Synthesis and Antifungal Activity of Chalcone Derivatives Containing 1,3,4-thiadiazole
Chem Biodivers. 2024 May 20:e202401031. doi: 10.1002/cbdv.202401031. Online ahead of print.ABSTRACT24 chalcone derivatives containing 1,3,4-thiadiazole were synthesized. The results of bioactivity tests indicated that some of the target compounds exhibited superior antifungal activities in vitro. Notably, the EC50 value of D4 was 14.4 µg/mL against Phomopsis sp, which was significantly better than that of azoxystrobin (32.2 µg/mL) and fluopyram (54.2 µg/mL). The in vivo protective activity of D4 against Phomopsis sp on kiwifruit (71.2%) was significantly superior to azoxystrobin (62.8%) at 200 µg/mL. The in vivo protec...
Source: Chemistry and Biodiversity - May 21, 2024 Category: Biochemistry Authors: Wei Xue Tao Zhang Yi Liu Hui Xin Jiao Tian Tianyu Deng Kaini Meng Youshan An Source Type: research

Synthesis, Characterization, Antimicrobial and In Silico Studies of isatin Schiff base linked 1,2,3-triazole hybrids
Chem Biodivers. 2024 May 21:e202400569. doi: 10.1002/cbdv.202400569. Online ahead of print.ABSTRACTA new series of isatin-Schiff base linked 1,2,3-triazole hybrids has been synthesized using CuAAC approach from (E)-3-(phenylimino)-1-(prop-2-yn-1-yl)indolin-2-one derivatives in high yield (73-91 %). These synthesized derivatives were characterized using FT-IR, 1H NMR, 13C NMR, 2D-NMR and HRMS spectral techniques. The in vitro antimicrobial activity assay proposed that most of the tested hybrids exhibited promising activity. Compound 5j displayed good significant antibacterial efficacy against P. aeruginosa and B. subtilis w...
Source: Chemistry and Biodiversity - May 21, 2024 Category: Biochemistry Authors: Vijay Kumar Akanksha Bhukal Anirudh Pratap Singh Raman Prashant Singh Kashmiri Lal Source Type: research

Graphiumisides A-D, Monoterpene Glycosides from an Animal-Derived Endophytic Fungus Graphium  sp. GD-11
Chem Biodivers. 2024 May 21:e202400568. doi: 10.1002/cbdv.202400568. Online ahead of print.ABSTRACT Four new monoterpene rhamnosides, graphiumisides A-D (1-4), along with four known steroid compounds (5-8) were isolated from the fermentation extract of animal-derived endophytic fungus, Graphium sp. GD-11. The chemical structures of all compounds were elucidated using 1D and 2D NMR, HRESIMS spectroscopic analyses, and other spectroscopic methods. Compounds 1-4 exhibit a distinctive structure connected by one p-menthane type monoterpene and one L-rhamnose. This is the first report of monoterpene glycosides from Graphium sp. ...
Source: Chemistry and Biodiversity - May 21, 2024 Category: Biochemistry Authors: Mingyue Zhang Yuhang Zhang Mengshan Ji Dongyang Li Haibo Wang Xiaowei Wang Wenjun Wei Chengcheng Hui Tao Guo Source Type: research

Exploring the pharmacognostical and phytochemical profiles of aqueous extracts of Kalanchoe
This study aimed to differentiate K. crenata (KC), K. marmorata (KM), and K. pinnata (KP) by conducting detailed histochemical and phytochemical analyses, and to assess their antioxidant capabilities. The investigation revealed significant differences between the species, highlighting the variability in phenolic (PC) and flavonoid contents (FC) and their distinct antioxidant effects. The KM demonstrated the greatest results (PC: 59.26 ± 1.53 mgEqGA/g; FC: 12.63 ± 0.91 mgEqCQ/g; DPPH• (IC50): 110.66 ug/ml; ABTS•+ (IC50): 26.81 ug/ml; ORAC: 9.65 ± 0.75 mmolTE) when compared to KC and KP. These findings underscore a ne...
Source: Chemistry and Biodiversity - May 21, 2024 Category: Biochemistry Authors: Isadora Machinski Evelyn Assis de Andrade Vin ícius Monteiro Schaffka Valter Paes de Almeida Aline Santos Debora Bueno Wilmer Hervet Perera Romaiana Picada Pereira Jane Manfron Edmar Miyoshi Fl ávio Luís Beltrame Source Type: research

