Essential Oils of Six Achillea Species: Chemical Profiles, Antimicrobial Potential and Toxicity toward Crustaceans
Chem Biodivers. 2022 Jan 13. doi: 10.1002/cbdv.202100905. Online ahead of print.ABSTRACTThis is the first comparative study on antimicrobial activity of essential oils (EOs) of six Achillea species ( A. crithmifolia , A. distans , A. grandifolia , A. millefolium , A. nobilis , and A. lingulata ) against ATCC and clinical microbial strains isolated from human swabs and on their toxicological potential on crustaceans. Oxygenated monoterpenes represented the major compound class in all six EOs, ranging from around 50% ( A. millefolium , A. nobilis , and A. lingulata ) up to over 80% ( A . crithmifolia and A. grandifolia ). Sp...
Source: Chemistry and Biodiversity - January 13, 2022 Category: Biochemistry Authors: Jelena P Stojanovi ć Gordana S Stojanovi ć Zorica Z Stojanovi ć-Radić Bojan K Zlatkovi ć Jovana D Ickovski Ivana G Zlatanovi ć Sne žana Č Jovanović Zorica S Miti ć Source Type: research

Undescribed Anti-inflammatory Thalysiaketides from Marine Sponge Clathria (Thalysias) vulpina (Lamarck, 1814)
Chem Biodivers. 2022 Jan 13. doi: 10.1002/cbdv.202100838. Online ahead of print.ABSTRACTTwo undescribed polyketide type compounds, thalysiaketide A and thalysiaketide B were isolated from a sponge of marine origin Clathria (Thalysias) vulpina (Lamarck, 1814). Thalysiaketide A exhibited significantly greater inhibitory potential against inflammatory 5-lipoxygenase (IC50 0.87 mM) and cyclooxygense-2 (IC50 0.93 mM) compared to those revealed by its thalysiaketide B analogue (IC50 ≥ 1.05 mM). The 5-lipoxygenase inhibitory activity of thalysiaketide A was considerably superior to ibuprofen (standard, IC50> 4 mM). Higher d...
Source: Chemistry and Biodiversity - January 13, 2022 Category: Biochemistry Authors: Prima Francis Kajal Chakraborty Source Type: research

Essential Oils of Six Achillea Species: Chemical Profiles, Antimicrobial Potential and Toxicity toward Crustaceans
Chem Biodivers. 2022 Jan 13. doi: 10.1002/cbdv.202100905. Online ahead of print.ABSTRACTThis is the first comparative study on antimicrobial activity of essential oils (EOs) of six Achillea species ( A. crithmifolia , A. distans , A. grandifolia , A. millefolium , A. nobilis , and A. lingulata ) against ATCC and clinical microbial strains isolated from human swabs and on their toxicological potential on crustaceans. Oxygenated monoterpenes represented the major compound class in all six EOs, ranging from around 50% ( A. millefolium , A. nobilis , and A. lingulata ) up to over 80% ( A . crithmifolia and A. grandifolia ). Sp...
Source: Chemistry and Biodiversity - January 13, 2022 Category: Biochemistry Authors: Jelena P Stojanovi ć Gordana S Stojanovi ć Zorica Z Stojanovi ć-Radić Bojan K Zlatkovi ć Jovana D Ickovski Ivana G Zlatanovi ć Sne žana Č Jovanović Zorica S Miti ć Source Type: research

Undescribed Anti-inflammatory Thalysiaketides from Marine Sponge Clathria (Thalysias) vulpina (Lamarck, 1814)
Chem Biodivers. 2022 Jan 13. doi: 10.1002/cbdv.202100838. Online ahead of print.ABSTRACTTwo undescribed polyketide type compounds, thalysiaketide A and thalysiaketide B were isolated from a sponge of marine origin Clathria (Thalysias) vulpina (Lamarck, 1814). Thalysiaketide A exhibited significantly greater inhibitory potential against inflammatory 5-lipoxygenase (IC50 0.87 mM) and cyclooxygense-2 (IC50 0.93 mM) compared to those revealed by its thalysiaketide B analogue (IC50 ≥ 1.05 mM). The 5-lipoxygenase inhibitory activity of thalysiaketide A was considerably superior to ibuprofen (standard, IC50> 4 mM). Higher d...
Source: Chemistry and Biodiversity - January 13, 2022 Category: Biochemistry Authors: Prima Francis Kajal Chakraborty Source Type: research

Scalable Syntheses and Biological Evaluation of Africane-type  Sesquiterpenoids
Chem Biodivers. 2022 Jan 12. doi: 10.1002/cbdv.202100890. Online ahead of print.ABSTRACTPractical total syntheses of africane-type sesquiterpenoids were realized by reexamination of a divergent strategy employing optimized three-component coupling followed by ring-closing metathesis and substrate-controlled cyclopropanation. This sequential eight-step conversion provided Δ9(15)-africanene, a common bicyclo[5.3.0]decane intermediate for the syntheses of africane derivatives, in more than twice the yield as in the previous approach. The scalability and robustness of this improved synthetic route were confirmed by gram-...
Source: Chemistry and Biodiversity - January 12, 2022 Category: Biochemistry Authors: Yutaka Matsuda Takayuki Koyama Sayaka Kawano Kazuki Miura Siro Simizu Yoko Saikawa Masaya Nakata Source Type: research

