Adaptive radiotherapy for head and neck cancer: Pitfalls and possibilities from the radiation oncologist's point of view
ConclusionAlthough based on mainly non-randomized and retrospective trials, there is accumulating evidence that ART has the potential to reduce toxicity and improve quality of life and tumor control in HNC patients treated with RT. However, several questions remain regarding accurate patient selection, the ideal frequency and timing of replanning, and the appropriate way for image registration and dose calculation. Well-designed randomized prospective trials, with a predetermined protocol for both image registration and dose summation, are urgently needed to further investigate the dosimetric and clinical benefits of ART. ...
Source: Cancer Medicine - April 23, 2024 Category: Cancer & Oncology Authors: Sandra Nuyts,
Heleen Bollen,
Avrahram Eisbruch,
Primoz Strojan,
William M. Mendenhall,
Sweet Ping Ng,
Alfio Ferlito Tags: REVIEW Source Type: research
The multifaceted role of macrophage mitophagy in SiO2 ‐induced pulmonary fibrosis: A brief review
AbstractProlonged exposure to environments with high concentrations of crystalline silica (CS) can lead to silicosis. Macrophages play a crucial role in the pathogenesis of silicosis. In the process of silicosis, silica (SiO2) invades alveolar macrophages (AMs) and induces mitophagy which usually exists in three states: normal, excessive, and/or deficiency. Different mitophagy states lead to corresponding toxic responses, including successful macrophage repair, injury, necrosis, apoptosis, and even pulmonary fibrosis. This is a complex process accompanied by various cytokines. Unfortunately, the details have not been fully...
Source: Journal of Applied Toxicology - April 23, 2024 Category: Toxicology Authors: Yu ‐ting Zhou,
Shuang Li,
Shu‐ling Du,
Jia‐hui Zhao,
Ya‐qiong Cai,
Zhao‐qiang Zhang Tags: REVIEW ARTICLE Source Type: research
Amphipathic Emulsion Binder for Enhanced Performance of Lithium-Sulfur Batteries
J. Mater. Chem. A, 2024, Accepted Manuscript DOI: 10.1039/D4TA01037J, PaperYuan He, Xulong Jing, Tianxing Lai, Dong Jiang, Chao Wan, Pavel S Postnikov, Olga Guselnikova, Lixin Xu, Xiaojun He, Yusuke Yamauchi , Biyu Jin The application of polyvinylidene fluoride (PVDF) binder in lithium-sulfur batteries faces challenges due to inadequate adhesion, undesirable conductivities, limited lithium polysulfides absorbability, and its dependence on the use of toxic... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Mater. Chem. latest articles)
Source: RSC - J. Mater. Chem. latest articles - April 23, 2024 Category: Chemistry Authors: Yuan He Source Type: research
Triton B Catalyzed Rapid and Mild Synthetic Protocol for both Henry Reaction of Isatin and Michael Reaction of Chalcone with Nitroalkane
Synlett DOI: 10.1055/s-0043-1774862 A highly efficient and general synthetic protocol for both Henry and Michael reactions was developed using metal-free catalyst Triton B (benzyltrimethylammonium hydroxide) and isatins and chalcones, respectively. This methodology is inexpensive, the reagents are easy to handle, and the approach offers wide functional group tolerance of isatins and chalcones. The base catalyst Triton B is less toxic, recyclable, and reusable. This efficient method reduces reaction times, minimizes reagent excess, avoids chromatography, and is aligned with sustainable chemistry principles, offering eco-fri...
Source: Synlett - April 23, 2024 Category: Chemistry Authors: Talukdar, Mrinal Islam, Nasreen Mishra, Akanksha Dave, Alpa Y Begari, Eeshwaraiah Tags: letter Source Type: research
Anti-cancer potential of zerumbone in cancer and glioma: current trends and future perspectives
AbstractPlant-derived immunomodulators and antitumor factors have appealed lots of attention from natural product scientists for their efficiency and safety and their important contribution to well-designed targeted drug action and delivery mechanisms. Zerumbone (ZER), the chief component ofZingiber zerumbet rhizomes, has been examined for its wide-spectrum in the treatment of multi-targeted diseases. The rhizomes have been used as food flavoring agents in numerous cuisines and in flora medication. Numerous in vivo and in vitro experiments have prepared confirmation of ZER as a potent immunomodulator as well as a potential...
