WITHANICANDRIN ISOLATED FROM Datura Ferox PROMOTES ANTINOCICEPTION BY MODULATING THE ASICS AND TRPS CHANNELS AND ANTI-INFLAMMATION IN ADULT ZEBRAFISH
Chem Biodivers. 2024 Apr 19:e202400538. doi: 10.1002/cbdv.202400538. Online ahead of print.ABSTRACTThis is the first study to analyze the anti-inflammatory and antinociceptive effect of withanicandrin, isolated from Datura Ferox leaves, and the possible mechanism of action involved in adult zebrafish (ZFa). To this end, the animals were treated intraperitoneally (i.p.) with withanicandrin (4; 20 and 40 mg/kg; 20 μL) and subjected to locomotor activity and acute toxicity. Nociception tests were also carried out with chemical agents, in addition to tests to evaluate inflammatory processes induced by κ-Carrageenan 1.5% and ...
Source: Chemistry and Biodiversity - April 19, 2024 Category: Biochemistry Authors: J éssica Bezerra Maciel Hort ência Ribeiro Liberato Ant ônio Wlisses da Silva Jo ão Pedro Vieira da Silva Francisco das Chagas L Pinto Emanuela de Lima Rebou ças Francisco Sydney Henrique da Silva Maria Kuerislene Am âncio Ferreira Marcia Machado Ma Source Type: research
Hierarchical self-recognition and response in CSC and non-CSC micro-niches for cancer therapy
Biomaterials. 2024 Apr 15;308:122581. doi: 10.1016/j.biomaterials.2024.122581. Online ahead of print.ABSTRACTCancer stem cells (CSCs) characterized by self-renewal, invasiveness, tumorigenicity and resistance to treatment are regarded as the thorniest issues in refractory tumors. We develop a targeted and hierarchical controlled release nano-therapeutic platform (SEED-NPs) that self-identifies and responds to CSC and non-CSC micro-niches of tumors. In non-CSC micro-niche, reactive oxygen species (ROS) trigger the burst release of the chemotherapeutic drug and photosensitizer to kill tumor cells and reduce tumor volume by c...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Yiliang Yang Yiwei Peng Yitian Du Meng Lin Jiajia Li Datong Gao Zhenzhen Yang Wei Wang Yanxia Zhou Xinru Li Taiqiang Yan Xianrong Qi Source Type: research
Investigation of the in vitro toxic effects induced by real-time aerosol of electronic cigarette solvents using microfluidic chips
This study constructed an original real-time aerosol exposure system, centered around a self-designed microfluidic bionic-lung chip, to assess the biological effects following exposure to aerosols from different solvents (PG, PG/VG mixture alone and PG/VG mixture in combination with nicotine) on BEAS-2B cells. The study aimed to investigate the impact of aerosols from different solvents on gene expression profiles, intracellular biomarkers (i.e., reactive oxygen species content, nitric oxide content, and caspase-3/7 activity), and extracellular biomarkers (i.e., IL-6, IL-8, TNF-α, and malondialdehyde) of BEAS-2B cells on-...
Source: Food and Chemical Toxicology - April 19, 2024 Category: Food Science Authors: Zezhi Li Xiang Li Boyang Feng Junwei Zhao Kejian Liu Fuwei Xie Jianping Xie Source Type: research
Elemental Composition of Toxic and Essential Elements in Rice-Based Baby Foods from the United States and other Countries: A Probabilistic Risk Analysis
Food Chem Toxicol. 2024 Apr 17:114677. doi: 10.1016/j.fct.2024.114677. Online ahead of print.ABSTRACTConsumption of rice-based foods provides essential nutrients required for infants and toddlers' growth. However, they could contain toxic and excess essential elements that may affect human health. The study aims to determine the composition of rice-based baby foods in the USA and outside and conduct a multiple-life stages probabilistic exposure and risk assessment of toxic and essential elements in children. Elemental concentrations were measured using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) in thirty-three r...
Source: Food and Chemical Toxicology - April 19, 2024 Category: Food Science Authors: Mom TatahMentan Syprose Nyachoti Tewodros Rango Godebo Source Type: research
Proteomic Profiling of Antimalarial Plasmodione Using 3-Benz(o)ylmenadione Affinity-Based Probes
Chembiochem. 2024 Apr 19:e202400187. doi: 10.1002/cbic.202400187. Online ahead of print.ABSTRACTUnderstanding the mechanisms of drug action in malarial parasites is crucial for the development of new drugs to combat infection and to counteract drug resistance. Proteomics is a widely used approach to study host-pathogen systems and to identify drug protein targets. Plasmodione is an antiplasmodial early-lead drug exerting potent activities against young asexual and sexual blood stages in vitro with low toxicity to host cells. To elucidate its molecular mechanisms, an affinity-based protein profiling (AfBPP) approach was app...
