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Special Event: Celebrating 20 Years of Harry Potter, Part 2
Monsters in the Stacks: How Harry Potter Came to NLM Stephen Greenberg, PhD, Head, Rare Books& Early Manuscripts, NLM History of Medicine Division Join us to learn how staff at the National Library of Medicine became inspired to undertake an exhibition about Harry Potter, drawing on collections of the Library, including works by real historical figures such as the alchemist Nicholas Flamel, who is a key figure in the first Harry Potter novel; the naturalist Conrad Gesner, who wrote about dragons and unicorns; and the mystic and toxicologist Paracelsus, whose potions and prophecies would have made him an excellent addit...
Source: Videocast - All Events - March 14, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video

Human pluripotent stem cells in understanding genetic cardiovascular disease and effects of drugs
NIH Director ’ s Wednesday Afternoon Lecture Series There's a growing interest in how the derivation of many different cell types from human pluripotent stem cells-embryonic stem cells (HESCs) and induced pluripotent stem cells (hiPS cells)-could be used for potential cell therapy and as a platform for drug discovery and toxicity. In particular, new methods of introducing specific disease mutations into human pluripotent stem cells and/or reprogramming them to derive hiPS cells, allow the creation of disease models " in a dish " so scientists can study ways to treat diseases or slow them down. To move the f...
Source: Videocast - All Events - January 23, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video

Against the Tide: A Fish Adapting Quickly to Lethal Levels of Pollution.
While environmental change is outpacing the rate of evolution for many other species, Atlantic killifish living in four polluted East Coast estuaries turn out to be remarkably resilient. These fish have adapted to levels of highly toxic industrial pollutants that would normally kill them.This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - January 10, 2017 Category: Science Source Type: video

Human pluripotent stem cells: the new patient?
NIH Director ’ s Wednesday Afternoon Lecture Series Derivation of many different cell types from human pluripotent stem cells (embryonic stem cells or HESCs and induced pluripotent stem cells or hiPS cells) is an area of growing interest both for potential cell therapy and as a platform for drug discovery and toxicity. Most particularly, the recent availability of methods to introduce specific disease mutations into human pluripotent stem cells and/or to derive these cells as hiPS cells by reprogramming from any patient of choice, are creating unprecedented opportunities to create disease models “ in a dish &rd...
Source: Videocast - All Events - December 23, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video

"Green" electronic materials produced with synthetic biology.
Scientists at UMass Amherst report in the current issue of Small that they have genetically designed a new strain of bacteria that spins out extremely thin and highly conductive wires made up solely of non-toxic, natural amino acids.This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - September 13, 2016 Category: Science Source Type: video

Translational Sciences in Oncology: To the Clinic and back again
NCI Center for Cancer Research Grand Rounds Dr. J. Carl Barrett is Vice President of Translational Science in Oncology at AstraZeneca. He is responsible for development and execution of biomarker strategies and translational sciences efforts to support compound development from research through early and full development in oncology. From 2005-2011, he was Global Head of Oncology Biomarkers and Imaging at Novartis. Dr. Barrett was the founding Director of the NCI Center for Cancer Research (CCR), the NCI intramural center for translation medicine. He was also Scientific Director at the National Institute of Environmental...
Source: Videocast - All Events - May 2, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video

The Role of RNA Editing in Malignant Reprogramming
NCI’s Center for Cancer Research (CCR) Grand Rounds Dr. Catriona Jamieson, M.D., Ph.D., is Associate Professor of Medicine, Chief of the Division of Regenerative Medicine, Co-Leader of the Hematologic Malignancies Program in the Division of Hematology-Oncology and Director of Stem Cell Research at the Moores UC San Diego Cancer Center. Dr. Jamieson specializes in myeloproliferative neoplasms (MPNs) and leukemia. Myeloproliferative neoplasms are a family of clonal bone marrow disorders in which the body overproduces blood cells. Myeloproliferative neoplasms can cause many forms of blood clotting including heart at...
Source: Videocast - All Events - April 4, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video

Principles of Clinical Pharmacology ~ Biochemical Mechanisms for Drug Toxicity
Presented by: Ashley Beasley Green, Ph.D., NISTCategory: Principles of Clinical PharmacologyAired date: 11/19/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - November 23, 2015 Category: Journals (General) Tags: Past Events Source Type: video

Principles of Pharmacology ~ Biochemical Mechanisms for Drug Toxicity
The "Principles of Clinical Pharmacology" course is a weekly lecture series covering the fundamentals of clinical pharmacology as a translational scientific discipline focused on rational drug development and utilization in therapeutics. The course is offered annually at the NIH Clinical Center and runs from September through April.Air date: 11/19/2015 6:30:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - October 26, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video

