Auditory sequential accumulation of spectral information.
Abstract In many listening situations, information about the spectral content of a target sound may be distributed over time, and estimating the target spectrum requires efficient sequential processing. Listeners' ability to estimate the spectrum of a random-frequency, six-tone complex was investigated and the spectral content of the complex was revealed using a sequence of bursts. Whether each of the six tones was presented within each burst was determined at random according to a presentation probability. In separate conditions, the presentation probabilities (p) ranged from 0.2 to 1, the total number of bursts ...
Source: Hearing Research - October 11, 2017 Category: Audiology Authors: Shen Y Tags: Hear Res Source Type: research
An operating principle of the turtle utricle to detect wide dynamic range.
Abstract The utricle encodes both static information such as head orientation, and dynamic information such as vibrations. It is not well understood how the utricle can encode both static and dynamic information for a wide dynamic range (from 2 times the gravitational acceleration; from DC to > 1000 Hz vibrations). Using computational models of the hair cells in the turtle utricle, this study presents an explanation on how the turtle utricle encodes stimulations over such a wide dynamic range. Two hair bundles were modeled using the finite element method-one representing the striolar hair cell (C...
Source: Hearing Research - October 9, 2017 Category: Audiology Authors: Nam JH Tags: Hear Res Source Type: research
Corrigendum to "Place dependent stimulation rates improve pitch perception in cochlear implantees with single-sided deafness" [Hear. Res. 339 (2016) 94-103].
Corrigendum to "Place dependent stimulation rates improve pitch perception in cochlear implantees with single-sided deafness" [Hear. Res. 339 (2016) 94-103]. Hear Res. 2017 Oct;354:109 Authors: Rader T, Döge J, Adel Y, Weissgerber T, Baumann U PMID: 28958391 [PubMed - in process] (Source: Hearing Research)
Source: Hearing Research - September 30, 2017 Category: Audiology Authors: Rader T, Döge J, Adel Y, Weissgerber T, Baumann U Tags: Hear Res Source Type: research
Diversity of bilateral synaptic assemblies for binaural computation in midbrain single neurons.
This study examines the bilateral synaptic assemblies and binaural computation (or integration) in the central nucleus of the inferior colliculus (ICc) of the auditory midbrain, a key convergent center. Using in-vivo whole-cell patch-clamp, the excitatory and inhibitory postsynaptic potentials (EPSPs/IPSPs) of single ICc neurons to contralateral, ipsilateral and bilateral stimulation were recorded. According to the contralateral and ipsilateral EPSP/IPSP, 7 types of bilateral synaptic assemblies were identified. These include EPSP-EPSP (EE), E-IPSP (EI), E-no response (EO), II, IE, IO and complex-mode (CM) neurons. The CM ...
Source: Hearing Research - September 18, 2017 Category: Audiology Authors: He N, Kong L, Lin T, Wang S, Liu X, Qi J, Yan J Tags: Hear Res Source Type: research
Standard-interval size affects interval-discrimination thresholds for pure-tone melodic pitch intervals.
Abstract Our ability to discriminate between pitch intervals of different sizes is not only an important aspect of speech and music perception, but also a useful means of evaluating higher-level pitch perception. The current study examined how pitch-interval discrimination was affected by the size of the intervals being compared, and by musical training. Using an adaptive procedure, pitch-interval discrimination thresholds were measured for sequentially presented pure-tone intervals with standard intervals of 1 semitone (minor second), 6 semitones (the tri-tone), and 7 semitones (perfect fifth). Listeners were cla...
Source: Hearing Research - September 18, 2017 Category: Audiology Authors: McClaskey CM Tags: Hear Res Source Type: research
Language experience-dependent advantage in pitch representation in the auditory cortex is limited to favorable signal-to-noise ratios.
Abstract Long-term experience enhances neural representation of temporal attributes of pitch in the brainstem and auditory cortex in favorable listening conditions. Herein we examine whether cortical pitch mechanisms shaped by language experience are more resilient to degradation in background noise, and exhibit greater binaural release from masking (BRM). Cortical pitch responses (CPR) were recorded from Mandarin- and English-speaking natives using a Mandarin word exhibiting a high rising pitch (/yi(2)/). Stimuli were presented diotically in Quiet, and in noise at +5, and 0 dB SNR. CPRs were also record...
Source: Hearing Research - September 14, 2017 Category: Audiology Authors: Suresh CH, Krishnan A, Gandour JT Tags: Hear Res Source Type: research
Amplitude modulation rate dependent topographic organization of the auditory steady-state response in human auditory cortex.
