Behavioral characterization of the cochlear amplifier lesion due to loss of function of stereocilin (STRC) in human subjects
Hear Res. 2023 Nov;439:108898. doi: 10.1016/j.heares.2023.108898. Epub 2023 Oct 20.ABSTRACTLoss of function of stereocilin (STRC) is the second most common cause of inherited hearing loss. The loss of the stereocilin protein, encoded by the STRC gene, induces the loss of connection between outer hair cells and tectorial membrane. This only affects the outer hair cells (OHCs) function, involving deficits of active cochlear frequency selectivity and amplifier functions despite preservation of normal inner hair cells. Better understanding of cochlear features associated with mutation of STRC will improve our knowledge of norm...
Source: Hearing Research - October 27, 2023 Category: Audiology Authors: Charlotte Benoit Ryan J Carlson Mary-Claire King David L Horn Jay T Rubinstein Source Type: research
Behavioral characterization of the cochlear amplifier lesion due to loss of function of stereocilin (STRC) in human subjects
Hear Res. 2023 Oct 20;439:108898. doi: 10.1016/j.heares.2023.108898. Online ahead of print.ABSTRACTLoss of function of stereocilin (STRC) is the second most common cause of inherited hearing loss. The loss of the stereocilin protein, encoded by the STRC gene, induces the loss of connection between outer hair cells and tectorial membrane. This only affects the outer hair cells (OHCs) function, involving deficits of active cochlear frequency selectivity and amplifier functions despite preservation of normal inner hair cells. Better understanding of cochlear features associated with mutation of STRC will improve our knowledge...
Source: Hearing Research - October 27, 2023 Category: Audiology Authors: Charlotte Benoit Ryan J Carlson Mary-Claire King David L Horn Jay T Rubinstein Source Type: research
Behavioral characterization of the cochlear amplifier lesion due to loss of function of stereocilin (STRC) in human subjects
Hear Res. 2023 Oct 20;439:108898. doi: 10.1016/j.heares.2023.108898. Online ahead of print.ABSTRACTLoss of function of stereocilin (STRC) is the second most common cause of inherited hearing loss. The loss of the stereocilin protein, encoded by the STRC gene, induces the loss of connection between outer hair cells and tectorial membrane. This only affects the outer hair cells (OHCs) function, involving deficits of active cochlear frequency selectivity and amplifier functions despite preservation of normal inner hair cells. Better understanding of cochlear features associated with mutation of STRC will improve our knowledge...
Source: Hearing Research - October 27, 2023 Category: Audiology Authors: Charlotte Benoit Ryan J Carlson Mary-Claire King David L Horn Jay T Rubinstein Source Type: research
Behavioral characterization of the cochlear amplifier lesion due to loss of function of stereocilin (STRC) in human subjects
Hear Res. 2023 Oct 20;439:108898. doi: 10.1016/j.heares.2023.108898. Online ahead of print.ABSTRACTLoss of function of stereocilin (STRC) is the second most common cause of inherited hearing loss. The loss of the stereocilin protein, encoded by the STRC gene, induces the loss of connection between outer hair cells and tectorial membrane. This only affects the outer hair cells (OHCs) function, involving deficits of active cochlear frequency selectivity and amplifier functions despite preservation of normal inner hair cells. Better understanding of cochlear features associated with mutation of STRC will improve our knowledge...
Source: Hearing Research - October 27, 2023 Category: Audiology Authors: Charlotte Benoit Ryan J Carlson Mary-Claire King David L Horn Jay T Rubinstein Source Type: research
Behavioral characterization of the cochlear amplifier lesion due to loss of function of stereocilin (STRC) in human subjects
Hear Res. 2023 Oct 20;439:108898. doi: 10.1016/j.heares.2023.108898. Online ahead of print.ABSTRACTLoss of function of stereocilin (STRC) is the second most common cause of inherited hearing loss. The loss of the stereocilin protein, encoded by the STRC gene, induces the loss of connection between outer hair cells and tectorial membrane. This only affects the outer hair cells (OHCs) function, involving deficits of active cochlear frequency selectivity and amplifier functions despite preservation of normal inner hair cells. Better understanding of cochlear features associated with mutation of STRC will improve our knowledge...
