Reply to "Critical examination of the article: Impulse noise injury prediction based on the cochlear energy".
Reply to "Critical examination of the article: Impulse noise injury prediction based on the cochlear energy". Hear Res. 2017 Mar 30;: Authors: Zagadou B, Chan P, Ho K, Shelley D PMID: 28390736 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - March 30, 2017 Category: Audiology Authors: Zagadou B, Chan P, Ho K, Shelley D Tags: Hear Res Source Type: research

The intelligibility of speech in a harmonic masker varying in fundamental frequency contour, broadband temporal envelope, and spatial location.
he ML Abstract Differences in fundamental frequency (F0), modulations in the masker envelope, and differences in spatial location between a speech target and a masker can improve speech intelligibility in cocktail-party situations. These cues have been thoroughly investigated independently and associated with unmasking mechanisms: F0 segregation, temporal dip listening and spatial unmasking, respectively. Two experiments were conducted to examine whether F0 segregation interacts with spatial unmasking (experiment 1) or temporal modulations in the masker envelope (experiment 2) by measuring speech reception thresho...
Source: Hearing Research - March 29, 2017 Category: Audiology Authors: Leclère T, Lavandier M, Deroche ML Tags: Hear Res Source Type: research

Modulation of auditory percepts by transcutaneous electrical stimulation.
Abstract Transcutaneous, electrical stimulation with electrodes placed on the mastoid processes represents a specific way to elicit vestibular reflexes in humans without active or passive subject movements, for which the term galvanic vestibular stimulation was coined. It has been suggested that galvanic vestibular stimulation mainly affects the vestibular periphery, but whether vestibular hair cells, vestibular afferents, or a combination of both are excited, is still a matter of debate. Galvanic vestibular stimulation has been in use since the late 18(th) century, but despite the long-known and well-documented e...
Source: Hearing Research - March 17, 2017 Category: Audiology Authors: Ueberfuhr MA, Braun A, Wiegrebe L, Grothe B, Drexl M Tags: Hear Res Source Type: research

Comparison of perceptual properties of auditory streaming between spectral and amplitude modulation domains.
Abstract The two-tone sequence (ABA_), which comprises two different sounds (A and B) and a silent gap, has been used to investigate how the auditory system organizes sequential sounds depending on various stimulus conditions or brain states. Auditory streaming can be evoked by differences not only in the tone frequency ("spectral cue": ΔFTONE, TONE condition) but also in the amplitude modulation rate ("AM cue": ΔFAM, AM condition). The aim of the present study was to explore the relationship between the perceptual properties of auditory streaming for the TONE and AM conditions. A s...
Source: Hearing Research - March 17, 2017 Category: Audiology Authors: Yamagishi S, Otsuka S, Furukawa S, Kashino M Tags: Hear Res Source Type: research

Speech intelligibility and subjective benefit in single-sided deaf adults after cochlear implantation.
, Illg A Abstract Treatment with cochlear implants (CIs) in single-sided deaf individuals started less than a decade ago. CIs can successfully reduce incapacitating tinnitus on the deaf ear and allow, so some extent, the restoration of binaural hearing. Until now, systematic evaluations of subjective CI benefit in post-lingually single-sided deaf individuals and analyses of speech intelligibility outcome for the CI in isolation have been lacking. For the prospective part of this study, the Bern Benefit in Single-Sided Deafness Questionnaire (BBSS) was administered to 48 single-sided deaf CI users to evaluate the s...
Source: Hearing Research - March 8, 2017 Category: Audiology Authors: Finke M, Strauß-Schier A, Kludt E, Büchner A, Illg A Tags: Hear Res Source Type: research

Isolating spectral cues in amplitude and quasi-frequency modulation discrimination by reducing stimulus duration.
This study investigated the psychophysical effects of distortion products in a listening task traditionally used to estimate the bandwidth of phase sensitivity. For a 2000 Hz carrier, estimates of modulation depth necessary to discriminate amplitude modulated (AM) tones and quasi-frequency modulated (QFM) were measured in a two interval forced choice task as a function modulation frequency. Temporal modulation transfer functions were often non-monotonic at modulation frequencies above 300 Hz. This was likely to be due to a spectral cue arising from the interaction of auditory distortion products and the lower sid...
Source: Hearing Research - March 7, 2017 Category: Audiology Authors: Borucki E, Berg BG Tags: Hear Res Source Type: research