Source: Chembiochem - April 19, 2024 Category: Biochemistry Authors: Ilaria Iacobucci Vittoria Monaco Agn ès Hovasse Baptiste Dupouy Rodrigue Keumoe Bogdan Cichocki Mourad Elhabiri Brigitte Meunier Jean-Marc Strub Maria Monti Sarah Cianf érani St éphanie A Blandin Christine Schaeffer-Reiss Elisabeth Davioud-Charvet Source Type: research
Formation behavior of PCDD/Fs during waste pyrolysis and incineration: Effect of temperature, calcium oxide addition, and redox atmosphere
Environ Pollut. 2024 Apr 17:124011. doi: 10.1016/j.envpol.2024.124011. Online ahead of print.ABSTRACTThe clean and efficient utilization of municipal solid waste (MSW) has attracted increasing concerns in recent years. Pyrolysis of MSW is one of the promising options due to the production of high-value intermediates and the inhibition of pollutants at reducing atmosphere. Herein, the formation behavior of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) during MSW pyrolysis and incineration was experimentally investigated and compared. The influence of reaction temperature, CaO addition, and redox atmosphere o...
Source: Environmental Pollution - April 19, 2024 Category: Environmental Health Authors: Yuanjun Tang Dongsheng Tao Guoneng Li Chao Ye Zhongming Bu Rong Shen Yonghui Lin Wei Lv Source Type: research
Insights into the alleviation of cadmium toxicity in rice by nano-zinc and Serendipita indica: Modulation of stress-responsive gene expression and antioxidant defense system activation
Environ Pollut. 2024 Apr 17:123952. doi: 10.1016/j.envpol.2024.123952. Online ahead of print.ABSTRACTThe adversities of cadmium (Cd) contamination are quite distinguished among other heavy metals (HMs), and so is the efficacy of zinc (Zn) nutrition in mitigating Cd toxicity. Rice (Oryza sativa) crop, known for its ability to absorb HMs, inadvertently facilitates the bioaccumulation of Cd, posing a significant risk to both the plant itself and to humans consuming its edible parts, and damaging the environment as well. The use of nanoparticles, such as nano-zinc oxide (nZnO), to improve the nutritional quality of crops and t...
Source: Environmental Pollution - April 19, 2024 Category: Environmental Health Authors: Muhammad Faheem Adil Shafaque Sehar Zhengxin Ma Khajista Tahira Syed Muhammad Hassan Askri Mohamed A El-Sheikh Aqeel Ahmad Fanrui Zhou Ping Zhao Imran Haider Shamsi Source Type: research
Chemical speciation and environmental risk assessment of heavy metals in ash from smouldering combustion of oily sludge
Environ Pollut. 2024 Apr 17:124003. doi: 10.1016/j.envpol.2024.124003. Online ahead of print.ABSTRACTSmouldering combustion of oily sludge (OS) was carried out to learn the characteristics of heavy metals (HMs) in ash products. Ash collected from four different height layers of the column reactor was analysed for the chemical speciation and environmental risk of six HMs, including Cr, Ni, Cu, Zn, As, and Pb. The results showed that after smouldering combustion, only 21.3∼32.2 % of the total HMs was remained in the ash products. The retention of HMs in ash was closely relevant to the carbonaceous destruction efficiency of...
Source: Environmental Pollution - April 19, 2024 Category: Environmental Health Authors: Jingchun Huang Wenxia Wang Zihan Zheng Dongyan Zhang Chao Feng Yu Qiao Source Type: research
Structure optimizing of flavonoids against both MRSA and VRE
Eur J Med Chem. 2024 Apr 16;271:116401. doi: 10.1016/j.ejmech.2024.116401. Online ahead of print.ABSTRACTMethicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) cause more than 100,000 deaths each year, which need efficient and non-resistant antibacterial agents. SAR analysis of 162 flavonoids from the plant in this paper suggested that lipophilic group at C-3 was crucial, and then 63 novel flavonoid derivatives were designed and total synthesized. Among them, the most promising K15 displayed potent bactericidal activity against clinically isolated MRSA and VRE (MICs = 0.25-1.00 μg/mL...
Source: European Journal of Medicinal Chemistry - April 19, 2024 Category: Chemistry Authors: Mei-Zhen Wei Yan-Yan Zhu Wen-Biao Zu Huan Wang Li-Yu Bai Zhong-Shun Zhou Yun-Li Zhao Zhao-Jie Wang Xiao-Dong Luo Source Type: research
Chloroperfluoropolyether carboxylate compounds: a review
Chemosphere. 2024 Apr 17:142045. doi: 10.1016/j.chemosphere.2024.142045. Online ahead of print.ABSTRACTSeveral new per- and polyfluoroalkyl substances (PFASs) have been synthesized to replace traditional (legacy) PFASs frequently without clear information on their structure, use and potential toxicity. Among them, chloroperfluoropolyether carboxylates (ClPFPECAs) are an emerging group used as processing aids in the production of fluoropolymers to replace the ammonium salt of perfluorononanoic acid (PFNA). The Solvay Company has produced ClPFPECAs as a mixture of six congeners (oligomers) since the mid-1990s, but other poss...
