A spectro-temporal modulation test for predicting speech reception in hearing-impaired listeners with hearing aids
Hear Res. 2024 Jan 4;443:108949. doi: 10.1016/j.heares.2024.108949. Online ahead of print.ABSTRACTSpectro-temporal modulation (STM) detection sensitivity has been shown to be associated with speech-in-noise reception in hearing-impaired (HI) individuals. Based on previous research, a recent study [Zaar, Simonsen, Dau, and Laugesen (2023). Hear Res 427:108650] introduced an STM test paradigm with audibility compensation, employing STM stimulus variants using noise and complex tones as carrier signals. The study demonstrated that the test was suitable for the target population of elderly individuals with moderate-to-severe h...
Source: Hearing Research - January 28, 2024 Category: Audiology Authors: Johannes Zaar Lisbeth Birkelund Simonsen S øren Laugesen Source Type: research
Regional differences in cochlear nonlinearity across the basal organ of Corti of gerbil: Regional differences in cochlear nonlinearity
Hear Res. 2024 Jan 12;443:108951. doi: 10.1016/j.heares.2024.108951. Online ahead of print.ABSTRACTAuditory sensation is based in nanoscale vibration of the sensory tissue of the cochlea, the organ of Corti complex (OCC). Motion within the OCC is now observable due to optical coherence tomography. In a previous study (Cooper et al., 2018), the region that includes the electro-motile outer hair cells (OHC) and Deiters cells (DC) was observed to move with larger amplitude than the basilar membrane (BM) and surrounding regions and was termed the "hotspot." In addition to this quantitative distinction, the hotspot moved qualit...
Source: Hearing Research - January 26, 2024 Category: Audiology Authors: C Elliott Strimbu Lauren A Chiriboga Brian L Frost Elizabeth S Olson Source Type: research
Tripolar configuration and pulse shape in cochlear implants reduce channel interactions in the temporal domain
Hear Res. 2024 Jan 19;443:108953. doi: 10.1016/j.heares.2024.108953. Online ahead of print.ABSTRACTThe present study investigates effects of current focusing and pulse shape on threshold, dynamic range, spread of excitation and channel interaction in the time domain using cochlear implant stimulation. The study was performed on 20 adult guinea pigs using a 6-channel animal cochlear implant, recording was performed in the auditory midbrain using a multielectrode array. After determining the best frequencies for individual recording contacts with acoustic stimulation, the ear was deafened and a cochlear implant was inserted ...
Source: Hearing Research - January 26, 2024 Category: Audiology Authors: Gunnar L Quass Andrej Kral Source Type: research
Frequency selectivity in monkey auditory nerve studied with suprathreshold multicomponent stimuli
Hear Res. 2024 Jan 21;443:108964. doi: 10.1016/j.heares.2024.108964. Online ahead of print.ABSTRACTData from non-human primates can help extend observations from non-primate species to humans. Here we report measurements on the auditory nerve of macaque monkeys in the context of a controversial topic important to human hearing. A range of techniques have been used to examine the claim, which is not generally accepted, that human frequency tuning is sharper than traditionally thought, and sharper than in commonly used animal models. Data from single auditory-nerve fibers occupy a pivotal position to examine this claim, but ...
Source: Hearing Research - January 26, 2024 Category: Audiology Authors: P X Joris E Verschooten M Mc Laughlin Cpc Versteegh M van der Heijden Source Type: research
Auditory processing control by the medial prefrontal cortex: A review of the rodent functional organisation
Hear Res. 2024 Jan 20;443:108954. doi: 10.1016/j.heares.2024.108954. Online ahead of print.ABSTRACTAfferent inputs from the cochlea transmit auditory information to the central nervous system, where information is processed and passed up the hierarchy, ending in the auditory cortex. Through these brain pathways, spectral and temporal features of sounds are processed and sent to the cortex for perception. There are also many mechanisms in place for modulation of these inputs, with a major source of modulation being based in the medial prefrontal cortex (mPFC). Neurons of the rodent mPFC receive input from the auditory corte...
