Amplitude-modulation detection by gerbils in reverberant sound fields.
Abstract Reverberation can dramatically reduce the depth of amplitude modulations which are critical for speech intelligibility. Psychophysical experiments indicate that humans' sensitivity to amplitude modulation in reverberation is better than predicted from the acoustic modulation depth at the receiver position. Electrophysiological studies on reverberation in rabbits highlight the contribution of neurons sensitive to interaural correlation. Here, we use a prepulse-inhibition paradigm to quantify the gerbils' amplitude modulation threshold in both anechoic and reverberant virtual environments. Data show that pr...
Source: Hearing Research - April 18, 2013 Category: Audiology Authors: Lingner A, Kugler K, Grothe B, Wiegrebe L Tags: Hear Res Source Type: research
How do auditory cortex neurons represent communication sounds?
ne JM Abstract A major goal in auditory neuroscience is to characterize how communication sounds are represented at the cortical level. The present review aims at investigating the role of auditory cortex in the processing of speech, bird songs and other vocalizations, which all are spectrally and temporally highly structured sounds. Whereas earlier studies have simply looked for neurons exhibiting higher firing rates to particular conspecific vocalizations over their modified, artificially synthesized versions, more recent studies determined the coding capacity of temporal spike patterns, which are prominent in p...
Source: Hearing Research - April 17, 2013 Category: Audiology Authors: Gaucher Q, Huetz C, Gourévitch B, Laudanski J, Occelli F, Edeline JM Tags: Hear Res Source Type: research
MEMRO 2012 - Middle-ear bridge between science and otology.
PMID: 23598165 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - April 15, 2013 Category: Audiology Authors: Cho JH, Puria S, Gummer AW Tags: Hear Res Source Type: research
Investigation of bacterial biofilm in the human middle ear using optical coherence tomography and acoustic measurements.
This article is part of a Special Issue entitled "MEMRO 2012". PMID: 23588039 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - April 12, 2013 Category: Audiology Authors: Nguyen CT, Robinson SR, Jung W, Novak MA, Boppart SA, Allen JB Tags: Hear Res Source Type: research
Insensitivity of the audiogram to carboplatin induced inner hair cell loss in chinchillas.
Abstract Noise trauma, aging, and ototoxicity preferentially damage the outer hair cells of the inner ear, leading to increased hearing thresholds and poorer frequency resolution. Whereas outer hair cells make synaptic connections with less than 10% of afferent auditory nerve fibers (type-II), inner hair cells make connections with over 90% of afferents (type-I). Despite these extensive connections, little is known about how selective inner hair cell loss impacts hearing. In chinchillas, moderate to high doses of the anticancer compound carboplatin produce selective inner hair cell and type-I afferent loss with li...
Source: Hearing Research - April 6, 2013 Category: Audiology Authors: Lobarinas E, Salvi R, Ding D Tags: Hear Res Source Type: research
Musicians change their tune: How hearing loss alters the neural code.
Abstract Individuals with sensorineural hearing loss have difficulty understanding speech, especially in background noise. This deficit remains even when audibility is restored through amplification, suggesting that mechanisms beyond a reduction in peripheral sensitivity contribute to the perceptual difficulties associated with hearing loss. Given that normal-hearing musicians have enhanced auditory perceptual skills, including speech-in-noise perception, coupled with heightened subcortical responses to speech, we aimed to determine whether similar advantages could be observed in middle-aged adults with hearing lo...
Source: Hearing Research - April 6, 2013 Category: Audiology Authors: Parbery-Clark A, Anderson S, Kraus N Tags: Hear Res Source Type: research
Superior-semicircular-canal dehiscence: Effects of location, shape, and size on sound conduction.
In this study, BC excitations were simulated by applying rigid-body vibrations to the model along the directions of the (arbitrarily defined) x, y, and z axes of the model. Simulation results are consistent with previous clinical measurements on patients with an SSCD and with results from earlier lumped-element electrical-circuit modeling studies, with the dehiscence decreasing the hearing threshold (i.e., increasing vBM) by about 35 dB for BC excitation at low frequencies, while for AC excitation the dehiscence increases the hearing threshold (i.e., decreases vBM) by about 15 dB. A new finding from this study is...
Source: Hearing Research - April 3, 2013 Category: Audiology Authors: Kim N, Steele CR, Puria S Tags: Hear Res Source Type: research
Loudness functions with air and bone conduction stimulation in normal-hearing subjects using a categorical loudness scaling procedure.