Synthesis, biological evaluation and in silico studies of new pyrazoline derivatives bearing benzo[d]thiazol-2(3H)-one moiety as potential urease inhibitors
Chem Biodivers. 2022 Jan 12. doi: 10.1002/cbdv.202100826. Online ahead of print.ABSTRACTNovel pyrazoline derivatives containing benzo[d]thiazol-2(3H)-one moiety were synthesized and screened for their inhibitory properties against to urease, a clinically important metabolic enzyme. In vitro enzyme inhibition studies revealed that all pyrazolines (7.21-87.77 µM) were more potent than the standard inhibitor acetohydroxamic acid (251.74 µM) against the urease enzyme. Most notably, compound 2m , which is more active than the other compounds in in vitro and molecular docking studies, showed a significant inhibition ...
Source: Chemistry and Biodiversity - January 12, 2022 Category: Biochemistry Authors: Fatih Tok Nimet Balta ş Gizem Tatar Bedia Ko çyiğit-Kaymakçıoğlu Source Type: research

Antischistosomal Activity of Essential Oils: An Updated Review
Chem Biodivers. 2022 Jan 12. doi: 10.1002/cbdv.202100909. Online ahead of print.ABSTRACTThis review article covers literature on the antischistosomal activity of essential oils (EOs)( between 2011 and 2021. Criteria for classifying results from in vitro schistosomicidal assays are proposed for the first time. Parameters to evaluate the in vitro antischistosomal potential of EOs other than their ability to cause the death of Schistosoma mansoni adult worms ( e.g ., couple separation, egg laying, and egg development inhibition) are also addressed and discussed.PMID:35020262 | DOI:10.1002/cbdv.202100909 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - January 12, 2022 Category: Biochemistry Authors: Antonio Crotti Mariana C Pagotti Lizandra G Magalh ães Thais Miller Oliveira Source Type: research

Scalable Syntheses and Biological Evaluation of Africane-type  Sesquiterpenoids
Chem Biodivers. 2022 Jan 12. doi: 10.1002/cbdv.202100890. Online ahead of print.ABSTRACTPractical total syntheses of africane-type sesquiterpenoids were realized by reexamination of a divergent strategy employing optimized three-component coupling followed by ring-closing metathesis and substrate-controlled cyclopropanation. This sequential eight-step conversion provided Δ9(15)-africanene, a common bicyclo[5.3.0]decane intermediate for the syntheses of africane derivatives, in more than twice the yield as in the previous approach. The scalability and robustness of this improved synthetic route were confirmed by gram-...
Source: Chemistry and Biodiversity - January 12, 2022 Category: Biochemistry Authors: Yutaka Matsuda Takayuki Koyama Sayaka Kawano Kazuki Miura Siro Simizu Yoko Saikawa Masaya Nakata Source Type: research

Synthesis, biological evaluation and in silico studies of new pyrazoline derivatives bearing benzo[d]thiazol-2(3H)-one moiety as potential urease inhibitors
Chem Biodivers. 2022 Jan 12. doi: 10.1002/cbdv.202100826. Online ahead of print.ABSTRACTNovel pyrazoline derivatives containing benzo[d]thiazol-2(3H)-one moiety were synthesized and screened for their inhibitory properties against to urease, a clinically important metabolic enzyme. In vitro enzyme inhibition studies revealed that all pyrazolines (7.21-87.77 µM) were more potent than the standard inhibitor acetohydroxamic acid (251.74 µM) against the urease enzyme. Most notably, compound 2m , which is more active than the other compounds in in vitro and molecular docking studies, showed a significant inhibition ...
Source: Chemistry and Biodiversity - January 12, 2022 Category: Biochemistry Authors: Fatih Tok Nimet Balta ş Gizem Tatar Bedia Ko çyiğit-Kaymakçıoğlu Source Type: research

Antischistosomal Activity of Essential Oils: An Updated Review
Chem Biodivers. 2022 Jan 12. doi: 10.1002/cbdv.202100909. Online ahead of print.ABSTRACTThis review article covers literature on the antischistosomal activity of essential oils (EOs)( between 2011 and 2021. Criteria for classifying results from in vitro schistosomicidal assays are proposed for the first time. Parameters to evaluate the in vitro antischistosomal potential of EOs other than their ability to cause the death of Schistosoma mansoni adult worms ( e.g ., couple separation, egg laying, and egg development inhibition) are also addressed and discussed.PMID:35020262 | DOI:10.1002/cbdv.202100909 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - January 12, 2022 Category: Biochemistry Authors: Antonio Crotti Mariana C Pagotti Lizandra G Magalh ães Thais Miller Oliveira Source Type: research

Protective effects of chrysin against cyclophosphamide-induced cardiotoxicity in rats: A biochemical and histopathological approach
This study evaluated the protective properties of Chy against CyC-induced cardiotoxicity in rats. The animals were orally treated with Chy (25 and 50 mg/kg/day) for 35 days and exposed to CyC (i.p., 100 mg/kg) once a week for four weeks. The results indicated that CyC caused significant cardiotoxicity as manifested by notable increases in heart weight, cardiac function biomarkers such as lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), troponin T and aspartate transaminase (AST). In addition, cardiac malondialdehyde (MDA), tumor necrosis factor alpha (TNF-α), interleukin 1β (IL1 β) and interleukin 6...
Source: Chemistry and Biodiversity - January 11, 2022 Category: Biochemistry Authors: Bin Ye Wenchao Ling Yinhua Wang Amit Jaisi Opeyemi Joshua Olatunji Source Type: research

Polyphenol Contents, Potential Antioxidant, Anticholinergic and Antidiabetic Properties of Mountain Mint (Cyclotrichium leucotrichum)
This study will be useful for future studies to determine the antioxidant properties and enzyme inhibition profile of food, medical and industrially important plants.PMID:35015378 | DOI:10.1002/cbdv.202100775 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - January 11, 2022 Category: Biochemistry Authors: Ilhami Gulcin Zeynebe Bing öl Parham Taslimi Ahmet C G ören Saleh H Alwasel Ahmet Zafer Tel Source Type: research

