Orthogonal Test Design for Optimization of the Extraction of Polysaccharides from Inonotus cuticularis and Their Antioxidant Activities.
In this study, the optimum yield of Inonotus cuticularis polysaccharides was determined by the orthogonal experimental design. The highest yield of 3.10±0.06 % was obtained with extraction temperature of 80 °C, extraction time of 150 min, and water to raw material ratio of 30 mL/g and repeated twice. After deproteinization for 5 times, the protein removal rate reached 70.10±1.75 %, and the content of polysaccharides and protein were 46.64 and 0.42 %. Infrared spectrometer indicated that Inonotus cuticularis polysaccharides are typical β-pyranose with characteristic pea...
Source: Chemistry and Biodiversity - August 3, 2020 Category: Biochemistry Authors: Guo L, Ma JY, Ma YZ, Zhang TL, Mao SL, Kong DX, Hua Y Tags: Chem Biodivers Source Type: research

Lignans, Monoterpenes and γ-Pyrone Derivatives from Patrinia scabiosaefolia with Cytotoxic Activity against HCT-116 Cells.
Lignans, Monoterpenes and γ-Pyrone Derivatives from Patrinia scabiosaefolia with Cytotoxic Activity against HCT-116 Cells. Chem Biodivers. 2020 Aug 02;: Authors: Zhang X, Rui M, Xu HT, Chou G Abstract One new dihydrobenzofuran neolignan, patrinianeolignan I ( 1 ), two new monoterpenes, 6,7-dehydrodissectol A ( 2 ) and patriniaol A ( 3 ), and a new γ -pyrone derivative, hydroxymaltol 3-O-(6'-O- trans -caffeoyl)- β -D-glucopyranoside ( 4 ), along with fifteen known lignans ( 5 - 19 ), eight known monoterpenes ( 20-27 ), and two known &ga...
Source: Chemistry and Biodiversity - August 2, 2020 Category: Biochemistry Authors: Zhang X, Rui M, Xu HT, Chou G Tags: Chem Biodivers Source Type: research

Recent Advances in the Tissue Culture of American Ginseng (Panax Quinquefolius).
Abstract The in vitro tissue culture of American ginseng has wide commercial applications in pharmaceutical, nutraceutical, food, and cosmetic fields with regard to the production of bioactive compounds such as ginsenosides and polysaccharides. This review highlights the recent progress made on different types of tissue culture practices with American ginseng, including callus culture, somatic embryo culture, cell suspension culture, hairy root culture, and adventitious root culture. The tissue culture conditions for inducing ginseng callus, somatic embryos, cell suspension, hairy roots, and adventitious roots wer...
Source: Chemistry and Biodiversity - July 30, 2020 Category: Biochemistry Authors: Gao Y, Qiang B, Miao J, Phillips N, Wei K Tags: Chem Biodivers Source Type: research

Antioxidant activity of flavonoid rich fraction of Ligaria cuneifolia (Ruiz & Pav.) Tiegh (Loranthaceae).
Antioxidant activity of flavonoid rich fraction of Ligaria cuneifolia (Ruiz & Pav.) Tiegh (Loranthaceae). Chem Biodivers. 2020 Jul 28;: Authors: Dobrecky CB, Marchini T, Ricco R, Garcés M, Gadano A, Carballo M, Wagner M, Lucangioli S, Evelson P Abstract Ligaria cuneifolia (Ruiz & Pav.) Tiegh (Loranthaceae), the "Argentine mistletoe", is a hemiparasite species largely used in folk medicine. The aim of this study was to evaluate the antioxidant activity using in vitro, ex vivo, and in vivo methods. A screening of phenolics was performed by UV spectroscopy on different fractions....
Source: Chemistry and Biodiversity - July 28, 2020 Category: Biochemistry Authors: Dobrecky CB, Marchini T, Ricco R, Garcés M, Gadano A, Carballo M, Wagner M, Lucangioli S, Evelson P Tags: Chem Biodivers Source Type: research

Major Fatty Acid Profiles and Bioactivity of Seed Oils from Ten Tree Peony Cultivars as a Potential Raw Material Source for the Cosmetics and Healthy Products.
Abstract As a new woody oleaginous crop, tree peony is now being widely developed and utilized, which attributed to the outstanding oil-use features regarding the fatty acid profiles and bioactivity. The major fatty acid profiles and bioactivity of seed oils in ten tree peony varieties collected from a common garden were investigated in the present study. The results showed that the oil yields, fatty acid profiles, bioactivity of seed oils existed significant variations among ten tree peony varieties (P
Source: Chemistry and Biodiversity - July 23, 2020 Category: Biochemistry Authors: Liu W, Zhang T, Yin D, Song P, Hou X, Qiao Q, Qi Z Tags: Chem Biodivers Source Type: research

Antiparasitic activity of bromotyrosine alkaloids and new analogues isolated from the Fijian marine Sponge Aplysinella rhax.
ars M Abstract Ten bromotyrosine alkaloids( 1 - 10 ) were isolated and characterised from the marine sponge Aplysinella rhax ( de Laubenfels 1954) collected from the Fiji Islands, which included one new bromotyrosine analogue, psammaplin P ( 6 )  and two other analogues, psammaplins O ( 5 ) and 4-bromo-6-carbomethoxy salicylic acid ( 7 ), which have not been previously reported from natural sources.  HRESIMS, 1D and 2D NMR spectroscopic methods were used in the elucidation of the compounds. Bisaprasin, a biphenylic dimer of psammaplin A, showed moderate activity with IC 50 at 19+/- 5 and 29+/- 6 μM ag...
Source: Chemistry and Biodiversity - July 22, 2020 Category: Biochemistry Authors: Oluwabusola ET, Tabudravu JN, Al Maqbali KS, Annang F, Pérez-Moreno G, Reyes F, Jaspars M Tags: Chem Biodivers Source Type: research