Abstract Periodic modulations of an acoustic feature, such as amplitude over a certain frequency range, leads to phase locking of neural responses to the envelope of the modulation. Using electrophysiological methods this neural activity pattern, also called the auditory steady-state response (aSSR), is visible following frequency transformation of the evoked response as a clear spectral peak at the modulation frequency. Despite several studies employing the aSSR that show, for example, strongest responses for ∼40 Hz and an overall right-hemispheric dominance, it has not been investigated so far to what e...
Source: Hearing Research - September 11, 2017 Category: Audiology Authors: Weisz N, Lithari C Tags: Hear Res Source Type: research
Emotional recognition of dynamic facial expressions before and after cochlear implantation in adults with progressive deafness.
Abstract Visual processing has been extensively explored in deaf subjects in the context of verbal communication, through the assessment of speech reading and sign language abilities. However, little is known about visual emotional processing in adult progressive deafness, and after cochlear implantation. The goal of our study was thus to assess the influence of acquired post-lingual progressive deafness on the recognition of dynamic facial emotions that were selected to express canonical fear, happiness, sadness, and anger. A total of 23 adults with post-lingual deafness separated into two groups; those assessed ...
Source: Hearing Research - August 31, 2017 Category: Audiology Authors: Ambert-Dahan E, Giraud AL, Mecheri H, Sterkers O, Mosnier I, Samson S Tags: Hear Res Source Type: research
Effects of attention on the speech reception threshold and pupil response of people with impaired and normal hearing.
Abstract For people with hearing difficulties, following a conversation in a noisy environment requires substantial cognitive processing, which is often perceived as effortful. Recent studies with normal hearing (NH) listeners showed that the pupil dilation response, a measure of cognitive processing load, is affected by 'attention related' processes. How these processes affect the pupil dilation response for hearing impaired (HI) listeners remains unknown. Therefore, the current study investigated the effect of auditory attention on various pupil response parameters for 15 NH adults (median age 51 yrs.) and 15 ad...
Source: Hearing Research - August 30, 2017 Category: Audiology Authors: Koelewijn T, Versfeld NJ, Kramer SE Tags: Hear Res Source Type: research
The effect of blast overpressure on the mechanical properties of a chinchilla tympanic membrane.
Abstract The rupture of tympanic membrane (TM) has long been viewed as an indicator of blast injury, especially for hearing loss. However, little is known about damage to the TM caused by blast with pressure lower than the rupture threshold. In this paper, we present our study on the effect of blast overpressure on the static mechanical properties of TM. Chinchilla was used as the animal model and exposed to multiple blasts with pressures lower than the rupture threshold of the TM. Using a micro-fringe projection method, we observed the alteration of the static mechanical properties of post-blast chinchilla's TMs ...
Source: Hearing Research - August 18, 2017 Category: Audiology Authors: Liang J, Yokell ZA, Nakmaili DU, Gan RZ, Lu H Tags: Hear Res Source Type: research
Strain-specific differences in the development of neuronal excitability in the mouse ventral nucleus of the trapezoid body.
Abstract This investigation compared the development of neuronal excitability in the ventral nucleus of the trapezoid body (VNTB) between two strains of mice with differing progression rates for age-related hearing loss. In contrast to CBA/Ca (CBA) mice, the C57BL/6J (C57) strain are subject to hearing loss from a younger age and are more prone to damage from sound over-exposure. Higher firing rates in the medial olivocochlear system (MOC) are associated with protection from loud sounds and these cells are located in the VNTB. We postulated that reduced neuronal firing of the MOC in C57 mice could contribute to he...
Source: Hearing Research - August 18, 2017 Category: Audiology Authors: Sinclair JL, Barnes-Davies M, Kopp-Scheinpflug C, Forsythe ID Tags: Hear Res Source Type: research
No auditory experience, no tinnitus: Lessons from subjects with congenital- and acquired single-sided deafness.
This study enrolled 20 subjects with congenital SSD and 44 subjects with acquired SSD and examined the presence and characteristics of tinnitus in the groups. None of the 20 subjects with congenital SSD perceived tinnitus on the affected side, whereas 30 of 44 subjects with acquired SSD experienced tinnitus on the affected side. Additionally, there were significant positive correlations between tinnitus characteristics and the audiometric characteristics of the SSD. In accordance with the findings of the recent animal study, tinnitus was absent in subjects with congenital SSD, but relatively frequent in subjects with acqui...
Source: Hearing Research - August 15, 2017 Category: Audiology Authors: Lee SY, Nam DW, Koo JW, De Ridder D, Vanneste S, Song JJ Tags: Hear Res Source Type: research
Improved middle-ear soft-tissue visualization using synchrotron radiation phase-contrast imaging.