This article is part of a Special Issue entitled "MEMRO 2012". PMID: 23562775 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - April 3, 2013 Category: Audiology Authors: Stenfelt S, Zeitooni M Tags: Hear Res Source Type: research
The dominant role of inhibition in creating response selectivities for communication calls in the brainstem auditory system.
Abstract This review is concerned with how communication calls are processed and represented by populations of neurons in both the inferior colliculus (IC), the auditory midbrain nucleus, and the dorsal nucleus of the lateral lemniscus (DNLL), the nucleus just caudal to the IC. The review has five sections where focus in each section is on inhibition and its role in shaping response selectivity for communication calls. In the first section, the lack of response selectivity for calls in DNLL neurons is presented and discusses why inhibition plays virtually no role in shaping selectivity. In the second section, the ...
Source: Hearing Research - March 29, 2013 Category: Audiology Authors: Pollak GD Tags: Hear Res Source Type: research
Characterizing the ear canal acoustic impedance and reflectance by pole-zero fitting.
This study characterizes middle ear complex acoustic reflectance (CAR) and impedance by fitting poles and zeros to real-ear measurements. The goal of this work is to establish a quantitative connection between pole-zero locations and the underlying physical properties of CAR data. Most previous studies have analyzed CAR magnitude; while the magnitude accounts for reflected power, it does not encode latency information. Thus, an analysis that studies the real and imaginary parts of the data together, being more general, should be more powerful. Pole-zero fitting of CAR data is examined using data compiled from various studi...
Source: Hearing Research - March 22, 2013 Category: Audiology Authors: Robinson SR, Nguyen CT, Allen JB Tags: Hear Res Source Type: research
Micro-channels in the mastoid anatomy. Indications of a separate blood supply of the air cell system mucosa by micro-CT scanning.
In this study we have applied micro-CT scanning on a series of three human temporal bones. This approach greatly enhances the resolution (40-60 μm), so that we have discovered anatomical details, which has not been reported earlier. Thus, qualitative analysis using volume rendering has demonstrated notable micro-channels connecting the surface of the compact bone directly to the mastoid air cells as well as forming a network of connections between the air cells. Quantitative analysis on 2D slices was employed to determine the average diameter of these micro-channels (158 μm; range = 40-440 &m...
Source: Hearing Research - March 19, 2013 Category: Audiology Authors: Cros O, Borga M, Pauwels E, Dirckx JJ, Gaihede M Tags: Hear Res Source Type: research
The Bonebridge: Preclinical evaluation of a new transcutaneously-activated bone anchored hearing device.
CONCLUSIONS: Preclinical results imply that the BB has functional performance similar to the BAHA and could be beneficial to patients suffering with conductive and mixed hearing losses as well as for those with unilateral impairment. Based on these preliminary results, a carefully designed clinical trial with conservative inclusion criteria can be recommended. This article is part of a Special Issue entitled "MEMRO 2012". PMID: 23467173 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - March 1, 2013 Category: Audiology Authors: Huber AM, Sim JH, Xie YZ, Chatzimichalis M, Ullrich O, Röösli C Tags: Hear Res Source Type: research
Two-port network analysis and modeling of a balanced armature receiver.
This study analyzes a widely-used commercial hearing-aid receiver ED series, manufactured by Knowles Electronics, Inc. Electromagnetic transducer modeling must consider two key elements: a semi-inductor and a gyrator. The semi-inductor accounts for electromagnetic eddy-currents, the 'skin effect' of a conductor (Vanderkooy, 1989), while the gyrator (McMillan, 1946; Tellegen, 1948) accounts for the anti-reciprocity characteristic [Lenz's law (Hunt, 1954, p. 113)]. Aside from Hunt (1954), no publications we know of have included the gyrator element in their electromagnetic transducer models. The most prevalent method of tran...
Source: Hearing Research - February 26, 2013 Category: Audiology Authors: Kim N, Allen JB Tags: Hear Res Source Type: research
Estimation of bone conduction skull transmission by hearing thresholds and ear-canal sound pressure.
on B Abstract Bone conduction sound transmission in the human skull and the occlusion effect were estimated from hearing thresholds and ear-canal sound pressure (ECSP) measured by a probe tube microphone when stimulation was at three positions on the skull (ipsilateral mastoid, contralateral mastoid, and forehead). The measurements were done with the ear-canal open as well as occluded by an ear-plug. Depending on the estimation method, transcranial transmission at frequencies below 1 kHz was between -8 and 5 dB, around 0 dB at 1 kHz that decreased with frequency to between -17 and -7 dB at 8 kHz. The forehead tran...