Design, synthesis and biological evaluation of xanthone derivatives for possible treatment of Alzheimer's disease based on multi-target strategy.
Abstract Four xanthone derivatives were synthesized and evaluated as acetylcholinesterase inhibitors (AChEIs) with metal chelating ability and antioxidant ability against Alzheimer's disease (AD). Most of them exhibited potential acetylcholinesterase (AChE), butylcholinesterase (BuChE) inhibitory, antioxidant and metal chelating properties. Among them, 3-(2-( pyrrolidinyl)ethoxy)-1- hydroxy-9H-xanthen-9-one ( 2 ) had the highest ability to inhibit AChE and displayed high selectivity towards AChE (IC 50 =2.403±0.002 μM for AChE and IC 5...
Source: Chemistry and Biodiversity - July 21, 2020 Category: Biochemistry Authors: Yang A, Yu Q, Ju H, Song L, Kou X, Shen R Tags: Chem Biodivers Source Type: research

New Antibacterial Thiodiketopiperazines from the Deep Sea Sediment-Derived Fungus Epicoccum nigrum SD-388.
Abstract Two new antibacterial thiodiketopiperazine derivatives (TDKPs), 7-dehydroxyepicoccin H and 7-hydroxyeutypellazine F, along with seven known TDKP analogs, were isolated and identified from Epicoccum nigrum SD-388, a deep-sea-sediment-derived fungus. The structures of these compounds were elucidated on the basis of detailed spectroscopic analysis. The absolute configuration of 7-dehydroxyepicoccin H was established by X-ray crystallographic analysis, while 7-hydroxyeutypellazine F was determined by ECD experiment and TDDFT-ECD calculation. The antibacterial activities against human and aquatic pathogens wer...
Source: Chemistry and Biodiversity - July 20, 2020 Category: Biochemistry Authors: Chi LP, Li XM, Li X, Wang BG Tags: Chem Biodivers Source Type: research

Design, synthesis and antifungal activities of 6-substituted  n-butyphthalide derivatives against phytopathogenic fungi.
Design, synthesis and antifungal activities of 6-substituted n-butyphthalide derivatives against phytopathogenic fungi. Chem Biodivers. 2020 Jul 20;: Authors: Fan L, Li Y, Luo Z, Luo B, Lan Q, Fan J, Xue W, Miao J, Li Y, Tang L Abstract In order to discover novel potential antifungal agents, a series of 6-substituted n-butyphthalide derivatives were designed, synthesized and evaluated for their antifungal activities against nine phytopathogenic fungi. Preliminary bioassay tests showed that compounds n-butyphthalide, 3 , 4 , 6a , 7a and 7b exhibited more potent antifungal activities that hyme...
Source: Chemistry and Biodiversity - July 20, 2020 Category: Biochemistry Authors: Fan L, Li Y, Luo Z, Luo B, Lan Q, Fan J, Xue W, Miao J, Li Y, Tang L Tags: Chem Biodivers Source Type: research

Chemical constituents from endophytic fungus Annulohypoxylon cf. stygium in leaves of Anoectochilus roxburghii (Wall.) Lindl.
Abstract The chemical investigation on endophytic fungus Annulohypoxylon cf. stygium in leaves of Anoectochilus roxburghii (Wall.) Lindl. Sixteen compounds were isolated and their structures were identified as palmarumycin CP2 ( 1 ), (-)-(3R)-mellein methyl ethe ( 2 ), kipukasins D ( 3 ), kipukasins E ( 4 ), secosterigmatocystin ( 5 ), notoamide D ( 6 ), notoamide C ( 7 ), (+)-versicolamide B ( 8 ), (-)-notoamide A ( 9 ), (-)-notoamide B ( 10 ), diorcinal ( 11 ), stephacidin A ( 12 ), sterigmatocystin ( 13 ), versiconol ( 14 ), dihydrosterigmatocystin ( 15 ), and averufanin ( 16 ) respectively by spectroscopic ana...
Source: Chemistry and Biodiversity - July 16, 2020 Category: Biochemistry Authors: Gao S, Tian WJ, Liao ZJ, Wang GH, Zeng DQ, Liu XZ, Wang XY, Zhou H, Chen HF, Lin T Tags: Chem Biodivers Source Type: research

Lipophilic metabolites of Spartina maritima and Puccinellia maritima involved in their tolerance to salty environments.
Abstract Spartina maritima and Puccinellia maritima are two fascinating but underexplored halophytic species, and herein is described their hexane extracts chemical profile. Terpenoids and sterols were the most abundant chemical group in both species. The second dominant class was alcohols and the third esters of fatty acids. The chemical lipophylic profile of both S. maritima and P. maritima is herein reported for the first time. Through the accomplished data, it is possible to conclude that these species are rich in essential compounds that can be relevant to endorse their use as nutraceuticals. Furthermore, thr...
Source: Chemistry and Biodiversity - July 14, 2020 Category: Biochemistry Authors: Faustino MV, Faustino A, Silva H, Silva A, Pinto D Tags: Chem Biodivers Source Type: research

Development and Validation of HPLC Method for Determination of Sodium Copper Chlorophyllin - A Food Colorant and Its Application in Pharmacokinetic Study.
Abstract A simple, accurate, and precise bioanalytical method was developed and validated for the determination of pharmacokinetic parameters of sodium copper chlorophyllin, a USFDA approved food additive and colorant in rat plasma. The column used was Luna® C18 250×4.6 mm, 100 Å, having particle size 4.5 μm, and the mobile phase used was methanol (MeOH), and 10 mM ammonium acetate buffer in the ratio of 90 : 10, the flow rate was 1 ml/min, and the injection volume of 20 μL. The retention time of sodium copper chlorophyllin was obtained at 9 min. The method was found...
Source: Chemistry and Biodiversity - July 14, 2020 Category: Biochemistry Authors: Laddha AP, Nalawade VV, Gharpure M, Kulkarni YA Tags: Chem Biodivers Source Type: research