Abstract High resolution images are used as a basis for finite-element modeling of the middle-ear structures to study their biomechanical function. Commonly used imaging techniques such as micro-computed tomography (CT) and optical microscopy require extensive sample preparation, processing or staining using contrast agents to achieve sufficient soft-tissue contrast. We compare imaging of middle-ear structures in unstained, non-decalcified human temporal bones using conventional absorption-contrast micro-CT and using synchrotron radiation phase-contrast imaging (SR-PCI). Four cadaveric temporal bones were imaged u...
Source: Hearing Research - August 5, 2017 Category: Audiology Authors: Elfarnawany M, Rohani SA, Ghomashchi S, Allen DG, Zhu N, Agrawal SK, Ladak HM Tags: Hear Res Source Type: research
Speech reception with different bilateral directional processing schemes: Influence of binaural hearing, audiometric asymmetry, and acoustic scenario.
Abstract Hearing aid (HA) users can differ markedly in their benefit from directional processing (or beamforming) algorithms. The current study therefore investigated candidacy for different bilateral directional processing schemes. Groups of elderly listeners with symmetric (N = 20) or asymmetric (N = 19) hearing thresholds for frequencies below 2 kHz, a large spread in the binaural intelligibility level difference (BILD), and no difference in age, overall degree of hearing loss, or performance on a measure of selective attention took part. Aided speech reception was measured using virtua...
Source: Hearing Research - July 29, 2017 Category: Audiology Authors: Neher T, Wagener KC, Latzel M Tags: Hear Res Source Type: research
Otoliths - Accelerometer and seismometer; Implications in Vestibular Evoked Myogenic Potential (VEMP).
Abstract Vestibular otolithic organs are recognized as transducers of head acceleration and they function as such up to their corner frequency or undamped natural frequency. It is well recognized that these organs respond to frequencies above their corner frequency up to the 2-3 kHz range (Curthoys et al., 2016). A mechanics model for the transduction of these organs is developed that predicts the response below the undamped natural frequency as an accelerometer and above that frequency as a seismometer. The model is converted to a transfer function using hair cell bundle deflection. Measured threshold a...
Source: Hearing Research - July 27, 2017 Category: Audiology Authors: Grant W, Curthoys I Tags: Hear Res Source Type: research
Changes of metabolism and functional connectivity in late-onset deafness: Evidence from cerebral (18)F-FDG-PET.
Abstract Hearing loss is known to impact brain function. The aim of this study was to characterize cerebral metabolic Positron Emission Tomography (PET) changes in elderly patients fulfilling criteria for cochlear implant and investigate the impact of hearing loss on functional connectivity. Statistical Parametric Mapping-T-scores-maps comparisons of (18)F-FDG-PET of 27 elderly patients fulfilling criteria for cochlear implant for hearing loss (best-aided speech intelligibility lower or equal to 50%) and 27 matched healthy subjects (p
Source: Hearing Research - July 27, 2017 Category: Audiology Authors: Verger A, Roman S, Chaudat RM, Felician O, Ceccaldi M, Didic M, Guedj E Tags: Hear Res Source Type: research
Detecting temporal changes in acoustic scenes: The variable benefit of selective attention.
Abstract Four experiments investigated change detection in acoustic scenes consisting of a sum of five amplitude-modulated pure tones. As the tones were about 0.7 octave apart and were amplitude-modulated with different frequencies (in the range 2-32 Hz), they were perceived as separate streams. Listeners had to detect a change in the frequency (experiments 1 and 2) or the shape (experiments 3 and 4) of the modulation of one of the five tones, in the presence of an informative cue orienting selective attention either before the scene (pre-cue) or after it (post-cue). The changes left intensity unchanged and w...
Source: Hearing Research - July 27, 2017 Category: Audiology Authors: Demany L, Bayle Y, Puginier E, Semal C Tags: Hear Res Source Type: research
Declining and fluctuating prevalence values of hearing impairment in 18-year old Swedish men during three decades.
CONCLUSIONS: The most important observation was a decrease of HFHI 35-40 dB HL by 52% percent and of HFHI ≥45 dB HL by 71% between the years 1971 and 2004. The prevalence of HFHI 25-30 dB HL in young Swedish males fluctuated over a period of 33 years. Possible reasons for these trends and variations are discussed. PMID: 28759744 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - July 23, 2017 Category: Audiology Authors: Muhr P, Johnson AC, Rosenhall U Tags: Hear Res Source Type: research
Noise exposure alters long-term neural firing rates and synchrony in primary auditory and rostral belt cortices following bimodal stimulation.
Abstract We previously demonstrated that bimodal stimulation (spinal trigeminal nucleus [Sp5] paired with best frequency tone) altered neural tone-evoked and spontaneous firing rates (SFRs) in primary auditory cortex (A1) 15 min after pairing in guinea pigs with and without noise-induced tinnitus. Neural responses were enhanced (+10 ms) or suppressed (0 ms) based on the bimodal pairing interval. Here we investigated whether bimodal stimulation leads to long-term (up to 2 h) changes in tone-evoked and SFRs and neural synchrony (correlate of tinnitus) and if the long-term bimodal effects are alte...