Protective effects of chrysin against cyclophosphamide-induced cardiotoxicity in rats: A biochemical and histopathological approach
This study evaluated the protective properties of Chy against CyC-induced cardiotoxicity in rats. The animals were orally treated with Chy (25 and 50 mg/kg/day) for 35 days and exposed to CyC (i.p., 100 mg/kg) once a week for four weeks. The results indicated that CyC caused significant cardiotoxicity as manifested by notable increases in heart weight, cardiac function biomarkers such as lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), troponin T and aspartate transaminase (AST). In addition, cardiac malondialdehyde (MDA), tumor necrosis factor alpha (TNF-α), interleukin 1β (IL1 β) and interleukin 6...
Source: Chemistry and Biodiversity - January 11, 2022 Category: Biochemistry Authors: Bin Ye Wenchao Ling Yinhua Wang Amit Jaisi Opeyemi Joshua Olatunji Source Type: research

Phytochemical contents of different parts of the seeded raisins from the South-East Anatolia: Enzyme inhibitory potential of pulp extracts
In this study, some phytochemical properties of six seeded raisin species that are mainly cultivated in Southeastern Anatolia were investigated. Additionally, some physical and quality characteristics, phenolic contents (by LC-MS/MS; Liquid Chromatography Tandem Mass / Mass Spectrometer System), anticholinesterase, and antioxidant capacities (DPPH; 2,2-diphenyl-1-picrylhydrazyl free-radical scavenging, ABTS; 2,2-azinobis-(3-ethylbenzothiazoline-6-sulphonic acid cation-radical scavenging activity and CUPRAC; cupric reducing antioxidant capacity) of the cultivars were investigated on ground raisins. In all three methods, the...
Source: Chemistry and Biodiversity - January 10, 2022 Category: Biochemistry Authors: Dilek Karatas Veysi Oz Ismail Yener Mehmet Akdeniz Figen Erek Is ıl Aydin Serkan Yigitkan Mustafa Abdullah Y ılmaz Abdulselam Ertas Source Type: research

Bioassay Directed Fractionation of Petroleum Ether Extract of Aerial Parts of Ceriops tagal: Isolation of Lupeol as the Nematicidal Agent against Cyst Nematode Heterodera zeae
Chem Biodivers. 2022 Jan 10. doi: 10.1002/cbdv.202100759. Online ahead of print.ABSTRACTPlant parasitic cyst nematode Heterodera zeae is a pest, causing substantial economic losses in agriculture. Organic pesticides, based on plant products have emerged as eco-benign nematicidal agents. Ceriops tagal is a well-known marine medicinal plant which has not been evaluated against any nematode. Petroleum ether extract of the aerial parts of the plant (CTP), exhibited promising activity against infective stage larvae of H. zeae . On subjecting to classical solvent-solvent separation, it afforded petroleum ether soluble (CTP-S), m...
Source: Chemistry and Biodiversity - January 10, 2022 Category: Biochemistry Authors: Ateeq Ahmad Shaheen Faizi Pirzada J A Siddiqui Shahina Fayyaz Kehkashan Khan Erum Y Iqbal Munawwer Rasheed Wajeeha Muzafar Source Type: research

Structure analysis and anti-inflammatory effect of a polysaccharide from Hippocampus mohnikei
Chem Biodivers. 2022 Jan 9. doi: 10.1002/cbdv.202100739. Online ahead of print.ABSTRACTThe purpose of this study was to analyze the structure of a polysaccharide (HMP-1) from Hippocampus mohnikei, and to explore its anti-inflammatory effect. HMP-1 was obtained from Hippocampus mohnikei by ethanol sedimentation and secondary column chromatography purification. Its structural characteristics were analyzed by gel permeation chromatography (GPC), fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and scanning electron micrograph (SEM). Results showed its molecular weight (Mw) was 729...
Source: Chemistry and Biodiversity - January 10, 2022 Category: Biochemistry Authors: Mingxiao Cui Yu Wang Kehai Liu Source Type: research

Saringosterol acetate isolated from Sargassum fusiformis induces mitochondrial-mediated apoptosis in MCF-7 breast cancer cells
In this study, SA was investigated for its anticancer effect on MCF-7 breast cancer cells. SA attenuated the survival rate of MCF-7 cells with an IC50 value of 63.16 ± 3.6 ug/mL. Staining with Hoechst 33342 demonstrated that SA treatment mediated apoptotic body generation. SA significantly downregulated Bcl-xL and upregulated Bax, and cleaved PARP, and cleaved caspase 3 in a dose-dependent manner. Thus, these results suggest that SA induced mitochondria-mediated apoptosis in MCF-7 cells, making it a plausible candidate for drug development against breast cancer.PMID:34997687 | DOI:10.1002/cbdv.202100848 (Source: Che...
Source: Chemistry and Biodiversity - January 8, 2022 Category: Biochemistry Authors: Xue Li DongYue Zhou FangTong Li YunFei Jiang Yulin Dai YouJin Jeon Source Type: research

