Low Dose of Nickel and Benzo [a] Anthracene in Rat-Diet, Induce Apoptosis, Fibrosis, and Initiate Carcinogenesis in Liver via NF- Ƙβ Pathway
This study was designed to evaluate the carcinogenic risk and other risks associated with long-term consumption of environmentally relevant dose of nickel and benzo [a] anthracene in rats. Thirty-six (36) male rats weighing between 80 and 100 g were assigned into 6 groups of 6 animals each; normal, nickel-, and benzo [a] anthracene-exposed groups for 12 and 24 weeks, respectively. Micronucleus and comet analyses were done in the blood, liver, and bone marrow. Liver function, redox, and inflammatory markers (AST, ALT, GGT, SOD, GSH, MDA, protein carbonyl, protein thiol, total protein, IL-10, 1L-1β, TNF-α, TGF-β NF-Ƙβ, ...
Source: Biological Trace Element Research - April 24, 2024 Category: Biology Authors: Adewale Adetutu Peter Ifeoluwa Adegbola Abiodun Bukunmi Aborisade Source Type: research
Fluorescent carbon dots for labeling of bacteria: mechanism and prospects-a review
Anal Bioanal Chem. 2024 Apr 24. doi: 10.1007/s00216-024-05300-1. Online ahead of print.ABSTRACTThe search for bacteria-labeling agents that are more efficient and less toxic compared to existing staining dyes is ongoing. Fluorescent quantum dots and carbon dots (CDs) have been extensively researched for various bioimaging applications. Priority is given to CDs due to several advantages, including lower toxicity, versatility in tuning their properties, and better photostability compared to metal-based quantum dots. Although significant progress is still needed to replace existing dyes with CDs for bacteria labeling, they of...
Source: Analytical and Bioanalytical Chemistry - April 24, 2024 Category: Chemistry Authors: Anisha Anand Chih-Ching Huang Jui-Yang Lai Darakhshan Bano Helen Indah Pardede Amina Hussain Sehresh Saleem Binesh Unnikrishnan Source Type: research
Identification of naphthalimide-derivatives as novel PBD-targeted polo-like kinase 1 inhibitors with efficacy in drug-resistant lung cancer cells
Eur J Med Chem. 2024 Apr 20;271:116416. doi: 10.1016/j.ejmech.2024.116416. Online ahead of print.ABSTRACTTargeting polo-box domain (PBD) small molecule for polo-like kinase 1 (PLK1) inhibition is a viable alternative to target kinase domain (KD), which could avoid pan-selectivity and dose-limiting toxicity of ATP-competitive inhibitors. However, their efficacy in these settings is still low and inaccessible to clinical requirement. Herein, we utilized a structure-based high-throughput virtual screen to find novel chemical scaffold capable of inhibiting PLK1 via targeting PBD and identified an initial hit molecule compound ...
Source: European Journal of Medicinal Chemistry - April 24, 2024 Category: Chemistry Authors: Pingping Li Yongkun Li Xuesong Ma Liangping Li Shulan Zeng Yan Peng Hong Liang Guohai Zhang Source Type: research
In vitro to in vivo extrapolation to derive a metabolism factor for estimating the aggregate exposure to salicylic acid after dermal exposure of its esters
In conclusion, these results indicate that not all substances contribute equally (or at all) to the systemic exposure to salicylic acid. Therefore, we propose a realistic metabolism correction factor by which the potential contribution of salicylate esters to the aggregate consumer exposure to salicylic acid from cosmetic use can be estimated.PMID:38658404 | DOI:10.1007/s00204-024-03749-8 (Source: Archives of Toxicology)
Source: Archives of Toxicology - April 24, 2024 Category: Toxicology Authors: Abdulkarim Najjar Sebastien Gr égoire Beate Nicol Andreas Natsch Nazanin Golbamaki Fanny Boisleve Amaia Irizar Brian Wall Angus Swinscoe Val érie Masini-Etévé Dan Selechnik Anne Marie Api Peter Griem Nicola Hewitt Estefania Cardamone Source Type: research
In silico evaluation of the potential allergenicity of a fungal biomass from Rhizomucor pusillus for use as a novel food ingredient
Regul Toxicol Pharmacol. 2024 Apr 22:105629. doi: 10.1016/j.yrtph.2024.105629. Online ahead of print.ABSTRACTThe world's hunger for novel food ingredients drives the development of safe, sustainable, and nutritious novel food products. For foods containing novel proteins, potential allergenicity of the proteins is a key safety consideration. One such product is a fungal biomass obtained from the fermentation of Rhizomucor pusillus. The annotated whole genome sequence of this strain was subjected to sequence homology searches against the AllergenOnline database (sliding 80-amino acid windows and full sequence searches). In ...
