Potential roles for lncRNA Mirg/Foxp1 in an ARHL model created using C57BL/6J mice
In conclusion, our findings suggest that lncRNA Mirg expression correlates with cell apoptosis-associated mRNAs in the ARHL model created using C57BL/6 J mice and that oxidative stress-induced lncRNA Mirg promotes HEI-OC1 cell apoptosis by increasing Foxp1 expression. These data suggest the potential therapeutic significance of targeting lncRNA Mirg/Foxp1 signaling in ARHL.PMID:37579646 | DOI:10.1016/j.heares.2023.108859 (Source: Hearing Research)
Source: Hearing Research - August 14, 2023 Category: Audiology Authors: Xiaoqin Luo Yaqin Hu Xiaoqing Zhou Chanyuan Zhang Menglong Feng Ting Yang Wei Yuan Source Type: research
Potential roles for lncRNA Mirg/Foxp1 in an ARHL model created using C57BL/6J mice
In conclusion, our findings suggest that lncRNA Mirg expression correlates with cell apoptosis-associated mRNAs in the ARHL model created using C57BL/6 J mice and that oxidative stress-induced lncRNA Mirg promotes HEI-OC1 cell apoptosis by increasing Foxp1 expression. These data suggest the potential therapeutic significance of targeting lncRNA Mirg/Foxp1 signaling in ARHL.PMID:37579646 | DOI:10.1016/j.heares.2023.108859 (Source: Hearing Research)
Source: Hearing Research - August 14, 2023 Category: Audiology Authors: Xiaoqin Luo Yaqin Hu Xiaoqing Zhou Chanyuan Zhang Menglong Feng Ting Yang Wei Yuan Source Type: research
Potential roles for lncRNA Mirg/Foxp1 in an ARHL model created using C57BL/6J mice
In conclusion, our findings suggest that lncRNA Mirg expression correlates with cell apoptosis-associated mRNAs in the ARHL model created using C57BL/6 J mice and that oxidative stress-induced lncRNA Mirg promotes HEI-OC1 cell apoptosis by increasing Foxp1 expression. These data suggest the potential therapeutic significance of targeting lncRNA Mirg/Foxp1 signaling in ARHL.PMID:37579646 | DOI:10.1016/j.heares.2023.108859 (Source: Hearing Research)
Source: Hearing Research - August 14, 2023 Category: Audiology Authors: Xiaoqin Luo Yaqin Hu Xiaoqing Zhou Chanyuan Zhang Menglong Feng Ting Yang Wei Yuan Source Type: research
Potential roles for lncRNA Mirg/Foxp1 in an ARHL model created using C57BL/6J mice
In conclusion, our findings suggest that lncRNA Mirg expression correlates with cell apoptosis-associated mRNAs in the ARHL model created using C57BL/6 J mice and that oxidative stress-induced lncRNA Mirg promotes HEI-OC1 cell apoptosis by increasing Foxp1 expression. These data suggest the potential therapeutic significance of targeting lncRNA Mirg/Foxp1 signaling in ARHL.PMID:37579646 | DOI:10.1016/j.heares.2023.108859 (Source: Hearing Research)
Source: Hearing Research - August 14, 2023 Category: Audiology Authors: Xiaoqin Luo Yaqin Hu Xiaoqing Zhou Chanyuan Zhang Menglong Feng Ting Yang Wei Yuan Source Type: research
Potential roles for lncRNA Mirg/Foxp1 in an ARHL model created using C57BL/6J mice
In conclusion, our findings suggest that lncRNA Mirg expression correlates with cell apoptosis-associated mRNAs in the ARHL model created using C57BL/6 J mice and that oxidative stress-induced lncRNA Mirg promotes HEI-OC1 cell apoptosis by increasing Foxp1 expression. These data suggest the potential therapeutic significance of targeting lncRNA Mirg/Foxp1 signaling in ARHL.PMID:37579646 | DOI:10.1016/j.heares.2023.108859 (Source: Hearing Research)
Source: Hearing Research - August 14, 2023 Category: Audiology Authors: Xiaoqin Luo Yaqin Hu Xiaoqing Zhou Chanyuan Zhang Menglong Feng Ting Yang Wei Yuan Source Type: research
Potential roles for lncRNA Mirg/Foxp1 in an ARHL model created using C57BL/6J mice
In conclusion, our findings suggest that lncRNA Mirg expression correlates with cell apoptosis-associated mRNAs in the ARHL model created using C57BL/6 J mice and that oxidative stress-induced lncRNA Mirg promotes HEI-OC1 cell apoptosis by increasing Foxp1 expression. These data suggest the potential therapeutic significance of targeting lncRNA Mirg/Foxp1 signaling in ARHL.PMID:37579646 | DOI:10.1016/j.heares.2023.108859 (Source: Hearing Research)
