Audiovisual spatial ventriloquism is reduced in musicians
Hear Res. 2023 Nov 18;440:108918. doi: 10.1016/j.heares.2023.108918. Online ahead of print.ABSTRACTThere is great scientific and public interest in claims that musical training improves general cognitive and perceptual abilities. While this is controversial, recent and rather convincing evidence suggests that musical training refines the temporal integration of auditory and visual stimuli at a general level. We investigated whether musical training also affects integration in the spatial domain, via an auditory localisation experiment that measured ventriloquism (where localisation is biased towards visual stimuli on audio...
Source: Hearing Research - November 22, 2023 Category: Audiology Authors: Matthew O'Donohue Philippe Lacherez Naohide Yamamoto Source Type: research
Sensitivity to direction and velocity of fast frequency chirps in the inferior colliculus of awake rabbit
Hear Res. 2023 Nov 15;440:108915. doi: 10.1016/j.heares.2023.108915. Online ahead of print.ABSTRACTNeurons in the mammalian inferior colliculus (IC) are sensitive to the velocity (speed and direction) of fast frequency chirps contained in Schroeder-phase harmonic complexes (SCHR). However, IC neurons are also sensitive to stimulus periodicity, a prominent feature of SCHR stimuli. Here, to disentangle velocity sensitivity from periodicity tuning, we introduced a novel stimulus consisting of aperiodic random chirps. Extracellular, single-unit recordings were made in the IC of Dutch-belted rabbits in response to both SCHR and...
Source: Hearing Research - November 22, 2023 Category: Audiology Authors: Paul W Mitchell Kenneth S Henry Laurel H Carney Source Type: research
Deficient central mechanisms in tinnitus: Exploring the impact on speech comprehension and executive functions
Hear Res. 2023 Nov 10;440:108914. doi: 10.1016/j.heares.2023.108914. Online ahead of print.ABSTRACTMany individuals with chronic subjective tinnitus report significant problems in comprehending speech in adverse listening situations. A large body of studies has provided evidence to support the notion that deficits in speech-in-noise (SIN) are prevalent in the tinnitus population, while some studies have challenged these findings. Elemental auditory perception is usually only minimally or not impaired. In addition, deficits in cognitive functions, particularly executive functions, have also been observed in individuals with...
Source: Hearing Research - November 18, 2023 Category: Audiology Authors: Nick Sommerhalder Patrick Neff Zbyn ěk Bureš Oliver Profant Tobias Kleinjung Martin Meyer Source Type: research
Individual similarities and differences in eye-movement-related eardrum oscillations (EMREOs)
Hear Res. 2023 Oct 30;440:108899. doi: 10.1016/j.heares.2023.108899. Online ahead of print.ABSTRACTWe recently discovered a unique type of otoacoustic emission (OAE) time-locked to the onset (and offset) of saccadic eye movements and occurring in the absence of external sound (Gruters et al., 2018). How and why these eye-movement-related eardrum oscillations (EMREOs) are generated is unknown, with a role in visual-auditory integration being the likeliest candidate. Clues to both the drivers of EMREOs and their purpose can be gleaned by examining responses in normal hearing human subjects. Do EMREOs occur in all individuals...
Source: Hearing Research - November 18, 2023 Category: Audiology Authors: Cynthia D King Stephanie N Lovich David Lk Murphy Rachel Landrum David Kaylie Christopher A Shera Jennifer M Groh Source Type: research
Deficient central mechanisms in tinnitus: Exploring the impact on speech comprehension and executive functions
Hear Res. 2023 Nov 10;440:108914. doi: 10.1016/j.heares.2023.108914. Online ahead of print.ABSTRACTMany individuals with chronic subjective tinnitus report significant problems in comprehending speech in adverse listening situations. A large body of studies has provided evidence to support the notion that deficits in speech-in-noise (SIN) are prevalent in the tinnitus population, while some studies have challenged these findings. Elemental auditory perception is usually only minimally or not impaired. In addition, deficits in cognitive functions, particularly executive functions, have also been observed in individuals with...
Source: Hearing Research - November 18, 2023 Category: Audiology Authors: Nick Sommerhalder Patrick Neff Zbyn ěk Bureš Oliver Profant Tobias Kleinjung Martin Meyer Source Type: research
Individual similarities and differences in eye-movement-related eardrum oscillations (EMREOs)
Hear Res. 2023 Oct 30;440:108899. doi: 10.1016/j.heares.2023.108899. Online ahead of print.ABSTRACTWe recently discovered a unique type of otoacoustic emission (OAE) time-locked to the onset (and offset) of saccadic eye movements and occurring in the absence of external sound (Gruters et al., 2018). How and why these eye-movement-related eardrum oscillations (EMREOs) are generated is unknown, with a role in visual-auditory integration being the likeliest candidate. Clues to both the drivers of EMREOs and their purpose can be gleaned by examining responses in normal hearing human subjects. Do EMREOs occur in all individuals...