Source: Regulatory Toxicology and Pharmacology : RTP - April 24, 2024 Category: Toxicology Authors: Kevin Scaife Steve L Taylor Lucie Pa řenicová Richard E Goodman Trung D Vo Elisa Leune Mohamed Abdelmoteleb Yvonne Dommels Source Type: research
Triphenyltin chloride exposure inhibits meiotic maturation of mouse oocytes by disrupting cytoskeleton assembly and cell cycle progression
This study aimed to elucidate the mechanisms underlying the toxicological effects of TPTCL on oocytes. The obtained findings revealed that TPTCL exposure reduced polar body extrusion (PBE) and induced meiotic arrest. Mechanistically, TPTCL disrupted meiotic spindle assembly and chromosome alignment. Further analysis indicated a significant decrease in p-MAPK expression, and disturbances in the localization of Pericentrin and p-Aurora A in TPTCL exposed oocytes, which suggesting impaired microtubule organizing center (MTOC)function. Moreover, TPTCL exposure enhance microtubule acetylation and microtubule instability. Theref...
Source: Toxicology in Vitro - April 24, 2024 Category: Toxicology Authors: Cong Ma Hongzhen Ruan Huiru Cheng Zuying Xu Caiyun Wu Dan Liang Huifen Xiang Yunxia Cao Zhiming Ding Source Type: research
Bisphenol S enhances the cell proliferation ability of prostate cancer cells by regulating the expression of SDS
Toxicol In Vitro. 2024 Apr 22:105827. doi: 10.1016/j.tiv.2024.105827. Online ahead of print.ABSTRACTRecent times have witnessed an increase in both incidence and mortality rates of prostate cancer. While some individuals with localized or metastatic cancer may progress slowly with a lower mortality risk, those with intermediate or high-risk cancer often face a higher likelihood of death, despite treatment. Bisphenol A (BPA) has been linked to various cancers, including prostate and breast cancer, yet the relationship between bisphenol S (BPS) and human health remains underexplored. In our study, we employed ssGSEA analysis...
Source: Toxicology in Vitro - April 24, 2024 Category: Toxicology Authors: Guanqun Ju Xiangyang Zhan Xinglin Chen Tongtong Zhang Xinyu Zhai Chuanmin Chu Mingyue Tan Dongliang Xu Source Type: research
Quantitative assessment and monitoring of microplastics and nanoplastics distributions and lipid metabolism in live zebrafish using hyperspectral stimulated Raman scattering microscopy
Environ Int. 2024 Apr 20;187:108679. doi: 10.1016/j.envint.2024.108679. Online ahead of print.ABSTRACTMicroplastics (MP) and nanoplastics (NP) pollutions pose a rising environmental threat to humans and other living species, given their escalating presence in essential resources that living subjects ingest and/or inhale. Herein, to elucidate the potential health implications of MP/NP, we report for the first time by using label-free hyperspectral stimulated Raman scattering (SRS) imaging technique developed to quantitatively monitor the bioaccumulation and metabolic toxicity of MP/NP within live zebrafish larvae during the...
Source: Environment International - April 24, 2024 Category: Environmental Health Authors: Le Xin Meizhen Huang Zhiwei Huang Source Type: research
Synergistic suppression of BDNF via epigenetic mechanism deteriorating learning and memory impairment caused by Mn and Pb co-exposure
Ecotoxicol Environ Saf. 2024 Apr 23;277:116365. doi: 10.1016/j.ecoenv.2024.116365. Online ahead of print.ABSTRACTMicroglia, the resident immune cells of the central nervous system (CNS), play a dual role in neurotoxicity by releasing the NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome and brain-derived neurotrophic factor (BDNF) in response to environmental stress. Suppression of BDNF is implicated in learning and memory impairment induced by exposure to manganese (Mn) or lead (Pb) individually. Methyl CpG Binding Protein 2 (MeCp2) and its phosphorylation status are related to BDNF suppression. Protein phosphatas...
Source: Ecotoxicology and Environmental Safety - April 24, 2024 Category: Environmental Health Authors: Lancheng Wei Hongjian He Shuting Yang Qianqian Shi Xinhang Wang Liyuan Huang Jianyong Lu Yinghui Shen Kaikai Zhi Junni Xiang Chengying Chen Jiao Mo Zhijian Zheng Yunfeng Zou Xiaobo Yang Shen Tang Xiyi Li Cailing Lu Source Type: research
Comprehensive characterization of organics in oil sands process water in constructed mesocosms utilizing multiple analytical methods
This study aims to provide a thorough characterization of dissolved organics in oil sands process water (OSPW) in field-based aquatic mesocosms at both molecular and bulk measurement levels using multiple analytical methods. In a 3-year outdoor mesocosm experiment, the analysis of naphthenic acid (NA) species was conducted using ultra-performance liquid chromatography time-of-flight mass spectrometry (UPLC-TOFMS). The results revealed the removal of both total NAs (38% and 35%) and classical NAs (O2-NAs, 58% and 49%) in undiluted and half-diluted OSPW, respectively. The increased ratios of oxidized NAs (O3-O6 NAs) to class...
