Abrupt phase changes coupled with waning in amplitude of neural oscillation lead to phase-locking in the auditory evoked responses
Hear Res. 2023 Dec 12;442:108936. doi: 10.1016/j.heares.2023.108936. Online ahead of print.ABSTRACTNeural oscillations on the human auditory cortex measured with the magnetoencephalography were band-pass filtered between 3 and 16 Hz and then divided into instantaneous phases and amplitudes by the Hilbert transformation. Spontaneously, the amplitudes fluctuated, i.e. waxed and waned; The phases rotated at around 6 Hz most of the time, but abruptly accelerated or decelerated when the amplitudes waned close to zero. After auditory stimuli, the amplitudes and the phases were coupled in the same way as spontaneously. Amounts an...
Source: Hearing Research - December 16, 2023 Category: Audiology Authors: Takashi Hamada Source Type: research
Combinatorial Atoh1, Gfi1, Pou4f3, and Six1 gene transfer induces hair cell regeneration in the flat epithelium of mature guinea pigs
Hear Res. 2023 Nov 17;441:108916. doi: 10.1016/j.heares.2023.108916. Online ahead of print.ABSTRACTFlat epithelium (FE) is a condition characterized by the loss of both hair cells (HCs) and supporting cells and the transformation of the organ of Corti into a simple flat or cuboidal epithelium, which can occur after severe cochlear insults. The transcription factors Gfi1, Atoh1, Pou4f3, and Six1 (GAPS) play key roles in HC differentiation and survival in normal ears. Previous work using a single transcription factor, Atoh1, to induce HC regeneration in mature ears in vivo usually produced very few cells and failed to produc...
Source: Hearing Research - December 16, 2023 Category: Audiology Authors: Yujie Liu Lin Yang Sunita Singh Lisa A Beyer Diane M Prieskorn Donald L Swiderski Andrew K Groves Yehoash Raphael Source Type: research
Abrupt phase changes coupled with waning in amplitude of neural oscillation lead to phase-locking in the auditory evoked responses
Hear Res. 2023 Dec 12;442:108936. doi: 10.1016/j.heares.2023.108936. Online ahead of print.ABSTRACTNeural oscillations on the human auditory cortex measured with the magnetoencephalography were band-pass filtered between 3 and 16 Hz and then divided into instantaneous phases and amplitudes by the Hilbert transformation. Spontaneously, the amplitudes fluctuated, i.e. waxed and waned; The phases rotated at around 6 Hz most of the time, but abruptly accelerated or decelerated when the amplitudes waned close to zero. After auditory stimuli, the amplitudes and the phases were coupled in the same way as spontaneously. Amounts an...
Source: Hearing Research - December 16, 2023 Category: Audiology Authors: Takashi Hamada Source Type: research
Measurements of bone-conducted sound in the chinchilla external ear
Hear Res. 2023 Dec 9;441:108926. doi: 10.1016/j.heares.2023.108926. Online ahead of print.ABSTRACTWe measure bone-conduction (BC) induced skull velocity, sound pressure at the tympanic membrane (TM) and inner-ear compound-action potentials (CAP) before and after manipulating the ear canal, ossicles, and the jaw to investigate the generation of BC induced ear-canal sound pressures and their contribution to inner-ear BC response in the ears of chinchillas. These measurements suggest that in chinchilla: i.) Vibrations of the bony ear canal walls contribute significantly to BC-induced ear canal sound pressures, as occluding th...
Source: Hearing Research - December 14, 2023 Category: Audiology Authors: Peter Bowers Michael E Ravicz John J Rosowski Source Type: research
Normal behavioral discrimination of envelope statistics in budgerigars with kainate-induced cochlear synaptopathy
Hear Res. 2023 Dec 9;441:108927. doi: 10.1016/j.heares.2023.108927. Online ahead of print.ABSTRACTCochlear synaptopathy is a common pathology in humans associated with aging and potentially sound overexposure. Synaptopathy is widely expected to cause "hidden hearing loss," including difficulty perceiving speech in noise, but support for this hypothesis is controversial. Here in budgerigars (Melopsittacus undulatus), we evaluated the impact of long-term cochlear synaptopathy on behavioral discrimination of Gaussian noise (GN) and low-noise noise (LNN) signals processed to have a flatter envelope. Stimuli had center frequenc...
