Proof of concept of intracochlear drug administration by laser-assisted bioprinting in mice
Hear Res. 2023 Aug 29;438:108880. doi: 10.1016/j.heares.2023.108880. Online ahead of print.ABSTRACTTranstympanic administration is used clinically for the injection of gentamicin and/or corticosteroids. This atraumatic route is based on passive diffusion through the round window membrane (RWM). The main limitation of this method is related to the clearance through the Eustachian tube, making the concentration of the therapeutic agent at the intracochlear level uncertain and limited. Moreover, this technique remains unsuitable for molecules of high molecular weight or in the case of gene therapies. The purpose was to study ...
Source: Hearing Research - September 4, 2023 Category: Audiology Authors: Manon Jaffredo Oc éane Duchamp Nicolas Touya Yohan Bouleau Didier Dulon Raphael Devillard Damien Bonnard Source Type: research
Proof of concept of intracochlear drug administration by laser-assisted bioprinting in mice
Hear Res. 2023 Aug 29;438:108880. doi: 10.1016/j.heares.2023.108880. Online ahead of print.ABSTRACTTranstympanic administration is used clinically for the injection of gentamicin and/or corticosteroids. This atraumatic route is based on passive diffusion through the round window membrane (RWM). The main limitation of this method is related to the clearance through the Eustachian tube, making the concentration of the therapeutic agent at the intracochlear level uncertain and limited. Moreover, this technique remains unsuitable for molecules of high molecular weight or in the case of gene therapies. The purpose was to study ...
Source: Hearing Research - September 4, 2023 Category: Audiology Authors: Manon Jaffredo Oc éane Duchamp Nicolas Touya Yohan Bouleau Didier Dulon Raphael Devillard Damien Bonnard Source Type: research
Proof of concept of intracochlear drug administration by laser-assisted bioprinting in mice
Hear Res. 2023 Aug 29;438:108880. doi: 10.1016/j.heares.2023.108880. Online ahead of print.ABSTRACTTranstympanic administration is used clinically for the injection of gentamicin and/or corticosteroids. This atraumatic route is based on passive diffusion through the round window membrane (RWM). The main limitation of this method is related to the clearance through the Eustachian tube, making the concentration of the therapeutic agent at the intracochlear level uncertain and limited. Moreover, this technique remains unsuitable for molecules of high molecular weight or in the case of gene therapies. The purpose was to study ...
Source: Hearing Research - September 4, 2023 Category: Audiology Authors: Manon Jaffredo Oc éane Duchamp Nicolas Touya Yohan Bouleau Didier Dulon Raphael Devillard Damien Bonnard Source Type: research
Learning induces unique transcriptional landscapes in the auditory cortex
Hear Res. 2023 Aug 26;438:108878. doi: 10.1016/j.heares.2023.108878. Online ahead of print.ABSTRACTLearning can induce neurophysiological plasticity in the auditory cortex at multiple timescales. Lasting changes to auditory cortical function that persist over days, weeks, or even a lifetime, require learning to induce de novo gene expression. Indeed, transcription is the molecular determinant for long-term memories to form with a lasting impact on sound-related behavior. However, auditory cortical genes that support auditory learning, memory, and acquired sound-specific behavior are largely unknown. Using an animal model o...
Source: Hearing Research - September 2, 2023 Category: Audiology Authors: G Graham M S Chimenti K L Knudtson D N Grenard L Co M Sumner T Tchou K M Bieszczad Source Type: research
Learning induces unique transcriptional landscapes in the auditory cortex
Hear Res. 2023 Aug 26;438:108878. doi: 10.1016/j.heares.2023.108878. Online ahead of print.ABSTRACTLearning can induce neurophysiological plasticity in the auditory cortex at multiple timescales. Lasting changes to auditory cortical function that persist over days, weeks, or even a lifetime, require learning to induce de novo gene expression. Indeed, transcription is the molecular determinant for long-term memories to form with a lasting impact on sound-related behavior. However, auditory cortical genes that support auditory learning, memory, and acquired sound-specific behavior are largely unknown. Using an animal model o...