Labunicolamine: A Rare Penillic Acid Congener from the Nematode Cyst-Associated Fungus Laburnicola nematophila
Chem Biodivers. 2024 May 21:e202401152. doi: 10.1002/cbdv.202401152. Online ahead of print.ABSTRACTA chemical investigation of a methanol extract derived from a solid-state rice culture of the nematode-cyst associated fungus Laburnicola nematophila K01 led to the isolation and characterization of a previously undescribed penillic acid analogue named laburnicolamine (1). The chemical structure was elucidated through comprehensive 1D and 2D NMR spectroscopic analyses in methanol-d4 and DMSO-d6, alongside with HR-ESI-MS spectrometry. The absolute configuration of 1 was concluded through the electronic circular dichroism (ECD)...
Source: Chemistry and Biodiversity - May 21, 2024 Category: Biochemistry Authors: Jan-Peer Wennrich Caren Holzenkamp Samad Ashrafi Wolfgang Maier Hao Wang Mahmoud A A Ibrahim Sherif S Ebada Marc Stadler Source Type: research

Insights into the Biological Activities and Substituent Effects of Pyrrole Derivatives: The Chemistry-Biology Connection
Chem Biodivers. 2024 May 21:e202400534. doi: 10.1002/cbdv.202400534. Online ahead of print.ABSTRACTPyrrole, with its versatile heterocyclic ring structure, serves as a valuable template for generating a diverse range of lead compounds with various pharmacophores. Researchers and scientists globally are intrigued by pyrrole and its analogues for their broad pharmacological potential, prompting thorough investigations aimed at advancing human welfare. This comprehensive review delves into the diverse activities exhibited by pyrrole compounds, encompassing their synthesis, reactions, and pharmacological properties alongside t...
Source: Chemistry and Biodiversity - May 21, 2024 Category: Biochemistry Authors: B S Manya Pradeep Kumar M R Kalirajan Rajagopal Md Abul Hassan Safia Obaidur Rab Mohammed Ali Alshehri Talha Bin Emran Source Type: research

Antiproliferative potential of essential oil from the leaves of Croton floribundus  (Euphorbiaceae) against human metastatic melanoma cell lines
Chem Biodivers. 2024 May 21:e202400692. doi: 10.1002/cbdv.202400692. Online ahead of print.ABSTRACTMelanoma is a cancer type with high lethality, metastatic capacity, and limited therapeutic options. Different essential oils have been reported with antitumoral potential. Thus, the essential oil (EO) of the leaves of C. floribundus was obtained by hydrodistillation and analyzed by GC-MS. The majority of substances annotated were β-selinene, E-Caryophyllene, and Premnaspirodiene. The cytotoxic activity of EO was evaluated on three melanoma cell lines SKMEL-147, WM-1366, and CHL-1, which are representative of metastatic mela...
Source: Chemistry and Biodiversity - May 21, 2024 Category: Biochemistry Authors: Daniela A Garcia Lara P D M Costa Welton Rosa Ana Cl áudia Ladvocat Danielle F Dias Marisi G Soares Marisa Ionta Daniela Aparecida Chagas de Paula Source Type: research