A Comparative DFT Study on the Antioxidant Activity of some Novel 3-hydroxypyridine-4-one Derivatives
Chem Biodivers. 2022 Jan 8. doi: 10.1002/cbdv.202100703. Online ahead of print.ABSTRACTThe current study on the antioxidant activity of Kojic acid and 3-hydroxypyridine-4-one derivatives was performed by implementation of density functional theory calculations with the B3LYP hybrid functional and the 6-311++ G** basis set in Polarizable Continuum Model. Compounds under evaluation were previously synthesized by our research group. The DPPH scavenging effect and IC 50 values of them in mM concentrations were evaluated. Subsequently, various electronic and energetic descriptors such as HOMO and LUMO energy gaps, bonding disso...
Source: Chemistry and Biodiversity - January 8, 2022 Category: Biochemistry Authors: Mehrdad M Dehkordi Mohammad H Asgarshamsi Afshin Fassihi Krzysztof Kazimierz Zborowski Source Type: research

Phenolics, flavonoids content and antioxidant activities of Tuber indicum at different maturity stages
This study provided important data for understanding the relationship between maturity stages and truffle formation and evaluating the quality of Chinese black truffle at different maturity.PMID:34997953 | DOI:10.1002/cbdv.202100830 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - January 8, 2022 Category: Biochemistry Authors: Yang Li Hanqiao Liang Dongyu Zhou Yongmei Xing Juan Chen Source Type: research

Saringosterol acetate isolated from Sargassum fusiformis induces mitochondrial-mediated apoptosis in MCF-7 breast cancer cells
In this study, SA was investigated for its anticancer effect on MCF-7 breast cancer cells. SA attenuated the survival rate of MCF-7 cells with an IC50 value of 63.16 ± 3.6 ug/mL. Staining with Hoechst 33342 demonstrated that SA treatment mediated apoptotic body generation. SA significantly downregulated Bcl-xL and upregulated Bax, and cleaved PARP, and cleaved caspase 3 in a dose-dependent manner. Thus, these results suggest that SA induced mitochondria-mediated apoptosis in MCF-7 cells, making it a plausible candidate for drug development against breast cancer.PMID:34997687 | DOI:10.1002/cbdv.202100848 (Source: Che...
Source: Chemistry and Biodiversity - January 8, 2022 Category: Biochemistry Authors: Xue Li DongYue Zhou FangTong Li YunFei Jiang Yulin Dai YouJin Jeon Source Type: research

A Comparative DFT Study on the Antioxidant Activity of some Novel 3-hydroxypyridine-4-one Derivatives
Chem Biodivers. 2022 Jan 8. doi: 10.1002/cbdv.202100703. Online ahead of print.ABSTRACTThe current study on the antioxidant activity of Kojic acid and 3-hydroxypyridine-4-one derivatives was performed by implementation of density functional theory calculations with the B3LYP hybrid functional and the 6-311++ G** basis set in Polarizable Continuum Model. Compounds under evaluation were previously synthesized by our research group. The DPPH scavenging effect and IC 50 values of them in mM concentrations were evaluated. Subsequently, various electronic and energetic descriptors such as HOMO and LUMO energy gaps, bonding disso...
Source: Chemistry and Biodiversity - January 8, 2022 Category: Biochemistry Authors: Mehrdad M Dehkordi Mohammad H Asgarshamsi Afshin Fassihi Krzysztof Kazimierz Zborowski Source Type: research

Phenolics, flavonoids content and antioxidant activities of Tuber indicum at different maturity stages
This study provided important data for understanding the relationship between maturity stages and truffle formation and evaluating the quality of Chinese black truffle at different maturity.PMID:34997953 | DOI:10.1002/cbdv.202100830 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - January 8, 2022 Category: Biochemistry Authors: Yang Li Hanqiao Liang Dongyu Zhou Yongmei Xing Juan Chen Source Type: research

Leaf and Flower Extracts of Six Michelia L.: Polyphenolic Composition, Antioxidant, Antibacterial Activities and in  Vitro Inhibition of α-Amylase and α-Glucosidase
This study explored the biological activities of six Michelia species, and provided reference for variety selection with the aim of designing novel phyto-pharmaceuticals.PMID:34994077 | DOI:10.1002/cbdv.202100894 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - January 7, 2022 Category: Biochemistry Authors: Tianzhu Liao Jiwu Cao Zhenyu Yang Jing Cheng Jun Lu Source Type: research

Fabrication and characterization of thymol-loaded chitosan nanogels: improved antibacterial and anti-biofilm activities with negligible cytotoxicity
Chem Biodivers. 2022 Jan 6. doi: 10.1002/cbdv.202100426. Online ahead of print.ABSTRACTThymol is a monoterpene phenolic derivative extracted from the Thymus vulgaris which has antimicrobial effects. In the present study, thymol-loaded chitosan nanogels were prepared and their physicochemical properties were characterized. The encapsulation efficiency of thymol into chitosan and its stability were determined. The in-vitro antimicrobial and anti-biofilm activities of thymol-loaded chitosan nanogel (Ty-CsNG), free thymol (Ty), and free chitosan nanogel (CsNG) were evaluated against both Gram-negative and Gram-positive multidr...
Source: Chemistry and Biodiversity - January 6, 2022 Category: Biochemistry Authors: Tohid Piri Gharaghie Sheida Beiranvand Anali Riahi Farzad Badmasti Neda Jegargoshe Shirin Amir Mirzaie Yalda Elahianfar Somayeh Ghahari Sajjad Ghahari Kamal Pasban Shadi Hajrasoliha Source Type: research

Flavonoid-rich fraction from Croton blanchetianus (Euphorbiaceae) leaves exerts peripheral and central analgesic effects by acting via the opioid and cholinergic systems
This study provides new scientific evidence on the pharmacological properties of C. blanchetianus leaves and their potential for the development of phytomedicines with analgesic properties.PMID:34990049 | DOI:10.1002/cbdv.202100853 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - January 6, 2022 Category: Biochemistry Authors: Alisson Oliveira Ramona Widmer Matheus Nascimento Wendeo Costa Patricia Paiva Thiago Henrique Napole ão Source Type: research

