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HEI-OC1 Cells as a Model for Investigating Prestin Function.
Abstract The House Ear Institute-Organ of Corti 1 (HEI-OC1) is a mouse auditory cell line that endogenously express, among other several markers of cochlear hair cells, the motor protein prestin (SLC26A5). Since its discovery fifteen years ago, and because of the difficulties associated with working with outer hair cells, prestin studies have been performed mostly by expressing it exogenously in non-specific systems such as HEK293 and TSA201, embryonic kidney cells from human origin, or Chinese Hamster Ovary (CHO) cells. Here, we report flow cytometry and confocal laser scanning microscopy studies on the pattern o...
Source: Hearing Research - February 5, 2016 Category: Audiology Authors: Park C, Thein P, Kalinec G, Kalinec F Tags: Hear Res Source Type: research

A next-generation sequencing gene panel (MiamiOtoGenes) for comprehensive analysis of deafness genes.
Abstract Extreme genetic heterogeneity along with remarkable variation in the distribution of causative variants across in different ethnicities makes single gene testing inefficient for hearing loss. We developed a custom capture/next-generation sequencing gene panel of 146 known deafness genes with a total target size of approximately 1 MB. The genes were identified by searching databases including Hereditary Hearing Loss Homepage, the Human Genome Mutation Database (HGMD), Online Mendelian Inheritance in Man (OMIM) and most recent peer-reviewed publications related to the genetics of deafness. The design c...
Source: Hearing Research - February 2, 2016 Category: Audiology Authors: Tekin D, Yan D, Bademci G, Feng Y, Guo S, Foster J, Blanton S, Tekin M, Liu X Tags: Hear Res Source Type: research

Indication of Direct Acoustical Cochlea Stimulation in Comparison to Cochlear Implants.
r H Abstract The new implantable hearing system Codacs™ was designed to close the treatment gap between active middle ear implants and cochlear implants in cases of severe-to-profound mixed hearing loss. The Codacs™ actuator is attached to conventional stapes prosthesis during the implantation and thereby provides acoustical stimulation through a stapedotomy to the cochlea. Cochlear implants (CIs) on the other hand are an established treatment option for profoundly deaf patients including mixed hearing losses that are possible candidates for the Codacs™. In this retrospective study, we compared t...
Source: Hearing Research - January 30, 2016 Category: Audiology Authors: Kludt E, Büchner A, Schwab B, Lenarz T, Maier H Tags: Hear Res Source Type: research

Channeling Your Inner Ear Potassium: K(+) Channels in Vestibular Hair Cells.
Abstract During development of vestibular hair cells, K(+) conductances are acquired in a specific pattern. Functionally mature vestibular hair cells express different complements of K(+) channels which uniquely shape the hair cell receptor potential and filtering properties. In amniote species, type I hair cells (HCI) have a large input conductance due to a ubiquitous low-voltage-activated K(+) current that activates with slow sigmoidal kinetics at voltages negative to the membrane resting potential. In contrast type II hair cells (HCII) from mammalian and non-mammalian species have voltage-dependent outward K(+)...
Source: Hearing Research - January 30, 2016 Category: Audiology Authors: Meredith FL, Rennie KJ Tags: Hear Res Source Type: research

Bilateral cochlear implants in children: Effects of auditory experience and deprivation on auditory perception.
Abstract Spatial hearing skills are essential for children as they grow, learn and play. They provide critical cues for determining the locations of sources in the environment, and enable segregation of important sources, such as speech, from background maskers or interferers. Spatial hearing depends on availability of monaural cues and binaural cues. The latter result from integration of inputs arriving at the two ears from sounds that vary in location. The binaural system has exquisite mechanisms for capturing differences between the ears in both time of arrival and intensity. The major cues that are thus referr...
Source: Hearing Research - January 29, 2016 Category: Audiology Authors: Litovsky RY, Gordon K Tags: Hear Res Source Type: research

Decoding four different sound-categories in the auditory cortex using functional near-infrared spectroscopy.
This study investigated whether activations in the auditory cortex caused by different sounds can be distinguished using functional near-infrared spectroscopy (fNIRS). The hemodynamic responses (HRs) in both hemispheres using fNIRS were measured in 18 subjects while exposing them to four sound categories (English-speech, non-English-speech, annoying sounds, and nature sounds). As features for classifying the different signals, the mean, slope, and skewness of the oxy-hemoglobin (HbO) signal were used. With regard to the language-related stimuli, the HRs evoked by understandable speech (English) were observed in a broader b...
Source: Hearing Research - January 29, 2016 Category: Audiology Authors: Hong KS, Santosa H Tags: Hear Res Source Type: research

