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Specialization of the auditory system for the processing of bio-sonar information in the frequency domain: Mustached bats.
Abstract For echolocation, mustached bats emit velocity-sensitive orientation sounds (pulses) containing a constant-frequency component consisting of four harmonics (CF1-4). They show unique behavior called Doppler-shift compensation for Doppler-shifted echoes and hunting behavior for frequency and amplitude modulated echoes from fluttering insects. Their peripheral auditory system is highly specialized for fine frequency analysis of CF2 (∼61.0 kHz) and detecting echo CF2 from fluttering insects. In their central auditory system, lateral inhibition occurring at multiple levels sharpens V-shaped frequency-tun...
Source: Hearing Research - February 2, 2018 Category: Audiology Authors: Suga N Tags: Hear Res Source Type: research

Suppression of the vestibular short-latency evoked potential by electrical stimulation of the central vestibular system.
Abstract In an attempt to view the effects of the efferent vestibular system (EVS) on peripheral dynamic vestibular function, we have monitored the Vestibular short-latency Evoked Potential (VsEP) evoked by pulses of bone conducted vibration during electrical stimulation of the EVS neurons near the floor of the fourth ventricle in the brainstem of anesthetized guinea pigs. Given the reported effects of EVS on primary afferent activity, we hypothesized that EVS stimulation would cause a slight reduction in the VsEP amplitude. Our results show a substantial (>50%) suppression of the VsEP, occurring immediately af...
Source: Hearing Research - February 2, 2018 Category: Audiology Authors: Pastras CJ, Curthoys IS, Sokolic L, Brown DJ Tags: Hear Res Source Type: research

Low- and high-frequency cortical brain oscillations reflect dissociable mechanisms of concurrent speech segregation in noise.
Abstract Parsing simultaneous speech requires listeners use pitch-guided segregation which can be affected by the signal-to-noise ratio (SNR) in the auditory scene. The interaction of these two cues may occur at multiple levels within the cortex. The aims of the current study were to assess the correspondence between oscillatory brain rhythms and determine how listeners exploit pitch and SNR cues to successfully segregate concurrent speech. We recorded electrical brain activity while participants heard double-vowel stimuli whose fundamental frequencies (F0s) differed by zero or four semitones (STs) presented in ei...
Source: Hearing Research - February 2, 2018 Category: Audiology Authors: Yellamsetty A, Bidelman GM Tags: Hear Res Source Type: research

The relation between flocculus volume and tinnitus after cerebellopontine angle tumor surgery.
CONCLUSIONS: The lack of a relation between flocculus volumes and the presence of tinnitus, combined with the significant correlation between tinnitus severity and flocculus volumes, suggests that the flocculus may not be the primary source of tinnitus, but is likely to mediate tinnitus severity. The reduced ipsi-to-contralateral volume ratio in patients with gaze-modulated tinnitus suggests that atrophy of the flocculus on the surgery side triggers cross-modal interactions leading to modulation of tinnitus. PMID: 29398141 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - January 31, 2018 Category: Audiology Authors: Mennink LM, Van Dijk JMC, Van Der Laan BFAM, Metzemaekers JDM, Van Laar PJ, Van Dijk P Tags: Hear Res Source Type: research

Unilateral congenital hearing loss in children: Challenges and potentials.
Abstract The estimated incidence of sensorineural hearing impairment (>40 dB HL) at birth is 1.86 per 1000 newborns in developed countries and 30-40% of these are unilateral. Profound sensorineural unilateral hearing impairment or single sided deafness (SSD) can be treated with a cochlear implant. However, this treatment is costly and invasive and unnecessary in the eyes of many. Very young children with SSD often do not exhibit language and cognitive delays and it is hard to imagine that neurocognitive skills will present difficulties with one good ear. In the current paper we review the most recent evidence...
Source: Hearing Research - January 30, 2018 Category: Audiology Authors: van Wieringen A, Boudewyns A, Sangen A, Wouters J, Desloovere C Tags: Hear Res Source Type: research

Subcortical pathways: Towards a better understanding of auditory disorders.
rs CV Abstract Hearing loss is a significant problem that affects at least 15% of the population. This percentage, however, is likely significantly higher because of a variety of auditory disorders that are not identifiable through traditional tests of peripheral hearing ability. In these disorders, individuals have difficulty understanding speech, particularly in noisy environments, even though the sounds are loud enough to hear. The underlying mechanisms leading to such deficits are not well understood. To enable the development of suitable treatments to alleviate or prevent such disorders, the affected processi...
Source: Hearing Research - January 26, 2018 Category: Audiology Authors: Felix RA, Gourévitch B, Portfors CV Tags: Hear Res Source Type: research