Source: Medical Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
Combining biomarkers of susceptibility with toxicodynamic models: a novel approach for assessing modifying factors
AbstractBiomarkers of susceptibility are indicative of an individual ’s capacity to react to particular exposures, whereas toxicodynamic models elucidate the correlation between exposure and response. In this article, a novel methodology is presented for the evaluation of modifying factors in the field of toxicology. The proposed approach involves the integration o f biomarkers of susceptibility with toxicodynamic models. Through the integration of these two methodologies, scientists are able to gain a more comprehensive understanding of the impact of modifying factors, such as genetic polymorphisms or epigenetic profile...
Source: Journal of Environmental Health Science and Engineering - April 23, 2024 Category: Environmental Health Source Type: research
Molecules, Vol. 29, Pages 1927: Unraveling the Nephroprotective Potential of Papaverine against Cisplatin Toxicity through Mitigating Oxidative Stress and Inflammation: Insights from In Silico, In Vitro, and In Vivo Investigations
This study investigated whether papaverine could mitigate cisplatin-induced kidney damage while preserving its chemotherapeutic efficacy. Integrative bioinformatics analysis predicted papaverine modulation of the mechanistic pathways related to cisplatin renal toxicity; notably, mitogen-activated protein kinase 1 (MAPK1) signaling. We validated protective effects in normal kidney cells without interfering with cisplatin cytotoxicity on a cancer cell line. Concurrent in vivo administration of papaverine alongside cisplatin in rats prevented elevations in nephrotoxicity markers, including serum creatinine, blood urea nitroge...
Source: Molecules - April 23, 2024 Category: Chemistry Authors: Shimaa A. Abass Abdullah A. Elgazar Sanad S. El-kholy Amal I. El-Refaiy Reem A. Nawaya Mashooq Ahmad Bhat Foad A. Farrag Abdelrahman Hamdi Marwa Balaha Mohammed A. El-Magd Tags: Article Source Type: research
Exploring the effect of BRCA1/2 status on chemotherapy-induced hematologic toxicity in patients with ovarian cancer
ConclusionGermlineBRCA mutations were associated with a higher frequency of G2/3 anemia in ovarian cancer patients who underwent first-line platinum-based chemotherapy. Moreover, theBRCA1 mutation appeared to be more strongly associated with the incidence of chemotherapy-induced anemia. Our findings warrant further investigation in larger, prospective studies to confirm these current findings and determine whether preventive interventions may be necessary. (Source: Cancer Chemotherapy and Pharmacology)
Source: Cancer Chemotherapy and Pharmacology - April 23, 2024 Category: Cancer & Oncology Source Type: research
Navigating Breast Cancer Oligometastasis and Oligoprogression: Current Landscape and Future Directions
ConclusionWhile there is interest in applying local therapies to OM and OP breast cancer, the current randomized data does not back the routine use of surgery or SBRT, particularly when considering the potential for treatment-related toxicities. Future research should refine patient selection through advanced imaging and possibly explore these therapies specifically in patients with hormone receptor-positive or HER2-positive disease. (Source: Current Oncology Reports)
Source: Current Oncology Reports - April 23, 2024 Category: Cancer & Oncology Source Type: research
Neem leaf glycoprotein binding to Dectin-1 receptors on dendritic cell induces type-1 immunity through CARD9 mediated intracellular signal to NF κB
A water-soluble ingredient of mature leaves of the tropical mahogany ‘Neem’ (Azadirachta indica), was identified as glycoprotein, thus being named as ‘Neem Leaf Glycoprotein’ (NLGP). This non-toxic leaf-component... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 23, 2024 Category: Molecular Biology Authors: Nilanjan Ganguly, Tapasi Das, Avishek Bhuniya, Ipsita Guha, Mohona Chakravarti, Sukanya Dhar, Anirban Sarkar, Saurav Bera, Jesmita Dhar, Shayani Dasgupta, Akata Saha, Tithi Ghosh, Juhina Das, Ugir Hossain Sk, Saptak Banerjee, Subrata Laskar & hellip; Tags: Research Source Type: research
Allergen-specific immunotherapy for mold allergies
AbstractMolds are ubiquitous in our environment and are considered by the population to be the most important indoor pollutant problem [1]. The current 2023 update to the AWMF mold guideline [1] is intended to allay or channel fears and provide assistance for a sensible diagnosis and treatment decision.The detection of an IgE-mediated allergy implies for allergists Allergen immunotherapy (AIT) as an established treatment option. However, compared to the well-validated AIT with pollen and house dust mites, the decision to use AIT with mold extracts must be weighed more heavily between the benefits and risks.Spores ofAlter...