Source: Hearing Research - September 2, 2023 Category: Audiology Authors: G Graham M S Chimenti K L Knudtson D N Grenard L Co M Sumner T Tchou K M Bieszczad Source Type: research
Research advances in cochlear pericytes and hearing loss
Hear Res. 2023 Aug 19;438:108877. doi: 10.1016/j.heares.2023.108877. Online ahead of print.ABSTRACTPericytes are specialized mural cells surrounding endothelial cells in microvascular beds. They play a role in vascular development, blood flow regulation, maintenance of blood-tissue barrier integrity, and control of angiogenesis, tissue fibrosis, and wound healing. In recent decades, understanding of the critical role played by pericytes in retina, brain, lung, and kidney has seen significant progress. The cochlea contains a large population of pericytes. However, the role of cochlear pericytes in auditory pathophysiology i...
Source: Hearing Research - August 31, 2023 Category: Audiology Authors: Xiaorui Shi Source Type: research
Research advances in cochlear pericytes and hearing loss
Hear Res. 2023 Aug 19;438:108877. doi: 10.1016/j.heares.2023.108877. Online ahead of print.ABSTRACTPericytes are specialized mural cells surrounding endothelial cells in microvascular beds. They play a role in vascular development, blood flow regulation, maintenance of blood-tissue barrier integrity, and control of angiogenesis, tissue fibrosis, and wound healing. In recent decades, understanding of the critical role played by pericytes in retina, brain, lung, and kidney has seen significant progress. The cochlea contains a large population of pericytes. However, the role of cochlear pericytes in auditory pathophysiology i...
Source: Hearing Research - August 31, 2023 Category: Audiology Authors: Xiaorui Shi Source Type: research
Research advances in cochlear pericytes and hearing loss
Hear Res. 2023 Aug 19;438:108877. doi: 10.1016/j.heares.2023.108877. Online ahead of print.ABSTRACTPericytes are specialized mural cells surrounding endothelial cells in microvascular beds. They play a role in vascular development, blood flow regulation, maintenance of blood-tissue barrier integrity, and control of angiogenesis, tissue fibrosis, and wound healing. In recent decades, understanding of the critical role played by pericytes in retina, brain, lung, and kidney has seen significant progress. The cochlea contains a large population of pericytes. However, the role of cochlear pericytes in auditory pathophysiology i...
Source: Hearing Research - August 31, 2023 Category: Audiology Authors: Xiaorui Shi Source Type: research
Cross-modal implicit learning of random time patterns
Hear Res. 2023 Jul 21;438:108857. doi: 10.1016/j.heares.2023.108857. Online ahead of print.ABSTRACTPerception is sensitive to statistical regularities in the environment, including temporal characteristics of sensory inputs. Interestingly, implicit learning of temporal patterns in one modality can also improve their processing in another modality. However, it is unclear how cross-modal learning transfer affects neural responses to sensory stimuli. Here, we recorded neural activity of human volunteers using electroencephalography (EEG), while participants were exposed to brief sequences of randomly timed auditory or visual ...
Source: Hearing Research - August 28, 2023 Category: Audiology Authors: HiJee Kang Ryszard Auksztulewicz Chi Hong Chan Drew Cappotto Vani G Rajendran Jan W H Schnupp Source Type: research
Cross-modal implicit learning of random time patterns
Hear Res. 2023 Jul 21;438:108857. doi: 10.1016/j.heares.2023.108857. Online ahead of print.ABSTRACTPerception is sensitive to statistical regularities in the environment, including temporal characteristics of sensory inputs. Interestingly, implicit learning of temporal patterns in one modality can also improve their processing in another modality. However, it is unclear how cross-modal learning transfer affects neural responses to sensory stimuli. Here, we recorded neural activity of human volunteers using electroencephalography (EEG), while participants were exposed to brief sequences of randomly timed auditory or visual ...