3D morphometric analysis of the human incudomallear complex using clinical cone-beam CT.
We present statistical shape analysis based on clinical cone beam CT (CBCT) scans of 100 patients. This allowed us to include surface information on the incudomallear (IM) complex (joint, ligaments and tendon not included) of 123 healthy ears with a scanning resolution of 150 μm and without a priori assumptions. Statistical shape modeling yields an average geometry for the IM complex and the variations present in the population with a high precision. Mean values, variation and correlations among anatomical features (length of manubrium, combined length of malleus head and neck, lengths of incus long and short process, e...
Source: Hearing Research - January 27, 2016 Category: Audiology Authors: Soons JA, Danckaers F, Keustermans W, Huysmans T, Sijbers J, Casselman JW, Dirckx JJ Tags: Hear Res Source Type: research

Effects of auditory enhancement on the loudness of masker and target components.
Abstract Auditory enhancement refers to the observation that the salience of one spectral region (the "signal") of a broadband sound can be enhanced and can "pop out" from the remainder of the sound (the "masker") if it is preceded by the broadband sound without the signal. The present study investigated auditory enhancement as an effective change in loudness, to determine whether it reflects a change in the loudness of the signal, the masker, or both. In the first experiment, the 500-ms precursor, an inharmonic complex with logarithmically spaced components, was followed after a 50-m...
Source: Hearing Research - January 22, 2016 Category: Audiology Authors: Wang N, Oxenham AJ Tags: Hear Res Source Type: research

Interaction between osseous and non-osseous vibratory stimulation of the human cadaveric head.
l;sli C Abstract Bone conduction (BC) stimulation can be applied by vibration to the bony or skin covered skull (osseous BC), or on soft tissue such as the neck (non-osseous BC). The interaction between osseous and non-osseous bone conduction pathways is assessed in this study. The relation between bone vibrations measured at the cochlear promontory and the intracranial sound pressure for stimulation directly on the dura and for stimulation at the mastoid between 0.2 - 10 kHz was compared. First, for stimulation on the dura, varying the static coupling force of the BC transducer on the dura had only a small effect...
Source: Hearing Research - January 22, 2016 Category: Audiology Authors: Sim JH, Dobrev I, Gerig R, Pfiffner F, Stenfelt S, Huber AM, Röösli C Tags: Hear Res Source Type: research

Mechanical Damage of Tympanic Membrane in Relation to Impulse Pressure Waveform - A Study in Chinchillas.
Abstract Mechanical damage to middle ear components in blast exposure directly causes hearing loss, and the rupture of the tympanic membrane (TM) is the most frequent injury of the ear. However, it is unclear how the severity of injury graded by different patterns of TM rupture is related to the overpressure waveforms induced by blast waves. In the present study, the relationship between the TM rupture threshold and the impulse or overpressure waveform has been investigated in chinchillas. Two groups of animals were exposed to blast overpressure simulated in our lab under two conditions: open field and shielded wi...
Source: Hearing Research - January 22, 2016 Category: Audiology Authors: Gan RZ, Nakmali D, Ji XD, Leckness K, Yokell Z Tags: Hear Res Source Type: research

Comparison of Mouse Minimum Audible Angle Determined in Prepulse Inhibition and Operant Conditioning Procedures.
Abstract Both reward based operant conditioning (OC) and reflex-based prepulse inhibition (PPI) procedures are used in sound localisation studies in mice. Since the results of both procedures are compared in the literature, it is important to assess whether they provide similar results if the same stimulus paradigm is applied. Here, we compare the sensitivity of C57BL/6 mice in OC and PPI procedures for detecting a switch in speaker location using broadband and narrowband noise stimuli and determined their minimum audible angle (MAA). In the OC procedure, we calculated d' values from the hit and false alarm rates....
Source: Hearing Research - January 22, 2016 Category: Audiology Authors: Behrens D, Klump GM Tags: Hear Res Source Type: research

Pathophysiology of the cochlear intrastrial fluid-blood barrier (review).
Abstract The blood-labyrinth barrier (BLB) in the stria vascularis is a highly specialized capillary network that controls exchanges between blood and the intrastitial space in the cochlea. The barrier shields the inner ear from blood-born toxic substances and selectively passes ions, fluids, and nutrients to the cochlea, playing an essential role in the maintenance of cochlear homeostasis. Anatomically, the BLB is comprised of endothelial cells (ECs) in the strial microvasculature, elaborated tight and adherens junctions, pericytes (PCs), basement membrane (BM), and perivascular resident macrophage-like melanocyt...
Source: Hearing Research - January 20, 2016 Category: Audiology Authors: Shi X Tags: Hear Res Source Type: research