Contributions of sensory tuning to auditory-vocal interactions in marmoset auditory cortex.
Abstract During speech, humans continuously listen to their own vocal output to ensure accurate communication. Such self-monitoring is thought to require the integration of information about the feedback of vocal acoustics with internal motor control signals. The neural mechanism of this auditory-vocal interaction remains largely unknown at the cellular level. Previous studies in naturally vocalizing marmosets have demonstrated diverse neural activities in auditory cortex during vocalization, dominated by a vocalization-induced suppression of neural firing. How underlying auditory tuning properties of these neuron...
Source: Hearing Research - March 7, 2017 Category: Audiology Authors: Eliades SJ, Wang X Tags: Hear Res Source Type: research

Laser-capture micro dissection combined with next-generation sequencing analysis of cell type-specific deafness gene expression in the mouse cochlea.
Abstract Cochlear implantation (CI), which directly stimulates the cochlear nerves, is the most effective and widely used medical intervention for patients with severe to profound sensorineural hearing loss. The etiology of the hearing loss is speculated to have a major influence of CI outcomes, particularly in cases resulting from mutations in genes preferentially expressed in the spiral ganglion region. To elucidate precise gene expression levels in each part of the cochlea, we performed laser-capture micro dissection in combination with next generation-sequencing analysis and determined the expression levels of...
Source: Hearing Research - March 1, 2017 Category: Audiology Authors: Nishio SY, Takumi Y, Usami SI Tags: Hear Res Source Type: research

Indexing cortical entrainment to natural speech at the phonemic level: Methodological considerations for applied research.
Abstract Speech is central to human life. As such, any delay or impairment in receptive speech processing can have a profoundly negative impact on the social and professional life of a person. Thus, being able to assess the integrity of speech processing in different populations is an important goal. Current standardized assessment is mostly based on psychometric measures that do not capture the full extent of a person's speech processing abilities and that are difficult to administer in some subjects groups. A potential alternative to these tests would be to derive "direct", objective measures of speech...
Source: Hearing Research - February 24, 2017 Category: Audiology Authors: Di Liberto GM, Lalor EC Tags: Hear Res Source Type: research

On the relation between pitch and level.
Abstract Pitch is the perceptual dimension along which musical notes are ordered from low to high. It is often described as the perceptual correlate of the periodicity of the sound's waveform. Previous reports have shown that pitch can depend slightly on sound level. We wanted to verify that these observations reflect genuine changes in perceived pitch, and were not due to procedural factors or confusion between dimensions of pitch and level. We first conducted a systematic pitch matching task and confirmed that the pitch of low frequency pure tones, but not complex tones, decreases by an amount equivalent to a ch...
Source: Hearing Research - February 22, 2017 Category: Audiology Authors: Zheng Y, Brette R Tags: Hear Res Source Type: research

The auditory evoked-gamma response and its relation with the N1m.
This study explored the patterns of oscillatory activity that underpin the N1m auditory evoked response. Evoked gamma activity is a small and relatively rarely-reported component of the auditory evoked response, and the objective of this work was to determine how this component relates to the larger and more prolonged changes in lower frequency bands. An event-related beamformer analysis of MEG data from monaural click stimulation was used to reconstruct volumetric images and virtual electrode time series. Group analysis of localisations showed that activity in the gamma band originated from a source that was more medial t...
Source: Hearing Research - February 21, 2017 Category: Audiology Authors: Witton C, Eckert MA, Stanford IM, Gascoyne LE, Furlong PL, Worthen SF, Hillebrand A Tags: Hear Res Source Type: research

Association of TagSNP in lncRNA HOTAIR with susceptibility to noise-induced hearing loss in a Chinese population.
CONCLUSIONS: The genetic polymorphism within HOTAIR gene may play a crucial role in the occurrence and development of NIHL. PMID: 28223190 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - February 17, 2017 Category: Audiology Authors: Wang B, Ding E, Shen H, Wang J, Sun K, Chen S, Han L, Zhang H, Zhu B, Xu M Tags: Hear Res Source Type: research

Pitch Ranking with Different Virtual Channel Configurations in Electrical Hearing.
In this study, we looked at pitch ranking in cochlear implant users with QPVC, VTP, and MPVC configurations to determine if place pitch shifts similarly across the cochlea or if any of the stimulation modes shift non-monotonically. Results suggest that MPVC and VTP stimulation provide a consistent monotonic shift across cochlear positions while the place shift provided by QPVCs was more variable. The use of VTP stimulation would be recommended instead of QPVC for a speech processing strategy. PMID: 28216122 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - February 15, 2017 Category: Audiology Authors: Padilla M, Stupak N, Landsberger DM Tags: Hear Res Source Type: research

