Unveiling microbial degradation of triclosan: Degradation mechanism, pathways, and catalyzing clean energy
Chemosphere. 2024 Apr 16;357:142053. doi: 10.1016/j.chemosphere.2024.142053. Online ahead of print.ABSTRACTEmerging organic contaminants present in the environment can be biodegraded in anodic biofilms of microbial fuel cells (MFCs). However, there is a notable gap existing in deducing the degradation mechanism, intermediate products, and the microbial communities involved in degradation of broad-spectrum antibiotic such as triclosan (TCS). Herein, the possible degradation of TCS is explored using TCS acclimatized biofilms in MFCs. 95% of 5 mgL-1 TCS are been biodegraded within 84 h with a chemical oxygen demand (COD) redu...
Source: Chemosphere - April 18, 2024 Category: Chemistry Authors: Gopa Nandikes Pankaj Pathak Lakhveer Singh Source Type: research
Enantioselective Bioaccumulation and Toxicological Effects of Chiral Neonicotinoid Sulfoxaflor in Rats
In this study, toxicokinetics, bioaccumulation, tissue distribution and enantiomeric profiles of sulfoxaflor in rats were investigated through single oral exposure and 28-days continuous exposure experiment. Sulfoxaflor mainly accumulated in liver and kidney, and the (-)-2R,3R-sufloxaflor and (-)-2S,3R-sufloxaflor had higher enrichment than their enantiomers in rats. The toxicological effects were evaluated after 28-days exposure. Slight inflammation in liver and kidney were observed by histopathology. Sphingolipid, amino acid, and vitamin B6 metabolism pathways were significantly disturbed in metabonomics analysis. These ...
Source: Chemosphere - April 18, 2024 Category: Chemistry Authors: Yaofeng Fang Shengchen Lv Shouchun Xiao Haonan Hou Jianing Yao Yue Cao Bingying He Xueke Liu Peng Wang Donghui Liu Zhiqiang Zhou Source Type: research
An α-helical peptide-based plasmonic biosensor for highly specific detection of α-synuclein toxic oligomers
We describe the integration of the peptide in a lab-on-a-chip plasmonic platform suitable for point-of-care measurements of αS toxic oligomers in CSF samples in real-time and at an affordable cost, providing an innovative biosensor for PD early diagnosis in the clinic.PMID:38637056 | DOI:10.1016/j.aca.2024.342559 (Source: Analytica Chimica Acta)
Source: Analytica Chimica Acta - April 18, 2024 Category: Chemistry Authors: Juliana F átima Giarola Jaime Santos M-Carmen Estevez Salvador Ventura Irantzu Pallar ès Laura M Lechuga Source Type: research
Histidine tag modified magnetic beads for analysis of arsenic binding proteins
Anal Chim Acta. 2024 May 22;1304:342554. doi: 10.1016/j.aca.2024.342554. Epub 2024 Mar 29.ABSTRACTBACKGROUND: Many proteins with thiol groups can bind with trivalent arsenic which are termed as arsenic binding proteins, thus change their physiological functions. Therefore, it is vital to analyze the arsenic binding proteins in cells. The Pull-Down strategy based on biotinylated phenylarsenic acid (Bio-PAO(III)) probes is an effective way for analysis of arsenic binding proteins. In this strategy, streptavidin magnetic beads (SA-MBs) was applied to capture the arsenic binding proteins conjugating with Bio-PAO(III) probe. Ho...
Source: Analytica Chimica Acta - April 18, 2024 Category: Chemistry Authors: Kai Nan Man He Beibei Chen Bin Hu Source Type: research
Unveiling microbial degradation of triclosan: Degradation mechanism, pathways, and catalyzing clean energy
Chemosphere. 2024 Apr 16;357:142053. doi: 10.1016/j.chemosphere.2024.142053. Online ahead of print.ABSTRACTEmerging organic contaminants present in the environment can be biodegraded in anodic biofilms of microbial fuel cells (MFCs). However, there is a notable gap existing in deducing the degradation mechanism, intermediate products, and the microbial communities involved in degradation of broad-spectrum antibiotic such as triclosan (TCS). Herein, the possible degradation of TCS is explored using TCS acclimatized biofilms in MFCs. 95% of 5 mgL-1 TCS are been biodegraded within 84 h with a chemical oxygen demand (COD) redu...