Prevalence and Audiological Profiles of GJB2 Mutations in a Large Collective of Hearing Impaired Patients.
In this study, a complete sequencing of the GJB2 gene in a cohort of 506 patients from a single, large cochlear implant program in Europe was performed. Audiological testing for those patients who could actively participate was performed using pure tone audiometry (PTA). Those unable to undergo PTA were measured using click-auditory brainstem response (ABR). Data analysis was performed to determine genotype-phenotype correlations of the mutational status vs. audiological profiles and vs. age at the time of presentation. An overall prevalence of biallelic mutations of 13.4 % was found for the total collective. When subsets ...
Source: Hearing Research - January 14, 2016 Category: Audiology Authors: Burke WF, Warnecke A, Schöner-Heinisch A, Lesinski-Schiedat A, Maier H, Lenarz T Tags: Hear Res Source Type: research

Temperature Sensitive Auditory Neuropathy.
Abstract Temperature sensitive auditory neuropathy is a very rare and puzzling disorder. In the present study, we reported three unrelated 2 to 6 year-old children who were diagnosed as auditory neuropathy patients who complained of severe hearing loss when they had fever. Their hearing thresholds varied from the morning to the afternoon. Two of these patients' hearing improved with age, and one patient received positive results from cochlear implant. Genetic analysis revealed that these three patients had otoferlin (OTOF) homozygous or compound heterozygous mutations with the genotypes c.2975_2978delAG/c.4819C>...
Source: Hearing Research - January 14, 2016 Category: Audiology Authors: Zhang Q, Lan L, Shi W, Yu L, Xie LY, Xiong F, Zhao C, Li N, Yin Z, Zong L, Guan J, Wang D, Sun W, Wang Q Tags: Hear Res Source Type: research

Auditory intensity processing: Effect of MRI background noise.
Abstract Studies on active auditory intensity discrimination in humans showed equivocal results regarding the lateralization of processing. Whereas experiments with a moderate background found evidence for right lateralized processing of intensity, functional magnetic resonance imaging (fMRI) studies with background scanner noise suggest more left lateralized processing. With the present fMRI study, we compared the task dependent lateralization of intensity processing between a conventional continuous echo planar imaging (EPI) sequence with a loud background scanner noise and a fast low-angle shot (FLASH) sequence...
Source: Hearing Research - January 14, 2016 Category: Audiology Authors: Angenstein N, Stadler J, Brechmann A Tags: Hear Res Source Type: research

A Neural-Based Vocoder Implementation for Evaluating Cochlear Implant Coding Strategies.
Abstract Most simulations of cochlear implant (CI) coding strategies rely on standard vocoders that are based on purely signal processing techniques. However, these models neither account for various biophysical phenomena, such as neural stochasticity and refractoriness, nor for effects of electrical stimulation, such as spectral smearing as a function of stimulus intensity. In this paper, a neural model that accounts for stochastic firing, parasitic spread of excitation across neuron populations, and neuronal refractoriness, was developed and augmented as a preprocessing stage for a standard 22-channel noise-band...
Source: Hearing Research - January 13, 2016 Category: Audiology Authors: El Boghdady N, Kegel A, Lai WK, Dillier N Tags: Hear Res Source Type: research

A 3D-printed functioning anatomical human middle ear model.
TC Abstract The middle ear is a sophisticated and complex structure with a variety of functions, yet a delicate organ prone to injuries due to various reasons. Both, understanding and reconstructing its functions has always been an important topic for researchers from medical and technical background. Currently, human temporal bones are generally used as model for tests, experiments and validation of the numerical results. However, fresh human preparations are not always easily accessible and their mechanical properties vary with time and between individuals. Therefore we have built an anatomically based and func...
Source: Hearing Research - January 7, 2016 Category: Audiology Authors: Kuru I, Maier H, Müller M, Lenarz T, Lueth TC Tags: Hear Res Source Type: research

The hippocampus may be more susceptible to environmental noise than the auditory cortex.
Abstract Noise exposure can cause structural and functional problem in the auditory cortex (AC) and hippocampus, the two brain regions in the auditory and non-auditory systems respectively. The aim of the present study was to explore which one of these two brain regions may be more susceptible to environmental noise. The AC and hippocampus of mice were separated following 1 or 3 weeks exposure to moderate noise (80 dB SPL, 2 h/day). The levels of oxidative stress and tau phosphorylation were then measured to evaluate the effects by noise. Results showed significant peroxidation and tau hyperphosphorylati...
Source: Hearing Research - January 7, 2016 Category: Audiology Authors: Cheng L, Wang SH, Huang Y, Liao XM Tags: Hear Res Source Type: research

Auditory and visual 3D virtual reality therapy as a new treatment for chronic subjective tinnitus: results of a randomized controlled trial.
CONCLUSION: VR appears to be at least as effective as CBT in unilateral ST patients. PMID: 26773752 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - January 7, 2016 Category: Audiology Authors: Malinvaud D, Londero A, Niarra R, Peignard P, Warusfel O, Viaud-Delmon I, Chatellier G, Bonfils P Tags: Hear Res Source Type: research

