Triclocarban induces lipid droplet accumulation and oxidative stress responses by inhibiting mitochondrial fatty acid oxidation in HepaRG cells
Toxicol Lett. 2024 Apr 15:S0378-4274(24)00067-5. doi: 10.1016/j.toxlet.2024.04.002. Online ahead of print.ABSTRACTMitochondrial fatty acid oxidation (mtFAO) plays an important role in hepatic energy metabolism. Severe mtFAO injury leads to nonalcoholic fatty liver disease (NAFLD) and liver failure. Several drugs have been withdrawn owing to safety issues, such as induction of fatty liver disease through mtFAO disruption. For instance, the antimicrobial triclocarban (TCC), an environmental contaminant that was removed from the market due to its unknown safety in humans, induces NAFLD in rats and promotes hepatic FAO in mice...
Source: Toxicology Letters - April 17, 2024 Category: Toxicology Authors: Hitoshi Nakamura Toshikatsu Matsui Tadahiro Shinozawa Source Type: research
Stevioside mitigates lead toxicity in thinlip mullet juveniles: Impacts on growth, metabolism, and immune function
In conclusion, stevioside, especially at 450 mg, positively impacted growth, biochemical parameters, antioxidant activity, immune response, and gene expression in L. ramada exposed to lead, suggesting its potential to mitigate lead toxicity in aquaculture. Additional research is warranted to investigate the long-term impacts of stevioside supplementation and its prospective implementation in aquaculture.PMID:38631122 | DOI:10.1016/j.aquatox.2024.106910 (Source: Aquatic Toxicology)
Source: Aquatic Toxicology - April 17, 2024 Category: Toxicology Authors: Akram Ismael Shehata Shimaa A Shahin Ayaat M Elmaghraby Mayada Alhoshy Mohamed M Toutou Ali A Soliman Asem A Amer Yusuf Jibril Habib Mahmoud S Gewaily Islam I Teiba Mohammed F El Basuini Source Type: research
Di-n-butyl phthalate induces toxicity in male fetal mouse testicular development by regulating the MAPK signaling pathway
In conclusion, our study provides the first evidence that the MAPK signaling pathway is involved in DBP-induced reproductive toxicity and highlights the importance of JNK1 as a potential target of DBP in inducing reproductive toxicity.PMID:38631520 | DOI:10.1016/j.taap.2024.116933 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - April 17, 2024 Category: Toxicology Authors: Xinwei Wan Xudong Cui Xiang Wang Mingyang Feng Shinan Wei Jia Yu Sha Cheng Heng Luo Jianxin Hu Source Type: research
Evaluation of aconitine cardiotoxicity with a heart-on-a-particle prepared by a microfluidic device
Chem Commun (Camb). 2024 Apr 17. doi: 10.1039/d4cc00396a. Online ahead of print.ABSTRACTA heart-on-a-particle model based on multicompartmental microgel is proposed to simulate the heart microenvironment and study the cardiotoxicity of drugs. The relevant microgel was fabricated by a biocompatible microfluidic-based approach, where heart function-related HL-1 and HUVEC cells were arranged in separate compartments. Finally, the mechanism of aconitine-induced heart toxicity was elucidated using mass spectrometry and molecular biotechnology.PMID:38629248 | DOI:10.1039/d4cc00396a (Source: Chemical Communications)
Source: Chemical Communications - April 17, 2024 Category: Chemistry Authors: Tong Xu Zengnan Wu Hongren Yao Yingrui Zhang Shiyu Chen Yuxuan Li Xian-Li Meng Yi Zhang Jin-Ming Lin Source Type: research
Effectiveness of statins in people living with HIV: a systematic review and meta-analysis of randomized controlled trials
CONCLUSION: When considered collectively, statin therapy's advantages appear to exceed its occasional predictable side effects like liver or muscle toxicity.REGISTRATION: PROSPERO registration ID: CRD42023469521.PMID:38629133 | DOI:10.1080/17512433.2024.2344672 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - April 17, 2024 Category: Drugs & Pharmacology Authors: Sai Santhosha Mrudula Alla Dhruv J Shah Vysakh Ratheesh Deekshitha Alla Thanmayee Tummala Moksh S Khetan Ritika J Shah Ruth G Bayeh Mahek Fatima Sanah K Ahmed Mert Sab ıroğlu Source Type: research
Treatment adherence and adverse event management in chronic lymphocytic leukemia: challenges and strategies for the future
We describe how such a program can be designed and implemented.PMID:38629382 | DOI:10.1080/17512433.2024.2344665 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - April 17, 2024 Category: Drugs & Pharmacology Authors: Maurlia D Upchurch Benyam Muluneh Source Type: research