Transcriptomic analysis of chicken cochleae after gentamicin damage and the involvement of four signaling pathways (Notch, FGF, Wnt and BMP) in hair cell regeneration.
Abstract Unlike mammalian hair cells, which are essentially unable to regenerate after damage, avian hair cells have a robust capacity for regeneration. The prerequisite for understanding the above difference is knowing the genetic programming of avian hair cell regeneration. Although the major processes have been known, the precise molecular signaling that induces regeneration remains unclear. To address this issue, we performed a high-throughput transcriptomic analysis of gene expression during hair cell regeneration in the chick cochlea after antibiotic injury in vivo. A total of 16,588 genes were found to...
Source: Hearing Research - January 17, 2018 Category: Audiology Authors: Jiang L, Xu J, Jin R, Bai H, Zhang M, Yang S, Zhang X, Zhang X, Han Z, Zeng S Tags: Hear Res Source Type: research

Evidence of noise-induced subclinical hearing loss using auditory brainstem responses and objective measures of noise exposure in humans.
Abstract Exposure to loud sound places the auditory system at considerable risk, especially when the exposure is routine. The current study examined the impact of routine auditory overexposure in young human adults with clinically-normal audiometric thresholds by measuring the auditory brainstem response (ABR), an electrophysiological measure of peripheral and central auditory processing. Sound exposure was measured objectively with body-worn noise dosimeters over a week. Participants were divided into low-exposure and high-exposure groups, with the low-exposure group having an average daily noise exposure dose of...
Source: Hearing Research - January 11, 2018 Category: Audiology Authors: Skoe E, Tufts J Tags: Hear Res Source Type: research

Induction of mitophagy in the HEI-OC1 auditory cell line and activation of the Atg12/LC3 pathway in the organ of Corti.
Abstract Autophagy is a highly evolutionary conserved quality control defense mechanism within cells, which has also been implicated in cell death processes. In the mammalian inner ear, autophagy has been shown to play a role during early morphogenesis as well as in adult cochlear hair cells exposed to ototoxic insults. Mitophagy, a selective autophagic cell process targeting mitochondria, hasn't been studied in the inner ear so far. On this work, we searched for molecular indicators of mitophagy within House Ear Institute-Organ of Corti-1 (HEI-OC1) cells as well as in the organ of Corti (OC). We first tested for ...
Source: Hearing Research - January 11, 2018 Category: Audiology Authors: Setz C, Benischke AS, Pinho Ferreira Bento AC, Brand Y, Levano S, Paech F, Leitmeyer K, Bodmer D Tags: Hear Res Source Type: research

Neural representation of octave illusion in the human cortex revealed with functional magnetic resonance imaging.
This study aimed to explore the link between the perception of illusory pitches and brain activity during presentation of dichotic tones. We conducted a behavioral study of how participants perceived binaural dichotic tones of octave illusions and classified them, based on the reported percepts, in an illusion (ILL) group, without an illusion (non-ILL) group, and others. We recorded brain activity using functional magnetic resonance imaging and analyzed the activation due to dichotic illusion tones. The activation in the bilateral planum polare in the auditory cortex was significantly larger in the ILL group than in the no...
Source: Hearing Research - January 8, 2018 Category: Audiology Authors: Tanaka K, Kurasaki H, Kuriki S Tags: Hear Res Source Type: research

Incorporating behavioral and sensory context into spectro-temporal models of auditory encoding.
Abstract For several decades, auditory neuroscientists have used spectro-temporal encoding models to understand how neurons in the auditory system represent sound. Derived from early applications of systems identification tools to the auditory periphery, the spectro-temporal receptive field (STRF) and more sophisticated variants have emerged as an efficient means of characterizing representation throughout the auditory system. Most of these encoding models describe neurons as static sensory filters. However, auditory neural coding is not static. Sensory context, reflecting the acoustic environment, and behavioral ...
Source: Hearing Research - December 31, 2017 Category: Audiology Authors: David SV Tags: Hear Res Source Type: research

A biophysical modelling platform of the cochlear nucleus and other auditory circuits: From channels to networks.
Abstract Models of the auditory brainstem have been an invaluable tool for testing hypotheses about auditory information processing and for highlighting the most important gaps in the experimental literature. Due to the complexity of the auditory brainstem, and indeed most brain circuits, the dynamic behavior of the system may be difficult to predict without a detailed, biologically realistic computational model. Despite the sensitivity of models to their exact construction and parameters, most prior models of the cochlear nucleus have incorporated only a small subset of the known biological properties. This confo...
Source: Hearing Research - December 28, 2017 Category: Audiology Authors: Manis PB, Campagnola L Tags: Hear Res Source Type: research

Auditory sensory gating predicts acceptable noise level.
PMID: 29325873 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - December 28, 2017 Category: Audiology Authors: Miller SE, Wathen K, Cash E, Pitts T, Cornell L Tags: Hear Res Source Type: research