An Allosteric Inhibitory Potential of Triterpenes from Combretum racemosum on the Structural and Functional Dynamics of Plasmodium falciparum Lactate Dehydrogenase Binding Landscape
Chem Biodivers. 2022 Jan 4:e202100646. doi: 10.1002/cbdv.202100646. Online ahead of print.ABSTRACTMultidrug resistance is a significant drawback in malaria treatment, and mutations in the active sites of the many critical antimalarial drug targets have remained challenging. Therefore, this has necessitated the global search for new drugs with new mechanisms of action. Plasmodium falciparum lactate dehydrogenase (pfLHD), a glycolytic enzyme, has emerged as a potential target for developing new drugs due to the parasite reliance on glycolysis for energy. Strong substrate-binding is required in pfLDH enzymatic catalysis; howe...
Source: Chemistry and Biodiversity - January 4, 2022 Category: Biochemistry Authors: Wande M Oluyemi Babatunde B Samuel Adeniyi T Adewumi Yemi A Adekunle Mahmoud E S Soliman Liselotte Krenn Source Type: research

Antifouling Diterpenoids from the Sponge Dendrilla antarctica
Chem Biodivers. 2021 Dec 29:e202100618. doi: 10.1002/cbdv.202100618. Online ahead of print.ABSTRACTTwo nor-diterpenes, 9,11-dihydrogracilin A (1) and the previously unreported 9,11-dihydrogracillinone A (2), were isolated from the sponge Dendrilla antarctica. The sponge was collected by trawling at a depth of 49 m, from the research vessel Puerto Deseado, near the coast of Tierra del Fuego, farther north than the reported habitat for this species. Since these compounds were particularly abundant and the sponge was free from epibionts, both 1 and 2 were included in soluble-matrix paints and tested for antifouling activity i...
Source: Chemistry and Biodiversity - December 29, 2021 Category: Biochemistry Authors: Iv án M Prieto Anal ía Paola Miriam P érez M ónica García Guillermo Blustein Laura Schejter Jorge A Palermo Source Type: research

Quercus salicina Blume: Research progress in chemistry and pharmacodynamics (1959-2021)
Chem Biodivers. 2021 Dec 28. doi: 10.1002/cbdv.202100777. Online ahead of print.ABSTRACTThe crude extracts of different parts (leaves and shoots) of Quercus salicina Blume (QS) have shown considerable effect in urolithiasis. QS has been widely used in clinical practice and has attracted great research interest The relevant published literature, however, reveals only partial education of its chemical components and bio-active mechanisms, and only two review papers have summarized the QS research progress. In this review, a comprehensive and systematic review of chemistry and pharmacodynamics of QS was carried out using the ...
Source: Chemistry and Biodiversity - December 29, 2021 Category: Biochemistry Authors: Wang Guang Yue Shuanghui Yin Yuling Ding Zhe Lin Yong Li Source Type: research

Microbial Degradation of 2-Methylisoborneol in Forest Soil
Chem Biodivers. 2021 Dec 29:e202100734. doi: 10.1002/cbdv.202100734. Online ahead of print.ABSTRACTMicroorganisms use a complex array of chemical compounds to interact with their surroundings. They produce and process different molecules in response to changes in the environment or in their metabolism. One of the most well-known volatile organic compounds produced by microorganisms is the C11-terpenoid 2-methylisoborneol (2-MIB), which has received attention because of the off-flavor it confers to fresh and reservoir water as well as to cultured fish. Cleaning water supplies of the off-flavor 2-MIB has been of interest for...
Source: Chemistry and Biodiversity - December 29, 2021 Category: Biochemistry Authors: Laura Drummond Christian von Wallbrunn Markus Buchhaupt Source Type: research

Phenolic composition of inflorescences of Carduus nutans L
Chem Biodivers. 2021 Dec 29. doi: 10.1002/cbdv.202100827. Online ahead of print.ABSTRACTCarduus nutans L. (Compositae) has been extensively used for medicinal purposes. As other representatives of the genus it is implemented in the treatment of liver disorders and used as diuretic and digestive agent. Previous studies have determined the predominant classes of secondary metabolites in Carduus species. Among the major representatives of their extracts flavonoids, phenolic acids, coumarins, sterols and terpenes were identified. The antiradical capacity of three extracts assessed in the DPPH test revealed the highest radical ...
Source: Chemistry and Biodiversity - December 29, 2021 Category: Biochemistry Authors: Malgorzata Kozyra Malgorzata Kozyra Wirginia Kuku ła-Koch Micha ł Szymański Source Type: research

Antifouling Diterpenoids from the Sponge Dendrilla antarctica
Chem Biodivers. 2021 Dec 29:e202100618. doi: 10.1002/cbdv.202100618. Online ahead of print.ABSTRACTTwo nor-diterpenes, 9,11-dihydrogracilin A (1) and the previously unreported 9,11-dihydrogracillinone A (2), were isolated from the sponge Dendrilla antarctica. The sponge was collected by trawling at a depth of 49 m, from the research vessel Puerto Deseado, near the coast of Tierra del Fuego, farther north than the reported habitat for this species. Since these compounds were particularly abundant and the sponge was free from epibionts, both 1 and 2 were included in soluble-matrix paints and tested for antifouling activity i...
Source: Chemistry and Biodiversity - December 29, 2021 Category: Biochemistry Authors: Iv án M Prieto Anal ía Paola Miriam P érez M ónica García Guillermo Blustein Laura Schejter Jorge A Palermo Source Type: research