Source: Hearing Research - November 18, 2023 Category: Audiology Authors: Cynthia D King Stephanie N Lovich David Lk Murphy Rachel Landrum David Kaylie Christopher A Shera Jennifer M Groh Source Type: research
Deficient central mechanisms in tinnitus: Exploring the impact on speech comprehension and executive functions
Hear Res. 2023 Nov 10;440:108914. doi: 10.1016/j.heares.2023.108914. Online ahead of print.ABSTRACTMany individuals with chronic subjective tinnitus report significant problems in comprehending speech in adverse listening situations. A large body of studies has provided evidence to support the notion that deficits in speech-in-noise (SIN) are prevalent in the tinnitus population, while some studies have challenged these findings. Elemental auditory perception is usually only minimally or not impaired. In addition, deficits in cognitive functions, particularly executive functions, have also been observed in individuals with...
Source: Hearing Research - November 18, 2023 Category: Audiology Authors: Nick Sommerhalder Patrick Neff Zbyn ěk Bureš Oliver Profant Tobias Kleinjung Martin Meyer Source Type: research
Individual similarities and differences in eye-movement-related eardrum oscillations (EMREOs)
Hear Res. 2023 Oct 30;440:108899. doi: 10.1016/j.heares.2023.108899. Online ahead of print.ABSTRACTWe recently discovered a unique type of otoacoustic emission (OAE) time-locked to the onset (and offset) of saccadic eye movements and occurring in the absence of external sound (Gruters et al., 2018). How and why these eye-movement-related eardrum oscillations (EMREOs) are generated is unknown, with a role in visual-auditory integration being the likeliest candidate. Clues to both the drivers of EMREOs and their purpose can be gleaned by examining responses in normal hearing human subjects. Do EMREOs occur in all individuals...
Source: Hearing Research - November 18, 2023 Category: Audiology Authors: Cynthia D King Stephanie N Lovich David Lk Murphy Rachel Landrum David Kaylie Christopher A Shera Jennifer M Groh Source Type: research
Deficient central mechanisms in tinnitus: Exploring the impact on speech comprehension and executive functions
Hear Res. 2023 Nov 10;440:108914. doi: 10.1016/j.heares.2023.108914. Online ahead of print.ABSTRACTMany individuals with chronic subjective tinnitus report significant problems in comprehending speech in adverse listening situations. A large body of studies has provided evidence to support the notion that deficits in speech-in-noise (SIN) are prevalent in the tinnitus population, while some studies have challenged these findings. Elemental auditory perception is usually only minimally or not impaired. In addition, deficits in cognitive functions, particularly executive functions, have also been observed in individuals with...
Source: Hearing Research - November 18, 2023 Category: Audiology Authors: Nick Sommerhalder Patrick Neff Zbyn ěk Bureš Oliver Profant Tobias Kleinjung Martin Meyer Source Type: research
Individual similarities and differences in eye-movement-related eardrum oscillations (EMREOs)
Hear Res. 2023 Oct 30;440:108899. doi: 10.1016/j.heares.2023.108899. Online ahead of print.ABSTRACTWe recently discovered a unique type of otoacoustic emission (OAE) time-locked to the onset (and offset) of saccadic eye movements and occurring in the absence of external sound (Gruters et al., 2018). How and why these eye-movement-related eardrum oscillations (EMREOs) are generated is unknown, with a role in visual-auditory integration being the likeliest candidate. Clues to both the drivers of EMREOs and their purpose can be gleaned by examining responses in normal hearing human subjects. Do EMREOs occur in all individuals...
Source: Hearing Research - November 18, 2023 Category: Audiology Authors: Cynthia D King Stephanie N Lovich David Lk Murphy Rachel Landrum David Kaylie Christopher A Shera Jennifer M Groh Source Type: research
Spread of activation and interaction between channels with multi-channel optogenetic stimulation in the mouse cochlea
This study compares the spread of neural activity across the inferior colliculus of the auditory midbrain during electrical and optical stimulation in the cochlea of acutely deafened mice with opsin-modified spiral ganglion neurons (H134R variant of the channelrhodopsin-2). Monopolar electrical stimulation was delivered via each of four 0.2 mm wide platinum electrode rings at 0.6 mm centre-to-centre spacing, whereas 453 nm wavelength light was delivered via each of five 0.22 × 0.27 mm micro-light emitting diodes (LEDs) at 0.52 mm centre-to-centre spacing. Channel interactions were also quantified by threshold changes duri...