Antibacterial flavonoids and other compounds from the aerial parts of Vernonia guineensis Benth. (Asteraceae) †.
Antibacterial flavonoids and other compounds from the aerial parts of Vernonia guineensis Benth. (Asteraceae)†. Chem Biodivers. 2020 Jul 13;: Authors: Kouam SF, Wouamba SCN, Happi GM, Pouofo MN, Tchamgoue J, Longo F, Jouda JB, Lenta BN, Sewald N Abstract An extensive phytochemical study of the aerial parts of Vernonia guineensis Benth. (Asteraceae) led to the isolation of a new flavone, vernoguinoflavone (1) and a naturally isolated glycerol ester, bisarachidicester (2), together with eighteen known secondary metabolites including quercetin (3), luteolin (4), vernopicrin (5), vernomelitensin (6...
Source: Chemistry and Biodiversity - July 13, 2020 Category: Biochemistry Authors: Kouam SF, Wouamba SCN, Happi GM, Pouofo MN, Tchamgoue J, Longo F, Jouda JB, Lenta BN, Sewald N Tags: Chem Biodivers Source Type: research

Chemical Components and Antibacterial Activity of the Essential Oil of Six Pyrrosia Species.
Abstract The present study was aimed at analyzing the chemical components of the essential oil from six Pyrrosia species by GC-MS and evaluate their in vitro antibacterial activities. Seventy volatile compounds were identified in the essential oil of six Pyrrosia samples. The identified volatile components were divided into the following nine categories: aldehydes, terpenoids, fatty acids, ketone, furans, hydrocarbons, alcohols, esters, and phenols. The major components of the essential oil were 2,4-pentadienal, phytol and nonanal. The antimicrobial assays showed that the essential oils from Pyrrosia samples exhib...
Source: Chemistry and Biodiversity - July 11, 2020 Category: Biochemistry Authors: Gao D, Fan Y, Feng H, Liu L, Zhang Y, Xin X Tags: Chem Biodivers Source Type: research

Resveratrol and celastrol loaded Collagen dental implants regulate periodontal ligament fibroblast growth and osteoclastogenesis of bone marrow macrophages.
Abstract Collagen is widely used for dental therapy in several ways such as films, 3D matrix, and composites, besides traditional Chinese medicine (TCM) has been used in tissue regeneration and wound healing application for centuries. Hence, the present study was targeted for the first time to fabricate collagen film with TCM such as resveratrol and celastrol in order to investigate the human periodontal ligament fibroblasts (HPLF) growth and bone marrow macrophages (BMM) derived osteoclastogenesis. Further, the physicochemical, mechanical and biological activities of collagen-TCMfilms crosslinked by glycerol and ...
Source: Chemistry and Biodiversity - July 10, 2020 Category: Biochemistry Authors: Wu W, Wang R, Bao B, Bao C, Wang S, Rahman SU, Hou C, Elango J Tags: Chem Biodivers Source Type: research

Optimization of insecticidal triterpene derivatives by biomimetic oxidations with hydrogen peroxide and iodosobenzene catalysed by MnIII and FeIII porphyrin complexes.
ina M Abstract Semisynthetic functionalized triterpenes ( 1 , 3β-acetoxy-8a,9a-epoxy-4a,14a-dimethyl-5a-cholestane; 2 , 4α,14α-dimethyl-5α-cholest-8-ene-3,7,11-trione; 3 , 4α,14α-dimethyl-5α-cholesta-7,9-dien-3-one and 4 , 3β-acetoxy-4a,14a-dimethyl-5a-cholest-8-ene), previously prepared from 31-norlanostenol, a natural insecticide isolated from Euphorbia officinarum latex, have been subjected to oxidation with hydrogen peroxide (H 2 O 2 ) and iodosobenzene (PhIO) catalyzed by porphyrin complexes (cytochrome P-450 models) in order to obtain optimized derivatives with h...
Source: Chemistry and Biodiversity - July 9, 2020 Category: Biochemistry Authors: Mazoir N, Benharref A, Vaca L, González-Coloma A, Reina M Tags: Chem Biodivers Source Type: research

Enriched terpenes fractions of Euphorbia umbellata latex promote apoptosis in leukemic cells.
Abstract The current study was carried out by a bioguided-fractionation of a hexane extract of Euphorbia umbellata latex against leukemic cells. Samples were analyzed by NMR, GC-MS, triterpenes quantification, and MTT reduction assay. Morphological, cell cycle, mitochondrial membrane potential and caspases 3/7 analyses were performed for the dichloromethane and ethanol fractions, and selectivity index for the dichloromethane fraction. NMR analysis presented characteristic signals of terpenes and steroids, data were confirmed by the quantification of triterpenes and GC-MS analysis. MTT reduction assay demonstrated ...
Source: Chemistry and Biodiversity - July 9, 2020 Category: Biochemistry Authors: Cruz LS, Kanunfre CC, de Andrade EA, de Oliveira AA, Cruz LS, de Faria Moss M, Sassaki GL, Alencar Menezes LR, Wang M, Khan IA, Beltrame FL Tags: Chem Biodivers Source Type: research

Water Soluble Coumarin Quaternary Ammonium Chlorides: Synthesis and Biological Evaluation.
;akır Ü Abstract In the present study, coumarin-bearing three pyridinium and three tetra-alkyl ammonium salts were synthesized. The compounds were fully characterized by 1H and 13C NMR, LC-MS and IR spectroscopic methods and elemental analyses. The cytotoxic properties of all compounds were tested against human liver cancer (HepG2), human colorectal cancer (Caco-2) and non-cancer mouse fibroblast (L-929) cell lines. Some compounds performed comparable cytotoxicity with standard drug cisplatin. Antibacterial properties of the compounds were tested against gram-negative Escherichia coli and gram-positive Bacil...
Source: Chemistry and Biodiversity - July 8, 2020 Category: Biochemistry Authors: Karataş MO, Noma SAA, Gürses C, Balcıoğlu S, Ateş B, Alıcı B, Çakır Ü Tags: Chem Biodivers Source Type: research