Perceptual changes with monopolar and phantom electrode stimulation.
This study investigates the perceptual differences (including pitch and other sound quality differences) at multiple electrode positions using MP and PE stimulation using both a multidimensional scaling procedure (MDS) and a traditional scaling procedure. 10 Advanced Bionics users reported the perceptual distances between 5 single electrode (typically 1, 3, 5, 7, and 9) stimuli in either MP or PE (σ = 0.5) mode. Subjects were asked to report how perceptually different each pair of stimuli were using any perceived differences except loudness. Subsequently, each stimulus was presented in isolation and subjects scal...
Source: Hearing Research - December 28, 2017 Category: Audiology Authors: Klawitter S, Landsberger DM, Büchner A, Nogueira W Tags: Hear Res Source Type: research

What can stimulus polarity and interphase gap tell us about auditory nerve function in cochlear-implant recipients?
Abstract Modeling studies suggest that differences in neural responses between polarities might reflect underlying neural health. Specifically, large differences in electrically evoked compound action potential (eCAP) amplitudes and amplitude-growth-function (AGF) slopes between polarities might reflect poorer peripheral neural health, whereas more similar eCAP responses between polarities might reflect better neural health. The interphase gap (IPG) has also been shown to relate to neural survival in animal studies. Specifically, healthy neurons exhibit larger eCAP amplitudes, lower thresholds, and steeper AGF slo...
Source: Hearing Research - December 28, 2017 Category: Audiology Authors: Hughes ML, Choi S, Glickman E Tags: Hear Res Source Type: research

Transauricular vagus nerve stimulation at auricular acupoints Kindey (CO10), Yidan (CO11), Liver (CO12) and Shenmen (TF4) can induce auditory and limbic cortices activation measured by fMRI.
In conclusion, taVNS at acupoints CO10-12, TF4 could activate the prefrontal, auditory and limbic cortices of healthy brain and this scheme could be a promising tool for tinnitus treatment. PMID: 29305037 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - December 24, 2017 Category: Audiology Authors: Peng L, Mu K, Liu A, Zhou L, Gao Y, Shenoy IT, Mei Z, Chen Q Tags: Hear Res Source Type: research

Intentional switching in auditory selective attention: Exploring attention shifts with different reverberation times.
Abstract Using a well-established binaural-listening paradigm the ability to intentionally switch auditory selective attention was examined under anechoic, low reverberation (0.8 s) and high reverberation (1.75 s) conditions. Twenty-three young, normal-hearing subjects were tested in a within-subject design to analyze influences of the reverberation times. Spoken word pairs by two speakers were presented simultaneously to subjects from two of eight azimuth positions. The stimuli consisted of a single number word, (i.e., 1 to 9), followed by either the direction "UP" or "DOWN" in German. Gui...
Source: Hearing Research - December 22, 2017 Category: Audiology Authors: Oberem J, Seibold J, Koch I, Fels J Tags: Hear Res Source Type: research

Negative-delay sources in distortion product otoacoustic emissions.
Abstract Long-delay components showing a symmetrical pattern with positive and negative delays can be observed in the time-frequency representation (or in the inverse Fourier transform) of distortion product otoacoustic emissions. Positive-only phase-gradient delays are predicted by place-fixed backscattering mechanisms, such as coherent reflection due to roughness, whereas the nonlinear distortion wave-fixed mechanism should generate an almost null-delay component. The symmetrical delay pattern arises whenever spectral amplitude fluctuations are not fully correlated to phase fluctuations. An interpretation of thi...
Source: Hearing Research - December 22, 2017 Category: Audiology Authors: Sisto R, Shera CA, Moleti A Tags: Hear Res Source Type: research

Communication pathways to and from the inner ear and their contributions to drug delivery.
Abstract The environment of the inner ear is highly regulated in a manner that some solutes are permitted to enter while others are excluded or transported out. Drug therapies targeting the sensory and supporting cells of the auditory and vestibular systems require the agent to gain entry to the fluid spaces of the inner ear, perilymph or endolymph, which surround the sensory organs. Access to the inner ear fluids from the vasculature is limited by the blood-labyrinth barriers, which include the blood-perilymph and blood-strial barriers. Intratympanic applications provide an alternative approach in which drugs are...
Source: Hearing Research - December 19, 2017 Category: Audiology Authors: Salt AN, Hirose K Tags: Hear Res Source Type: research

