Mini Reviews in Medicinal Chemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Schiff Bases: A Captivating Scaffold with Potential Anticonvulsant Activity
Mini Rev Med Chem. 2024 Apr 16. doi: 10.2174/0113895575302197240408121537. Online ahead of print.ABSTRACTOne of the most important organic compounds, also known as a Schiff base, imine, or azomethine, has been associated with several biological processes. The group is a component of both natural or synthetic chemicals and functions as both a precursor and an intermediary in the synthesis of therapeutically active substances. The review highlights the various non-metal Schiff bases' structure-activity relationship (SAR) studies, general model, docking, and design approach for anticonvulsant actions. Schiff bases serve as li...
Source: Mini Reviews in Medicinal Chemistry - April 17, 2024 Category: Chemistry Authors: Rakesh Sahu Kamal Shah Source Type: research

The Pivotal Function of SLC16A1 and SLC16A1-AS1 in Cancer Progress: Molecular Pathogenesis and Prognosis
Mini Rev Med Chem. 2024 Apr 8. doi: 10.2174/0113895575284780240327103039. Online ahead of print.ABSTRACTMore than 300 membranes make up the SLC family of transporters, utilizing an ion gradient or electrochemical potential difference to move their substrates across biological membranes. The SLC16 gene family contains fourteen members. Proton-linked transportation of monocarboxylates can be promoted by the transporters MCT1, which the SLC16A1 gene family encodes. Glycolysis is constitutively up-regulated in cancer cells, and the amount of lactate produced as a result is correlated with prognosis. Further speaking, SLC16A1 p...
Source: Mini Reviews in Medicinal Chemistry - April 15, 2024 Category: Chemistry Authors: Yunxi Zhou Fangshun Tan Zhuowei Wang Gang Zhou Chengfu Yuan Source Type: research

The Indispensable Roles of GMDS and GMDS-AS1 in the Advancement of Cancer: Fucosylation, Signal Pathway and Molecular Pathogenesis
Mini Rev Med Chem. 2024 Apr 5. doi: 10.2174/0113895575285276240324080234. Online ahead of print.ABSTRACTFucosylation is facilitated by converting GDP-mannose to GDP-4-keto-6-deoxymannose, which GDP-mannose 4,6-dehydratase, a crucial enzyme in the route, carries out. One of the most prevalent glycosylation alterations linked to cancer has reportedly been identified as fucosylation. There is mounting evidence that GMDS is intimately linked to the onset and spread of cancer. Furthermore, the significance of long-chain non-coding RNAs in the development and metastasis of cancer is becoming more well-recognized, and the regulat...
Source: Mini Reviews in Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Ziyan Zhang Zhuowei Wang Hong Fan Jiayi Li Jiaqi Ding Gang Zhou Chengfu Yuan Source Type: research

Structural Perspectives in the Development of Novel EGFR Inhibitors for the Treatment of NSCLC
Mini Rev Med Chem. 2024 Apr 4. doi: 10.2174/0113895575296174240323172754. Online ahead of print.ABSTRACTNon-small cell Lung cancer (NSCLC) is the most common type of lung cancer, which is caused by high consumption of tobacco and smoking. It is an epithelial lung cancer that affects about 2.2 million people across the globe, according to International Agency for Research on Cancer (IARC). Non-small cell lung cancer is a malignant tumor caused by EGFR mutation that occurs in the in-frame deletion of exon 19 and L858R point mutation in exon 21. Presently, clinically available inhibitors of EGFR (including erlotinib, lapatini...
Source: Mini Reviews in Medicinal Chemistry - April 8, 2024 Category: Chemistry Authors: Rahul Makhija Anushka Sharma Rahul Dubey Vivek Asati Source Type: research

Diabetes Pharmacotherapy and its effects on the Skeletal Muscle Energy Metabolism
Mini Rev Med Chem. 2024 Feb 16. doi: 10.2174/0113895575299439240216081711. Online ahead of print.ABSTRACTThe disorders of skeletal muscle metabolism in patients with Type 2 diabetes mellitus (T2DM), such as mitochondrial defection and glucose transporters (GLUTs) translocation dysfunctions, are not uncommon. Therefore, when anti-diabetic drugs were used in various chronic diseases associated with hyperglycemia, the impact on skeletal muscle should not be ignored. However, current studies mainly focus on muscle mass rather than metabolism or functions. Anti-diabetic drugs might have a harmful or beneficial impact on skeleta...
Source: Mini Reviews in Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Baowen Yu Dong Wang Junming Zhou Rong Huang Tingting Cai Yonghui Hu Yunting Zhou Jianhua Ma Source Type: research