Molecules, Vol. 29, Pages 1843: Anti-Tumor Effects and Toxicity Reduction Mechanisms of Prunella vulgaris: A Comprehensive Review
Conclusion: The active ingredients in the medicine food homology plant P. vulgaris not only treat digestive system tumors through different mechanisms but also reduce the toxic effects. P. vulgaris is worthy of being explored more deeply. (Source: Molecules)
Source: Molecules - April 18, 2024 Category: Chemistry Authors: Na Ning Yi Nan Guoqing Chen Shicong Huang Doudou Lu Yating Yang Fandi Meng Ling Yuan Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1539: Surgical Outcomes after Radiotherapy in Rectal Cancer
de Velde
Over the past decade, the treatment of rectal cancer has changed considerably. The implementation of TME surgery has, in addition to decreasing the number of local recurrences, improved surgical morbidity and mortality. At the same time, the optimisation of radiotherapy in the preoperative setting has improved oncological outcomes even further, although higher perineal infection rates have been reported. Radiotherapy regimens have evolved through the adjustment of radiotherapy techniques and fields, increased waiting intervals, and, for more advanced tumours, adding chemotherapy. Concurrently, imaging techniq...
Source: Cancers - April 18, 2024 Category: Cancer & Oncology Authors: Sofieke J. D. Temmink Koen C. M. J. Peeters Per J. Nilsson Anna Martling Cornelis J. H. van de Velde Tags: Review Source Type: research
Rehabilitation Implications of Cellular Therapy for Cancer
AbstractPurpose of ReviewThis paper aims to explore the rehabilitation implications of hematopoietic stem cell transplants (HSCT) and chimeric antigen receptor (CAR) T-cell therapy, addressing the dearth of literature on rehabilitation for CAR T-cell recipients compared to HSCT patients.Recent FindingsWhile HSCT recipients commonly face weakness and deconditioning, CAR T-cell therapy recipients experience unique toxicities like cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). Prehabilitation, rehabilitation, and prospective surveillance have emerged as crucial components i...
Source: Current Physical Medicine and Rehabilitation Reports - April 18, 2024 Category: Rehabilitation Source Type: research
Direct biosynthesis of massive intracellular CdSe QDS across entire S. oneidensis MR ‐1 for photosynthesis of hydrogen
AbstractIntracellular biosynthesis of massive quantum dots inside bacteria remains a grand challenge, with such a technology unsatisfactory due to the high toxicity of metal ions to the cell and the ultralow yield of quantum dots. Herein, agshA-overexpressedShewanella oneidensis MR-1 strain was constructed with the ability to effectively detoxify SeO32 − species, rendering the formation of substantial CdSe quantum dots across the entire cell entity. As such, the photoexcited electrons generated from the entire bacterium entity led to promoted electron mobilization efficiency and photoelectron-involved cellular energy met...
Source: AIChE Journal - April 17, 2024 Category: Science Authors: Xiaofeng Yi,
Shurui Liu,
Yixin Li,
Qingliu Luo,
Qingbiao Li,
Dong Xia,
Yuanpeng Wang Tags: RESEARCH ARTICLE Source Type: research
In vitro and in vivo exposure of endothelial cells to dibutyl phthalate promotes monocyte adhesion
Food Chem Toxicol. 2024 Apr 15;188:114663. doi: 10.1016/j.fct.2024.114663. Online ahead of print.ABSTRACTThe effect of endothelial cells' exposure to dibutyl phthalate (DBP) on monocyte adhesion is largely unknown. We evaluated monocyte adhesion to DBP-exposed endothelial cells by combining three approaches: short-term exposure (24 h) of EA.hy926 cells to 10-6, 10-5, and 10-4 M DBP, long-term exposure (12 weeks) of EA.hy926 cells to 10-9, 10-8, and 10-7 M DBP, and exposure of rats (28 and 90 days) to 100, 500, and 5000 mg DBP/kg food. Monocyte adhesion to human EA.hy926 and rat aortic endothelial cells, expression of selec...