ICCVAM Public Forum - May 2015
Presented by: NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)Category: Advisory Board MeetingsAired date: 05/27/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - May 29, 2015 Category: Journals (General) Tags: Past Events Source Type: video

Expert Panel: Identifying Research Needs for Assessing Safe Use of High Intakes of Folic Acid (Day 2)
Presented by: National Toxicology Program and Office of Dietary Supplements Category: ConferencesAired date: 05/12/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - May 13, 2015 Category: Journals (General) Tags: Past Events Source Type: video

Expert Panel: Identifying Research Needs for Assessing Safe Use of High Intakes of Folic Acid (Day 1)
Presented by: National Toxicology Program and Office of Dietary SupplementsCategory: ConferencesAired date: 05/11/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - May 13, 2015 Category: Journals (General) Tags: Past Events Source Type: video

ICCVAM Public Forum - May 2015
ICCVAM’s goals include promotion of national and international partnerships between governmental and nongovernmental groups, including academia, industry, advocacy groups, and other key stakeholders. To foster these partnerships, ICCVAM holds annual public forums to share information and facilitate direct communication of ideas and suggestions from stakeholders. The upcoming meeting will begin with presentations by NICEATM and ICCVAM members on current activities related to the development and validation of alternative test methods and approaches for assessing acute systemic toxicity, endocrine activity, vaccine saf...
Source: Videocast - All Events - May 7, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video

CC Grand Rounds: Clinicopathologic Grand Rounds: Clinical Cases from the NIH Clinical Center: Recombinant Anti-CD22 Immunotoxin Therapy of Drug-Resistant Hairy Cell Leukemia: Eradication of Minimal Residual Disease Without Chemotherapy Toxicity
Presented by: Lead Presenters: Ira Pastan, MD Co-Chief, Laboratory of Molecular Biology, NCI, NIH and Robert J. Kreitman, MD Chief, Clinical Immunotherapy Section, Laboratory of Molecular Biology, NCI, NIHCategory: Clinical Center Grand RoundsAired date: 02/18/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - February 19, 2015 Category: Journals (General) Tags: Past Events Source Type: video

CC Grand Rounds: Clinicopathologic Grand Rounds: Clinical Cases from the NIH Clinical Center: Recombinant Anti-CD22 Immunotoxin Therapy of Drug-Resistant Hairy Cell Leukemia: Eradication of Minimal Residual Disease Without Chemotherapy Toxicity
For more information go to http://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 2/18/2015 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 23, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video

Expert Panel: Identifying Research Needs for Assessing Safe Use of High Intakes of Folic Acid (Day 2)
The National Toxicology Program (NTP) and Office of Dietary Supplements (ODS) are convening an expert panel to identify research needs related to the safe use of high intakes of folic acid based on consideration of the state of the science. The expert panel meeting will bring together experts from multiple disciplines including, but not limited to, epidemiology, nutrition, medicine, and toxicology. In preparation for this evaluation, screening of the literature was undertaken to identify potential adverse health effects for which further research might be warranted. A literature review document is being prepared on four he...
Source: Videocast - All Events - January 9, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video

Expert Panel: Identifying Research Needs for Assessing Safe Use of High Intakes of Folic Acid (Day 1)
The National Toxicology Program (NTP) and Office of Dietary Supplements (ODS) are convening an expert panel to identify research needs related to the safe use of high intakes of folic acid based on consideration of the state of the science. The expert panel meeting will bring together experts from multiple disciplines including, but not limited to, epidemiology, nutrition, medicine, and toxicology. In preparation for this evaluation, screening of the literature was undertaken to identify potential adverse health effects for which further research might be warranted. A literature review document is being prepared on four he...
Source: Videocast - All Events - January 9, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video