Grape Pomace Polyphenols Reduce Acute Inflammatory Response Induced by Carrageenan in a Murine Model
This study investigates the anti-inflammatory properties of a polyphenolic fraction derived from GP, obtained by ultrasound-microwave hybrid extraction and purified using ion-exchange chromatography. In the inflammation model, mice were divided into six groups: intact, carrageenan, indomethacin, and three GP polyphenols treatment groups. Paw edema was induced by subplantar injection of carrageenan, and the GP polyphenols were administered intraperitoneally at doses of 10, 20, and 40 mg/kg. The anti-inflammatory effect was evaluated by measuring paw volume, and expression of inflammatory markers: cyclooxygenase-2 (COX-2), m...
Source: Chemistry and Biodiversity - May 20, 2024 Category: Biochemistry Authors: Sendar Daniel Nery-Flores Cristina Marisela Castro-L ópez Luc ía Martínez-Hernández Clara Victoria Garc ía-Chávez Lissethe Palomo-Ligas Juan Alberto Ascacio-Vald és Adriana Carolina Flores-Gallegos Lizeth Guadalupe Campos-M úzquiz Ra úl Rodrígue Source Type: research

Biomimetic chemical reactions with natural products using metalloporphyrins and salen complexes as catalysts: a brief review
Chem Biodivers. 2024 May 19:e202400668. doi: 10.1002/cbdv.202400668. Online ahead of print.ABSTRACTThe cytochrome P450 is a superfamily of hemoproteins mainly present in the liver and are versatile biocatalysts. They participate in the primary metabolism and biosynthesis of various secondary metabolites. Chemical catalysts are utilized to replicate the activities of enzymes. Metalloporphyrins and Salen complexes can contribute to the products' characterization and elucidate biotransformation processes, which are investigated during pre-clinical trials. These catalysts also help discover biologically active compounds and ge...
Source: Chemistry and Biodiversity - May 19, 2024 Category: Biochemistry Authors: Rita de C ássia Nascimento Sousa Vitor de Paiva Porf írio Confessor Antonio Kerverson Batista da Silva Addison Ribeiro Almeida Francisco Ayrton Senna Domingos Pinheiro Leandro De Santis Ferreira Source Type: research

Biomimetic chemical reactions with natural products using metalloporphyrins and salen complexes as catalysts: a brief review
Chem Biodivers. 2024 May 19:e202400668. doi: 10.1002/cbdv.202400668. Online ahead of print.ABSTRACTThe cytochrome P450 is a superfamily of hemoproteins mainly present in the liver and are versatile biocatalysts. They participate in the primary metabolism and biosynthesis of various secondary metabolites. Chemical catalysts are utilized to replicate the activities of enzymes. Metalloporphyrins and Salen complexes can contribute to the products' characterization and elucidate biotransformation processes, which are investigated during pre-clinical trials. These catalysts also help discover biologically active compounds and ge...
Source: Chemistry and Biodiversity - May 19, 2024 Category: Biochemistry Authors: Rita de C ássia Nascimento Sousa Vitor de Paiva Porf írio Confessor Antonio Kerverson Batista da Silva Addison Ribeiro Almeida Francisco Ayrton Senna Domingos Pinheiro Leandro De Santis Ferreira Source Type: research

Uncommon Epoxyquinols   Pyrrolocytosporin A and cytosporin E2from the Fungus Eutypella sp. D-1
Chem Biodivers. 2024 May 17:e202401097. doi: 10.1002/cbdv.202401097. Online ahead of print.ABSTRACTTwo uncommon epoxyquinols, pyrrolocytosporin A (1) and cytosporin E2 (2), along with the known cytosporin Y1 (3), were isolated from the solid defined medium of the Arctic-derived fungus Eutypella sp. D-1. Their structures were established through comprehensive analyses of spectroscopic and electronic circular dichroism data. Structurally, compound 1 represented the first nitrogen-containing epoxyquinol characterized by a pyrrole fused cytosporin framework, while compound 2 contained an uncommon cyclic carbonate functionality...
Source: Chemistry and Biodiversity - May 18, 2024 Category: Biochemistry Authors: Hao-Bing Yu Lin Du Zhe Ning Xiaoling Lu Bing-Hua Jiao Bo Hu Xiao-Yu Liu Source Type: research