Source: Hearing Research - December 14, 2023 Category: Audiology Authors: Kenneth S Henry Anna A Guo Kristina S Abrams Source Type: research
Measurements of bone-conducted sound in the chinchilla external ear
Hear Res. 2023 Dec 9;441:108926. doi: 10.1016/j.heares.2023.108926. Online ahead of print.ABSTRACTWe measure bone-conduction (BC) induced skull velocity, sound pressure at the tympanic membrane (TM) and inner-ear compound-action potentials (CAP) before and after manipulating the ear canal, ossicles, and the jaw to investigate the generation of BC induced ear-canal sound pressures and their contribution to inner-ear BC response in the ears of chinchillas. These measurements suggest that in chinchilla: i.) Vibrations of the bony ear canal walls contribute significantly to BC-induced ear canal sound pressures, as occluding th...
Source: Hearing Research - December 14, 2023 Category: Audiology Authors: Peter Bowers Michael E Ravicz John J Rosowski Source Type: research
Normal behavioral discrimination of envelope statistics in budgerigars with kainate-induced cochlear synaptopathy
Hear Res. 2023 Dec 9;441:108927. doi: 10.1016/j.heares.2023.108927. Online ahead of print.ABSTRACTCochlear synaptopathy is a common pathology in humans associated with aging and potentially sound overexposure. Synaptopathy is widely expected to cause "hidden hearing loss," including difficulty perceiving speech in noise, but support for this hypothesis is controversial. Here in budgerigars (Melopsittacus undulatus), we evaluated the impact of long-term cochlear synaptopathy on behavioral discrimination of Gaussian noise (GN) and low-noise noise (LNN) signals processed to have a flatter envelope. Stimuli had center frequenc...
Source: Hearing Research - December 14, 2023 Category: Audiology Authors: Kenneth S Henry Anna A Guo Kristina S Abrams Source Type: research
Measurements of bone-conducted sound in the chinchilla external ear
Hear Res. 2023 Dec 9;441:108926. doi: 10.1016/j.heares.2023.108926. Online ahead of print.ABSTRACTWe measure bone-conduction (BC) induced skull velocity, sound pressure at the tympanic membrane (TM) and inner-ear compound-action potentials (CAP) before and after manipulating the ear canal, ossicles, and the jaw to investigate the generation of BC induced ear-canal sound pressures and their contribution to inner-ear BC response in the ears of chinchillas. These measurements suggest that in chinchilla: i.) Vibrations of the bony ear canal walls contribute significantly to BC-induced ear canal sound pressures, as occluding th...
Source: Hearing Research - December 14, 2023 Category: Audiology Authors: Peter Bowers Michael E Ravicz John J Rosowski Source Type: research
Normal behavioral discrimination of envelope statistics in budgerigars with kainate-induced cochlear synaptopathy
Hear Res. 2023 Dec 9;441:108927. doi: 10.1016/j.heares.2023.108927. Online ahead of print.ABSTRACTCochlear synaptopathy is a common pathology in humans associated with aging and potentially sound overexposure. Synaptopathy is widely expected to cause "hidden hearing loss," including difficulty perceiving speech in noise, but support for this hypothesis is controversial. Here in budgerigars (Melopsittacus undulatus), we evaluated the impact of long-term cochlear synaptopathy on behavioral discrimination of Gaussian noise (GN) and low-noise noise (LNN) signals processed to have a flatter envelope. Stimuli had center frequenc...
Source: Hearing Research - December 14, 2023 Category: Audiology Authors: Kenneth S Henry Anna A Guo Kristina S Abrams Source Type: research
Making sense of music: Insights from neurophysiology and connectivity analyses in naturalistic listening conditions
Hear Res. 2023 Dec 9;441:108923. doi: 10.1016/j.heares.2023.108923. Online ahead of print.ABSTRACTAccording to the latest frameworks, auditory perception and memory involve the constant prediction of future sound events by the brain, based on the continuous extraction of feature regularities from the environment. The neural hierarchical mechanisms for predictive processes in perception and memory for sounds are typically studied in relation to simple acoustic features in isolated sounds or sound patterns inserted in highly certain contexts. Such studies have identified reliable prediction formation and error signals, e.g.,...