English vowel identification and vowel formant discrimination by native Mandarin Chinese- and native English-speaking listeners: the effect of vowel duration dependence.
This study revealed individual variability in using multiple acoustic cues to identify English vowels for both native and non-native listeners. PMID: 26768853 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - January 5, 2016 Category: Audiology Authors: Mi L, Tao S, Wang W, Dong Q, Guan J, Liu C Tags: Hear Res Source Type: research

Delayed low frequency hearing loss caused by cochlear implantation interventions via the round window but not cochleostomy.
This study tested whether this "delayed" hearing loss was influenced by the route of electrode array insertion and/or position of the electrode array within scala tympani in a guinea pig model of cochlear implantation. Five treatment groups were monitored over 12 weeks: (1) round window implant; (2) round window incised with no implant; (3) cochleostomy with medially-oriented implant; (4) cochleostomy with laterally-oriented implant; and (5) cochleostomy with no implant. Hearing was measured at selected time points by the auditory brainstem response. Cochlear condition was assessed histologically, with cochleae t...
Source: Hearing Research - December 29, 2015 Category: Audiology Authors: Rowe D, Chambers S, Hampson A, Eastwood H, Campbell L, O'Leary S Tags: Hear Res Source Type: research

Tinnitus: Research supported by the Tinnitus Research Consortium.
PMID: 26739791 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - December 29, 2015 Category: Audiology Authors: Ryan AF, Dobie RA, Dubno JR, Lonsbury-Martin BL Tags: Hear Res Source Type: research

Influence of the paraflocculus on normal and abnormal spontaneous firing rates in the inferior colliculus.
Abstract Spontaneous firing rates of neurons in the central auditory pathway, such as in the inferior colliculus, are known to be increased after cochlear trauma. This so-called hyperactivity is thought to be involved in the generation of tinnitus, a phantom auditory perception. Recent research in an animal model suggests behavioural signs of tinnitus can be significantly reduced by silencing or removal of the paraflocculus (PF) of the cerebellum. The current study investigated the effects of acute PF removal on spontaneous firing rates recorded from single neurons in the right inferior colliculus of guinea pigs w...
Source: Hearing Research - December 25, 2015 Category: Audiology Authors: Vogler DP, Robertson D, Mulders WH Tags: Hear Res Source Type: research

Changes in cochlear function related to acoustic stimulation of cervical vestibular evoked myogenic potential stimulation.
enfelt S Abstract Evaluation of cervical evoked myogenic potentials (c-VEMP) is commonly applied in clinical investigations of patients with suspected neurotological symptoms. Short intense acoustic stimulation of peak levels close to 130 dB SPL is required to elicit the responses. A recent publication on bilateral significant sensorineural hearing loss related to extensive VEMP stimulation motivates evaluations of immediate effects on hearing acuity related to the intense acoustic stimulation required to elicit c-VEMP responses. The aim of the current study was to investigate changes in DPOAE-levels and hear...
Source: Hearing Research - December 25, 2015 Category: Audiology Authors: Strömberg AK, Olofsson Å, Westin M, Duan M, Stenfelt S Tags: Hear Res Source Type: research

Cortical and thalamic connectivity of the auditory anterior ectosylvian cortex of early-deaf cats: Implications for neural mechanisms of crossmodal plasticity.
Abstract Early hearing loss leads to crossmodal plasticity in regions of the cerebrum that are dominated by acoustical processing in hearing subjects. Until recently, little has been known of the connectional basis of this phenomenon. One region whose crossmodal properties are well-established is the auditory field of the anterior ectosylvian sulcus (FAES) in the cat, where neurons are normally responsive to acoustic stimulation and its deactivation leads to the behavioral loss of accurate orienting toward auditory stimuli. However, in early-deaf cats, visual responsiveness predominates in the FAES and its deactiv...
Source: Hearing Research - December 24, 2015 Category: Audiology Authors: Meredith MA, Clemo HR, Corley SB, Chabot N, Lomber SG Tags: Hear Res Source Type: research

3D displacement of the middle ear ossicles in the quasi-static pressure regime using new X-ray stereoscopy technique.
Abstract A novel X-ray stereoscopy technique, using greyscale information obtained from moving markers, was used to study the 3D motion in both gerbil and rabbit middle ear ossicles in the quasi-static pressure regime. The motion can be measured without visually exposing the ossicles. The ossicles showed non-linear behaviour as a function of both pressure and frequency. For instance, about 80% of the maximum umbo displacement occurs at a 1 kPa (peak-to-peak) pressure load, while a limited increase of the amplitude is noticed when the pressure goes to 2 kPa. In rabbit the ratio of stapes to umbo motion am...
Source: Hearing Research - December 23, 2015 Category: Audiology Authors: Salih WH, Soons JJ, Dirckx JJ Tags: Hear Res Source Type: research