Source: Hearing Research - July 13, 2017 Category: Audiology Authors: Takacs JD, Forrest TJ, Basura GJ Tags: Hear Res Source Type: research
Noise-induced cochlear synaptopathy in rhesus monkeys (Macaca mulatta).
Abstract Cochlear synaptopathy can result from various insults, including acoustic trauma, aging, ototoxicity, or chronic conductive hearing loss. For example, moderate noise exposure in mice can destroy up to ∼50% of synapses between auditory nerve fibers (ANFs) and inner hair cells (IHCs) without affecting outer hair cells (OHCs) or thresholds, because the synaptopathy occurs first in high-threshold ANFs. However, the fiber loss likely impairs temporal processing and hearing-in-noise, a classic complaint of those with sensorineural hearing loss. Non-human primates appear to be less vulnerable to noise-induce...
Source: Hearing Research - July 8, 2017 Category: Audiology Authors: Valero MD, Burton JA, Hauser SN, Hackett TA, Ramachandran R, Liberman MC Tags: Hear Res Source Type: research
Noise-induced hearing loss induces loudness intolerance in a rat Active Sound Avoidance Paradigm (ASAP).
Abstract Hyperacusis is a loudness hypersensitivity disorder in which moderate-intensity sounds are perceived as extremely loud, aversive and/or painful. To assess the aversive nature of sounds, we developed an Active Sound Avoidance Paradigm (ASAP) in which rats altered their place preference in a Light/Dark shuttle box in response to sound. When no sound (NS) was present, rats spent more than 95% of the time in the Dark Box versus the transparent Light Box. However, when a 60 or 90 dB SPL noise (2-20 kHz, 2-8 kHz, or 16-20 kHz bandwidth) was presented in the Dark Box, the rats'' preference fo...
Source: Hearing Research - July 8, 2017 Category: Audiology Authors: Manohar S, Spoth J, Radziwon K, Auerbach BD, Salvi R Tags: Hear Res Source Type: research
Medial geniculate neurons show diverse effects in response to electrical stimulation of prefrontal cortex.
Abstract Phantom perceptions have been proposed to arise due to dysfunctional sensory gating at the level of the thalamus. Recently, it has been suggested that tinnitus, a phantom perception of sound, may arise from altered cortico-limbic circuitry and its connection with the auditory thalamus, the medial geniculate nucleus (MGN). Indeed, some elements of this cortico-limbic circuitry, such as the prefrontal cortex (PFC), as well as elements of the auditory pathway, have been shown to be altered in humans with tinnitus. However, the functional connectivity between PFC and MGN has not yet been explored. We therefor...
Source: Hearing Research - July 8, 2017 Category: Audiology Authors: Barry KM, Robertson D, Mulders WHAM Tags: Hear Res Source Type: research
Synaptic distribution and plasticity in primary auditory cortex (A1) exhibits laminar and cell-specific changes in the deaf.
Abstract The processing sequence through primary auditory cortex (A1) is impaired by deafness as evidenced by reduced neuronal activation in A1 of cochlear-implanted deaf cats. Such a loss of neuronal excitation should be manifest as changes in excitatory synaptic number and/or size, for which the post-synaptic correlate is the dendritic spine. Therefore, the present study sought evidence for this functional disruption using Golgi-Cox/light microscopic techniques that examined spine-bearing neurons and their dendritic spine features across all laminae in A1 of early-deaf (ototoxic lesion 16 months) and hearing cat...
Source: Hearing Research - July 1, 2017 Category: Audiology Authors: Clemo HR, Lomber SG, Meredith MA Tags: Hear Res Source Type: research
Simultaneous masking between electric and acoustic stimulation in cochlear implant users with residual low-frequency hearing.
ueira W Abstract Ipsilateral electric-acoustic stimulation (EAS) is becoming increasingly important in cochlear implant (CI) treatment. Improvements in electrode designs and surgical techniques have contributed to improved hearing preservation during implantation. Consequently, CI implantation criteria have been expanded toward people with significant residual low-frequency hearing, who may benefit from the combined use of both the electric and acoustic stimulation in the same ear. However, only few studies have investigated the mutual interaction between electric and acoustic stimulation modalities. This work cha...
Source: Hearing Research - June 30, 2017 Category: Audiology Authors: Krüger B, Büchner A, Nogueira W Tags: Hear Res Source Type: research
Paraflocculus plays a role in salicylate-induced tinnitus.