Source: Hearing Research - February 16, 2013 Category: Audiology Authors: Reinfeldt S, Stenfelt S, Håkansson B Tags: Hear Res Source Type: research
Current concepts in age-related hearing loss: epidemiology and mechanistic pathways.
Abstract Age-related hearing loss (AHL), also known as presbycusis, is a universal feature of mammalian aging and is characterized by a decline of auditory function, such as increased hearing thresholds and poor frequency resolution. The primary pathology of AHL includes the hair cells, stria vascularis, and afferent spiral ganglion neurons as well as the central auditory pathways. A growing body of evidence in animal studies has suggested that cumulative effect of oxidative stress could induce damage to macromolecules such as mitochondrial DNA (mtDNA) and that the resulting accumulation of mtDNA mutations/deletio...
Source: Hearing Research - February 16, 2013 Category: Audiology Authors: Yamasoba T, Lin FR, Someya S, Kashio A, Sakamoto T, Kondo K Tags: Hear Res Source Type: research
Neural substrates predicting improvement of tinnitus after cochlear implantation in patients with single-sided deafness.
Abstract Notwithstanding successful reduction of tinnitus after cochlear implantation (CI) in patients with single-sided deafness (SSD) in recent studies, neither the exact mechanism of suppression nor the predictors of the amount of improvement are fully understood yet. We collected quantitative electroencephalography (qEEG) data from nine SSD patients who underwent CI for tinnitus management. By correlating the degree of improvement in tinnitus intensity and tinnitus-related distress with preoperative source-localized qEEG findings and comparing qEEG findings of patients with marked improvement after CI with tho...
Source: Hearing Research - February 13, 2013 Category: Audiology Authors: Song JJ, Punte AK, De Ridder D, Vanneste S, Van de Heyning P Tags: Hear Res Source Type: research
Stem Cell Transplantation via the Cochlear Lateral Wall for Replacement of Degenerated Spiral Ganglion Neurons.
In this study, we attempted to establish a new stem cell transplantation route into the cochlea via the cochlear lateral wall (CLW). First, we tested the precision of this route by injecting Fluorogold into the CLW and next assessed its safety by mock surgeries. Then, using a degenerated SGN animal model, we transplanted neural stem cells (NSCs), derived from the olfactory bulb of C57BL/6- green fluorescent protein (GFP) mice, via the CLW route and examined the cells' distribution in the cochlea. We found the CLW transplantation route is precise and safe. In addition, NSCs migrated into RC with a high efficiency and differ...
Source: Hearing Research - February 9, 2013 Category: Audiology Authors: Zhang PZ, He Y, Jiang XW, Chen FQ, Chen Y, Shi L, Chen J, Chen X, Li X, Xue T, Wang Y, Mi WJ, Qiu JH Tags: Hear Res Source Type: research
Expression and Dexamethasone-induced Nuclear Translocation of Glucocorticoid and Mineralocorticoid Receptors in Guinea Pig Cochlear Cells.
Abstract Glucocorticoids (GC) are powerful anti-inflammatory agents frequently used to protect the auditory organ against damage associated with a variety of conditions, including noise exposure and ototoxic drugs as well as bacterial and viral infections. In addition to glucocorticoid receptors (GC-R), natural and synthetic GC are known to bind mineralocorticoid receptors (MC-R) with great affinity. We used light and laser scanning confocal microscopy to investigate the expression of GC-R and MC-R in different cell populations of the guinea pig cochlea, and their translocation to different cell compartments after...
Source: Hearing Research - February 8, 2013 Category: Audiology Authors: Kil SH, Kalinec F Tags: Hear Res Source Type: research
Understanding the effect of noise on electrical stimulation sequences in cochlear implants and its impact on speech intelligibility.
Abstract The present study investigates the most important factors that limit the intelligibility of the cochlear implant (CI) processed speech in noisy environments. The electrical stimulation sequences provided in CIs are affected by the noise in the following three manners. First of all, the natural gaps in the speech are filled, which distorts the low-frequency ON/OFF modulations of the speech signal. Secondly, speech envelopes are distorted to include modulations of both speech and noise. Lastly, the N-of-M type of speech coding strategies may select the noise dominated channels instead of the dominant speech...