Outer ear canal sound pressure and bone vibration measurement in SSD and CHL patients using a transcutaneous bone conduction instrument.
Abstract The intraoperative and postoperative objective functional assessment of transcutaneous bone conduction implants is still a challenge. Here we compared intraoperative Laser-Doppler-vibrometry (LDV, Polytec Inc.) to measure vibration of the bone close to the implant to Outer Ear Canal Sound Pressure Level (OEC-SPL) measurements. Twelve single sided deafness (SSD) patients with contralateral intact ossicular chains and eight bilateral conductive hearing loss (CHL) patients were included in the study. SSD patients had a minor average air-bone-gap (ABG) of 0.4 ± 0.4 dB (0.5, 1, 2, 4 ...
Source: Hearing Research - December 23, 2015 Category: Audiology Authors: Ghoncheh M, Lilli G, Lenarz T, Maier H Tags: Hear Res Source Type: research

Acoustic richness modulates the neural networks supporting intelligible speech processing.
Abstract The information contained in a sensory signal plays a critical role in determining what neural processes are engaged. Here we used interleaved silent steady-state (ISSS) functional magnetic resonance imaging (fMRI) to explore how human listeners cope with different degrees of acoustic richness during auditory sentence comprehension. Twenty-six healthy young adults underwent scanning while hearing sentences that varied in acoustic richness (high vs. low spectral detail) and syntactic complexity (subject-relative vs. object-relative center-embedded clause structures). We manipulated acoustic richness by pre...
Source: Hearing Research - December 23, 2015 Category: Audiology Authors: Lee YS, Min NE, Wingfield A, Grossman M, Peelle JE Tags: Hear Res Source Type: research

A single-ossicle ear: Acoustic response and mechanical properties measured in duck.
This study aims to improve comprehension of this system. The acoustic response and the mechanical properties of the mallard middle ear were studied by means of optical interferometry experiments and finite element (FE) simulations. A finite element model was constructed based on μCT data and validated using the experimental results. Stroboscopic holography was used to measure the full-field displacement of the tympanic membrane (TM) under acoustic stimulation, and the transfer function was obtained with laser Doppler vibrometry. A sensitivity analysis concluded that the most influential parameters for ME mechanics are t...
Source: Hearing Research - December 23, 2015 Category: Audiology Authors: Muyshondt PG, Soons JA, De Greef D, Pires F, Aerts P, Dirckx JJ Tags: Hear Res Source Type: research

Dehydration effects of a V2 antagonist on endolymphatic hydrops in guinea pigs.
We examined the histopathology of the temporal bones and assessed volumetric changes of the endolymphatic space in the cochlea and saccule. In the second series, we investigated the effects of systemic and topical applications of OPC on plasma vasopressin (p-VP) concentrations and plasma osmolality (p-OSM). In the first series, we found that EH was reduced in the OPC 10 mg/kg systemic and OPC RW application groups. In contrast, EH increased in the OPC 100 mg/kg systemic application group. In the second series, neither p-VP levels nor p-OSM were significantly different among the non-OPC, OPC 10 mg/kg systemic...
Source: Hearing Research - December 21, 2015 Category: Audiology Authors: Egami N, Kakigi A, Takeda T, Yamasoba T Tags: Hear Res Source Type: research

Somatic memory and gain increase as preconditions for tinnitus: Insights from congenital deafness.
Abstract Tinnitus is the conscious perception of sound heard in the absence of physical sound sources internal or external to the body. The characterization of tinnitus by its spectrum reflects the missing frequencies originally represented in the hearing loss, i.e., partially or completely deafferented, region. The tinnitus percept, despite a total hearing loss, may thus be dependent on the persisting existence of a somatic memory for the "lost" frequencies. Somatic memory in this context is the reference for phantom sensations attributed to missing sensory surfaces or parts thereof. This raises the que...
Source: Hearing Research - December 21, 2015 Category: Audiology Authors: Eggermont JJ, Kral A Tags: Hear Res Source Type: research

Functional-structural reorganisation of the neuronal network for auditory perception in subjects with unilateral hearing loss: Review of neuroimaging studies.
CONCLUSION: Neuroimaging techniques could provide valuable information regarding the effects of unilateral hearing loss on both auditory and non-auditory performance. fMRI-studies showing a bilateral BOLD-response in patients with unilateral hearing loss have not yet been followed by DTI studies confirming their microstructural correlates. In addition, the review shows that an auditory modality-specific deficit could affect multi-modal brain regions and their connections. PMID: 26707432 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - December 19, 2015 Category: Audiology Authors: Heggdal PO, Brännström J, Aarstad HJ, Vassbotn FS, Specht K Tags: Hear Res Source Type: research