Quercus salicina Blume: Research progress in chemistry and pharmacodynamics (1959-2021)
Chem Biodivers. 2021 Dec 28. doi: 10.1002/cbdv.202100777. Online ahead of print.ABSTRACTThe crude extracts of different parts (leaves and shoots) of Quercus salicina Blume (QS) have shown considerable effect in urolithiasis. QS has been widely used in clinical practice and has attracted great research interest The relevant published literature, however, reveals only partial education of its chemical components and bio-active mechanisms, and only two review papers have summarized the QS research progress. In this review, a comprehensive and systematic review of chemistry and pharmacodynamics of QS was carried out using the ...
Source: Chemistry and Biodiversity - December 29, 2021 Category: Biochemistry Authors: Wang Guang Yue Shuanghui Yin Yuling Ding Zhe Lin Yong Li Source Type: research

Microbial Degradation of 2-Methylisoborneol in Forest Soil
Chem Biodivers. 2021 Dec 29:e202100734. doi: 10.1002/cbdv.202100734. Online ahead of print.ABSTRACTMicroorganisms use a complex array of chemical compounds to interact with their surroundings. They produce and process different molecules in response to changes in the environment or in their metabolism. One of the most well-known volatile organic compounds produced by microorganisms is the C11-terpenoid 2-methylisoborneol (2-MIB), which has received attention because of the off-flavor it confers to fresh and reservoir water as well as to cultured fish. Cleaning water supplies of the off-flavor 2-MIB has been of interest for...
Source: Chemistry and Biodiversity - December 29, 2021 Category: Biochemistry Authors: Laura Drummond Christian von Wallbrunn Markus Buchhaupt Source Type: research

Phenolic composition of inflorescences of Carduus nutans L
Chem Biodivers. 2021 Dec 29. doi: 10.1002/cbdv.202100827. Online ahead of print.ABSTRACTCarduus nutans L. (Compositae) has been extensively used for medicinal purposes. As other representatives of the genus it is implemented in the treatment of liver disorders and used as diuretic and digestive agent. Previous studies have determined the predominant classes of secondary metabolites in Carduus species. Among the major representatives of their extracts flavonoids, phenolic acids, coumarins, sterols and terpenes were identified. The antiradical capacity of three extracts assessed in the DPPH test revealed the highest radical ...
Source: Chemistry and Biodiversity - December 29, 2021 Category: Biochemistry Authors: Malgorzata Kozyra Malgorzata Kozyra Wirginia Kuku ła-Koch Micha ł Szymański Source Type: research

Antifouling Diterpenoids from the Sponge Dendrilla antarctica
Chem Biodivers. 2021 Dec 29:e202100618. doi: 10.1002/cbdv.202100618. Online ahead of print.ABSTRACTTwo nor-diterpenes, 9,11-dihydrogracilin A (1) and the previously unreported 9,11-dihydrogracillinone A (2), were isolated from the sponge Dendrilla antarctica. The sponge was collected by trawling at a depth of 49 m, from the research vessel Puerto Deseado, near the coast of Tierra del Fuego, farther north than the reported habitat for this species. Since these compounds were particularly abundant and the sponge was free from epibionts, both 1 and 2 were included in soluble-matrix paints and tested for antifouling activity i...
Source: Chemistry and Biodiversity - December 29, 2021 Category: Biochemistry Authors: Iv án M Prieto Anal ía Paola Miriam P érez M ónica García Guillermo Blustein Laura Schejter Jorge A Palermo Source Type: research

Quercus salicina Blume: Research progress in chemistry and pharmacodynamics (1959-2021)
Chem Biodivers. 2021 Dec 28. doi: 10.1002/cbdv.202100777. Online ahead of print.ABSTRACTThe crude extracts of different parts (leaves and shoots) of Quercus salicina Blume (QS) have shown considerable effect in urolithiasis. QS has been widely used in clinical practice and has attracted great research interest The relevant published literature, however, reveals only partial education of its chemical components and bio-active mechanisms, and only two review papers have summarized the QS research progress. In this review, a comprehensive and systematic review of chemistry and pharmacodynamics of QS was carried out using the ...
Source: Chemistry and Biodiversity - December 29, 2021 Category: Biochemistry Authors: Wang Guang Yue Shuanghui Yin Yuling Ding Zhe Lin Yong Li Source Type: research

Microbial Degradation of 2-Methylisoborneol in Forest Soil
Chem Biodivers. 2021 Dec 29:e202100734. doi: 10.1002/cbdv.202100734. Online ahead of print.ABSTRACTMicroorganisms use a complex array of chemical compounds to interact with their surroundings. They produce and process different molecules in response to changes in the environment or in their metabolism. One of the most well-known volatile organic compounds produced by microorganisms is the C11-terpenoid 2-methylisoborneol (2-MIB), which has received attention because of the off-flavor it confers to fresh and reservoir water as well as to cultured fish. Cleaning water supplies of the off-flavor 2-MIB has been of interest for...
Source: Chemistry and Biodiversity - December 29, 2021 Category: Biochemistry Authors: Laura Drummond Christian von Wallbrunn Markus Buchhaupt Source Type: research

Phenolic composition of inflorescences of Carduus nutans L
Chem Biodivers. 2021 Dec 29. doi: 10.1002/cbdv.202100827. Online ahead of print.ABSTRACTCarduus nutans L. (Compositae) has been extensively used for medicinal purposes. As other representatives of the genus it is implemented in the treatment of liver disorders and used as diuretic and digestive agent. Previous studies have determined the predominant classes of secondary metabolites in Carduus species. Among the major representatives of their extracts flavonoids, phenolic acids, coumarins, sterols and terpenes were identified. The antiradical capacity of three extracts assessed in the DPPH test revealed the highest radical ...
Source: Chemistry and Biodiversity - December 29, 2021 Category: Biochemistry Authors: Malgorzata Kozyra Malgorzata Kozyra Wirginia Kuku ła-Koch Micha ł Szymański Source Type: research