Non-tip auditory-nerve responses that are suppressed by low-frequency bias tones originate from reticular lamina motion.
Abstract Recent cochlear mechanical measurements show that active processes increase the motion response of the reticular lamina (RL) at frequencies more than an octave below the local characteristic frequency (CF) for CFs above 5 kHz. A possible correlate is that in high-CF (>5 kHz) auditory-nerve (AN) fibers, responses to frequencies 1-3 octaves below CF ("tail" frequencies) can be inhibited by medial olivocochlear (MOC) efferents. These results indicate that active processes enhance the sensitivity of tail-frequency RL and AN responses. Perhaps related is that some apical low-CF AN fibers have ...
Source: Hearing Research - December 14, 2017 Category: Audiology Authors: Nam H, Guinan JJ Tags: Hear Res Source Type: research

Electrically-evoked auditory steady-state responses as neural correlates of loudness growth in cochlear implant users.
This study investigated whether electrically-evoked auditory steady-state response amplitude growth functions correspond to behaviorally measured loudness growth functions. Seven cochlear implant listeners participated in two behavioral loudness growth tasks and an EEG recording session. The 40-Hz sinusoidally amplitude-modulated pulse trains were presented to CI channels stimulating at a more apical and basal region of the cochlea, and were presented at different current levels encompassing the listeners' dynamic ranges. Behaviorally, loudness growth was measured using an Absolute Magnitude Estimation and a Graphic Rating...
Source: Hearing Research - December 8, 2017 Category: Audiology Authors: Van Eeckhoutte M, Wouters J, Francart T Tags: Hear Res Source Type: research

Self reported hearing difficulty, tinnitus, and normal audiometric thresholds, the National Health and Nutrition Examination Survey 1999-2002.
Abstract Perceived hearing difficulty (HD) and/or tinnitus in the presence of normal audiometric thresholds present a clinical challenge. Yet, there is limited data regarding prevalence and determinant factors contributing to HD. Here we present estimates generalized to the non-institutionalized population of the United States based on the cross-sectional population-based study, the National Health and Nutrition and Examination Survey (NHANES) in 2176 participants (20-69 years of age). Normal audiometric thresholds were defined by pure-tone average (PTA4) of 0.5, 1.0, 2.0, 4.0 kHz ≤ 25 dBHL ...
Source: Hearing Research - December 7, 2017 Category: Audiology Authors: Spankovich C, Gonzalez VB, Su D, Bishop CE Tags: Hear Res Source Type: research

Frequency selectivity in macaque monkeys measured using a notched-noise method.
Abstract The auditory system is thought to process complex sounds through overlapping bandpass filters. Frequency selectivity as estimated by auditory filters has been well quantified in humans and other mammalian species using behavioral and physiological methodologies, but little work has been done to examine frequency selectivity in nonhuman primates. In particular, knowledge of macaque frequency selectivity would help address the recent controversy over the sharpness of cochlear tuning in humans relative to other animal species. The purpose of our study was to investigate the frequency selectivity of macaque m...
Source: Hearing Research - November 28, 2017 Category: Audiology Authors: Burton JA, Dylla ME, Ramachandran R Tags: Hear Res Source Type: research

A framework for testing and comparing binaural models.
This article discusses a number of current unresolved or disputed issues in binaural modelling, as well as some of the significant challenges in comparing binaural models with each other and with the experimental data. We introduce an auditory model framework, which we believe can become a useful infrastructure for resolving some of the current controversies. It operates models over the same paradigms that are used experimentally. The core of the proposed framework is an interface that connects three components irrespective of their underlying programming language: The experiment software, an auditory pathway model, and ta...
Source: Hearing Research - November 28, 2017 Category: Audiology Authors: Dietz M, Lestang JH, Majdak P, Stern RM, Marquardt T, Ewert SD, Hartmann WM, Goodman DFM Tags: Hear Res Source Type: research

The effect of simulated unilateral hearing loss on horizontal sound localization accuracy and recognition of speech in spatially separate competing speech.
Abstract Unilateral hearing loss (UHL) occurs in 25% of cases of congenital sensorineural hearing loss. Due to the unilaterally reduced audibility associated with UHL, everyday demanding listening situations may be disrupted despite normal hearing in one ear. The aim of this study was to quantify acute changes in recognition of speech in spatially separate competing speech and sound localization accuracy, and relate those changes to two levels of temporary induced UHL (UHL30 and UHL43; suffixes denote the average hearing threshold across 0.5, 1, 2, and 4 kHz) for 8 normal-hearing adults. A within-subject repe...
Source: Hearing Research - November 22, 2017 Category: Audiology Authors: Asp F, Jakobsson AM, Berninger E Tags: Hear Res Source Type: research