Source: Hearing Research - February 7, 2013 Category: Audiology Authors: Qazi OU, van Dijk B, Moonen M, Wouters J Tags: Hear Res Source Type: research
Developmental Origin and Fate of Middle Ear Structures.
Abstract Results from developmental and phylogenetic studies have converged to facilitate insight into two important steps in vertebrate evolution: (1) the ontogenetic origin of articulating elements of the buccal skeleton, i.e. jaws, and (2) the later origins of middle ear impedance-matching systems that convey air-borne sound to the inner ear fluids. Middle ear ossicles and other skeletal elements of the viscerocranium (i.e. gill suspensory arches and jaw bones) share a common origin both phylogenetically and ontogenetically. The intention of this brief overview of middle-ear development is to emphasize the inti...
Source: Hearing Research - February 7, 2013 Category: Audiology Authors: Sienknecht UJ Tags: Hear Res Source Type: research
Temporal interaction in electrical hearing elucidates auditory nerve dynamics in humans.
In this study we have developed a double-pulse method and, for the ﬁrst time, reversed stimulus polarity systematically between consecutive pulses to elucidate subthreshold-induced temporal interaction effects. This method allowed us to determine the time-course of subthreshold temporal interaction in human subjects which identifies the limits of encoded temporal precision. Our results show signiﬁcant temporal interaction up to 600 μs inter pulse interval. In all the cases tested we saw a facilitation effect on threshold. Interaction effects at a 20% below threshold pre-conditioning stimulation showed up to 38% &plu...
Source: Hearing Research - February 7, 2013 Category: Audiology Authors: Karg SA, Lackner C, Hemmert W Tags: Hear Res Source Type: research
Relations between cochlear histopathology and hearing loss in experimental cochlear implantation.
This study reviews the cochlear histology from four hearing preservation cochlear implantation experiments conducted on 73 guinea pigs from our institution, and relates histopathological findings to residual hearing. All guinea pigs had normal hearing prior to surgery and underwent cochlear implantation via a cochleostomy with a silastic-platinum dummy electrode. Pure tone auditory brainstem response (ABR) thresholds from 2 to 32 kHz were recorded prior to surgery, and at one and four weeks postoperatively. The cochleae were then fixed in paraformaldehyde, decalcified, paraffin embedded, and mid-modiolar sections were...
Source: Hearing Research - February 5, 2013 Category: Audiology Authors: O'Leary SJ, Monksfield P, Kel G, Connolly T, Souter MA, Chang A, Marovic P, O'Leary JS, Richardson R, Eastwood H Tags: Hear Res Source Type: research
Temporal and spatial distribution of gentamicin in the peripheral vestibular system after transtympanic administration in guinea pigs.
CONCLUSION: The saccular uptake of GTTR is greater than other vestibular end-organs after transtympanic injection. In the semi-circular canals. PMID: 23380663 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - February 1, 2013 Category: Audiology Authors: Zhang R, Zhang YB, Dai CF, Steyger PS Tags: Hear Res Source Type: research
Effect of acoustic similarity on short-term auditory memory in the monkey.
Abstract Recent evidence suggests that the monkey's short-term memory in audition depends on a passively retained sensory trace as opposed to a trace reactivated from long-term memory for use in working memory. Reliance on a passive sensory trace could render memory particularly susceptible to confusion between sounds that are similar in some acoustic dimension. If so, then in delayed matching-to-sample, the monkey's performance should be predicted by the similarity in the salient acoustic dimension between the sample and subsequent test stimulus, even at very short delays. To test this prediction and isolate the ...
Source: Hearing Research - January 31, 2013 Category: Audiology Authors: Scott BH, Mishkin M, Yin P Tags: Hear Res Source Type: research
The perceptual enhancement of tones by frequency shifts.
We report here an experiment in which IE and FE were measured using a task requiring the listener to indicate whether or not the second chord included a tone identical to a subsequent probe tone. The results showed that a global attenuation of the first chord relative to the second chord disrupted IE more than FE. This suggests that the mechanisms of IE and FE are not the same. In accordance with this suggestion, computations of the auditory excitation patterns produced by the chords indicate that the mechanism of IE is not sufficient to explain FE for small frequency shifts. PMID: 23376551 [PubMed - as supplied by pu...