Ablation of the auditory cortex results in changes in the expression of neurotransmission-related mRNAs in the cochlea.
In this report, we show that descending connections from AC to olivocochlear neurons are necessary to regulate the expression of molecules involved in cochlear afferent signaling. RT-qPCR was performed in rats at 1, 7 and 15 days after unilateral ablation of the AC, and analyzed the time course changes in gene transcripts involved in neurotransmission at the first auditory synapse. This included the glutamate metabolism enzyme glutamate decarboxylase 1 (glud1) and AMPA glutamate receptor subunits GluA2-4. In addition, gene transcripts involved in efferent regulation of type I spiral ganglion neuron (SGN) excitability media...
Source: Hearing Research - February 15, 2017 Category: Audiology Authors: Lamas V, Juiz JM, Merchán MA Tags: Hear Res Source Type: research

The pattern and degree of capsular fibrous sheaths surrounding cochlear electrode arrays.
Abstract An inflammatory tissue reaction around the electrode array of a cochlear implant (CI) is common, in particular at the electrode insertion region (cochleostomy) where mechanical trauma often occurs. However, the factors determining the amount and causes of fibrous reaction surrounding the stimulating electrode, especially medially near the perimodiolar location, are unclear. Temporal bone (TB) specimens from patients who had undergone cochlear implantation during life with either Advanced Bionics (AB) Clarion (TM) or HiRes90K(TM) (Sylmar, CA, USA) devices that have a half-band and a pre-curved electrode, o...
Source: Hearing Research - February 15, 2017 Category: Audiology Authors: Ishai R, Herrmann BS, Nadol JB, Quesnel AM Tags: Hear Res Source Type: research

Population responses in primary auditory cortex simultaneously represent the temporal envelope and periodicity features in natural speech.
Abstract Speech perception relies on a listener's ability to simultaneously resolve multiple temporal features in the speech signal. Little is known regarding neural mechanisms that enable the simultaneous coding of concurrent temporal features in the speech signal. Here we show that two categories of temporal features in speech, the low-frequency speech envelope and periodicity cues, are processed by distinct neural mechanisms within the same population of cortical neurons. We measured population activity in primary auditory cortex of anesthetized guinea pig in response to three variants of a naturally produced s...
Source: Hearing Research - February 15, 2017 Category: Audiology Authors: Abrams DA, Nicol T, White-Schwoch T, Hartmann M, Zecker S, Kraus N Tags: Hear Res Source Type: research

The relation between ECAP measurements and the effect of rate on behavioral thresholds in cochlear implant users.
Abstract It has been shown that electrically evoked compound action potential (ECAP) thresholds are not sufficiently predictive of behavioral thresholds to allow their use as a totally objective method to program a cochlear implant. Previous animal studies have shown that two other ECAP parameters (the ECAP amplitude growth slope and the effect on ECAPs of changing the phase duration (PD) or interphase gap (IPG)), and the way that behavioral thresholds change with increasing rate of stimulation, are associated with cochlear health. This experiment tested the hypotheses that a) the degree to which behavioral thresh...
Source: Hearing Research - February 13, 2017 Category: Audiology Authors: McKay CM, Smale N Tags: Hear Res Source Type: research

Speech-in-noise perception in musicians: a review.
Abstract The ability to understand speech in the presence of competing sound sources is an important neuroscience question in terms of how the nervous system solves this computational problem. It is also a critical clinical problem that disproportionally affects the elderly, children with language-related learning disorders, and those with hearing loss. Recent evidence that musicians have an advantage on this multifaceted skill has led to the suggestion that musical training might be used to improve or delay the decline of speech-in-noise (SIN) function. However, enhancements have not been universally reported, no...
Source: Hearing Research - February 13, 2017 Category: Audiology Authors: Coffey EB, Mogilever N, Zatorre RJ Tags: Hear Res Source Type: research

Genetic variants in the peripheral auditory system significantly affect adult cochlear implant performance.
CONCLUSION: Etiological diagnosis of deafness including genetic testing is the single largest predictor of postoperative speech outcomes in adult cochlear implant recipients. A detailed understanding of the genetic underpinning of hearing loss will better inform pre-implant counseling. The method presented here should serve as a guide for further research into the molecular physiology of the peripheral auditory system and cochlear implants. PMID: 28213135 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - February 13, 2017 Category: Audiology Authors: Shearer AE, Eppsteiner RW, Frees K, Tejani V, Sloan-Heggen CM, Brown C, Abbas P, Dunn C, Hansen MR, Gantz BJ, Smith RJ Tags: Hear Res Source Type: research

Stapes displacement and intracochlear pressure in response to very high level, low frequency sounds.
Abstract The stapes is held in the oval window by the stapedial annular ligament (SAL), which restricts total peak-to-peak displacement of the stapes. Previous studies have suggested that for moderate (
Source: Hearing Research - February 7, 2017 Category: Audiology Authors: Greene NT, Jenkins HA, Tollin DJ, Easter JR Tags: Hear Res Source Type: research

