NIH Director's Seminar Series - Phthalate exposure and preterm birth: Findings from a pooled study of 16 US cohorts
Phthalates diesters are found ubiquitously in personal care products and plastics, and human exposure is widespread. Exposure in pregnancy is of particular concern due to the endocrine activity and suspected reproductive toxicity of these compounds. The Pooled Phthalate and Preterm Birth Study is a collaboration between 16 US cohorts established to better understand the relationship between exposure to phthalates in pregnancy and preterm birth. Under this study, we investigated three aims. First, we examined the association between prenatal phthalate exposure and preterm birth, as well as the potential benefits of hypothet...
Source: Videocast - All Events - January 26, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH ProtIG Seminar: The role of long-lived proteins in aging and Alzheimer ’ s disease
Loss of proteostasis is a hallmark of aging, and aging is the greatest risk factor for Alzheimer's disease (AD). Deterioration in function and accumulation of damage to the proteome are largely repaired by protein turnover. These turnover mechanisms are particularly important in long-lived postmitotic neurons, which cannot dilute toxic proteins through cell division. We aimed to identify extremely long-lived proteins (ELLP) that persist for several months or longer across the aging continuum in wild-type mice and in genetic AD mouse models. We hypothesize that these ELLPs represent key points of vulnerability to the declin...
Source: Videocast - All Events - November 30, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Trust Your Gut... Workshop (Day 2)
While in vivo rodent studies have historically been used for understanding gastrointestinal tract absorption and toxicity, animal models have well-documented anatomical, physiological, and biochemical differences from humans. Mammalian cell culture methods of varying complexity can be used in a variety of applications including rapid response, metabolism/metabolite secretion, and microbiome studies, and generating data for pharmacokinetic modeling. Accordingly, a workshop is being organized on the state of the science for using new approach methodologies to predict gastrointestinal tract absorption and toxicity.For more in...
Source: Videocast - All Events - September 26, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Trust Your Gut... Workshop (Day 1)
While in vivo rodent studies have historically been used for understanding gastrointestinal tract absorption and toxicity, animal models have well-documented anatomical, physiological, and biochemical differences from humans. Mammalian cell culture methods of varying complexity can be used in a variety of applications including rapid response, metabolism/metabolite secretion, and microbiome studies, and generating data for pharmacokinetic modeling. Accordingly, a workshop is being organized on the state of the science for using new approach methodologies to predict gastrointestinal tract absorption and toxicity.For more in...
Source: Videocast - All Events - September 26, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Colorized scanning electron microscope image of MXenes
A colorized scanning electron microscope image of tiny, finely layered metal structures known as MXenes, between which scientists can slip different ions for various purposes. These MXenes were grown using a simplified and less toxic method invented by researchers and hold promise for future ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - August 11, 2023 Category: Science Source Type: video
DNA Repair Interest Group - Young Investigators at 3 Sites
DNA Repair Interest Group
Jong Hyuk Lee, NIA and Mercer Univ, Atlanta, GA, Mitochondrial PARP1 Regulates NAD+-dependent Poly ADP-ribosylation on Mitochondrial Nucleoids; Matt Schaich, Univ of Pittsburgh, Single-Molecule Analysis of DNA-binding proteins from Nuclear Extracts (SMADNE); Jamie Hsing-Ming Chang, SUNY Stonybrook , NY, The Toxic and Genotoxic Impact of Artificially " Space-Weathered " Lunar Dust SimulantsAir date: 9/20/2022 12:30:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - September 7, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Empowerment of Under-represented Researchers / Women Leaders in Academic Research: How an Ear Worm Shapes My Life and My Career
Lessons learned from a career in science and trainee mentorship, with a discussion of some of the issues we face in the research community – health / mental health issues, toxic environments, micro-aggressions and discrimination. Series Description: Invited monthly lecture series highlighting and honoring women and under-represented leaders in science, industry, academics, policy, and advocacy. Originally from a combined effort of Interventional Radiology, Biomedical Engineering, Radiology, Imaging Sciences, Data Science, and Image-Guided Oncology, the series aimed to honor and promote women and confront disparities with...
Source: Videocast - All Events - May 20, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Well-Being and the Economic Burden of Disease: What Are We Learning From Cancer Survivors?
With increases in early detection and improved cancer treatments, we can now celebrate that many survivors can lead a full and healthy life after completing treatment. But we also know that the cancer journey can be stressful from diagnosis onward and well into survivorship. A major area of stress is finances, such as stress from increased medical costs and possibly reduced income and work productivity. The impact of “ financial toxicity ” on patient well-being is an emerging area of research.
Among Dr. Martin ’ s projects, she is multiple principal investigator of the Emotional Well-Being and Economic Burden Resea...
Source: Videocast - All Events - March 25, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
FES Emerging Chemicals (e.g., PFAS) /Management of Toxic Substances (e.g., Lead-based Paint, Mold, Asbestos) Track 1 (Day 1)
Presentations on Emerging Chemicals and the Management of Toxic Substances from FES ’ s from many government agenciesAir date: 3/28/2022 11:45:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - March 23, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
March 2022: EMedHome’s Video with Laura Bontempo, MD: Current Diagnosis and Management of Digoxin Toxicity
Dr. Bontempo discusses the best evidence for managing digoxin toxicity. (Source: Emergency Medicine News - Video)
Source: Emergency Medicine News - Video - March 1, 2022 Category: Databases & Libraries Source Type: video
Sodium batteries could one day bring the heat and the light.
What do you do when a major winter storm or a bolt of lightning has left you without power and the temperature in your home begins to plummet? Even if your back-up generator kicks in, you worry about the potential for fire and toxic fumes. Researchers are developing a sodium-based battery as an ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - February 4, 2022 Category: Science Source Type: video
Toward Personalizing HIV Treatment and Prevention
This is the annual Rolla E. Dyer Lecture. Speaker Namandje Bumpus's laboratory uses mass spectrometry and molecular pharmacology based approaches to investigate the biotransformation of clinically used drugs by the cytochromes P450s. The cytochromes P450 are responsible for the metabolism of an estimated 75 percent of currently marketed drugs. Cytochrome P450-mediated biotransformation of drugs most often results in the production of hydrophilic metabolites that can be readily excreted from the body; however, in certain instances toxic metabolites are formed that can stimulate cell death and organ failure.For more informat...
Source: Videocast - All Events - November 26, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Immunoglobulin Light Chain Amyloidosis – Biophysical and Cellular Studies of Misfolding, Toxicity, and Emerging Therapeutic Strategies
WALSMarina Ramirez-Alvarado, Ph.D., studies misfolding and amyloid formation in light chain amyloidosis. The overall goal of her research laboratory is to understand the molecular basis of this disease to find ways to ameliorate the organ damage it causes and find new therapeutic strategies to improve organ function and quality of life for patients, ultimately increasing overall survival.For more information go tohttps://oir.nih.gov/walsAir date: 6/30/2021 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - June 22, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