Abstract Tinnitus impairs quality of life of about 1-2% of the whole population. In most severe situation, tinnitus may cause social isolation, depression and suicide. Drug treatments for tinnitus are generally ineffective, and the mechanisms of tinnitus are still undetermined. Accumulating evidence suggests that tinnitus is related to changes of widespread brain networks. Recent studies propose that paraflocculus (PFL), which is indirectly connected to various cortical regions, may be a gating zone of tinnitus. So we examined the electrophysiological changes and neurotransmitter alterations of the PFL in a rat mo...
Source: Hearing Research - June 29, 2017 Category: Audiology Authors: Du Y, Liu J, Jiang Q, Duan Q, Mao L, Ma F Tags: Hear Res Source Type: research
A comparative study of MED-EL FMT attachment to the long process of the incus in intact middle ears and its attachment to disarticulated stapes head.
Abstract The Vibrant Soundbridge(©) (VSB) active middle-ear implant provides an effective treatment for mild-to-severe sensorineural hearing loss in the case of normal middle ear anatomy and mixed hearing loss in middle ear malformation. The VSB floating mass transducer (FMT), with proper couplers, can be installed on various structures of the ossicular chain, e.g., the short and long process of the incus, the stapes head, and the stapes footplate. A long process (LP) coupler is most commonly used for FMT attachment to the long process of the incus with intact ossicular chain, while CliP and Bell couplers are...
Source: Hearing Research - June 23, 2017 Category: Audiology Authors: Chen T, Ren LJ, Yin DM, Li J, Yang L, Dai PD, Zhang TY Tags: Hear Res Source Type: research
Contralateral routing of signals disrupts monaural level and spectral cues to sound localisation on the horizontal plane.
CONCLUSIONS: The re-routing of sounds can restrict access to the monaural cues that provide a basis for determining sound location in the horizontal plane. Perhaps encouragingly, the results suggest that both monaural level and spectral cues may not be disrupted entirely by signal re-routing and that it may still be possible to reliably identify sounds originating on the hearing side. PMID: 28666702 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - June 21, 2017 Category: Audiology Authors: Pedley AJ, Kitterick PT Tags: Hear Res Source Type: research
Neural representations of concurrent sounds with overlapping spectra in rat inferior colliculus: Comparisons between temporal-fine structure and envelope.
In this study, we investigated the neural representation of two uncorrelated narrowband noises that shared the identical spectrum in the rat inferior colliculus (IC) using frequency-following-response (FFR) recordings, when the ITD for each noise stimulus was manipulated. The results of this study showed that recorded FFRs exhibited two distinctive components: the fast-varying temporal fine structure (TFS) component (FFRTFS) and the slow-varying envelope component (FFRENV). When a single narrowband noise was presented alone, the FFRTFS, but not the FFRENV, was sensitive to ITDs. When two narrowband noises were presented si...
Source: Hearing Research - June 17, 2017 Category: Audiology Authors: Luo L, Wang Q, Li L Tags: Hear Res Source Type: research
Characterization of the superior olivary complex of Canis lupus domesticus.
Kulesza RJ Abstract The superior olivary complex (SOC) is a collection of brainstem auditory nuclei which play essential roles in the localization of sound sources, temporal coding of vocalizations and descending modulation of the cochlea. Notwithstanding, the SOC nuclei vary considerably between species in accordance with the auditory needs of the animal. The canine SOC was subjected to anatomical and physiological examination nearly 50 years ago and was then virtually forgotten. Herein, we aimed to characterize the nuclei of the canine SOC using quantitative morphometrics, estimation of neuronal number, histoch...
Source: Hearing Research - June 15, 2017 Category: Audiology Authors: Fech T, Calderón-Garcidueñas L, Kulesza RJ Tags: Hear Res Source Type: research
Effect of stimulus level on the temporal response properties of the auditory nerve in cochlear implants.
Abstract Electrically evoked compound action potentials (ECAPs) have been used to examine temporal response patterns of the auditory nerve in cochlear implant (CI) recipients. ECAP responses to individual pulses in a pulse train vary across stimulation rates for individual CI users. For very slow rates, auditory neurons have ample time to discharge, recover, and respond to each pulse in the train. As the pulse rate increases, an alternating ECAP-amplitude pattern occurs. As the stimulation rate increases further, the alternating pattern eventually ceases and the overall ECAP amplitudes are diminished, yielding a r...
Source: Hearing Research - June 13, 2017 Category: Audiology Authors: Hughes ML, Laurello SA Tags: Hear Res Source Type: research
Altered attentional filters in subjects with graded levels of sensorineural hearing loss.
Abstract Near-threshold tones (targets) in noise that are preceded by cues of the same frequency or occur with a high probability are detected better than tones of other frequencies that may occur with a lower probability (probes); the better detection of targets than probes defines the attentional filter. We measured attentional filters using a cued probe-signal procedure with a two-interval forced-choice (2IFC) method in normal-hearing subjects (N = 15) and subjects with sensorineural hearing loss (SNHL; N = 14) with a range of hearing levels. Attentional filters were altered in SNHL subjects...