Uncommon Epoxyquinols   Pyrrolocytosporin A and cytosporin E2from the Fungus Eutypella sp. D-1
Chem Biodivers. 2024 May 17:e202401097. doi: 10.1002/cbdv.202401097. Online ahead of print.ABSTRACTTwo uncommon epoxyquinols, pyrrolocytosporin A (1) and cytosporin E2 (2), along with the known cytosporin Y1 (3), were isolated from the solid defined medium of the Arctic-derived fungus Eutypella sp. D-1. Their structures were established through comprehensive analyses of spectroscopic and electronic circular dichroism data. Structurally, compound 1 represented the first nitrogen-containing epoxyquinol characterized by a pyrrole fused cytosporin framework, while compound 2 contained an uncommon cyclic carbonate functionality...
Source: Chemistry and Biodiversity - May 18, 2024 Category: Biochemistry Authors: Hao-Bing Yu Lin Du Zhe Ning Xiaoling Lu Bing-Hua Jiao Bo Hu Xiao-Yu Liu Source Type: research

Tributelosides A-D: Four Undescribed Spirostan Glycosides Isolated from the Branches and Leaves of Tribulus terrestris with Their NO Production Inhibitory Activity in LPS Activated RAW 264.7 Cells
Chem Biodivers. 2024 May 16:e202401049. doi: 10.1002/cbdv.202401049. Online ahead of print.ABSTRACTFour undescribed spirostan glycosides, (25S)-5α-spirostan-12-one-2α,3β-diol-3-O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside (1), (25S)-5α-spirostan-12-one-2α,3β-diol-3-O-β-D-galatopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside (2), (25S)-5α-spirostan-12-one-2α,3β-diol-3-O-β-D-glucopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→3)]-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside (3), and hecogenin 3-O-β-D-glucopyranosyl-(1→3)-[β-D-xylopyranosyl-(1→2)]-β-D-glucopyranosyl-(1→4)-[...
Source: Chemistry and Biodiversity - May 17, 2024 Category: Biochemistry Authors: Nguyen Van Quoc Nguyen Huy Hoang Bui Huu Tai Pham Hai Yen Nguyen Thi Cuc Phan Thi Thanh Huong Duong Thi Dung Do Thi Trang Nguyen The Cuong Le Duc Giang Phan Van Kiem Source Type: research

Therapeutic Promises of Ferulic Acid and Its Derivatives on Hepatic damage Related with Oxidative Stress and Inflammation: A Review with Mechanisms
This study aims to investigate the hepatoprotective effect of FA and its derivatives (methyl ferulic acid and trans-ferulic acid) against oxidative stress and inflammation-related hepatotoxicity due to toxicants based on the results of different non-clinical and preclinical tests. For this, data was collected from different reliable electronic databases such as PubMed, Google Scholar, and ScienceDirect, etc. The results of this investigation demonstrated that FA and its derivatives have potent hepatoprotective effects against oxidative stress and inflammation-related damage. The findings also revealed that these protective...
Source: Chemistry and Biodiversity - May 17, 2024 Category: Biochemistry Authors: Md Shimul Bhuia Raihan Chowdhury Manik Shill Afsana Chowdhury Henrique Coutinho Davi Silva Antonio Raposo Muhammad Torequl Islam Source Type: research

Exploring the recent pioneering developments of small molecules in antimalarial drug armamentarium: A chemistry prospective appraisal
Chem Biodivers. 2024 May 17:e202400460. doi: 10.1002/cbdv.202400460. Online ahead of print.ABSTRACTMalaria is a very destructive and lethal parasitic disease that causes significant mortality worldwide, resulting in the loss of millions of lives annually. The uncontrolled intake of antimalarial drugs often employed in clinical settings has resulted in the emergence of numerous strains of plasmodium that are resistant to these drugs, including multidrug-resistant strains. Hence, there is an urgent need for developing unique classes of antimalarial drugs that function with distinct mechanisms of action. In this context, the ...
Source: Chemistry and Biodiversity - May 17, 2024 Category: Biochemistry Authors: Tameika Bagratee Ritika Prawlall Thabani Ndlovu Sinqobile Sibisi Sisa Ndadane Baji Baba Shaik Mahesh B Palkar Raghavachary Gampa Rajshekhar V Karpoormath Source Type: research