Auditory perceptual load: A review.
Abstract Selective attention is a crucial mechanism in everyday life, allowing us to focus on a portion of incoming sensory information at the expense of other less relevant stimuli. The circumstances under which irrelevant stimuli are successfully ignored have been a topic of scientific interest for several decades now. Over the last 20 years, the perceptual load theory (e.g. Lavie, 1995) has provided one robust framework for understanding these effects within the visual modality. The suggestion is that successful selection depends on the perceptual demands imposed by the task-relevant information. However, less ...
Source: Hearing Research - February 7, 2017 Category: Audiology Authors: Murphy S, Spence C, Dalton P Tags: Hear Res Source Type: research

Abnormal regional activity and functional connectivity in resting-state brain networks associated with etiology confirmed unilateral pulsatile tinnitus in the early stage of disease.
This study was designed to demonstrate the functional network alterations in the patients with pulsatile tinnitus (PT). In this study, we recruited 45 patients with unilateral PT in the early stage of disease (less than 48 months of disease duration) and 45 normal controls. We used regional homogeneity (ReHo) and seed-based FC computational methods to reveal resting-state brain activity features associated with pulsatile tinnitus. Compared with healthy controls, PT patients showed regional abnormalities mainly in the left middle occipital gyrus (MOG), posterior cingulate gyrus (PCC), precuneus and right anterior insula (AI...
Source: Hearing Research - February 6, 2017 Category: Audiology Authors: Lv H, Zhao P, Liu Z, Li R, Zhang L, Wang P, Yan F, Liu L, Wang G, Zeng R, Li T, Dong C, Gong S, Wang Z Tags: Hear Res Source Type: research

Intelligibility in speech maskers with a binaural cochlear implant sound coding strategy inspired by the contralateral medial olivocochlear reflex.
on BS Abstract We have recently proposed a binaural cochlear implant (CI) sound processing strategy inspired by the contralateral medial olivocochlear reflex (the MOC strategy) and shown that it improves intelligibility in steady-state noise (Lopez-Poveda et al., 2016, Ear Hear 37:e138-e148). The aim here was to evaluate possible speech-reception benefits of the MOC strategy for speech maskers, a more natural type of interferer. Speech reception thresholds (SRTs) were measured in six bilateral and two single-sided deaf CI users with the MOC strategy and with a standard (STD) strategy. SRTs were measured in unilate...
Source: Hearing Research - February 6, 2017 Category: Audiology Authors: Lopez-Poveda EA, Eustaquio-Martín A, Stohl JS, Wolford RD, Schatzer R, Gorospe JM, Ruiz SS, Benito F, Wilson BS Tags: Hear Res Source Type: research

Identification of induced and naturally occurring conductive hearing loss in mice using bone conduction.
In this report, we investigate the use of air- and bone-conducted evoked auditory brainstem responses to perform a similar separation in mice. We describe a technique by which we stimulate the mouse ear both acoustically and via whole-head vibration. We investigate the sensitivity of this technique to conductive hearing loss by introducing middle-ear lesions in normal hearing mice. We also use the technique to investigate the presence of an age-related conductive hearing loss in a common mouse model of presbycusis, the BALB/c mouse. PMID: 28167132 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - February 2, 2017 Category: Audiology Authors: Chhan D, McKinnon ML, Rosowski JJ Tags: Hear Res Source Type: research

Auditory brainstem response latency in forward masking, a marker of sensory deficits in listeners with normal hearing thresholds.
Abstract In rodent models, acoustic exposure too modest to elevate hearing thresholds can nonetheless cause auditory nerve fiber deafferentation, interfering with the coding of supra-threshold sound. Low-spontaneous rate nerve fibers, important for encoding acoustic information at supra-threshold levels and in noise, are more susceptible to degeneration than high-spontaneous rate fibers. The change in auditory brainstem response (ABR) wave-V latency with noise level has been shown to be associated with auditory nerve deafferentation. Here, we measured ABR in a forward masking paradigm and evaluated wave-V latency ...
Source: Hearing Research - January 31, 2017 Category: Audiology Authors: Mehraei G, Paredes Gallardo A, Shinn-Cunningham BG, Dau T Tags: Hear Res Source Type: research

Analytical and numerical modeling of the hearing system: advances towards the assessment of hearing damage.
Abstract Hearing is an extremely complex phenomenon, involving a large number of interrelated variables that are difficult to measure in vivo. In order to investigate such process under simplified and well-controlled conditions, models of sound transmission have been developed through many decades of research. The value of modeling the hearing system is not only to explain the normal function of the hearing system and account for experimental and clinical observations, but to simulate a variety of pathological conditions that lead to hearing damage and hearing loss, as well as for development of auditory implants,...
Source: Hearing Research - January 31, 2017 Category: Audiology Authors: De Paolis A, Bikson M, Nelson JT, de Ru JA, Packer M, Cardoso L Tags: Hear Res Source Type: research