Source: Hearing Research - June 10, 2017 Category: Audiology Authors: Bester CW, Robertson D, Taljaard D, Hammond G Tags: Hear Res Source Type: research
Sheep as a large animal ear model: Middle-ear ossicular velocities and intracochlear sound pressure.
This study investigated the middle-ear ossicular velocities and intracochlear sound pressure (ICSP) in sheep temporal bones, with the aim of characterizing the sheep as an experimental model for implantable hearing devices. Measurements were made on fresh sheep temporal bones. Velocity responses of the middle ear ossicles at the umbo, long process of the incus and stapes footplate were measured in the frequency range of 0.25-8 kHz using a laser Doppler vibrometer system. Results were normalized by the corresponding sound pressure level in the external ear canal (PEC). Sequentially, ICSPs at the scala vestibuli and tym...
Source: Hearing Research - June 7, 2017 Category: Audiology Authors: Péus D, Dobrev I, Prochazka L, Thoele K, Dalbert A, Boss A, Newcomb N, Probst R, Röösli C, Sim JH, Huber A, Pfiffner F Tags: Hear Res Source Type: research
Editorial: Auditory injury - A military perspective.
PMID: 28526261 [PubMed - in process] (Source: Hearing Research)
Source: Hearing Research - May 21, 2017 Category: Audiology Authors: Yankaskas K, Hammill T, Packer M, Zuo J Tags: Hear Res Source Type: research
Peripheral hearing loss reduces the ability of children to direct selective attention during multi-talker listening.
We examined the ability of hearing-impaired children to direct auditory attention to a voice of interest (based on the talker's spatial location or gender) in the presence of a common form of background noise: the voices of competing talkers (i.e. during multi-talker, or "Cocktail Party" listening). We measured brain activity using electro-encephalography (EEG) when children prepared to direct attention to the spatial location or gender of an upcoming target talker who spoke in a mixture of three talkers. Compared to normally-hearing children, hearing-impaired children showed significantly less evidence of prepar...
Source: Hearing Research - May 10, 2017 Category: Audiology Authors: Holmes E, Kitterick PT, Summerfield AQ Tags: Hear Res Source Type: research
Amino acid and acetylcholine chemistry in the central auditory system of young, middle-aged and old rats.
In this study, we used quantitative microchemical methods to map concentrations of amino acids, including the major neurotransmitters of the brain, in all the major central auditory structures of young (6 months), middle-aged (22 months), and old (33 months old) Fischer 344 x Brown Norway rats. In addition, some amino acid measurements were made for vestibular nuclei, and activities of choline acetyltransferase, the enzyme for acetylcholine synthesis, were mapped in the superior olive and auditory cortex. In old, as compared to young, rats, glutamate concentrations were lower throughout central auditory regions. Aspartate ...
Source: Hearing Research - May 4, 2017 Category: Audiology Authors: Godfrey DA, Chen K, O'Toole TR, Mustapha AIAA Tags: Hear Res Source Type: research
Response to letter: Psychometric properties of the Tinnitus Functional Index (TFI): Assessment in a UK research volunteer population.
PMID: 28495019 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - May 4, 2017 Category: Audiology Authors: Fackrell K, Hall DA, Barry JG, Hoare DJ Tags: Hear Res Source Type: research
Effect of efferent activation on binaural frequency selectivity.
Abstract Binaural notched-noise experiments indicate a reduced frequency selectivity of the binaural system compared to monaural processing. The present study investigates how auditory efferent activation (via the medial olivocochlear system) affects binaural frequency selectivity in normal-hearing listeners. Thresholds were measured for a 1-kHz signal embedded in a diotic notched-noise masker for various notch widths. The signal was either presented in phase (diotic) or in antiphase (dichotic), gated with the noise. Stimulus duration was 25 ms, in order to avoid efferent activation due to the masker or the s...
Source: Hearing Research - May 2, 2017 Category: Audiology Authors: Verhey JL, Kordus M, Drga V, Yasin I Tags: Hear Res Source Type: research
Chronic tinnitus and unipolar brush cell alterations in the cerebellum and dorsal cochlear nucleus.
Abstract Animal model research has shown that the central features of tinnitus, the perception of sound without an acoustic correlate, include elevated spontaneous and stimulus-driven activity, enhanced burst-mode firing, decreased variance of inter-spike intervals, and distortion of tonotopic frequency representation. Less well documented are cell-specific correlates of tinnitus. Unipolar brush cell (UBC) alterations in animals with psychophysical evidence of tinnitus has recently been reported. UBCs are glutamatergic interneurons that appear to function as local-circuit signal amplifiers. UBCs are abundant in th...