Source: Allergo Journal International - April 23, 2024 Category: Allergy & Immunology Source Type: research
N-methyl-D-aspartate receptors and thymoquinone induce apoptosis and alteration in mitochondria in colorectal cancer cells
This study aimed to determine the roles of N-Methyl-D-Aspartate agonists and Thymoquinone on mitochondria and apoptosis. HT-29 cells were treated with different TQ and MK-801 concentrations. We analyzed cell viability, apoptosis, and alteration of mitochondria. Cell viability significantly decreased depending on doses of TQ and MK-801. Apoptosis and mitochondrial dysfunctions induced by low and high doses of TQ and MK-801. Our study emphasizes the need for further safety evaluation of MK-801 due to the potential toxicity risk of TQ and MK-801. Optimal and toxic doses of TQ and MK-801 were determined for the treatment of co...
Source: Medical Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
Haptoglobin Attenuates Cerebrospinal Fluid Hemoglobin-Induced Neurological Deterioration in Sheep
Abstract Secondary brain injury (SBI) occurs with a lag of several days post-bleeding in patients with aneurysmal subarachnoid hemorrhage (aSAH) and is a strong contributor to mortality and long-term morbidity. aSAH-SBI coincides with cell-free hemoglobin (Hb) release into the cerebrospinal fluid. This temporal association and convincing pathophysiological concepts suggest that CSF-Hb could be a targetable trigger of SBI. However, sparse experimental evidence for Hb ’s neurotoxicity in vivo defines a significant research gap for clinical translation. We modeled the CSF-Hb exposure observed in aSAH patients in conscious s...
Source: Translational Stroke Research - April 23, 2024 Category: Neurology Source Type: research
Predicting drug –drug interactions in breast cancer patients treated with CDK4/6 inhibitors and forward planning
. (Source: Expert Opinion on Drug Metabolism and Toxicology)
Source: Expert Opinion on Drug Metabolism and Toxicology - April 23, 2024 Category: Drugs & Pharmacology Authors: Abha KulkarniJasmeet Singha Department of Medicine, New York Presbyterian Weill Cornell, New York, NY USAb Department of Breast Medicine, Memorial Sloan Kettering Cancer Center, West Harrison, NY USA Source Type: research
Cancers, Vol. 16, Pages 1614: Pharmacodynamic and Toxicity Studies of 6-Isopropyldithio-2 & prime;-Guanosine Analogs in Acute T-Lymphoblastic Leukemia
Conclusions: YLS010 has demonstrated specific killing effects against acute T-lymphoblastic leukemia both in vivo and in vitro. Preclinical studies of YLS010 offer a new opportunity for the treatment of patients with acute T-lymphoblastic leukemia in clinical settings. (Source: Cancers)
Source: Cancers - April 23, 2024 Category: Cancer & Oncology Authors: Tiantian Song Zheming Yu Qitao Shen Yu Xu Haihong Hu Junqing Liu Kui Zeng Jinxiu Lei Lushan Yu Tags: Article Source Type: research