NIH Global Health Interest Group Fall 2014 Symposium "Hot Topics in Global Health"
NIH Global Health Interest Group Fall 2014 Symposium “Hot Topics in Global Health” Please register online https://www.surveymonkey.com/s/FVXJCMH Speakers: Linda S. Birnbaum, Ph.D., Director of the National Institute of Environmental Health Sciences (NIEHS) and the National Toxicology Program (NTP) “21st Century Challenges in Global Health: Addressing a Changing Environment” Michele Bloch, M.D., Ph.D., Chief, Tobacco Control Research Branch (TCRB), Behavioral Research Program (BRP), Division Cancer Control and Population Sciences (DCCPS), National Cancer Institute (NCI) “E-cigarettes: Wha...
Source: Videocast - All Events - September 8, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Adverse Outcome Pathways: From Research to Regulation (Day 3)
The workshop will explore how scientific progress in adverse outcome pathway concepts can improve regulatory assessment of chemical toxicity.Air date: 9/5/2014 1:30:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - September 4, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Redox Biology 2014 - NADPH Oxidase, Redox Imaging
Redox Biology Recent advances in the biochemistry of redox-active species and radicals are beginning to be translated into improvements in prevention and treatment of cancer. Traditionally, reactive species such as superoxide, hydrogen peroxide and nitric oxide (NO) are associated with toxicity; however, NO is useful in the treatment of angina and cardiovascular disease. Also, NO is involved in cancer tumor angiogenesis and apoptosis of cancer cells. This course is an overview presenting how redox-active species and radicals are generated; their effects on the cellular and physiological level, how they alter carcinogene...
Source: Videocast - All Events - August 21, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Redox Biology 2014 - Cancer Therapy, Redox Enzymology
Redox Biology Recent advances in the biochemistry of redox-active species and radicals are beginning to be translated into improvements in prevention and treatment of cancer. Traditionally, reactive species such as superoxide, hydrogen peroxide and nitric oxide (NO) are associated with toxicity; however, NO is useful in the treatment of angina and cardiovascular disease. Also, NO is involved in cancer tumor angiogenesis and apoptosis of cancer cells. This course is an overview presenting how redox-active species and radicals are generated; their effects on the cellular and physiological level, how they alter carcinogene...
Source: Videocast - All Events - August 21, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Redox Biology 2014 - Inflammation, Epidemiology
Redox Biology Recent advances in the biochemistry of redox-active species and radicals are beginning to be translated into improvements in prevention and treatment of cancer. Traditionally, reactive species such as superoxide, hydrogen peroxide and nitric oxide (NO) are associated with toxicity; however, NO is useful in the treatment of angina and cardiovascular disease. Also, NO is involved in cancer tumor angiogenesis and apoptosis of cancer cells. This course is an overview presenting how redox-active species and radicals are generated; their effects on the cellular and physiological level, how they alter carcinogene...
Source: Videocast - All Events - August 21, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Redox Biology 2014 - Signal Transduction, Redox Physiology
Redox Biology Recent advances in the biochemistry of redox-active species and radicals are beginning to be translated into improvements in prevention and treatment of cancer. Traditionally, reactive species such as superoxide, hydrogen peroxide and nitric oxide (NO) are associated with toxicity; however, NO is useful in the treatment of angina and cardiovascular disease. Also, NO is involved in cancer tumor angiogenesis and apoptosis of cancer cells. This course is an overview presenting how redox-active species and radicals are generated; their effects on the cellular and physiological level, how they alter carcinogene...
Source: Videocast - All Events - August 21, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Redox Biology 2014 - Redox Biology, Angiogenesis
Redox Biology Recent advances in the biochemistry of redox-active species and radicals are beginning to be translated into improvements in prevention and treatment of cancer. Traditionally, reactive species such as superoxide, hydrogen peroxide and nitric oxide (NO) are associated with toxicity; however, NO is useful in the treatment of angina and cardiovascular disease. Also, NO is involved in cancer tumor angiogenesis and apoptosis of cancer cells. This course is an overview presenting how redox-active species and radicals are generated; their effects on the cellular and physiological level, how they alter carcinogene...
Source: Videocast - All Events - August 21, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Redox Biology 2014 - Introduction, Redox Chemistry
Redox Biology Recent advances in the biochemistry of redox-active species and radicals are beginning to be translated into improvements in prevention and treatment of cancer. Traditionally, reactive species such as superoxide, hydrogen peroxide and nitric oxide (NO) are associated with toxicity; however, NO is useful in the treatment of angina and cardiovascular disease. Also, NO is involved in cancer tumor angiogenesis and apoptosis of cancer cells. This course is an overview presenting how redox-active species and radicals are generated; their effects on the cellular and physiological level, how they alter carcinogene...
Source: Videocast - All Events - August 21, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Adverse Outcome Pathways: From Research to Regulation (Day 2)
The workshop will explore how scientific progress in adverse outcome pathway concepts can improve regulatory assessment of chemical toxicity.Air date: 9/4/2014 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - August 20, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Adverse Outcome Pathways: From Research to Regulation (Day 1)
The workshop will explore how scientific progress in adverse outcome pathway concepts can improve regulatory assessment of chemical toxicity.Air date: 9/3/2014 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - August 20, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Detection of Dichlorvos Adducts on Proteins from a Liver-derived Cell Line
Proteomics Interest Group The toxicity of dichlorvos (DDVP), an organophosphate (OP) pesticide, classically results from modification of the serine in the active sites of cholinesterases. However, DDVP also forms adducts on unrelated targets such as transferrin and albumin, suggesting that DDVP could cause perturbations in cellular processes by modifying non-cholinesterase targets. Here, we identify novel DDVP-modified targets in lysed human hepatocyte-like cells (HepaRG) using a direct liquid chromatography-mass spectrometry (LC-MS) assay of cell lysates incubated with DDVP or using a competitive pull-down experiments wi...
Source: Videocast - All Events - February 27, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Nanotechnology: Multifunctional Smart Nanoparticles Measure Previously Invisible Diagnostic Analytes
Proteomics Interest Group A critical need within the biomedical research sector is the identification and reliable clinical measurement of novel low abundance biomarkers that are predictive of early stage diseases such as cancer, or that correlate with therapeutic outcome or toxicity. Unresolved challenges in the biomarker discovery and measurement field are 1) Early disease biomarkers exist in body fluids at a concentration below the detection limit of biomarker discovery and measurement platforms, 2) Proteins and peptides are masked by billion fold excess quantities of resident proteins such as immunoglobulin and albumi...
Source: Videocast - All Events - January 29, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Investigational New Drug (IND) Applications: What You Need to Know for Successful Interactions with the FDA
An educational program of the NIH Clinical Center-FDA CDER Joint Task Force emphasizing regulatory requirements for clinical trials of new and repurposed drugs, with a special focus on rare diseases. Target Audience: Clinical investigators, clinical research study coordinators, clinical and translational research scientists and trainees. Objectives: • To provide training in FDA regulations for NIH investigators involved in phase I and phase II clinical trials of investigational drugs, emphasizing safety considerations in the early phases of drug development. • To describe the IND-enabling elements of no...
Source: Videocast - All Events - November 7, 2013 Category: Journals (General) Tags: Upcoming Events Source Type: video