Source: Hearing Research - May 2, 2017 Category: Audiology Authors: Brozoski T, Brozoski D, Wisner K, Bauer C Tags: Hear Res Source Type: research
Salicylate-induced hyperacusis in rats: Dose- and frequency-dependent effects.
Abstract The use of auditory reaction time is a reliable measure of loudness perception in both animals and humans with reaction times (RT) decreasing with increasing stimulus intensity. Since abnormal loudness perception is a common feature of hyperacusis, a potentially debilitating auditory disorder in which moderate-intensity sounds are perceived as uncomfortable or painfully loud, we used RT measures to assess rats for salicylate-induced hyperacusis. A previous study using an operant conditioning RT procedure found that high-dose sodium salicylate (SS) induced hyperacusis-like behavior, i.e., faster than norma...
Source: Hearing Research - April 27, 2017 Category: Audiology Authors: Radziwon K, Holfoth D, Lindner J, Kaier-Green Z, Bowler R, Urban M, Salvi R Tags: Hear Res Source Type: research
Effects of noise-induced hearing loss on parvalbumin and perineuronal net expression in the mouse primary auditory cortex.
Abstract Noise induced hearing loss is associated with increased excitability in the central auditory system but the cellular correlates of such changes remain to be characterized. Here we tested the hypothesis that noise-induced hearing loss causes deterioration of perineuronal nets (PNNs) in the auditory cortex of mice. PNNs are specialized extracellular matrix components that commonly enwrap cortical parvalbumin (PV) containing GABAergic interneurons. Compared to somatosensory and visual cortex, relatively less is known about PV/PNN expression patterns in the primary auditory cortex (A1). Whether changes to cor...
Source: Hearing Research - April 27, 2017 Category: Audiology Authors: Nguyen A, Khaleel HM, Razak KA Tags: Hear Res Source Type: research
Streptococcus pneumoniae-induced ototoxicity in organ of Corti explant cultures.
Abstract Hearing loss remains the most common long-term complication of pneumococcal meningitis (PM) reported in up to 30% of survivors. Streptococcus pneumoniae have been shown to possess different ototoxic properties. Here we present a novel ex vivo experimental setup to examine in detail the pattern of hair cell loss upon exposure to different S. pneumoniae strains, therefore recapitulating pathogen derived aspects of PM-induced hearing loss. Our results show a higher susceptibility towards S. pneumoniae-induced cochlear damage for outer hair cells (OHC) compared to inner hair cells (IHC), which ...
Source: Hearing Research - April 25, 2017 Category: Audiology Authors: Perny M, Solyga M, Grandgirard D, Roccio M, Leib SL, Senn P Tags: Hear Res Source Type: research
Early cortical metabolic rearrangement related to clinical data in idiopathic sudden sensorineural hearing loss.
Abstract Results in studies concerning cortical changes in idiopathic sudden sensorineural hearing loss (ISSNHL) are not homogeneous, in particular due to the different neuroimaging techniques implemented and the diverse stages of ISSNHL studied. Considering the recent advances in state-of-the-art positron emission tomography (PET) cameras, the aim of this study was to gain more insight into the neuroanatomical differences associated with the earliest stages of unilateral ISSNHL and clinical-perceptual performance changes. After an audiological examination including the mean auditory threshold (mean AT), mean spee...
Source: Hearing Research - April 25, 2017 Category: Audiology Authors: Micarelli A, Chiaravalloti A, Viziano A, Danieli R, Schillaci O, Alessandrini M Tags: Hear Res Source Type: research
Neural indices of phonemic discrimination and sentence-level speech intelligibility in quiet and noise: A P3 study.
This study examined how speech babble noise differentially affected the auditory P3 responses and the associated neural oscillatory activities for consonant and vowel discrimination in relation to segmental- and sentence-level speech perception in noise. The data were collected from 16 normal-hearing participants in a double-oddball paradigm that contained a consonant (/ba/ to /da/) and vowel (/ba/ to /bu/) change in quiet and noise (speech-babble background at a -3 dB signal-to-noise ratio) conditions. Time-frequency analysis was applied to obtain inter-trial phase coherence (ITPC) and event-related spectral per...
Source: Hearing Research - April 18, 2017 Category: Audiology Authors: Koerner TK, Zhang Y, Nelson PB, Wang B, Zou H Tags: Hear Res Source Type: research
Delayed changes in auditory status in cochlear implant users with preserved acoustic hearing.
Abstract This retrospective review explores delayed-onset hearing loss in 85 individuals receiving cochlear implants designed to preserve acoustic hearing at the University of Iowa Hospitals and Clinics between 2001 and 2015. Repeated measures of unaided behavioral audiometric thresholds, electrode impedance, and electrically evoked compound action potential (ECAP) amplitude growth functions were used to characterize longitudinal changes in auditory status. Participants were grouped into two primary categories according to changes in unaided behavioral thresholds: (1) stable hearing or symmetrical hearing loss and...