Prevalence of hearing loss and tinnitus in Iraq and Afghanistan veterans: A Chronic Effects of Neurotrauma Consortium study.
Abstract The purpose of this study was to describe the prevalence of hearing loss and tinnitus in a cohort of Iraq and Afghanistan veterans (IAV) with common post-deployment conditions, including traumatic brain injury (TBI), post-traumatic stress disorder (PTSD), and other typical post-concussive conditions such as headaches and vertigo/dizziness. This retrospective observational study used data from the national Veterans Health Administration (VA) data repository from fiscal years 2001-2014. Veteran data was included if there were at least three years of VA care, with one or more years of care in 2007 or after. ...
Source: Hearing Research - January 29, 2017 Category: Audiology Authors: Swan AA, Nelson JT, Swiger B, Jaramillo CA, Eapen BC, Packer M, Pugh MJ Tags: Hear Res Source Type: research

Frequency-dependent fine structure in the frequency-following response: The byproduct of multiple generators.
Abstract The frequency-following response (FFR) is an auditory-evoked response recorded at the scalp that captures the spectrotemporal properties of tonal stimuli. Previous investigations report that the amplitude of the FFR fluctuates as a function of stimulus frequency, a phenomenon thought to reflect multiple neural generators phase-locking to the stimulus with different response latencies. When phase-locked responses are offset by different latencies, constructive and destructive phase interferences emerge in the volume-conducted signals, culminating in an attenuation or amplification of the scalp-recorded res...
Source: Hearing Research - January 26, 2017 Category: Audiology Authors: Tichko P, Skoe E Tags: Hear Res Source Type: research

Auditory-visual integration in fields of the auditory cortex.
Abstract While multimodal interactions have been known to exist in the early sensory cortices, the response properties and spatiotemporal organization of these interactions are poorly understood. To elucidate the characteristics of multimodal sensory interactions in the cerebral cortex, neuronal responses to visual stimuli with or without auditory stimuli were investigated in core and belt fields of guinea pig auditory cortex using real-time optical imaging with a voltage-sensitive dye. On average, visual responses consisted of short excitation followed by long inhibition. Although visual responses were observed i...
Source: Hearing Research - January 19, 2017 Category: Audiology Authors: Kubota M, Sugimoto S, Hosokawa Y, Ojima H, Horikawa J Tags: Hear Res Source Type: research

Development and validation of the Speech Reception in Noise (SPRINT) Test.
Abstract Since 1992, the Speech Recognition in Noise Test, or SPRINT, has been the standard speech-in-noise test for assessing auditory fitness-for-duty of US Army Soldiers with hearing loss. The original SPRINT test consisted of 200 monosyllabic words presented at a Signal-to-Noise Ratio (SNR) of +9 dB in the presence of a six-talker babble noise. Normative data for the test was collected on 319 hearing impaired Soldiers, and a procedure for making recommendations about the disposition of military personnel on the basis of their SPRINT score and their years of experience was developed and implemented as part of U...
Source: Hearing Research - January 18, 2017 Category: Audiology Authors: Brungart DS, Walden B, Cord M, Phatak S, Theodoroff SM, Griest S, Grant KW Tags: Hear Res Source Type: research

Informational masking and the effects of differences in fundamental frequency and fundamental-frequency contour on phonetic integration in a formant ensemble.
This study explored the effects on speech intelligibility of across-formant differences in fundamental frequency (ΔF0) and F0 contour. Sentence-length speech analogues were presented dichotically (left = F1 + F3; right = F2), either alone or-because competition usually reveals grouping cues most clearly-accompanied in the left ear by a competitor for F2 (F2C) that listeners must reject to optimize recognition. F2C was created by inverting the F2 frequency contour. In experiment 1, all left-ear formants shared the same constant F0 and ΔF0F2 was 0 or ±4 semitones. In experimen...
Source: Hearing Research - January 17, 2017 Category: Audiology Authors: Summers RJ, Bailey PJ, Roberts B Tags: Hear Res Source Type: research

Metabotropic glutamate and GABA receptors modulate cellular excitability and glutamatergic transmission in chicken cochlear nucleus angularis neurons.
Abstract Neurons in the avian cochlear nucleus angularis (NA) receive glutamatergic input from the auditory nerve, and GABAergic input from the superior olivary nucleus. Physiologically heterogeneous, NA neurons perform multiple functions including encoding sound intensity information. Using in vitro whole-cell patch recordings from acute brain slices and immunohistochemistry staining, we investigated neuromodulation mediated by metabotropic glutamate and GABA receptors (mGluRs and GABABRs) in NA neurons. Based on their intrinsic firing patterns in response to somatic current injections, NA neurons were classified...
Source: Hearing Research - January 15, 2017 Category: Audiology Authors: Shi W, Lu Y Tags: Hear Res Source Type: research