Source: Hearing Research - January 31, 2013 Category: Audiology Authors: Demany L, Carcagno S, Semal C Tags: Hear Res Source Type: research
Effects of sensorineural hearing loss on temporal coding of narrowband and broadband signals in the auditory periphery.
This article is part of a Special Issue entitled "Annual Reviews 2013". PMID: 23376018 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - January 29, 2013 Category: Audiology Authors: Henry KS, Heinz MG Tags: Hear Res Source Type: research
Prospects for replacement of auditory neurons by stem cells.
This article is part of a Special Issue entitled "Inner Ear Development and Regeneration". PMID: 23370457 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - January 28, 2013 Category: Audiology Authors: Shi F, Edge AS Tags: Hear Res Source Type: research
Spiral ganglion cell morphology in guinea pigs after deafening and neurotrophic treatment.
Abstract It is well known that spiral ganglion cells (SGCs) degenerate in hair-cell-depleted cochleas and that treatment with exogenous neurotrophins can prevent this degeneration. Several studies reported that, in addition, SGC size decreases after deafening and increases after neurotrophic treatment. The dynamics of these cell size changes are not well known. In a first experiment we measured size, shape (circularity) and intracellular density of SGCs in guinea pigs at various moments after deafening (1, 2, 4, 6, and 8 weeks) and at various cochlear locations. In a second experiment, the effect of treatment with...
Source: Hearing Research - January 26, 2013 Category: Audiology Authors: van Loon MC, Ramekers D, Agterberg MJ, de Groot JC, Grolman W, Klis SF, Versnel H Tags: Hear Res Source Type: research
The mitochondrion: A perpetrator of acquired hearing loss.
This article is part of a Special Issue entitled "Annual Reviews 2013". PMID: 23361190 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - January 26, 2013 Category: Audiology Authors: Böttger EC, Schacht J Tags: Hear Res Source Type: research
Motor Circuits Help Encode Auditory Memories of Vocal Models used to Guide Vocal Learning.
Abstract Early auditory experience can leave a lasting imprint on brain and behavior. This lasting imprint is most notably manifested in culturally transmitted vocal behaviors, including speech and birdsong, where a vocal model heard early in postnatal life exerts a lifelong influence on the individual's vocal repertoire. Because auditory experience of the vocal model can precede accurate vocal imitation by months or even years, a longstanding idea is that a memory of the model is initially stored in auditory centers, and accessed by vocal motor circuits only later in development. This review considers recent evid...
Source: Hearing Research - January 23, 2013 Category: Audiology Authors: Roberts TF, Mooney R Tags: Hear Res Source Type: research
Eustachian tube pressure equilibration. Temporal analysis of pressure changes based on direct physiological recordings with an intact tympanic membrane.
This study employed direct measurements of middle ear pressure in patients, who after parotidectomy had a catheter inserted into the mastoid with a pressure transducer connected. Thus, monitoring of the middle ear pressure in response to experimentally induced pressure changes could be performed under physiological conditions with an intact tympanic membrane. A set of six experiments was performed in four healthy subjects with different pressure deviations, where the counter-regulation was recorded over 10 min's time frames; a total of 75 events of tube openings were recorded. The transducer had a high accuracy of ±...
Source: Hearing Research - January 21, 2013 Category: Audiology Authors: Gaihede M, Padurariu S, Jacobsen H, De Greef D, Dirckx JJ Tags: Hear Res Source Type: research
Rapid measurement of auditory filter shape in mice using the auditory brainstem response and notched noise.
Abstract The notched noise method is an effective procedure for measuring frequency resolution and auditory filter shapes in both human and animal models of hearing. Briefly, auditory filter shape and bandwidth estimates are derived from masked thresholds for tones presented in noise containing widening spectral notches. As the spectral notch widens, increasingly less of the noise falls within the auditory filter and the tone becomes more detectible until the notch width exceeds the filter bandwidth. Behavioral procedures have been used for the derivation of notched noise auditory filter shapes in mice; however, t...
Source: Hearing Research - January 21, 2013 Category: Audiology Authors: Lina IA, Lauer AM Tags: Hear Res Source Type: research
Lead roles for supporting actors: Critical functions of inner ear supporting cells.