Antifouling Diterpenoids from the Sponge Dendrilla antarctica
Chem Biodivers. 2021 Dec 29:e202100618. doi: 10.1002/cbdv.202100618. Online ahead of print.ABSTRACTTwo nor-diterpenes, 9,11-dihydrogracilin A (1) and the previously unreported 9,11-dihydrogracillinone A (2), were isolated from the sponge Dendrilla antarctica. The sponge was collected by trawling at a depth of 49 m, from the research vessel Puerto Deseado, near the coast of Tierra del Fuego, farther north than the reported habitat for this species. Since these compounds were particularly abundant and the sponge was free from epibionts, both 1 and 2 were included in soluble-matrix paints and tested for antifouling activity i...
Source: Chemistry and Biodiversity - December 29, 2021 Category: Biochemistry Authors: Iv án M Prieto Anal ía Paola Miriam P érez M ónica García Guillermo Blustein Laura Schejter Jorge A Palermo Source Type: research

Quercus salicina Blume: Research progress in chemistry and pharmacodynamics (1959-2021)
Chem Biodivers. 2021 Dec 28. doi: 10.1002/cbdv.202100777. Online ahead of print.ABSTRACTThe crude extracts of different parts (leaves and shoots) of Quercus salicina Blume (QS) have shown considerable effect in urolithiasis. QS has been widely used in clinical practice and has attracted great research interest The relevant published literature, however, reveals only partial education of its chemical components and bio-active mechanisms, and only two review papers have summarized the QS research progress. In this review, a comprehensive and systematic review of chemistry and pharmacodynamics of QS was carried out using the ...
Source: Chemistry and Biodiversity - December 29, 2021 Category: Biochemistry Authors: Wang Guang Yue Shuanghui Yin Yuling Ding Zhe Lin Yong Li Source Type: research

Microbial Degradation of 2-Methylisoborneol in Forest Soil
Chem Biodivers. 2021 Dec 29:e202100734. doi: 10.1002/cbdv.202100734. Online ahead of print.ABSTRACTMicroorganisms use a complex array of chemical compounds to interact with their surroundings. They produce and process different molecules in response to changes in the environment or in their metabolism. One of the most well-known volatile organic compounds produced by microorganisms is the C11-terpenoid 2-methylisoborneol (2-MIB), which has received attention because of the off-flavor it confers to fresh and reservoir water as well as to cultured fish. Cleaning water supplies of the off-flavor 2-MIB has been of interest for...
Source: Chemistry and Biodiversity - December 29, 2021 Category: Biochemistry Authors: Laura Drummond Christian von Wallbrunn Markus Buchhaupt Source Type: research

Phenolic composition of inflorescences of Carduus nutans L
Chem Biodivers. 2021 Dec 29. doi: 10.1002/cbdv.202100827. Online ahead of print.ABSTRACTCarduus nutans L. (Compositae) has been extensively used for medicinal purposes. As other representatives of the genus it is implemented in the treatment of liver disorders and used as diuretic and digestive agent. Previous studies have determined the predominant classes of secondary metabolites in Carduus species. Among the major representatives of their extracts flavonoids, phenolic acids, coumarins, sterols and terpenes were identified. The antiradical capacity of three extracts assessed in the DPPH test revealed the highest radical ...
Source: Chemistry and Biodiversity - December 29, 2021 Category: Biochemistry Authors: Malgorzata Kozyra Malgorzata Kozyra Wirginia Kuku ła-Koch Micha ł Szymański Source Type: research

Antifouling Diterpenoids from the Sponge Dendrilla antarctica
Chem Biodivers. 2021 Dec 29:e202100618. doi: 10.1002/cbdv.202100618. Online ahead of print.ABSTRACTTwo nor-diterpenes, 9,11-dihydrogracilin A (1) and the previously unreported 9,11-dihydrogracillinone A (2), were isolated from the sponge Dendrilla antarctica. The sponge was collected by trawling at a depth of 49 m, from the research vessel Puerto Deseado, near the coast of Tierra del Fuego, farther north than the reported habitat for this species. Since these compounds were particularly abundant and the sponge was free from epibionts, both 1 and 2 were included in soluble-matrix paints and tested for antifouling activity i...
Source: Chemistry and Biodiversity - December 29, 2021 Category: Biochemistry Authors: Iv án M Prieto Anal ía Paola Miriam P érez M ónica García Guillermo Blustein Laura Schejter Jorge A Palermo Source Type: research

Quercus salicina Blume: Research progress in chemistry and pharmacodynamics (1959-2021)
Chem Biodivers. 2021 Dec 28. doi: 10.1002/cbdv.202100777. Online ahead of print.ABSTRACTThe crude extracts of different parts (leaves and shoots) of Quercus salicina Blume (QS) have shown considerable effect in urolithiasis. QS has been widely used in clinical practice and has attracted great research interest The relevant published literature, however, reveals only partial education of its chemical components and bio-active mechanisms, and only two review papers have summarized the QS research progress. In this review, a comprehensive and systematic review of chemistry and pharmacodynamics of QS was carried out using the ...
Source: Chemistry and Biodiversity - December 29, 2021 Category: Biochemistry Authors: Wang Guang Yue Shuanghui Yin Yuling Ding Zhe Lin Yong Li Source Type: research