The Effect of Knockdown TIGAR on Apoptotic and Epithelial-Mesenchymal Markers Expression in Doxorubicin-Resistant Non-Small Cell Lung Cancer A549 Cell Line.
AA Abstract Resistance to chemotherapeutic drugs is a critical problem in cancer therapy, but the underlying mechanism has not been fully elucidated.   TP53-induced glycolysis regulatory phosphatase (TIGAR), an important glycolysis and apoptosis regulator, plays a crucial role in cancer cell survival by protecting cells against oxidative stress-induced apoptosis. In the present study, we investigated whether TIGAR is involved in epithelial-mesenchymal transition (EMT) in doxorubicin (DOX)-resistant human non-small cell lung cancer (NSCLC), A549/DOX cells. We found that the expression of TIGAR was s...
Source: Chemistry and Biodiversity - July 8, 2020 Category: Biochemistry Authors: Ağca C, Kırıcı M, Nedzvetsky VS, Gündoğdu R, Tykhomyrov AA Tags: Chem Biodivers Source Type: research

First Extensive Polyphenolic Profile of Erodium cicutarium with Novel Insights to Elemental Composition and Antioxidant Activity.
uez J Abstract Erodium cicutarium is known for its total polyphenolic content, but this work reveals the first highly detailed profile of E. cicutarium , obtained with UHPLC-LTQ OrbiTrap MS 4 and UHPLC-DAD MS/MS techniques. A total of 85 phenolic compounds were identified and 17 constituents quantified. Overall, 25 new compounds were found, which have not yet been reported for the Erodium genera, or the family Geraniaceae. Along with methanolic extracts, the so far poorly investigated water extracts exhibited in vitro antioxidant activity according to all performed assays, including the ferric reducing/antioxidant...
Source: Chemistry and Biodiversity - July 7, 2020 Category: Biochemistry Authors: Ljoljić Bilić V, Gašić U, Milojković-Opsenica D, Nemet I, Rončević S, Kosalec I, Vuković Rodriguez J Tags: Chem Biodivers Source Type: research

Bioherbicide Potential of Eucalyptus saligna Leaf Litter Essential Oil.
as FA Abstract We aimed to evaluate the bioherbicide potential of Eucalyptus saligna leaf litter essential oil, its fractions and major compounds. Six essential oil fractions were obtained by preparative thin-layer chromatography and analyzed by gas chromatography/mass spectrometry. Effects of the oil, its fractions and major compounds (1,8-cineole and/or α-pinene) diluted in aqueous solution were assessed on germination and seedling growth. Recipient species were Lactuca sativa (model), Amaranthus viridis (weed), Eragrostis plana (weed), and Paspalum notatum (forage). The essential oil was more phytotoxic o...
Source: Chemistry and Biodiversity - July 7, 2020 Category: Biochemistry Authors: Silva ER, Igartuburu JM, Overbeck GE, Soares GLG, Macías FA Tags: Chem Biodivers Source Type: research

Chemical composition, antioxidant potential and enzymes inhibitory properties of Globe artichoke by-products.
In this study, chemical composition and in vitro biological activities of artichoke by-products (leaves, floral stems and bracts) issued from two Tunisian varieties were evaluated. Analysis was performed by means of high-performance liquid chromatography with diode array detection coupled to electrospray ionisation mass spectrometric (LC/DAD/ESI-MS). Total phenolic (TPC) and flavonoid (TFC) contents as well as the antioxidant activity conducted by three complementary methods, DPPH, ABTS and FRAP tests, were performed for each sample. Enzyme inhibitory effects against acetylcholinesterase, butyrylcholinesterase and α-...
Source: Chemistry and Biodiversity - July 6, 2020 Category: Biochemistry Authors: Ben Rejeb I, Dhen N, Gargouri M, Boulila A Tags: Chem Biodivers Source Type: research

Radiolytic cyclization products of phloridzin as potent anti-glycation agents.
Abstract The current research examined for radiolytic structure modification and improved bioefficacy of phloridzin by gamma-ray, subsequent to a 50 kGy irradiation dose. Structures of the unusual degraded products phlorocyclin (2), isophlorocyclin (3), and radiophlorisin (4) were determined spectroscopically, by detailed nuclear magnetic resonance (NMR) and mass spectrometry (MS). Additionally, absolute stereochemistry of the novel cyclized phlorocyclin (2) and isophlorocyclin (3) were proposed by circular dichroism (CD) spectrum analysis. Among the compounds tested, phlorocyclin (2) and isophlorocyclin (3) exhib...
Source: Chemistry and Biodiversity - July 5, 2020 Category: Biochemistry Authors: Jeong GH, Kim TH Tags: Chem Biodivers Source Type: research

Design, synthesis, molecular docking, and biological evaluation of new emodin anthraquinone derivatives as potential antitumor substances.
Abstract The emodin anthraquinone derivatives are generally used in traditional Chinese medicine due to their various pharmacological activities. In the present study, a series of emodin anthraquinone derivatives have been designed and synthesized among which 1,3-Dimethoxy-6,8-dihydroxy-anthraquinone ( 11b ) is a natural compound that has been synthesized for the very first time, and 1,3-Dimethoxy-5,8-dimethyl-anthraquinone ( 11c ) is a compound that has never been reported earlier. Interestingly, while total seven of these compounds showed neuraminidase inhibitory activity in influenza virus with inhibition rate ...
Source: Chemistry and Biodiversity - July 5, 2020 Category: Biochemistry Authors: Li Y, Guo F, Chen T, Zhang L, Wang Z, Su Q, Feng L Tags: Chem Biodivers Source Type: research

Synthesis and Evaluation of Anticonvulsant Activity of Schiff Base of 1,4-Benzodiazepine Amine.
Abstract A variety of 1,4-benzodiazepine azomethines (3a-n) and 1,4-benzodiazepine benzamide (4) were prepared, characterized and evaluated for the anticonvulsant activity in the rat using picrotoxin-induced seizure model. The prepared 1,4-benzodiazepine azomethine derivative emerged potentially anticonvulsant molecular scaffolds exemplified by compounds, 7-(4-nitrophenyl)methyleneamino-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one (3c), 7-[4-(dimethylamino)phenyl]methyleneamino-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one (3e), 7-[(4-bromo-2,6-difluoro-phenyl)methyleneamino]-5-phenyl-1,3-dihydro-1,4-benzodiazepin-...
Source: Chemistry and Biodiversity - June 29, 2020 Category: Biochemistry Authors: Gawande MB, Nilkanth PR, Ghorai S, S A, Dhawale K, Shelke S, Ahamad T Tags: Chem Biodivers Source Type: research