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Dunja Kokai Jelena Markovic Filipovic Marija Opacic Ivana Ivelja Vojislav Banjac Bojana Stanic Nebojsa Andric Source Type: research
Effectiveness of statins in people living with HIV: a systematic review and meta-analysis of randomized controlled trials
CONCLUSION: When considered collectively, statin therapy's advantages appear to exceed its occasional predictable side effects like liver or muscle toxicity.REGISTRATION: PROSPERO registration ID: CRD42023469521.PMID:38629133 | DOI:10.1080/17512433.2024.2344672 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Sai Santhosha Mrudula Alla Dhruv J Shah Vysakh Ratheesh Deekshitha Alla Thanmayee Tummala Moksh S Khetan Ritika J Shah Ruth G Bayeh Mahek Fatima Sanah K Ahmed Mert Sab ıroğlu Source Type: research
Maintenance pembrolizumab therapy in patients with metastatic HER2-negative breast cancer with prior response to chemotherapy
CONCLUSIONS: Pembrolizumab monotherapy achieved durable treatment responses. Patients with a high baseline T-cell clonality had prolonged disease control with pembrolizumab.PMID:38629963 | DOI:10.1158/1078-0432.CCR-23-2947 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Toshiaki Iwase Evan N Cohen Hui Gao Angela Alexander Megumi Kai Vivian Chiv Xiaoping Wang Savitri Krishnamurthy Diane Liu Yu Shen Kumiko Kida Alexandre Reuben Rachel Layman David Ramirez Debu Tripathy Stacy L Moulder Clinton Yam Vicente Valero Bora Lim Ja Source Type: research
A Japanese multi-institutional phase II study of moderate hypofractionated intensity-modulated radiotherapy with image-guided technique for prostate cancer
CONCLUSION: The safety and efficacy of moderately hypofractionated IMRT with prostate-based image-guidance was confirmed among Japanese patients with prostate cancer.PMID:38630382 | DOI:10.1007/s10147-024-02517-z (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Katsumasa Nakamura Keiji Nihei Yoshihiro Saito Naoto Shikama Shin-Ei Noda Ryusuke Hara Toshiyuki Imagumbai Takashi Mizowaki Takeshi Akiba Etsuo Kunieda Masanori Someya Saiji Ohga Jiro Kawamori Takuyo Kozuka Yosuke Ota Koji Inaba Takeshi Kodaira Yoshiyuki Source Type: research
A Prospective Cohort Study Exploring the Effect of Lenvatinib Planned Drug Holidays in Treatment of Differentiated Thyroid Cancer
Conclusions: Planned drug holidays for lenvatinib were associated with significantly improved clinical outcomes compared to daily oral administration. Further investigation of the optimal treatment schedule for lenvatinib is warranted. Clinical Trial Registration: UMIN000022243.PMID:38629757 | DOI:10.1089/thy.2023.0553 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - April 17, 2024 Category: Endocrinology Authors: Makoto Tahara Hiroshi Takami Yasuhiro Ito Takahiro Okamoto Iwao Sugitani Kiminori Sugino Shunji Takahashi Hiroshi Takeyama Hidemitsu Tsutsui Hisato Hara Ayako Mitsuma Hiroyuki Yamashita Yasuo Ohashi Tsuneo Imai Source Type: research
Hematological toxicities post-CAR-T cells: Recommendations of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)
Bull Cancer. 2024 Apr 16:S0007-4551(24)00119-X. doi: 10.1016/j.bulcan.2024.02.013. Online ahead of print.ABSTRACTChimeric antigen receptor T cell (CAR-T cell) therapy has become a standard-of-care for several hematological and a promising treatment for solid malignancies or for selected non-malignant autoimmune disorders. Hematological complications following this treatment are very common with the majority of patients experiencing at least one cytopenia after CAR-T cell injections. The management of these adverse events is not standardized and represents an area of active research and unmet clinical needs. This harmonizat...