Longitudinal development of wideband reflectance tympanometry in normal and at-risk infants.
Abstract PURPOSE: The goals of this study were to measure normal characteristics of ambient and tympanometric wideband acoustic reflectance, which was parameterized by absorbance and group delay, in newborns cared for in well-baby and Neonatal Intensive Care Unit (NICU) nurseries, and to characterize the normal development of reflectance over the first year after birth in a group of infants with clinically normal hearing status followed longitudinally from birth to one year of age. METHODS: Infants were recruited from a well-baby and NICU nursery, passed newborn otoacoustic emissions (OAE) and automated audit...
Source: Hearing Research - December 19, 2015 Category: Audiology Authors: Hunter LL, Keefe DH, Feeney MP, Fitzpatrick DF, Lin L Tags: Hear Res Source Type: research

Partial corrosion casting to assess cochlear vasculature in mouse models of presbycusis and CMV infection.
Abstract Some forms of sensorineural hearing loss involve damage or degenerative changes to the stria vascularis and/or other vascular structures in the cochlea. In animal models, many methods for anatomical assessment of cochlear vasculature exist, each with advantages and limitations. One methodology, corrosion casting, has proved useful in some species, however in the mouse model this technique is difficult to achieve because digestion of non vascular tissue results in collapse of the delicate cast specimen. We have developed a partial corrosion cast method that allows visualization of vasculature along much of...
Source: Hearing Research - December 18, 2015 Category: Audiology Authors: Carraro M, Park AH, Harrison RV Tags: Hear Res Source Type: research

Hearing it right: Evidence of hemispheric lateralization in auditory imagery.
Abstract An advantage of the right ear (REA) in auditory processing (especially for verbal content) has been firmly established in decades of behavioral, electrophysiological and neuroimaging research. The laterality of auditory imagery, however, has received little attention, despite its potential relevance for the understanding of auditory hallucinations and related phenomena. In Experiments 1-4 we find that right-handed participants required to imagine hearing a voice or a sound unilaterally show a strong population bias to localize the self-generated auditory image at their right ear, likely the result of left...
Source: Hearing Research - December 17, 2015 Category: Audiology Authors: Prete G, Marzoli D, Brancucci A, Tommasi L Tags: Hear Res Source Type: research

Low-frequency sound exposure causes reversible long-term changes of cochlear transfer characteristics.
e E Abstract Intense, low-frequency sound presented to the mammalian cochlea induces temporary changes of cochlear sensitivity, for which the term 'Bounce' phenomenon has been coined. Typical manifestations are slow oscillations of hearing thresholds or the level of otoacoustic emissions. It has been suggested that these alterations are caused by changes of the mechano-electrical transducer transfer function of outer hair cells (OHCs). Shape estimates of this transfer function can be derived from low-frequency-biased distortion product otoacoustic emissions (DPOAE). Here, we tracked the transfer function estimates...
Source: Hearing Research - December 17, 2015 Category: Audiology Authors: Drexl M, Otto L, Wiegrebe L, Marquardt T, Gürkov R, Krause E Tags: Hear Res Source Type: research

Perception of stochastic envelopes by normal-hearing and cochlear-implant listeners.
Abstract We assessed auditory sensitivity to three classes of temporal-envelope statistics (modulation depth, modulation rate, and comodulation) that are important for the perception of 'sound textures'. The textures were generated by a probabilistic model that prescribes the temporal statistics of a selected number of modulation envelopes, superimposed onto noise carriers. Discrimination thresholds were measured for normal-hearing (NH) listeners and users of a MED-EL pulsar cochlear implant (CI), for separate manipulations of the average rate and modulation depth of the envelope in each frequency band of the stim...
Source: Hearing Research - December 17, 2015 Category: Audiology Authors: Gomersall PA, Turner RE, Baguley DM, Deeks JM, Gockel HE, Carlyon RP Tags: Hear Res Source Type: research

Large-scale phenotyping of noise-induced hearing loss in 100 strains of mice.
In this study, we further expand upon the existing literature by characterizing the baseline ABR characteristics of 100 inbred mouse strains, 47 of which are newly characterized for hearing function. We identify several distinct patterns of baseline hearing deficits and provide potential avenues for further investigation. Additionally, we characterize the sensitivity of the same 100 strains to noise exposure using permanent thresholds shifts, identifying several distinct patterns of noise-sensitivity. The resulting data provides a new resource for studying hearing loss and noise-sensitivity in mice. PMID: 26706709 [Pu...
Source: Hearing Research - December 17, 2015 Category: Audiology Authors: Myint A, White CH, Ohmen JD, Li X, Wang J, Lavinsky J, Salehi P, Crow AL, Ohyama T, Friedman RA Tags: Hear Res Source Type: research