Chemical constituents of the Vietnamese marine sponge Gelliodes sp. and their cytotoxic activities.
Abstract A new decenoic acid derivative, gelliodesinic acid ( 1 ), and a natural new indole alkaloid ( 2 ), together with three known furanoterpenoids ( 3 - 5 ) and two known indole alkaloids ( 6 - 7 ), were isolated from the MeOH extract of the marine sponge Gelliodes sp. collected in Vietnam. The chemical structures of 1 - 7 were determined by analyses of 1D- and 2D-NMR and MS data and by comparisons of the data with those reported in the literature. The cytotoxicity assay against HeLa, MCF-7, and A549 cancer cell lines revealed that the known furanoterpenes 3 - 5 exhibited cytotoxic activities, with IC 50 value...
Source: Chemistry and Biodiversity - June 27, 2020 Category: Biochemistry Authors: Ki DW, Kodama T, El-Desoky AH, Wong CP, Nguyen HM, Minh K, Thai QM, Nu LHT, Morita H Tags: Chem Biodivers Source Type: research

Synthesis of Novel Aryloxyethylamine Derivatives and Evaluation of Their in Vitro and in Vivo Neuroprotective Activities.
Abstract A series of aryloxyacetamine derivatives W1 - W37 were designed, synthesized and evaluated for their biological activity. Their structures were confirmed by 1 H-NMR, 13 C-NMR, and HR-ESI-MS. The preliminary screening of neuroprotection of compounds in vitro was detected by MTT, and the anti-ischaemic activity in vivo was tested using bilateral common carotid artery occlusion in Kunming Mice. Most of these compounds showed potent neuroprotective effects against the glutamate-induced cell death in differentiated rat pheochromocytoma cells (PC12 cells), especially for W1 , W7 , W16 , W26 , W28 , W29 and W30 ...
Source: Chemistry and Biodiversity - June 24, 2020 Category: Biochemistry Authors: Zhong Y, Gao Y, Xu Y, Qi C, Wu B Tags: Chem Biodivers Source Type: research

In vitro effects of ginseng and Ziziphi Spinosae Semen on gut microbiota of rats with spleen deficiency.
This study investigated the effects of ginseng and Ziziphi Spinosae Semen ( GS ) extract on gut microbiota diversity in rats with spleen deficiency syndrome ( SDS ). A total of 52 compounds (including 16 flavonoids, 35 saponins, and 1 alkaloid) were identified and analyzed from the GS extract by UPLC-Q-Orbitrap-MS/MS. The GS extract significantly increased the relative abundance of Firmicutes and Bacteroidetes in rats with SDS but decreased that of Proteobacteria and Actinobacteria. At the genus level, the GS extract significantly increased the relative abundance of Lactobacillus and Bifidobacterium in rats with SDS but de...
Source: Chemistry and Biodiversity - June 23, 2020 Category: Biochemistry Authors: Li FT, Yang D, Song FY, Liu M, Dai YL, Zheng F, Yue H Tags: Chem Biodivers Source Type: research

Uncovering biological application of Brazilian green propolis: a phenotypic screening against Schistosoma mansoni.
atilde;es L Abstract The chemotherapy of schistosomiasis remains centered in the use of praziquantel. However, there has been growing resistant parasites to this drug. Thus, the aim of this work was to evaluate in vitro schistosomicidal activity of the hexanes-dichloromethane 1:1 extract of Brazilian green propolis (Pex), as well as its major isolated compounds artepillin C ( 1 ), caffeic acid ( 2 ), coumaric acid ( 3 ) and drupanin ( 4 ) against Schistosoma mansoni . The Pex was active by displaying IC 50 value of 36.60 (26.26-51.13) µg.mL -1 at 72 h against adult worms of S. mansoni . The major isolated co...
Source: Chemistry and Biodiversity - June 23, 2020 Category: Biochemistry Authors: de L Paula LA, Santos MF, Pagotti MC, Faleiros R, Ramos HP, Veneziani RC, Bastos JK, Caffrey CR, Ambrósio SR, Guidi Magalhães L Tags: Chem Biodivers Source Type: research

Sequences of Tolypins, Insecticidal Efrapeptin-Type Peptaibiotics from Species of the Fungal Genus Tolypocladium.
b T Abstract A peptide mixture named tolypin, originally isolated from species of the fungal genus Tolypocladium, was structurally characterised and sequences compared to those reported for efrapeptins isolated from strains of Tolypocladium inflatum. Chiral amino acid analysis, direct infusion, and online HPLC electrospray ionization tandem mass spectrometry provided composition, molecular weights of peptides, and series of diagnostic fragment ions. Sequences deduced from ESI-MS revealed that tolypins C-G are identical to efrapeptins C-G. The results were corroborated by ESI-MS and HPLC of an authentic efrapeptin ...
Source: Chemistry and Biodiversity - June 23, 2020 Category: Biochemistry Authors: Brückner H, Degenkolb T Tags: Chem Biodivers Source Type: research

Design, synthesis and in vitro evaluation of tylophorine derivatives as possible anti-tumor agents.
Abstract Structural simplification and modification of natural products is always a very important resource to find anti-tumor drugs. By introducing various amino methyl groups and amide groups into phenanthrene ring of tylophorine, a novel seriesof tylophorine derivatives have been designed and synthesized. And their anti-proliferative activities against MCF-7, A549 and HepG-2 cells have been evaluated too. The results indicated that most of the prepared compounds exhibited good anti-tumor activities. Especially, compound AF-012 with an N -ethyl-2-morpholinoethanamine methyl group at the side chain of phenanthren...
Source: Chemistry and Biodiversity - June 22, 2020 Category: Biochemistry Authors: Mang Z, Zhang S, Bai J, Li M, Li H Tags: Chem Biodivers Source Type: research