Adding simultaneous stimulating channels to reduce power consumption in cochlear implants.
a W Abstract Sound coding strategies for Cochlear Implant (CI) listeners can be used to control the trade-off between speech performance and power consumption. Most commercial CI strategies use non-simultaneous channel stimulation, stimulating only one electrode at a time. One could add parallel simultaneous stimulating channels such that the electrical interaction between channels is increased. This would produce spectral smearing, because the electrical fields of the simultaneous stimulated channels interact, but also power savings. The parallel channels produce a louder sensation than sequential stimulation. To...
Source: Hearing Research - January 15, 2017 Category: Audiology Authors: Langner F, Saoji A, Büchner A, Nogueira W Tags: Hear Res Source Type: research

Using acoustic reflex threshold, auditory brainstem response and loudness judgments to investigate changes in neural gain following acute unilateral deprivation in normal hearing adults.
Abstract Unilateral auditory deprivation induces a reduction in the acoustic reflex threshold (ART) and an increase in loudness. These findings have been interpreted as a compensatory change in neural gain, governed by changes in excitatory and inhibitory neural inputs. There is also evidence to suggest that changes in neural gain can be measured using the auditory brainstem response (ABR). The present study extended Munro et al. (2014) [J. Acoust. Soc. Am. 135, 315-322] by investigating changes after 4 days of unilateral earplug use to: (i) ART, (ii) auditory brainstem response (ABR) and (iii) loudness. Because c...
Source: Hearing Research - January 12, 2017 Category: Audiology Authors: Brotherton H, Plack CJ, Schaette R, Munro KJ Tags: Hear Res Source Type: research

Broadening the Phenotype of DFNB28: Mutations in TRIOBP are associated with Moderate, Stable Hereditary Hearing Impairment.
Abstract DFNB28 is characterized by prelingual, severe to profound sensorineural hearing impairment (HI). It is associated with mutations in exon 6 and 7 of TRIOBP and has not been reported in the European population. Here, we describe two isolated cases of Dutch origin with congenital, moderate HI and compound heterozygous mutations in TRIOBP. Three of the mutations are novel, one nonsense mutation (c.5014G>T (p.Gly1672*)) and two frameshift mutations (c.2653del (p.Arg885Alafs*120) and c.3460_3461del (p.Leu1154Alafs*29)). The fourth mutation is the known c.3232dup (p.Arg1078Profs*6) mutation. Longitudinal audi...
Source: Hearing Research - January 11, 2017 Category: Audiology Authors: Wesdorp M, van de Kamp JM, Hensen EF, Schraders M, Oostrik J, Yntema HG, Feenstra I, Admiraal RJ, Kunst HP, Tekin M, Kanaan M, Kremer H, Pennings RJ Tags: Hear Res Source Type: research

Voice Emotion Perception and Production in Cochlear Implant Users.
Abstract Voice emotion is a fundamental component of human social interaction and social development. Unfortunately, cochlear implant users are often forced to interface with highly degraded prosodic cues as a result of device constraints in extraction, processing, and transmission. As such, individuals with cochlear implants frequently demonstrate significant difficulty in recognizing voice emotions in comparison to their normal hearing counterparts. Cochlear implant-mediated perception and production of voice emotion is an important but relatively understudied area of research. However, a rich understanding of t...
Source: Hearing Research - January 10, 2017 Category: Audiology Authors: Jiam NT, Caldwell M, Deroche ML, Chatterjee M, Limb CJ Tags: Hear Res Source Type: research

Estimation of the Young's modulus of the human pars tensa using in-situ pressurization and inverse finite-element analysis.
Abstract Finite-element models of the tympanic membrane are sensitive to the Young's modulus of the pars tensa. The aim of this work is to estimate the Young's modulus under a different experimental paradigm than currently used on the human tympanic membrane. These additional values could potentially be used by the auditory biomechanics community for building consensus. The Young's modulus of the human pars tensa was estimated through inverse finite-element modelling of an in-situ pressurization experiment. The experiments were performed on three specimens with a custom-built pressurization unit at a quasi-static ...
Source: Hearing Research - January 9, 2017 Category: Audiology Authors: Rohani SA, Ghomashchi S, Agrawal SK, Ladak HM Tags: Hear Res Source Type: research