Source: Hearing Research - August 28, 2023 Category: Audiology Authors: HiJee Kang Ryszard Auksztulewicz Chi Hong Chan Drew Cappotto Vani G Rajendran Jan W H Schnupp Source Type: research
Cross-modal implicit learning of random time patterns
Hear Res. 2023 Jul 21;438:108857. doi: 10.1016/j.heares.2023.108857. Online ahead of print.ABSTRACTPerception is sensitive to statistical regularities in the environment, including temporal characteristics of sensory inputs. Interestingly, implicit learning of temporal patterns in one modality can also improve their processing in another modality. However, it is unclear how cross-modal learning transfer affects neural responses to sensory stimuli. Here, we recorded neural activity of human volunteers using electroencephalography (EEG), while participants were exposed to brief sequences of randomly timed auditory or visual ...
Source: Hearing Research - August 28, 2023 Category: Audiology Authors: HiJee Kang Ryszard Auksztulewicz Chi Hong Chan Drew Cappotto Vani G Rajendran Jan W H Schnupp Source Type: research
Potential roles for lncRNA Mirg/Foxp1 in an ARHL model created using C57BL/6J mice
In conclusion, our findings suggest that lncRNA Mirg expression correlates with cell apoptosis-associated mRNAs in the ARHL model created using C57BL/6 J mice and that oxidative stress-induced lncRNA Mirg promotes HEI-OC1 cell apoptosis by increasing Foxp1 expression. These data suggest the potential therapeutic significance of targeting lncRNA Mirg/Foxp1 signaling in ARHL.PMID:37579646 | DOI:10.1016/j.heares.2023.108859 (Source: Hearing Research)
Source: Hearing Research - August 14, 2023 Category: Audiology Authors: Xiaoqin Luo Yaqin Hu Xiaoqing Zhou Chanyuan Zhang Menglong Feng Ting Yang Wei Yuan Source Type: research
Potential roles for lncRNA Mirg/Foxp1 in an ARHL model created using C57BL/6J mice
In conclusion, our findings suggest that lncRNA Mirg expression correlates with cell apoptosis-associated mRNAs in the ARHL model created using C57BL/6 J mice and that oxidative stress-induced lncRNA Mirg promotes HEI-OC1 cell apoptosis by increasing Foxp1 expression. These data suggest the potential therapeutic significance of targeting lncRNA Mirg/Foxp1 signaling in ARHL.PMID:37579646 | DOI:10.1016/j.heares.2023.108859 (Source: Hearing Research)
Source: Hearing Research - August 14, 2023 Category: Audiology Authors: Xiaoqin Luo Yaqin Hu Xiaoqing Zhou Chanyuan Zhang Menglong Feng Ting Yang Wei Yuan Source Type: research
Potential roles for lncRNA Mirg/Foxp1 in an ARHL model created using C57BL/6J mice
In conclusion, our findings suggest that lncRNA Mirg expression correlates with cell apoptosis-associated mRNAs in the ARHL model created using C57BL/6 J mice and that oxidative stress-induced lncRNA Mirg promotes HEI-OC1 cell apoptosis by increasing Foxp1 expression. These data suggest the potential therapeutic significance of targeting lncRNA Mirg/Foxp1 signaling in ARHL.PMID:37579646 | DOI:10.1016/j.heares.2023.108859 (Source: Hearing Research)
Source: Hearing Research - August 14, 2023 Category: Audiology Authors: Xiaoqin Luo Yaqin Hu Xiaoqing Zhou Chanyuan Zhang Menglong Feng Ting Yang Wei Yuan Source Type: research
Potential roles for lncRNA Mirg/Foxp1 in an ARHL model created using C57BL/6J mice
In conclusion, our findings suggest that lncRNA Mirg expression correlates with cell apoptosis-associated mRNAs in the ARHL model created using C57BL/6 J mice and that oxidative stress-induced lncRNA Mirg promotes HEI-OC1 cell apoptosis by increasing Foxp1 expression. These data suggest the potential therapeutic significance of targeting lncRNA Mirg/Foxp1 signaling in ARHL.PMID:37579646 | DOI:10.1016/j.heares.2023.108859 (Source: Hearing Research)
Source: Hearing Research - August 14, 2023 Category: Audiology Authors: Xiaoqin Luo Yaqin Hu Xiaoqing Zhou Chanyuan Zhang Menglong Feng Ting Yang Wei Yuan Source Type: research