Recent Advances on Marine Alkaloids from Sponges.
Abstract Alkaloids from marine secondary metabolites have received extensive attention from pharmacists in recent years. Miscellaneous alkaloids derived from marine sponges possessed various pharmacological activities including cytotoxicity, antimicrobial, antioxidant, and so on. Herein, we summarized 149 marine alkaloids from sponges based on their structures and bioactivities reported from 2015 to 2020, and analyzed the production environment of marine sponges with rich alkaloids. Moreover, we discussed biosynthesis routes of pyrrole and guanidine alkaloids from marine sponges Agelas and Monanchora . This paper ...
Source: Chemistry and Biodiversity - June 20, 2020 Category: Biochemistry Authors: Wu W, Bian C, Zhou X, Wang J, Guo R Tags: Chem Biodivers Source Type: research

Extracts and steroids from the edible mushroom Hypholoma lateritium exhibit anti-inflammatory properties by inhibition of COX-2 and activation of Nrf2.
Abstract Hypholoma lateritium is an edible macrofungus with a common distribution in Europe, North America, and the Far East. The aim of this study was to investigate the potential anti-inflammatory effects of H. lateritium extracts and its isolated steroids: fasciculic acid B (1), fasciculol E (2), fasciculol C (3), lanosta-7,9(11)-diene-12β,21α-epoxy-2α,3β,24β,25-tetraol (4), fasciculol F (5), and demethylincisterol A2 ( 6 ). Organic ( n -hexane, chloroform and 50% methanol) and water extracts of H. lateritium were subjected to in vitro assays to determine pro-inflammatory protein leve...
Source: Chemistry and Biodiversity - June 19, 2020 Category: Biochemistry Authors: Vanyolos A, Muszyńska B, Chuluunbaatar B, Gdula-Argasińska J, Kała K, Hohmann J Tags: Chem Biodivers Source Type: research

Total Tocopherols, Carotenoids, and Fatty acids Contents Variation of Pistacia atlantica Desf Different Organs Crude Oils and their Antioxidant Activity during Development Stages.
Abstract The current study investigated the effect of developmental stages on the chemical composition and the antioxidant activity of fifteen crude oil samples obtained from Pistacia atlantica Desf leaves, galls, and fruits. Twelve fatty acids were detected by GC/FID, linolenic acid (C18:3) was the major fatty acid detected in leaves crude oils that registered [41.73 % ( P ˂ 0.05)] on the last stage. The best content of tocopherols and carotenoids was recorded at the last stage for leaves and galls oils respectively, with values of [1.530 ± 0.01, 0.52 ± 0.01 ( P ˂ 0.05) mg α-tocopherol equiv...
Source: Chemistry and Biodiversity - June 17, 2020 Category: Biochemistry Authors: Chelghoum M, Guenane H, Harrat M, Yousfi M Tags: Chem Biodivers Source Type: research

Bioassay-Guided Fractionation, Chemical Compositions and Antibacterial Activity of Extracts from Rhizomes of  Globba schomburgkii Hook.f.
Bioassay-Guided Fractionation, Chemical Compositions and Antibacterial Activity of Extracts from Rhizomes of Globba schomburgkii Hook.f. Chem Biodivers. 2020 Jun 15;: Authors: Suekaew N, Na Pombejra S, Kulsing C, Doungchawee J, Khotavivattana T Abstract Bioassay-guided fractionation was conducted on dichloromethane extract from the rhizomes of Globba schomburgkii Hook.f. which have previously been reported as the part with the highest antibacterial activity. 10 fractions and 20 sub-fractions were obtained and evaluated for their potency against various strains of bacteria. The most active sub-fra...
Source: Chemistry and Biodiversity - June 15, 2020 Category: Biochemistry Authors: Suekaew N, Na Pombejra S, Kulsing C, Doungchawee J, Khotavivattana T Tags: Chem Biodivers Source Type: research

Phloroglucinol Derivatives from Myrtus communis 'Variegata' and Their Antibacterial Activities.
Abstract M yrtucomvalones D-F ( 1 - 3 ), three new triketone-phloroglucinol-triketone adduct s, and three known ones ( 4 - 6 ) were obtained from Myrtus communis 'Variegata'. Compound 1 is a pair of enantiomers which was further resolved into (+)- 1 and (-)- 1 by chiral HPLC. Their structures and complete stereochemistry were established from interpretation of NMR and crystallographic data and chemical calculations. Compounds 3 , 5 and 6 showed significant antibacterial activities. PMID: 32539173 [PubMed - as supplied by publisher] (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - June 15, 2020 Category: Biochemistry Authors: Wu Y, Chen M, Wang WJ, Li NP, Ye WC, Wang L Tags: Chem Biodivers Source Type: research

Antibacterial Mechanism of Curcumin: A Review.
Abstract Curcumin is a plant-derived polyphenolic active substance with broad-spectrum antibacterial properties. Curcumin blocks bacterial growth owing to its structural characteristics and the generation of anti-oxidation products. Curcumin can inhibit bacterial virulence factors, inhibit bacterial biofilm formation and prevent bacterial adhesion to host receptors through the bacterial quorum sensing regulation system. As a photosensitizer, curcumin acts under blue light irradiation to induce phototoxicity and inhibit bacterial growth. Moreover, it can exert a synergistic antibacterial effect with other antibacte...
Source: Chemistry and Biodiversity - June 13, 2020 Category: Biochemistry Authors: Zheng D, Huang C, Huang H, Zhao Y, Khan MRU, Zhao H, Huang L Tags: Chem Biodivers Source Type: research

Accumulation of minerals by Leccinum scabrum from two large forested areas in Central Europe: Notecka Wilderness and Tuchola Forest (Pinewoods).
Abstract Leccinum scabrum sporocarps and associated topsoils from two areas in Poland have been characterized for contents and bioconcentration potential of Ag, Al, Ba, Ca, Cd, Co, Cu, Fe, Hg, K, Mg, Mn, Na, Ni, P, Pb, Rb, Sr and Zn. Topsoil and fruitbody element composition varied between the two study sites, most likely as a result of local soil geochemistry. Element content of the labile fraction in topsoil from both sites followed the "pseudo-total" fraction and median values (mg kg-1 dry matter) were: K 380 and 340, Mg 760 and 840, P 1100 and 920, Al 3800 and 8100, Ag 0.31 and 0.28, Ba 28 and 37, Ca...
Source: Chemistry and Biodiversity - June 12, 2020 Category: Biochemistry Authors: Falandysz J, Mędyk M, Treu R Tags: Chem Biodivers Source Type: research

