):poly(styrenesulfonate))-based composites often exhibit remarkable characteristics regarding high electrical conductivity and great processability, being a suitable candidate for thermoelectric (TE) applications. To increase its performance, PEDOT:PSS is commonly blended with scarce and toxic inorganic compounds based on Se, Te or Bi. In this work we propose the use of one p-type metal oxide semiconductor (MOs): tin(II) oxide (SnO), motivated by its abundance and low toxicity. Hybrid PEDOT:P...
Source: Chemphyschem - April 20, 2024 Category: Chemistry Authors: Antonio V ázquez-López David Maestre Ana Cremades Source Type: research
Green synthesis of Superparamagnetic Iron Oxide and Silver Nanoparticles in Satureja hortensis Leave Extract: Evaluation of Antifungal Effects on Botryosphaeriaceae Species
Curr Microbiol. 2024 Apr 20;81(6):149. doi: 10.1007/s00284-024-03647-3.ABSTRACTIn recent years, green synthesis methods of metallic nanoparticles (MNPs) have been attractive because of the more facile, cheaper, and appropriate features associated with biomolecules in MNPs biosynthesis. This research represented an easy, fast, and environmentally friendly method to biosynthesis of superparamagnetic iron oxide nanoparticles (SPIONPs) and silver nanoparticles (AgNPs) by the Satureja hortensis leaf extract as stabilizer and reducer. The SPIONPs synthesized in co-precipitation method. The biosynthesized SPIONPs and AgNPs were s...
Source: Current Microbiology - April 20, 2024 Category: Microbiology Authors: Sara Abedini Shahram Pourseyedi Jafar Zolala Hamid Mohammadi Roohollah Abdolshahi Source Type: research
Caspase-3/Gasdermin E-mediated pyroptosis contributes to Ricin toxin-induced inflammation
Toxicol Lett. 2024 Apr 18;396:19-27. doi: 10.1016/j.toxlet.2024.04.007. Online ahead of print.ABSTRACTRicin toxin (RT) is highly cytotoxic and can release a considerable amount of pro-inflammatory factors due to depurination, causing excessive inflammation that may aggravate the harm to the body. Pyroptosis, a type of gasdermin-mediated cell death, is a contributor to the exacerbation of inflammation. Accumulating evidence indicate that pyroptosis plays a significant role in the pathogen infection and tissue injury, suggesting a potential correlation between pyroptosis and RT-induced inflammation. Here, we aim to demonstra...
Source: Toxicology Letters - April 20, 2024 Category: Toxicology Authors: Yuxin Xu Mingxin Dong Chengbiao Sun Yan Wang Na Zhao Kaikai Yu Nan Lu Na Xu Wensen Liu Congmei Wu Source Type: research
What are the global patterns of microplastic ingestion by fish? a scientometric review
Environ Pollut. 2024 Apr 18:123972. doi: 10.1016/j.envpol.2024.123972. Online ahead of print.ABSTRACTThe billions of tons of plastic released into the environment mostly fragment into smaller particles that reach rivers and oceans, posing toxicity risks to aquatic organisms. As fish serve as excellent environmental indicator organisms, this study aims to comprehensively review and quantify published data regarding the abundance of microplastics (MPs) ingested by fish through scientometric analysis. Systematic analysis reveals that global aquatic ecosystems are contaminated by MPs, with the characteristics of these contamin...
Source: Environmental Pollution - April 20, 2024 Category: Environmental Health Authors: Vania Aparecida Sacco Natana Raquel Zuanazzi Amanda Selinger Jo ão Henrique Alliprandini da Costa Érika Spanhol Lemunie Camila Luiza Comelli Vin ícius Abilhoa Fernando Carlos de Sousa Luis Fernando F ávaro Lorena M Rios Mendoza N édia de Castilhos Gh Source Type: research
Presence of humic acid in the environment holds promise as a potential mitigating factor for the joint toxicity of polystyrene nanoplastics and herbicide atrazine to Chlorella vulgaris: 96-h acute toxicity
This study firstly highlights the role of HA in mitigating the toxicity of PS-NH2 when combined with other harmful compounds, enhancing our understanding of HA's presence in the environment.PMID:38642775 | DOI:10.1016/j.chemosphere.2024.142061 (Source: Chemosphere)
Source: Chemosphere - April 20, 2024 Category: Chemistry Authors: Mehdi Khoshnamvand Dongmei You Yafang Xie Yixiao Feng Marriya Sultan Xingyi Wei Jingli Li Ailing Fu De-Sheng Pei Source Type: research