Microbial Degradation of 2-Methylisoborneol in Forest Soil
Chem Biodivers. 2021 Dec 29:e202100734. doi: 10.1002/cbdv.202100734. Online ahead of print.ABSTRACTMicroorganisms use a complex array of chemical compounds to interact with their surroundings. They produce and process different molecules in response to changes in the environment or in their metabolism. One of the most well-known volatile organic compounds produced by microorganisms is the C11-terpenoid 2-methylisoborneol (2-MIB), which has received attention because of the off-flavor it confers to fresh and reservoir water as well as to cultured fish. Cleaning water supplies of the off-flavor 2-MIB has been of interest for...
Source: Chemistry and Biodiversity - December 29, 2021 Category: Biochemistry Authors: Laura Drummond Christian von Wallbrunn Markus Buchhaupt Source Type: research

Phenolic composition of inflorescences of Carduus nutans L
Chem Biodivers. 2021 Dec 29. doi: 10.1002/cbdv.202100827. Online ahead of print.ABSTRACTCarduus nutans L. (Compositae) has been extensively used for medicinal purposes. As other representatives of the genus it is implemented in the treatment of liver disorders and used as diuretic and digestive agent. Previous studies have determined the predominant classes of secondary metabolites in Carduus species. Among the major representatives of their extracts flavonoids, phenolic acids, coumarins, sterols and terpenes were identified. The antiradical capacity of three extracts assessed in the DPPH test revealed the highest radical ...
Source: Chemistry and Biodiversity - December 29, 2021 Category: Biochemistry Authors: Malgorzata Kozyra Malgorzata Kozyra Wirginia Kuku ła-Koch Micha ł Szymański Source Type: research

Dose-dependent effect of Wedelia trilobata essential oil (EO) on lettuce (Lactuca sativa L.) with multivariate analysis
In this study, a gas chromatography-mass spectrometry (GC-MS) based metabolomics approach was used to determine the metabolite changes in lettuce (Lactuca sativa L.) shoot and root after exposure to different concentrations of W. trilobata EO. Multivariate analyses of principal component analysis (PCA) and orthogonal partial least-discriminant analysis (OPLS-DA) corroborated that shoot and root of lettuce responded differently to W. trilobata EO. In EO-exposed shoot samples, an increase in the levels of malic acid, glutamine, serine, lactose and α-glucopyranose affected important metabolism pathways such as glycolysi...
Source: Chemistry and Biodiversity - December 28, 2021 Category: Biochemistry Authors: Kamalrul Azlan Azizan Arief Izzairy Zamani Nor Azlan Nor Muhammad Khairunisa Khairudin Nornasuha Yusoff Mohamad Firdaus Nawawi Source Type: research

Potential mechanisms of methylglyoxal-induced human embryonic kidney cells damage: Regulation of oxidative stress, DNA damage, and apoptosis
Chem Biodivers. 2021 Dec 27. doi: 10.1002/cbdv.202100829. Online ahead of print.ABSTRACTMethylglyoxal (MGO) is a reactive carbonyl species that can cause cellular damage and is closely related to kidney disease, especially diabetic nephropathy. The toxic effect of MGO (0.5, 1, and 2 mM) on human embryonic kidney (HEK293) cells and its underlying mechanism were explored in this study. Cell viability, apoptosis and the signaling pathways were measured with MTT, fluorescent staining and western blot experiments, the results showed that MGO could induce oxidative stress and cell inflammation, the level of reactive oxygen speci...
Source: Chemistry and Biodiversity - December 28, 2021 Category: Biochemistry Authors: Dan Liu Ye Cheng Zhipeng Tang Junliang Chen Ying Xia Chengbin Xu Xiangyu Cao Source Type: research

Dose-dependent effect of Wedelia trilobata essential oil (EO) on lettuce (Lactuca sativa L.) with multivariate analysis
In this study, a gas chromatography-mass spectrometry (GC-MS) based metabolomics approach was used to determine the metabolite changes in lettuce (Lactuca sativa L.) shoot and root after exposure to different concentrations of W. trilobata EO. Multivariate analyses of principal component analysis (PCA) and orthogonal partial least-discriminant analysis (OPLS-DA) corroborated that shoot and root of lettuce responded differently to W. trilobata EO. In EO-exposed shoot samples, an increase in the levels of malic acid, glutamine, serine, lactose and α-glucopyranose affected important metabolism pathways such as glycolysi...
Source: Chemistry and Biodiversity - December 28, 2021 Category: Biochemistry Authors: Kamalrul Azlan Azizan Arief Izzairy Zamani Nor Azlan Nor Muhammad Khairunisa Khairudin Nornasuha Yusoff Mohamad Firdaus Nawawi Source Type: research

Potential mechanisms of methylglyoxal-induced human embryonic kidney cells damage: Regulation of oxidative stress, DNA damage, and apoptosis
Chem Biodivers. 2021 Dec 27. doi: 10.1002/cbdv.202100829. Online ahead of print.ABSTRACTMethylglyoxal (MGO) is a reactive carbonyl species that can cause cellular damage and is closely related to kidney disease, especially diabetic nephropathy. The toxic effect of MGO (0.5, 1, and 2 mM) on human embryonic kidney (HEK293) cells and its underlying mechanism were explored in this study. Cell viability, apoptosis and the signaling pathways were measured with MTT, fluorescent staining and western blot experiments, the results showed that MGO could induce oxidative stress and cell inflammation, the level of reactive oxygen speci...
Source: Chemistry and Biodiversity - December 28, 2021 Category: Biochemistry Authors: Dan Liu Ye Cheng Zhipeng Tang Junliang Chen Ying Xia Chengbin Xu Xiangyu Cao Source Type: research