Antiproliferative effect and cell cycle alterations induced by Salvia officinalis essential oil and its three main components in human colon cancer cell lines.
In this study we elucidated the antiproliferative properties and the effect on cell cycle progression of sicilian Salvia officinalis essential oil and its three main compounds on three human colon cancer cell lines. The essential oil was extracted by hydrodistillation and analysed by gas chromatography. Cell proliferation was evaluated by MTT assay, and the cell cycle distribution was determined by flow cytometry. Thirty-four compounds were identified in the tested essential oil. Thirty-four compounds were identified in the tested essential oil. Growth inhibition was observed after 72 h, with an impact on cell cycle progre...
Source: Chemistry and Biodiversity - June 12, 2020 Category: Biochemistry Authors: Luca T, Napoli E, Privitera G, Musso N, Ruberto G, Castorina S Tags: Chem Biodivers Source Type: research

Antioxidant, antimicrobial and anti-inflammatory activities of essential oil derived from the wild rhizome of Atractylodes macrocephala Koidz.
Abstract The present study investigated the chemical composition, antioxidant, antimicrobial, and anti-inflammatory activities of essential oil (EO) derived from the wild rhizomes of Atractylodes macrocephala Koidz (AMA) growing in Qimen County (eastern China). GC-MS analysis identified fifteen compounds, representing 92.55% of AMA EO. The major compounds were atractylone (39.22%), β -eudesmol (27.70%), thymol (5.74%), hinesol (5.50%), and 11-Isopropylidenetricyclo [4.3.1.1(2,5)] undec-3-en-10-one (4.71%). Ferricyanide reducing, 1,1-diphenyl-2-picyrlhydrazyl (DPPH) and 3-ethyl-benzothiazoline-6-sulfonic acid ...
Source: Chemistry and Biodiversity - June 12, 2020 Category: Biochemistry Authors: Wu YX, Lu WW, Geng YC, Yu CH, Sun HJ, Kim YJ, Zhang G, Kim T Tags: Chem Biodivers Source Type: research

Hexokinase II Inhibitory Effect of Secondary Metabolites Derived from a Streptomyces sp. Associated with Mud Dauber Wasp.
In this study, chemical examination of a Streptomyces sp. associated with a mud dauber wasp led to the isolation of fourteen compounds. Their structures were determined by spectroscopic methods and comparison with literature data. Among the isolates, compounds 1,2,3-benzotriazin-4(1H)-one and 4-(2-aminoethyl)phenyl acetate were first reported from this species. Bioactivities of the isolated compounds were assayed for the first time against hexokinase II. 4-(2-Aminoethyl)phenyl acetate, germicidin B, phenylacetic acid, isogermicidin A and germicidin C displayed significant inhibitory activity against hexokinase II, with the...
Source: Chemistry and Biodiversity - June 9, 2020 Category: Biochemistry Authors: Zhang XM, Peng AH, Xie WD, Wang M, Zheng D, Feng MK Tags: Chem Biodivers Source Type: research

Phytochemical and biological characterization of methanolic extracts from Rumex algeriensis and Rumex tunetanus.
In conclusion, R. algeriensis and R. tunetanus have shown to be potential sources of bioactive products to be used in the prevention and treatment of pathologies related to oxidative stress and inflammation. PMID: 32501568 [PubMed - as supplied by publisher] (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - June 5, 2020 Category: Biochemistry Authors: Abidi J, Occhiuto C, Cimino F, Speciale A, Ruberto G, Siracusa L, Bouaziz M, Boumendjel M, Muscarà C, Saija A, Cristani M Tags: Chem Biodivers Source Type: research

Synthesis, Characterization, Molecular docking, and Biological Activities of Some Natural and Synthetic Urolithin Analogues.
Abstract Urolithins (i.e., hydroxyl substituted benzo[c]chromen-6-one derivatives) are formed within the gastrointestinal tract following to the exposure to various ellagitannin rich diet, particularly involving pomegranate, nuts, and berries. Regarding the bioavailability deficiency of ellagitannins, the biological activities obtained through the extracts of these dietaries are attributed to the urolithin compounds, since they are bioavailable. Particularly, there are studies indicating the importance of ellagitannin rich food for protective and alternative treatment of Alzheimer's Disease (AD). From this perspec...
Source: Chemistry and Biodiversity - June 4, 2020 Category: Biochemistry Authors: Gulcan HO, Noshadi B, Ercetin T, Luise C, Yuksel MY, Sippl W, Sahin MF, Gazi M Tags: Chem Biodivers Source Type: research

< p > Ansavaricin J, a New < a href="https://cn.bing.com/academic/profile?id=d9e2d477eec90ff106788fe4cb08f938 & amp;encoded=0 & amp;v=paper_preview & amp;mkt=zh-cn" target="_blank" > Heterocyclic & nbsp;Ring-fused & nbsp; < /a > Streptovaricin from Gene < em > stvP5 < /em > -deleted Mutant of < em > Streptomyces spectabilis < /em > CCTCC M2017417 < /p > .
Ansavaricin J, a New Heterocyclic&nbsp;Ring-fused&nbsp;Streptovaricin from Gene stvP5-deleted Mutant of Streptomyces spectabilis CCTCC M2017417. Chem Biodivers. 2020 Jun 03;: Authors: Liu Y, Chen X, Li ZY, Huang LX, Sun YH Abstract A new ring-fused streptovaricin analogue, named ansavaricin J ( 1 ), together with the known compound ansavaricin E, were unprecedently isolated from the culture of the genetically modified strains ΔstvP5 and ΔstvP4 which derived from Streptomyces spectabilis CCTCC M2017417, respectively. Their structures were elucidated via comprehensive spectroscopic a...
Source: Chemistry and Biodiversity - June 3, 2020 Category: Biochemistry Authors: Liu Y, Chen X, Li ZY, Huang LX, Sun YH Tags: Chem Biodivers Source Type: research