Minimally invasive laser vibrometry (MIVIB) with a floating mass transducer - A new method for objective evaluation of the middle ear demonstrated on stapes fixation.
ckx J Abstract Ossicular fixation through otosclerosis, chronic otitis media and other pathologies, especially tympanosclerosis, are treated by surgery if hearing aids fail as an alternative. However, the best hearing outcome is often based on knowledge of the degree and location of the fixation. Objective methods to quantify the degree and position of the fixation are largely lacking. Laser vibrometry is a known method to detect ossicular fixation but clinical applicability remains limited. A new method, minimally invasive laser vibrometry (MIVIB), is presented to quantify ossicle mobility using laser vibrometry ...
Source: Hearing Research - November 20, 2017 Category: Audiology Authors: Wales J, Gladiné K, Van de Heyning P, Topsakal V, von Unge M, Dirckx J Tags: Hear Res Source Type: research

Glutamate is down-regulated and tinnitus loudness-levels decreased following rTMS over auditory cortex of the left hemisphere: A prospective randomized single-blinded sham-controlled cross-over study.
Abstract Using a prospective randomized single-blinded sham-controlled cross-over design, we studied the efficacy of low frequency (1-Hz) repetitive transcranial magnetic stimulation (rTMS) over auditory cortex of the left temporal lobe as an experimental treatment modality for noise-induced tinnitus. Pre/post outcome measures for sham vs. active rTMS conditions included differential changes in tinnitus loudness, self-perceived changes in the Tinnitus Handicap Questionnaire (THQ), and neurochemical changes of brain metabolite concentrations using single voxel proton magnetic resonance spectroscopy ((1)H-MRS) obtai...
Source: Hearing Research - November 14, 2017 Category: Audiology Authors: Cacace AT, Hu J, Romero S, Xuan Y, Burkard RF, Tyler RS Tags: Hear Res Source Type: research

Effects of middle ear quasi-static stiffness on sound transmission quantified by a novel 3-axis optical force sensor.
This study investigates how middle ear transfer function is affected by stapes quasi-static stiffness of the ossicular chain. The stiffness of the middle ear is induced by a) using a novel fiber-optic 3-axis force sensor to quantify the quasi-static stiffness of the middle ear, and b) by artificial reduction of stapes mobility due to drying of the middle ear. METHODS: Middle ear transfer function, defined as the ratio of the stapes footplate velocity versus the ear canal sound pressure, was measured with a single point LDV in two conditions. First, a controlled palpation force was applied at the stapes head in two in-...
Source: Hearing Research - November 10, 2017 Category: Audiology Authors: Dobrev I, Sim JH, Aqtashi B, Huber AM, Linder T, Röösli C Tags: Hear Res Source Type: research

Performance of the Tinnitus Functional Index as a diagnostic instrument in a UK clinical population.
CONCLUSION: The TFI was confirmed to cover multiple symptom domains, measuring a multi-domain construct of tinnitus, and satisfies a range of psychometric requirements for a good clinical measure, including having excellent reliability, stability over time and sensitivity to individual differences in tinnitus severity. However, a modified seven-factor structure without the Auditory subscale (TFI-22) is recommended for calculating a global composite score for UK patients. Using patients' experience and Receiver Operator Characteristic analysis, a grading system was presented which identifies the distinct grades of tinnitus ...
Source: Hearing Research - November 9, 2017 Category: Audiology Authors: Fackrell K, Hall DA, Barry JG, Hoare DJ Tags: Hear Res Source Type: research

Development of the head, pinnae, and acoustical cues to sound location in a precocial species, the guinea pig (Cavia porcellus).
Abstract The morphology of the head and pinna shape the spatial and frequency dependence of sound propagation that give rise to the acoustic cues to sound source location. During early development, the physical dimensions of the head and pinna increase rapidly. Thus, the binaural (interaural time and level differences, ITD and ILD) and monaural (spectral shape) cues are also hypothesized to change rapidly. Complex interactions between the size and shape of the head and pinna limit the accuracy of simple acoustical models (e.g. spherical) and necessitate empirical measurements. Here, we measured the cues to locatio...
Source: Hearing Research - November 1, 2017 Category: Audiology Authors: Anbuhl KL, Benichoux V, Greene NT, Brown AD, Tollin DJ Tags: Hear Res Source Type: research

Plasticity in the auditory system.
Abstract Over the last 30 years a wide range of manipulations of auditory input and experience have been shown to result in plasticity in auditory cortical and subcortical structures. The time course of plasticity ranges from very rapid stimulus-specific adaptation to longer-term changes associated with, for example, partial hearing loss or perceptual learning. Evidence for plasticity as a consequence of these and a range of other manipulations of auditory input and/or its significance is reviewed, with an emphasis on plasticity in adults and in the auditory cortex. The nature of the changes in auditory cortex ass...
Source: Hearing Research - October 31, 2017 Category: Audiology Authors: Irvine DRF Tags: Hear Res Source Type: research