Source: Hearing Research - November 17, 2023 Category: Audiology Authors: Ajmal A Azees Alex C Thompson Ross Thomas Jenny Zhou Patrick Ruther Andrew K Wise Elise A Ajay David J Garrett Anita Quigley James B Fallon Rachael T Richardson Source Type: research
Spread of activation and interaction between channels with multi-channel optogenetic stimulation in the mouse cochlea
This study compares the spread of neural activity across the inferior colliculus of the auditory midbrain during electrical and optical stimulation in the cochlea of acutely deafened mice with opsin-modified spiral ganglion neurons (H134R variant of the channelrhodopsin-2). Monopolar electrical stimulation was delivered via each of four 0.2 mm wide platinum electrode rings at 0.6 mm centre-to-centre spacing, whereas 453 nm wavelength light was delivered via each of five 0.22 × 0.27 mm micro-light emitting diodes (LEDs) at 0.52 mm centre-to-centre spacing. Channel interactions were also quantified by threshold changes duri...
Source: Hearing Research - November 17, 2023 Category: Audiology Authors: Ajmal A Azees Alex C Thompson Ross Thomas Jenny Zhou Patrick Ruther Andrew K Wise Elise A Ajay David J Garrett Anita Quigley James B Fallon Rachael T Richardson Source Type: research
Susceptibility of immature spiral ganglion neurons to aminoglycoside-induced ototoxicity is mediated by the TRPV1 channel in mice
This study aimed to investigate whether a nonselective cation channel, TRPV1, contributes to the susceptibility of immature spiral ganglion neurons (SGNs) to the damage caused by aminoglycosides. Through western blotting and immunofluorescence, we found that the TRPV1 expression levels were much higher in immature SGNs than in their mature counterparts. In postnatal day 7 cochlear organotypic cultures, AMG-517 reduced reactive oxygen species generation and inhibited SGN apoptosis under aminoglycoside challenge. However, in adult mice, AMG-517 did not ameliorate the ABR threshold increase at high frequencies (16 kHz and 32 ...
Source: Hearing Research - November 13, 2023 Category: Audiology Authors: Yijiang Bai Jing Liu Xuewen Wu Bo Pang Shuai Zhang Mengzhu Jiang Anhai Chen Huping Huang Yongjia Chen Yuan Zeng Lingyun Mei Kelei Gao Source Type: research
Susceptibility of immature spiral ganglion neurons to aminoglycoside-induced ototoxicity is mediated by the TRPV1 channel in mice
This study aimed to investigate whether a nonselective cation channel, TRPV1, contributes to the susceptibility of immature spiral ganglion neurons (SGNs) to the damage caused by aminoglycosides. Through western blotting and immunofluorescence, we found that the TRPV1 expression levels were much higher in immature SGNs than in their mature counterparts. In postnatal day 7 cochlear organotypic cultures, AMG-517 reduced reactive oxygen species generation and inhibited SGN apoptosis under aminoglycoside challenge. However, in adult mice, AMG-517 did not ameliorate the ABR threshold increase at high frequencies (16 kHz and 32 ...
Source: Hearing Research - November 13, 2023 Category: Audiology Authors: Yijiang Bai Jing Liu Xuewen Wu Bo Pang Shuai Zhang Mengzhu Jiang Anhai Chen Huping Huang Yongjia Chen Yuan Zeng Lingyun Mei Kelei Gao Source Type: research
Susceptibility of immature spiral ganglion neurons to aminoglycoside-induced ototoxicity is mediated by the TRPV1 channel in mice
This study aimed to investigate whether a nonselective cation channel, TRPV1, contributes to the susceptibility of immature spiral ganglion neurons (SGNs) to the damage caused by aminoglycosides. Through western blotting and immunofluorescence, we found that the TRPV1 expression levels were much higher in immature SGNs than in their mature counterparts. In postnatal day 7 cochlear organotypic cultures, AMG-517 reduced reactive oxygen species generation and inhibited SGN apoptosis under aminoglycoside challenge. However, in adult mice, AMG-517 did not ameliorate the ABR threshold increase at high frequencies (16 kHz and 32 ...
Source: Hearing Research - November 13, 2023 Category: Audiology Authors: Yijiang Bai Jing Liu Xuewen Wu Bo Pang Shuai Zhang Mengzhu Jiang Anhai Chen Huping Huang Yongjia Chen Yuan Zeng Lingyun Mei Kelei Gao Source Type: research