​ A series of benzylidene linked to hydrazinecarbothioamide as tyrosinase inhibitors Synthesis, biological evaluation and structure-activity relationship.
Abstract Tyrosinase is a type 3 copper enzyme responsible for skin pigmentation disorders, skin cancer, and enzymatic browning of vegetables and fruits. In the present article, 12 small molecules of benzylidene-hydrazinecarbothioamide were designed, synthesized and evaluated for their anti-tyrosinase activities followed by molecular docking and pharmacophore-based screening. Among synthesized thiosemicarbazone derivatives, 3d is the strongest inhibitor of mushroom tyrosinase with IC 50 of 0.05 µM which demonstrated a 128 fold increase in potency compared to the positive control. Kinetic studies also revealed...
Source: Chemistry and Biodiversity - June 1, 2020 Category: Biochemistry Authors: Hosseinpoor H, Iraji A, Edraki N, Pirhadi S, Attarroshan M, Khoshneviszadeh M, Khoshneviszadeh M Tags: Chem Biodivers Source Type: research

Naphthalenones and naphthols isolated from the Saussurea laniceps endophytic fungus Didymella glomerate X223.
Abstract One new naphthalenone, didymelol A (1), and three new naphthols, didymelol B-D (5-7), together with three known naphthalenones, (3S,4R)-3,4,6,8-tetrahydroxy-3,4-dihydronaphthalen-1(2H)-one (2), (S)-4,6,8-trihydroxy-3,4-dihydronaphthalen-1(2H)-one (3), (S)-4,8-dihydroxy-3,4-dihydronaphthalen-1(2H)-one (4), were isolated from the Saussurea laniceps endophytic fungus Didymella glomerate X223. The structures of the isolates were elucidated based on extensive spectroscopic data analysis. The absolute configuration of didymelol A (1) was established through single-crystal X-ray diffraction data and didymelols B...
Source: Chemistry and Biodiversity - May 30, 2020 Category: Biochemistry Authors: Luo G, Chen S, Yu J, Yuan J, Zheng L, Liu L, Chen B, Li J Tags: Chem Biodivers Source Type: research

Investigation of the effects of squalene and squalene epoxides on the homeostasis of coenzyme Q10 in rats by UPLC-Orbitrap MS.
Abstract Squalene has been used as a dietary supplement for a long history due to its potential cancer-preventive function. However, the mechanism has not yet been investigated in detail. Therefore, the aim of this study is to see if the plasma coenzyme Q 10 (CoQ 10 ) level will be altered by gavage of squalene and oxidosqualenes to rats. In the present work, a sensitive and simple high-performance analytical method based on ultra-high-performance liquid chromatography coupled with an Orbitrap mass spectrometry (UPLC-Orbitrap-MS) was developed for the quantification of CoQ 10 in rat plasma. Coenzyme Q 9 (CoQ 9 ) w...
Source: Chemistry and Biodiversity - May 29, 2020 Category: Biochemistry Authors: Yang H, Yu W, Sun K, Zhang L, Chen C, Su R, Liu S, Wang H, Liu Y Tags: Chem Biodivers Source Type: research

Chemical diversity of volatile compounds of mints from southern part of Pannonian plain and Balkan Peninsula - new data.
Abstract Mints are the most popular economic and traditional herbs. The aim of this paper was chemical characterization of volatile compounds from wild populations of Mentha aquatica , M . arvensis , M . longifolia , M . microphylla, M . pulegium , M . spicata , M . × dumetorum , M . × gentillis and M . × verticillata , as well as cultivated samples of M . spicata , M . × piperita 'Alba' and M . × piperita 'Crispa'. Analyses were performed directly from dried aerial parts (herb) of collected samples by Headspace Gas Chromatography - Mass Spectrometry. In total 54 compounds were detect...
Source: Chemistry and Biodiversity - May 29, 2020 Category: Biochemistry Authors: Bokić B, Rat MM, Kladar NV, Anačkov GT, Božin BN Tags: Chem Biodivers Source Type: research

Exploring MDR-TB inhibitory potential of 4-amino quinazolines as Mycobacterium tuberculosis N -acetylglucosamine-1-phosphate uridyltransferase (GlmU MTB) inhibitors.
Abstract Drug resistance tuberculosis is one of the challenging tasks that dictates the desperate need for the development of new anti-tubercular agents which operate via novel modes of action. Here, we are reporting the 4-amino quinazolines as M. tuberculosis N -acetylglucosamine-1-phosphate uridyltransferase (GlmU MTB) inhibitors to overcome the problem of the MDR-TB. Amongst the synthesized compounds HMP-05 and HMP-15 was observed to be the effective compound of the series [IC 50 = 6.4 µM (H37Rv), MIC = 25 µM (MDR-TB) and IC 50 = 2.9 µM (H37Rv), MIC = 6.25 µM (MDR-TB) respectively]. ...
Source: Chemistry and Biodiversity - May 29, 2020 Category: Biochemistry Authors: Patel H, Karpoormath R, Palkar M Tags: Chem Biodivers Source Type: research

The binding ability of bicyclic somatostatin analogue towards Cu(II) ions.
Abstract Somatostatin (SST) analogues have aroused the interest of scientists for years. This group of compounds is used in the diagnosis and treatment of neuroendocrine tumors. However, new molecules useful as radiopharmaceuticals in targeted therapy are still searched for. Bicyclic peptides seem to be very interesting in this context. These molecules are associated with beneficial properties. In this work, we present studies on the binding ability of the bicyclic analogue of somatostatin toward copper(II) ions which could potentially be a chelator for copper radionuclides. The research is focused on the analysis...
Source: Chemistry and Biodiversity - May 29, 2020 Category: Biochemistry Authors: Marciniak A, Witak W, Pieniężna A, Brasun J Tags: Chem Biodivers Source Type: research