Abstract Many studies that aim to investigate the underlying mechanisms of hearing loss or balance disorders focus on the hair cells and spiral ganglion neurons of the inner ear. Fewer studies have examined the supporting cells that contact both of these cell types in the cochlea and vestibular end organs. While the roles of supporting cells are still being elucidated, emerging evidence indicates that they serve many functions vital to maintaining healthy populations of hair cells and spiral ganglion neurons. Here we review recent studies that highlight the critical roles supporting cells play in the development, ...
Source: Hearing Research - January 21, 2013 Category: Audiology Authors: Monzack EL, Cunningham LL Tags: Hear Res Source Type: research
Response properties underlying selectivity for the rate of frequency modulated sweeps in the auditory cortex of the mouse.
This study focused on the response properties underlying selectivity for the rate of frequency modulated (FM) sweeps in the auditory cortex of anesthetized C57bl/6 (C57) mice. Linear downward FM sweeps with rates between 0.08-20 kHz/msec were tested. We show that at least two different response properties predict FM rate selectivity: sideband inhibition and duration tuning. Sideband inhibition was determined using the two-tone inhibition paradigm in which excitatory and inhibitory tones were presented with different delays. Sideband inhibition was present in the majority (88%, n=53) of neurons. The spectrotemporal properti...
Source: Hearing Research - January 19, 2013 Category: Audiology Authors: Trujillo M, Carrasco MM, Razak K Tags: Hear Res Source Type: research
Progressive hereditary hearing impairment caused by a MYO6 mutation resembles presbyacusis.
Abstract Since deafness is the most common sensorineural disorder in humans, better understanding of the underlying causes is necessary to improve counseling and rehabilitation. A Dutch family with autosomal dominantly inherited sensorineural hearing loss was clinically and genetically assessed. The MYO6 gene was selected to be sequenced because of similarities with other, previously described DFNA22 phenotypes and a pathogenic c.3610C>T (p.R1204W) mutation was found to co-segregate with the disease. This missense mutation results in a flat configured audiogram with a mild hearing loss, which becomes severe to ...
Source: Hearing Research - January 19, 2013 Category: Audiology Authors: Oonk AM, Leijendeckers JM, Lammers EM, Weegerink NJ, Oostrik J, Beynon AJ, Huygen PL, Kunst HP, Kremer H, Snik AF, Pennings RJ Tags: Hear Res Source Type: research
Optimal Ossicular Site for Maximal Vibration Transmissions to Coupled Transducers.
In this study, vibrational responses at seven locations on the middle-ear ossicles (i.e., the malleus head, 4 different points on the incus body, middle of the incus long process, tip of the incus long process) in human temporal bones (n=6) were measured using a laser Doppler vibrometer. The measurements were repeated after separating the incudostapedial joint (ISJ). Measured displacement at each location was normalized with the sound pressure level near the tympanic membrane (TM) for representation in the form of a displacement transfer function (DTF). The normalized squared sum of the DTFs (NSSDTF) was then calculated as...
Source: Hearing Research - January 18, 2013 Category: Audiology Authors: Chung J, Song WJ, Sim JH, Kim W, Oh SH Tags: Hear Res Source Type: research
A historical to present-day account of efforts to answer the question, "what puts the brakes on mammalian hair cell regeneration?"
A historical to present-day account of efforts to answer the question, "what puts the brakes on mammalian hair cell regeneration?" Hear Res. 2013 Jan 17; Authors: Burns JC, Corwin JT Abstract Hearing and balance deficits often affect humans and other mammals permanently, because their ears stop producing hair cells within a few days after birth. But production occurs throughout life in the ears of sharks, bony fish, amphibians, reptiles, and birds allowing them to replace lost hair cells and quickly recover after temporarily experiencing the kinds of sensory deficits that are irreversible for mam...
Source: Hearing Research - January 17, 2013 Category: Audiology Authors: Burns JC, Corwin JT Tags: Hear Res Source Type: research
Detection of acoustic temporal fine structure by cochlear implant listeners: Behavioral results and computational modeling.
Abstract A test of within-channel detection of acoustic temporal fine structure (aTFS) cues is presented. Eight cochlear implant listeners (CI) were asked to discriminate between two Schroeder-phase (SP) complexes using a two-alternative, forced-choice task. Because differences between the acoustic stimuli are primarily constrained to their aTFS, successful discrimination reflects a combination of the subjects' perception of and the strategy's ability to deliver aTFS cues. Subjects were mapped with single-channel Continuous Interleaved Sampling (CIS) and Simultaneous Analog Stimulation (SAS) strategies. To compare...