Source: Hearing Research - January 25, 2024 Category: Audiology Authors: A Hockley M S Malmierca Source Type: research
Barn owls specialized sound-driven behavior: Lessons in optimal processing and coding by the auditory system
Hear Res. 2024 Jan 15;443:108952. doi: 10.1016/j.heares.2024.108952. Online ahead of print.ABSTRACTThe barn owl, a nocturnal raptor with remarkably efficient prey-capturing abilities, has been one of the initial animal models used for research of brain mechanisms underlying sound localization. Some seminal findings made from their specialized sound localizing auditory system include discoveries of a midbrain map of auditory space, mechanisms towards spatial cue detection underlying sound-driven orienting behavior, and circuit level changes supporting development and experience-dependent plasticity. These findings have expl...
Source: Hearing Research - January 19, 2024 Category: Audiology Authors: Andrea Bae Jose L Pe ña Source Type: research
Time-dependent effects of acoustic trauma and tinnitus on extracellular levels of amino acids in the inferior colliculus of rats
Hear Res. 2024 Jan 3;443:108948. doi: 10.1016/j.heares.2024.108948. Online ahead of print.ABSTRACTChronic tinnitus is a debilitating condition with very few management options. Acoustic trauma that causes tinnitus has been shown to induce neuronal hyperactivity in multiple brain areas in the auditory pathway, including the inferior colliculus. This neuronal hyperactivity could be attributed to an imbalance between excitatory and inhibitory neurotransmission. However, it is not clear how the levels of neurotransmitters, especially neurotransmitters in the extracellular space, change over time following acoustic trauma and t...
Source: Hearing Research - January 14, 2024 Category: Audiology Authors: Huey Tieng Tan Paul F Smith Yiwen Zheng Source Type: research
Pharmacokinetics of monoclonal antibodies locally-applied into the middle ear of guinea pigs
Hear Res. 2024 Feb;442:108950. doi: 10.1016/j.heares.2024.108950. Epub 2024 Jan 8.ABSTRACTCountless therapeutic antibodies are currently available for the treatment of a broad range of diseases. Some target molecules of therapeutic antibodies are involved in the pathogenesis of sensorineural hearing loss (SNHL), suggesting that SNHL may be a novel target for monoclonal antibody (mAb) therapy. When considering mAb therapy for SNHL, understanding of the pharmacokinetics of mAbs after local application into the middle ear is crucial. To reveal the fundamental characteristics of mAb pharmacokinetics following local application...
Source: Hearing Research - January 13, 2024 Category: Audiology Authors: Tomoko Kita Yoshiyuki Yabe Yuki Maruyama Yuki Tachida Yoshitake Furuta Naotoshi Yamamura Ichiro Furuta Kohei Yamahara Masaaki Ishikawa Koichi Omori Taro Yamaguchi Takayuki Nakagawa Source Type: research
Rational design of a genomically humanized mouse model for dominantly inherited hearing loss, DFNA9
Hear Res. 2024 Feb;442:108947. doi: 10.1016/j.heares.2023.108947. Epub 2023 Dec 31.ABSTRACTDFNA9 is a dominantly inherited form of adult-onset progressive hearing impairment caused by mutations in the COCH gene. COCH encodes cochlin, a crucial extracellular matrix protein. We established a genomically humanized mouse model for the Dutch/Belgian c.151C>T founder mutation in COCH. Considering upcoming sequence-specific genetic therapies, we exchanged the genomic murine Coch exons 3-6 for the corresponding human sequence. Introducing human-specific genetic information into mouse exons can be risky. To mitigate unforeseen c...
Source: Hearing Research - January 13, 2024 Category: Audiology Authors: Dorien Verdoodt Erwin van Wijk Sanne Broekman Hanka Venselaar Fien Aben Lize Sels Evi De Backer Hanne Gommeren Krystyna Szewczyk Guy Van Camp Peter Ponsaerts Vincent Van Rompaey Erik de Vrieze Source Type: research
Neural hyperactivity and altered envelope encoding in the central auditory system: Changes with advanced age and hearing loss
Hear Res. 2024 Feb;442:108945. doi: 10.1016/j.heares.2023.108945. Epub 2023 Dec 23.ABSTRACTTemporal modulations are ubiquitous features of sound signals that are important for auditory perception. The perception of temporal modulations, or temporal processing, is known to decline with aging and hearing loss and negatively impact auditory perception in general and speech recognition specifically. However, neurophysiological literature also provides evidence of exaggerated or enhanced encoding of specifically temporal envelopes in aging and hearing loss, which may arise from changes in inhibitory neurotransmission and neuron...