Hesperidin activates Nrf2 to protect cochlear hair cells from cisplatin-induced damage
This study employs both in vivo and in vitro models of cisplatin ototoxicity to explore this possibility. Our results reveal that hesperidin mitigates cisplatin-induced ototoxicity by activating the Nrf2/NQO1 pathway in sensory hair cells, thereby reducing ROS accumulation, preventing hair cell apoptosis, and alleviating hearing loss.PMID:38629504 | DOI:10.1080/13510002.2024.2341470 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - April 17, 2024 Category: Biochemistry Authors: Jintao Lou Fan Wu Wuhui He Rui Hu Ziyi Cai Guisheng Chen Wenji Zhao Zhigang Zhang Yu Si Source Type: research
MSC-derived exosomes mitigate cadmium-induced male reproductive injury by ameliorating DNA damage and autophagic flux
This study aims to investigate the protective effects of MSC-Exos against cadmium toxicity on male reproduction. Our findings reveal that MSC-Exos treatment significantly promotes spermatogenesis, improves sperm quality, and reduces germ cell apoptosis in cadmium-exposed mice. Mechanistically, MSC-Exos dramatically mitigate cadmium-induced cell apoptosis in a spermatogonia cell line (GC-1 spg) in vitro by reducing DNA damage and promoting autophagic flux. These results suggest that MSC-Exos have a protective effect on cadmium-induced germ cell apoptosis by ameliorating DNA damage and autophagy flux, demonstrating the thera...
Source: Ecotoxicology and Environmental Safety - April 17, 2024 Category: Environmental Health Authors: Zhihong Chen Jiahui Mo Qiyun Yang Zexin Guo Xinyu Li Dongmei Xie Chunhua Deng Source Type: research
Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells
In this study, we investigated the effects of CBD and its metabolites on TM3 mouse Leydig cells. CBD, at concentrations below 30 µM, reduced cell viability, induced G1 cell cycle arrest, and inhibited DNA synthesis. CBD induced apoptosis after exposure to high concentrations (≥ 50 µM) for 24 h or a low concentration (20 µM) for 6 days. 7-Hydroxy-CBD and 7-carboxy-CBD, the main CBD metabolites of CBD, exhibited the similar toxic effects as CBD. In addition, we conducted a time-course mRNA-sequencing analysis in both primary human Leydig cells and TM3 mouse Leydig cells to understand and compare the mechanisms underlyin...
Source: Archives of Toxicology - April 17, 2024 Category: Toxicology Authors: Yuxi Li Qiangen Wu Xilin Li Patrick Cournoyer Supratim Choudhuri Lei Guo Si Chen Source Type: research
Characterizing the toxicological responses to inorganic arsenicals and their metabolites in immortalized human bladder epithelial cells
Arch Toxicol. 2024 Apr 17. doi: 10.1007/s00204-024-03750-1. Online ahead of print.ABSTRACTArsenic is highly toxic to the human bladder. In the present study, we established a human bladder epithelial cell line that closely mimics normal human bladder epithelial cells by immortalizing primary uroplakin 1B-positive human bladder epithelial cells with human telomerase reverse transcriptase (HBladEC-T). The uroplakin 1B-positive human bladder epithelial cell line was then used to evaluate the toxicity of seven arsenicals (iAsV, iAsIII, MMAV, MMAIII, DMAV, DMAIII, and DMMTAV). The cellular uptake and metabolism of each arsenica...
Source: Archives of Toxicology - April 17, 2024 Category: Toxicology Authors: Arpamas Vachiraarunwong Min Gi Tohru Kiyono Shugo Suzuki Masaki Fujioka Guiyu Qiu Runjie Guo Tomoki Yamamoto Anna Kakehashi Masayuki Shiota Hideki Wanibuchi Source Type: research
Assessment of human dermal absorption of flame retardant additives in polyethylene and polypropylene microplastics using 3D human skin equivalent models
Environ Int. 2024 Apr 5;186:108635. doi: 10.1016/j.envint.2024.108635. Online ahead of print.ABSTRACTTo overcome ethical and technical challenges impeding the study of human dermal uptake of chemical additives present in microplastics (MPs), we employed 3D human skin equivalent (3D-HSE) models to provide first insights into the dermal bioavailability of polybrominated diphenyl ether (PBDEs) present in MPs; and evaluated different factors influencing human percutaneous absorption of PBDEs under real-life exposure scenario. PBDEs were bioavailable to varying degrees (up to 8 % of the exposure dose) and percutaneous permeatio...