Pressure buffering by the tympanic membrane. In vivo measurements of middle ear pressure fluctuations during elevator motion.
CONCLUSIONS: These results were in fair agreement with the literature obtained in clinical as well as temporal bone experiments, and they provide an in vivo reference for the normal ME function as well as for ME modeling. The TM buffer capacity was found more efficient in smaller mastoids. Possible clinical implications are discussed. PMID: 26701784 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - December 14, 2015 Category: Audiology Authors: Padurariu S, de Greef D, Jacobsen H, Kamavuako EN, Dirckx JJ, Gaihede M Tags: Hear Res Source Type: research

Determination of the mastoid surface area and volume based on micro-CT scanning of human temporal bones. Geometrical parameters depend on scanning resolutions.
Abstract The mastoid air cell system (MACS) with its large complex of interconnected air cells reflects an enhanced surface area (SA) relative to its volume (V), which may indicate that the MACS is adapted to gas exchange and has a potential role in middle ear pressure regulation. These geometric parameters of the MACS have been studied by high resolution clinical CT scanning. However, the resolution of these scans is limited to a voxel size of around 0.6 mm in all dimensions, and so, the geometrical parameters are also limited. Small air cells may appear below the resolution and cannot be detected. Such air cells...
Source: Hearing Research - December 14, 2015 Category: Audiology Authors: Cros O, Knutsson H, Andersson M, Pawels E, Borga M, Gaihede M Tags: Hear Res Source Type: research

On the connection between the tympanic membrane and the malleus.
CONCLUSION: Our data confirm that a large inter-individual variability exists in the properties of the TM-malleus connection in humans in terms of its dimensions, tissue composition and configuration. Average data and their variability margins will be useful input for testing the importance of the TMC in finite element models. PMID: 26701786 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - December 14, 2015 Category: Audiology Authors: De Greef D, Goyens J, Pintelon I, Bogers JP, Van Rompaey V, Hamans E, Van de Heyning P, Dirckx JJ Tags: Hear Res Source Type: research

Hair cell regeneration or the expression of related factors that regulate the fate specification of supporting cells in the cochlear ducts of embryonic and posthatch chickens.
This study is the first to indicate that unlike hair cells in posthatch chickens, the auditory epithelium was free from antibiotic injury (25-250 mg gentamicin/kg) in embryonic chickens, although FITC-conjugated gentamicin actually reached embryonic hair cells. Next, we examined and counted the cells and performed labeling for BrdU, Sox2, Atoh1/Math1, PV or p27(kip1) (triple or double labeling) in the injured cochlea ducts after gentamicin treatment at 2 hours (h), 15 h, 24 h, 2 days (d), 3 d and 7 d after BrdU treatment in posthatch chickens. Our results indicated that following gentamicin administration, proliferating ce...
Source: Hearing Research - December 11, 2015 Category: Audiology Authors: Jiang L, Jin R, Xu J, Ji Y, Zhang M, Zhang X, Zhang X, Han Z, Zeng S Tags: Hear Res Source Type: research

Modulation of Auditory Brainstem Responses by Serotonin and Specific Serotonin Receptors.
Abstract The neuromodulator serotonin is found throughout the auditory system from the cochlea to the cortex. Although effects of serotonin have been reported at the level of single neurons in many brainstem nuclei, how these effects correspond to more integrated measures of auditory processing has not been well-explored. In the present study, we aimed to characterize the effects of serotonin on far-field auditory brainstem responses (ABR) across a wide range of stimulus frequencies and intensities. Using a mouse model, we investigated the consequences of systemic serotonin depletion, as well as the selective stim...
Source: Hearing Research - December 11, 2015 Category: Audiology Authors: Papesh MA, Hurley LM Tags: Hear Res Source Type: research

Sodium salicylate potentiates the GABAB-GIRK pathway to suppress rebound depolarization in neurons of the rat's medial geniculate body.
Abstract Rebound depolarization (RD) is a voltage response to the offset from pre-hyperpolarization of neuronal membrane potential, which manifests a particular form of the postsynaptic membrane potential response to inhibitory presynaptic inputs. We previously demonstrated that sodium salicylate (NaSal), a tinnitus inducer, can drastically suppress the RD in neurons of rat medial geniculate body (MGB) (Su et al, 2012, PLoS ONE 7, e46969). The purpose of the present study was to investigate the underlying cellular mechanism by using whole-cell patch-clamp recordings in rat MGB slices. NaSal (1.4 mM) had no effects...
Source: Hearing Research - December 11, 2015 Category: Audiology Authors: Wang XX, Jin Y, Luo B, Sun JW, Zhang J, Wang M, Chen L Tags: Hear Res Source Type: research