Source: Hearing Research - April 12, 2017 Category: Audiology Authors: Scheperle RA, Tejani VD, Omtvedt JK, Brown CJ, Abbas PJ, Hansen MR, Gantz BJ, Oleson JJ, Ozanne MV Tags: Hear Res Source Type: research
A non-toxic dose of cobalt chloride blocks hair cells of the zebrafish lateral line.
Abstract Experiments on the flow-sensitive lateral line system of fishes have provided important insights into the function and sensory transduction of vertebrate hair cells. A common experimental approach has been to pharmacologically block lateral line hair cells and measure how behavior changes. Cobalt chloride (CoCl2) blocks the lateral line by inhibiting calcium movement through the membrane channels of hair cells, but high concentrations can be toxic, making it unclear whether changes in behavior are due to a blocked lateral line or poor health. Here, we identify a non-toxic treatment of cobalt that complete...
Source: Hearing Research - April 12, 2017 Category: Audiology Authors: Stewart WJ, Johansen JL, Liao JC Tags: Hear Res Source Type: research
On the role of ephrinA2 in auditory function.
Abstract Recent findings suggest that the manipulation of the EphA/ephrinA system can improve hearing threshold sensitivity in the auditory system (Yates et al., 2014). These results appear to open-up the possibility that pharmacological manipulation of this system could lead to the development of treatments to cure some types of hearing loss. As a first step towards this goal, we have performed a further series of auditory brainstem evoked potential recordings on ephrinA2 homozygous knockout mice and their wildtype littermates in order to replicate the previously reported findings. However, we found that eph...
Source: Hearing Research - April 5, 2017 Category: Audiology Authors: Ingham NJ, Steel KP, Drescher U Tags: Hear Res Source Type: research
Reply to "Critical examination of the article: Impulse noise injury prediction based on the cochlear energy".
Reply to "Critical examination of the article: Impulse noise injury prediction based on the cochlear energy". Hear Res. 2017 Mar 30;: Authors: Zagadou B, Chan P, Ho K, Shelley D PMID: 28390736 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - March 30, 2017 Category: Audiology Authors: Zagadou B, Chan P, Ho K, Shelley D Tags: Hear Res Source Type: research
The intelligibility of speech in a harmonic masker varying in fundamental frequency contour, broadband temporal envelope, and spatial location.
he ML Abstract Differences in fundamental frequency (F0), modulations in the masker envelope, and differences in spatial location between a speech target and a masker can improve speech intelligibility in cocktail-party situations. These cues have been thoroughly investigated independently and associated with unmasking mechanisms: F0 segregation, temporal dip listening and spatial unmasking, respectively. Two experiments were conducted to examine whether F0 segregation interacts with spatial unmasking (experiment 1) or temporal modulations in the masker envelope (experiment 2) by measuring speech reception thresho...
Source: Hearing Research - March 29, 2017 Category: Audiology Authors: Leclère T, Lavandier M, Deroche ML Tags: Hear Res Source Type: research
Modulation of auditory percepts by transcutaneous electrical stimulation.
Abstract Transcutaneous, electrical stimulation with electrodes placed on the mastoid processes represents a specific way to elicit vestibular reflexes in humans without active or passive subject movements, for which the term galvanic vestibular stimulation was coined. It has been suggested that galvanic vestibular stimulation mainly affects the vestibular periphery, but whether vestibular hair cells, vestibular afferents, or a combination of both are excited, is still a matter of debate. Galvanic vestibular stimulation has been in use since the late 18(th) century, but despite the long-known and well-documented e...
Source: Hearing Research - March 17, 2017 Category: Audiology Authors: Ueberfuhr MA, Braun A, Wiegrebe L, Grothe B, Drexl M Tags: Hear Res Source Type: research
Comparison of perceptual properties of auditory streaming between spectral and amplitude modulation domains.
Abstract The two-tone sequence (ABA_), which comprises two different sounds (A and B) and a silent gap, has been used to investigate how the auditory system organizes sequential sounds depending on various stimulus conditions or brain states. Auditory streaming can be evoked by differences not only in the tone frequency ("spectral cue": ΔFTONE, TONE condition) but also in the amplitude modulation rate ("AM cue": ΔFAM, AM condition). The aim of the present study was to explore the relationship between the perceptual properties of auditory streaming for the TONE and AM conditions. A s...
Source: Hearing Research - March 17, 2017 Category: Audiology Authors: Yamagishi S, Otsuka S, Furukawa S, Kashino M Tags: Hear Res Source Type: research