Source: Hearing Research - December 13, 2023 Category: Audiology Authors: Elvira Brattico Marianna Delussi Source Type: research
Making sense of music: Insights from neurophysiology and connectivity analyses in naturalistic listening conditions
Hear Res. 2023 Dec 9;441:108923. doi: 10.1016/j.heares.2023.108923. Online ahead of print.ABSTRACTAccording to the latest frameworks, auditory perception and memory involve the constant prediction of future sound events by the brain, based on the continuous extraction of feature regularities from the environment. The neural hierarchical mechanisms for predictive processes in perception and memory for sounds are typically studied in relation to simple acoustic features in isolated sounds or sound patterns inserted in highly certain contexts. Such studies have identified reliable prediction formation and error signals, e.g.,...
Source: Hearing Research - December 13, 2023 Category: Audiology Authors: Elvira Brattico Marianna Delussi Source Type: research
Comprehensive behavioral and physiologic assessment of peripheral and central auditory function in individuals with mild traumatic brain injury
Hear Res. 2023 Dec 5;441:108928. doi: 10.1016/j.heares.2023.108928. Online ahead of print.ABSTRACTAuditory complaints are frequently reported by individuals with mild traumatic brain injury (mTBI) yet remain difficult to detect in the absence of clinically significant hearing loss. This highlights a growing need to identify sensitive indices of auditory-related mTBI pathophysiology beyond pure-tone thresholds for improved hearing healthcare diagnosis and treatment. Given the heterogeneity of mTBI etiology and the diverse peripheral and central processes required for normal auditory function, the present study sought to det...
Source: Hearing Research - December 12, 2023 Category: Audiology Authors: Amy N Stahl Jordan M Racca Cailey I Kerley Adam Anderson Bennett Landman Linda J Hood Ren é H Gifford Tonia S Rex Source Type: research
Head-related transfer functions of rabbits within the front horizontal plane
Hear Res. 2023 Dec 2;441:108924. doi: 10.1016/j.heares.2023.108924. Online ahead of print.ABSTRACTThe head-related transfer function (HRTF) describes the direction-dependent acoustic filtering by the head that occurs between a source signal in free-field space and the signal at the tympanic membrane. HRTFs contain information on sound source location via interaural differences of their magnitude or phase spectra and via the shapes of their magnitude spectra. The present study characterized HRTFs for source locations in the front horizontal plane for nine rabbits, which are a species commonly used in studies of the central ...
Source: Hearing Research - December 7, 2023 Category: Audiology Authors: Mitchell L Day Source Type: research
Factors that can affect divided speech intelligibility
Hear Res. 2023 Dec 2;441:108917. doi: 10.1016/j.heares.2023.108917. Online ahead of print.ABSTRACTPrevious studies have shown that in challenging listening situations, people find it hard to equally divide their attention between two simultaneous talkers and tend to favor one talker over the other. The aim here was to investigate whether talker onset/offset, sex and location determine the favored talker. Fifteen people with normal hearing were asked to recognize as many words as possible from two sentences uttered by two talkers located at 45° and +45° azimuth, respectively. The sentences were from the same corpus, were ...
Source: Hearing Research - December 7, 2023 Category: Audiology Authors: Milagros J Fumero Miriam I Marrufo-P érez Almudena Eustaquio-Mart ín Enrique A Lopez-Poveda Source Type: research
Head-related transfer functions of rabbits within the front horizontal plane
Hear Res. 2023 Dec 2;441:108924. doi: 10.1016/j.heares.2023.108924. Online ahead of print.ABSTRACTThe head-related transfer function (HRTF) describes the direction-dependent acoustic filtering by the head that occurs between a source signal in free-field space and the signal at the tympanic membrane. HRTFs contain information on sound source location via interaural differences of their magnitude or phase spectra and via the shapes of their magnitude spectra. The present study characterized HRTFs for source locations in the front horizontal plane for nine rabbits, which are a species commonly used in studies of the central ...
Source: Hearing Research - December 7, 2023 Category: Audiology Authors: Mitchell L Day Source Type: research