Source: Chemosphere - April 18, 2024 Category: Chemistry Authors: Gopa Nandikes Pankaj Pathak Lakhveer Singh Source Type: research
Enantioselective Bioaccumulation and Toxicological Effects of Chiral Neonicotinoid Sulfoxaflor in Rats
In this study, toxicokinetics, bioaccumulation, tissue distribution and enantiomeric profiles of sulfoxaflor in rats were investigated through single oral exposure and 28-days continuous exposure experiment. Sulfoxaflor mainly accumulated in liver and kidney, and the (-)-2R,3R-sufloxaflor and (-)-2S,3R-sufloxaflor had higher enrichment than their enantiomers in rats. The toxicological effects were evaluated after 28-days exposure. Slight inflammation in liver and kidney were observed by histopathology. Sphingolipid, amino acid, and vitamin B6 metabolism pathways were significantly disturbed in metabonomics analysis. These ...
Source: Chemosphere - April 18, 2024 Category: Chemistry Authors: Yaofeng Fang Shengchen Lv Shouchun Xiao Haonan Hou Jianing Yao Yue Cao Bingying He Xueke Liu Peng Wang Donghui Liu Zhiqiang Zhou Source Type: research
Substitution of bridge carbons for sulphur in calix[4]arene-bis- α-hydroxymethylphosphonic acid transformed mobile carrier into ionic channel accompanied with evoked muscle contraction and impaired neurotransmission powered by membrane action of resulting thiocalix[4]arene-bis-α-hydroxymethylphosphonic acid
Toxicol In Vitro. 2024 Apr 16:105815. doi: 10.1016/j.tiv.2024.105815. Online ahead of print.ABSTRACTThe action of calix[4]arenes C-424, C-425 and C-1193 has been investigated on suspended cholesterol/egg phosphatidylcholine lipid bilayer in a voltage-clamp mode. Comparative analysis with the membrane action by calix[4]arene-bis-α-hydroxymethylphosphonic acid (C-99) has shown that the substitution of bridge carbons for sulphur and addition of another methyl group to two alkyl tales in the lower rim of former dipropoxycalix[4]arene C-99 transformed mobile carrier that C-99 created in lipid bilayer (Shatursky et al., 2014) i...
Source: Toxicology in Vitro - April 18, 2024 Category: Toxicology Authors: Oleg Ya Shatursky Natalia V Krisanova Natalia Pozdnyakova Artem O Pastukhov Marina Dudarenko Lilia Kalynovska Alexander A Shkrabak Tatiana O Veklich Anna I Selikhova Serhii O Cherenok Tatiana A Borisova Vitaly I Kalchenko Sergyi O Kosterin Source Type: research
A progress update on the biological effects of biodegradable microplastics on soil and ocean environment: a perfect substitute or new threat?
Environ Res. 2024 Apr 16:118960. doi: 10.1016/j.envres.2024.118960. Online ahead of print.ABSTRACTConventional plastics are inherently difficult to degrade, causing serious plastic pollution. With the development of society, biodegradable plastics (BPs) are considered as an alternative to traditional plastics. However, current research indicated that BPs do not undergo complete degradation in natural environments. Instead, they may convert into biodegradable microplastics (BMPs) at an accelerated rate, thereby posing a significant threat to environment. In this paper, the definition, application, distribution, degradation ...
Source: Environmental Research - April 18, 2024 Category: Environmental Health Authors: Daqin Wang Fei Xiong Lingjie Wu Zhihui Liu Kai Xu Jiawei Huang Jinyan Liu Qin Ding Juan Zhang Yuepu Pu Rongli Sun Source Type: research
ACMT Comment on Recent Guidance on PFAS Laboratory Testing
J Med Toxicol. 2024 Apr 18. doi: 10.1007/s13181-024-01004-1. Online ahead of print.NO ABSTRACTPMID:38637420 | DOI:10.1007/s13181-024-01004-1 (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - April 18, 2024 Category: Toxicology Authors: John W Downs Nicholas E Nacca Andrew I Stolbach Michael G Holland Source Type: research
Biosimilars production in Africa opportunities & amp; challenges
Regul Toxicol Pharmacol. 2024 Apr 16;149:105626. doi: 10.1016/j.yrtph.2024.105626. Online ahead of print.ABSTRACTThe healthcare systems of African nations heavily rely on importing and repackaging biological medicine. More than 70% of the pharmaceutical products consumed in Africa are imported. The localization of biosimilar production can have a positive impact on the availability and cost of these products by reducing the expenses for African governments and making essential healthcare products more accessible to the population. However, it is evident that the developing countries, particularly African nations, face vari...