The path of a click stimulus from ear canal to umbo.
Abstract The tympanic membrane (TM) has a key role in transmitting sounds to the inner ear, but a concise description of how the TM performs this function remains elusive. This paper probes TM operation by applying a free field click stimulus to the gerbil ear and exploring the consequent motions of the TM and umbo. Motions of the TM were measured both on radial tracks starting close to the umbo and on a grid distal and adjacent to the umbo. The experimental results confirmed the high fidelity of sound transmission from the ear canal to the umbo. A delay of 5-15 μs was seen in the onset of TM motion between poi...
Source: Hearing Research - January 9, 2017 Category: Audiology Authors: Milazzo M, Fallah E, Carapezza M, Kumar NS, Lei JH, Olson ES Tags: Hear Res Source Type: research

Culture media-based selection of endothelial cells, pericytes, and perivascular-resident macrophage-like melanocytes from the young mouse vestibular system.
Abstract The vestibular blood-labyrinth barrier (BLB) is comprised of perivascular-resident macrophage-like melanocytes (PVM/Ms) and pericytes (PCs), in addition to endothelial cells (ECs) and basement membrane (BM), and bears strong resemblance to the cochlear BLB in the stria vascularis. Over the past few decades, in vitro cell-based models have been widely used in blood-brain barrier (BBB) and blood-retina barrier (BRB) research, and have proved to be powerful tools for studying cell-cell interactions in their respective organs. Study of both the vestibular and strial BLB has been limited by the unavailability ...
Source: Hearing Research - January 9, 2017 Category: Audiology Authors: Zhang J, Chen S, Cai J, Hou Z, Wang X, Kachelmeier A, Shi X Tags: Hear Res Source Type: research

Degeneration of auditory nerve fibers in guinea pigs with severe sensorineural hearing loss.
In conclusion, the data strongly suggest that each surviving SGC possesses an axon. PMID: 28087418 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - January 9, 2017 Category: Audiology Authors: Kroon S, Ramekers D, Smeets EM, Hendriksen FG, Klis SF, Versnel H Tags: Hear Res Source Type: research

Cochlear synaptopathy in acquired sensorineural hearing loss: Manifestations and mechanisms.
Abstract Common causes of hearing loss in humans - exposure to loud noise or ototoxic drugs and aging - often damage sensory hair cells, reflected as elevated thresholds on the clinical audiogram. Recent studies in animal models suggest, however, that well before this overt hearing loss can be seen, a more insidious, but likely more common, process is taking place that permanently interrupts synaptic communication between sensory inner hair cells and subsets of cochlear nerve fibers. The silencing of affected neurons alters auditory information processing, whether accompanied by threshold elevations or not, and is...
Source: Hearing Research - January 9, 2017 Category: Audiology Authors: Liberman MC, Kujawa SG Tags: Hear Res Source Type: research

Engineering out the Noise.
Abstract The US Navy, through an Office of Naval Research (ONR) lead effort on Noise Induced Hearing Loss (NIHL), is investigating methods and techniques to mitigate hearing loss for the crews and warfighters. Hearing protection is a viable and increasingly popular method of reducing hearing exposure for many ship crewmembers; however, it has limitations on comfort and low frequency effectiveness. Furthermore, Personal Hearing Protection (PHP) is often used improperly. Proper vessel planning, programmatic changes and advances in noise control engineering can also have significant impacts by inherently reducing noi...
Source: Hearing Research - January 6, 2017 Category: Audiology Authors: Yankaskas K, Fischer R, Spence J, Komrower J Tags: Hear Res Source Type: research

Translational issues in cochlear synaptopathy.
Abstract Understanding the biology of the previously underappreciated sensitivity of cochlear synapses to noise insult, and its clinical consequences, is becoming a mission for a growing number of auditory researchers. In addition, several research groups have become interested in developing therapeutic approaches that can reverse synaptopathy and restore hearing function. One of the major challenges to realizing the potential of synaptopathy rodent models is that current clinical audiometric approaches cannot yet reveal the presence of this subtle cochlear pathology in humans. This has catalyzed efforts, both fro...
Source: Hearing Research - January 5, 2017 Category: Audiology Authors: Hickox AE, Larsen E, Heinz MG, Shinobu L, Whitton JP Tags: Hear Res Source Type: research

Genetic perturbations suggest a role of the resting potential in regulating the expression of the ion channels of the KCNA and HCN families in octopus cells of the ventral cochlear nucleus.
We report five new findings: First, the magnitude of gh and gKL varied over more than two-fold between wild type strains of mice. Second, average resting potentials are not different in different strains of mice even in the face of large differences in average gKL and gh. Third, IKL has two components, one being α-dendrotoxin (α-DTX)-sensitive and partially inactivating and the other being α-DTX-insensitive, tetraethylammonium (TEA)-sensitive, and non-inactivating. Fourth, the loss of Kv1.1 results in diminution of the α-DTX-sensitive IKL, and compensatory increased expression of an α-DTX-inse...
Source: Hearing Research - January 4, 2017 Category: Audiology Authors: Cao XJ, Oertel D Tags: Hear Res Source Type: research