Source: Hearing Research - January 17, 2013 Category: Audiology Authors: Imennov NS, Won JH, Drennan WR, Jameyson E, Rubinstein JT Tags: Hear Res Source Type: research
Dynamic properties of round window membrane in guinea pig otitis media model measured with electromagnetic stimulation.
Abstract The round window, one of two openings into the cochlea from the middle ear, plays an important role in hearing and is known to be structurally altered during otitis media. However, there have been no published studies systematically describing the changes in biomechanical properties of the round window membrane (RWM) that accompany bacterial otitis media. Here we describe the occurrence of significant changes in the dynamic properties of the RWM between normal guinea pigs and those with acute otitis media (AOM) that are detectable by electromagnetic force stimulation and laser Doppler vibrometry (LDV) mea...
Source: Hearing Research - January 16, 2013 Category: Audiology Authors: Gan RZ, Nakmali D, Zhang X Tags: Hear Res Source Type: research
A brief history of hair cell regeneration research and speculations on the future.
This article is part of a Special Issue entitled "Inner Ear Development and Regeneration". PMID: 23321648 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - January 12, 2013 Category: Audiology Authors: Rubel EW, Furrer SA, Stone JS Tags: Hear Res Source Type: research
Masking patterns for monopolar and phantom electrode stimulation in cochlear implants.
Abstract Phantom electrode (PE) stimulation consists of out-of-phase stimulation of two electrodes. When presented at the apex of the electrode array, phantom stimulation is known to produce a lower pitch sensation than monopolar (MP) stimulation on the most apical electrode. The ratio of the current between the primary electrode (PEL) and the compensating electrode (CEL) is represented by the coefficient σ, which ranges from 0 (monopolar) to 1 (full bipolar). The exact mechanism by which PE stimulation produces a lower pitch sensation is unclear. In the present study, unmasked and masked thresholds were obt...
Source: Hearing Research - January 5, 2013 Category: Audiology Authors: Saoji AA, Landsberger DM, Padilla M, Litvak LM Tags: Hear Res Source Type: research
Pulmonary delivery of d-methionine is associated with an increase in ALCAR and glutathione in cochlear fluids.
This report also demonstrates the validity of the pulmonary administration of antioxidants and highlights the different contributions of d-met and ALCAR allowing to further investigate their impact on oxidative stress in the cochlear microenvironment. PMID: 23296212 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - January 4, 2013 Category: Audiology Authors: Grondin Y, Cotanche DA, Manneberg O, Molina R, Treviño-Villarreal JH, Sepulveda R, Clifford R, Bortoni ME, Forsberg S, Labrecque B, Altshul L, Brain JD, Jackson RL, Rogers RA Tags: Hear Res Source Type: research
Perspective of functional magnetic resonance imaging in middle ear research.
Abstract Functional magnetic resonance imaging (MRI) studies have frequently been applied to study sensory system such as vision, language, and cognition, but have proceeded at a considerably slower speed in investigating middle ear and central auditory processing. This is due to several factors, including the intrinsic anatomy of the middle ear system and inherent acoustic noise during acquisition of MRI data. However, accumulating evidences have demonstrated that clarification of some fundamental neural underpinnings of audition associated with middle ear mechanics can be achieved using functional MRI metho...
Source: Hearing Research - January 2, 2013 Category: Audiology Authors: Chang Y, Lee SH Tags: Hear Res Source Type: research
Standardized tinnitus-specific individual cognitive-behavioral therapy: A controlled outcome study with 286 tinnitus patients.
Abstract BACKGROUND: Pharmacological treatment of tinnitus cannot be considered well established. Thus, reducing tinnitus severity through behavioral therapy is emerging as a key goal. METHODS: A total of 286 patients suffering from persistent and stable tinnitus for four months or longer participated in this controlled clinical multicenter study. The study investigated the efficacy and safety of a standardized treatment involving individual cognitive-behavioral therapy (CBT). Controls were 120 patients waiting to be treated. Therapy was standardized using manualized procedures within the setting of a specifically...