Source: Bulletin du Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Tamim Alsuliman Clotilde Aubrun Jacques Olivier Bay Yves Beguin Camille Bigenwald Eolia Brissot Yves Chalandon Patrice Chevallier Simona Pagliuca L éonardo Magro Micha Srour Source Type: research
Levels and Health Risk Assessments of Heavy Metals in Khat and Its Support Soil in Algesachi, Ilu Ababor, Ethiopia
CONCLUSION: The hazard index (HI) of metals in khat from study areas was less than 1 indicating a less likelihood of non-carcinogenic toxicological health effects. However, the presence of these toxic chemicals in soil and khat indicates product contamination and needs extensive further investigation involving other heavy metals.PMID:38628468 | PMC:PMC11020725 | DOI:10.1177/11786302241246455 (Source: Environmental Health Insights)
Source: Environmental Health Insights - April 17, 2024 Category: Environmental Health Authors: Shibiru Damana Abiyot Kelecha Geletu Ibrahim Umer Keru Source Type: research
The impact of nanomaterials on autophagy across health and disease conditions
Cell Mol Life Sci. 2024 Apr 17;81(1):184. doi: 10.1007/s00018-024-05199-y.ABSTRACTAutophagy, a catabolic process integral to cellular homeostasis, is constitutively active under physiological and stress conditions. The role of autophagy as a cellular defense response becomes particularly evident upon exposure to nanomaterials (NMs), especially environmental nanoparticles (NPs) and nanoplastics (nPs). This has positioned autophagy modulation at the forefront of nanotechnology-based therapeutic interventions. While NMs can exploit autophagy to enhance therapeutic outcomes, they can also trigger it as a pro-survival response ...
Source: Cellular and Molecular Life Sciences : CMLS - April 17, 2024 Category: Cytology Authors: Ida Florance Marco Cordani Parya Pashootan Mohammad Amin Moosavi Ali Zarrabi Natarajan Chandrasekaran Source Type: research
BIOACTIVES OF Melipona rufiventris PROPOLIS: EXPLORING ITS ANTIMICROBIAL, ANTI-INFLAMMATORY, AND ANTIOXIDANT ACTIVITIES
This study explores the potential of propolis from Melipona rufiventris species. With its composition encompassing resin, wax, pollen, and soil, propolis holds historical significance in traditional medicine within tropical regions. This research is driven by the scarcity of information surrounding M. rufiventris propolis, prompting an investigation into its chemical constituents, in vivo toxicity, and antimicrobial, antioxidant, and anti-inflammatory properties. This exploration could potentially uncover novel applications for this natural product, bolstering both meliponiculture practices and the preservation of native b...
Source: Chemistry and Biodiversity - April 17, 2024 Category: Biochemistry Authors: Amanda Tristao Santini Rayra Annara Otac ílio Pinto Josy Goldoni Lazarini Daniel Vieira de Morais Anna Maria Alves de Piloto Fernandes Marcelo Franchin Patricia Lunardelli Negreiros de Carvalho Carolina Girotto Pressete Pedro Luiz Rosalen Severino Matias Source Type: research
In vitro and in vivo exposure of endothelial cells to dibutyl phthalate promotes monocyte adhesion
Food Chem Toxicol. 2024 Apr 15;188:114663. doi: 10.1016/j.fct.2024.114663. Online ahead of print.ABSTRACTThe effect of endothelial cells' exposure to dibutyl phthalate (DBP) on monocyte adhesion is largely unknown. We evaluated monocyte adhesion to DBP-exposed endothelial cells by combining three approaches: short-term exposure (24 h) of EA.hy926 cells to 10-6, 10-5, and 10-4 M DBP, long-term exposure (12 weeks) of EA.hy926 cells to 10-9, 10-8, and 10-7 M DBP, and exposure of rats (28 and 90 days) to 100, 500, and 5000 mg DBP/kg food. Monocyte adhesion to human EA.hy926 and rat aortic endothelial cells, expression of selec...
Source: Food and Chemical Toxicology - April 17, 2024 Category: Food Science Authors: Dunja Kokai Jelena Markovic Filipovic Marija Opacic Ivana Ivelja Vojislav Banjac Bojana Stanic Nebojsa Andric Source Type: research
RIFM fragrance ingredient safety assessment, N,N-diethyloctamide, CAS Registry Number 996-97-4
Food Chem Toxicol. 2024 Apr 15:114657. doi: 10.1016/j.fct.2024.114657. Online ahead of print.NO ABSTRACTPMID:38631436 | DOI:10.1016/j.fct.2024.114657 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 17, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