Contralateral electrically-evoked suppression of transient evoked otoacoustic emissions in single-sided deaf patients.
PMID: 28057487 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - January 1, 2017 Category: Audiology Authors: Dziemba OC, Grafmans D, Merz S, Hocke T Tags: Hear Res Source Type: research

Simultaneously-evoked Auditory Potentials (SEAP): a new method for concurrent measurement of cortical and subcortical auditory-evoked activity.
Abstract Recent electrophysiological work has evinced a capacity for plasticity in subcortical auditory nuclei in human listeners. Similar plastic effects have been measured in cortically-generated auditory potentials but it is unclear how the two interact. Here we present Simultaneously-Evoked Auditory Potentials (SEAP), a method designed to concurrently elicit electrophysiological brain potentials from inferior colliculus, thalamus, and primary and secondary auditory cortices. Twenty-six normal-hearing adult subjects (mean 19.26 years, 9 male) were exposed to 2400 monaural (right-ear) presentations of a speciall...
Source: Hearing Research - December 29, 2016 Category: Audiology Authors: Slugocki C, Bosnyak D, Trainor LJ Tags: Hear Res Source Type: research

Cochlear hair cell regeneration after noise-induced hearing loss: Does regeneration follow development?
Abstract Noise-induced hearing loss (NIHL) affects a large number of military personnel and civilians. Regenerating inner-ear cochlear hair cells (HCs) is a promising strategy to restore hearing after NIHL. In this review, we first summarize recent transcriptome profile analysis of zebrafish lateral lines and chick utricles where spontaneous HC regeneration occurs after HC damage. We then discuss recent studies in other mammalian regenerative systems such as pancreas, heart and central nervous system. Both spontaneous and forced HC regeneration occurs in mammalian cochleae in vivo involving proliferation and direc...
Source: Hearing Research - December 25, 2016 Category: Audiology Authors: Zheng F, Zuo J Tags: Hear Res Source Type: research

Adenosine receptors regulate susceptibility to noise-induced neural injury in the mouse cochlea and hearing loss.
Abstract Our previous studies have shown that the stimulation of A1 adenosine receptors in the inner ear can mitigate the loss of sensory hair cells and hearing loss caused by exposure to traumatic noise. Here, we focus on the role of adenosine receptors (AR) in the development of noise-induced neural injury in the cochlea using A1AR and A2AAR null mice (A1AR(-/-) and A2AAR(-/-)). Wildtype (WT) and AR deficient mice were exposed to octave band noise (8-16 kHz, 100 dB SPL) for 2 hours to induce cochlear injury and hearing loss. Auditory thresholds and input/output functions were assessed using auditory brainstem re...
Source: Hearing Research - December 25, 2016 Category: Audiology Authors: Vlajkovic SM, Ambepitiya K, Barclay M, Boison D, Housley GD, Thorne PR Tags: Hear Res Source Type: research

Examining the short term effects of emotion under an Adaptation Level Theory Model of Tinnitus Perception.
CONCLUSIONS: The results indicate that the negative valence dimension of emotion is associated with increased tinnitus magnitude judgements and gender effects may also be present, but only when the emotional stimulus is in the auditory modality. Sounds with emotional associations may be used for sound therapy for tinnitus relief; it is of interest to determine whether the emotional component of sound treatments can play a role in reversing the negative responses discussed in this paper. PMID: 28027920 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - December 23, 2016 Category: Audiology Authors: Durai M, O'Keeffe MG, Searchfield GD Tags: Hear Res Source Type: research

Impaired auditory processing and altered structure of the endbulb of Held synapse in mice lacking the GluA3 subunit of AMPA receptors.
K, Rubio ME Abstract AMPA glutamate receptor complexes with fast kinetics conferred by subunits like GluA3 and GluA4 are essential for temporal precision of synaptic transmission. The specific role of GluA3 in auditory processing and experience related changes in the auditory brainstem remain unknown. We investigated the role of the GluA3 in auditory processing by using wild type (WT) and GluA3 knockout (GluA3-KO) mice. We recorded auditory brainstem responses (ABR) to assess auditory function and used electron microscopy to evaluate the ultrastructure of the auditory nerve synapse on bushy cells (AN-BC synapse). ...
Source: Hearing Research - December 19, 2016 Category: Audiology Authors: García-Hernández S, Abe M, Sakimura K, Rubio ME Tags: Hear Res Source Type: research