Source: Hearing Research - December 31, 2012 Category: Audiology Authors: Zenner HP, Vonthein R, Zenner B, Leuchtweis R, Plontke SK, Torka W, Pogge S, Birbaumer N Tags: Hear Res Source Type: research
Special Issue on Inner Ear Development and Regeneration.
PMID: 23276729 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - December 28, 2012 Category: Audiology Authors: Heller S Tags: Hear Res Source Type: research
Development of Hyperactivity after Acoustic Trauma in the Guinea Pig Inferior Colliculus.
Abstract The time of onset of hyperactivity (increased spontaneous firing rates) was investigated by single neuron recording in the inferior colliculus (IC) of guinea pigs subjected to unilateral acoustic trauma (exposure to a loud 10kHz tone). Hyperactivity was present by 12hrs post acoustic trauma whereas data obtained within approximately 4hrs of the cessation of acoustic trauma found no evidence of hyperactivity. These data suggest that hyperactivity in the IC begins at some time between 4 and 12hrs post trauma and is a relatively rapid plastic event beginning within hours rather than days post cochlear trauma...
Source: Hearing Research - December 28, 2012 Category: Audiology Authors: Mulders WH, Robertson D Tags: Hear Res Source Type: research
The Effect of Static Force on Round Window Stimulation with the Direct Acoustic Cochlea Stimulator.
Abstract The Direct Acoustic Cochlea Stimulator Partial Implant (DACS PI, Phonak Acoustic Implants SA, Switzerland) is intended to stimulate the cochlea by a conventional stapedotomy piston that is crimped onto the DACS PI artificial incus. An alternative approach to the round window (RW) is successfully done with other devices, having the advantage of being also independent of the existence of middle ear structure (e.g. ossicles). Here the possibility of stimulating the RW with the DACS actuator is investigated including the impact of static force on sound transmission to the cochlea. The maximum equivalent sound...
Source: Hearing Research - December 28, 2012 Category: Audiology Authors: Maier H, Salcher R, Schwab B, Lenarz T Tags: Hear Res Source Type: research
Finite Element Modeling of Energy Absorbance in Normal and Disordered Human Ears.
In this study, a FE model of the human ear, including the ear canal, the middle ear and the spiral cochlea constructed from the histological sections of a human temporal bone, was used to calculate EA. The viscoelastic material properties were applied to the middle ear soft tissues. Three middle ear disorders were simulated in the FE model: otitis media, otosclerosis, and ossicular chain disarticulation. Multi-physics (acoustic, structure, and fluid) coupled analysis was conducted in the model. The FE model was first validated with the published experimental data on the middle ear input impedance and EA of the normal ear. ...
Source: Hearing Research - December 27, 2012 Category: Audiology Authors: Zhang X, Gan RZ Tags: Hear Res Source Type: research
Changes in cochlear function during acute endolymphatic hydrops development in guinea pigs.
Abstract Previous studies have injected artificial endolymph into scala media in anaesthetized guinea pigs as an acute model of endolymphatic hydrops. Here, we have injected artificial endolymph into scala media in guinea pigs at rates of 40-80 nl/min, whilst monitoring Compound Action Potential (CAP) thresholds, the Summating Potential (SP)/CAP ratio, Cochlear Microphonic (CM) distortion, low-frequency modulated Distortion Product Otoacoustic Emissions (DPOAEs), and the Endocochlear Potential (EP). We found that abrupt recovery of CAP thresholds, SP/CAP ratio, and CM and DPOAE asymmetric distortion could occ...
Source: Hearing Research - December 25, 2012 Category: Audiology Authors: Brown DJ, Chihara Y, Curthoys IS, Wang Y, Bos M Tags: Hear Res Source Type: research
Modelling detection thresholds for sounds repeated at different delays.
This study shows that a simple probabilistic model based on Neubauer and Heil (2008) predicts the increase in threshold for short temporal delays as well as the asymptotic behaviour towards longer delays. The model entails (i) a 4th-order gammatone filter with a brief impulse response and thus broad bandwidth (shorter and broader than those of a filter normally assumed), (ii) the formation of stochastic 'spikes' or 'events' whose probability of occurrence is proportional to the filter output (half-wave rectified fine-structure or amplitude envelope), raised to a power of 3, and (iii) probability summation. The same model w...
Source: Hearing Research - December 23, 2012 Category: Audiology Authors: Heil P, Verhey JL, Zoefel B Tags: Hear Res Source Type: research