Source: Chemosphere - April 19, 2024 Category: Chemistry Authors: Elisabetta Bucaletti Carolina Barola Roberta Galarini Source Type: research
Aloe-emodin: Progress in Pharmacological Activity, Safety, and Pharmaceutical Formulation Applications
Mini Rev Med Chem. 2024 Apr 18. doi: 10.2174/0113895575298364240409064833. Online ahead of print.ABSTRACTAloe-emodin (AE) is an anthraquinone derivative and a biologically active component sourced from various plants, including Rheum palmatum L. and Aloe vera. Known chemically as 1,8-dihydroxy-3-hydroxymethyl-anthraquinone, AE has a rich history in traditional medicine and is esteemed for its accessibility, safety, affordability, and effectiveness. AE boasts multiple biochemical and pharmacological properties, such as strong antibacterial, antioxidant, and antitumor effects. Despite its array of benefits, AE's identity as ...
Source: Mini Reviews in Medicinal Chemistry - April 19, 2024 Category: Chemistry Authors: Haimeng Luoa Xiaoyun Jia Mengyu Zhanga Yaoyao Renb Rui Tana Hezhong Jianga Xiaoqing Wua Source Type: research
Chloroperfluoropolyether carboxylate compounds: a review
Chemosphere. 2024 Apr 17:142045. doi: 10.1016/j.chemosphere.2024.142045. Online ahead of print.ABSTRACTSeveral new per- and polyfluoroalkyl substances (PFASs) have been synthesized to replace traditional (legacy) PFASs frequently without clear information on their structure, use and potential toxicity. Among them, chloroperfluoropolyether carboxylates (ClPFPECAs) are an emerging group used as processing aids in the production of fluoropolymers to replace the ammonium salt of perfluorononanoic acid (PFNA). The Solvay Company has produced ClPFPECAs as a mixture of six congeners (oligomers) since the mid-1990s, but other poss...
Source: Chemosphere - April 19, 2024 Category: Chemistry Authors: Elisabetta Bucaletti Carolina Barola Roberta Galarini Source Type: research
First vertebrate BRICHOS antimicrobial peptides: β-hairpin host defense peptides in limbless amphibia lung resemble those of marine worms
Biochem Biophys Res Commun. 2024 Apr 10;712-713:149913. doi: 10.1016/j.bbrc.2024.149913. Online ahead of print.ABSTRACTInnate immunity of invertebrates offers potent antimicrobial peptides (AMPs) against drug-resistant infections. To identify new worm β-hairpin AMPs, we explored the sequence diversity of proteins with a BRICHOS domain, which comprises worm AMP precursors. Strikingly, we discovered new BRICHOS AMPs not in worms, but in caecilians, the least studied clade of vertebrates. Two precursor proteins from Microcaecilia unicolor and Rhinatrema bivittatum resemble SP-C lung surfactants and bear worm AMP-like peptide...
Source: Biochemical and Biophysical Research communications - April 19, 2024 Category: Biochemistry Authors: Ruslan V Smetanin Maria S Sukhareva Elizaveta V Vladimirova Maria S Zharkova Anna D Mikushina Aleksey S Komlev Maria M Khaydukova Tatiana A Filatenkova Anastasia I Kalganova Sofiya O Pipiya Stanislav S Terekhov Dmitriy S Orlov Olga V Shamova Igor E Elisee Source Type: research
Acidic solvent improves cisplatin action in in-vitro
Biochem Biophys Res Commun. 2024 Apr 12;712-713:149936. doi: 10.1016/j.bbrc.2024.149936. Online ahead of print.ABSTRACTAs cisplatin is one of the most broadly used chemotherapeutics, it is widely tested in vitro & in vivo assays, involving attempts to better understand its mechanism of action, develop strategies to mitigate its toxicity, or develop new drug combinations. Presently, for in vitro assays, dissolving cisplatin in dimethyl sulfoxide (DMSO) is discouraged due to its significant reduction in drug activity, Alternatively, inorganic solvents like normal saline (NS) are recommended. However, this approach is sti...
Source: Biochemical and Biophysical Research communications - April 19, 2024 Category: Biochemistry Authors: Yuna Kim Hyeong-Min Lee Source Type: research
Mixed exposure to haloacetaldehyde disinfection by-products exacerbates lipid aggregation in the liver of mice
Environ Pollut. 2024 Apr 17:123971. doi: 10.1016/j.envpol.2024.123971. Online ahead of print.ABSTRACTHaloacetaldehyde disinfection by-products (HAL-DBPs) are among the top three unregulated DBPs found in drinking water. The cytotoxicity and genotoxicity of HALs are much higher than that of the regulated trihalomethanes and haloacetic acids. Previous studies have mainly focused on the toxic effects of single HALs, with few examining the toxic effects of mixed exposures to HALs. The study aimed to observe the effects of mixed exposures of 1∼1000X the realistic level of HALs on the hepatotoxicity and lipid metabolism of C57...
Source: Environmental Pollution - April 19, 2024 Category: Environmental Health Authors: Meiyue Qiu Lili Yang Zhiqiang Jiang Yu Chen Qinxin Liu Xia Wang Weidong Qu Source Type: research