PMID: 26643448 [PubMed - in process] (Source: Hearing Research)
Source: Hearing Research - December 1, 2015 Category: Audiology Authors: Ito J Tags: Hear Res Source Type: research

Assessment of thermal treatment via irrigation of external ear to reduce cisplatin-induced hearing loss.
Abstract Systemic and local changes in body temperature can have a profound effect on traumatic injuries including those to the inner ear. Therefore, we investigated the effects of acutely increasing or decreasing the temperature of the external ear canal on cisplatin-induced hearing loss. The external auditory canals of male guinea pigs were acutely irrigated with warm (44 °C), euthermic (37 °C), or cool (30 °C) water and subsequently injected with cisplatin (12 mg/kg, i.p.). Hearing was assessed by the auditory brainstem response and cochleograms were prepared to determine loss of hair cells. Ear can...
Source: Hearing Research - November 27, 2015 Category: Audiology Authors: Spankovich C, Lobarinas E, Ding D, Salvi R, Le Prell CG Tags: Hear Res Source Type: research

FGF22 protects hearing function from gentamycin ototoxicity by maintaining ribbon synapse number.
Abstract Inner hair cell (IHC) ribbon synapses of cochlea play important role in transmitting sound signal into auditory nerve and are sensitive to ototoxicity. However, ototoxic damage of ribbon synapses is not understood clearly. Roles of fibroblast growth factor 22 (FGF22) on synapse formation were explored under gentamycin ototoxicity. 6-week-old mice were injected intraperitoneally once daily with 50-150 mg/kg gentamicin for 10 days. Immunostaining with anti- GluR2&3/CtBP2 was used to estimate the number of ribbon synapses in the cochlea. Expression of FGF22 and myocyte enhancer factor 2D (MEF2D) was assa...
Source: Hearing Research - November 27, 2015 Category: Audiology Authors: Li S, Hang L, Ma Y Tags: Hear Res Source Type: research

A DPOAE assessment of outer hair cell integrity in ears with age-related hearing loss.
Abstract Distortion product otoacoustic emissions (DPOAEs) were used to assess outer hair cell (OHC) integrity in human ears with age-related hearing loss. Sound pressure measurements were made in the ear canal over the stimulus range 40 to 90 dB SPL (L2), with L1=0.45*L2+44 with F2 = 2 and 3 or 4 kHz. Model-generated DPOAE I/O functions were fit to DPOAE data to quantify the contribution of loss of nonlinearity (OHC loss) to the hearing loss. Results suggest OHC loss as a contributing cause of age-related hearing, regardless of audiogram configuration. It seems likely that OHC and strial pathology co-exist in ear...
Source: Hearing Research - November 27, 2015 Category: Audiology Authors: Ueberfuhr MA, Fehlberg H, Goodman SS, Withnell RH Tags: Hear Res Source Type: research

Cooling of the auditory cortex modifies neuronal activity in the inferior colliculus in rats.
nko K, Chumak T, Syka J Abstract There are powerful pathways descending from the auditory cortex (AC) to the inferior colliculus (IC), yet their function is not fully understood. The aim of this study is to examine the effects of a reversible cortical inactivation, achieved by cooling of the AC, on the responses of neurons in the rat IC. Extracellular single-unit or multi-unit activity was recorded in the IC of anaesthetized rats with a 16-channel multielectrode probe introduced along the IC dorso-ventral axis through the dorsal cortex (DCIC) to the central nucleus of the IC (CIC). Cooling of the AC produced an in...
Source: Hearing Research - November 26, 2015 Category: Audiology Authors: Popelář J, Šuta D, Lindovský J, Bureš Z, Pysanenko K, Chumak T, Syka J Tags: Hear Res Source Type: research

Biomechanics of the incudo-malleolar-joint - Experimental investigations for quasi-static loads.
Eiber A Abstract Under large quasi-static loads, the incudo-malleolar joint (IMJ), connecting the malleus and the incus, is highly mobile. It can be classified as a mechanical filter decoupling large quasi-static motions while transferring small dynamic excitations. This is presumed to be due to the complex geometry of the joint inducing a spatial decoupling between the malleus and incus under large quasi-static loads. Spatial Laser Doppler Vibrometer (LDV) displacement measurements on isolated malleus-incus-complexes (MICs) were performed. With the malleus firmly attached to a probe holder, the incus was excited ...
Source: Hearing Research - November 25, 2015 Category: Audiology Authors: Ihrle S, Gerig R, Dobrev I, Röösli C, Sim JH, Huber AM, Eiber A Tags: Hear Res Source Type: research