Source: Environment International - April 17, 2024 Category: Environmental Health Authors: Ovokeroye Akpojevwe Abafe Stuart Harrad Mohamed Abou-Elwafa Abdallah Source Type: research
The effects of a glyphosate-based herbicide on the bovine gametes during an in vitro embryo production model
Environ Pollut. 2024 Apr 15:123967. doi: 10.1016/j.envpol.2024.123967. Online ahead of print.ABSTRACTRoundup® (R), while it is the most used herbicide globally, and its residues are ubiquitous in urban and suburban areas, its impact on vertebrates' safety remains highly debated. Here, in three in vitro experiments, we investigated the effects of a very low dose (1 ppm) of R on the fertilization capacity and embryo development in cattle. In the first experiment, frozen-thawed bull semen exposed to R for 1 h exhibited reduced motility parameters but unaffected fertilization ability. However, after in vitro fertilization, th...
Source: Environmental Pollution - April 17, 2024 Category: Environmental Health Authors: E Dovolou I Nanas T Giannoulis A Fytsilli A Ntemka G Anifandis I Tsakmakidis G S Amiridis Source Type: research
Evaluating efficacy of Pseudomonas sp. EN-4 to lower the toxic potential of 4-bromophenol and assessing its competency in simulated microcosm
Environ Pollut. 2024 Apr 15:123990. doi: 10.1016/j.envpol.2024.123990. Online ahead of print.ABSTRACTAn indigenous bacterium Pseudomonas sp. EN-4 had been reported earlier for its ability to co-metabolise 4-bromophenol (4-BP), in presence of phenol (100 mg/L) as co-substrate. The present study was undertaken to validate the efficacy of biotransformation by comparing the toxicity profiles of untreated and EN-4 transformed samples of 4-BP, using both plant and animal model. The toxicity studies in Allium cepa (A. cepa) indicated to lowering of mitotic index (MI) from 12.77% (water) to 3.33% in A. cepa bulbs exposed to 4-BP+p...
Source: Environmental Pollution - April 17, 2024 Category: Environmental Health Authors: Rohit Mahajan Geetika Sharma Pooja Chadha Harvinder Singh Saini Source Type: research
Recoverable and degradable carboxymethyl chitosan polyelectrolyte hydrogel film for ultra stable encapsulation of curcumin
Int J Biol Macromol. 2024 Apr 15:131616. doi: 10.1016/j.ijbiomac.2024.131616. Online ahead of print.ABSTRACTHydrogels have shown great potential for application in food science due to their diverse functionalities. However, most hydrogels inevitably contain toxic chemical cross-linking agent residues, posing serious food safety concerns. In this paper, a curcumin/sodium alginate/carboxymethyl chitosan hydrogels (CSCH) were prepared by self-assembly of two oppositely charged polysaccharides, carboxymethyl chitosan and sodium alginate, to form a three-dimensional network encapsulating curcumin for extending food shelf life. ...
Source: International Journal of Biological Macromolecules - April 17, 2024 Category: Biochemistry Authors: Yuwei Zhang Dengshuang Guo Xi Shen Zhongfeng Tang Baofeng Lin Source Type: research
Synthesis and characterization of novel guar gum based waste material derived nanocomposite for effective removal of hexabromocyclododecane and lindane
Int J Biol Macromol. 2024 Apr 15:131535. doi: 10.1016/j.ijbiomac.2024.131535. Online ahead of print.ABSTRACTHerein, efficient degradation of hexabromocyclododecane (HBCD) and Lindane, a persistent organic pollutant using guar gum based calcium oxide doped silicon dioxide (GG-CaO@SiO2) has been reported. The nanocomposite was prepared by waste egg shell (CaO) and rice husk (SiO2) was well characterized. The maximum degradation of HBCD and Lindane were observed at 8 mg catalyst loading, basic pH, and 2 mg L-1 of pollutant amount. The photocatalytic performance of GG-CaO@SiO2 for HBCD and Lindane photodegradation was evaluate...
Source: International Journal of Biological Macromolecules - April 17, 2024 Category: Biochemistry Authors: None Keshu Manviri Rani Uma Shanker Source Type: research