Source: Regulatory Toxicology and Pharmacology : RTP - April 18, 2024 Category: Toxicology Authors: Amany E Abdel-Maged Margrit F Mikhaeil Ahmed I Elkordy Amany M Gad Mohamed M Elshazly Source Type: research
Mimicking Ozonolysis via Mechanochemistry: Internal Alkynes to 1,2-Diketones using H5IO6
Chemistry. 2024 Apr 18:e202401027. doi: 10.1002/chem.202401027. Online ahead of print.ABSTRACTUtilizing periodic acid as an environmentally benign oxidizing agent, this study introduces a novel mechanochemical method that mimics ozonolysis to convert internal alkynes into 1,2-diketones, showcasing effective emulation of ozone's reactivity. Notably, this oxidation occurs at room temperature in aerobic conditions, eliminating the need for toxic transition metals, hazardous oxidants, or expensive solvents. Through control experiments validating the mechanism, substantial evidence supports a concerted reaction pathway. This pr...
Source: Chemistry - April 18, 2024 Category: Chemistry Authors: Pravat Nayek Prasenjit Mal Source Type: research
Identifying piRNAs that regulate BaP-induced lung injuries: A bottom-up approach from toxicity pathway investigation to animal validation
Ecotoxicol Environ Saf. 2024 Apr 17;277:116330. doi: 10.1016/j.ecoenv.2024.116330. Online ahead of print.ABSTRACTPIWI-interacting RNAs (piRNAs) is an emerging class of small non-coding RNAs that has been recently reported to have functions in infertility, tumorigenesis, and multiple diseases in humans. Previously, 5 toxicity pathways were proposed from hundreds of toxicological studies that underlie BaP-induced lung injuries, and a "Bottom-up" approach was established to identify small non-coding RNAs that drive BaP-induced pulmonary effects by investigating the activation of these pathways in vitro, and the expression of ...
Source: Ecotoxicology and Environmental Safety - April 18, 2024 Category: Environmental Health Authors: Qinkai Lei Chenlong Du Yumei Ma Yingqing Shou Li Chen Chiyuan Feng Yuxin Zheng Dianke Yu Yuan Jin Source Type: research
The use of amino acids and their derivates to mitigate against pesticide-induced toxicity
Ecotoxicol Environ Saf. 2024 Apr 17;276:116340. doi: 10.1016/j.ecoenv.2024.116340. Online ahead of print.ABSTRACTExposure to pesticides induces oxidative stress and deleterious effects on various tissues in non-target organisms. Numerous models investigating pesticide exposure have demonstrated metabolic disturbances such as imbalances in amino acid levels within the organism. One potentially effective strategy to mitigate pesticide toxicity involves dietary intervention by supplementing exogenous amino acids and their derivates to augment the body's antioxidant capacity and mitigate pesticide-induced oxidative harm, whose...
Source: Ecotoxicology and Environmental Safety - April 18, 2024 Category: Environmental Health Authors: Guo-Ping Zhao Wei-Long Cheng Zhi-Hui Zhang Yi-Xuan Li Ying-Qiu Li Fang-Wei Yang Yan-Bo Wang Source Type: research
miR-584-5p / Ykt6 - mediated autophagy - lysosome - exosome pathway as a critical route affecting the toxic effects of lead on HK-2 cells
This study aimed to investigate the role of miR-584-5p / Ykt6 axis in the toxic effect of lead on HK-2 cells and the related mechanism. Our data suggested that lead exposure caused significant cytotoxicity, DNA and chromosome damage to HK-2 cells. Mechanistically, lead exposure down-regulated miR-584-5p and up-regulated Ykt6 expression, consequently, autophagosomal number and autophagic flux increased, lysosomal number and activity decreased, exosomal secretion increased. Interestingly, when miR-584-5p level was enhanced with mimic, autophagosomal number and autophagic flux decreased, lysosomal number and activity increase...
Source: Ecotoxicology and Environmental Safety - April 18, 2024 Category: Environmental Health Authors: Yiren Xiong Zuqing Hu Di Ouyang Meilin Tang Jiayi He Shanshan He Renyi Liu Zhenjie Gao Ying Chen Dalin Hu Source Type: research
Nanotechnology and malaria: Evaluation of efficacy and toxicity of green nanoparticles
J Vector Borne Dis. 2024 Apr 12. doi: 10.4103/JVBD.JVBD_175_23. Online ahead of print.ABSTRACTMalaria is a global health problem that causes 1.5-2.7 million deaths worldwide each year. Resistance to antimalarial drugs in malaria parasites and to insecticides in vectors is one of the most serious issues in the fight against the disease. Moreover, the lack of an effective vaccine against malaria is still a major concern. Recent developments in nanotechnology have resulted in new prospects for the fight against malaria, especially by obtaining metal nanoparticles (NPs) that are less toxic, highly biocompatible, environmentall...
Source: Journal of Vector Borne Diseases - April 18, 2024 Category: Infectious Diseases Authors: Ana Barati Ayan Huseynzade Nergiz Imamova Inji Shikhaliyeva Sedanur Keles Jahid Alakbarli Bu şra Akgul Melahat Bagirova Adil M Allahverdiyev Source Type: research