Organs-on-Chips as Tools for Predictive Efficacy and Toxicology Assessment of Therapeutics & The NIH Genetic Testing Registry
Audio PodcastPresented by: Office of Rare Diseases Research, the National Eye Institute, National Institute of Mental Health, and the NIH Office of DirectorAired date: 4/4/2013 2:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - April 19, 2013 Category: Journals (General) Tags: Podcasts Source Type: video

2013 Health in Buildings Roundtable
The Health in Buildings Roundtable (HiBR) joins the NIH Division of Environmental Protection and the American College of Sports Medicine in inviting you to attend a one-day conference designed to investigate the link between the built environment and human health. The goals of the HiBR conference are to identify aspects of the built environment that are detrimental to human health; to discuss design elements that can support improved human health; and to create the foundation for establishing a National agenda for public health research and policy. This innovative conference will be held on Tuesday, April 23, 2013 from 8:0...
Source: Videocast - All Events - April 15, 2013 Category: Journals (General) Tags: Upcoming Events Source Type: video

Organs-on-Chips as Tools for Predictive Efficacy and Toxicology Assessment of Therapeutics & The NIH Genetic Testing Registry
Organs-on-Chips as Tools for Predictive Efficacy and Toxicology Assessment of Therapeutics & The NIH Genetic Testing RegistryPresented by: Office of Rare Diseases Research, the National Eye Institute, National Institute of Mental Health, and the NIH Office of DirectorCategory: BiospecimensAired date: 04/04/2013 (Source: Videocast - All Events)
Source: Videocast - All Events - April 8, 2013 Category: Journals (General) Tags: Past Events Source Type: video

Organs-on-Chips as Tools for Predictive Efficacy and Toxicology Assessment of Therapeutics & The NIH Genetic Testing Registry
Video Podcast (CC)Presented by: Office of Rare Diseases Research, the National Eye Institute, National Institute of Mental Health, and the NIH Office of DirectorAired date: 4/4/2013 2:00:00 PM Eastern Time (Source: Videocast Podcasts)
Source: Videocast Podcasts - April 4, 2013 Category: Journals (General) Authors: National Institutes of Health Tags: Health Source Type: video

Organs-on-Chips as Tools for Predictive Efficacy and Toxicology Assessment of Therapeutics & The NIH Genetic Testing Registry
Audio PodcastPresented by: Office of Rare Diseases Research, the National Eye Institute, National Institute of Mental Health, and the NIH Office of DirectorAired date: 4/4/2013 2:00:00 PM Eastern Time (Source: Videocast Podcasts)
Source: Videocast Podcasts - April 4, 2013 Category: Journals (General) Authors: National Institutes of Health Tags: Health Source Type: video