Source: Hearing Research - December 28, 2023 Category: Audiology Authors: Carolyn M McClaskey Source Type: research
Neural hyperactivity and altered envelope encoding in the central auditory system: Changes with advanced age and hearing loss
Hear Res. 2023 Dec 23;442:108945. doi: 10.1016/j.heares.2023.108945. Online ahead of print.ABSTRACTTemporal modulations are ubiquitous features of sound signals that are important for auditory perception. The perception of temporal modulations, or temporal processing, is known to decline with aging and hearing loss and negatively impact auditory perception in general and speech recognition specifically. However, neurophysiological literature also provides evidence of exaggerated or enhanced encoding of specifically temporal envelopes in aging and hearing loss, which may arise from changes in inhibitory neurotransmission an...
Source: Hearing Research - December 28, 2023 Category: Audiology Authors: Carolyn M McClaskey Source Type: research
Neural hyperactivity and altered envelope encoding in the central auditory system: Changes with advanced age and hearing loss
Hear Res. 2023 Dec 23;442:108945. doi: 10.1016/j.heares.2023.108945. Online ahead of print.ABSTRACTTemporal modulations are ubiquitous features of sound signals that are important for auditory perception. The perception of temporal modulations, or temporal processing, is known to decline with aging and hearing loss and negatively impact auditory perception in general and speech recognition specifically. However, neurophysiological literature also provides evidence of exaggerated or enhanced encoding of specifically temporal envelopes in aging and hearing loss, which may arise from changes in inhibitory neurotransmission an...
Source: Hearing Research - December 28, 2023 Category: Audiology Authors: Carolyn M McClaskey Source Type: research
Neural hyperactivity and altered envelope encoding in the central auditory system: Changes with advanced age and hearing loss
Hear Res. 2023 Dec 23;442:108945. doi: 10.1016/j.heares.2023.108945. Online ahead of print.ABSTRACTTemporal modulations are ubiquitous features of sound signals that are important for auditory perception. The perception of temporal modulations, or temporal processing, is known to decline with aging and hearing loss and negatively impact auditory perception in general and speech recognition specifically. However, neurophysiological literature also provides evidence of exaggerated or enhanced encoding of specifically temporal envelopes in aging and hearing loss, which may arise from changes in inhibitory neurotransmission an...
Source: Hearing Research - December 28, 2023 Category: Audiology Authors: Carolyn M McClaskey Source Type: research
Neural hyperactivity and altered envelope encoding in the central auditory system: Changes with advanced age and hearing loss
Hear Res. 2023 Dec 23;442:108945. doi: 10.1016/j.heares.2023.108945. Online ahead of print.ABSTRACTTemporal modulations are ubiquitous features of sound signals that are important for auditory perception. The perception of temporal modulations, or temporal processing, is known to decline with aging and hearing loss and negatively impact auditory perception in general and speech recognition specifically. However, neurophysiological literature also provides evidence of exaggerated or enhanced encoding of specifically temporal envelopes in aging and hearing loss, which may arise from changes in inhibitory neurotransmission an...
Source: Hearing Research - December 28, 2023 Category: Audiology Authors: Carolyn M McClaskey Source Type: research
Neural hyperactivity and altered envelope encoding in the central auditory system: Changes with advanced age and hearing loss
Hear Res. 2023 Dec 23;442:108945. doi: 10.1016/j.heares.2023.108945. Online ahead of print.ABSTRACTTemporal modulations are ubiquitous features of sound signals that are important for auditory perception. The perception of temporal modulations, or temporal processing, is known to decline with aging and hearing loss and negatively impact auditory perception in general and speech recognition specifically. However, neurophysiological literature also provides evidence of exaggerated or enhanced encoding of specifically temporal envelopes in aging and hearing loss, which may arise from changes in inhibitory neurotransmission an...
Source: Hearing Research - December 28, 2023 Category: Audiology Authors: Carolyn M McClaskey Source Type: research