Effects of the cannabinoid CB1 agonist ACEA on salicylate ototoxicity, hyperacusis and tinnitus in guinea pigs.
Abstract Cannabinoids have been suggested as a therapeutic target for a variety of brain disorders. Despite the presence of their receptors throughout the auditory system, little is known about how cannabinoids affect auditory function. We sought to determine whether administration of arachidonyl-2'-chloroethylamide (ACEA), a highly-selective CB1 agonist, could attenuate a variety of auditory effects caused by prior administration of salicylate, and potentially treat tinnitus. We recorded cortical resting-state activity, auditory-evoked cortical activity and auditory brainstem responses (ABRs), from chronically-im...
Source: Hearing Research - October 31, 2017 Category: Audiology Authors: Berger JI, Coomber B, Hill S, Alexander SPH, Owen W, Palmer AR, Wallace MN Tags: Hear Res Source Type: research

The absence of resting-state high-gamma cross-frequency coupling in patients with tinnitus.
Abstract Tinnitus is a psychoacoustic phantom perception of currently unknown neuropathology. Despite a growing number of post-stimulus tinnitus studies, uncertainty still exists regarding the neural signature of tinnitus in the resting-state brain. In the present study, we used high-gamma cross-frequency coupling and a Granger causality analysis to evaluate resting-state electroencephalographic (EEG) data in healthy participants and patients with tinnitus. Patients with tinnitus lacked robust frontal delta-phase/central high-gamma-amplitude coupling that was otherwise clearly observed in healthy participants. Sin...
Source: Hearing Research - October 30, 2017 Category: Audiology Authors: Ahn MH, Hong SK, Min BK Tags: Hear Res Source Type: research

Cannula-based drug delivery to the guinea pig round window causes a lasting hearing loss that may be temporarily mitigated by BDNF.
This study determined the effect on hearing of placing a drug-delivery microcatheter on to the round window, and delivering either artificial perilymph (AP) or brain-derived neurotrophic factor (BDNF) via this catheter with a mini-osmotic pump. Auditory brainstem responses (ABRs) were monitored for 4 months after surgery, while the AP or BDNF was administered for the first month. The presence of the microcatheter - whether dry or when delivering AP or BDNF for 4 weeks - was associated with an increase in ABR thresholds of up to 15 dB, 16 weeks after implantation. This threshold shift was, in part, delayed by the deliv...
Source: Hearing Research - October 28, 2017 Category: Audiology Authors: Sale PJP, Uschakov A, Saief T, Rowe DP, Abbott CJ, Luu CD, Hampson AJ, O'Leary SJ, Sly DJ Tags: Hear Res Source Type: research

The effect of illusionary perception on mismatch negativity (MMN): An electroencephalography study.
Abstract Mismatch negativity (MMN) is a unique brain response elicited by any discernible change of features in a tone sequence. Although the occurrence of MMN is dependent upon the difference of a stimulus parameter, such as frequency or intensity, recent studies have suggested that MMN occurs as a result of a comparison between an internal representation created by perception and an incoming tone. The present study aimed to investigate MMN occurs based upon the physical properties of stimuli or as a result of the perception of the scale illusion. A scale illusion occurs during presentation of ascending and desce...
Source: Hearing Research - October 17, 2017 Category: Audiology Authors: Ono K, Yamasaki D, Altmann CF, Mima T Tags: Hear Res Source Type: research

Tinnitus with a normal audiogram: Role of high-frequency sensitivity and reanalysis of brainstem-response measures to avoid audiometric over-matching.
PMID: 29056432 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - October 14, 2017 Category: Audiology Authors: Guest H, Munro KJ, Plack CJ Tags: Hear Res Source Type: research

Auditory sequential accumulation of spectral information.
Abstract In many listening situations, information about the spectral content of a target sound may be distributed over time, and estimating the target spectrum requires efficient sequential processing. Listeners' ability to estimate the spectrum of a random-frequency, six-tone complex was investigated and the spectral content of the complex was revealed using a sequence of bursts. Whether each of the six tones was presented within each burst was determined at random according to a presentation probability. In separate conditions, the presentation probabilities (p) ranged from 0.2 to 1, the total number of bursts ...
Source: Hearing Research - October 11, 2017 Category: Audiology Authors: Shen Y Tags: Hear Res Source Type: research

An operating principle of the turtle utricle to detect wide dynamic range.
Abstract The utricle encodes both static information such as head orientation, and dynamic information such as vibrations. It is not well understood how the utricle can encode both static and dynamic information for a wide dynamic range (from 2 times the gravitational acceleration; from DC to > 1000 Hz vibrations). Using computational models of the hair cells in the turtle utricle, this study presents an explanation on how the turtle utricle encodes stimulations over such a wide dynamic range. Two hair bundles were modeled using the finite element method-one representing the striolar hair cell (C...
Source: Hearing Research - October 9, 2017 Category: Audiology Authors: Nam JH Tags: Hear Res Source Type: research