Source: Hearing Research - August 14, 2023 Category: Audiology Authors: Xiaoqin Luo Yaqin Hu Xiaoqing Zhou Chanyuan Zhang Menglong Feng Ting Yang Wei Yuan Source Type: research
Auditory cortex and beyond: Deficits in congenital amusia
Hear Res. 2023 Jul 23;437:108855. doi: 10.1016/j.heares.2023.108855. Online ahead of print.ABSTRACTCongenital amusia is a neuro-developmental disorder of music perception and production, with the observed deficits contrasting with the sophisticated music processing reported for the general population. Musical deficits within amusia have been hypothesized to arise from altered pitch processing, with impairments in pitch discrimination and, notably, short-term memory. We here review research investigating its behavioral and neural correlates, in particular the impairments at encoding, retention, and recollection of pitch inf...
Source: Hearing Research - August 12, 2023 Category: Audiology Authors: Barbara Tillmann Jackson E Graves Francesca Talamini Yohana L évêque Lesly Fornoni Caliani Hoarau Agathe Pralus J érémie Ginzburg Philippe Albouy Anne Caclin Source Type: research
Auditory cortex and beyond: Deficits in congenital amusia
Hear Res. 2023 Jul 23;437:108855. doi: 10.1016/j.heares.2023.108855. Online ahead of print.ABSTRACTCongenital amusia is a neuro-developmental disorder of music perception and production, with the observed deficits contrasting with the sophisticated music processing reported for the general population. Musical deficits within amusia have been hypothesized to arise from altered pitch processing, with impairments in pitch discrimination and, notably, short-term memory. We here review research investigating its behavioral and neural correlates, in particular the impairments at encoding, retention, and recollection of pitch inf...
Source: Hearing Research - August 12, 2023 Category: Audiology Authors: Barbara Tillmann Jackson E Graves Francesca Talamini Yohana L évêque Lesly Fornoni Caliani Hoarau Agathe Pralus J érémie Ginzburg Philippe Albouy Anne Caclin Source Type: research
Facilitation properties in electrically evoked compound action potentials depending on spatial location and on threshold
In this study, we quantified intracochlear variation of the facilitation properties in cochlear implants (CI) using ECAPs. We hypothesized that the facilitation effect is dependent on the electrode channel and its ECAP threshold. Therefore, ECAPs were recorded in 23 CI subjects. For each subject, five default (channel-derived) and up to two additional (threshold-derived) stimulation sites were defined. Facilitation was quantified by the paradigm introduced by (Hey et al., 2017) with optimized parameter settings. For each channel the maximum facilitated amplitude was determined by a series of ECAP measurements. A linear mix...
Source: Hearing Research - August 9, 2023 Category: Audiology Authors: Jan Dambon Alexander Mewes Annika Beyer Jakob Dambon Petra Ambrosch Matthias Hey Source Type: research
Facilitation properties in electrically evoked compound action potentials depending on spatial location and on threshold
In this study, we quantified intracochlear variation of the facilitation properties in cochlear implants (CI) using ECAPs. We hypothesized that the facilitation effect is dependent on the electrode channel and its ECAP threshold. Therefore, ECAPs were recorded in 23 CI subjects. For each subject, five default (channel-derived) and up to two additional (threshold-derived) stimulation sites were defined. Facilitation was quantified by the paradigm introduced by (Hey et al., 2017) with optimized parameter settings. For each channel the maximum facilitated amplitude was determined by a series of ECAP measurements. A linear mix...