Source: Environmental Research - April 24, 2024 Category: Environmental Health Authors: Lingling Yang Asfaw Bekele Mohamed Gamal El-Din Source Type: research
Nano-Biogenic Heavy Metals Adsorptive Remediation for Enhanced Soil Health and Sustainable Agricultural Production
Environ Res. 2024 Apr 22:118926. doi: 10.1016/j.envres.2024.118926. Online ahead of print.ABSTRACTHazardous heavy metal (HM) pollution constitutes a pervasive global challenge, posing substantial risks to ecosystems and human health. The exigency for expeditious detection, meticulous monitoring, and efficacious remediation of HM within ecosystems is indisputable. Soil contamination, stemming from a myriad of anthropogenic activities, emerges as a principal conduit for HM ingress into the food chain. Traditional soil remediation modalities for HM elimination, while effective are labor-intensive, susceptible to secondary con...
Source: Environmental Research - April 24, 2024 Category: Environmental Health Authors: Ayush Jha Bindiya Barsola Diksha Pathania None Sonu Pankaj Raizada Pankaj Thakur Pardeep Singh Sarvesh Rustagi Ajit Khosla Vishal Chaudhary Source Type: research
Study on the role of CCM3 gene and lead exposure induced neurotoxicity through neurovascular units
This study aimed to determine the toxic effects of vascular CCM3 gene deficiency and lead (Pb) exposure on the nervous system. Lentiviral transfection was performed to generate a stable strain of brain microvascular endothelial cells with low CCM3 expression. MTT assay assessed the survival rate of cells exposed to Pb, determining the dose and duration of Pb exposure in vitro. Proteomic analysis was performed on the differentially expressed proteins in bEnd3 and HT22 cells and flow cytometry was used to detect cell apoptosis. Finally, urine samples from pregnant and postpartum women were subjected to ICP-MS to detect Pb le...
Source: Ecotoxicology and Environmental Safety - April 24, 2024 Category: Environmental Health Authors: Yumeng Li Yun Liu Kangkang Liu Tao Tao Liuxue Yang Ruxi Liu Hang Zhou Dan Liang Ying Zhang Danni Huang Yi Sun Source Type: research
Curcumin alleviates zearalenone-induced liver injury in mice by scavenging reactive oxygen species and inhibiting mitochondrial apoptosis pathway
In conclusion, CUR alleviated ZEN-induced liver injury in mice by scavenging ROS and inhibiting the mitochondrial apoptotic pathway.PMID:38657456 | DOI:10.1016/j.ecoenv.2024.116343 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - April 24, 2024 Category: Environmental Health Authors: Xiaopeng Yang Hao Zheng Junlong Niu Xiaoshuang Chen Hongfei Li Zhiyong Rao Yongpeng Guo Wei Zhang Zhixiang Wang Source Type: research
Sustainable Electrolytes: Design Principles and Recent Advances
Chemistry. 2024 Apr 23:e202400332. doi: 10.1002/chem.202400332. Online ahead of print.ABSTRACTToday, rechargeable batteries are omnipresent and essential for our existence. In order to improve the electrochemical performance of electric fields, the introduction of electrolytes with fluorine (F)-based inorganic elemental compositions is a direction of exploration. However, most fluorocarbons have a high global warming potential and ozone depletion potential, which do not meet the sustainability requirements of the battery industry. Therefore, developing sustainable electrolytes is a viable option for future battery developm...
Source: Chemistry - April 24, 2024 Category: Chemistry Authors: Xuemei Ma Dianwei Zhang Jie Wen Ling Fan Apparao M Rao Bingan Lu Source Type: research
Synergistic impact of bioavailable PHEs and alkalinity on microbial diversity and traits in agricultural soil adjacent to chromium-asbestos mines
This study aims to explore the combined effects of soil alkalinity and bioavailable PHEs on microbial diversity and traits in agricultural soil adjacent to a chromium-asbestos mining area. By employing a comprehensive analysis, this study indicated that microbiological attributes were reduced in contaminated areas (zone 1), whereas both the levels of bioavailable PHEs (CrWs: 31.08 mg/kg, NiWs: 13.90 mg/kg) and alkalinity indices (CROSS, MCAR, MH) were significantly higher. The spatial distribution of soil alkalinity and bioavailable PHEs, primarily originating from chromium-asbestos mines, has been determined. This study a...
Source: Environmental Pollution - April 24, 2024 Category: Environmental Health Authors: Sonali Banerjee Saibal Ghosh Shreya Chakraborty Dibyendu Sarkar Rupali Datta Pradip Bhattacharyya Source Type: research