Corrigendum to "Place dependent stimulation rates improve pitch perception in cochlear implantees with single-sided deafness" [Hear. Res. 339 (2016) 94-103].
Corrigendum to "Place dependent stimulation rates improve pitch perception in cochlear implantees with single-sided deafness" [Hear. Res. 339 (2016) 94-103]. Hear Res. 2017 Oct;354:109 Authors: Rader T, Döge J, Adel Y, Weissgerber T, Baumann U PMID: 28958391 [PubMed - in process] (Source: Hearing Research)
Source: Hearing Research - September 30, 2017 Category: Audiology Authors: Rader T, Döge J, Adel Y, Weissgerber T, Baumann U Tags: Hear Res Source Type: research

Diversity of bilateral synaptic assemblies for binaural computation in midbrain single neurons.
This study examines the bilateral synaptic assemblies and binaural computation (or integration) in the central nucleus of the inferior colliculus (ICc) of the auditory midbrain, a key convergent center. Using in-vivo whole-cell patch-clamp, the excitatory and inhibitory postsynaptic potentials (EPSPs/IPSPs) of single ICc neurons to contralateral, ipsilateral and bilateral stimulation were recorded. According to the contralateral and ipsilateral EPSP/IPSP, 7 types of bilateral synaptic assemblies were identified. These include EPSP-EPSP (EE), E-IPSP (EI), E-no response (EO), II, IE, IO and complex-mode (CM) neurons. The CM ...
Source: Hearing Research - September 18, 2017 Category: Audiology Authors: He N, Kong L, Lin T, Wang S, Liu X, Qi J, Yan J Tags: Hear Res Source Type: research

Standard-interval size affects interval-discrimination thresholds for pure-tone melodic pitch intervals.
Abstract Our ability to discriminate between pitch intervals of different sizes is not only an important aspect of speech and music perception, but also a useful means of evaluating higher-level pitch perception. The current study examined how pitch-interval discrimination was affected by the size of the intervals being compared, and by musical training. Using an adaptive procedure, pitch-interval discrimination thresholds were measured for sequentially presented pure-tone intervals with standard intervals of 1 semitone (minor second), 6 semitones (the tri-tone), and 7 semitones (perfect fifth). Listeners were cla...
Source: Hearing Research - September 18, 2017 Category: Audiology Authors: McClaskey CM Tags: Hear Res Source Type: research

Language experience-dependent advantage in pitch representation in the auditory cortex is limited to favorable signal-to-noise ratios.
Abstract Long-term experience enhances neural representation of temporal attributes of pitch in the brainstem and auditory cortex in favorable listening conditions. Herein we examine whether cortical pitch mechanisms shaped by language experience are more resilient to degradation in background noise, and exhibit greater binaural release from masking (BRM). Cortical pitch responses (CPR) were recorded from Mandarin- and English-speaking natives using a Mandarin word exhibiting a high rising pitch (/yi(2)/). Stimuli were presented diotically in Quiet, and in noise at +5, and 0 dB SNR. CPRs were also record...
Source: Hearing Research - September 14, 2017 Category: Audiology Authors: Suresh CH, Krishnan A, Gandour JT Tags: Hear Res Source Type: research

Amplitude modulation rate dependent topographic organization of the auditory steady-state response in human auditory cortex.
Abstract Periodic modulations of an acoustic feature, such as amplitude over a certain frequency range, leads to phase locking of neural responses to the envelope of the modulation. Using electrophysiological methods this neural activity pattern, also called the auditory steady-state response (aSSR), is visible following frequency transformation of the evoked response as a clear spectral peak at the modulation frequency. Despite several studies employing the aSSR that show, for example, strongest responses for ∼40 Hz and an overall right-hemispheric dominance, it has not been investigated so far to what e...
Source: Hearing Research - September 11, 2017 Category: Audiology Authors: Weisz N, Lithari C Tags: Hear Res Source Type: research

Emotional recognition of dynamic facial expressions before and after cochlear implantation in adults with progressive deafness.
Abstract Visual processing has been extensively explored in deaf subjects in the context of verbal communication, through the assessment of speech reading and sign language abilities. However, little is known about visual emotional processing in adult progressive deafness, and after cochlear implantation. The goal of our study was thus to assess the influence of acquired post-lingual progressive deafness on the recognition of dynamic facial emotions that were selected to express canonical fear, happiness, sadness, and anger. A total of 23 adults with post-lingual deafness separated into two groups; those assessed ...
Source: Hearing Research - August 31, 2017 Category: Audiology Authors: Ambert-Dahan E, Giraud AL, Mecheri H, Sterkers O, Mosnier I, Samson S Tags: Hear Res Source Type: research