Source: Hearing Research - August 9, 2023 Category: Audiology Authors: Jan Dambon Alexander Mewes Annika Beyer Jakob Dambon Petra Ambrosch Matthias Hey Source Type: research
Facilitation properties in electrically evoked compound action potentials depending on spatial location and on threshold
In this study, we quantified intracochlear variation of the facilitation properties in cochlear implants (CI) using ECAPs. We hypothesized that the facilitation effect is dependent on the electrode channel and its ECAP threshold. Therefore, ECAPs were recorded in 23 CI subjects. For each subject, five default (channel-derived) and up to two additional (threshold-derived) stimulation sites were defined. Facilitation was quantified by the paradigm introduced by (Hey et al., 2017) with optimized parameter settings. For each channel the maximum facilitated amplitude was determined by a series of ECAP measurements. A linear mix...
Source: Hearing Research - August 9, 2023 Category: Audiology Authors: Jan Dambon Alexander Mewes Annika Beyer Jakob Dambon Petra Ambrosch Matthias Hey Source Type: research
Cortical networks for recognition of speech with simultaneous talkers
Hear Res. 2023 Jul 24;437:108856. doi: 10.1016/j.heares.2023.108856. Online ahead of print.ABSTRACTThe relative contributions of superior temporal vs. inferior frontal and parietal networks to recognition of speech in a background of competing speech remain unclear, although the contributions themselves are well established. Here, we use fMRI with spectrotemporal modulation transfer function (ST-MTF) modeling to examine the speech information represented in temporal vs. frontoparietal networks for two speech recognition tasks with and without a competing talker. Specifically, 31 listeners completed two versions of a three-...
Source: Hearing Research - August 2, 2023 Category: Audiology Authors: Christian Herrera Nicole Whittle Marjorie R Leek Christian Brodbeck Grace Lee Caleb Barcenas Samuel Barnes Barbara Holshouser Alex Yi Jonathan H Venezia Source Type: research
Cortical networks for recognition of speech with simultaneous talkers
Hear Res. 2023 Jul 24;437:108856. doi: 10.1016/j.heares.2023.108856. Online ahead of print.ABSTRACTThe relative contributions of superior temporal vs. inferior frontal and parietal networks to recognition of speech in a background of competing speech remain unclear, although the contributions themselves are well established. Here, we use fMRI with spectrotemporal modulation transfer function (ST-MTF) modeling to examine the speech information represented in temporal vs. frontoparietal networks for two speech recognition tasks with and without a competing talker. Specifically, 31 listeners completed two versions of a three-...
Source: Hearing Research - August 2, 2023 Category: Audiology Authors: Christian Herrera Nicole Whittle Marjorie R Leek Christian Brodbeck Grace Lee Caleb Barcenas Samuel Barnes Barbara Holshouser Alex Yi Jonathan H Venezia Source Type: research
Cortical networks for recognition of speech with simultaneous talkers
Hear Res. 2023 Jul 24;437:108856. doi: 10.1016/j.heares.2023.108856. Online ahead of print.ABSTRACTThe relative contributions of superior temporal vs. inferior frontal and parietal networks to recognition of speech in a background of competing speech remain unclear, although the contributions themselves are well established. Here, we use fMRI with spectrotemporal modulation transfer function (ST-MTF) modeling to examine the speech information represented in temporal vs. frontoparietal networks for two speech recognition tasks with and without a competing talker. Specifically, 31 listeners completed two versions of a three-...
Source: Hearing Research - August 2, 2023 Category: Audiology Authors: Christian Herrera Nicole Whittle Marjorie R Leek Christian Brodbeck Grace Lee Caleb Barcenas Samuel Barnes Barbara Holshouser Alex Yi Jonathan H Venezia Source Type: research
Cortical networks for recognition of speech with simultaneous talkers
Hear Res. 2023 Jul 24;437:108856. doi: 10.1016/j.heares.2023.108856. Online ahead of print.ABSTRACTThe relative contributions of superior temporal vs. inferior frontal and parietal networks to recognition of speech in a background of competing speech remain unclear, although the contributions themselves are well established. Here, we use fMRI with spectrotemporal modulation transfer function (ST-MTF) modeling to examine the speech information represented in temporal vs. frontoparietal networks for two speech recognition tasks with and without a competing talker. Specifically, 31 listeners completed two versions of a three-...
Source: Hearing Research - August 2, 2023 Category: Audiology Authors: Christian Herrera Nicole Whittle Marjorie R Leek Christian Brodbeck Grace Lee Caleb Barcenas Samuel Barnes Barbara Holshouser Alex Yi Jonathan H Venezia Source Type: research