Source: Hearing Research - October 27, 2023 Category: Audiology Authors: Charlotte Benoit Ryan J Carlson Mary-Claire King David L Horn Jay T Rubinstein Source Type: research
Behavioral characterization of the cochlear amplifier lesion due to loss of function of stereocilin (STRC) in human subjects
Hear Res. 2023 Oct 20;439:108898. doi: 10.1016/j.heares.2023.108898. Online ahead of print.ABSTRACTLoss of function of stereocilin (STRC) is the second most common cause of inherited hearing loss. The loss of the stereocilin protein, encoded by the STRC gene, induces the loss of connection between outer hair cells and tectorial membrane. This only affects the outer hair cells (OHCs) function, involving deficits of active cochlear frequency selectivity and amplifier functions despite preservation of normal inner hair cells. Better understanding of cochlear features associated with mutation of STRC will improve our knowledge...
Source: Hearing Research - October 27, 2023 Category: Audiology Authors: Charlotte Benoit Ryan J Carlson Mary-Claire King David L Horn Jay T Rubinstein Source Type: research
The effect of motion frequency and sound source frequency on steady-state auditory motion evoked potential
Hear Res. 2023 Oct 13;439:108897. doi: 10.1016/j.heares.2023.108897. Online ahead of print.ABSTRACTThe ability of humans to perceive motion sound sources is important for accurate response to the living environment. Periodic motion sound sources can elicit steady-state motion auditory evoked potential (SSMAEP). The purpose of this study was to investigate the effects of different motion frequencies and different frequencies of sound source on SSMAEP. The stimulation paradigms for simulating periodic motion of sound sources were designed utilizing head-related transfer function (HRTF) techniques in this study. The motion fr...
Source: Hearing Research - October 23, 2023 Category: Audiology Authors: Huanqing Zhang Jun Xie Qing Tao Yi Xiao Guiling Cui Wenhu Fang Xinyu Zhu Guanghua Xu Min Li Chengcheng Han Source Type: research
The effect of motion frequency and sound source frequency on steady-state auditory motion evoked potential
Hear Res. 2023 Oct 13;439:108897. doi: 10.1016/j.heares.2023.108897. Online ahead of print.ABSTRACTThe ability of humans to perceive motion sound sources is important for accurate response to the living environment. Periodic motion sound sources can elicit steady-state motion auditory evoked potential (SSMAEP). The purpose of this study was to investigate the effects of different motion frequencies and different frequencies of sound source on SSMAEP. The stimulation paradigms for simulating periodic motion of sound sources were designed utilizing head-related transfer function (HRTF) techniques in this study. The motion fr...
Source: Hearing Research - October 23, 2023 Category: Audiology Authors: Huanqing Zhang Jun Xie Qing Tao Yi Xiao Guiling Cui Wenhu Fang Xinyu Zhu Guanghua Xu Min Li Chengcheng Han Source Type: research
The effect of motion frequency and sound source frequency on steady-state auditory motion evoked potential
Hear Res. 2023 Oct 13;439:108897. doi: 10.1016/j.heares.2023.108897. Online ahead of print.ABSTRACTThe ability of humans to perceive motion sound sources is important for accurate response to the living environment. Periodic motion sound sources can elicit steady-state motion auditory evoked potential (SSMAEP). The purpose of this study was to investigate the effects of different motion frequencies and different frequencies of sound source on SSMAEP. The stimulation paradigms for simulating periodic motion of sound sources were designed utilizing head-related transfer function (HRTF) techniques in this study. The motion fr...