Effects of attention on the speech reception threshold and pupil response of people with impaired and normal hearing.
Abstract For people with hearing difficulties, following a conversation in a noisy environment requires substantial cognitive processing, which is often perceived as effortful. Recent studies with normal hearing (NH) listeners showed that the pupil dilation response, a measure of cognitive processing load, is affected by 'attention related' processes. How these processes affect the pupil dilation response for hearing impaired (HI) listeners remains unknown. Therefore, the current study investigated the effect of auditory attention on various pupil response parameters for 15 NH adults (median age 51 yrs.) and 15 ad...
Source: Hearing Research - August 30, 2017 Category: Audiology Authors: Koelewijn T, Versfeld NJ, Kramer SE Tags: Hear Res Source Type: research

The effect of blast overpressure on the mechanical properties of a chinchilla tympanic membrane.
Abstract The rupture of tympanic membrane (TM) has long been viewed as an indicator of blast injury, especially for hearing loss. However, little is known about damage to the TM caused by blast with pressure lower than the rupture threshold. In this paper, we present our study on the effect of blast overpressure on the static mechanical properties of TM. Chinchilla was used as the animal model and exposed to multiple blasts with pressures lower than the rupture threshold of the TM. Using a micro-fringe projection method, we observed the alteration of the static mechanical properties of post-blast chinchilla's TMs ...
Source: Hearing Research - August 18, 2017 Category: Audiology Authors: Liang J, Yokell ZA, Nakmaili DU, Gan RZ, Lu H Tags: Hear Res Source Type: research

Strain-specific differences in the development of neuronal excitability in the mouse ventral nucleus of the trapezoid body.
Abstract This investigation compared the development of neuronal excitability in the ventral nucleus of the trapezoid body (VNTB) between two strains of mice with differing progression rates for age-related hearing loss. In contrast to CBA/Ca (CBA) mice, the C57BL/6J (C57) strain are subject to hearing loss from a younger age and are more prone to damage from sound over-exposure. Higher firing rates in the medial olivocochlear system (MOC) are associated with protection from loud sounds and these cells are located in the VNTB. We postulated that reduced neuronal firing of the MOC in C57 mice could contribute to he...
Source: Hearing Research - August 18, 2017 Category: Audiology Authors: Sinclair JL, Barnes-Davies M, Kopp-Scheinpflug C, Forsythe ID Tags: Hear Res Source Type: research

No auditory experience, no tinnitus: Lessons from subjects with  congenital- and acquired single-sided deafness.
This study enrolled 20 subjects with congenital SSD and 44 subjects with acquired SSD and examined the presence and characteristics of tinnitus in the groups. None of the 20 subjects with congenital SSD perceived tinnitus on the affected side, whereas 30 of 44 subjects with acquired SSD experienced tinnitus on the affected side. Additionally, there were significant positive correlations between tinnitus characteristics and the audiometric characteristics of the SSD. In accordance with the findings of the recent animal study, tinnitus was absent in subjects with congenital SSD, but relatively frequent in subjects with acqui...
Source: Hearing Research - August 15, 2017 Category: Audiology Authors: Lee SY, Nam DW, Koo JW, De Ridder D, Vanneste S, Song JJ Tags: Hear Res Source Type: research

Improved middle-ear soft-tissue visualization using synchrotron radiation phase-contrast imaging.
Abstract High resolution images are used as a basis for finite-element modeling of the middle-ear structures to study their biomechanical function. Commonly used imaging techniques such as micro-computed tomography (CT) and optical microscopy require extensive sample preparation, processing or staining using contrast agents to achieve sufficient soft-tissue contrast. We compare imaging of middle-ear structures in unstained, non-decalcified human temporal bones using conventional absorption-contrast micro-CT and using synchrotron radiation phase-contrast imaging (SR-PCI). Four cadaveric temporal bones were imaged u...
Source: Hearing Research - August 5, 2017 Category: Audiology Authors: Elfarnawany M, Rohani SA, Ghomashchi S, Allen DG, Zhu N, Agrawal SK, Ladak HM Tags: Hear Res Source Type: research

Speech reception with different bilateral directional processing schemes: Influence of binaural hearing, audiometric asymmetry, and acoustic scenario.
Abstract Hearing aid (HA) users can differ markedly in their benefit from directional processing (or beamforming) algorithms. The current study therefore investigated candidacy for different bilateral directional processing schemes. Groups of elderly listeners with symmetric (N = 20) or asymmetric (N = 19) hearing thresholds for frequencies below 2 kHz, a large spread in the binaural intelligibility level difference (BILD), and no difference in age, overall degree of hearing loss, or performance on a measure of selective attention took part. Aided speech reception was measured using virtua...
Source: Hearing Research - July 29, 2017 Category: Audiology Authors: Neher T, Wagener KC, Latzel M Tags: Hear Res Source Type: research