Source: Hearing Research - October 23, 2023 Category: Audiology Authors: Huanqing Zhang Jun Xie Qing Tao Yi Xiao Guiling Cui Wenhu Fang Xinyu Zhu Guanghua Xu Min Li Chengcheng Han Source Type: research
The effect of motion frequency and sound source frequency on steady-state auditory motion evoked potential
Hear Res. 2023 Oct 13;439:108897. doi: 10.1016/j.heares.2023.108897. Online ahead of print.ABSTRACTThe ability of humans to perceive motion sound sources is important for accurate response to the living environment. Periodic motion sound sources can elicit steady-state motion auditory evoked potential (SSMAEP). The purpose of this study was to investigate the effects of different motion frequencies and different frequencies of sound source on SSMAEP. The stimulation paradigms for simulating periodic motion of sound sources were designed utilizing head-related transfer function (HRTF) techniques in this study. The motion fr...
Source: Hearing Research - October 23, 2023 Category: Audiology Authors: Huanqing Zhang Jun Xie Qing Tao Yi Xiao Guiling Cui Wenhu Fang Xinyu Zhu Guanghua Xu Min Li Chengcheng Han Source Type: research
The effect of motion frequency and sound source frequency on steady-state auditory motion evoked potential
Hear Res. 2023 Oct 13;439:108897. doi: 10.1016/j.heares.2023.108897. Online ahead of print.ABSTRACTThe ability of humans to perceive motion sound sources is important for accurate response to the living environment. Periodic motion sound sources can elicit steady-state motion auditory evoked potential (SSMAEP). The purpose of this study was to investigate the effects of different motion frequencies and different frequencies of sound source on SSMAEP. The stimulation paradigms for simulating periodic motion of sound sources were designed utilizing head-related transfer function (HRTF) techniques in this study. The motion fr...
Source: Hearing Research - October 23, 2023 Category: Audiology Authors: Huanqing Zhang Jun Xie Qing Tao Yi Xiao Guiling Cui Wenhu Fang Xinyu Zhu Guanghua Xu Min Li Chengcheng Han Source Type: research
Genetic analysis of potential biomarkers and therapeutic targets in age-related hearing loss
In conclusion, Clec4n, Mpeg1, and Fcgr3 play essential roles in developing ARHL, and they might become vital targets in ARHL diagnosis and anti-inflammatory therapy.PMID:37844444 | DOI:10.1016/j.heares.2023.108894 (Source: Hearing Research)
Source: Hearing Research - October 16, 2023 Category: Audiology Authors: Yajing Cheng Wenjin Chen Jia Xu Hang Liu Ting Chen Jun Hu Source Type: research
Genetic analysis of potential biomarkers and therapeutic targets in age-related hearing loss
In conclusion, Clec4n, Mpeg1, and Fcgr3 play essential roles in developing ARHL, and they might become vital targets in ARHL diagnosis and anti-inflammatory therapy.PMID:37844444 | DOI:10.1016/j.heares.2023.108894 (Source: Hearing Research)
Source: Hearing Research - October 16, 2023 Category: Audiology Authors: Yajing Cheng Wenjin Chen Jia Xu Hang Liu Ting Chen Jun Hu Source Type: research
Genetic analysis of potential biomarkers and therapeutic targets in age-related hearing loss
In conclusion, Clec4n, Mpeg1, and Fcgr3 play essential roles in developing ARHL, and they might become vital targets in ARHL diagnosis and anti-inflammatory therapy.PMID:37844444 | DOI:10.1016/j.heares.2023.108894 (Source: Hearing Research)
Source: Hearing Research - October 16, 2023 Category: Audiology Authors: Yajing Cheng Wenjin Chen Jia Xu Hang Liu Ting Chen Jun Hu Source Type: research
Genetic analysis of potential biomarkers and therapeutic targets in age-related hearing loss
In conclusion, Clec4n, Mpeg1, and Fcgr3 play essential roles in developing ARHL, and they might become vital targets in ARHL diagnosis and anti-inflammatory therapy.PMID:37844444 | DOI:10.1016/j.heares.2023.108894 (Source: Hearing Research)
Source: Hearing Research - October 16, 2023 Category: Audiology Authors: Yajing Cheng Wenjin Chen Jia Xu Hang Liu Ting Chen Jun Hu Source Type: research
